HEADER HYDROLASE 17-JAN-17 5UJ8
TITLE HUMAN ORIGIN RECOGNITION COMPLEX SUBUNITS 2 AND 3
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: ORIGIN RECOGNITION COMPLEX SUBUNIT 3;
COMPND 3 CHAIN: A, B, C, D;
COMPND 4 SYNONYM: ORIGIN RECOGNITION COMPLEX SUBUNIT LATHEO;
COMPND 5 ENGINEERED: YES;
COMPND 6 MOL_ID: 2;
COMPND 7 MOLECULE: ORIGIN RECOGNITION COMPLEX SUBUNIT 2;
COMPND 8 CHAIN: E, F, G, H;
COMPND 9 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 3 ORGANISM_COMMON: HUMAN;
SOURCE 4 ORGANISM_TAXID: 9606;
SOURCE 5 GENE: ORC3, LATHEO, ORC3L;
SOURCE 6 EXPRESSION_SYSTEM: SPODOPTERA AFF. FRUGIPERDA 2 RZ-2014;
SOURCE 7 EXPRESSION_SYSTEM_TAXID: 1491790;
SOURCE 8 MOL_ID: 2;
SOURCE 9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 10 ORGANISM_COMMON: HUMAN;
SOURCE 11 ORGANISM_TAXID: 9606;
SOURCE 12 GENE: ORC2, ORC2L;
SOURCE 13 EXPRESSION_SYSTEM: SPODOPTERA AFF. FRUGIPERDA 2 RZ-2014;
SOURCE 14 EXPRESSION_SYSTEM_TAXID: 1491790
KEYWDS ORC, REPLICATION, ATPASE, HYDROLASE
EXPDTA X-RAY DIFFRACTION
AUTHOR A.TOCILJ,K.F.ON,E.ELKAYAM,L.JOSHUA-TOR
REVDAT 2 04-OCT-23 5UJ8 1 REMARK
REVDAT 1 08-FEB-17 5UJ8 0
JRNL AUTH A.TOCILJ,K.F.ON,Z.YUAN,J.SUN,E.ELKAYAM,H.LI,B.STILLMAN,
JRNL AUTH 2 L.JOSHUA-TOR
JRNL TITL STRUCTURE OF THE ACTIVE FORM OF HUMAN ORIGIN RECOGNITION
JRNL TITL 2 COMPLEX AND ITS ATPASE MOTOR MODULE.
JRNL REF ELIFE V. 6 2017
JRNL REFN ESSN 2050-084X
JRNL PMID 28112645
JRNL DOI 10.7554/ELIFE.20818
REMARK 2
REMARK 2 RESOLUTION. 6.00 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 PROGRAM : PHENIX (1.10.1_2155: ???)
REMARK 3 AUTHORS : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK 3 : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK 3 : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK 3 : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK 3 : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK 3 : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK 3 : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK 3 : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK 3
REMARK 3 REFINEMENT TARGET : TWIN_LSQ_F
REMARK 3
REMARK 3 DATA USED IN REFINEMENT.
REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 6.00
REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 20.07
REMARK 3 MIN(FOBS/SIGMA_FOBS) : 1.340
REMARK 3 COMPLETENESS FOR RANGE (%) : 97.9
REMARK 3 NUMBER OF REFLECTIONS : 15179
REMARK 3
REMARK 3 FIT TO DATA USED IN REFINEMENT.
REMARK 3 R VALUE (WORKING + TEST SET) : 0.321
REMARK 3 R VALUE (WORKING SET) : 0.318
REMARK 3 FREE R VALUE : 0.369
REMARK 3 FREE R VALUE TEST SET SIZE (%) : 5.090
REMARK 3 FREE R VALUE TEST SET COUNT : 772
REMARK 3
REMARK 3 FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK 3 BIN RESOLUTION RANGE COMPL. NWORK NFREE RWORK RFREE
REMARK 3 1 19.4777 - 9.8904 0.92 2903 151 0.2722 0.3247
REMARK 3 2 9.8904 - 8.0292 0.91 2824 160 0.3232 0.3936
REMARK 3 3 8.0292 - 7.0696 0.94 2920 148 0.3688 0.4179
REMARK 3 4 7.0696 - 6.4489 0.94 2887 136 0.3629 0.3883
REMARK 3 5 6.4489 - 6.0012 0.93 2841 158 0.3804 0.4019
REMARK 3
REMARK 3 BULK SOLVENT MODELLING.
REMARK 3 METHOD USED : FLAT BULK SOLVENT MODEL
REMARK 3 SOLVENT RADIUS : 1.11
REMARK 3 SHRINKAGE RADIUS : 0.90
REMARK 3 K_SOL : NULL
REMARK 3 B_SOL : NULL
REMARK 3
REMARK 3 ERROR ESTIMATES.
REMARK 3 COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED) : NULL
REMARK 3 PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 52.600
REMARK 3
REMARK 3 B VALUES.
REMARK 3 FROM WILSON PLOT (A**2) : NULL
REMARK 3 MEAN B VALUE (OVERALL, A**2) : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE.
REMARK 3 B11 (A**2) : NULL
REMARK 3 B22 (A**2) : NULL
REMARK 3 B33 (A**2) : NULL
REMARK 3 B12 (A**2) : NULL
REMARK 3 B13 (A**2) : NULL
REMARK 3 B23 (A**2) : NULL
REMARK 3
REMARK 3 TWINNING INFORMATION.
REMARK 3 FRACTION: NULL
REMARK 3 OPERATOR: NULL
REMARK 3
REMARK 3 DEVIATIONS FROM IDEAL VALUES.
REMARK 3 RMSD COUNT
REMARK 3 BOND : 0.013 24656
REMARK 3 ANGLE : 1.293 33360
REMARK 3 CHIRALITY : 0.059 3860
REMARK 3 PLANARITY : 0.009 4164
REMARK 3 DIHEDRAL : 11.193 14908
REMARK 3
REMARK 3 TLS DETAILS
REMARK 3 NUMBER OF TLS GROUPS : NULL
REMARK 3
REMARK 3 NCS DETAILS
REMARK 3 NUMBER OF NCS GROUPS : NULL
REMARK 3
REMARK 3 OTHER REFINEMENT REMARKS: NULL
REMARK 4
REMARK 4 5UJ8 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 19-JAN-17.
REMARK 100 THE DEPOSITION ID IS D_1000225120.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION
REMARK 200 DATE OF DATA COLLECTION : 24-FEB-16
REMARK 200 TEMPERATURE (KELVIN) : 100
REMARK 200 PH : NULL
REMARK 200 NUMBER OF CRYSTALS USED : 1
REMARK 200
REMARK 200 SYNCHROTRON (Y/N) : Y
REMARK 200 RADIATION SOURCE : APS
REMARK 200 BEAMLINE : 19-ID
REMARK 200 X-RAY GENERATOR MODEL : NULL
REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M
REMARK 200 WAVELENGTH OR RANGE (A) : 0.97926
REMARK 200 MONOCHROMATOR : NULL
REMARK 200 OPTICS : NULL
REMARK 200
REMARK 200 DETECTOR TYPE : PIXEL
REMARK 200 DETECTOR MANUFACTURER : DECTRIS PILATUS3 6M
REMARK 200 INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200 DATA SCALING SOFTWARE : AIMLESS
REMARK 200
REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 15179
REMARK 200 RESOLUTION RANGE HIGH (A) : 6.000
REMARK 200 RESOLUTION RANGE LOW (A) : 20.070
REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200 COMPLETENESS FOR RANGE (%) : 95.0
REMARK 200 DATA REDUNDANCY : 3.400
REMARK 200 R MERGE (I) : NULL
REMARK 200 R SYM (I) : NULL
REMARK 200 <I/SIGMA(I)> FOR THE DATA SET : 5.7000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 6.00
REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 6.21
REMARK 200 COMPLETENESS FOR SHELL (%) : 99.1
REMARK 200 DATA REDUNDANCY IN SHELL : 3.60
REMARK 200 R MERGE FOR SHELL (I) : NULL
REMARK 200 R SYM FOR SHELL (I) : NULL
REMARK 200 <I/SIGMA(I)> FOR SHELL : 1.000
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: 4XGC - CHAINS B,C
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS (%): 61.95
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.23
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 9.5% PEG20000 50MM TRI-SODIUM-CITRATE
REMARK 280 60MM CITRIC ACID 10MG/ML HO23 RATIO 1:1, VAPOR DIFFUSION,
REMARK 280 SITTING DROP, TEMPERATURE 290K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290 SYMOP SYMMETRY
REMARK 290 NNNMMM OPERATOR
REMARK 290 1555 X,Y,Z
REMARK 290 2555 -X,Y+1/2,-Z
REMARK 290
REMARK 290 WHERE NNN -> OPERATOR NUMBER
REMARK 290 MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000
REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000
REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000
REMARK 290 SMTRY1 2 -1.000000 0.000000 0.000000 0.00000
REMARK 290 SMTRY2 2 0.000000 1.000000 0.000000 57.48050
REMARK 290 SMTRY3 2 0.000000 0.000000 -1.000000 0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2, 3, 4, 5, 6
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 2690 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 38480 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -20.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, G
