HEADER TRANSLATION 20-JUN-17 5OA3
TITLE HUMAN 40S-EIF2D-RE-INITIATION COMPLEX
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: EUKARYOTIC TRANSLATION INITIATION FACTOR 2D;
COMPND 3 CHAIN: 0;
COMPND 4 SYNONYM: EIF2D,HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 56,
COMPND 5 LIGATIN;
COMPND 6 ENGINEERED: YES;
COMPND 7 MOL_ID: 2;
COMPND 8 MOLECULE: INITIATOR MET-TRNA-I;
COMPND 9 CHAIN: 1;
COMPND 10 MOL_ID: 3;
COMPND 11 MOLECULE: 18S RIBOSOMAL RNA;
COMPND 12 CHAIN: 2;
COMPND 13 MOL_ID: 4;
COMPND 14 MOLECULE: IRES MRNA;
COMPND 15 CHAIN: 3;
COMPND 16 FRAGMENT: (DELTA DOMAIN II MUTANT, IN WHICH DOMAIN II OF THE IRES IS
COMPND 17 REPLACED WITH A SMALL STEM LOOP;
COMPND 18 ENGINEERED: YES;
COMPND 19 OTHER_DETAILS: HCV IRES MRNA (DELTA DOMAIN II MUTANT, IN WHICH DOMAIN
COMPND 20 II OF THE IRES IS REPLACED WITH A SMALL STEM LOOP);
COMPND 21 MOL_ID: 5;
COMPND 22 MOLECULE: 40S RIBOSOMAL PROTEIN SA;
COMPND 23 CHAIN: A;
COMPND 24 SYNONYM: 37 KDA LAMININ RECEPTOR PRECURSOR,37LRP,37/67 KDA LAMININ
COMPND 25 RECEPTOR,LRP/LR,67 KDA LAMININ RECEPTOR,67LR,COLON CARCINOMA LAMININ-
COMPND 26 BINDING PROTEIN,LAMININ RECEPTOR 1,LAMR,LAMININ-BINDING PROTEIN
COMPND 27 PRECURSOR P40,LBP/P40,MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN MGR1-
COMPND 28 AG,NEM/1CHD4,SMALL RIBOSOMAL SUBUNIT PROTEIN US2;
COMPND 29 MOL_ID: 6;
COMPND 30 MOLECULE: 40S RIBOSOMAL PROTEIN S3A;
COMPND 31 CHAIN: B;
COMPND 32 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES1,V-FOS TRANSFORMATION
COMPND 33 EFFECTOR PROTEIN,FTE-1;
COMPND 34 MOL_ID: 7;
COMPND 35 MOLECULE: 40S RIBOSOMAL PROTEIN S2;
COMPND 36 CHAIN: C;
COMPND 37 SYNONYM: 40S RIBOSOMAL PROTEIN S4,PROTEIN LLREP3,SMALL RIBOSOMAL
COMPND 38 SUBUNIT PROTEIN US5;
COMPND 39 MOL_ID: 8;
COMPND 40 MOLECULE: 40S RIBOSOMAL PROTEIN S3;
COMPND 41 CHAIN: D;
COMPND 42 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US3;
COMPND 43 EC: 4.2.99.18;
COMPND 44 MOL_ID: 9;
COMPND 45 MOLECULE: 40S RIBOSOMAL PROTEIN S4, X ISOFORM;
COMPND 46 CHAIN: E;
COMPND 47 SYNONYM: SCR10,SINGLE COPY ABUNDANT MRNA PROTEIN,SMALL RIBOSOMAL
COMPND 48 SUBUNIT PROTEIN ES4;
COMPND 49 MOL_ID: 10;
COMPND 50 MOLECULE: 40S RIBOSOMAL PROTEIN S5;
COMPND 51 CHAIN: F;
COMPND 52 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US7;
COMPND 53 MOL_ID: 11;
COMPND 54 MOLECULE: 40S RIBOSOMAL PROTEIN S6;
COMPND 55 CHAIN: G;
COMPND 56 SYNONYM: PHOSPHOPROTEIN NP33,SMALL RIBOSOMAL SUBUNIT PROTEIN ES6;
COMPND 57 MOL_ID: 12;
COMPND 58 MOLECULE: 40S RIBOSOMAL PROTEIN S7;
COMPND 59 CHAIN: H;
COMPND 60 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES7;
COMPND 61 MOL_ID: 13;
COMPND 62 MOLECULE: 40S RIBOSOMAL PROTEIN S8;
COMPND 63 CHAIN: I;
COMPND 64 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES8;
COMPND 65 MOL_ID: 14;
COMPND 66 MOLECULE: 40S RIBOSOMAL PROTEIN S9;
COMPND 67 CHAIN: J;
COMPND 68 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US4;
COMPND 69 MOL_ID: 15;
COMPND 70 MOLECULE: 40S RIBOSOMAL PROTEIN S10;
COMPND 71 CHAIN: K;
COMPND 72 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES10;
COMPND 73 MOL_ID: 16;
COMPND 74 MOLECULE: 40S RIBOSOMAL PROTEIN S11;
COMPND 75 CHAIN: L;
COMPND 76 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US17;
COMPND 77 MOL_ID: 17;
COMPND 78 MOLECULE: 40S RIBOSOMAL PROTEIN S12;
COMPND 79 CHAIN: M;
COMPND 80 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES12;
COMPND 81 MOL_ID: 18;
COMPND 82 MOLECULE: 40S RIBOSOMAL PROTEIN S13;
COMPND 83 CHAIN: N;
COMPND 84 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US15;
COMPND 85 MOL_ID: 19;
COMPND 86 MOLECULE: 40S RIBOSOMAL PROTEIN S14;
COMPND 87 CHAIN: O;
COMPND 88 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US11;
COMPND 89 MOL_ID: 20;
COMPND 90 MOLECULE: 40S RIBOSOMAL PROTEIN S15;
COMPND 91 CHAIN: P;
COMPND 92 SYNONYM: RIG PROTEIN,SMALL RIBOSOMAL SUBUNIT PROTEIN US19;
COMPND 93 MOL_ID: 21;
COMPND 94 MOLECULE: 40S RIBOSOMAL PROTEIN S16;
COMPND 95 CHAIN: Q;
COMPND 96 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US9;
COMPND 97 MOL_ID: 22;
COMPND 98 MOLECULE: 40S RIBOSOMAL PROTEIN S17;
COMPND 99 CHAIN: R;
COMPND 100 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES17;
COMPND 101 MOL_ID: 23;
COMPND 102 MOLECULE: 40S RIBOSOMAL PROTEIN S18;
COMPND 103 CHAIN: S;
COMPND 104 SYNONYM: KE-3,KE3,SMALL RIBOSOMAL SUBUNIT PROTEIN US13;
COMPND 105 MOL_ID: 24;
COMPND 106 MOLECULE: 40S RIBOSOMAL PROTEIN S19;
COMPND 107 CHAIN: T;
COMPND 108 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES19;
COMPND 109 MOL_ID: 25;
COMPND 110 MOLECULE: 40S RIBOSOMAL PROTEIN S20;
COMPND 111 CHAIN: U;
COMPND 112 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US10;
COMPND 113 MOL_ID: 26;
COMPND 114 MOLECULE: 40S RIBOSOMAL PROTEIN S21;
COMPND 115 CHAIN: V;
COMPND 116 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES21;
COMPND 117 MOL_ID: 27;
COMPND 118 MOLECULE: 40S RIBOSOMAL PROTEIN S15A;
COMPND 119 CHAIN: W;
COMPND 120 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US8;
COMPND 121 MOL_ID: 28;
COMPND 122 MOLECULE: 40S RIBOSOMAL PROTEIN S23;
COMPND 123 CHAIN: X;
COMPND 124 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US12;
COMPND 125 MOL_ID: 29;
COMPND 126 MOLECULE: 40S RIBOSOMAL PROTEIN S24;
COMPND 127 CHAIN: Y;
COMPND 128 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES24;
COMPND 129 MOL_ID: 30;
COMPND 130 MOLECULE: 40S RIBOSOMAL PROTEIN S25;
COMPND 131 CHAIN: Z;
COMPND 132 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES25;
COMPND 133 MOL_ID: 31;
COMPND 134 MOLECULE: 40S RIBOSOMAL PROTEIN S26;
COMPND 135 CHAIN: a;
COMPND 136 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES26;
COMPND 137 MOL_ID: 32;
COMPND 138 MOLECULE: 40S RIBOSOMAL PROTEIN S27;
COMPND 139 CHAIN: b;
COMPND 140 SYNONYM: METALLOPAN-STIMULIN 1,MPS-1,SMALL RIBOSOMAL SUBUNIT PROTEIN
COMPND 141 ES27;
COMPND 142 MOL_ID: 33;
COMPND 143 MOLECULE: 40S RIBOSOMAL PROTEIN S28;
COMPND 144 CHAIN: c;
COMPND 145 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES28;
COMPND 146 MOL_ID: 34;
COMPND 147 MOLECULE: 40S RIBOSOMAL PROTEIN S29;
COMPND 148 CHAIN: d;
COMPND 149 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US14;
COMPND 150 MOL_ID: 35;
COMPND 151 MOLECULE: 40S RIBOSOMAL PROTEIN S30;
COMPND 152 CHAIN: e;
COMPND 153 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES30;
COMPND 154 MOL_ID: 36;
COMPND 155 MOLECULE: RIBOSOMAL PROTEIN S27A;
COMPND 156 CHAIN: f;
COMPND 157 MOL_ID: 37;
COMPND 158 MOLECULE: RECEPTOR OF ACTIVATED PROTEIN C KINASE 1;
COMPND 159 CHAIN: g;
COMPND 160 SYNONYM: CELL PROLIFERATION-INDUCING GENE 21 PROTEIN,GUANINE
COMPND 161 NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2-LIKE 1,GUANINE NUCLEOTIDE-
COMPND 162 BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 12.3,HUMAN LUNG CANCER
COMPND 163 ONCOGENE 7 PROTEIN,HLC-7,RECEPTOR FOR ACTIVATED C KINASE,SMALL
COMPND 164 RIBOSOMAL SUBUNIT PROTEIN RACK1;
COMPND 165 MOL_ID: 38;
COMPND 166 MOLECULE: RIBOSOMAL PROTEIN EL41;
COMPND 167 CHAIN: h
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 3 ORGANISM_COMMON: HUMAN;
SOURCE 4 ORGANISM_TAXID: 9606;
SOURCE 5 GENE: EIF2D, HCA56, LGTN;
SOURCE 6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 7 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 8 MOL_ID: 2;
SOURCE 9 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;
SOURCE 10 ORGANISM_TAXID: 4932;
SOURCE 11 MOL_ID: 3;
SOURCE 12 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 13 ORGANISM_COMMON: HUMAN;
SOURCE 14 ORGANISM_TAXID: 9606;
SOURCE 15 MOL_ID: 4;
SOURCE 16 SYNTHETIC: YES;
SOURCE 17 ORGANISM_SCIENTIFIC: HEPATITIS C VIRUS;
SOURCE 18 ORGANISM_TAXID: 11103;
SOURCE 19 MOL_ID: 5;
SOURCE 20 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 21 ORGANISM_COMMON: HUMAN;
SOURCE 22 ORGANISM_TAXID: 9606;
SOURCE 23 MOL_ID: 6;
SOURCE 24 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 25 ORGANISM_COMMON: HUMAN;
SOURCE 26 ORGANISM_TAXID: 9606;
SOURCE 27 MOL_ID: 7;
SOURCE 28 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 29 ORGANISM_COMMON: HUMAN;
SOURCE 30 ORGANISM_TAXID: 9606;
SOURCE 31 MOL_ID: 8;
SOURCE 32 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 33 ORGANISM_COMMON: HUMAN;
SOURCE 34 ORGANISM_TAXID: 9606;
SOURCE 35 MOL_ID: 9;
SOURCE 36 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 37 ORGANISM_COMMON: HUMAN;
SOURCE 38 ORGANISM_TAXID: 9606;
SOURCE 39 MOL_ID: 10;
SOURCE 40 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 41 ORGANISM_COMMON: HUMAN;
SOURCE 42 ORGANISM_TAXID: 9606;
SOURCE 43 MOL_ID: 11;
SOURCE 44 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 45 ORGANISM_COMMON: HUMAN;
SOURCE 46 ORGANISM_TAXID: 9606;
SOURCE 47 MOL_ID: 12;
SOURCE 48 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 49 ORGANISM_COMMON: HUMAN;
SOURCE 50 ORGANISM_TAXID: 9606;
SOURCE 51 MOL_ID: 13;
SOURCE 52 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 53 ORGANISM_COMMON: HUMAN;
SOURCE 54 ORGANISM_TAXID: 9606;
SOURCE 55 MOL_ID: 14;
SOURCE 56 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 57 ORGANISM_COMMON: HUMAN;
SOURCE 58 ORGANISM_TAXID: 9606;
SOURCE 59 MOL_ID: 15;
SOURCE 60 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 61 ORGANISM_COMMON: HUMAN;
SOURCE 62 ORGANISM_TAXID: 9606;
SOURCE 63 MOL_ID: 16;
SOURCE 64 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 65 ORGANISM_COMMON: HUMAN;
SOURCE 66 ORGANISM_TAXID: 9606;
SOURCE 67 MOL_ID: 17;
SOURCE 68 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 69 ORGANISM_COMMON: HUMAN;
SOURCE 70 ORGANISM_TAXID: 9606;
SOURCE 71 MOL_ID: 18;
SOURCE 72 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 73 ORGANISM_COMMON: HUMAN;
SOURCE 74 ORGANISM_TAXID: 9606;
SOURCE 75 MOL_ID: 19;
SOURCE 76 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 77 ORGANISM_COMMON: HUMAN;
SOURCE 78 ORGANISM_TAXID: 9606;
SOURCE 79 MOL_ID: 20;
SOURCE 80 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 81 ORGANISM_COMMON: HUMAN;
SOURCE 82 ORGANISM_TAXID: 9606;
SOURCE 83 MOL_ID: 21;
SOURCE 84 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 85 ORGANISM_COMMON: HUMAN;
SOURCE 86 ORGANISM_TAXID: 9606;
SOURCE 87 MOL_ID: 22;
SOURCE 88 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 89 ORGANISM_COMMON: HUMAN;
SOURCE 90 ORGANISM_TAXID: 9606;
SOURCE 91 MOL_ID: 23;
SOURCE 92 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 93 ORGANISM_COMMON: HUMAN;
SOURCE 94 ORGANISM_TAXID: 9606;
SOURCE 95 MOL_ID: 24;
SOURCE 96 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 97 ORGANISM_COMMON: HUMAN;
SOURCE 98 ORGANISM_TAXID: 9606;
SOURCE 99 MOL_ID: 25;
SOURCE 100 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 101 ORGANISM_COMMON: HUMAN;
SOURCE 102 ORGANISM_TAXID: 9606;
SOURCE 103 MOL_ID: 26;
SOURCE 104 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 105 ORGANISM_COMMON: HUMAN;
SOURCE 106 ORGANISM_TAXID: 9606;
SOURCE 107 MOL_ID: 27;
SOURCE 108 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 109 ORGANISM_COMMON: HUMAN;
SOURCE 110 ORGANISM_TAXID: 9606;
SOURCE 111 MOL_ID: 28;
SOURCE 112 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 113 ORGANISM_COMMON: HUMAN;
SOURCE 114 ORGANISM_TAXID: 9606;
SOURCE 115 MOL_ID: 29;
SOURCE 116 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 117 ORGANISM_COMMON: HUMAN;
SOURCE 118 ORGANISM_TAXID: 9606;
SOURCE 119 MOL_ID: 30;
SOURCE 120 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 121 ORGANISM_COMMON: HUMAN;
SOURCE 122 ORGANISM_TAXID: 9606;
SOURCE 123 MOL_ID: 31;
SOURCE 124 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 125 ORGANISM_COMMON: HUMAN;
SOURCE 126 ORGANISM_TAXID: 9606;
SOURCE 127 MOL_ID: 32;
SOURCE 128 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 129 ORGANISM_COMMON: HUMAN;
SOURCE 130 ORGANISM_TAXID: 9606;
SOURCE 131 MOL_ID: 33;
SOURCE 132 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 133 ORGANISM_COMMON: HUMAN;
SOURCE 134 ORGANISM_TAXID: 9606;
SOURCE 135 MOL_ID: 34;
SOURCE 136 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 137 ORGANISM_COMMON: HUMAN;
SOURCE 138 ORGANISM_TAXID: 9606;
SOURCE 139 MOL_ID: 35;
SOURCE 140 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 141 ORGANISM_COMMON: HUMAN;
SOURCE 142 ORGANISM_TAXID: 9606;
SOURCE 143 MOL_ID: 36;
SOURCE 144 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 145 ORGANISM_COMMON: HUMAN;
SOURCE 146 ORGANISM_TAXID: 9606;
SOURCE 147 MOL_ID: 37;
SOURCE 148 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 149 ORGANISM_COMMON: HUMAN;
SOURCE 150 ORGANISM_TAXID: 9606;
SOURCE 151 MOL_ID: 38;
SOURCE 152 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 153 ORGANISM_COMMON: HUMAN;
SOURCE 154 ORGANISM_TAXID: 9606
KEYWDS TRANSLATION RE-INITIATION COMPLEX, SMALL RIBOSOMAL SUBUNIT, RNA
KEYWDS 2 BINDING PROTEIN, EUKARYOTIC TRANSLATION INITIATION FACTOR,
KEYWDS 3 TRANSLATION
EXPDTA ELECTRON MICROSCOPY
AUTHOR M.WEISSER,T.SCHAEFER,M.LEIBUNDGUT,D.BOEHRINGER,C.H.S.AYLETT,N.BAN
REVDAT 4 11-DEC-19 5OA3 1 CRYST1 SCALE
REVDAT 3 17-OCT-18 5OA3 1 REMARK
REVDAT 2 16-AUG-17 5OA3 1 JRNL
REVDAT 1 09-AUG-17 5OA3 0
JRNL AUTH M.WEISSER,T.SCHAFER,M.LEIBUNDGUT,D.BOHRINGER,C.H.S.AYLETT,
JRNL AUTH 2 N.BAN
JRNL TITL STRUCTURAL AND FUNCTIONAL INSIGHTS INTO HUMAN RE-INITIATION
JRNL TITL 2 COMPLEXES.
JRNL REF MOL. CELL V. 67 447 2017
JRNL REFN ISSN 1097-4164
JRNL PMID 28732596
JRNL DOI 10.1016/J.MOLCEL.2017.06.032
REMARK 2
REMARK 2 RESOLUTION. 4.30 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : EMAN, RELION, RELION, RELION, RELION,
REMARK 3 RELION
REMARK 3 RECONSTRUCTION SCHEMA : NULL
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : NULL
REMARK 3 REFINEMENT SPACE : NULL
REMARK 3 REFINEMENT PROTOCOL : NULL
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL
REMARK 3
REMARK 3 FITTING PROCEDURE : NULL
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 4.200
REMARK 3 NUMBER OF PARTICLES : 62177
REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE
REMARK 3 CORRECTION
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: NULL
REMARK 4
REMARK 4 5OA3 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 21-JUN-17.