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 2740 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 38370 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -20.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, E
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 3
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 3290 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 37780 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -24.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, H
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 4
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 2940 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 38160 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -21.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D, F
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 5
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 8860 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 73370 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -60.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, G
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, H
REMARK 350 BIOMT1 2 1.000000 0.000000 0.000000 87.26000
REMARK 350 BIOMT2 2 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 2 0.000000 0.000000 1.000000 0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 6
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 8720 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 73490 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -58.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, E
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D, F
REMARK 350 BIOMT1 2 1.000000 0.000000 0.000000 87.26000
REMARK 350 BIOMT2 2 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 2 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A 1
REMARK 465 ALA A 2
REMARK 465 THR A 3
REMARK 465 SER A 4
REMARK 465 SER A 5
REMARK 465 MET A 6
REMARK 465 SER A 7
REMARK 465 LYS A 8
REMARK 465 GLY A 9
REMARK 465 CYS A 10
REMARK 465 PHE A 11
REMARK 465 VAL A 12
REMARK 465 PHE A 13
REMARK 465 LYS A 14
REMARK 465 PRO A 15
REMARK 465 ASN A 16
REMARK 465 SER A 17
REMARK 465 LYS A 18
REMARK 465 LYS A 19
REMARK 465 ARG A 20
REMARK 465 LYS A 21
REMARK 465 ILE A 22
REMARK 465 SER A 23
REMARK 465 LEU A 24
REMARK 465 PRO A 25
REMARK 465 ILE A 26
REMARK 465 GLU A 27
REMARK 465 ASP A 28
REMARK 465 TYR A 29
REMARK 465 PHE A 30
REMARK 465 ASN A 31
REMARK 465 LYS A 32
REMARK 465 GLY A 33
REMARK 465 LYS A 34
REMARK 465 ASN A 35
REMARK 465 GLU A 36
REMARK 465 PRO A 37
REMARK 465 GLU A 38
REMARK 465 ASP A 39
REMARK 465 SER A 40
REMARK 465 PHE A 84
REMARK 465 GLN A 85
REMARK 465 LYS A 86
REMARK 465 ASN A 87
REMARK 465 SER A 88
REMARK 465 ARG A 89
REMARK 465 ASP A 90
REMARK 465 LEU A 91
REMARK 465 GLY A 92
REMARK 465 GLY A 93
REMARK 465 GLN A 94
REMARK 465 ILE A 95
REMARK 465 LYS A 96
REMARK 465 LYS A 165
REMARK 465 GLU A 166
REMARK 465 GLU A 167
REMARK 465 GLU A 168
REMARK 465 SER A 169
REMARK 465 VAL A 170
REMARK 465 HIS A 171
REMARK 465 VAL A 172
REMARK 465 THR A 173
REMARK 465 GLN A 174
REMARK 465 ARG A 175
REMARK 465 LYS A 176
REMARK 465 THR A 177
REMARK 465 HIS A 178
REMARK 465 TYR A 179
REMARK 465 SER A 180
REMARK 465 MET A 181
REMARK 465 ASP A 182
REMARK 465 SER A 183
REMARK 465 LEU A 184
REMARK 465 SER A 185
REMARK 465 SER A 186
REMARK 465 TRP A 187
REMARK 465 GLU A 507
REMARK 465 THR A 508
REMARK 465 LYS A 509
REMARK 465 GLU A 510
REMARK 465 GLU A 511
REMARK 465 GLU A 512
REMARK 465 ASP A 513
REMARK 465 ALA A 514
REMARK 465 SER A 515
REMARK 465 GLY A 516
REMARK 465 SER A 517
REMARK 465 GLN A 518
REMARK 465 PRO A 519
REMARK 465 LYS A 520
REMARK 465 GLY A 521
REMARK 465 LEU A 522
REMARK 465 GLN A 523
REMARK 465 LYS A 524
REMARK 465 THR A 525
REMARK 465 ASP A 526
REMARK 465 LEU A 527
REMARK 465 TYR A 528
REMARK 465 HIS A 529
REMARK 465 LEU A 530
REMARK 465 GLN A 531
REMARK 465 LYS A 532
REMARK 465 SER A 533
REMARK 465 LEU A 534
REMARK 465 LEU A 535
REMARK 465 GLU A 536
REMARK 465 MET A 537
REMARK 465 LYS A 538
REMARK 465 GLU A 539
REMARK 465 LEU A 540
REMARK 465 ARG A 541
REMARK 465 ARG A 542
REMARK 465 SER A 543
REMARK 465 LYS A 544
REMARK 465 LYS A 545
REMARK 465 GLN A 546
REMARK 465 THR A 547
REMARK 465 PRO A 607
REMARK 465 TYR A 608
REMARK 465 TYR A 609
REMARK 465 TYR A 610
REMARK 465 LEU A 611
REMARK 465 LYS A 612
REMARK 465 ASN A 613
REMARK 465 GLU A 614
REMARK 465 ALA A 615
REMARK 465 LEU A 616
REMARK 465 LYS A 617
REMARK 465 SER A 618
REMARK 465 GLU A 619
REMARK 465 GLU A 620
REMARK 465 GLY A 621
REMARK 465 CYS A 622
REMARK 465 ILE A 623
REMARK 465 PRO A 624
REMARK 465 ASN A 625
REMARK 465 ILE A 626
REMARK 465 ALA A 627
REMARK 465 THR A 658
REMARK 465 ALA A 659
REMARK 465 ALA A 660
REMARK 465 GLU A 661
REMARK 465 LYS A 662
REMARK 465 MET A 663
REMARK 465 ASP A 664
REMARK 465 ALA A 665
REMARK 465 ASN A 666
REMARK 465 SER A 667
REMARK 465 ALA A 668
REMARK 465 THR A 669
REMARK 465 SER A 670
REMARK 465 GLU A 671
REMARK 465 GLU A 672
REMARK 465 MET A 673
REMARK 465 ASN A 674
REMARK 465 GLU A 675
REMARK 465 GLY A 710
REMARK 465 GLY A 711
REMARK 465 CYS A 712
REMARK 465 MET B 1
REMARK 465 ALA B 2
REMARK 465 THR B 3
REMARK 465 SER B 4
REMARK 465 SER B 5
REMARK 465 MET B 6
REMARK 465 SER B 7
REMARK 465 LYS B 8
REMARK 465 GLY B 9
REMARK 465 CYS B 10
REMARK 465 PHE B 11
REMARK 465 VAL B 12
REMARK 465 PHE B 13
REMARK 465 LYS B 14
REMARK 465 PRO B 15
REMARK 465 ASN B 16
REMARK 465 SER B 17
REMARK 465 LYS B 18
REMARK 465 LYS B 19
REMARK 465 ARG B 20
REMARK 465 LYS B 21
REMARK 465 ILE B 22
REMARK 465 SER B 23
REMARK 465 LEU B 24
REMARK 465 PRO B 25
REMARK 465 ILE B 26
REMARK 465 GLU B 27
REMARK 465 ASP B 28
REMARK 465 TYR B 29
REMARK 465 PHE B 30
REMARK 465 ASN B 31
REMARK 465 LYS B 32
REMARK 465 GLY B 33
REMARK 465 LYS B 34
REMARK 465 ASN B 35
REMARK 465 GLU B 36
REMARK 465 PRO B 37
REMARK 465 GLU B 38
REMARK 465 ASP B 39
REMARK 465 SER B 40
REMARK 465 PHE B 84
REMARK 465 GLN B 85
REMARK 465 LYS B 86
REMARK 465 ASN B 87
REMARK 465 SER B 88
REMARK 465 ARG B 89
REMARK 465 ASP B 90
REMARK 465 LEU B 91
REMARK 465 GLY B 92
REMARK 465 GLY B 93
REMARK 465 GLN B 94
REMARK 465 ILE B 95
REMARK 465 LYS B 96
REMARK 465 LYS B 165
REMARK 465 GLU B 166
REMARK 465 GLU B 167
REMARK 465 GLU B 168
REMARK 465 SER B 169
REMARK 465 VAL B 170
REMARK 465 HIS B 171
REMARK 465 VAL B 172
REMARK 465 THR B 173
REMARK 465 GLN B 174
REMARK 465 ARG B 175
REMARK 465 LYS B 176
REMARK 465 THR B 177
REMARK 465 HIS B 178
REMARK 465 TYR B 179
REMARK 465 SER B 180
REMARK 465 MET B 181
REMARK 465 ASP B 182
REMARK 465 SER B 183
REMARK 465 LEU B 184
REMARK 465 SER B 185
REMARK 465 SER B 186
REMARK 465 TRP B 187
REMARK 465 GLU B 507
REMARK 465 THR B 508
REMARK 465 LYS B 509
REMARK 465 GLU B 510
REMARK 465 GLU B 511
REMARK 465 GLU B 512
REMARK 465 ASP B 513
REMARK 465 ALA B 514
REMARK 465 SER B 515
REMARK 465 GLY B 516
REMARK 465 SER B 517
REMARK 465 GLN B 518
REMARK 465 PRO B 519
REMARK 465 LYS B 520
REMARK 465 GLY B 521