REMARK 100 THE DEPOSITION ID IS D_1200005434.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : HUMAN TRANSLATION RE-INITIATION
REMARK 245 COMPLEX OF EIFD, INITIATOR TRNA
REMARK 245 AND THE SMALL RIBOSOMAL SUBUNIT;
REMARK 245 EIF2D; SMALL RIBOSOMAL SUBUNIT;
REMARK 245 HCV IRES MRNA; INITIATOR MET-
REMARK 245 TRNA-I
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.11
REMARK 245 SAMPLE SUPPORT DETAILS : NULL
REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 7.60
REMARK 245 SAMPLE DETAILS : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : NULL
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS
REMARK 245 DETECTOR TYPE : FEI FALCON II (4K X 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : NULL
REMARK 245 MAXIMUM DEFOCUS (NM) : NULL
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : NULL
REMARK 245 IMAGING MODE : BRIGHT FIELD
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 40.00
REMARK 245 ILLUMINATION MODE : FLOOD BEAM
REMARK 245 NOMINAL MAGNIFICATION : NULL
REMARK 245 CALIBRATED MAGNIFICATION : NULL
REMARK 245 SOURCE : FIELD EMISSION GUN
REMARK 245 ACCELERATION VOLTAGE (KV) : 300
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 38-MERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 201360 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 464010 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -1501.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: 0, 1, 2, 3, A, B, C, D, E, F,
REMARK 350 AND CHAINS: G, H, I, J, K, L, M, N, O,
REMARK 350 AND CHAINS: P, Q, R, S, T, U, V, W, X, Y,
REMARK 350 AND CHAINS: Z, a, b, c, d, e, f, g, h
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 SER 0 184
REMARK 465 PRO 0 185
REMARK 465 PRO 0 186
REMARK 465 SER 0 187
REMARK 465 ILE 0 188
REMARK 465 ALA 0 189
REMARK 465 PRO 0 190
REMARK 465 LEU 0 191
REMARK 465 ALA 0 192
REMARK 465 LEU 0 193
REMARK 465 ASP 0 194
REMARK 465 SER 0 195
REMARK 465 ALA 0 196
REMARK 465 ASP 0 197
REMARK 465 LEU 0 198
REMARK 465 SER 0 199
REMARK 465 GLU 0 200
REMARK 465 GLU 0 201
REMARK 465 LYS 0 202
REMARK 465 GLY 0 203
REMARK 465 SER 0 204
REMARK 465 VAL 0 205
REMARK 465 GLN 0 206
REMARK 465 MET 0 207
REMARK 465 ASP 0 208
REMARK 465 SER 0 209
REMARK 465 THR 0 210
REMARK 465 LEU 0 211
REMARK 465 GLN 0 212
REMARK 465 GLY 0 213
REMARK 465 ASP 0 214
REMARK 465 MET 0 215
REMARK 465 ARG 0 216
REMARK 465 HIS 0 217
REMARK 465 MET 0 218
REMARK 465 THR 0 219
REMARK 465 LEU 0 220
REMARK 465 GLU 0 221
REMARK 465 GLY 0 222
REMARK 465 GLU 0 223
REMARK 465 GLU 0 224
REMARK 465 GLU 0 225
REMARK 465 ASN 0 226
REMARK 465 GLY 0 227
REMARK 465 GLU 0 228
REMARK 465 VAL 0 229
REMARK 465 HIS 0 230
REMARK 465 GLN 0 231
REMARK 465 ALA 0 232
REMARK 465 ARG 0 233
REMARK 465 GLU 0 234
REMARK 465 ASP 0 235
REMARK 465 LYS 0 236
REMARK 465 SER 0 237
REMARK 465 LEU 0 238
REMARK 465 SER 0 239
REMARK 465 GLU 0 240
REMARK 465 ALA 0 241
REMARK 465 PRO 0 242
REMARK 465 GLU 0 243
REMARK 465 ASP 0 244
REMARK 465 THR 0 245
REMARK 465 SER 0 246
REMARK 465 THR 0 247
REMARK 465 ARG 0 248
REMARK 465 GLY 0 249
REMARK 465 LEU 0 250
REMARK 465 ASN 0 251
REMARK 465 GLN 0 252
REMARK 465 ASP 0 253
REMARK 465 SER 0 254
REMARK 465 THR 0 255
REMARK 465 ASP 0 256
REMARK 465 SER 0 257
REMARK 465 LYS 0 258
REMARK 465 THR 0 259
REMARK 465 LYS 0 348
REMARK 465 HIS 0 349
REMARK 465 PRO 0 350
REMARK 465 ARG 0 351
REMARK 465 ILE 0 352
REMARK 465 THR 0 353
REMARK 465 SER 0 354
REMARK 465 PHE 0 355
REMARK 465 VAL 0 356
REMARK 465 ILE 0 357
REMARK 465 PRO 0 358
REMARK 465 GLU 0 359
REMARK 465 PRO 0 360
REMARK 465 SER 0 361
REMARK 465 PRO 0 362
REMARK 465 THR 0 363
REMARK 465 SER 0 364
REMARK 465 GLN 0 365
REMARK 465 THR 0 366
REMARK 465 ILE 0 367
REMARK 465 GLN 0 368
REMARK 465 GLU 0 369
REMARK 465 GLY 0 370
REMARK 465 SER 0 371
REMARK 465 ARG 0 372
REMARK 465 GLU 0 373
REMARK 465 LYS 0 582
REMARK 465 LYS 0 583
REMARK 465 LYS 0 584
REMARK 465 C 2 131
REMARK 465 U 2 132
REMARK 465 C 2 133
REMARK 465 C 2 134
REMARK 465 U 2 135
REMARK 465 C 2 136
REMARK 465 U 2 137
REMARK 465 C 2 138
REMARK 465 C 2 139
REMARK 465 A 2 226
REMARK 465 U 2 227
REMARK 465 C 2 228
REMARK 465 A 2 229
REMARK 465 A 2 230
REMARK 465 A 2 231
REMARK 465 A 2 232
REMARK 465 C 2 233
REMARK 465 C 2 234
REMARK 465 A 2 235
REMARK 465 A 2 236
REMARK 465 C 2 237
REMARK 465 C 2 238
REMARK 465 C 2 239
REMARK 465 G 2 240
REMARK 465 G 2 241
REMARK 465 U 2 242
REMARK 465 C 2 243
REMARK 465 A 2 244
REMARK 465 G 2 245
REMARK 465 C 2 246
REMARK 465 C 2 247
REMARK 465 C 2 248
REMARK 465 C 2 249
REMARK 465 U 2 250
REMARK 465 C 2 251
REMARK 465 U 2 252
REMARK 465 C 2 253
REMARK 465 C 2 254
REMARK 465 G 2 255
REMARK 465 G 2 256
REMARK 465 C 2 257
REMARK 465 C 2 258
REMARK 465 C 2 259
REMARK 465 C 2 260
REMARK 465 G 2 261
REMARK 465 G 2 262
REMARK 465 C 2 263
REMARK 465 C 2 264
REMARK 465 G 2 265
REMARK 465 G 2 266
REMARK 465 G 2 267
REMARK 465 G 2 268
REMARK 465 G 2 269
REMARK 465 G 2 270
REMARK 465 C 2 271
REMARK 465 G 2 272
REMARK 465 G 2 273
REMARK 465 G 2 274
REMARK 465 C 2 275
REMARK 465 C 2 276
REMARK 465 G 2 277
REMARK 465 C 2 278
REMARK 465 G 2 279
REMARK 465 G 2 280
REMARK 465 C 2 281
REMARK 465 G 2 282
REMARK 465 G 2 283
REMARK 465 C 2 284
REMARK 465 U 2 285
REMARK 465 U 2 286
REMARK 465 C 2 323
REMARK 465 C 2 324
REMARK 465 C 2 325
REMARK 465 C 2 326
REMARK 465 G 2 327
REMARK 465 U 2 328
REMARK 465 U 2 689
REMARK 465 G 2 690
REMARK 465 G 2 691
REMARK 465 G 2 692
REMARK 465 A 2 693
REMARK 465 G 2 694
REMARK 465 C 2 695
REMARK 465 G 2 696
REMARK 465 G 2 697
REMARK 465 G 2 698
REMARK 465 C 2 699
REMARK 465 G 2 700
REMARK 465 G 2 701
REMARK 465 G 2 702
REMARK 465 C 2 703
REMARK 465 G 2 704
REMARK 465 G 2 705
REMARK 465 U 2 706
REMARK 465 C 2 707
REMARK 465 C 2 708
REMARK 465 G 2 709
REMARK 465 C 2 710
REMARK 465 C 2 711
REMARK 465 G 2 712
REMARK 465 C 2 713
REMARK 465 G 2 714
REMARK 465 A 2 715
REMARK 465 G 2 716
REMARK 465 G 2 717
REMARK 465 C 2 718
REMARK 465 G 2 719
REMARK 465 A 2 720
REMARK 465 G 2 721
REMARK 465 C 2 722
REMARK 465 C 2 723
REMARK 465 A 2 724
REMARK 465 C 2 725
REMARK 465 C 2 726
REMARK 465 G 2 727
REMARK 465 C 2 728
REMARK 465 C 2 729
REMARK 465 C 2 730
REMARK 465 G 2 731
REMARK 465 U 2 732
REMARK 465 C 2 733
REMARK 465 C 2 734
REMARK 465 C 2 735
REMARK 465 C 2 736
REMARK 465 G 2 737
REMARK 465 C 2 738
REMARK 465 C 2 739
REMARK 465 C 2 740
REMARK 465 C 2 741
REMARK 465 U 2 742
REMARK 465 U 2 743
REMARK 465 G 2 744
REMARK 465 C 2 745
REMARK 465 C 2 753
REMARK 465 G 2 754
REMARK 465 C 2 755
REMARK 465 C 2 756
REMARK 465 C 2 757
REMARK 465 C 2 758
REMARK 465 C 2 759
REMARK 465 U 2 760
REMARK 465 C 2 761
REMARK 465 G 2 762
REMARK 465 A 2 763
REMARK 465 U 2 764
REMARK 465 G 2 765
REMARK 465 C 2 766
REMARK 465 U 2 767
REMARK 465 C 2 768
REMARK 465 U 2 769
REMARK 465 U 2 770
REMARK 465 A 2 771
REMARK 465 G 2 772
REMARK 465 C 2 773
REMARK 465 U 2 774
REMARK 465 G 2 775
REMARK 465 A 2 776
REMARK 465 G 2 777
REMARK 465 U 2 778
REMARK 465 G 2 779
REMARK 465 U 2 780
REMARK 465 C 2 781
REMARK 465 C 2 782
REMARK 465 C 2 783
REMARK 465 G 2 784
REMARK 465 C 2 785
REMARK 465 G 2 786
REMARK 465 G 2 787
REMARK 465 G 2 788
REMARK 465 G 2 789
REMARK 465 C 2 790
REMARK 465 C 2 835
REMARK 465 G 2 836
REMARK 465 A 2 837
REMARK 465 G 2 838
REMARK 465 C 2 839
REMARK 465 C 2 840
REMARK 465 C 2 1417
REMARK 465 C 2 1418
REMARK 465 C 2 1419
REMARK 465 G 2 1420
REMARK 465 A 2 1421
REMARK 465 G 2 1422
REMARK 465 C 2 1423
REMARK 465 C 2 1433
REMARK 465 C 2 1434
REMARK 465 C 2 1435
REMARK 465 C 2 1436
REMARK 465 C 2 1437
REMARK 465 G 2 1552
REMARK 465 C 2 1553
REMARK 465 C 2 1554
REMARK 465 U 2 1555
REMARK 465 A 2 1556
REMARK 465 C 2 1557
REMARK 465 G 2 1761
REMARK 465 U 2 1762
REMARK 465 C 2 1763
REMARK 465 G 2 1764
REMARK 465 G 2 1765
REMARK 465 C 2 1766
REMARK 465 C 2 1767
REMARK 465 C 2 1768
REMARK 465 A 2 1769
REMARK 465 C 2 1770
REMARK 465 G 2 1771
REMARK 465 G 2 1772
REMARK 465 C 3 109
REMARK 465 U 3 110
REMARK 465 U 3 111
REMARK 465 C 3 112
REMARK 465 G 3 113
REMARK 465 G 3 114
REMARK 465 C 3 115
REMARK 465 C 3 178
REMARK 465 A 3 179
REMARK 465 G 3 180
REMARK 465 G 3 181
REMARK 465 A 3 182
REMARK 465 C 3 183
REMARK 465 G 3 184
REMARK 465 A 3 185
REMARK 465 C 3 186
REMARK 465 C 3 187
REMARK 465 G 3 188
REMARK 465 G 3 189
REMARK 465 G 3 190
REMARK 465 U 3 191
REMARK 465 C 3 192
REMARK 465 C 3 193
REMARK 465 U 3 194
REMARK 465 U 3 195
REMARK 465 U 3 196
REMARK 465 C 3 197
REMARK 465 U 3 198
REMARK 465 U 3 199
REMARK 465 G 3 200
REMARK 465 G 3 201
REMARK 465 A 3 202
REMARK 465 U 3 203
REMARK 465 A 3 204
REMARK 465 A 3 205
REMARK 465 A 3 206
REMARK 465 C 3 207
REMARK 465 C 3 208
REMARK 465 C 3 209
REMARK 465 G 3 210
REMARK 465 C 3 211
REMARK 465 U 3 212
REMARK 465 C 3 213
REMARK 465 A 3 214
REMARK 465 A 3 215
REMARK 465 U 3 216
REMARK 465 G 3 217
REMARK 465 C 3 218
REMARK 465 C 3 219
REMARK 465 U 3 220
REMARK 465 G 3 221
REMARK 465 G 3 335
REMARK 465 U 3 336
REMARK 465 G 3 337
REMARK 465 C 3 338
REMARK 465 A 3 339
REMARK 465 C 3 340
REMARK 465 C 3 341
REMARK 465 A 3 345
REMARK 465 G 3 346
REMARK 465 C 3 347
REMARK 465 A 3 348
REMARK 465 C 3 349
REMARK 465 G 3 350
REMARK 465 A 3 351
REMARK 465 A 3 352
REMARK 465 U 3 353
REMARK 465 C 3 354
REMARK 465 C 3 355
REMARK 465 U 3 356
REMARK 465 A 3 357
REMARK 465 A 3 358
REMARK 465 A 3 359
REMARK 465 C 3 360
REMARK 465 C 3 361
REMARK 465 U 3 362
REMARK 465 C 3 363
REMARK 465 A 3 364
REMARK 465 A 3 365
REMARK 465 A 3 366
REMARK 465 G 3 367
REMARK 465 A 3 368
REMARK 465 A 3 369
REMARK 465 A 3 370
REMARK 465 A 3 371
REMARK 465 A 3 372
REMARK 465 G 3 373
REMARK 465 A 3 374
REMARK 465 U 3 375
REMARK 465 MET A 1
REMARK 465 ALA A 218
REMARK 465 GLU A 219
REMARK 465 LYS A 220
REMARK 465 ALA A 221
REMARK 465 VAL A 222
REMARK 465 THR A 223
REMARK 465 LYS A 224
REMARK 465 GLU A 225
REMARK 465 GLU A 226
REMARK 465 PHE A 227
REMARK 465 GLN A 228
REMARK 465 GLY A 229
REMARK 465 GLU A 230
REMARK 465 TRP A 231
REMARK 465 THR A 232
REMARK 465 ALA A 233
REMARK 465 PRO A 234
REMARK 465 ALA A 235
REMARK 465 PRO A 236
REMARK 465 GLU A 237
REMARK 465 PHE A 238
REMARK 465 THR A 239
REMARK 465 ALA A 240
REMARK 465 THR A 241
REMARK 465 GLN A 242
REMARK 465 PRO A 243
REMARK 465 GLU A 244
REMARK 465 VAL A 245
REMARK 465 ALA A 246
REMARK 465 ASP A 247
REMARK 465 TRP A 248
REMARK 465 SER A 249
REMARK 465 GLU A 250
REMARK 465 GLY A 251
REMARK 465 VAL A 252
REMARK 465 GLN A 253
REMARK 465 VAL A 254
REMARK 465 PRO A 255
REMARK 465 SER A 256
REMARK 465 VAL A 257
REMARK 465 PRO A 258
REMARK 465 ILE A 259
REMARK 465 GLN A 260
REMARK 465 GLN A 261
REMARK 465 PHE A 262
REMARK 465 PRO A 263
REMARK 465 THR A 264
REMARK 465 GLU A 265
REMARK 465 ASP A 266
REMARK 465 TRP A 267
REMARK 465 SER A 268
REMARK 465 ALA A 269
REMARK 465 GLN A 270
REMARK 465 PRO A 271
REMARK 465 ALA A 272
REMARK 465 THR A 273
REMARK 465 GLU A 274
REMARK 465 ASP A 275
REMARK 465 TRP A 276
REMARK 465 SER A 277
REMARK 465 ALA A 278
REMARK 465 ALA A 279
REMARK 465 PRO A 280
REMARK 465 THR A 281
REMARK 465 ALA A 282
REMARK 465 GLN A 283
REMARK 465 ALA A 284
REMARK 465 THR A 285
REMARK 465 GLU A 286
REMARK 465 TRP A 287
REMARK 465 VAL A 288
REMARK 465 GLY A 289
REMARK 465 ALA A 290
REMARK 465 THR A 291
REMARK 465 THR A 292
REMARK 465 ASP A 293
REMARK 465 TRP A 294
REMARK 465 SER A 295
REMARK 465 MET B 1
REMARK 465 ALA B 2
REMARK 465 VAL B 3
REMARK 465 GLY B 4
REMARK 465 LYS B 5
REMARK 465 ASN B 6
REMARK 465 LYS B 7
REMARK 465 ARG B 8
REMARK 465 LEU B 9
REMARK 465 THR B 10
REMARK 465 LYS B 11
REMARK 465 GLY B 12
REMARK 465 GLY B 13
REMARK 465 LYS B 14
REMARK 465 LYS B 15
REMARK 465 GLY B 16
REMARK 465 ALA B 17
REMARK 465 LYS B 18
REMARK 465 LYS B 19
REMARK 465 LYS B 20
REMARK 465 GLU B 234
REMARK 465 GLY B 235
REMARK 465 SER B 236
REMARK 465 SER B 237
REMARK 465 SER B 238
REMARK 465 GLY B 239
REMARK 465 LYS B 240
REMARK 465 ALA B 241
REMARK 465 THR B 242
REMARK 465 GLY B 243
REMARK 465 ASP B 244
REMARK 465 GLU B 245
REMARK 465 THR B 246
REMARK 465 GLY B 247
REMARK 465 ALA B 248
REMARK 465 LYS B 249
REMARK 465 VAL B 250
REMARK 465 GLU B 251
REMARK 465 ARG B 252
REMARK 465 ALA B 253
REMARK 465 ASP B 254
REMARK 465 GLY B 255
REMARK 465 TYR B 256
REMARK 465 GLU B 257
REMARK 465 PRO B 258
REMARK 465 PRO B 259
REMARK 465 VAL B 260
REMARK 465 GLN B 261
REMARK 465 GLU B 262
REMARK 465 SER B 263
REMARK 465 VAL B 264
REMARK 465 MET C 1
REMARK 465 ALA C 2
REMARK 465 ASP C 3