REMARK 465 LEU B 522
REMARK 465 GLN B 523
REMARK 465 LYS B 524
REMARK 465 THR B 525
REMARK 465 ASP B 526
REMARK 465 LEU B 527
REMARK 465 TYR B 528
REMARK 465 HIS B 529
REMARK 465 LEU B 530
REMARK 465 GLN B 531
REMARK 465 LYS B 532
REMARK 465 SER B 533
REMARK 465 LEU B 534
REMARK 465 LEU B 535
REMARK 465 GLU B 536
REMARK 465 MET B 537
REMARK 465 LYS B 538
REMARK 465 GLU B 539
REMARK 465 LEU B 540
REMARK 465 ARG B 541
REMARK 465 ARG B 542
REMARK 465 SER B 543
REMARK 465 LYS B 544
REMARK 465 LYS B 545
REMARK 465 GLN B 546
REMARK 465 THR B 547
REMARK 465 PRO B 607
REMARK 465 TYR B 608
REMARK 465 TYR B 609
REMARK 465 TYR B 610
REMARK 465 LEU B 611
REMARK 465 LYS B 612
REMARK 465 ASN B 613
REMARK 465 GLU B 614
REMARK 465 ALA B 615
REMARK 465 LEU B 616
REMARK 465 LYS B 617
REMARK 465 SER B 618
REMARK 465 GLU B 619
REMARK 465 GLU B 620
REMARK 465 GLY B 621
REMARK 465 CYS B 622
REMARK 465 ILE B 623
REMARK 465 PRO B 624
REMARK 465 ASN B 625
REMARK 465 ILE B 626
REMARK 465 ALA B 627
REMARK 465 THR B 658
REMARK 465 ALA B 659
REMARK 465 ALA B 660
REMARK 465 GLU B 661
REMARK 465 LYS B 662
REMARK 465 MET B 663
REMARK 465 ASP B 664
REMARK 465 ALA B 665
REMARK 465 ASN B 666
REMARK 465 SER B 667
REMARK 465 ALA B 668
REMARK 465 THR B 669
REMARK 465 SER B 670
REMARK 465 GLU B 671
REMARK 465 GLU B 672
REMARK 465 MET B 673
REMARK 465 ASN B 674
REMARK 465 GLU B 675
REMARK 465 GLY B 710
REMARK 465 GLY B 711
REMARK 465 CYS B 712
REMARK 465 MET C 1
REMARK 465 ALA C 2
REMARK 465 THR C 3
REMARK 465 SER C 4
REMARK 465 SER C 5
REMARK 465 MET C 6
REMARK 465 SER C 7
REMARK 465 LYS C 8
REMARK 465 GLY C 9
REMARK 465 CYS C 10
REMARK 465 PHE C 11
REMARK 465 VAL C 12
REMARK 465 PHE C 13
REMARK 465 LYS C 14
REMARK 465 PRO C 15
REMARK 465 ASN C 16
REMARK 465 SER C 17
REMARK 465 LYS C 18
REMARK 465 LYS C 19
REMARK 465 ARG C 20
REMARK 465 LYS C 21
REMARK 465 ILE C 22
REMARK 465 SER C 23
REMARK 465 LEU C 24
REMARK 465 PRO C 25
REMARK 465 ILE C 26
REMARK 465 GLU C 27
REMARK 465 ASP C 28
REMARK 465 TYR C 29
REMARK 465 PHE C 30
REMARK 465 ASN C 31
REMARK 465 LYS C 32
REMARK 465 GLY C 33
REMARK 465 LYS C 34
REMARK 465 ASN C 35
REMARK 465 GLU C 36
REMARK 465 PRO C 37
REMARK 465 GLU C 38
REMARK 465 ASP C 39
REMARK 465 SER C 40
REMARK 465 PHE C 84
REMARK 465 GLN C 85
REMARK 465 LYS C 86
REMARK 465 ASN C 87
REMARK 465 SER C 88
REMARK 465 ARG C 89
REMARK 465 ASP C 90
REMARK 465 LEU C 91
REMARK 465 GLY C 92
REMARK 465 GLY C 93
REMARK 465 GLN C 94
REMARK 465 ILE C 95
REMARK 465 LYS C 96
REMARK 465 LYS C 165
REMARK 465 GLU C 166
REMARK 465 GLU C 167
REMARK 465 GLU C 168
REMARK 465 SER C 169
REMARK 465 VAL C 170
REMARK 465 HIS C 171
REMARK 465 VAL C 172
REMARK 465 THR C 173
REMARK 465 GLN C 174
REMARK 465 ARG C 175
REMARK 465 LYS C 176
REMARK 465 THR C 177
REMARK 465 HIS C 178
REMARK 465 TYR C 179
REMARK 465 SER C 180
REMARK 465 MET C 181
REMARK 465 ASP C 182
REMARK 465 SER C 183
REMARK 465 LEU C 184
REMARK 465 SER C 185
REMARK 465 SER C 186
REMARK 465 TRP C 187
REMARK 465 GLU C 507
REMARK 465 THR C 508
REMARK 465 LYS C 509
REMARK 465 GLU C 510
REMARK 465 GLU C 511
REMARK 465 GLU C 512
REMARK 465 ASP C 513
REMARK 465 ALA C 514
REMARK 465 SER C 515
REMARK 465 GLY C 516
REMARK 465 SER C 517
REMARK 465 GLN C 518
REMARK 465 PRO C 519
REMARK 465 LYS C 520
REMARK 465 GLY C 521
REMARK 465 LEU C 522
REMARK 465 GLN C 523
REMARK 465 LYS C 524
REMARK 465 THR C 525
REMARK 465 ASP C 526
REMARK 465 LEU C 527
REMARK 465 TYR C 528
REMARK 465 HIS C 529
REMARK 465 LEU C 530
REMARK 465 GLN C 531
REMARK 465 LYS C 532
REMARK 465 SER C 533
REMARK 465 LEU C 534
REMARK 465 LEU C 535
REMARK 465 GLU C 536
REMARK 465 MET C 537
REMARK 465 LYS C 538
REMARK 465 GLU C 539
REMARK 465 LEU C 540
REMARK 465 ARG C 541
REMARK 465 ARG C 542
REMARK 465 SER C 543
REMARK 465 LYS C 544
REMARK 465 LYS C 545
REMARK 465 GLN C 546
REMARK 465 THR C 547
REMARK 465 PRO C 607
REMARK 465 TYR C 608
REMARK 465 TYR C 609
REMARK 465 TYR C 610
REMARK 465 LEU C 611
REMARK 465 LYS C 612
REMARK 465 ASN C 613
REMARK 465 GLU C 614
REMARK 465 ALA C 615
REMARK 465 LEU C 616
REMARK 465 LYS C 617
REMARK 465 SER C 618
REMARK 465 GLU C 619
REMARK 465 GLU C 620
REMARK 465 GLY C 621
REMARK 465 CYS C 622
REMARK 465 ILE C 623
REMARK 465 PRO C 624
REMARK 465 ASN C 625
REMARK 465 ILE C 626
REMARK 465 ALA C 627
REMARK 465 THR C 658
REMARK 465 ALA C 659
REMARK 465 ALA C 660
REMARK 465 GLU C 661
REMARK 465 LYS C 662
REMARK 465 MET C 663
REMARK 465 ASP C 664
REMARK 465 ALA C 665
REMARK 465 ASN C 666
REMARK 465 SER C 667
REMARK 465 ALA C 668
REMARK 465 THR C 669
REMARK 465 SER C 670
REMARK 465 GLU C 671
REMARK 465 GLU C 672
REMARK 465 MET C 673
REMARK 465 ASN C 674
REMARK 465 GLU C 675
REMARK 465 GLY C 710
REMARK 465 GLY C 711
REMARK 465 CYS C 712
REMARK 465 MET D 1
REMARK 465 ALA D 2
REMARK 465 THR D 3
REMARK 465 SER D 4
REMARK 465 SER D 5
REMARK 465 MET D 6
REMARK 465 SER D 7
REMARK 465 LYS D 8
REMARK 465 GLY D 9
REMARK 465 CYS D 10
REMARK 465 PHE D 11
REMARK 465 VAL D 12
REMARK 465 PHE D 13
REMARK 465 LYS D 14
REMARK 465 PRO D 15
REMARK 465 ASN D 16
REMARK 465 SER D 17
REMARK 465 LYS D 18
REMARK 465 LYS D 19
REMARK 465 ARG D 20
REMARK 465 LYS D 21
REMARK 465 ILE D 22
REMARK 465 SER D 23
REMARK 465 LEU D 24
REMARK 465 PRO D 25
REMARK 465 ILE D 26
REMARK 465 GLU D 27
REMARK 465 ASP D 28
REMARK 465 TYR D 29
REMARK 465 PHE D 30
REMARK 465 ASN D 31
REMARK 465 LYS D 32
REMARK 465 GLY D 33
REMARK 465 LYS D 34
REMARK 465 ASN D 35
REMARK 465 GLU D 36
REMARK 465 PRO D 37
REMARK 465 GLU D 38
REMARK 465 ASP D 39
REMARK 465 SER D 40
REMARK 465 PHE D 84
REMARK 465 GLN D 85
REMARK 465 LYS D 86
REMARK 465 ASN D 87
REMARK 465 SER D 88
REMARK 465 ARG D 89
REMARK 465 ASP D 90
REMARK 465 LEU D 91
REMARK 465 GLY D 92
REMARK 465 GLY D 93
REMARK 465 GLN D 94
REMARK 465 ILE D 95
REMARK 465 LYS D 96
REMARK 465 LYS D 165
REMARK 465 GLU D 166
REMARK 465 GLU D 167
REMARK 465 GLU D 168
REMARK 465 SER D 169
REMARK 465 VAL D 170
REMARK 465 HIS D 171
REMARK 465 VAL D 172
REMARK 465 THR D 173
REMARK 465 GLN D 174
REMARK 465 ARG D 175
REMARK 465 LYS D 176
REMARK 465 THR D 177
REMARK 465 HIS D 178
REMARK 465 TYR D 179
REMARK 465 SER D 180
REMARK 465 MET D 181
REMARK 465 ASP D 182
REMARK 465 SER D 183
REMARK 465 LEU D 184
REMARK 465 SER D 185
REMARK 465 SER D 186
REMARK 465 TRP D 187
REMARK 465 GLU D 507
REMARK 465 THR D 508
REMARK 465 LYS D 509
REMARK 465 GLU D 510
REMARK 465 GLU D 511
REMARK 465 GLU D 512
REMARK 465 ASP D 513
REMARK 465 ALA D 514
REMARK 465 SER D 515
REMARK 465 GLY D 516
REMARK 465 SER D 517
REMARK 465 GLN D 518
REMARK 465 PRO D 519
REMARK 465 LYS D 520
REMARK 465 GLY D 521
REMARK 465 LEU D 522
REMARK 465 GLN D 523
REMARK 465 LYS D 524
REMARK 465 THR D 525
REMARK 465 ASP D 526
REMARK 465 LEU D 527
REMARK 465 TYR D 528
REMARK 465 HIS D 529
REMARK 465 LEU D 530
REMARK 465 GLN D 531
REMARK 465 LYS D 532
REMARK 465 SER D 533
REMARK 465 LEU D 534
REMARK 465 LEU D 535
REMARK 465 GLU D 536
REMARK 465 MET D 537
REMARK 465 LYS D 538
REMARK 465 GLU D 539
REMARK 465 LEU D 540
REMARK 465 ARG D 541
REMARK 465 ARG D 542