REMARK 465 ASP C 4
REMARK 465 ALA C 5
REMARK 465 GLY C 6
REMARK 465 ALA C 7
REMARK 465 ALA C 8
REMARK 465 GLY C 9
REMARK 465 GLY C 10
REMARK 465 PRO C 11
REMARK 465 GLY C 12
REMARK 465 GLY C 13
REMARK 465 PRO C 14
REMARK 465 GLY C 15
REMARK 465 GLY C 16
REMARK 465 PRO C 17
REMARK 465 GLY C 18
REMARK 465 MET C 19
REMARK 465 GLY C 20
REMARK 465 ASN C 21
REMARK 465 ARG C 22
REMARK 465 GLY C 23
REMARK 465 GLY C 24
REMARK 465 PHE C 25
REMARK 465 ARG C 26
REMARK 465 GLY C 27
REMARK 465 GLY C 28
REMARK 465 PHE C 29
REMARK 465 GLY C 30
REMARK 465 SER C 31
REMARK 465 GLY C 32
REMARK 465 ILE C 33
REMARK 465 ARG C 34
REMARK 465 GLY C 35
REMARK 465 ARG C 36
REMARK 465 GLY C 37
REMARK 465 ARG C 38
REMARK 465 GLY C 39
REMARK 465 ARG C 40
REMARK 465 GLY C 41
REMARK 465 ARG C 42
REMARK 465 GLY C 43
REMARK 465 ARG C 44
REMARK 465 GLY C 45
REMARK 465 ARG C 46
REMARK 465 GLY C 47
REMARK 465 ARG C 48
REMARK 465 GLY C 49
REMARK 465 ALA C 50
REMARK 465 ARG C 51
REMARK 465 GLY C 52
REMARK 465 GLY C 53
REMARK 465 LYS C 54
REMARK 465 ALA C 55
REMARK 465 GLU C 56
REMARK 465 ASP C 57
REMARK 465 LYS C 58
REMARK 465 HIS C 277
REMARK 465 THR C 278
REMARK 465 ARG C 279
REMARK 465 VAL C 280
REMARK 465 SER C 281
REMARK 465 VAL C 282
REMARK 465 GLN C 283
REMARK 465 ARG C 284
REMARK 465 THR C 285
REMARK 465 GLN C 286
REMARK 465 ALA C 287
REMARK 465 PRO C 288
REMARK 465 ALA C 289
REMARK 465 VAL C 290
REMARK 465 ALA C 291
REMARK 465 THR C 292
REMARK 465 THR C 293
REMARK 465 MET D 1
REMARK 465 ALA D 2
REMARK 465 GLY D 228
REMARK 465 GLY D 229
REMARK 465 LYS D 230
REMARK 465 PRO D 231
REMARK 465 GLU D 232
REMARK 465 PRO D 233
REMARK 465 PRO D 234
REMARK 465 ALA D 235
REMARK 465 MET D 236
REMARK 465 PRO D 237
REMARK 465 GLN D 238
REMARK 465 PRO D 239
REMARK 465 VAL D 240
REMARK 465 PRO D 241
REMARK 465 THR D 242
REMARK 465 ALA D 243
REMARK 465 MET E 1
REMARK 465 MET F 1
REMARK 465 THR F 2
REMARK 465 GLU F 3
REMARK 465 TRP F 4
REMARK 465 GLU F 5
REMARK 465 THR F 6
REMARK 465 ALA F 7
REMARK 465 ALA F 8
REMARK 465 PRO F 9
REMARK 465 ALA F 10
REMARK 465 VAL F 11
REMARK 465 ALA F 12
REMARK 465 GLU F 13
REMARK 465 THR F 14
REMARK 465 PRO F 15
REMARK 465 ARG G 231
REMARK 465 ARG G 232
REMARK 465 ARG G 233
REMARK 465 LEU G 234
REMARK 465 SER G 235
REMARK 465 SER G 236
REMARK 465 LEU G 237
REMARK 465 ARG G 238
REMARK 465 ALA G 239
REMARK 465 SER G 240
REMARK 465 THR G 241
REMARK 465 SER G 242
REMARK 465 LYS G 243
REMARK 465 SER G 244
REMARK 465 GLU G 245
REMARK 465 SER G 246
REMARK 465 SER G 247
REMARK 465 GLN G 248
REMARK 465 LYS G 249
REMARK 465 MET H 1
REMARK 465 PHE H 2
REMARK 465 SER H 3
REMARK 465 SER H 4
REMARK 465 SER H 5
REMARK 465 ALA H 6
REMARK 465 LYS H 7
REMARK 465 LEU H 194
REMARK 465 MET I 1
REMARK 465 GLY I 207
REMARK 465 LYS I 208
REMARK 465 MET J 1
REMARK 465 GLN J 182
REMARK 465 GLY J 183
REMARK 465 GLY J 184
REMARK 465 ALA J 185
REMARK 465 GLY J 186
REMARK 465 ALA J 187
REMARK 465 GLY J 188
REMARK 465 ASP J 189
REMARK 465 ASP J 190
REMARK 465 GLU J 191
REMARK 465 GLU J 192
REMARK 465 GLU J 193
REMARK 465 ASP J 194
REMARK 465 MET K 1
REMARK 465 LEU K 2
REMARK 465 ARG K 98
REMARK 465 PRO K 99
REMARK 465 GLU K 100
REMARK 465 THR K 101
REMARK 465 GLY K 102
REMARK 465 ARG K 103
REMARK 465 PRO K 104
REMARK 465 ARG K 105
REMARK 465 PRO K 106
REMARK 465 LYS K 107
REMARK 465 GLY K 108
REMARK 465 LEU K 109
REMARK 465 GLU K 110
REMARK 465 GLY K 111
REMARK 465 GLU K 112
REMARK 465 ARG K 113
REMARK 465 PRO K 114
REMARK 465 ALA K 115
REMARK 465 ARG K 116
REMARK 465 LEU K 117
REMARK 465 THR K 118
REMARK 465 ARG K 119
REMARK 465 GLY K 120
REMARK 465 GLU K 121
REMARK 465 ALA K 122
REMARK 465 ASP K 123
REMARK 465 ARG K 124
REMARK 465 ASP K 125
REMARK 465 THR K 126
REMARK 465 TYR K 127
REMARK 465 ARG K 128
REMARK 465 ARG K 129
REMARK 465 SER K 130
REMARK 465 ALA K 131
REMARK 465 VAL K 132
REMARK 465 PRO K 133
REMARK 465 PRO K 134
REMARK 465 GLY K 135
REMARK 465 ALA K 136
REMARK 465 ASP K 137
REMARK 465 LYS K 138
REMARK 465 LYS K 139
REMARK 465 ALA K 140
REMARK 465 GLU K 141
REMARK 465 ALA K 142
REMARK 465 GLY K 143
REMARK 465 ALA K 144
REMARK 465 GLY K 145
REMARK 465 SER K 146
REMARK 465 ALA K 147
REMARK 465 THR K 148
REMARK 465 GLU K 149
REMARK 465 PHE K 150
REMARK 465 GLN K 151
REMARK 465 PHE K 152
REMARK 465 ARG K 153
REMARK 465 GLY K 154
REMARK 465 GLY K 155
REMARK 465 PHE K 156
REMARK 465 GLY K 157
REMARK 465 ARG K 158
REMARK 465 GLY K 159
REMARK 465 ARG K 160
REMARK 465 GLY K 161
REMARK 465 GLN K 162
REMARK 465 PRO K 163
REMARK 465 PRO K 164
REMARK 465 GLN K 165
REMARK 465 MET L 1
REMARK 465 LYS L 153
REMARK 465 GLN L 154
REMARK 465 PHE L 155
REMARK 465 GLN L 156
REMARK 465 LYS L 157
REMARK 465 PHE L 158
REMARK 465 MET M 1
REMARK 465 ALA M 2
REMARK 465 GLU M 3
REMARK 465 GLU M 4
REMARK 465 GLY M 5
REMARK 465 ILE M 6
REMARK 465 ALA M 7
REMARK 465 ALA M 8
REMARK 465 GLY M 9
REMARK 465 MET N 1
REMARK 465 ALA N 151
REMARK 465 MET O 1
REMARK 465 ALA O 2
REMARK 465 PRO O 3
REMARK 465 ARG O 4
REMARK 465 LYS O 5
REMARK 465 GLY O 6
REMARK 465 LYS O 7
REMARK 465 GLU O 8
REMARK 465 LYS O 9
REMARK 465 LYS O 10
REMARK 465 GLU O 11
REMARK 465 GLU O 12
REMARK 465 GLN O 13
REMARK 465 VAL O 14
REMARK 465 ILE O 15
REMARK 465 SER O 16
REMARK 465 MET P 1
REMARK 465 ALA P 2
REMARK 465 GLU P 3
REMARK 465 VAL P 4
REMARK 465 GLU P 5
REMARK 465 GLN P 6
REMARK 465 LYS P 7
REMARK 465 LYS P 8
REMARK 465 LYS P 9
REMARK 465 ARG P 10
REMARK 465 THR P 11
REMARK 465 PHE P 12
REMARK 465 ARG P 13
REMARK 465 LYS P 14
REMARK 465 ALA P 135
REMARK 465 THR P 136
REMARK 465 HIS P 137
REMARK 465 SER P 138
REMARK 465 SER P 139
REMARK 465 ARG P 140
REMARK 465 PHE P 141
REMARK 465 ILE P 142
REMARK 465 PRO P 143
REMARK 465 LEU P 144
REMARK 465 LYS P 145
REMARK 465 MET Q 1
REMARK 465 PRO Q 2
REMARK 465 SER Q 3
REMARK 465 LYS Q 4
REMARK 465 GLY Q 5
REMARK 465 PRO Q 6
REMARK 465 LEU Q 7
REMARK 465 MET R 1
REMARK 465 PRO R 134
REMARK 465 VAL R 135
REMARK 465 MET S 1
REMARK 465 SER S 2
REMARK 465 VAL S 146
REMARK 465 GLY S 147
REMARK 465 VAL S 148
REMARK 465 SER S 149
REMARK 465 LYS S 150
REMARK 465 LYS S 151
REMARK 465 LYS S 152
REMARK 465 MET T 1
REMARK 465 MET U 1
REMARK 465 ALA U 2
REMARK 465 PHE U 3
REMARK 465 LYS U 4
REMARK 465 ASP U 5
REMARK 465 THR U 6
REMARK 465 GLY U 7
REMARK 465 LYS U 8
REMARK 465 THR U 9
REMARK 465 PRO U 10
REMARK 465 VAL U 11
REMARK 465 GLU U 12
REMARK 465 PRO U 13
REMARK 465 GLU U 14
REMARK 465 VAL U 15
REMARK 465 ALA U 16
REMARK 465 ASP U 118
REMARK 465 ALA U 119
REMARK 465 PHE V 83
REMARK 465 MET W 1
REMARK 465 MET X 1
REMARK 465 SER X 143
REMARK 465 MET Y 1
REMARK 465 ASN Y 2
REMARK 465 ALA Y 127
REMARK 465 GLY Y 128
REMARK 465 LYS Y 129
REMARK 465 LYS Y 130
REMARK 465 MET Z 1
REMARK 465 PRO Z 2
REMARK 465 PRO Z 3
REMARK 465 LYS Z 4
REMARK 465 ASP Z 5
REMARK 465 ASP Z 6
REMARK 465 LYS Z 7
REMARK 465 LYS Z 8
REMARK 465 LYS Z 9
REMARK 465 LYS Z 10
REMARK 465 ASP Z 11
REMARK 465 ALA Z 12
REMARK 465 GLY Z 13
REMARK 465 LYS Z 14
REMARK 465 SER Z 15
REMARK 465 ALA Z 16
REMARK 465 LYS Z 17
REMARK 465 LYS Z 18
REMARK 465 ASP Z 19
REMARK 465 LYS Z 20
REMARK 465 ASP Z 21
REMARK 465 PRO Z 22
REMARK 465 VAL Z 23
REMARK 465 ASN Z 24
REMARK 465 LYS Z 25
REMARK 465 SER Z 26
REMARK 465 GLY Z 27
REMARK 465 GLY Z 28
REMARK 465 LYS Z 29
REMARK 465 ALA Z 30
REMARK 465 LYS Z 31
REMARK 465 LYS Z 32
REMARK 465 LYS Z 33
REMARK 465 LYS Z 34
REMARK 465 TRP Z 35
REMARK 465 SER Z 36
REMARK 465 LYS Z 37
REMARK 465 GLY Z 38
REMARK 465 LYS Z 39
REMARK 465 VAL Z 40
REMARK 465 ARG Z 41
REMARK 465 LYS Z 114
REMARK 465 GLY Z 115
REMARK 465 GLY Z 116
REMARK 465 ASP Z 117
REMARK 465 ALA Z 118
REMARK 465 PRO Z 119
REMARK 465 ALA Z 120
REMARK 465 ALA Z 121
REMARK 465 GLY Z 122
REMARK 465 GLU Z 123
REMARK 465 ASP Z 124
REMARK 465 ALA Z 125
REMARK 465 MET g 1
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470 M RES CSSEQI ATOMS
REMARK 470 ARG I 141 CG CD NE CZ NH1 NH2
REMARK 470 SER I 142 OG
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE
REMARK 500 NZ LYS 0 9 OP1 U 2 966 1.92
REMARK 500 O TRP C 60 NZ LYS C 71 1.93
REMARK 500 O2' C 2 615 NH1 ARG e 8 1.94
REMARK 500 NH1 ARG E 11 OG1 THR E 24 2.03
REMARK 500 OH TYR A 37 NZ LYS A 57 2.05
REMARK 500 OP1 C 2 1075 NZ LYS N 107 2.06
REMARK 500 O2' A 2 1332 OE1 GLN D 145 2.07
REMARK 500 OP1 C 2 151 OG1 THR Y 120 2.08
REMARK 500 OP1 G 2 146 NZ LYS G 143 2.13
REMARK 500 OP1 U 2 943 NZ LYS B 214 2.14
REMARK 500 O5' A 2 1100 NH1 ARG R 132 2.14
REMARK 500 OP2 A 2 1661 NH1 ARG d 32 2.15
REMARK 500 O2' C 2 570 O THR Y 34 2.15
REMARK 500 O4 U 2 384 NH2 ARG I 5 2.15
REMARK 500 O2' C 2 168 O ARG G 132 2.15
REMARK 500 O PHE X 93 NH1 ARG X 140 2.17
REMARK 500 O2' G 2 1528 OP1 C 2 1666 2.17
REMARK 500 O2' A 2 1265 OP2 G 2 1327 2.17
REMARK 500 OD1 ASN D 22 OH TYR D 34 2.17
REMARK 500 OP2 A 2 68 NZ LYS G 164 2.17
REMARK 500 OP2 A 2 1863 NZ LYS a 4 2.18
REMARK 500 O2' A 2 1241 O2' C 2 1266 2.18
REMARK 500 OG1 THR B 129 OD1 ASP B 131 2.18
REMARK 500 OP2 A 2 919 NH1 ARG N 64 2.19
REMARK 500 O ILE I 3 N GLY I 30 2.19
REMARK 500 N2 G 2 1610 OD1 ASN S 85 2.19
REMARK 500 OG1 THR g 105 OD2 ASP g 126 2.19
REMARK 500 O2' U 2 943 O ILE O 135 2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION
REMARK 500 A 1 1 P A 1 1 OP3 -0.127
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3
REMARK 500 CYS 0 278 CA - CB - SG ANGL. DEV. = 7.8 DEGREES
REMARK 500 PRO 0 378 C - N - CA ANGL. DEV. = 13.8 DEGREES
REMARK 500 PRO 0 378 C - N - CD ANGL. DEV. = -13.4 DEGREES
REMARK 500 G 2 114 C3' - O3' - P ANGL. DEV. = 7.5 DEGREES
REMARK 500 C 2 382 C5 - C6 - N1 ANGL. DEV. = 3.5 DEGREES
REMARK 500 C 2 456 C6 - N1 - C2 ANGL. DEV. = -2.4 DEGREES
REMARK 500 C 2 501 N1 - C2 - O2 ANGL. DEV. = 5.2 DEGREES
REMARK 500 C 2 501 C6 - N1 - C1' ANGL. DEV. = -8.4 DEGREES
REMARK 500 C 2 501 C2 - N1 - C1' ANGL. DEV. = 9.6 DEGREES
REMARK 500 A 21253 C3' - O3' - P ANGL. DEV. = 8.3 DEGREES
REMARK 500 U 21314 C2 - N1 - C1' ANGL. DEV. = 9.2 DEGREES
REMARK 500 U 21602 O3' - P - OP2 ANGL. DEV. = 7.0 DEGREES
REMARK 500 C 21708 C6 - N1 - C1' ANGL. DEV. = -7.9 DEGREES
REMARK 500 C 21708 C2 - N1 - C1' ANGL. DEV. = 8.8 DEGREES
REMARK 500 U 21720 C5 - C6 - N1 ANGL. DEV. = 3.2 DEGREES
REMARK 500 U 21720 C2 - N1 - C1' ANGL. DEV. = 7.2 DEGREES
REMARK 500 G 21784 C4 - N9 - C1' ANGL. DEV. = 8.1 DEGREES
REMARK 500 G 21826 C3' - O3' - P ANGL. DEV. = 7.2 DEGREES
REMARK 500 U 21827 O3' - P - OP1 ANGL. DEV. = 7.5 DEGREES
REMARK 500 U 21827 C5 - C6 - N1 ANGL. DEV. = 3.7 DEGREES
REMARK 500 U 21827 C2 - N1 - C1' ANGL. DEV. = 8.4 DEGREES
REMARK 500 C 21828 C6 - N1 - C2 ANGL. DEV. = -2.4 DEGREES
REMARK 500 A 21835 C3' - O3' - P ANGL. DEV. = 7.4 DEGREES
REMARK 500 G 21836 O3' - P - OP1 ANGL. DEV. = 6.7 DEGREES
REMARK 500 U 21838 C3' - O3' - P ANGL. DEV. = 7.7 DEGREES
REMARK 500 LEU R 73 CA - CB - CG ANGL. DEV. = 16.6 DEGREES
REMARK 500 LEU R 73 CB - CG - CD2 ANGL. DEV. = -13.3 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 GLU 0 76 -3.45 57.23
REMARK 500 LEU 0 161 70.98 63.78
REMARK 500 LYS 0 277 -60.75 -105.70
REMARK 500 CYS 0 278 -164.85 -66.93
REMARK 500 LYS 0 281 -4.00 -57.75
REMARK 500 LYS 0 282 -2.00 89.21
REMARK 500 ALA 0 283 -122.24 50.37
REMARK 500 PRO 0 375 -179.40 -67.60
REMARK 500 PRO 0 379 150.14 -48.84
REMARK 500 THR 0 451 -66.68 -145.97
REMARK 500 ALA 0 499 -132.47 49.80
REMARK 500 ALA 0 540 -139.43 51.83
REMARK 500 LYS 0 541 -73.34 -132.78
REMARK 500 GLU 0 562 -61.15 -96.44
REMARK 500 ALA A 4 -1.71 67.90
REMARK 500 TYR A 39 -75.17 -100.84
REMARK 500 ASP A 158 -67.08 -101.79
REMARK 500 LYS A 166 -71.43 -79.63
REMARK 500 ILE A 189 -141.50 55.83
REMARK 500 GLU A 192 -64.84 -94.73
REMARK 500 ASP A 206 149.72 70.83
REMARK 500 GLU B 89 -62.64 -128.99
REMARK 500 HIS B 101 -62.72 -128.01
REMARK 500 LYS B 182 -72.26 -46.10
REMARK 500 ASP B 191 69.87 61.58
REMARK 500 TYR B 205 140.31 -176.75
REMARK 500 HIS B 208 -77.32 -115.22
REMARK 500 LEU B 218 -62.70 -99.95
REMARK 500 ASN C 134 -24.26 86.01
REMARK 500 SER C 190 -3.73 76.03
REMARK 500 SER C 206 -177.02 -170.99
REMARK 500 LYS D 62 -4.45 67.36
REMARK 500 HIS D 159 -70.03 -129.47
REMARK 500 ASP D 193 171.99 77.37
REMARK 500 LYS D 197 -5.57 84.95
REMARK 500 THR D 220 -68.58 -105.37
REMARK 500 ARG E 30 77.39 51.52
REMARK 500 LYS E 53 -0.72 67.28
REMARK 500 THR E 133 79.19 48.93
REMARK 500 ALA E 144 -2.30 68.69
REMARK 500 THR E 196 -62.29 -99.32
REMARK 500 PHE F 20 17.92 57.02
REMARK 500 LYS F 42 -67.13 -131.81