REMARK 465 SER D 543
REMARK 465 LYS D 544
REMARK 465 LYS D 545
REMARK 465 GLN D 546
REMARK 465 THR D 547
REMARK 465 PRO D 607
REMARK 465 TYR D 608
REMARK 465 TYR D 609
REMARK 465 TYR D 610
REMARK 465 LEU D 611
REMARK 465 LYS D 612
REMARK 465 ASN D 613
REMARK 465 GLU D 614
REMARK 465 ALA D 615
REMARK 465 LEU D 616
REMARK 465 LYS D 617
REMARK 465 SER D 618
REMARK 465 GLU D 619
REMARK 465 GLU D 620
REMARK 465 GLY D 621
REMARK 465 CYS D 622
REMARK 465 ILE D 623
REMARK 465 PRO D 624
REMARK 465 ASN D 625
REMARK 465 ILE D 626
REMARK 465 ALA D 627
REMARK 465 THR D 658
REMARK 465 ALA D 659
REMARK 465 ALA D 660
REMARK 465 GLU D 661
REMARK 465 LYS D 662
REMARK 465 MET D 663
REMARK 465 ASP D 664
REMARK 465 ALA D 665
REMARK 465 ASN D 666
REMARK 465 SER D 667
REMARK 465 ALA D 668
REMARK 465 THR D 669
REMARK 465 SER D 670
REMARK 465 GLU D 671
REMARK 465 GLU D 672
REMARK 465 MET D 673
REMARK 465 ASN D 674
REMARK 465 GLU D 675
REMARK 465 GLY D 710
REMARK 465 GLY D 711
REMARK 465 CYS D 712
REMARK 465 MET E 231
REMARK 465 LYS E 232
REMARK 465 ARG E 233
REMARK 465 ASP E 234
REMARK 465 LYS E 235
REMARK 465 THR E 236
REMARK 465 SER E 237
REMARK 465 ASP E 238
REMARK 465 LEU E 239
REMARK 465 VAL E 240
REMARK 465 GLU E 241
REMARK 465 GLU E 242
REMARK 465 TYR E 243
REMARK 465 PHE E 244
REMARK 465 GLU E 245
REMARK 465 ALA E 246
REMARK 465 HIS E 247
REMARK 465 SER E 248
REMARK 465 SER E 249
REMARK 465 SER E 250
REMARK 465 LYS E 251
REMARK 465 VAL E 252
REMARK 465 LEU E 253
REMARK 465 THR E 254
REMARK 465 SER E 255
REMARK 465 ASP E 256
REMARK 465 ARG E 257
REMARK 465 THR E 258
REMARK 465 LEU E 259
REMARK 465 GLN E 260
REMARK 465 LYS E 261
REMARK 465 LEU E 262
REMARK 465 LYS E 263
REMARK 465 ARG E 264
REMARK 465 ALA E 265
REMARK 465 LYS E 266
REMARK 465 LEU E 267
REMARK 465 ASP E 268
REMARK 465 GLN E 269
REMARK 465 GLN E 270
REMARK 465 THR E 271
REMARK 465 LEU E 272
REMARK 465 ARG E 273
REMARK 465 ASN E 274
REMARK 465 LEU E 275
REMARK 465 LEU E 276
REMARK 465 SER E 277
REMARK 465 LYS E 278
REMARK 465 VAL E 279
REMARK 465 SER E 280
REMARK 465 PRO E 281
REMARK 465 SER E 282
REMARK 465 PHE E 283
REMARK 465 LYS E 467
REMARK 465 GLN E 468
REMARK 465 SER E 469
REMARK 465 GLY E 470
REMARK 465 SER E 471
REMARK 465 LEU E 472
REMARK 465 PRO E 473
REMARK 465 LEU E 474
REMARK 465 SER E 475
REMARK 465 SER E 476
REMARK 465 LEU E 477
REMARK 465 THR E 478
REMARK 465 HIS E 479
REMARK 465 VAL E 480
REMARK 465 LEU E 481
REMARK 465 ARG E 482
REMARK 465 SER E 483
REMARK 465 LEU E 484
REMARK 465 THR E 485
REMARK 465 PRO E 486
REMARK 465 ASN E 487
REMARK 465 ALA E 488
REMARK 465 ARG E 489
REMARK 465 GLY E 490
REMARK 465 ILE E 491
REMARK 465 PHE E 492
REMARK 465 ARG E 493
REMARK 465 LEU E 494
REMARK 465 LEU E 495
REMARK 465 ILE E 496
REMARK 465 LYS E 497
REMARK 465 TYR E 498
REMARK 465 GLN E 499
REMARK 465 LEU E 500
REMARK 465 ASP E 501
REMARK 465 ASN E 502
REMARK 465 GLN E 503
REMARK 465 ASP E 504
REMARK 465 ASN E 505
REMARK 465 PRO E 506
REMARK 465 SER E 507
REMARK 465 TYR E 508
REMARK 465 ILE E 509
REMARK 465 GLY E 510
REMARK 465 LEU E 511
REMARK 465 SER E 512
REMARK 465 PHE E 513
REMARK 465 GLN E 514
REMARK 465 ASP E 515
REMARK 465 PHE E 516
REMARK 465 TYR E 517
REMARK 465 GLN E 518
REMARK 465 GLN E 519
REMARK 465 CYS E 520
REMARK 465 ARG E 521
REMARK 465 GLU E 522
REMARK 465 ALA E 523
REMARK 465 PHE E 524
REMARK 465 LEU E 525
REMARK 465 VAL E 526
REMARK 465 ASN E 527
REMARK 465 SER E 528
REMARK 465 ASP E 529
REMARK 465 LEU E 530
REMARK 465 THR E 531
REMARK 465 LEU E 532
REMARK 465 ARG E 533
REMARK 465 ALA E 534
REMARK 465 GLN E 535
REMARK 465 LEU E 536
REMARK 465 THR E 537
REMARK 465 GLU E 538
REMARK 465 PHE E 539
REMARK 465 ARG E 540
REMARK 465 ASP E 541
REMARK 465 HIS E 542
REMARK 465 LYS E 543
REMARK 465 LEU E 544
REMARK 465 ILE E 545
REMARK 465 ARG E 546
REMARK 465 THR E 547
REMARK 465 LYS E 548
REMARK 465 LYS E 549
REMARK 465 GLY E 550
REMARK 465 THR E 551
REMARK 465 ASP E 552
REMARK 465 GLY E 553
REMARK 465 VAL E 554
REMARK 465 GLU E 555
REMARK 465 TYR E 556
REMARK 465 LEU E 557
REMARK 465 LEU E 558
REMARK 465 ILE E 559
REMARK 465 PRO E 560
REMARK 465 VAL E 561
REMARK 465 ASP E 562
REMARK 465 ASN E 563
REMARK 465 GLY E 564
REMARK 465 THR E 565
REMARK 465 LEU E 566
REMARK 465 THR E 567
REMARK 465 ASP E 568
REMARK 465 PHE E 569
REMARK 465 LEU E 570
REMARK 465 GLU E 571
REMARK 465 LYS E 572
REMARK 465 GLU E 573
REMARK 465 GLU E 574
REMARK 465 GLU E 575
REMARK 465 GLU E 576
REMARK 465 ALA E 577
REMARK 465 MET F 231
REMARK 465 LYS F 232
REMARK 465 ARG F 233
REMARK 465 ASP F 234
REMARK 465 LYS F 235
REMARK 465 THR F 236
REMARK 465 SER F 237
REMARK 465 ASP F 238
REMARK 465 LEU F 239
REMARK 465 VAL F 240
REMARK 465 GLU F 241
REMARK 465 GLU F 242
REMARK 465 TYR F 243
REMARK 465 PHE F 244
REMARK 465 GLU F 245
REMARK 465 ALA F 246
REMARK 465 HIS F 247
REMARK 465 SER F 248
REMARK 465 SER F 249
REMARK 465 SER F 250
REMARK 465 LYS F 251
REMARK 465 VAL F 252
REMARK 465 LEU F 253
REMARK 465 THR F 254
REMARK 465 SER F 255
REMARK 465 ASP F 256
REMARK 465 ARG F 257
REMARK 465 THR F 258
REMARK 465 LEU F 259
REMARK 465 GLN F 260
REMARK 465 LYS F 261
REMARK 465 LEU F 262
REMARK 465 LYS F 263
REMARK 465 ARG F 264
REMARK 465 ALA F 265
REMARK 465 LYS F 266
REMARK 465 LEU F 267
REMARK 465 ASP F 268
REMARK 465 GLN F 269
REMARK 465 GLN F 270
REMARK 465 THR F 271
REMARK 465 LEU F 272
REMARK 465 ARG F 273
REMARK 465 ASN F 274
REMARK 465 LEU F 275
REMARK 465 LEU F 276
REMARK 465 SER F 277
REMARK 465 LYS F 278
REMARK 465 VAL F 279
REMARK 465 SER F 280
REMARK 465 PRO F 281
REMARK 465 SER F 282
REMARK 465 PHE F 283
REMARK 465 LYS F 467
REMARK 465 GLN F 468
REMARK 465 SER F 469
REMARK 465 GLY F 470
REMARK 465 SER F 471
REMARK 465 LEU F 472
REMARK 465 PRO F 473
REMARK 465 LEU F 474
REMARK 465 SER F 475
REMARK 465 SER F 476
REMARK 465 LEU F 477
REMARK 465 THR F 478
REMARK 465 HIS F 479
REMARK 465 VAL F 480
REMARK 465 LEU F 481
REMARK 465 ARG F 482
REMARK 465 SER F 483
REMARK 465 LEU F 484
REMARK 465 THR F 485
REMARK 465 PRO F 486
REMARK 465 ASN F 487
REMARK 465 ALA F 488
REMARK 465 ARG F 489
REMARK 465 GLY F 490
REMARK 465 ILE F 491
REMARK 465 PHE F 492
REMARK 465 ARG F 493
REMARK 465 LEU F 494
REMARK 465 LEU F 495
REMARK 465 ILE F 496
REMARK 465 LYS F 497
REMARK 465 TYR F 498
REMARK 465 GLN F 499
REMARK 465 LEU F 500
REMARK 465 ASP F 501
REMARK 465 ASN F 502
REMARK 465 GLN F 503
REMARK 465 ASP F 504
REMARK 465 ASN F 505
REMARK 465 PRO F 506
REMARK 465 SER F 507
REMARK 465 TYR F 508
REMARK 465 ILE F 509
REMARK 465 GLY F 510
REMARK 465 LEU F 511
REMARK 465 SER F 512
REMARK 465 PHE F 513
REMARK 465 GLN F 514
REMARK 465 ASP F 515
REMARK 465 PHE F 516
REMARK 465 TYR F 517
REMARK 465 GLN F 518
REMARK 465 GLN F 519
REMARK 465 CYS F 520
REMARK 465 ARG F 521
REMARK 465 GLU F 522
REMARK 465 ALA F 523
REMARK 465 PHE F 524
REMARK 465 LEU F 525
REMARK 465 VAL F 526
REMARK 465 ASN F 527
REMARK 465 SER F 528
REMARK 465 ASP F 529
REMARK 465 LEU F 530
REMARK 465 THR F 531
REMARK 465 LEU F 532
REMARK 465 ARG F 533
REMARK 465 ALA F 534
REMARK 465 GLN F 535
REMARK 465 LEU F 536