REMARK 500 GLU F 43 -71.22 -84.36
REMARK 500 TYR F 45 -19.05 -48.00
REMARK 500 ARG F 122 -60.35 -125.96
REMARK 500 PHE F 163 -74.61 -52.43
REMARK 500 ASP G 39 -61.67 -122.79
REMARK 500 TRP G 45 -70.47 -57.93
REMARK 500 LYS G 46 -113.42 53.47
REMARK 500
REMARK 500 THIS ENTRY HAS 141 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500 MODEL OMEGA
REMARK 500 ASP D 193 PRO D 194 -131.87
REMARK 500 ARG X 107 LYS X 108 141.20
REMARK 500
REMARK 500 REMARK: NULL
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN a 201 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS a 23 SG
REMARK 620 2 CYS a 26 SG 120.9
REMARK 620 3 CYS a 74 SG 106.3 108.1
REMARK 620 4 CYS a 77 SG 117.1 93.9 109.9
REMARK 620 N 1 2 3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN d 201 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS d 21 SG
REMARK 620 2 CYS d 24 SG 109.8
REMARK 620 3 CYS d 39 SG 108.9 105.5
REMARK 620 4 CYS d 42 SG 110.4 112.6 109.6
REMARK 620 N 1 2 3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN f 500 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS f 121 SG
REMARK 620 2 CYS f 126 SG 106.4
REMARK 620 3 CYS f 141 SG 110.0 110.4
REMARK 620 4 CYS f 144 SG 109.5 110.4 110.0
REMARK 620 N 1 2 3
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN a 201
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN d 201
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN f 500
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-3770 RELATED DB: EMDB
REMARK 900 HUMAN 40S-EIF2D-RE-INITIATION COMPLEX
DBREF 5OA3 0 1 584 UNP P41214 EIF2D_HUMAN 1 584
DBREF 5OA3 1 1 76 GB 176433 K00321.1 1 75
DBREF 5OA3 2 1 1869 GB 337376 M10098.1 102 1969
DBREF 5OA3 3 40 115 PDB 5OA3 5OA3 40 115
DBREF1 5OA3 3 116 372 GB KF279483.1
DBREF2 5OA3 3 555439351 47 303
DBREF 5OA3 3 373 375 PDB 5OA3 5OA3 373 375
DBREF 5OA3 A 1 295 UNP P08865 RSSA_HUMAN 1 295
DBREF 5OA3 B 1 264 UNP P61247 RS3A_HUMAN 1 264
DBREF 5OA3 C 1 293 UNP P15880 RS2_HUMAN 1 293
DBREF 5OA3 D 1 243 UNP P23396 RS3_HUMAN 1 243
DBREF 5OA3 E 1 263 UNP P62701 RS4X_HUMAN 1 263
DBREF 5OA3 F 1 204 UNP P46782 RS5_HUMAN 1 204
DBREF 5OA3 G 1 249 UNP P62753 RS6_HUMAN 1 249
DBREF 5OA3 H 1 194 UNP P62081 RS7_HUMAN 1 194
DBREF 5OA3 I 1 208 UNP P62241 RS8_HUMAN 1 208
DBREF 5OA3 J 1 194 UNP P46781 RS9_HUMAN 1 194
DBREF 5OA3 K 1 165 UNP P46783 RS10_HUMAN 1 165
DBREF 5OA3 L 1 158 UNP P62280 RS11_HUMAN 1 158
DBREF 5OA3 M 1 132 UNP P25398 RS12_HUMAN 1 132
DBREF 5OA3 N 1 151 UNP P62277 RS13_HUMAN 1 151
DBREF 5OA3 O 1 151 UNP P62263 RS14_HUMAN 1 151
DBREF 5OA3 P 1 145 UNP P62841 RS15_HUMAN 1 145
DBREF 5OA3 Q 1 146 UNP P62249 RS16_HUMAN 1 146
DBREF 5OA3 R 1 135 UNP P08708 RS17_HUMAN 1 135
DBREF 5OA3 S 1 152 UNP P62269 RS18_HUMAN 1 152
DBREF 5OA3 T 1 145 UNP P39019 RS19_HUMAN 1 145
DBREF 5OA3 U 1 119 UNP P60866 RS20_HUMAN 1 119
DBREF 5OA3 V 1 83 UNP P63220 RS21_HUMAN 1 83
DBREF 5OA3 W 1 130 UNP P62244 RS15A_HUMAN 1 130
DBREF 5OA3 X 1 143 UNP P62266 RS23_HUMAN 1 143
DBREF 5OA3 Y 1 130 UNP P62847 RS24_HUMAN 1 130
DBREF 5OA3 Z 1 125 UNP P62851 RS25_HUMAN 1 125
DBREF 5OA3 a 2 102 UNP P62854 RS26_HUMAN 2 102
DBREF 5OA3 b 2 83 UNP P42677 RS27_HUMAN 2 83
DBREF 5OA3 c 8 68 UNP P62857 RS28_HUMAN 8 68
DBREF 5OA3 d 2 56 UNP P62273 RS29_HUMAN 2 56
DBREF 5OA3 e 4 59 UNP P62861 RS30_HUMAN 4 59
DBREF 5OA3 f 78 149 UNP Q5RKT7 Q5RKT7_HUMAN 78 149
DBREF 5OA3 g 1 315 UNP P63244 RACK1_HUMAN 1 315
DBREF 5OA3 h 2 25 PDB 5OA3 5OA3 2 25
SEQRES 1 0 584 MET PHE ALA LYS ALA PHE ARG VAL LYS SER ASN THR ALA
SEQRES 2 0 584 ILE LYS GLY SER ASP ARG ARG LYS LEU ARG ALA ASP VAL
SEQRES 3 0 584 THR THR ALA PHE PRO THR LEU GLY THR ASP GLN VAL SER
SEQRES 4 0 584 GLU LEU VAL PRO GLY LYS GLU GLU LEU ASN ILE VAL LYS
SEQRES 5 0 584 LEU TYR ALA HIS LYS GLY ASP ALA VAL THR VAL TYR VAL
SEQRES 6 0 584 SER GLY GLY ASN PRO ILE LEU PHE GLU LEU GLU LYS ASN
SEQRES 7 0 584 LEU TYR PRO THR VAL TYR THR LEU TRP SER TYR PRO ASP
SEQRES 8 0 584 LEU LEU PRO THR PHE THR THR TRP PRO LEU VAL LEU GLU
SEQRES 9 0 584 LYS LEU VAL GLY GLY ALA ASP LEU MET LEU PRO GLY LEU
SEQRES 10 0 584 VAL MET PRO PRO ALA GLY LEU PRO GLN VAL GLN LYS GLY
SEQRES 11 0 584 ASP LEU CYS ALA ILE SER LEU VAL GLY ASN ARG ALA PRO
SEQRES 12 0 584 VAL ALA ILE GLY VAL ALA ALA MET SER THR ALA GLU MET
SEQRES 13 0 584 LEU THR SER GLY LEU LYS GLY ARG GLY PHE SER VAL LEU
SEQRES 14 0 584 HIS THR TYR GLN ASP HIS LEU TRP ARG SER GLY ASN LYS
SEQRES 15 0 584 SER SER PRO PRO SER ILE ALA PRO LEU ALA LEU ASP SER
SEQRES 16 0 584 ALA ASP LEU SER GLU GLU LYS GLY SER VAL GLN MET ASP
SEQRES 17 0 584 SER THR LEU GLN GLY ASP MET ARG HIS MET THR LEU GLU
SEQRES 18 0 584 GLY GLU GLU GLU ASN GLY GLU VAL HIS GLN ALA ARG GLU
SEQRES 19 0 584 ASP LYS SER LEU SER GLU ALA PRO GLU ASP THR SER THR
SEQRES 20 0 584 ARG GLY LEU ASN GLN ASP SER THR ASP SER LYS THR LEU
SEQRES 21 0 584 GLN GLU GLN MET ASP GLU LEU LEU GLN GLN CYS PHE LEU
SEQRES 22 0 584 HIS ALA LEU LYS CYS ARG VAL LYS LYS ALA ASP LEU PRO
SEQRES 23 0 584 LEU LEU THR SER THR PHE LEU GLY SER HIS MET PHE SER
SEQRES 24 0 584 CYS CYS PRO GLU GLY ARG GLN LEU ASP ILE LYS LYS SER
SEQRES 25 0 584 SER TYR LYS LYS LEU SER LYS PHE LEU GLN GLN MET GLN
SEQRES 26 0 584 GLN GLU GLN ILE ILE GLN VAL LYS GLU LEU SER LYS GLY
SEQRES 27 0 584 VAL GLU SER ILE VAL ALA VAL ASP TRP LYS HIS PRO ARG
SEQRES 28 0 584 ILE THR SER PHE VAL ILE PRO GLU PRO SER PRO THR SER
SEQRES 29 0 584 GLN THR ILE GLN GLU GLY SER ARG GLU GLN PRO TYR HIS
SEQRES 30 0 584 PRO PRO ASP ILE LYS PRO LEU TYR CYS VAL PRO ALA SER
SEQRES 31 0 584 MET THR LEU LEU PHE GLN GLU SER GLY HIS LYS LYS GLY
SEQRES 32 0 584 SER PHE LEU GLU GLY SER GLU VAL ARG THR ILE VAL ILE
SEQRES 33 0 584 ASN TYR ALA LYS LYS ASN ASP LEU VAL ASP ALA ASP ASN
SEQRES 34 0 584 LYS ASN LEU VAL ARG LEU ASP PRO ILE LEU CYS ASP CYS
SEQRES 35 0 584 ILE LEU GLU LYS ASN GLU GLN HIS THR VAL MET LYS LEU
SEQRES 36 0 584 PRO TRP ASP SER LEU LEU THR ARG CYS LEU GLU LYS LEU
SEQRES 37 0 584 GLN PRO ALA TYR GLN VAL THR LEU PRO GLY GLN GLU PRO
SEQRES 38 0 584 ILE VAL LYS LYS GLY ARG ILE CYS PRO ILE ASP ILE THR
SEQRES 39 0 584 LEU ALA GLN ARG ALA SER ASN LYS LYS VAL THR VAL VAL
SEQRES 40 0 584 ARG ASN LEU GLU ALA TYR GLY LEU ASP PRO TYR SER VAL
SEQRES 41 0 584 ALA ALA ILE LEU GLN GLN ARG CYS GLN ALA SER THR THR
SEQRES 42 0 584 VAL ASN PRO ALA PRO GLY ALA LYS ASP SER LEU GLN VAL
SEQRES 43 0 584 GLN ILE GLN GLY ASN GLN VAL HIS HIS LEU GLY TRP LEU
SEQRES 44 0 584 LEU LEU GLU GLU TYR GLN LEU PRO ARG LYS HIS ILE GLN
SEQRES 45 0 584 GLY LEU GLU LYS ALA LEU LYS PRO GLY LYS LYS LYS
SEQRES 1 1 75 A G C G C C G U G G C G C
SEQRES 2 1 75 A G U G G A A G C G C G C
SEQRES 3 1 75 A G G G C U C A U A A C C
SEQRES 4 1 75 C U G A U G U C C U C G G
SEQRES 5 1 75 A U C G A A A C C G A G C
SEQRES 6 1 75 G G C G C U A C C A
SEQRES 1 2 1868 U A C C U G G U U G A U C
SEQRES 2 2 1868 C U G C C A G U A G C A U
SEQRES 3 2 1868 A U G C U U G U C U C A A
SEQRES 4 2 1868 A G A U U A A G C C A U G
SEQRES 5 2 1868 C A U G U C U A A G U A C
SEQRES 6 2 1868 G C A C G G C C G G U A C
SEQRES 7 2 1868 A G U G A A A C U G C G A
SEQRES 8 2 1868 A U G G C U C A U U A A A
SEQRES 9 2 1868 U C A G U U A U G G U U C
SEQRES 10 2 1868 C U U U G G U C G C U C G
SEQRES 11 2 1868 C U C C U C U C C U A C U
SEQRES 12 2 1868 U G G A U A A C U G U G G
SEQRES 13 2 1868 U A A U U C U A G A G C U
SEQRES 14 2 1868 A A U A C A U G C C G A C
SEQRES 15 2 1868 G G G C G C U G A C C C C
SEQRES 16 2 1868 C U U C G C G G G G G G G
SEQRES 17 2 1868 A U G C G U G C A U U U A
SEQRES 18 2 1868 U C A G A U C A A A A C C
SEQRES 19 2 1868 A A C C C G G U C A G C C
SEQRES 20 2 1868 C C U C U C C G G C C C C
SEQRES 21 2 1868 G G C C G G G G G G C G G
SEQRES 22 2 1868 G C C G C G G C G G C U U
SEQRES 23 2 1868 U G G U G A C U C U A G A
SEQRES 24 2 1868 U A A C C U C G G G C C G
SEQRES 25 2 1868 A U C G C A C G C C C C C
SEQRES 26 2 1868 C G U G G C G G C G A C G
SEQRES 27 2 1868 A C C C A U U C G A A C G
SEQRES 28 2 1868 U C U G C C C U A U C A A
SEQRES 29 2 1868 C U U U C G A U G G U A G
SEQRES 30 2 1868 U C G C C G U G C C U A C
SEQRES 31 2 1868 C A U G G U G A C C A C G
SEQRES 32 2 1868 G G U G A C G G G G A A U
SEQRES 33 2 1868 C A G G G U U C G A U U C
SEQRES 34 2 1868 C G G A G A G G G A G C C
SEQRES 35 2 1868 U G A G A A A C G G C U A
SEQRES 36 2 1868 C C A C A U C C A A G G A
SEQRES 37 2 1868 A G G C A G C A G G C G C
SEQRES 38 2 1868 G C A A A U U A C C C A C
SEQRES 39 2 1868 U C C C G A C C C G G G G
SEQRES 40 2 1868 A G G U A G U G A C G A A
SEQRES 41 2 1868 A A A U A A C A A U A C A
SEQRES 42 2 1868 G G A C U C U U U C G A G
SEQRES 43 2 1868 G C C C U G U A A U U G G
SEQRES 44 2 1868 A A U G A G U C C A C U U
SEQRES 45 2 1868 U A A A U C C U U U A A C
SEQRES 46 2 1868 G A G G A U C C A U U G G
SEQRES 47 2 1868 A G G G C A A G U C U G G
SEQRES 48 2 1868 U G C C A G C A G C C G C
SEQRES 49 2 1868 G G U A A U U C C A G C U
SEQRES 50 2 1868 C C A A U A G C G U A U A
SEQRES 51 2 1868 U U A A A G U U G C U G C
SEQRES 52 2 1868 A G U U A A A A A G C U C
SEQRES 53 2 1868 G U A G U U G G A U C U U
SEQRES 54 2 1868 G G G A G C G G G C G G G
SEQRES 55 2 1868 C G G U C C G C C G C G A
SEQRES 56 2 1868 G G C G A G C C A C C G C
SEQRES 57 2 1868 C C G U C C C C G C C C C
SEQRES 58 2 1868 U U G C C U C U C G G C G
SEQRES 59 2 1868 C C C C C U C G A U G C U
SEQRES 60 2 1868 C U U A G C U G A G U G U
SEQRES 61 2 1868 C C C G C G G G G C C C G
SEQRES 62 2 1868 A A G C G U U U A C U U U
SEQRES 63 2 1868 G A A A A A A U U A G A G
SEQRES 64 2 1868 U G U U C A A A G C A G G
SEQRES 65 2 1868 C C C G A G C C G C C U G
SEQRES 66 2 1868 G A U A C C G C A G C U A
SEQRES 67 2 1868 G G A A U A A U G G A A U
SEQRES 68 2 1868 A G G A C C G C G G U U C
SEQRES 69 2 1868 U A U U U U G U U G G U U
SEQRES 70 2 1868 U U C G G A A C U G A G G
SEQRES 71 2 1868 C C A U G A U U A A G A G
SEQRES 72 2 1868 G G A C G G C C G G G G G
SEQRES 73 2 1868 C A U U C G U A U U G C G
SEQRES 74 2 1868 C C G C U A G A G G U G A
SEQRES 75 2 1868 A A U U C U U G G A C C G
SEQRES 76 2 1868 G C G C A A G A C G G A C
SEQRES 77 2 1868 C A G A G C G A A A G C A
SEQRES 78 2 1868 U U U G C C A A G A A U G
SEQRES 79 2 1868 U U U U C A U U A A U C A
SEQRES 80 2 1868 A G A A C G A A A G U C G
SEQRES 81 2 1868 G A G G U U C G A A G A C
SEQRES 82 2 1868 G A U C A G A U A C C G U
SEQRES 83 2 1868 C G U A G U U C C G A C C
SEQRES 84 2 1868 A U A A A C G A U G C C G
SEQRES 85 2 1868 A C C G G C G A U G C G G
SEQRES 86 2 1868 C G G C G U U A U U C C C
SEQRES 87 2 1868 A U G A C C C G C C G G G
SEQRES 88 2 1868 C A G C U U C C G G G A A
SEQRES 89 2 1868 A C C A A A G U C U U U G
SEQRES 90 2 1868 G G U U C C G G G G G G A
SEQRES 91 2 1868 G U A U G G U U G C A A A
SEQRES 92 2 1868 G C U G A A A C U U A A A
SEQRES 93 2 1868 G G A A U U G A C G G A A
SEQRES 94 2 1868 G G G C A C C A C C A G G
SEQRES 95 2 1868 A G U G G A G C C U G C G
SEQRES 96 2 1868 G C U U A A U U U G A C U
SEQRES 97 2 1868 C A A C A C G G G A A A C
SEQRES 98 2 1868 C U C A C C C G G C C C G
SEQRES 99 2 1868 G A C A C G G A C A G G A
SEQRES 100 2 1868 U U G A C A G A U U G A U
SEQRES 101 2 1868 A G C U C U U U C U C G A
SEQRES 102 2 1868 U U C C G U G G G U G G U
SEQRES 103 2 1868 G G U G C A U G G C C G U
SEQRES 104 2 1868 U C U U A G U U G G U G G
SEQRES 105 2 1868 A G C G A U U U G U C U G
SEQRES 106 2 1868 G U U A A U U C C G A U A
SEQRES 107 2 1868 A C G A A C G A G A C U C
SEQRES 108 2 1868 U G G C A U G C U A A C U
SEQRES 109 2 1868 A G U U A C G C G A C C C
SEQRES 110 2 1868 C C G A G C G G U C G G C
SEQRES 111 2 1868 G U C C C C C A A C U U C
SEQRES 112 2 1868 U U A G A G G G A C A A G
SEQRES 113 2 1868 U G G C G U U C A G C C A
SEQRES 114 2 1868 C C C G A G A U U G A G C
SEQRES 115 2 1868 A A U A A C A G G U C U G
SEQRES 116 2 1868 U G A U G C C C U U A G A
SEQRES 117 2 1868 U G U C C G G G G C U G C
SEQRES 118 2 1868 A C G C G C G C U A C A C
SEQRES 119 2 1868 U G A C U G G C U C A G C
SEQRES 120 2 1868 G U G U G C C U A C C C U
SEQRES 121 2 1868 A C G C C G G C A G G C G
SEQRES 122 2 1868 C G G G U A A C C C G U U
SEQRES 123 2 1868 G A A C C C C A U U C G U
SEQRES 124 2 1868 G A U G G G G A U C G G G
SEQRES 125 2 1868 G A U U G C A A U U A U U
SEQRES 126 2 1868 C C C C A U G A A C G A G
SEQRES 127 2 1868 G A A U U C C C A G U A A
SEQRES 128 2 1868 G U G C G G G U C A U A A
SEQRES 129 2 1868 G C U U G C G U U G A U U