REMARK 465 THR F 537
REMARK 465 GLU F 538
REMARK 465 PHE F 539
REMARK 465 ARG F 540
REMARK 465 ASP F 541
REMARK 465 HIS F 542
REMARK 465 LYS F 543
REMARK 465 LEU F 544
REMARK 465 ILE F 545
REMARK 465 ARG F 546
REMARK 465 THR F 547
REMARK 465 LYS F 548
REMARK 465 LYS F 549
REMARK 465 GLY F 550
REMARK 465 THR F 551
REMARK 465 ASP F 552
REMARK 465 GLY F 553
REMARK 465 VAL F 554
REMARK 465 GLU F 555
REMARK 465 TYR F 556
REMARK 465 LEU F 557
REMARK 465 LEU F 558
REMARK 465 ILE F 559
REMARK 465 PRO F 560
REMARK 465 VAL F 561
REMARK 465 ASP F 562
REMARK 465 ASN F 563
REMARK 465 GLY F 564
REMARK 465 THR F 565
REMARK 465 LEU F 566
REMARK 465 THR F 567
REMARK 465 ASP F 568
REMARK 465 PHE F 569
REMARK 465 LEU F 570
REMARK 465 GLU F 571
REMARK 465 LYS F 572
REMARK 465 GLU F 573
REMARK 465 GLU F 574
REMARK 465 GLU F 575
REMARK 465 GLU F 576
REMARK 465 ALA F 577
REMARK 465 MET G 231
REMARK 465 LYS G 232
REMARK 465 ARG G 233
REMARK 465 ASP G 234
REMARK 465 LYS G 235
REMARK 465 THR G 236
REMARK 465 SER G 237
REMARK 465 ASP G 238
REMARK 465 LEU G 239
REMARK 465 VAL G 240
REMARK 465 GLU G 241
REMARK 465 GLU G 242
REMARK 465 TYR G 243
REMARK 465 PHE G 244
REMARK 465 GLU G 245
REMARK 465 ALA G 246
REMARK 465 HIS G 247
REMARK 465 SER G 248
REMARK 465 SER G 249
REMARK 465 SER G 250
REMARK 465 LYS G 251
REMARK 465 VAL G 252
REMARK 465 LEU G 253
REMARK 465 THR G 254
REMARK 465 SER G 255
REMARK 465 ASP G 256
REMARK 465 ARG G 257
REMARK 465 THR G 258
REMARK 465 LEU G 259
REMARK 465 GLN G 260
REMARK 465 LYS G 261
REMARK 465 LEU G 262
REMARK 465 LYS G 263
REMARK 465 ARG G 264
REMARK 465 ALA G 265
REMARK 465 LYS G 266
REMARK 465 LEU G 267
REMARK 465 ASP G 268
REMARK 465 GLN G 269
REMARK 465 GLN G 270
REMARK 465 THR G 271
REMARK 465 LEU G 272
REMARK 465 ARG G 273
REMARK 465 ASN G 274
REMARK 465 LEU G 275
REMARK 465 LEU G 276
REMARK 465 SER G 277
REMARK 465 LYS G 278
REMARK 465 VAL G 279
REMARK 465 SER G 280
REMARK 465 PRO G 281
REMARK 465 SER G 282
REMARK 465 PHE G 283
REMARK 465 LYS G 467
REMARK 465 GLN G 468
REMARK 465 SER G 469
REMARK 465 GLY G 470
REMARK 465 SER G 471
REMARK 465 LEU G 472
REMARK 465 PRO G 473
REMARK 465 LEU G 474
REMARK 465 SER G 475
REMARK 465 SER G 476
REMARK 465 LEU G 477
REMARK 465 THR G 478
REMARK 465 HIS G 479
REMARK 465 VAL G 480
REMARK 465 LEU G 481
REMARK 465 ARG G 482
REMARK 465 SER G 483
REMARK 465 LEU G 484
REMARK 465 THR G 485
REMARK 465 PRO G 486
REMARK 465 ASN G 487
REMARK 465 ALA G 488
REMARK 465 ARG G 489
REMARK 465 GLY G 490
REMARK 465 ILE G 491
REMARK 465 PHE G 492
REMARK 465 ARG G 493
REMARK 465 LEU G 494
REMARK 465 LEU G 495
REMARK 465 ILE G 496
REMARK 465 LYS G 497
REMARK 465 TYR G 498
REMARK 465 GLN G 499
REMARK 465 LEU G 500
REMARK 465 ASP G 501
REMARK 465 ASN G 502
REMARK 465 GLN G 503
REMARK 465 ASP G 504
REMARK 465 ASN G 505
REMARK 465 PRO G 506
REMARK 465 SER G 507
REMARK 465 TYR G 508
REMARK 465 ILE G 509
REMARK 465 GLY G 510
REMARK 465 LEU G 511
REMARK 465 SER G 512
REMARK 465 PHE G 513
REMARK 465 GLN G 514
REMARK 465 ASP G 515
REMARK 465 PHE G 516
REMARK 465 TYR G 517
REMARK 465 GLN G 518
REMARK 465 GLN G 519
REMARK 465 CYS G 520
REMARK 465 ARG G 521
REMARK 465 GLU G 522
REMARK 465 ALA G 523
REMARK 465 PHE G 524
REMARK 465 LEU G 525
REMARK 465 VAL G 526
REMARK 465 ASN G 527
REMARK 465 SER G 528
REMARK 465 ASP G 529
REMARK 465 LEU G 530
REMARK 465 THR G 531
REMARK 465 LEU G 532
REMARK 465 ARG G 533
REMARK 465 ALA G 534
REMARK 465 GLN G 535
REMARK 465 LEU G 536
REMARK 465 THR G 537
REMARK 465 GLU G 538
REMARK 465 PHE G 539
REMARK 465 ARG G 540
REMARK 465 ASP G 541
REMARK 465 HIS G 542
REMARK 465 LYS G 543
REMARK 465 LEU G 544
REMARK 465 ILE G 545
REMARK 465 ARG G 546
REMARK 465 THR G 547
REMARK 465 LYS G 548
REMARK 465 LYS G 549
REMARK 465 GLY G 550
REMARK 465 THR G 551
REMARK 465 ASP G 552
REMARK 465 GLY G 553
REMARK 465 VAL G 554
REMARK 465 GLU G 555
REMARK 465 TYR G 556
REMARK 465 LEU G 557
REMARK 465 LEU G 558
REMARK 465 ILE G 559
REMARK 465 PRO G 560
REMARK 465 VAL G 561
REMARK 465 ASP G 562
REMARK 465 ASN G 563
REMARK 465 GLY G 564
REMARK 465 THR G 565
REMARK 465 LEU G 566
REMARK 465 THR G 567
REMARK 465 ASP G 568
REMARK 465 PHE G 569
REMARK 465 LEU G 570
REMARK 465 GLU G 571
REMARK 465 LYS G 572
REMARK 465 GLU G 573
REMARK 465 GLU G 574
REMARK 465 GLU G 575
REMARK 465 GLU G 576
REMARK 465 ALA G 577
REMARK 465 MET H 231
REMARK 465 LYS H 232
REMARK 465 ARG H 233
REMARK 465 ASP H 234
REMARK 465 LYS H 235
REMARK 465 THR H 236
REMARK 465 SER H 237
REMARK 465 ASP H 238
REMARK 465 LEU H 239
REMARK 465 VAL H 240
REMARK 465 GLU H 241
REMARK 465 GLU H 242
REMARK 465 TYR H 243
REMARK 465 PHE H 244
REMARK 465 GLU H 245
REMARK 465 ALA H 246
REMARK 465 HIS H 247
REMARK 465 SER H 248
REMARK 465 SER H 249
REMARK 465 SER H 250
REMARK 465 LYS H 251
REMARK 465 VAL H 252
REMARK 465 LEU H 253
REMARK 465 THR H 254
REMARK 465 SER H 255
REMARK 465 ASP H 256
REMARK 465 ARG H 257
REMARK 465 THR H 258
REMARK 465 LEU H 259
REMARK 465 GLN H 260
REMARK 465 LYS H 261
REMARK 465 LEU H 262
REMARK 465 LYS H 263
REMARK 465 ARG H 264
REMARK 465 ALA H 265
REMARK 465 LYS H 266
REMARK 465 LEU H 267
REMARK 465 ASP H 268
REMARK 465 GLN H 269
REMARK 465 GLN H 270
REMARK 465 THR H 271
REMARK 465 LEU H 272
REMARK 465 ARG H 273
REMARK 465 ASN H 274
REMARK 465 LEU H 275
REMARK 465 LEU H 276
REMARK 465 SER H 277
REMARK 465 LYS H 278
REMARK 465 VAL H 279
REMARK 465 SER H 280
REMARK 465 PRO H 281
REMARK 465 SER H 282
REMARK 465 PHE H 283
REMARK 465 LYS H 467
REMARK 465 GLN H 468
REMARK 465 SER H 469
REMARK 465 GLY H 470
REMARK 465 SER H 471
REMARK 465 LEU H 472
REMARK 465 PRO H 473
REMARK 465 LEU H 474
REMARK 465 SER H 475
REMARK 465 SER H 476
REMARK 465 LEU H 477
REMARK 465 THR H 478
REMARK 465 HIS H 479
REMARK 465 VAL H 480
REMARK 465 LEU H 481
REMARK 465 ARG H 482
REMARK 465 SER H 483
REMARK 465 LEU H 484
REMARK 465 THR H 485
REMARK 465 PRO H 486
REMARK 465 ASN H 487
REMARK 465 ALA H 488
REMARK 465 ARG H 489
REMARK 465 GLY H 490
REMARK 465 ILE H 491
REMARK 465 PHE H 492
REMARK 465 ARG H 493
REMARK 465 LEU H 494
REMARK 465 LEU H 495
REMARK 465 ILE H 496
REMARK 465 LYS H 497
REMARK 465 TYR H 498
REMARK 465 GLN H 499
REMARK 465 LEU H 500
REMARK 465 ASP H 501
REMARK 465 ASN H 502
REMARK 465 GLN H 503
REMARK 465 ASP H 504
REMARK 465 ASN H 505
REMARK 465 PRO H 506
REMARK 465 SER H 507
REMARK 465 TYR H 508
REMARK 465 ILE H 509
REMARK 465 GLY H 510
REMARK 465 LEU H 511
REMARK 465 SER H 512
REMARK 465 PHE H 513
REMARK 465 GLN H 514
REMARK 465 ASP H 515
REMARK 465 PHE H 516
REMARK 465 TYR H 517
REMARK 465 GLN H 518
REMARK 465 GLN H 519
REMARK 465 CYS H 520
REMARK 465 ARG H 521
REMARK 465 GLU H 522
REMARK 465 ALA H 523
REMARK 465 PHE H 524
REMARK 465 LEU H 525
REMARK 465 VAL H 526
REMARK 465 ASN H 527
REMARK 465 SER H 528
REMARK 465 ASP H 529
REMARK 465 LEU H 530
REMARK 465 THR H 531
REMARK 465 LEU H 532
REMARK 465 ARG H 533
REMARK 465 ALA H 534
REMARK 465 GLN H 535
REMARK 465 LEU H 536
REMARK 465 THR H 537
REMARK 465 GLU H 538
REMARK 465 PHE H 539
REMARK 465 ARG H 540
REMARK 465 ASP H 541