SEQRES 130 2 1868 A A G U C C C U G C C C U
SEQRES 131 2 1868 U U G U A C A C A C C G C
SEQRES 132 2 1868 C C G U C G C U A C U A C
SEQRES 133 2 1868 C G A U U G G A U G G U U
SEQRES 134 2 1868 U A G U G A G G C C C U C
SEQRES 135 2 1868 G G A U C G G C C C C G C
SEQRES 136 2 1868 C G G G G U C G G C C C A
SEQRES 137 2 1868 C G G C C U G G C G G A G
SEQRES 138 2 1868 C G C U G A G A A G A C G
SEQRES 139 2 1868 G U C G A A C U U G A C U
SEQRES 140 2 1868 A U C U A G A G G A A G U
SEQRES 141 2 1868 A A A A G U C G U A A C A
SEQRES 142 2 1868 A G G U U U C C G U A G G
SEQRES 143 2 1868 U G A A C C U G C G G A A
SEQRES 144 2 1868 G G A U C A U U A
SEQRES 1 3 275 C U C C C C U G C U U C G
SEQRES 2 3 275 G C A G G A C C C C C C C
SEQRES 3 3 275 U C C C G G G A G A G C C
SEQRES 4 3 275 A U A G U G G U C U G C G
SEQRES 5 3 275 G A A C C G G U G A G U A
SEQRES 6 3 275 C A C C G G A A U U G C C
SEQRES 7 3 275 A G G A C G A C C G G G U
SEQRES 8 3 275 C C U U U C U U G G A U A
SEQRES 9 3 275 A A C C C G C U C A A U G
SEQRES 10 3 275 C C U G G A G A U U U G G
SEQRES 11 3 275 G C G U G C C C C C G C A
SEQRES 12 3 275 A G A C U G C U A G C C G
SEQRES 13 3 275 A G U A G U G U U G G G U
SEQRES 14 3 275 C G C G A A A G G C C U U
SEQRES 15 3 275 G U G G U A C U G C C U G
SEQRES 16 3 275 A U A G G G U G C U U G C
SEQRES 17 3 275 G A G U G C C C C G G G A
SEQRES 18 3 275 G G U C U C G U A G A C C
SEQRES 19 3 275 G U G C A C C A U G A G C
SEQRES 20 3 275 A C G A A U C C U A A A C
SEQRES 21 3 275 C U C A A A G A A A A A G
SEQRES 22 3 275 A U
SEQRES 1 A 295 MET SER GLY ALA LEU ASP VAL LEU GLN MET LYS GLU GLU
SEQRES 2 A 295 ASP VAL LEU LYS PHE LEU ALA ALA GLY THR HIS LEU GLY
SEQRES 3 A 295 GLY THR ASN LEU ASP PHE GLN MET GLU GLN TYR ILE TYR
SEQRES 4 A 295 LYS ARG LYS SER ASP GLY ILE TYR ILE ILE ASN LEU LYS
SEQRES 5 A 295 ARG THR TRP GLU LYS LEU LEU LEU ALA ALA ARG ALA ILE
SEQRES 6 A 295 VAL ALA ILE GLU ASN PRO ALA ASP VAL SER VAL ILE SER
SEQRES 7 A 295 SER ARG ASN THR GLY GLN ARG ALA VAL LEU LYS PHE ALA
SEQRES 8 A 295 ALA ALA THR GLY ALA THR PRO ILE ALA GLY ARG PHE THR
SEQRES 9 A 295 PRO GLY THR PHE THR ASN GLN ILE GLN ALA ALA PHE ARG
SEQRES 10 A 295 GLU PRO ARG LEU LEU VAL VAL THR ASP PRO ARG ALA ASP
SEQRES 11 A 295 HIS GLN PRO LEU THR GLU ALA SER TYR VAL ASN LEU PRO
SEQRES 12 A 295 THR ILE ALA LEU CYS ASN THR ASP SER PRO LEU ARG TYR
SEQRES 13 A 295 VAL ASP ILE ALA ILE PRO CYS ASN ASN LYS GLY ALA HIS
SEQRES 14 A 295 SER VAL GLY LEU MET TRP TRP MET LEU ALA ARG GLU VAL
SEQRES 15 A 295 LEU ARG MET ARG GLY THR ILE SER ARG GLU HIS PRO TRP
SEQRES 16 A 295 GLU VAL MET PRO ASP LEU TYR PHE TYR ARG ASP PRO GLU
SEQRES 17 A 295 GLU ILE GLU LYS GLU GLU GLN ALA ALA ALA GLU LYS ALA
SEQRES 18 A 295 VAL THR LYS GLU GLU PHE GLN GLY GLU TRP THR ALA PRO
SEQRES 19 A 295 ALA PRO GLU PHE THR ALA THR GLN PRO GLU VAL ALA ASP
SEQRES 20 A 295 TRP SER GLU GLY VAL GLN VAL PRO SER VAL PRO ILE GLN
SEQRES 21 A 295 GLN PHE PRO THR GLU ASP TRP SER ALA GLN PRO ALA THR
SEQRES 22 A 295 GLU ASP TRP SER ALA ALA PRO THR ALA GLN ALA THR GLU
SEQRES 23 A 295 TRP VAL GLY ALA THR THR ASP TRP SER
SEQRES 1 B 264 MET ALA VAL GLY LYS ASN LYS ARG LEU THR LYS GLY GLY
SEQRES 2 B 264 LYS LYS GLY ALA LYS LYS LYS VAL VAL ASP PRO PHE SER
SEQRES 3 B 264 LYS LYS ASP TRP TYR ASP VAL LYS ALA PRO ALA MET PHE
SEQRES 4 B 264 ASN ILE ARG ASN ILE GLY LYS THR LEU VAL THR ARG THR
SEQRES 5 B 264 GLN GLY THR LYS ILE ALA SER ASP GLY LEU LYS GLY ARG
SEQRES 6 B 264 VAL PHE GLU VAL SER LEU ALA ASP LEU GLN ASN ASP GLU
SEQRES 7 B 264 VAL ALA PHE ARG LYS PHE LYS LEU ILE THR GLU ASP VAL
SEQRES 8 B 264 GLN GLY LYS ASN CYS LEU THR ASN PHE HIS GLY MET ASP
SEQRES 9 B 264 LEU THR ARG ASP LYS MET CYS SER MET VAL LYS LYS TRP
SEQRES 10 B 264 GLN THR MET ILE GLU ALA HIS VAL ASP VAL LYS THR THR
SEQRES 11 B 264 ASP GLY TYR LEU LEU ARG LEU PHE CYS VAL GLY PHE THR
SEQRES 12 B 264 LYS LYS ARG ASN ASN GLN ILE ARG LYS THR SER TYR ALA
SEQRES 13 B 264 GLN HIS GLN GLN VAL ARG GLN ILE ARG LYS LYS MET MET
SEQRES 14 B 264 GLU ILE MET THR ARG GLU VAL GLN THR ASN ASP LEU LYS
SEQRES 15 B 264 GLU VAL VAL ASN LYS LEU ILE PRO ASP SER ILE GLY LYS
SEQRES 16 B 264 ASP ILE GLU LYS ALA CYS GLN SER ILE TYR PRO LEU HIS
SEQRES 17 B 264 ASP VAL PHE VAL ARG LYS VAL LYS MET LEU LYS LYS PRO
SEQRES 18 B 264 LYS PHE GLU LEU GLY LYS LEU MET GLU LEU HIS GLY GLU
SEQRES 19 B 264 GLY SER SER SER GLY LYS ALA THR GLY ASP GLU THR GLY
SEQRES 20 B 264 ALA LYS VAL GLU ARG ALA ASP GLY TYR GLU PRO PRO VAL
SEQRES 21 B 264 GLN GLU SER VAL
SEQRES 1 C 293 MET ALA ASP ASP ALA GLY ALA ALA GLY GLY PRO GLY GLY
SEQRES 2 C 293 PRO GLY GLY PRO GLY MET GLY ASN ARG GLY GLY PHE ARG
SEQRES 3 C 293 GLY GLY PHE GLY SER GLY ILE ARG GLY ARG GLY ARG GLY
SEQRES 4 C 293 ARG GLY ARG GLY ARG GLY ARG GLY ARG GLY ALA ARG GLY
SEQRES 5 C 293 GLY LYS ALA GLU ASP LYS GLU TRP MET PRO VAL THR LYS
SEQRES 6 C 293 LEU GLY ARG LEU VAL LYS ASP MET LYS ILE LYS SER LEU
SEQRES 7 C 293 GLU GLU ILE TYR LEU PHE SER LEU PRO ILE LYS GLU SER
SEQRES 8 C 293 GLU ILE ILE ASP PHE PHE LEU GLY ALA SER LEU LYS ASP
SEQRES 9 C 293 GLU VAL LEU LYS ILE MET PRO VAL GLN LYS GLN THR ARG
SEQRES 10 C 293 ALA GLY GLN ARG THR ARG PHE LYS ALA PHE VAL ALA ILE
SEQRES 11 C 293 GLY ASP TYR ASN GLY HIS VAL GLY LEU GLY VAL LYS CYS
SEQRES 12 C 293 SER LYS GLU VAL ALA THR ALA ILE ARG GLY ALA ILE ILE
SEQRES 13 C 293 LEU ALA LYS LEU SER ILE VAL PRO VAL ARG ARG GLY TYR
SEQRES 14 C 293 TRP GLY ASN LYS ILE GLY LYS PRO HIS THR VAL PRO CYS
SEQRES 15 C 293 LYS VAL THR GLY ARG CYS GLY SER VAL LEU VAL ARG LEU
SEQRES 16 C 293 ILE PRO ALA PRO ARG GLY THR GLY ILE VAL SER ALA PRO
SEQRES 17 C 293 VAL PRO LYS LYS LEU LEU MET MET ALA GLY ILE ASP ASP
SEQRES 18 C 293 CYS TYR THR SER ALA ARG GLY CYS THR ALA THR LEU GLY
SEQRES 19 C 293 ASN PHE ALA LYS ALA THR PHE ASP ALA ILE SER LYS THR
SEQRES 20 C 293 TYR SER TYR LEU THR PRO ASP LEU TRP LYS GLU THR VAL
SEQRES 21 C 293 PHE THR LYS SER PRO TYR GLN GLU PHE THR ASP HIS LEU
SEQRES 22 C 293 VAL LYS THR HIS THR ARG VAL SER VAL GLN ARG THR GLN
SEQRES 23 C 293 ALA PRO ALA VAL ALA THR THR
SEQRES 1 D 243 MET ALA VAL GLN ILE SER LYS LYS ARG LYS PHE VAL ALA
SEQRES 2 D 243 ASP GLY ILE PHE LYS ALA GLU LEU ASN GLU PHE LEU THR
SEQRES 3 D 243 ARG GLU LEU ALA GLU ASP GLY TYR SER GLY VAL GLU VAL
SEQRES 4 D 243 ARG VAL THR PRO THR ARG THR GLU ILE ILE ILE LEU ALA
SEQRES 5 D 243 THR ARG THR GLN ASN VAL LEU GLY GLU LYS GLY ARG ARG
SEQRES 6 D 243 ILE ARG GLU LEU THR ALA VAL VAL GLN LYS ARG PHE GLY
SEQRES 7 D 243 PHE PRO GLU GLY SER VAL GLU LEU TYR ALA GLU LYS VAL
SEQRES 8 D 243 ALA THR ARG GLY LEU CYS ALA ILE ALA GLN ALA GLU SER
SEQRES 9 D 243 LEU ARG TYR LYS LEU LEU GLY GLY LEU ALA VAL ARG ARG
SEQRES 10 D 243 ALA CYS TYR GLY VAL LEU ARG PHE ILE MET GLU SER GLY
SEQRES 11 D 243 ALA LYS GLY CYS GLU VAL VAL VAL SER GLY LYS LEU ARG
SEQRES 12 D 243 GLY GLN ARG ALA LYS SER MET LYS PHE VAL ASP GLY LEU
SEQRES 13 D 243 MET ILE HIS SER GLY ASP PRO VAL ASN TYR TYR VAL ASP
SEQRES 14 D 243 THR ALA VAL ARG HIS VAL LEU LEU ARG GLN GLY VAL LEU
SEQRES 15 D 243 GLY ILE LYS VAL LYS ILE MET LEU PRO TRP ASP PRO THR
SEQRES 16 D 243 GLY LYS ILE GLY PRO LYS LYS PRO LEU PRO ASP HIS VAL
SEQRES 17 D 243 SER ILE VAL GLU PRO LYS ASP GLU ILE LEU PRO THR THR
SEQRES 18 D 243 PRO ILE SER GLU GLN LYS GLY GLY LYS PRO GLU PRO PRO
SEQRES 19 D 243 ALA MET PRO GLN PRO VAL PRO THR ALA
SEQRES 1 E 263 MET ALA ARG GLY PRO LYS LYS HIS LEU LYS ARG VAL ALA
SEQRES 2 E 263 ALA PRO LYS HIS TRP MET LEU ASP LYS LEU THR GLY VAL
SEQRES 3 E 263 PHE ALA PRO ARG PRO SER THR GLY PRO HIS LYS LEU ARG
SEQRES 4 E 263 GLU CYS LEU PRO LEU ILE ILE PHE LEU ARG ASN ARG LEU
SEQRES 5 E 263 LYS TYR ALA LEU THR GLY ASP GLU VAL LYS LYS ILE CYS
SEQRES 6 E 263 MET GLN ARG PHE ILE LYS ILE ASP GLY LYS VAL ARG THR
SEQRES 7 E 263 ASP ILE THR TYR PRO ALA GLY PHE MET ASP VAL ILE SER
SEQRES 8 E 263 ILE ASP LYS THR GLY GLU ASN PHE ARG LEU ILE TYR ASP
SEQRES 9 E 263 THR LYS GLY ARG PHE ALA VAL HIS ARG ILE THR PRO GLU
SEQRES 10 E 263 GLU ALA LYS TYR LYS LEU CYS LYS VAL ARG LYS ILE PHE
SEQRES 11 E 263 VAL GLY THR LYS GLY ILE PRO HIS LEU VAL THR HIS ASP
SEQRES 12 E 263 ALA ARG THR ILE ARG TYR PRO ASP PRO LEU ILE LYS VAL
SEQRES 13 E 263 ASN ASP THR ILE GLN ILE ASP LEU GLU THR GLY LYS ILE
SEQRES 14 E 263 THR ASP PHE ILE LYS PHE ASP THR GLY ASN LEU CYS MET
SEQRES 15 E 263 VAL THR GLY GLY ALA ASN LEU GLY ARG ILE GLY VAL ILE
SEQRES 16 E 263 THR ASN ARG GLU ARG HIS PRO GLY SER PHE ASP VAL VAL
SEQRES 17 E 263 HIS VAL LYS ASP ALA ASN GLY ASN SER PHE ALA THR ARG
SEQRES 18 E 263 LEU SER ASN ILE PHE VAL ILE GLY LYS GLY ASN LYS PRO
SEQRES 19 E 263 TRP ILE SER LEU PRO ARG GLY LYS GLY ILE ARG LEU THR
SEQRES 20 E 263 ILE ALA GLU GLU ARG ASP LYS ARG LEU ALA ALA LYS GLN
SEQRES 21 E 263 SER SER GLY
SEQRES 1 F 204 MET THR GLU TRP GLU THR ALA ALA PRO ALA VAL ALA GLU
SEQRES 2 F 204 THR PRO ASP ILE LYS LEU PHE GLY LYS TRP SER THR ASP
SEQRES 3 F 204 ASP VAL GLN ILE ASN ASP ILE SER LEU GLN ASP TYR ILE
SEQRES 4 F 204 ALA VAL LYS GLU LYS TYR ALA LYS TYR LEU PRO HIS SER
SEQRES 5 F 204 ALA GLY ARG TYR ALA ALA LYS ARG PHE ARG LYS ALA GLN
SEQRES 6 F 204 CYS PRO ILE VAL GLU ARG LEU THR ASN SER MET MET MET
SEQRES 7 F 204 HIS GLY ARG ASN ASN GLY LYS LYS LEU MET THR VAL ARG
SEQRES 8 F 204 ILE VAL LYS HIS ALA PHE GLU ILE ILE HIS LEU LEU THR
SEQRES 9 F 204 GLY GLU ASN PRO LEU GLN VAL LEU VAL ASN ALA ILE ILE
SEQRES 10 F 204 ASN SER GLY PRO ARG GLU ASP SER THR ARG ILE GLY ARG
SEQRES 11 F 204 ALA GLY THR VAL ARG ARG GLN ALA VAL ASP VAL SER PRO
SEQRES 12 F 204 LEU ARG ARG VAL ASN GLN ALA ILE TRP LEU LEU CYS THR
SEQRES 13 F 204 GLY ALA ARG GLU ALA ALA PHE ARG ASN ILE LYS THR ILE
SEQRES 14 F 204 ALA GLU CYS LEU ALA ASP GLU LEU ILE ASN ALA ALA LYS
SEQRES 15 F 204 GLY SER SER ASN SER TYR ALA ILE LYS LYS LYS ASP GLU
SEQRES 16 F 204 LEU GLU ARG VAL ALA LYS SER ASN ARG
SEQRES 1 G 249 MET LYS LEU ASN ILE SER PHE PRO ALA THR GLY CYS GLN
SEQRES 2 G 249 LYS LEU ILE GLU VAL ASP ASP GLU ARG LYS LEU ARG THR
SEQRES 3 G 249 PHE TYR GLU LYS ARG MET ALA THR GLU VAL ALA ALA ASP
SEQRES 4 G 249 ALA LEU GLY GLU GLU TRP LYS GLY TYR VAL VAL ARG ILE
SEQRES 5 G 249 SER GLY GLY ASN ASP LYS GLN GLY PHE PRO MET LYS GLN
SEQRES 6 G 249 GLY VAL LEU THR HIS GLY ARG VAL ARG LEU LEU LEU SER
SEQRES 7 G 249 LYS GLY HIS SER CYS TYR ARG PRO ARG ARG THR GLY GLU
SEQRES 8 G 249 ARG LYS ARG LYS SER VAL ARG GLY CYS ILE VAL ASP ALA
SEQRES 9 G 249 ASN LEU SER VAL LEU ASN LEU VAL ILE VAL LYS LYS GLY
SEQRES 10 G 249 GLU LYS ASP ILE PRO GLY LEU THR ASP THR THR VAL PRO
SEQRES 11 G 249 ARG ARG LEU GLY PRO LYS ARG ALA SER ARG ILE ARG LYS
SEQRES 12 G 249 LEU PHE ASN LEU SER LYS GLU ASP ASP VAL ARG GLN TYR
SEQRES 13 G 249 VAL VAL ARG LYS PRO LEU ASN LYS GLU GLY LYS LYS PRO
SEQRES 14 G 249 ARG THR LYS ALA PRO LYS ILE GLN ARG LEU VAL THR PRO
SEQRES 15 G 249 ARG VAL LEU GLN HIS LYS ARG ARG ARG ILE ALA LEU LYS
SEQRES 16 G 249 LYS GLN ARG THR LYS LYS ASN LYS GLU GLU ALA ALA GLU
SEQRES 17 G 249 TYR ALA LYS LEU LEU ALA LYS ARG MET LYS GLU ALA LYS
SEQRES 18 G 249 GLU LYS ARG GLN GLU GLN ILE ALA LYS ARG ARG ARG LEU
SEQRES 19 G 249 SER SER LEU ARG ALA SER THR SER LYS SER GLU SER SER
SEQRES 20 G 249 GLN LYS
SEQRES 1 H 194 MET PHE SER SER SER ALA LYS ILE VAL LYS PRO ASN GLY
SEQRES 2 H 194 GLU LYS PRO ASP GLU PHE GLU SER GLY ILE SER GLN ALA
SEQRES 3 H 194 LEU LEU GLU LEU GLU MET ASN SER ASP LEU LYS ALA GLN
SEQRES 4 H 194 LEU ARG GLU LEU ASN ILE THR ALA ALA LYS GLU ILE GLU
SEQRES 5 H 194 VAL GLY GLY GLY ARG LYS ALA ILE ILE ILE PHE VAL PRO
SEQRES 6 H 194 VAL PRO GLN LEU LYS SER PHE GLN LYS ILE GLN VAL ARG
SEQRES 7 H 194 LEU VAL ARG GLU LEU GLU LYS LYS PHE SER GLY LYS HIS
SEQRES 8 H 194 VAL VAL PHE ILE ALA GLN ARG ARG ILE LEU PRO LYS PRO
SEQRES 9 H 194 THR ARG LYS SER ARG THR LYS ASN LYS GLN LYS ARG PRO
SEQRES 10 H 194 ARG SER ARG THR LEU THR ALA VAL HIS ASP ALA ILE LEU
SEQRES 11 H 194 GLU ASP LEU VAL PHE PRO SER GLU ILE VAL GLY LYS ARG
SEQRES 12 H 194 ILE ARG VAL LYS LEU ASP GLY SER ARG LEU ILE LYS VAL
SEQRES 13 H 194 HIS LEU ASP LYS ALA GLN GLN ASN ASN VAL GLU HIS LYS
SEQRES 14 H 194 VAL GLU THR PHE SER GLY VAL TYR LYS LYS LEU THR GLY
SEQRES 15 H 194 LYS ASP VAL ASN PHE GLU PHE PRO GLU PHE GLN LEU
SEQRES 1 I 208 MET GLY ILE SER ARG ASP ASN TRP HIS LYS ARG ARG LYS
SEQRES 2 I 208 THR GLY GLY LYS ARG LYS PRO TYR HIS LYS LYS ARG LYS
SEQRES 3 I 208 TYR GLU LEU GLY ARG PRO ALA ALA ASN THR LYS ILE GLY
SEQRES 4 I 208 PRO ARG ARG ILE HIS THR VAL ARG VAL ARG GLY GLY ASN
SEQRES 5 I 208 LYS LYS TYR ARG ALA LEU ARG LEU ASP VAL GLY ASN PHE
SEQRES 6 I 208 SER TRP GLY SER GLU CYS CYS THR ARG LYS THR ARG ILE
SEQRES 7 I 208 ILE ASP VAL VAL TYR ASN ALA SER ASN ASN GLU LEU VAL
SEQRES 8 I 208 ARG THR LYS THR LEU VAL LYS ASN CYS ILE VAL LEU ILE
SEQRES 9 I 208 ASP SER THR PRO TYR ARG GLN TRP TYR GLU SER HIS TYR
SEQRES 10 I 208 ALA LEU PRO LEU GLY ARG LYS LYS GLY ALA LYS LEU THR
SEQRES 11 I 208 PRO GLU GLU GLU GLU ILE LEU ASN LYS LYS ARG SER LYS
SEQRES 12 I 208 LYS ILE GLN LYS LYS TYR ASP GLU ARG LYS LYS ASN ALA
SEQRES 13 I 208 LYS ILE SER SER LEU LEU GLU GLU GLN PHE GLN GLN GLY
SEQRES 14 I 208 LYS LEU LEU ALA CYS ILE ALA SER ARG PRO GLY GLN CYS
SEQRES 15 I 208 GLY ARG ALA ASP GLY TYR VAL LEU GLU GLY LYS GLU LEU
SEQRES 16 I 208 GLU PHE TYR LEU ARG LYS ILE LYS ALA ARG LYS GLY LYS
SEQRES 1 J 194 MET PRO VAL ALA ARG SER TRP VAL CYS ARG LYS THR TYR
SEQRES 2 J 194 VAL THR PRO ARG ARG PRO PHE GLU LYS SER ARG LEU ASP
SEQRES 3 J 194 GLN GLU LEU LYS LEU ILE GLY GLU TYR GLY LEU ARG ASN
SEQRES 4 J 194 LYS ARG GLU VAL TRP ARG VAL LYS PHE THR LEU ALA LYS
SEQRES 5 J 194 ILE ARG LYS ALA ALA ARG GLU LEU LEU THR LEU ASP GLU
SEQRES 6 J 194 LYS ASP PRO ARG ARG LEU PHE GLU GLY ASN ALA LEU LEU
SEQRES 7 J 194 ARG ARG LEU VAL ARG ILE GLY VAL LEU ASP GLU GLY LYS
SEQRES 8 J 194 MET LYS LEU ASP TYR ILE LEU GLY LEU LYS ILE GLU ASP
SEQRES 9 J 194 PHE LEU GLU ARG ARG LEU GLN THR GLN VAL PHE LYS LEU
SEQRES 10 J 194 GLY LEU ALA LYS SER ILE HIS HIS ALA ARG VAL LEU ILE
SEQRES 11 J 194 ARG GLN ARG HIS ILE ARG VAL ARG LYS GLN VAL VAL ASN
SEQRES 12 J 194 ILE PRO SER PHE ILE VAL ARG LEU ASP SER GLN LYS HIS
SEQRES 13 J 194 ILE ASP PHE SER LEU ARG SER PRO TYR GLY GLY GLY ARG
SEQRES 14 J 194 PRO GLY ARG VAL LYS ARG LYS ASN ALA LYS LYS GLY GLN
SEQRES 15 J 194 GLY GLY ALA GLY ALA GLY ASP ASP GLU GLU GLU ASP
SEQRES 1 K 165 MET LEU MET PRO LYS LYS ASN ARG ILE ALA ILE TYR GLU
SEQRES 2 K 165 LEU LEU PHE LYS GLU GLY VAL MET VAL ALA LYS LYS ASP
SEQRES 3 K 165 VAL HIS MET PRO LYS HIS PRO GLU LEU ALA ASP LYS ASN
SEQRES 4 K 165 VAL PRO ASN LEU HIS VAL MET LYS ALA MET GLN SER LEU
SEQRES 5 K 165 LYS SER ARG GLY TYR VAL LYS GLU GLN PHE ALA TRP ARG
SEQRES 6 K 165 HIS PHE TYR TRP TYR LEU THR ASN GLU GLY ILE GLN TYR
SEQRES 7 K 165 LEU ARG ASP TYR LEU HIS LEU PRO PRO GLU ILE VAL PRO
SEQRES 8 K 165 ALA THR LEU ARG ARG SER ARG PRO GLU THR GLY ARG PRO
SEQRES 9 K 165 ARG PRO LYS GLY LEU GLU GLY GLU ARG PRO ALA ARG LEU
SEQRES 10 K 165 THR ARG GLY GLU ALA ASP ARG ASP THR TYR ARG ARG SER
SEQRES 11 K 165 ALA VAL PRO PRO GLY ALA ASP LYS LYS ALA GLU ALA GLY
SEQRES 12 K 165 ALA GLY SER ALA THR GLU PHE GLN PHE ARG GLY GLY PHE
SEQRES 13 K 165 GLY ARG GLY ARG GLY GLN PRO PRO GLN
SEQRES 1 L 158 MET ALA ASP ILE GLN THR GLU ARG ALA TYR GLN LYS GLN
SEQRES 2 L 158 PRO THR ILE PHE GLN ASN LYS LYS ARG VAL LEU LEU GLY
SEQRES 3 L 158 GLU THR GLY LYS GLU LYS LEU PRO ARG TYR TYR LYS ASN
SEQRES 4 L 158 ILE GLY LEU GLY PHE LYS THR PRO LYS GLU ALA ILE GLU
SEQRES 5 L 158 GLY THR TYR ILE ASP LYS LYS CYS PRO PHE THR GLY ASN
SEQRES 6 L 158 VAL SER ILE ARG GLY ARG ILE LEU SER GLY VAL VAL THR
SEQRES 7 L 158 LYS MET LYS MET GLN ARG THR ILE VAL ILE ARG ARG ASP
SEQRES 8 L 158 TYR LEU HIS TYR ILE ARG LYS TYR ASN ARG PHE GLU LYS
SEQRES 9 L 158 ARG HIS LYS ASN MET SER VAL HIS LEU SER PRO CYS PHE
SEQRES 10 L 158 ARG ASP VAL GLN ILE GLY ASP ILE VAL THR VAL GLY GLU
SEQRES 11 L 158 CYS ARG PRO LEU SER LYS THR VAL ARG PHE ASN VAL LEU
SEQRES 12 L 158 LYS VAL THR LYS ALA ALA GLY THR LYS LYS GLN PHE GLN
SEQRES 13 L 158 LYS PHE
SEQRES 1 M 132 MET ALA GLU GLU GLY ILE ALA ALA GLY GLY VAL MET ASP
SEQRES 2 M 132 VAL ASN THR ALA LEU GLN GLU VAL LEU LYS THR ALA LEU
SEQRES 3 M 132 ILE HIS ASP GLY LEU ALA ARG GLY ILE ARG GLU ALA ALA
SEQRES 4 M 132 LYS ALA LEU ASP LYS ARG GLN ALA HIS LEU CYS VAL LEU
SEQRES 5 M 132 ALA SER ASN CYS ASP GLU PRO MET TYR VAL LYS LEU VAL
SEQRES 6 M 132 GLU ALA LEU CYS ALA GLU HIS GLN ILE ASN LEU ILE LYS
SEQRES 7 M 132 VAL ASP ASP ASN LYS LYS LEU GLY GLU TRP VAL GLY LEU
SEQRES 8 M 132 CYS LYS ILE ASP ARG GLU GLY LYS PRO ARG LYS VAL VAL
SEQRES 9 M 132 GLY CYS SER CYS VAL VAL VAL LYS ASP TYR GLY LYS GLU
SEQRES 10 M 132 SER GLN ALA LYS ASP VAL ILE GLU GLU TYR PHE LYS CYS
SEQRES 11 M 132 LYS LYS
SEQRES 1 N 151 MET GLY ARG MET HIS ALA PRO GLY LYS GLY LEU SER GLN
SEQRES 2 N 151 SER ALA LEU PRO TYR ARG ARG SER VAL PRO THR TRP LEU
SEQRES 3 N 151 LYS LEU THR SER ASP ASP VAL LYS GLU GLN ILE TYR LYS
SEQRES 4 N 151 LEU ALA LYS LYS GLY LEU THR PRO SER GLN ILE GLY VAL
SEQRES 5 N 151 ILE LEU ARG ASP SER HIS GLY VAL ALA GLN VAL ARG PHE
SEQRES 6 N 151 VAL THR GLY ASN LYS ILE LEU ARG ILE LEU LYS SER LYS
SEQRES 7 N 151 GLY LEU ALA PRO ASP LEU PRO GLU ASP LEU TYR HIS LEU
SEQRES 8 N 151 ILE LYS LYS ALA VAL ALA VAL ARG LYS HIS LEU GLU ARG
SEQRES 9 N 151 ASN ARG LYS ASP LYS ASP ALA LYS PHE ARG LEU ILE LEU
SEQRES 10 N 151 ILE GLU SER ARG ILE HIS ARG LEU ALA ARG TYR TYR LYS
SEQRES 11 N 151 THR LYS ARG VAL LEU PRO PRO ASN TRP LYS TYR GLU SER
SEQRES 12 N 151 SER THR ALA SER ALA LEU VAL ALA
SEQRES 1 O 151 MET ALA PRO ARG LYS GLY LYS GLU LYS LYS GLU GLU GLN
SEQRES 2 O 151 VAL ILE SER LEU GLY PRO GLN VAL ALA GLU GLY GLU ASN
SEQRES 3 O 151 VAL PHE GLY VAL CYS HIS ILE PHE ALA SER PHE ASN ASP
SEQRES 4 O 151 THR PHE VAL HIS VAL THR ASP LEU SER GLY LYS GLU THR
SEQRES 5 O 151 ILE CYS ARG VAL THR GLY GLY MET LYS VAL LYS ALA ASP
SEQRES 6 O 151 ARG ASP GLU SER SER PRO TYR ALA ALA MET LEU ALA ALA
SEQRES 7 O 151 GLN ASP VAL ALA GLN ARG CYS LYS GLU LEU GLY ILE THR
SEQRES 8 O 151 ALA LEU HIS ILE LYS LEU ARG ALA THR GLY GLY ASN ARG
SEQRES 9 O 151 THR LYS THR PRO GLY PRO GLY ALA GLN SER ALA LEU ARG
SEQRES 10 O 151 ALA LEU ALA ARG SER GLY MET LYS ILE GLY ARG ILE GLU
SEQRES 11 O 151 ASP VAL THR PRO ILE PRO SER ASP SER THR ARG ARG LYS
SEQRES 12 O 151 GLY GLY ARG ARG GLY ARG ARG LEU
SEQRES 1 P 145 MET ALA GLU VAL GLU GLN LYS LYS LYS ARG THR PHE ARG
SEQRES 2 P 145 LYS PHE THR TYR ARG GLY VAL ASP LEU ASP GLN LEU LEU
SEQRES 3 P 145 ASP MET SER TYR GLU GLN LEU MET GLN LEU TYR SER ALA
SEQRES 4 P 145 ARG GLN ARG ARG ARG LEU ASN ARG GLY LEU ARG ARG LYS
SEQRES 5 P 145 GLN HIS SER LEU LEU LYS ARG LEU ARG LYS ALA LYS LYS
SEQRES 6 P 145 GLU ALA PRO PRO MET GLU LYS PRO GLU VAL VAL LYS THR
SEQRES 7 P 145 HIS LEU ARG ASP MET ILE ILE LEU PRO GLU MET VAL GLY
SEQRES 8 P 145 SER MET VAL GLY VAL TYR ASN GLY LYS THR PHE ASN GLN
SEQRES 9 P 145 VAL GLU ILE LYS PRO GLU MET ILE GLY HIS TYR LEU GLY
SEQRES 10 P 145 GLU PHE SER ILE THR TYR LYS PRO VAL LYS HIS GLY ARG
SEQRES 11 P 145 PRO GLY ILE GLY ALA THR HIS SER SER ARG PHE ILE PRO
SEQRES 12 P 145 LEU LYS
SEQRES 1 Q 146 MET PRO SER LYS GLY PRO LEU GLN SER VAL GLN VAL PHE
SEQRES 2 Q 146 GLY ARG LYS LYS THR ALA THR ALA VAL ALA HIS CYS LYS
SEQRES 3 Q 146 ARG GLY ASN GLY LEU ILE LYS VAL ASN GLY ARG PRO LEU
SEQRES 4 Q 146 GLU MET ILE GLU PRO ARG THR LEU GLN TYR LYS LEU LEU
SEQRES 5 Q 146 GLU PRO VAL LEU LEU LEU GLY LYS GLU ARG PHE ALA GLY
SEQRES 6 Q 146 VAL ASP ILE ARG VAL ARG VAL LYS GLY GLY GLY HIS VAL
SEQRES 7 Q 146 ALA GLN ILE TYR ALA ILE ARG GLN SER ILE SER LYS ALA
SEQRES 8 Q 146 LEU VAL ALA TYR TYR GLN LYS TYR VAL ASP GLU ALA SER
SEQRES 9 Q 146 LYS LYS GLU ILE LYS ASP ILE LEU ILE GLN TYR ASP ARG
SEQRES 10 Q 146 THR LEU LEU VAL ALA ASP PRO ARG ARG CYS GLU SER LYS
SEQRES 11 Q 146 LYS PHE GLY GLY PRO GLY ALA ARG ALA ARG TYR GLN LYS
SEQRES 12 Q 146 SER TYR ARG
SEQRES 1 R 135 MET GLY ARG VAL ARG THR LYS THR VAL LYS LYS ALA ALA
SEQRES 2 R 135 ARG VAL ILE ILE GLU LYS TYR TYR THR ARG LEU GLY ASN
SEQRES 3 R 135 ASP PHE HIS THR ASN LYS ARG VAL CYS GLU GLU ILE ALA
SEQRES 4 R 135 ILE ILE PRO SER LYS LYS LEU ARG ASN LYS ILE ALA GLY
SEQRES 5 R 135 TYR VAL THR HIS LEU MET LYS ARG ILE GLN ARG GLY PRO
SEQRES 6 R 135 VAL ARG GLY ILE SER ILE LYS LEU GLN GLU GLU GLU ARG
SEQRES 7 R 135 GLU ARG ARG ASP ASN TYR VAL PRO GLU VAL SER ALA LEU
SEQRES 8 R 135 ASP GLN GLU ILE ILE GLU VAL ASP PRO ASP THR LYS GLU
SEQRES 9 R 135 MET LEU LYS LEU LEU ASP PHE GLY SER LEU SER ASN LEU
SEQRES 10 R 135 GLN VAL THR GLN PRO THR VAL GLY MET ASN PHE LYS THR
SEQRES 11 R 135 PRO ARG GLY PRO VAL
SEQRES 1 S 152 MET SER LEU VAL ILE PRO GLU LYS PHE GLN HIS ILE LEU
SEQRES 2 S 152 ARG VAL LEU ASN THR ASN ILE ASP GLY ARG ARG LYS ILE
SEQRES 3 S 152 ALA PHE ALA ILE THR ALA ILE LYS GLY VAL GLY ARG ARG
SEQRES 4 S 152 TYR ALA HIS VAL VAL LEU ARG LYS ALA ASP ILE ASP LEU
SEQRES 5 S 152 THR LYS ARG ALA GLY GLU LEU THR GLU ASP GLU VAL GLU
SEQRES 6 S 152 ARG VAL ILE THR ILE MET GLN ASN PRO ARG GLN TYR LYS
SEQRES 7 S 152 ILE PRO ASP TRP PHE LEU ASN ARG GLN LYS ASP VAL LYS
SEQRES 8 S 152 ASP GLY LYS TYR SER GLN VAL LEU ALA ASN GLY LEU ASP
SEQRES 9 S 152 ASN LYS LEU ARG GLU ASP LEU GLU ARG LEU LYS LYS ILE
SEQRES 10 S 152 ARG ALA HIS ARG GLY LEU ARG HIS PHE TRP GLY LEU ARG
SEQRES 11 S 152 VAL ARG GLY GLN HIS THR LYS THR THR GLY ARG ARG GLY
SEQRES 12 S 152 ARG THR VAL GLY VAL SER LYS LYS LYS
SEQRES 1 T 145 MET PRO GLY VAL THR VAL LYS ASP VAL ASN GLN GLN GLU
SEQRES 2 T 145 PHE VAL ARG ALA LEU ALA ALA PHE LEU LYS LYS SER GLY
SEQRES 3 T 145 LYS LEU LYS VAL PRO GLU TRP VAL ASP THR VAL LYS LEU
SEQRES 4 T 145 ALA LYS HIS LYS GLU LEU ALA PRO TYR ASP GLU ASN TRP
SEQRES 5 T 145 PHE TYR THR ARG ALA ALA SER THR ALA ARG HIS LEU TYR
SEQRES 6 T 145 LEU ARG GLY GLY ALA GLY VAL GLY SER MET THR LYS ILE
SEQRES 7 T 145 TYR GLY GLY ARG GLN ARG ASN GLY VAL MET PRO SER HIS
SEQRES 8 T 145 PHE SER ARG GLY SER LYS SER VAL ALA ARG ARG VAL LEU
SEQRES 9 T 145 GLN ALA LEU GLU GLY LEU LYS MET VAL GLU LYS ASP GLN
SEQRES 10 T 145 ASP GLY GLY ARG LYS LEU THR PRO GLN GLY GLN ARG ASP
SEQRES 11 T 145 LEU ASP ARG ILE ALA GLY GLN VAL ALA ALA ALA ASN LYS
SEQRES 12 T 145 LYS HIS
SEQRES 1 U 119 MET ALA PHE LYS ASP THR GLY LYS THR PRO VAL GLU PRO
SEQRES 2 U 119 GLU VAL ALA ILE HIS ARG ILE ARG ILE THR LEU THR SER
SEQRES 3 U 119 ARG ASN VAL LYS SER LEU GLU LYS VAL CYS ALA ASP LEU
SEQRES 4 U 119 ILE ARG GLY ALA LYS GLU LYS ASN LEU LYS VAL LYS GLY
SEQRES 5 U 119 PRO VAL ARG MET PRO THR LYS THR LEU ARG ILE THR THR
SEQRES 6 U 119 ARG LYS THR PRO CYS GLY GLU GLY SER LYS THR TRP ASP
SEQRES 7 U 119 ARG PHE GLN MET ARG ILE HIS LYS ARG LEU ILE ASP LEU
SEQRES 8 U 119 HIS SER PRO SER GLU ILE VAL LYS GLN ILE THR SER ILE
SEQRES 9 U 119 SER ILE GLU PRO GLY VAL GLU VAL GLU VAL THR ILE ALA
SEQRES 10 U 119 ASP ALA
SEQRES 1 V 83 MET GLN ASN ASP ALA GLY GLU PHE VAL ASP LEU TYR VAL
SEQRES 2 V 83 PRO ARG LYS CYS SER ALA SER ASN ARG ILE ILE GLY ALA
SEQRES 3 V 83 LYS ASP HIS ALA SER ILE GLN MET ASN VAL ALA GLU VAL
SEQRES 4 V 83 ASP LYS VAL THR GLY ARG PHE ASN GLY GLN PHE LYS THR
SEQRES 5 V 83 TYR ALA ILE CYS GLY ALA ILE ARG ARG MET GLY GLU SER
SEQRES 6 V 83 ASP ASP SER ILE LEU ARG LEU ALA LYS ALA ASP GLY ILE
SEQRES 7 V 83 VAL SER LYS ASN PHE
SEQRES 1 W 130 MET VAL ARG MET ASN VAL LEU ALA ASP ALA LEU LYS SER
SEQRES 2 W 130 ILE ASN ASN ALA GLU LYS ARG GLY LYS ARG GLN VAL LEU
SEQRES 3 W 130 ILE ARG PRO CYS SER LYS VAL ILE VAL ARG PHE LEU THR
SEQRES 4 W 130 VAL MET MET LYS HIS GLY TYR ILE GLY GLU PHE GLU ILE
SEQRES 5 W 130 ILE ASP ASP HIS ARG ALA GLY LYS ILE VAL VAL ASN LEU
SEQRES 6 W 130 THR GLY ARG LEU ASN LYS CYS GLY VAL ILE SER PRO ARG
SEQRES 7 W 130 PHE ASP VAL GLN LEU LYS ASP LEU GLU LYS TRP GLN ASN
SEQRES 8 W 130 ASN LEU LEU PRO SER ARG GLN PHE GLY PHE ILE VAL LEU
SEQRES 9 W 130 THR THR SER ALA GLY ILE MET ASP HIS GLU GLU ALA ARG
SEQRES 10 W 130 ARG LYS HIS THR GLY GLY LYS ILE LEU GLY PHE PHE PHE
SEQRES 1 X 143 MET GLY LYS CYS ARG GLY LEU ARG THR ALA ARG LYS LEU
SEQRES 2 X 143 ARG SER HIS ARG ARG ASP GLN LYS TRP HIS ASP LYS GLN
SEQRES 3 X 143 TYR LYS LYS ALA HIS LEU GLY THR ALA LEU LYS ALA ASN
SEQRES 4 X 143 PRO PHE GLY GLY ALA SER HIS ALA LYS GLY ILE VAL LEU
SEQRES 5 X 143 GLU LYS VAL GLY VAL GLU ALA LYS GLN PRO ASN SER ALA
SEQRES 6 X 143 ILE ARG LYS CYS VAL ARG VAL GLN LEU ILE LYS ASN GLY
SEQRES 7 X 143 LYS LYS ILE THR ALA PHE VAL PRO ASN ASP GLY CYS LEU
SEQRES 8 X 143 ASN PHE ILE GLU GLU ASN ASP GLU VAL LEU VAL ALA GLY
SEQRES 9 X 143 PHE GLY ARG LYS GLY HIS ALA VAL GLY ASP ILE PRO GLY
SEQRES 10 X 143 VAL ARG PHE LYS VAL VAL LYS VAL ALA ASN VAL SER LEU
SEQRES 11 X 143 LEU ALA LEU TYR LYS GLY LYS LYS GLU ARG PRO ARG SER
SEQRES 1 Y 130 MET ASN ASP THR VAL THR ILE ARG THR ARG LYS PHE MET
SEQRES 2 Y 130 THR ASN ARG LEU LEU GLN ARG LYS GLN MET VAL ILE ASP
SEQRES 3 Y 130 VAL LEU HIS PRO GLY LYS ALA THR VAL PRO LYS THR GLU