REMARK 465 HIS H 542
REMARK 465 LYS H 543
REMARK 465 LEU H 544
REMARK 465 ILE H 545
REMARK 465 ARG H 546
REMARK 465 THR H 547
REMARK 465 LYS H 548
REMARK 465 LYS H 549
REMARK 465 GLY H 550
REMARK 465 THR H 551
REMARK 465 ASP H 552
REMARK 465 GLY H 553
REMARK 465 VAL H 554
REMARK 465 GLU H 555
REMARK 465 TYR H 556
REMARK 465 LEU H 557
REMARK 465 LEU H 558
REMARK 465 ILE H 559
REMARK 465 PRO H 560
REMARK 465 VAL H 561
REMARK 465 ASP H 562
REMARK 465 ASN H 563
REMARK 465 GLY H 564
REMARK 465 THR H 565
REMARK 465 LEU H 566
REMARK 465 THR H 567
REMARK 465 ASP H 568
REMARK 465 PHE H 569
REMARK 465 LEU H 570
REMARK 465 GLU H 571
REMARK 465 LYS H 572
REMARK 465 GLU H 573
REMARK 465 GLU H 574
REMARK 465 GLU H 575
REMARK 465 GLU H 576
REMARK 465 ALA H 577
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE
REMARK 500 CZ PHE C 244 CD2 LEU C 246 1.66
REMARK 500 NZ LYS C 202 CE1 PHE C 244 1.73
REMARK 500 O SER C 381 N GLN C 384 1.77
REMARK 500 O SER C 381 N LYS C 383 1.84
REMARK 500 O SER D 381 N GLN D 384 1.84
REMARK 500 CE2 PHE C 244 CD2 LEU C 246 1.87
REMARK 500 OH TYR B 375 OE1 GLU B 397 1.88
REMARK 500 O SER D 381 N LYS D 383 1.89
REMARK 500 O SER D 201 OG1 THR D 205 1.90
REMARK 500 OH TYR A 375 OE1 GLU A 397 1.90
REMARK 500 O SER B 201 OG1 THR B 205 1.92
REMARK 500 O LEU A 394 N GLU A 397 1.93
REMARK 500 O SER A 201 OG1 THR A 205 1.95
REMARK 500 OG1 THR A 112 OE1 GLN A 322 1.96
REMARK 500 O LEU B 394 N GLU B 397 1.98
REMARK 500 O LEU D 394 N GLU D 397 1.99
REMARK 500 O LEU C 394 N GLU C 397 1.99
REMARK 500 O SER C 201 OG1 THR C 205 1.99
REMARK 500 O SER E 318 OG SER E 452 2.00
REMARK 500 N LEU B 107 O ILE B 252 2.01
REMARK 500 O ASN A 645 N TRP A 649 2.01
REMARK 500 O SER G 347 N VAL G 351 2.02
REMARK 500 OG1 THR B 112 OE1 GLN B 322 2.03
REMARK 500 N GLY H 317 O THR H 450 2.03
REMARK 500 OD1 ASN B 303 OG SER B 583 2.03
REMARK 500 O ASN D 645 N TRP D 649 2.03
REMARK 500 O ASN C 645 N TRP C 649 2.03
REMARK 500 O ASN B 645 N TRP B 649 2.04
REMARK 500 N GLY F 317 O THR F 450 2.04
REMARK 500 N GLY G 317 O THR G 450 2.04
REMARK 500 O GLU A 687 N LEU A 691 2.05
REMARK 500 O LEU A 200 N ARG A 204 2.06
REMARK 500 O GLN A 52 OG SER A 56 2.06
REMARK 500 N GLY E 317 O THR E 450 2.07
REMARK 500 NH2 ARG B 43 O GLN B 339 2.07
REMARK 500 NZ LYS C 202 CD1 PHE C 244 2.07
REMARK 500 O LEU D 77 ND1 HIS D 81 2.08
REMARK 500 O SER G 318 OG SER G 452 2.08
REMARK 500 O SER E 347 N VAL E 351 2.08
REMARK 500 OG1 THR D 112 OE1 GLN D 322 2.08
REMARK 500 OH TYR C 47 OE1 GLN C 329 2.08
REMARK 500 N LEU A 107 O ILE A 252 2.09
REMARK 500 O LEU B 200 N ARG B 204 2.09
REMARK 500 O LEU A 77 ND1 HIS A 81 2.09
REMARK 500 O GLN B 52 OG SER B 56 2.10
REMARK 500 O LEU C 200 N ARG C 204 2.10
REMARK 500 O PHE C 372 N VAL C 376 2.10
REMARK 500 O PRO B 570 OG1 THR B 573 2.10
REMARK 500 O LYS E 319 N LEU E 323 2.10
REMARK 500 O GLN D 52 OG SER D 56 2.10
REMARK 500
REMARK 500 THIS ENTRY HAS 102 CLOSE CONTACTS
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION
REMARK 500 MET C 199 CG MET C 199 SD 0.996
REMARK 500 PHE C 244 CG PHE C 244 CD2 0.236
REMARK 500 PHE C 244 CG PHE C 244 CD1 0.212
REMARK 500 PHE C 244 CD1 PHE C 244 CE1 0.474
REMARK 500 PHE C 244 CE1 PHE C 244 CZ 0.546
REMARK 500 PHE C 244 CZ PHE C 244 CE2 0.517
REMARK 500 PHE C 244 CE2 PHE C 244 CD2 0.513
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3
REMARK 500 PRO A 131 C - N - CD ANGL. DEV. = -16.4 DEGREES
REMARK 500 LEU A 151 CA - CB - CG ANGL. DEV. = 23.4 DEGREES
REMARK 500 LEU A 241 CB - CG - CD1 ANGL. DEV. = -11.1 DEGREES
REMARK 500 LEU B 151 CA - CB - CG ANGL. DEV. = 23.4 DEGREES
REMARK 500 LEU B 241 CB - CG - CD1 ANGL. DEV. = -10.8 DEGREES
REMARK 500 LEU C 151 CA - CB - CG ANGL. DEV. = 24.7 DEGREES
REMARK 500 LEU C 151 CB - CG - CD1 ANGL. DEV. = 10.5 DEGREES
REMARK 500 LYS C 198 CD - CE - NZ ANGL. DEV. = 15.2 DEGREES
REMARK 500 MET C 199 CB - CG - SD ANGL. DEV. = 20.1 DEGREES
REMARK 500 MET C 199 CG - SD - CE ANGL. DEV. = 26.4 DEGREES
REMARK 500 LEU C 241 CB - CG - CD1 ANGL. DEV. = -10.9 DEGREES
REMARK 500 PHE C 244 CB - CG - CD1 ANGL. DEV. = -4.2 DEGREES
REMARK 500 LEU D 151 CA - CB - CG ANGL. DEV. = 24.0 DEGREES
REMARK 500 ARG E 320 NE - CZ - NH2 ANGL. DEV. = -5.0 DEGREES
REMARK 500 ARG F 320 NE - CZ - NH2 ANGL. DEV. = -5.0 DEGREES
REMARK 500 ARG G 320 NE - CZ - NH2 ANGL. DEV. = -4.9 DEGREES
REMARK 500 ARG H 320 NE - CZ - NH2 ANGL. DEV. = -5.1 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 TYR A 47 -73.93 -56.90
REMARK 500 ASN A 66 -71.95 -50.92
REMARK 500 VAL A 111 -72.61 -91.88
REMARK 500 VAL A 129 -13.80 82.00
REMARK 500 THR A 130 -148.04 -65.24
REMARK 500 PRO A 131 -174.81 -52.50
REMARK 500 CYS A 141 58.15 -142.65
REMARK 500 VAL A 160 -62.73 -103.09
REMARK 500 MET A 189 88.33 60.89
REMARK 500 THR A 190 -3.60 -47.73
REMARK 500 VAL A 191 -7.44 -58.22
REMARK 500 LYS A 203 -73.19 -105.52
REMARK 500 HIS A 242 -12.37 72.56
REMARK 500 PRO A 245 61.74 -66.87
REMARK 500 THR A 254 -169.39 -79.77
REMARK 500 LYS A 291 -73.83 -75.46
REMARK 500 LEU A 292 -72.28 -73.18
REMARK 500 HIS A 317 -77.87 -122.67
REMARK 500 CYS A 346 173.84 173.78
REMARK 500 ARG A 368 -60.43 -102.59
REMARK 500 SER A 371 -22.94 67.52
REMARK 500 LYS A 378 54.61 -94.34
REMARK 500 GLN A 379 -151.05 -115.66
REMARK 500 ALA A 380 -140.95 -142.82
REMARK 500 SER A 381 -126.44 -77.99
REMARK 500 GLU A 382 -70.13 -48.58
REMARK 500 LYS A 383 -54.72 -7.16
REMARK 500 THR A 389 -69.75 -98.41
REMARK 500 LEU A 394 -71.72 -70.01
REMARK 500 LYS A 428 -26.82 71.73
REMARK 500 TYR A 429 46.31 33.77
REMARK 500 ARG A 433 -73.34 -114.81
REMARK 500 ALA A 464 -146.77 52.33
REMARK 500 LYS A 465 -146.44 47.19
REMARK 500 THR A 490 0.44 80.31
REMARK 500 LYS A 492 -22.72 74.63
REMARK 500 PHE A 559 -72.65 -97.53
REMARK 500 CYS A 562 -74.66 -116.18
REMARK 500 LEU A 568 -178.49 -65.38
REMARK 500 LEU A 569 -179.28 -67.61
REMARK 500 VAL A 579 -25.35 76.25
REMARK 500 LEU A 592 -64.00 -133.85
REMARK 500 ALA A 594 73.58 57.32
REMARK 500 ALA A 595 70.82 -113.28
REMARK 500 CYS A 640 -83.56 -54.33
REMARK 500 SER A 641 -82.11 -144.05
REMARK 500 ARG A 642 -67.34 -136.72
REMARK 500 ASP A 702 70.54 58.12
REMARK 500 TYR B 47 -73.83 -56.87
REMARK 500 ASN B 66 -72.39 -50.96
REMARK 500
REMARK 500 THIS ENTRY HAS 216 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500 MODEL OMEGA
REMARK 500 THR A 130 PRO A 131 -147.97
REMARK 500 ASP A 140 CYS A 141 -139.35
REMARK 500 HIS A 240 LEU A 241 -149.80
REMARK 500 HIS A 242 GLU A 243 143.01
REMARK 500 GLU A 639 CYS A 640 -148.75
REMARK 500 ASP B 140 CYS B 141 -141.78
REMARK 500 MET B 189 THR B 190 -149.85
REMARK 500 HIS B 240 LEU B 241 -149.73
REMARK 500 HIS B 242 GLU B 243 144.42
REMARK 500 GLU B 639 CYS B 640 -149.51
REMARK 500 ASP C 140 CYS C 141 -138.45
REMARK 500 HIS C 242 GLU C 243 143.31
REMARK 500 GLU C 639 CYS C 640 -148.33
REMARK 500 ASP D 140 CYS D 141 -139.70
REMARK 500 HIS D 242 GLU D 243 138.84
REMARK 500 GLU D 639 CYS D 640 -148.67
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: 5UJ7 RELATED DB: PDB
DBREF 5UJ8 A 1 712 UNP Q9UBD5 ORC3_HUMAN 1 712