SEQRES 4 Y 130 ILE ARG GLU LYS LEU ALA LYS MET TYR LYS THR THR PRO
SEQRES 5 Y 130 ASP VAL ILE PHE VAL PHE GLY PHE ARG THR HIS PHE GLY
SEQRES 6 Y 130 GLY GLY LYS THR THR GLY PHE GLY MET ILE TYR ASP SER
SEQRES 7 Y 130 LEU ASP TYR ALA LYS LYS ASN GLU PRO LYS HIS ARG LEU
SEQRES 8 Y 130 ALA ARG HIS GLY LEU TYR GLU LYS LYS LYS THR SER ARG
SEQRES 9 Y 130 LYS GLN ARG LYS GLU ARG LYS ASN ARG MET LYS LYS VAL
SEQRES 10 Y 130 ARG GLY THR ALA LYS ALA ASN VAL GLY ALA GLY LYS LYS
SEQRES 1 Z 125 MET PRO PRO LYS ASP ASP LYS LYS LYS LYS ASP ALA GLY
SEQRES 2 Z 125 LYS SER ALA LYS LYS ASP LYS ASP PRO VAL ASN LYS SER
SEQRES 3 Z 125 GLY GLY LYS ALA LYS LYS LYS LYS TRP SER LYS GLY LYS
SEQRES 4 Z 125 VAL ARG ASP LYS LEU ASN ASN LEU VAL LEU PHE ASP LYS
SEQRES 5 Z 125 ALA THR TYR ASP LYS LEU CYS LYS GLU VAL PRO ASN TYR
SEQRES 6 Z 125 LYS LEU ILE THR PRO ALA VAL VAL SER GLU ARG LEU LYS
SEQRES 7 Z 125 ILE ARG GLY SER LEU ALA ARG ALA ALA LEU GLN GLU LEU
SEQRES 8 Z 125 LEU SER LYS GLY LEU ILE LYS LEU VAL SER LYS HIS ARG
SEQRES 9 Z 125 ALA GLN VAL ILE TYR THR ARG ASN THR LYS GLY GLY ASP
SEQRES 10 Z 125 ALA PRO ALA ALA GLY GLU ASP ALA
SEQRES 1 a 101 THR LYS LYS ARG ARG ASN ASN GLY ARG ALA LYS LYS GLY
SEQRES 2 a 101 ARG GLY HIS VAL GLN PRO ILE ARG CYS THR ASN CYS ALA
SEQRES 3 a 101 ARG CYS VAL PRO LYS ASP LYS ALA ILE LYS LYS PHE VAL
SEQRES 4 a 101 ILE ARG ASN ILE VAL GLU ALA ALA ALA VAL ARG ASP ILE
SEQRES 5 a 101 SER GLU ALA SER VAL PHE ASP ALA TYR VAL LEU PRO LYS
SEQRES 6 a 101 LEU TYR VAL LYS LEU HIS TYR CYS VAL SER CYS ALA ILE
SEQRES 7 a 101 HIS SER LYS VAL VAL ARG ASN ARG SER ARG GLU ALA ARG
SEQRES 8 a 101 LYS ASP ARG THR PRO PRO PRO ARG PHE ARG
SEQRES 1 b 82 PRO LEU ALA LYS ASP LEU LEU HIS PRO SER PRO GLU GLU
SEQRES 2 b 82 GLU LYS ARG LYS HIS LYS LYS LYS ARG LEU VAL GLN SER
SEQRES 3 b 82 PRO ASN SER TYR PHE MET ASP VAL LYS CYS PRO GLY CYS
SEQRES 4 b 82 TYR LYS ILE THR THR VAL PHE SER HIS ALA GLN THR VAL
SEQRES 5 b 82 VAL LEU CYS VAL GLY CYS SER THR VAL LEU CYS GLN PRO
SEQRES 6 b 82 THR GLY GLY LYS ALA ARG LEU THR GLU GLY CYS SER PHE
SEQRES 7 b 82 ARG ARG LYS GLN
SEQRES 1 c 61 PRO ILE LYS LEU ALA ARG VAL THR LYS VAL LEU GLY ARG
SEQRES 2 c 61 THR GLY SER GLN GLY GLN CYS THR GLN VAL ARG VAL GLU
SEQRES 3 c 61 PHE MET ASP ASP THR SER ARG SER ILE ILE ARG ASN VAL
SEQRES 4 c 61 LYS GLY PRO VAL ARG GLU GLY ASP VAL LEU THR LEU LEU
SEQRES 5 c 61 GLU SER GLU ARG GLU ALA ARG ARG LEU
SEQRES 1 d 55 GLY HIS GLN GLN LEU TYR TRP SER HIS PRO ARG LYS PHE
SEQRES 2 d 55 GLY GLN GLY SER ARG SER CYS ARG VAL CYS SER ASN ARG
SEQRES 3 d 55 HIS GLY LEU ILE ARG LYS TYR GLY LEU ASN MET CYS ARG
SEQRES 4 d 55 GLN CYS PHE ARG GLN TYR ALA LYS ASP ILE GLY PHE ILE
SEQRES 5 d 55 LYS LEU ASP
SEQRES 1 e 56 GLY SER LEU ALA ARG ALA GLY LYS VAL ARG GLY GLN THR
SEQRES 2 e 56 PRO LYS VAL ALA LYS GLN GLU LYS LYS LYS LYS LYS THR
SEQRES 3 e 56 GLY ARG ALA LYS ARG ARG MET GLN TYR ASN ARG ARG PHE
SEQRES 4 e 56 VAL ASN VAL VAL PRO THR PHE GLY LYS LYS LYS GLY PRO
SEQRES 5 e 56 ASN ALA ASN SER
SEQRES 1 f 72 LYS LYS ARG LYS LYS LYS SER CYS THR THR PRO LYS LYS
SEQRES 2 f 72 ASN LYS HIS LYS ARG LYS LYS VAL LYS LEU ALA VAL LEU
SEQRES 3 f 72 LYS TYR TYR LYS VAL ASP GLU ASN GLY LYS ILE SER ARG
SEQRES 4 f 72 LEU ARG ARG GLU CYS PRO SER ASP GLU CYS GLY ALA GLY
SEQRES 5 f 72 VAL PHE MET ALA SER HIS PHE ASP ARG HIS TYR CYS GLY
SEQRES 6 f 72 LYS CYS CYS LEU THR TYR CYS
SEQRES 1 g 315 MET THR GLU GLN MET THR LEU ARG GLY THR LEU LYS GLY
SEQRES 2 g 315 HIS ASN GLY TRP VAL THR GLN ILE ALA THR THR PRO GLN
SEQRES 3 g 315 PHE PRO ASP MET ILE LEU SER ALA SER ARG ASP LYS THR
SEQRES 4 g 315 ILE ILE MET TRP LYS LEU THR ARG ASP GLU THR ASN TYR
SEQRES 5 g 315 GLY ILE PRO GLN ARG ALA LEU ARG GLY HIS SER HIS PHE
SEQRES 6 g 315 VAL SER ASP VAL VAL ILE SER SER ASP GLY GLN PHE ALA
SEQRES 7 g 315 LEU SER GLY SER TRP ASP GLY THR LEU ARG LEU TRP ASP
SEQRES 8 g 315 LEU THR THR GLY THR THR THR ARG ARG PHE VAL GLY HIS
SEQRES 9 g 315 THR LYS ASP VAL LEU SER VAL ALA PHE SER SER ASP ASN
SEQRES 10 g 315 ARG GLN ILE VAL SER GLY SER ARG ASP LYS THR ILE LYS
SEQRES 11 g 315 LEU TRP ASN THR LEU GLY VAL CYS LYS TYR THR VAL GLN
SEQRES 12 g 315 ASP GLU SER HIS SER GLU TRP VAL SER CYS VAL ARG PHE
SEQRES 13 g 315 SER PRO ASN SER SER ASN PRO ILE ILE VAL SER CYS GLY
SEQRES 14 g 315 TRP ASP LYS LEU VAL LYS VAL TRP ASN LEU ALA ASN CYS
SEQRES 15 g 315 LYS LEU LYS THR ASN HIS ILE GLY HIS THR GLY TYR LEU
SEQRES 16 g 315 ASN THR VAL THR VAL SER PRO ASP GLY SER LEU CYS ALA
SEQRES 17 g 315 SER GLY GLY LYS ASP GLY GLN ALA MET LEU TRP ASP LEU
SEQRES 18 g 315 ASN GLU GLY LYS HIS LEU TYR THR LEU ASP GLY GLY ASP
SEQRES 19 g 315 ILE ILE ASN ALA LEU CYS PHE SER PRO ASN ARG TYR TRP
SEQRES 20 g 315 LEU CYS ALA ALA THR GLY PRO SER ILE LYS ILE TRP ASP
SEQRES 21 g 315 LEU GLU GLY LYS ILE ILE VAL ASP GLU LEU LYS GLN GLU
SEQRES 22 g 315 VAL ILE SER THR SER SER LYS ALA GLU PRO PRO GLN CYS
SEQRES 23 g 315 THR SER LEU ALA TRP SER ALA ASP GLY GLN THR LEU PHE
SEQRES 24 g 315 ALA GLY TYR THR ASP ASN LEU VAL ARG VAL TRP GLN VAL
SEQRES 25 g 315 THR ILE GLY
SEQRES 1 h 24 ARG ALA LYS TRP ARG LYS LYS ARG MET ARG ARG LEU LYS
SEQRES 2 h 24 ARG LYS ARG ARG LYS MET ARG GLN ARG SER LYS
HET ZN a 201 1
HET ZN d 201 1
HET ZN f 500 1
HETNAM ZN ZINC ION
FORMUL 39 ZN 3(ZN 2+)
HELIX 1 AA1 LYS 0 15 PHE 0 30 1 16
HELIX 2 AA2 THR 0 32 VAL 0 42 1 11
HELIX 3 AA3 THR 0 82 TYR 0 89 1 8
HELIX 4 AA4 PRO 0 90 LEU 0 93 5 4
HELIX 5 AA5 TRP 0 99 VAL 0 107 1 9
HELIX 6 AA6 LEU 0 114 MET 0 119 1 6
HELIX 7 AA7 SER 0 152 GLY 0 160 1 9
HELIX 8 AA8 ASP 0 174 GLY 0 180 1 7
HELIX 9 AA9 GLN 0 261 CYS 0 278 1 18
HELIX 10 AB1 THR 0 289 GLY 0 294 1 6
HELIX 11 AB2 ASP 0 308 SER 0 312 5 5
HELIX 12 AB3 LYS 0 316 MET 0 324 1 9
HELIX 13 AB4 PRO 0 388 SER 0 390 5 3
HELIX 14 AB5 MET 0 391 GLN 0 396 1 6
HELIX 15 AB6 GLU 0 407 ASN 0 422 1 16
HELIX 16 AB7 ASP 0 436 ILE 0 443 1 8
HELIX 17 AB8 TRP 0 457 LEU 0 468 1 12
HELIX 18 AB9 LEU 0 510 GLY 0 514 5 5
HELIX 19 AC1 ASP 0 516 GLN 0 529 1 14
HELIX 20 AC2 GLN 0 552 GLU 0 562 1 11
HELIX 21 AC3 PRO 0 567 LYS 0 569 5 3
HELIX 22 AC4 LYS A 11 GLY A 22 1 12
HELIX 23 AC5 GLN A 33 GLN A 36 5 4
HELIX 24 AC6 ASN A 50 ALA A 67 1 18
HELIX 25 AC7 ASN A 70 ALA A 72 5 3
HELIX 26 AC8 ARG A 80 THR A 82 5 3
HELIX 27 AC9 GLY A 83 GLY A 95 1 13
HELIX 28 AD1 HIS A 131 ASN A 141 1 11
HELIX 29 AD2 GLY A 167 GLY A 187 1 21
HELIX 30 AD3 MET A 198 PHE A 203 5 6
HELIX 31 AD4 ASP A 206 GLN A 215 1 10
HELIX 32 AD5 ASP B 23 SER B 26 5 4
HELIX 33 AD6 ILE B 57 LEU B 62 1 6
HELIX 34 AD7 LEU B 71 GLN B 75 1 5
HELIX 35 AD8 THR B 106 VAL B 114 1 9
HELIX 36 AD9 GLN B 157 THR B 178 1 22
HELIX 37 AE1 ASP B 180 ILE B 189 1 10
HELIX 38 AE2 ASP B 191 CYS B 201 1 11
HELIX 39 AE3 GLU B 224 GLY B 233 1 10
HELIX 40 AE4 THR C 64 ASP C 72 1 9
HELIX 41 AE5 LEU C 78 SER C 85 1 8
HELIX 42 AE6 GLU C 90 LEU C 98 1 9
HELIX 43 AE7 GLU C 146 SER C 161 1 16
HELIX 44 AE8 ALA C 207 ALA C 217 1 11
HELIX 45 AE9 THR C 232 THR C 247 1 16
HELIX 46 AF1 TYR C 248 TYR C 250 5 3
HELIX 47 AF2 THR C 252 LYS C 257 5 6
HELIX 48 AF3 SER C 264 PHE C 269 1 6
HELIX 49 AF4 PHE C 269 LYS C 275 1 7
HELIX 50 AF5 SER D 6 LEU D 29 1 24
HELIX 51 AF6 ALA D 30 ASP D 32 5 3
HELIX 52 AF7 ARG D 54 GLY D 60 1 7
HELIX 53 AF8 GLY D 63 GLY D 78 1 16
HELIX 54 AF9 CYS D 97 GLY D 111 1 15
HELIX 55 AG1 ALA D 114 SER D 129 1 16
HELIX 56 AG2 PRO D 163 TYR D 167 1 5
HELIX 57 AG3 PRO E 15 MET E 19 5 5
HELIX 58 AG4 LEU E 44 ASN E 50 1 7
HELIX 59 AG5 THR E 57 MET E 66 1 10
HELIX 60 AG6 GLU E 117 ALA E 119 5 3
HELIX 61 AG7 THR E 247 SER E 261 1 15
HELIX 62 AG8 LYS F 18 LYS F 22 5 5
HELIX 63 AG9 PRO F 67 SER F 75 1 9
HELIX 64 AH1 HIS F 79 ASN F 83 5 5
HELIX 65 AH2 LYS F 86 THR F 104 1 19
HELIX 66 AH3 ASN F 107 GLY F 120 1 14
HELIX 67 AH4 SER F 142 PHE F 163 1 22
HELIX 68 AH5 THR F 168 GLY F 183 1 16
HELIX 69 AH6 SER F 187 ARG F 204 1 18
HELIX 70 AH7 ASP G 20 THR G 26 1 7
HELIX 71 AH8 ARG G 137 ASN G 146 1 10
HELIX 72 AH9 ASP G 152 VAL G 157 1 6
HELIX 73 AI1 THR G 181 ALA G 229 1 49
HELIX 74 AI2 ASP H 17 ASN H 33 1 17
HELIX 75 AI3 LEU H 36 LEU H 43 1 8
HELIX 76 AI4 PRO H 65 PRO H 67 5 3
HELIX 77 AI5 GLN H 68 SER H 88 1 21
HELIX 78 AI6 THR H 121 VAL H 134 1 14
HELIX 79 AI7 GLN H 162 GLU H 167 1 6
HELIX 80 AI8 VAL H 170 THR H 181 1 12
HELIX 81 AI9 ARG I 25 TYR I 27 5 3
HELIX 82 AJ1 ARG I 49 GLY I 51 5 3
HELIX 83 AJ2 ASN I 88 THR I 93 1 6
HELIX 84 AJ3 SER I 106 TYR I 117 1 12
HELIX 85 AJ4 THR I 130 ASN I 138 1 9
HELIX 86 AJ5 SER I 142 LYS I 154 1 13
HELIX 87 AJ6 SER I 159 GLY I 169 1 11
HELIX 88 AJ7 ARG I 178 GLY I 183 1 6
HELIX 89 AJ8 GLU I 191 ALA I 204 1 14
HELIX 90 AJ9 GLU J 21 GLY J 36 1 16
HELIX 91 AK1 ASN J 39 THR J 62 1 24
HELIX 92 AK2 ASP J 67 ILE J 84 1 18
HELIX 93 AK3 LEU J 94 LEU J 100 5 7
HELIX 94 AK4 LYS J 101 ARG J 108 1 8
HELIX 95 AK5 ARG J 109 LEU J 117 1 9
HELIX 96 AK6 SER J 122 GLN J 132 1 11
HELIX 97 AK7 LEU J 151 LYS J 155 5 5
HELIX 98 AK8 SER J 163 GLY J 168 1 6
HELIX 99 AK9 GLY J 171 GLY J 181 1 11
HELIX 100 AL1 PRO K 4 GLY K 19 1 16
HELIX 101 AL2 PRO K 41 ALA K 48 1 8
HELIX 102 AL3 ALA K 48 GLY K 56 1 9
HELIX 103 AL4 THR K 72 LEU K 83 1 12
HELIX 104 AL5 PRO K 91 ARG K 95 5 5
HELIX 105 AL6 VAL L 23 THR L 28 1 6
HELIX 106 AL7 PRO L 47 GLY L 53 1 7
HELIX 107 AL8 ALA M 17 HIS M 28 1 12
HELIX 108 AL9 GLY M 34 ASP M 43 1 10
HELIX 109 AM1 PRO M 59 HIS M 72 1 14
HELIX 110 AM2 ASP M 81 GLY M 90 1 10
HELIX 111 AM3 GLN M 119 LYS M 132 1 14
HELIX 112 AM4 THR N 29 LYS N 42 1 14
HELIX 113 AM5 THR N 46 HIS N 58 1 13
HELIX 114 AM6 GLN N 62 GLY N 68 1 7
HELIX 115 AM7 LYS N 70 GLY N 79 1 10
HELIX 116 AM8 PRO N 85 ASN N 105 1 21
HELIX 117 AM9 ASP N 108 LYS N 132 1 25
HELIX 118 AN1 THR N 145 VAL N 150 1 6
HELIX 119 AN2 GLY O 58 VAL O 62 1 5
HELIX 120 AN3 SER O 70 LEU O 88 1 19
HELIX 121 AN4 PRO O 110 SER O 122 1 13
HELIX 122 AN5 ASP P 21 MET P 28 1 8
HELIX 123 AN6 SER P 29 TYR P 37 1 9
HELIX 124 AN7 SER P 38 ASN P 46 1 9
HELIX 125 AN8 ARG P 50 GLU P 66 1 17
HELIX 126 AN9 LEU P 86 VAL P 90 5 5
HELIX 127 AO1 PRO Q 38 ILE Q 42 5 5
HELIX 128 AO2 LEU Q 47 LEU Q 52 1 6
HELIX 129 AO3 LEU Q 52 GLY Q 59 1 8
HELIX 130 AO4 GLY Q 76 TYR Q 99 1 24
HELIX 131 AO5 ASP Q 101 GLN Q 114 1 14
HELIX 132 AO6 THR R 6 TYR R 21 1 16
HELIX 133 AO7 ASP R 27 ILE R 38 1 12
HELIX 134 AO8 LYS R 44 GLN R 62 1 19
HELIX 135 AO9 GLN R 74 ASN R 83 1 10
HELIX 136 AP1 ASP R 99 LEU R 109 1 11
HELIX 137 AP2 ILE S 26 THR S 31 1 6
HELIX 138 AP3 GLY S 37 ALA S 48 1 12
HELIX 139 AP4 THR S 60 ASN S 73 1 14
HELIX 140 AP5 PRO S 80 LEU S 84 5 5
HELIX 141 AP6 LEU S 99 ARG S 118 1 20
HELIX 142 AP7 ALA S 119 GLY S 128 1 10
HELIX 143 AP8 THR T 5 VAL T 9 5 5
HELIX 144 AP9 ASN T 10 GLY T 26 1 17
HELIX 145 AQ1 ASN T 51 ARG T 67 1 17
HELIX 146 AQ2 GLY T 71 TYR T 79 1 9
HELIX 147 AQ3 SER T 96 LEU T 110 1 15
HELIX 148 AQ4 THR T 124 HIS T 145 1 22
HELIX 149 AQ5 ASN U 28 GLU U 45 1 18
HELIX 150 AQ6 PRO U 94 SER U 105 1 12
HELIX 151 AQ7 CYS V 56 MET V 62 1 7
HELIX 152 AQ8 GLU V 64 GLY V 77 1 14
HELIX 153 AQ9 ASN W 5 GLY W 21 1 17
HELIX 154 AR1 SER W 31 GLY W 45 1 15
HELIX 155 AR2 ASP W 85 LEU W 94 1 10
HELIX 156 AR3 HIS W 113 HIS W 120 1 8
HELIX 157 AR4 THR X 9 TRP X 22 1 14
HELIX 158 AR5 ASP X 24 GLY X 33 1 10
HELIX 159 AR6 GLY X 33 ASN X 39 1 7
HELIX 160 AR7 GLY X 89 PHE X 93 5 5
HELIX 161 AR8 LEU X 130 GLY X 136 1 7
HELIX 162 AR9 PRO Y 36 LYS Y 49 1 14
HELIX 163 AS1 THR Y 51 ASP Y 53 5 3
HELIX 164 AS2 SER Y 78 GLU Y 86 1 9
HELIX 165 AS3 PRO Y 87 ARG Y 93 1 7
HELIX 166 AS4 SER Y 103 LYS Y 115 1 13
HELIX 167 AS5 THR Y 120 VAL Y 125 5 6
HELIX 168 AS6 ASP Z 51 GLU Z 61 1 11
HELIX 169 AS7 VAL Z 62 TYR Z 65 5 4
HELIX 170 AS8 THR Z 69 LEU Z 77 1 9
HELIX 171 AS9 ARG Z 80 LYS Z 94 1 15
HELIX 172 AT1 GLU a 46 SER a 54 1 9
HELIX 173 AT2 CYS a 74 LYS a 82 1 9
HELIX 174 AT3 SER a 88 LYS a 93 1 6
HELIX 175 AT4 SER b 11 LYS b 18 1 8
HELIX 176 AT5 ARG d 40 GLY d 51 1 12
HELIX 177 AT6 GLY e 10 GLN e 15 1 6
HELIX 178 AT7 THR e 29 ARG e 40 1 12
HELIX 179 AT8 LEU f 100 LYS f 104 5 5
HELIX 180 AT9 ALA h 3 ARG h 21 1 19
SHEET 1 AA1 5 ARG 0 7 ALA 0 13 0
SHEET 2 AA1 5 ASN 0 49 TYR 0 54 -1 O LYS 0 52 N SER 0 10
SHEET 3 AA1 5 ALA 0 60 SER 0 66 -1 O VAL 0 65 N ASN 0 49
SHEET 4 AA1 5 ASN 0 69 GLU 0 74 -1 O ILE 0 71 N TYR 0 64
SHEET 5 AA1 5 TYR 0 80 PRO 0 81 -1 O TYR 0 80 N PHE 0 73
SHEET 1 AA2 5 THR 0 95 THR 0 98 0
SHEET 2 AA2 5 LEU 0 132 LEU 0 137 1 O SER 0 136 N PHE 0 96
SHEET 3 AA2 5 ALA 0 145 ALA 0 149 -1 O GLY 0 147 N CYS 0 133
SHEET 4 AA2 5 ARG 0 164 THR 0 171 -1 O HIS 0 170 N ILE 0 146