DBREF 5UJ8 B 1 712 UNP Q9UBD5 ORC3_HUMAN 1 712
DBREF 5UJ8 C 1 712 UNP Q9UBD5 ORC3_HUMAN 1 712
DBREF 5UJ8 D 1 712 UNP Q9UBD5 ORC3_HUMAN 1 712
DBREF 5UJ8 E 231 577 UNP Q13416 ORC2_HUMAN 231 577
DBREF 5UJ8 F 231 577 UNP Q13416 ORC2_HUMAN 231 577
DBREF 5UJ8 G 231 577 UNP Q13416 ORC2_HUMAN 231 577
DBREF 5UJ8 H 231 577 UNP Q13416 ORC2_HUMAN 231 577
SEQRES 1 A 712 MET ALA THR SER SER MET SER LYS GLY CYS PHE VAL PHE
SEQRES 2 A 712 LYS PRO ASN SER LYS LYS ARG LYS ILE SER LEU PRO ILE
SEQRES 3 A 712 GLU ASP TYR PHE ASN LYS GLY LYS ASN GLU PRO GLU ASP
SEQRES 4 A 712 SER LYS LEU ARG PHE GLU THR TYR GLN LEU ILE TRP GLN
SEQRES 5 A 712 GLN MET LYS SER GLU ASN GLU ARG LEU GLN GLU GLU LEU
SEQRES 6 A 712 ASN LYS ASN LEU PHE ASP ASN LEU ILE GLU PHE LEU GLN
SEQRES 7 A 712 LYS SER HIS SER GLY PHE GLN LYS ASN SER ARG ASP LEU
SEQRES 8 A 712 GLY GLY GLN ILE LYS LEU ARG GLU ILE PRO THR ALA ALA
SEQRES 9 A 712 LEU VAL LEU GLY VAL ASN VAL THR ASP HIS ASP LEU THR
SEQRES 10 A 712 PHE GLY SER LEU THR GLU ALA LEU GLN ASN ASN VAL THR
SEQRES 11 A 712 PRO TYR VAL VAL SER LEU GLN ALA LYS ASP CYS PRO ASP
SEQRES 12 A 712 MET LYS HIS PHE LEU GLN LYS LEU ILE SER GLN LEU MET
SEQRES 13 A 712 ASP CYS CYS VAL ASP ILE LYS SER LYS GLU GLU GLU SER
SEQRES 14 A 712 VAL HIS VAL THR GLN ARG LYS THR HIS TYR SER MET ASP
SEQRES 15 A 712 SER LEU SER SER TRP TYR MET THR VAL THR GLN LYS THR
SEQRES 16 A 712 ASP PRO LYS MET LEU SER LYS LYS ARG THR THR SER SER
SEQRES 17 A 712 GLN TRP GLN SER PRO PRO VAL VAL VAL ILE LEU LYS ASP
SEQRES 18 A 712 MET GLU SER PHE ALA THR LYS VAL LEU GLN ASP PHE ILE
SEQRES 19 A 712 ILE ILE SER SER GLN HIS LEU HIS GLU PHE PRO LEU ILE
SEQRES 20 A 712 LEU ILE PHE GLY ILE ALA THR SER PRO ILE ILE ILE HIS
SEQRES 21 A 712 ARG LEU LEU PRO HIS ALA VAL SER SER LEU LEU CYS ILE
SEQRES 22 A 712 GLU LEU PHE GLN SER LEU SER CYS LYS GLU HIS LEU THR
SEQRES 23 A 712 THR VAL LEU ASP LYS LEU LEU LEU THR THR GLN PHE PRO
SEQRES 24 A 712 PHE LYS ILE ASN GLU LYS VAL LEU GLN VAL LEU THR ASN
SEQRES 25 A 712 ILE PHE LEU TYR HIS ASP PHE SER VAL GLN ASN PHE ILE
SEQRES 26 A 712 LYS GLY LEU GLN LEU SER LEU LEU GLU HIS PHE TYR SER
SEQRES 27 A 712 GLN PRO LEU SER VAL LEU CYS CYS ASN LEU PRO GLU ALA
SEQRES 28 A 712 LYS ARG ARG ILE ASN PHE LEU SER ASN ASN GLN CYS GLU
SEQRES 29 A 712 ASN ILE ARG ARG LEU PRO SER PHE ARG ARG TYR VAL GLU
SEQRES 30 A 712 LYS GLN ALA SER GLU LYS GLN VAL ALA LEU LEU THR ASN
SEQRES 31 A 712 GLU ARG TYR LEU LYS GLU GLU THR GLN LEU LEU LEU GLU
SEQRES 32 A 712 ASN LEU HIS VAL TYR HIS MET ASN TYR PHE LEU VAL LEU
SEQRES 33 A 712 ARG CYS LEU HIS LYS PHE THR SER SER LEU PRO LYS TYR
SEQRES 34 A 712 PRO LEU GLY ARG GLN ILE ARG GLU LEU TYR CYS THR CYS
SEQRES 35 A 712 LEU GLU LYS ASN ILE TRP ASP SER GLU GLU TYR ALA SER
SEQRES 36 A 712 VAL LEU GLN LEU LEU ARG MET LEU ALA LYS ASP GLU LEU
SEQRES 37 A 712 MET THR ILE LEU GLU LYS CYS PHE LYS VAL PHE LYS SER
SEQRES 38 A 712 TYR CYS GLU ASN HIS LEU GLY SER THR ALA LYS ARG ILE
SEQRES 39 A 712 GLU GLU PHE LEU ALA GLN PHE GLN SER LEU ASP ALA GLU
SEQRES 40 A 712 THR LYS GLU GLU GLU ASP ALA SER GLY SER GLN PRO LYS
SEQRES 41 A 712 GLY LEU GLN LYS THR ASP LEU TYR HIS LEU GLN LYS SER
SEQRES 42 A 712 LEU LEU GLU MET LYS GLU LEU ARG ARG SER LYS LYS GLN
SEQRES 43 A 712 THR LYS PHE GLU VAL LEU ARG GLU ASN VAL VAL ASN PHE
SEQRES 44 A 712 ILE ASP CYS LEU VAL ARG GLU TYR LEU LEU PRO PRO GLU
SEQRES 45 A 712 THR GLN PRO LEU HIS GLU VAL VAL TYR PHE SER ALA ALA
SEQRES 46 A 712 HIS ALA LEU ARG GLU HIS LEU ASN ALA ALA PRO ARG ILE
SEQRES 47 A 712 ALA LEU HIS THR ALA LEU ASN ASN PRO TYR TYR TYR LEU
SEQRES 48 A 712 LYS ASN GLU ALA LEU LYS SER GLU GLU GLY CYS ILE PRO
SEQRES 49 A 712 ASN ILE ALA PRO ASP ILE CYS ILE ALA TYR LYS LEU HIS
SEQRES 50 A 712 LEU GLU CYS SER ARG LEU ILE ASN LEU VAL ASP TRP SER
SEQRES 51 A 712 GLU ALA PHE ALA THR VAL VAL THR ALA ALA GLU LYS MET
SEQRES 52 A 712 ASP ALA ASN SER ALA THR SER GLU GLU MET ASN GLU ILE
SEQRES 53 A 712 ILE HIS ALA ARG PHE ILE ARG ALA VAL SER GLU LEU GLU
SEQRES 54 A 712 LEU LEU GLY PHE ILE LYS PRO THR LYS GLN LYS THR ASP
SEQRES 55 A 712 HIS VAL ALA ARG LEU THR TRP GLY GLY CYS
SEQRES 1 B 712 MET ALA THR SER SER MET SER LYS GLY CYS PHE VAL PHE
SEQRES 2 B 712 LYS PRO ASN SER LYS LYS ARG LYS ILE SER LEU PRO ILE
SEQRES 3 B 712 GLU ASP TYR PHE ASN LYS GLY LYS ASN GLU PRO GLU ASP
SEQRES 4 B 712 SER LYS LEU ARG PHE GLU THR TYR GLN LEU ILE TRP GLN
SEQRES 5 B 712 GLN MET LYS SER GLU ASN GLU ARG LEU GLN GLU GLU LEU
SEQRES 6 B 712 ASN LYS ASN LEU PHE ASP ASN LEU ILE GLU PHE LEU GLN
SEQRES 7 B 712 LYS SER HIS SER GLY PHE GLN LYS ASN SER ARG ASP LEU
SEQRES 8 B 712 GLY GLY GLN ILE LYS LEU ARG GLU ILE PRO THR ALA ALA
SEQRES 9 B 712 LEU VAL LEU GLY VAL ASN VAL THR ASP HIS ASP LEU THR
SEQRES 10 B 712 PHE GLY SER LEU THR GLU ALA LEU GLN ASN ASN VAL THR
SEQRES 11 B 712 PRO TYR VAL VAL SER LEU GLN ALA LYS ASP CYS PRO ASP
SEQRES 12 B 712 MET LYS HIS PHE LEU GLN LYS LEU ILE SER GLN LEU MET
SEQRES 13 B 712 ASP CYS CYS VAL ASP ILE LYS SER LYS GLU GLU GLU SER
SEQRES 14 B 712 VAL HIS VAL THR GLN ARG LYS THR HIS TYR SER MET ASP
SEQRES 15 B 712 SER LEU SER SER TRP TYR MET THR VAL THR GLN LYS THR
SEQRES 16 B 712 ASP PRO LYS MET LEU SER LYS LYS ARG THR THR SER SER
SEQRES 17 B 712 GLN TRP GLN SER PRO PRO VAL VAL VAL ILE LEU LYS ASP
SEQRES 18 B 712 MET GLU SER PHE ALA THR LYS VAL LEU GLN ASP PHE ILE
SEQRES 19 B 712 ILE ILE SER SER GLN HIS LEU HIS GLU PHE PRO LEU ILE
SEQRES 20 B 712 LEU ILE PHE GLY ILE ALA THR SER PRO ILE ILE ILE HIS
SEQRES 21 B 712 ARG LEU LEU PRO HIS ALA VAL SER SER LEU LEU CYS ILE
SEQRES 22 B 712 GLU LEU PHE GLN SER LEU SER CYS LYS GLU HIS LEU THR
SEQRES 23 B 712 THR VAL LEU ASP LYS LEU LEU LEU THR THR GLN PHE PRO
SEQRES 24 B 712 PHE LYS ILE ASN GLU LYS VAL LEU GLN VAL LEU THR ASN
SEQRES 25 B 712 ILE PHE LEU TYR HIS ASP PHE SER VAL GLN ASN PHE ILE
SEQRES 26 B 712 LYS GLY LEU GLN LEU SER LEU LEU GLU HIS PHE TYR SER
SEQRES 27 B 712 GLN PRO LEU SER VAL LEU CYS CYS ASN LEU PRO GLU ALA
SEQRES 28 B 712 LYS ARG ARG ILE ASN PHE LEU SER ASN ASN GLN CYS GLU
SEQRES 29 B 712 ASN ILE ARG ARG LEU PRO SER PHE ARG ARG TYR VAL GLU
SEQRES 30 B 712 LYS GLN ALA SER GLU LYS GLN VAL ALA LEU LEU THR ASN
SEQRES 31 B 712 GLU ARG TYR LEU LYS GLU GLU THR GLN LEU LEU LEU GLU
SEQRES 32 B 712 ASN LEU HIS VAL TYR HIS MET ASN TYR PHE LEU VAL LEU
SEQRES 33 B 712 ARG CYS LEU HIS LYS PHE THR SER SER LEU PRO LYS TYR
SEQRES 34 B 712 PRO LEU GLY ARG GLN ILE ARG GLU LEU TYR CYS THR CYS
SEQRES 35 B 712 LEU GLU LYS ASN ILE TRP ASP SER GLU GLU TYR ALA SER
SEQRES 36 B 712 VAL LEU GLN LEU LEU ARG MET LEU ALA LYS ASP GLU LEU
SEQRES 37 B 712 MET THR ILE LEU GLU LYS CYS PHE LYS VAL PHE LYS SER
SEQRES 38 B 712 TYR CYS GLU ASN HIS LEU GLY SER THR ALA LYS ARG ILE
SEQRES 39 B 712 GLU GLU PHE LEU ALA GLN PHE GLN SER LEU ASP ALA GLU
SEQRES 40 B 712 THR LYS GLU GLU GLU ASP ALA SER GLY SER GLN PRO LYS
SEQRES 41 B 712 GLY LEU GLN LYS THR ASP LEU TYR HIS LEU GLN LYS SER
SEQRES 42 B 712 LEU LEU GLU MET LYS GLU LEU ARG ARG SER LYS LYS GLN
SEQRES 43 B 712 THR LYS PHE GLU VAL LEU ARG GLU ASN VAL VAL ASN PHE