SHEET 5 AA2 5 LEU 0 112 MET 0 113 -1 N LEU 0 112 O PHE 0 166
SHEET 1 AA3 3 PRO 0 286 LEU 0 288 0
SHEET 2 AA3 3 GLU 0 340 ALA 0 344 -1 O ILE 0 342 N LEU 0 287
SHEET 3 AA3 3 ILE 0 330 GLU 0 334 -1 N GLN 0 331 O VAL 0 343
SHEET 1 AA4 2 MET 0 297 PHE 0 298 0
SHEET 2 AA4 2 CYS 0 301 PRO 0 302 -1 O CYS 0 301 N PHE 0 298
SHEET 1 AA5 4 PHE 0 405 LEU 0 406 0
SHEET 2 AA5 4 ASP 0 380 CYS 0 386 -1 N TYR 0 385 O LEU 0 406
SHEET 3 AA5 4 GLN 0 469 THR 0 475 -1 O GLN 0 473 N LYS 0 382
SHEET 4 AA5 4 ILE 0 482 LYS 0 485 -1 O LYS 0 484 N TYR 0 472
SHEET 1 AA6 2 LEU 0 432 ARG 0 434 0
SHEET 2 AA6 2 LYS 0 454 PRO 0 456 -1 O LEU 0 455 N VAL 0 433
SHEET 1 AA7 5 THR 0 532 PRO 0 536 0
SHEET 2 AA7 5 LEU 0 544 GLN 0 549 -1 O GLN 0 545 N ASN 0 535
SHEET 3 AA7 5 LYS 0 502 ARG 0 508 -1 N THR 0 505 O ILE 0 548
SHEET 4 AA7 5 ILE 0 491 ARG 0 498 -1 N THR 0 494 O VAL 0 506
SHEET 5 AA7 5 ILE 0 571 GLN 0 572 1 O GLN 0 572 N ILE 0 491
SHEET 1 AA8 2 ILE A 38 ARG A 41 0
SHEET 2 AA8 2 TYR A 47 ILE A 49 -1 O ILE A 48 N TYR A 39
SHEET 1 AA9 5 THR A 97 ALA A 100 0
SHEET 2 AA9 5 VAL A 74 SER A 78 1 N VAL A 76 O ILE A 99
SHEET 3 AA9 5 LEU A 121 VAL A 124 1 O VAL A 123 N ILE A 77
SHEET 4 AA9 5 THR A 144 CYS A 148 1 O ILE A 145 N LEU A 122
SHEET 5 AA9 5 ILE A 159 PRO A 162 1 O ILE A 161 N ALA A 146
SHEET 1 AB1 5 ASN B 43 THR B 50 0
SHEET 2 AB1 5 LYS B 28 LYS B 34 -1 N ASP B 29 O VAL B 49
SHEET 3 AB1 5 CYS B 96 LEU B 105 1 O CYS B 96 N ASP B 32
SHEET 4 AB1 5 ARG B 82 VAL B 91 -1 N ILE B 87 O ASN B 99
SHEET 5 AB1 5 VAL B 66 SER B 70 -1 N VAL B 69 O PHE B 84
SHEET 1 AB2 6 ASN B 43 THR B 50 0
SHEET 2 AB2 6 LYS B 28 LYS B 34 -1 N ASP B 29 O VAL B 49
SHEET 3 AB2 6 CYS B 96 LEU B 105 1 O CYS B 96 N ASP B 32
SHEET 4 AB2 6 PHE B 211 MET B 217 -1 O VAL B 215 N MET B 103
SHEET 5 AB2 6 LEU B 134 PHE B 142 -1 N PHE B 138 O LYS B 214
SHEET 6 AB2 6 MET B 120 LYS B 128 -1 N VAL B 125 O LEU B 137
SHEET 1 AB3 4 LEU C 102 THR C 116 0
SHEET 2 AB3 4 GLY C 119 ASP C 132 -1 O ALA C 129 N GLU C 105
SHEET 3 AB3 4 HIS C 136 SER C 144 -1 O GLY C 140 N VAL C 128
SHEET 4 AB3 4 ILE C 162 PRO C 164 -1 O VAL C 163 N VAL C 137
SHEET 1 AB4 4 VAL C 184 CYS C 188 0
SHEET 2 AB4 4 VAL C 191 PRO C 197 -1 O VAL C 191 N CYS C 188
SHEET 3 AB4 4 CYS C 222 ARG C 227 -1 O ARG C 227 N LEU C 192
SHEET 4 AB4 4 ILE C 204 VAL C 205 1 N VAL C 205 O CYS C 222
SHEET 1 AB5 3 TYR D 34 VAL D 41 0
SHEET 2 AB5 3 THR D 46 ALA D 52 -1 O LEU D 51 N GLY D 36
SHEET 3 AB5 3 VAL D 84 LYS D 90 1 O GLU D 89 N ILE D 50
SHEET 1 AB6 4 LYS D 148 GLY D 155 0
SHEET 2 AB6 4 GLY D 133 GLY D 140 -1 N CYS D 134 O ASP D 154
SHEET 3 AB6 4 GLY D 180 MET D 189 -1 O LYS D 185 N VAL D 137
SHEET 4 AB6 4 VAL D 168 LEU D 177 -1 N LEU D 177 O GLY D 180
SHEET 1 AB7 2 SER D 209 ILE D 210 0
SHEET 2 AB7 2 ALA R 39 ILE R 40 -1 O ILE R 40 N SER D 209
SHEET 1 AB8 5 ILE D 223 GLN D 226 0
SHEET 2 AB8 5 LYS g 183 ILE g 189 -1 O ASN g 187 N GLU D 225
SHEET 3 AB8 5 LEU g 173 ASN g 178 -1 N VAL g 174 O HIS g 188
SHEET 4 AB8 5 ILE g 164 GLY g 169 -1 N GLY g 169 O LEU g 173
SHEET 5 AB8 5 VAL g 151 PHE g 156 -1 N ARG g 155 O VAL g 166
SHEET 1 AB9 2 LEU E 42 PRO E 43 0
SHEET 2 AB9 2 PRO E 83 ALA E 84 -1 O ALA E 84 N LEU E 42
SHEET 1 AC1 5 LYS E 75 VAL E 76 0
SHEET 2 AC1 5 ILE E 70 ILE E 72 -1 N ILE E 72 O LYS E 75
SHEET 3 AC1 5 ASP E 88 ILE E 92 -1 O SER E 91 N LYS E 71
SHEET 4 AC1 5 GLU E 97 TYR E 103 -1 O PHE E 99 N ILE E 90
SHEET 5 AC1 5 PHE E 109 ALA E 110 -1 O ALA E 110 N ILE E 102
SHEET 1 AC2 3 TYR E 121 LYS E 125 0
SHEET 2 AC2 3 THR E 159 ASP E 163 -1 O ILE E 162 N LYS E 122
SHEET 3 AC2 3 ILE E 169 ILE E 173 -1 O THR E 170 N GLN E 161
SHEET 1 AC3 3 LYS E 128 GLY E 132 0
SHEET 2 AC3 3 ILE E 136 VAL E 140 -1 O ILE E 136 N GLY E 132
SHEET 3 AC3 3 THR E 146 ARG E 148 -1 O ILE E 147 N LEU E 139
SHEET 1 AC4 6 SER E 217 ARG E 221 0
SHEET 2 AC4 6 VAL E 207 LYS E 211 -1 N VAL E 208 O THR E 220
SHEET 3 AC4 6 ILE E 192 GLU E 199 -1 N ASN E 197 O HIS E 209
SHEET 4 AC4 6 LEU E 180 VAL E 183 -1 N CYS E 181 O GLY E 193
SHEET 5 AC4 6 ILE E 225 LYS E 230 -1 O GLY E 229 N LEU E 180
SHEET 6 AC4 6 LYS E 233 PRO E 234 -1 O LYS E 233 N LYS E 230
SHEET 1 AC5 6 GLU F 123 ILE F 128 0
SHEET 2 AC5 6 ARG F 135 VAL F 141 -1 O VAL F 139 N ASP F 124
SHEET 3 AC5 6 SER c 41 LYS c 47 1 O LYS c 47 N ASP F 140
SHEET 4 AC5 6 THR c 28 PHE c 34 -1 N VAL c 30 O ARG c 44
SHEET 5 AC5 6 LYS c 10 GLY c 19 -1 N ARG c 13 O GLU c 33
SHEET 6 AC5 6 VAL c 55 LEU c 58 -1 O LEU c 58 N LYS c 10
SHEET 1 AC6 5 CYS G 12 GLU G 17 0
SHEET 2 AC6 5 LYS G 2 PHE G 7 -1 N LEU G 3 O ILE G 16
SHEET 3 AC6 5 LEU G 106 LYS G 115 1 O LEU G 111 N SER G 6
SHEET 4 AC6 5 VAL G 49 ASP G 57 -1 N ARG G 51 O VAL G 112
SHEET 5 AC6 5 GLU G 35 ALA G 37 -1 N VAL G 36 O VAL G 50
SHEET 1 AC7 2 ARG G 72 LEU G 77 0
SHEET 2 AC7 2 LYS G 93 ARG G 98 -1 O LYS G 93 N LEU G 77
SHEET 1 AC8 2 LYS G 160 LYS G 164 0
SHEET 2 AC8 2 LYS G 167 LYS G 172 -1 O ARG G 170 N LEU G 162
SHEET 1 AC9 3 ALA H 47 VAL H 53 0
SHEET 2 AC9 3 ARG H 57 VAL H 64 -1 O ARG H 57 N VAL H 53
SHEET 3 AC9 3 HIS H 91 ALA H 96 1 O HIS H 91 N ILE H 60
SHEET 1 AD1 6 VAL H 185 GLU H 188 0
SHEET 2 AD1 6 ARG H 152 LEU H 158 1 N VAL H 156 O GLU H 188
SHEET 3 AD1 6 ILE H 139 VAL H 146 -1 N ARG H 143 O LYS H 155
SHEET 4 AD1 6 PHE W 50 ASP W 54 -1 O ILE W 52 N ILE H 144
SHEET 5 AD1 6 LYS W 60 ASN W 64 -1 O VAL W 62 N GLU W 51
SHEET 6 AD1 6 GLN W 24 ILE W 27 -1 N ILE W 27 O ILE W 61
SHEET 1 AD2 2 ILE I 3 SER I 4 0
SHEET 2 AD2 2 LEU I 29 GLY I 30 -1 O GLY I 30 N ILE I 3
SHEET 1 AD3 3 LYS I 37 ILE I 38 0
SHEET 2 AD3 3 LYS I 53 LEU I 60 1 O LEU I 58 N LYS I 37
SHEET 3 AD3 3 ARG I 42 ARG I 47 -1 N HIS I 44 O ARG I 56
SHEET 1 AD4 6 VAL I 62 TRP I 67 0
SHEET 2 AD4 6 CYS I 72 TYR I 83 -1 O THR I 76 N GLY I 63
SHEET 3 AD4 6 ILE I 101 ASP I 105 -1 O ILE I 101 N TYR I 83
SHEET 4 AD4 6 LYS I 170 ILE I 175 -1 O ALA I 173 N VAL I 102
SHEET 5 AD4 6 GLY I 187 VAL I 189 -1 O TYR I 188 N CYS I 174
SHEET 6 AD4 6 VAL I 62 TRP I 67 1 N SER I 66 O VAL I 189
SHEET 1 AD5 3 GLN J 140 VAL J 141 0
SHEET 2 AD5 3 ARG J 136 VAL J 137 -1 N VAL J 137 O GLN J 140
SHEET 3 AD5 3 ILE J 157 ASP J 158 -1 O ASP J 158 N ARG J 136
SHEET 1 AD6 3 VAL K 20 ALA K 23 0
SHEET 2 AD6 3 PHE K 67 LEU K 71 -1 O PHE K 67 N ALA K 23
SHEET 3 AD6 3 VAL K 58 PHE K 62 -1 N GLN K 61 O TYR K 68
SHEET 1 AD7 6 ILE L 72 LYS L 79 0
SHEET 2 AD7 6 THR L 85 ILE L 96 -1 O VAL L 87 N THR L 78
SHEET 3 AD7 6 ARG L 101 HIS L 112 -1 O ARG L 105 N TYR L 92
SHEET 4 AD7 6 PHE L 140 THR L 146 1 O PHE L 140 N HIS L 112
SHEET 5 AD7 6 ILE L 125 GLU L 130 -1 N ILE L 125 O THR L 146
SHEET 6 AD7 6 ILE L 72 LYS L 79 -1 N LEU L 73 O VAL L 128
SHEET 1 AD8 4 LEU M 31 ARG M 33 0
SHEET 2 AD8 4 CYS M 108 VAL M 111 -1 O VAL M 110 N ALA M 32
SHEET 3 AD8 4 LEU M 49 ALA M 53 -1 N LEU M 49 O VAL M 111
SHEET 4 AD8 4 LEU M 76 VAL M 79 1 O ILE M 77 N LEU M 52
SHEET 1 AD9 5 THR O 52 THR O 57 0
SHEET 2 AD9 5 THR O 40 THR O 45 -1 N VAL O 42 O VAL O 56
SHEET 3 AD9 5 PHE O 28 ALA O 35 -1 N HIS O 32 O HIS O 43
SHEET 4 AD9 5 ALA O 92 ARG O 98 1 O HIS O 94 N CYS O 31
SHEET 5 AD9 5 LYS O 125 ASP O 131 1 O GLY O 127 N LEU O 93
SHEET 1 AE1 3 VAL P 76 THR P 78 0
SHEET 2 AE1 3 MET P 93 TYR P 97 1 O GLY P 95 N VAL P 76
SHEET 3 AE1 3 PHE P 102 GLU P 106 -1 O VAL P 105 N VAL P 94
SHEET 1 AE2 4 VAL Q 10 LYS Q 16 0
SHEET 2 AE2 4 ALA Q 19 LYS Q 26 -1 O CYS Q 25 N VAL Q 10
SHEET 3 AE2 4 ASP Q 67 LYS Q 73 -1 O LYS Q 73 N THR Q 20
SHEET 4 AE2 4 ILE Q 32 VAL Q 34 1 N LYS Q 33 O VAL Q 70
SHEET 1 AE3 2 ILE R 96 VAL R 98 0
SHEET 2 AE3 2 LEU R 117 VAL R 119 1 O GLN R 118 N VAL R 98
SHEET 1 AE4 2 ILE S 12 VAL S 15 0
SHEET 2 AE4 2 THR S 18 ASP S 21 -1 O THR S 18 N VAL S 15
SHEET 1 AE5 2 GLY T 81 ARG T 84 0
SHEET 2 AE5 2 SER T 90 SER T 93 -1 O SER T 93 N GLY T 81
SHEET 1 AE6 2 VAL T 113 LYS T 115 0
SHEET 2 AE6 2 ARG T 121 LEU T 123 -1 O LYS T 122 N GLU T 114
SHEET 1 AE7 3 LYS U 49 ARG U 55 0
SHEET 2 AE7 3 TRP U 77 HIS U 92 -1 O ASP U 90 N LYS U 51
SHEET 3 AE7 3 LYS U 59 ARG U 66 -1 N LYS U 59 O ILE U 84
SHEET 1 AE8 4 LYS U 49 ARG U 55 0
SHEET 2 AE8 4 TRP U 77 HIS U 92 -1 O ASP U 90 N LYS U 51
SHEET 3 AE8 4 ILE U 20 SER U 26 -1 N SER U 26 O HIS U 85
SHEET 4 AE8 4 VAL U 110 ILE U 116 -1 O GLU U 113 N THR U 23
SHEET 1 AE9 2 ILE V 32 VAL V 39 0
SHEET 2 AE9 2 PHE V 46 ILE V 55 -1 O TYR V 53 N MET V 34
SHEET 1 AF1 3 LYS W 71 VAL W 74 0
SHEET 2 AF1 3 GLY W 123 PHE W 130 -1 O PHE W 128 N GLY W 73
SHEET 3 AF1 3 ASP W 80 VAL W 81 -1 N VAL W 81 O GLY W 123
SHEET 1 AF2 4 LYS W 71 VAL W 74 0
SHEET 2 AF2 4 GLY W 123 PHE W 130 -1 O PHE W 128 N GLY W 73
SHEET 3 AF2 4 PHE W 101 THR W 105 -1 N VAL W 103 O GLY W 127
SHEET 4 AF2 4 ILE W 110 ASP W 112 -1 O MET W 111 N LEU W 104
SHEET 1 AF3 7 VAL X 128 SER X 129 0
SHEET 2 AF3 7 PHE X 120 VAL X 125 -1 N VAL X 125 O VAL X 128
SHEET 3 AF3 7 GLU X 99 GLY X 104 -1 N ALA X 103 O LYS X 121
SHEET 4 AF3 7 HIS X 46 GLU X 58 -1 N GLY X 49 O VAL X 100
SHEET 5 AF3 7 ILE X 66 LEU X 74 -1 O ARG X 67 N VAL X 57
SHEET 6 AF3 7 LYS X 80 PHE X 84 -1 O ALA X 83 N VAL X 70
SHEET 7 AF3 7 PHE X 120 VAL X 125 1 O VAL X 122 N PHE X 84
SHEET 1 AF4 4 THR Y 6 ASN Y 15 0
SHEET 2 AF4 4 ARG Y 20 LEU Y 28 -1 O ASP Y 26 N ARG Y 8
SHEET 3 AF4 4 LYS Y 68 TYR Y 76 -1 O GLY Y 73 N MET Y 23
SHEET 4 AF4 4 ILE Y 55 THR Y 62 -1 N PHE Y 58 O PHE Y 72
SHEET 1 AF5 3 LEU Z 67 ILE Z 68 0
SHEET 2 AF5 3 GLN Z 106 ARG Z 111 -1 O TYR Z 109 N ILE Z 68
SHEET 3 AF5 3 ILE Z 97 HIS Z 103 -1 N HIS Z 103 O GLN Z 106
SHEET 1 AF6 2 PRO a 20 ARG a 22 0
SHEET 2 AF6 2 CYS a 29 PRO a 31 -1 O VAL a 30 N ILE a 21
SHEET 1 AF7 2 ILE a 36 ASN a 43 0
SHEET 2 AF7 2 LYS a 66 TYR a 73 -1 O TYR a 73 N ILE a 36
SHEET 1 AF8 3 ILE b 43 PHE b 47 0
SHEET 2 AF8 3 PHE b 32 LYS b 36 -1 N MET b 33 O VAL b 46
SHEET 3 AF8 3 SER b 78 ARG b 81 -1 O SER b 78 N LYS b 36
SHEET 1 AF9 3 VAL b 54 CYS b 56 0
SHEET 2 AF9 3 THR b 61 GLN b 65 -1 O THR b 61 N CYS b 56
SHEET 3 AF9 3 ARG b 72 LEU b 73 -1 O ARG b 72 N GLN b 65
SHEET 1 AG1 2 LEU d 30 ILE d 31 0
SHEET 2 AG1 2 MET d 38 CYS d 39 -1 O MET d 38 N ILE d 31
SHEET 1 AG2 2 TYR f 106 VAL f 108 0
SHEET 2 AG2 2 ILE f 114 ARG f 116 -1 O SER f 115 N LYS f 107
SHEET 1 AG3 3 SER f 134 HIS f 135 0
SHEET 2 AG3 3 ARG f 138 TYR f 140 -1 O ARG f 138 N HIS f 135
SHEET 3 AG3 3 THR f 147 TYR f 148 -1 O TYR f 148 N HIS f 139
SHEET 1 AG4 4 GLU g 3 LEU g 11 0
SHEET 2 AG4 4 VAL g 307 ILE g 314 -1 O VAL g 307 N LEU g 11
SHEET 3 AG4 4 THR g 297 TYR g 302 -1 N ALA g 300 O ARG g 308
SHEET 4 AG4 4 CYS g 286 TRP g 291 -1 N ALA g 290 O PHE g 299
SHEET 1 AG5 4 VAL g 18 ALA g 22 0
SHEET 2 AG5 4 MET g 30 SER g 35 -1 O LEU g 32 N ALA g 22
SHEET 3 AG5 4 ILE g 40 LYS g 44 -1 O ILE g 41 N SER g 33
SHEET 4 AG5 4 ILE g 54 LEU g 59 -1 O ILE g 54 N LYS g 44
SHEET 1 AG6 4 VAL g 66 ILE g 71 0
SHEET 2 AG6 4 PHE g 77 SER g 82 -1 O GLY g 81 N ASP g 68
SHEET 3 AG6 4 THR g 86 ASP g 91 -1 O ARG g 88 N SER g 80
SHEET 4 AG6 4 THR g 96 PHE g 101 -1 O PHE g 101 N LEU g 87
SHEET 1 AG7 4 VAL g 108 PHE g 113 0
SHEET 2 AG7 4 ILE g 120 SER g 124 -1 O GLY g 123 N SER g 110
SHEET 3 AG7 4 ILE g 129 TRP g 132 -1 O LYS g 130 N SER g 122
SHEET 4 AG7 4 CYS g 138 VAL g 142 -1 O LYS g 139 N LEU g 131
SHEET 1 AG8 4 LEU g 195 VAL g 200 0
SHEET 2 AG8 4 LEU g 206 GLY g 211 -1 O ALA g 208 N THR g 199
SHEET 3 AG8 4 ALA g 216 ASP g 220 -1 O TRP g 219 N CYS g 207
SHEET 4 AG8 4 LYS g 225 LEU g 230 -1 O LEU g 230 N ALA g 216
SHEET 1 AG9 4 ILE g 236 PHE g 241 0
SHEET 2 AG9 4 TRP g 247 THR g 252 -1 O ALA g 251 N ASN g 237
SHEET 3 AG9 4 ILE g 256 ASP g 260 -1 O LYS g 257 N ALA g 250
SHEET 4 AG9 4 ILE g 265 LEU g 270 -1 O VAL g 267 N ILE g 258
LINK SG CYS a 23 ZN ZN a 201 1555 1555 2.62
LINK SG CYS a 26 ZN ZN a 201 1555 1555 2.30
LINK SG CYS a 74 ZN ZN a 201 1555 1555 2.37
LINK SG CYS a 77 ZN ZN a 201 1555 1555 2.25
LINK SG CYS d 21 ZN ZN d 201 1555 1555 2.37
LINK SG CYS d 24 ZN ZN d 201 1555 1555 2.33
LINK SG CYS d 39 ZN ZN d 201 1555 1555 2.29
LINK SG CYS d 42 ZN ZN d 201 1555 1555 2.37
LINK SG CYS f 121 ZN ZN f 500 1555 1555 2.35
LINK SG CYS f 126 ZN ZN f 500 1555 1555 2.34
LINK SG CYS f 141 ZN ZN f 500 1555 1555 2.36
LINK SG CYS f 144 ZN ZN f 500 1555 1555 2.35
CISPEP 1 ARG 0 279 VAL 0 280 0 29.60
CISPEP 2 LEU C 98 GLY C 99 0 3.46
CISPEP 3 ARG W 28 PRO W 29 0 -7.44
CISPEP 4 SER W 76 PRO W 77 0 2.78
SITE 1 AC1 4 CYS a 23 CYS a 26 CYS a 74 CYS a 77
SITE 1 AC2 4 CYS d 21 CYS d 24 CYS d 39 CYS d 42
SITE 1 AC3 4 CYS f 121 CYS f 126 CYS f 141 CYS f 144
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
(ATOM LINES ARE NOT SHOWN.)
END