SEQRES 44 B 712 ILE ASP CYS LEU VAL ARG GLU TYR LEU LEU PRO PRO GLU
SEQRES 45 B 712 THR GLN PRO LEU HIS GLU VAL VAL TYR PHE SER ALA ALA
SEQRES 46 B 712 HIS ALA LEU ARG GLU HIS LEU ASN ALA ALA PRO ARG ILE
SEQRES 47 B 712 ALA LEU HIS THR ALA LEU ASN ASN PRO TYR TYR TYR LEU
SEQRES 48 B 712 LYS ASN GLU ALA LEU LYS SER GLU GLU GLY CYS ILE PRO
SEQRES 49 B 712 ASN ILE ALA PRO ASP ILE CYS ILE ALA TYR LYS LEU HIS
SEQRES 50 B 712 LEU GLU CYS SER ARG LEU ILE ASN LEU VAL ASP TRP SER
SEQRES 51 B 712 GLU ALA PHE ALA THR VAL VAL THR ALA ALA GLU LYS MET
SEQRES 52 B 712 ASP ALA ASN SER ALA THR SER GLU GLU MET ASN GLU ILE
SEQRES 53 B 712 ILE HIS ALA ARG PHE ILE ARG ALA VAL SER GLU LEU GLU
SEQRES 54 B 712 LEU LEU GLY PHE ILE LYS PRO THR LYS GLN LYS THR ASP
SEQRES 55 B 712 HIS VAL ALA ARG LEU THR TRP GLY GLY CYS
SEQRES 1 C 712 MET ALA THR SER SER MET SER LYS GLY CYS PHE VAL PHE
SEQRES 2 C 712 LYS PRO ASN SER LYS LYS ARG LYS ILE SER LEU PRO ILE
SEQRES 3 C 712 GLU ASP TYR PHE ASN LYS GLY LYS ASN GLU PRO GLU ASP
SEQRES 4 C 712 SER LYS LEU ARG PHE GLU THR TYR GLN LEU ILE TRP GLN
SEQRES 5 C 712 GLN MET LYS SER GLU ASN GLU ARG LEU GLN GLU GLU LEU
SEQRES 6 C 712 ASN LYS ASN LEU PHE ASP ASN LEU ILE GLU PHE LEU GLN
SEQRES 7 C 712 LYS SER HIS SER GLY PHE GLN LYS ASN SER ARG ASP LEU
SEQRES 8 C 712 GLY GLY GLN ILE LYS LEU ARG GLU ILE PRO THR ALA ALA
SEQRES 9 C 712 LEU VAL LEU GLY VAL ASN VAL THR ASP HIS ASP LEU THR
SEQRES 10 C 712 PHE GLY SER LEU THR GLU ALA LEU GLN ASN ASN VAL THR
SEQRES 11 C 712 PRO TYR VAL VAL SER LEU GLN ALA LYS ASP CYS PRO ASP
SEQRES 12 C 712 MET LYS HIS PHE LEU GLN LYS LEU ILE SER GLN LEU MET
SEQRES 13 C 712 ASP CYS CYS VAL ASP ILE LYS SER LYS GLU GLU GLU SER
SEQRES 14 C 712 VAL HIS VAL THR GLN ARG LYS THR HIS TYR SER MET ASP
SEQRES 15 C 712 SER LEU SER SER TRP TYR MET THR VAL THR GLN LYS THR
SEQRES 16 C 712 ASP PRO LYS MET LEU SER LYS LYS ARG THR THR SER SER
SEQRES 17 C 712 GLN TRP GLN SER PRO PRO VAL VAL VAL ILE LEU LYS ASP
SEQRES 18 C 712 MET GLU SER PHE ALA THR LYS VAL LEU GLN ASP PHE ILE
SEQRES 19 C 712 ILE ILE SER SER GLN HIS LEU HIS GLU PHE PRO LEU ILE
SEQRES 20 C 712 LEU ILE PHE GLY ILE ALA THR SER PRO ILE ILE ILE HIS
SEQRES 21 C 712 ARG LEU LEU PRO HIS ALA VAL SER SER LEU LEU CYS ILE
SEQRES 22 C 712 GLU LEU PHE GLN SER LEU SER CYS LYS GLU HIS LEU THR
SEQRES 23 C 712 THR VAL LEU ASP LYS LEU LEU LEU THR THR GLN PHE PRO
SEQRES 24 C 712 PHE LYS ILE ASN GLU LYS VAL LEU GLN VAL LEU THR ASN
SEQRES 25 C 712 ILE PHE LEU TYR HIS ASP PHE SER VAL GLN ASN PHE ILE
SEQRES 26 C 712 LYS GLY LEU GLN LEU SER LEU LEU GLU HIS PHE TYR SER
SEQRES 27 C 712 GLN PRO LEU SER VAL LEU CYS CYS ASN LEU PRO GLU ALA
SEQRES 28 C 712 LYS ARG ARG ILE ASN PHE LEU SER ASN ASN GLN CYS GLU
SEQRES 29 C 712 ASN ILE ARG ARG LEU PRO SER PHE ARG ARG TYR VAL GLU
SEQRES 30 C 712 LYS GLN ALA SER GLU LYS GLN VAL ALA LEU LEU THR ASN
SEQRES 31 C 712 GLU ARG TYR LEU LYS GLU GLU THR GLN LEU LEU LEU GLU
SEQRES 32 C 712 ASN LEU HIS VAL TYR HIS MET ASN TYR PHE LEU VAL LEU
SEQRES 33 C 712 ARG CYS LEU HIS LYS PHE THR SER SER LEU PRO LYS TYR
SEQRES 34 C 712 PRO LEU GLY ARG GLN ILE ARG GLU LEU TYR CYS THR CYS
SEQRES 35 C 712 LEU GLU LYS ASN ILE TRP ASP SER GLU GLU TYR ALA SER
SEQRES 36 C 712 VAL LEU GLN LEU LEU ARG MET LEU ALA LYS ASP GLU LEU
SEQRES 37 C 712 MET THR ILE LEU GLU LYS CYS PHE LYS VAL PHE LYS SER
SEQRES 38 C 712 TYR CYS GLU ASN HIS LEU GLY SER THR ALA LYS ARG ILE
SEQRES 39 C 712 GLU GLU PHE LEU ALA GLN PHE GLN SER LEU ASP ALA GLU
SEQRES 40 C 712 THR LYS GLU GLU GLU ASP ALA SER GLY SER GLN PRO LYS
SEQRES 41 C 712 GLY LEU GLN LYS THR ASP LEU TYR HIS LEU GLN LYS SER
SEQRES 42 C 712 LEU LEU GLU MET LYS GLU LEU ARG ARG SER LYS LYS GLN
SEQRES 43 C 712 THR LYS PHE GLU VAL LEU ARG GLU ASN VAL VAL ASN PHE
SEQRES 44 C 712 ILE ASP CYS LEU VAL ARG GLU TYR LEU LEU PRO PRO GLU
SEQRES 45 C 712 THR GLN PRO LEU HIS GLU VAL VAL TYR PHE SER ALA ALA
SEQRES 46 C 712 HIS ALA LEU ARG GLU HIS LEU ASN ALA ALA PRO ARG ILE
SEQRES 47 C 712 ALA LEU HIS THR ALA LEU ASN ASN PRO TYR TYR TYR LEU
SEQRES 48 C 712 LYS ASN GLU ALA LEU LYS SER GLU GLU GLY CYS ILE PRO
SEQRES 49 C 712 ASN ILE ALA PRO ASP ILE CYS ILE ALA TYR LYS LEU HIS
SEQRES 50 C 712 LEU GLU CYS SER ARG LEU ILE ASN LEU VAL ASP TRP SER
SEQRES 51 C 712 GLU ALA PHE ALA THR VAL VAL THR ALA ALA GLU LYS MET
SEQRES 52 C 712 ASP ALA ASN SER ALA THR SER GLU GLU MET ASN GLU ILE
SEQRES 53 C 712 ILE HIS ALA ARG PHE ILE ARG ALA VAL SER GLU LEU GLU
SEQRES 54 C 712 LEU LEU GLY PHE ILE LYS PRO THR LYS GLN LYS THR ASP
SEQRES 55 C 712 HIS VAL ALA ARG LEU THR TRP GLY GLY CYS
SEQRES 1 D 712 MET ALA THR SER SER MET SER LYS GLY CYS PHE VAL PHE
SEQRES 2 D 712 LYS PRO ASN SER LYS LYS ARG LYS ILE SER LEU PRO ILE
SEQRES 3 D 712 GLU ASP TYR PHE ASN LYS GLY LYS ASN GLU PRO GLU ASP
SEQRES 4 D 712 SER LYS LEU ARG PHE GLU THR TYR GLN LEU ILE TRP GLN
SEQRES 5 D 712 GLN MET LYS SER GLU ASN GLU ARG LEU GLN GLU GLU LEU
SEQRES 6 D 712 ASN LYS ASN LEU PHE ASP ASN LEU ILE GLU PHE LEU GLN
SEQRES 7 D 712 LYS SER HIS SER GLY PHE GLN LYS ASN SER ARG ASP LEU
SEQRES 8 D 712 GLY GLY GLN ILE LYS LEU ARG GLU ILE PRO THR ALA ALA
SEQRES 9 D 712 LEU VAL LEU GLY VAL ASN VAL THR ASP HIS ASP LEU THR
SEQRES 10 D 712 PHE GLY SER LEU THR GLU ALA LEU GLN ASN ASN VAL THR
SEQRES 11 D 712 PRO TYR VAL VAL SER LEU GLN ALA LYS ASP CYS PRO ASP
SEQRES 12 D 712 MET LYS HIS PHE LEU GLN LYS LEU ILE SER GLN LEU MET
SEQRES 13 D 712 ASP CYS CYS VAL ASP ILE LYS SER LYS GLU GLU GLU SER
SEQRES 14 D 712 VAL HIS VAL THR GLN ARG LYS THR HIS TYR SER MET ASP
SEQRES 15 D 712 SER LEU SER SER TRP TYR MET THR VAL THR GLN LYS THR
SEQRES 16 D 712 ASP PRO LYS MET LEU SER LYS LYS ARG THR THR SER SER
SEQRES 17 D 712 GLN TRP GLN SER PRO PRO VAL VAL VAL ILE LEU LYS ASP
SEQRES 18 D 712 MET GLU SER PHE ALA THR LYS VAL LEU GLN ASP PHE ILE
SEQRES 19 D 712 ILE ILE SER SER GLN HIS LEU HIS GLU PHE PRO LEU ILE
SEQRES 20 D 712 LEU ILE PHE GLY ILE ALA THR SER PRO ILE ILE ILE HIS
SEQRES 21 D 712 ARG LEU LEU PRO HIS ALA VAL SER SER LEU LEU CYS ILE
SEQRES 22 D 712 GLU LEU PHE GLN SER LEU SER CYS LYS GLU HIS LEU THR
SEQRES 23 D 712 THR VAL LEU ASP LYS LEU LEU LEU THR THR GLN PHE PRO
SEQRES 24 D 712 PHE LYS ILE ASN GLU LYS VAL LEU GLN VAL LEU THR ASN
SEQRES 25 D 712 ILE PHE LEU TYR HIS ASP PHE SER VAL GLN ASN PHE ILE
SEQRES 26 D 712 LYS GLY LEU GLN LEU SER LEU LEU GLU HIS PHE TYR SER
SEQRES 27 D 712 GLN PRO LEU SER VAL LEU CYS CYS ASN LEU PRO GLU ALA
SEQRES 28 D 712 LYS ARG ARG ILE ASN PHE LEU SER ASN ASN GLN CYS GLU
SEQRES 29 D 712 ASN ILE ARG ARG LEU PRO SER PHE ARG ARG TYR VAL GLU
SEQRES 30 D 712 LYS GLN ALA SER GLU LYS GLN VAL ALA LEU LEU THR ASN
SEQRES 31 D 712 GLU ARG TYR LEU LYS GLU GLU THR GLN LEU LEU LEU GLU
SEQRES 32 D 712 ASN LEU HIS VAL TYR HIS MET ASN TYR PHE LEU VAL LEU
SEQRES 33 D 712 ARG CYS LEU HIS LYS PHE THR SER SER LEU PRO LYS TYR
SEQRES 34 D 712 PRO LEU GLY ARG GLN ILE ARG GLU LEU TYR CYS THR CYS
SEQRES 35 D 712 LEU GLU LYS ASN ILE TRP ASP SER GLU GLU TYR ALA SER
SEQRES 36 D 712 VAL LEU GLN LEU LEU ARG MET LEU ALA LYS ASP GLU LEU
SEQRES 37 D 712 MET THR ILE LEU GLU LYS CYS PHE LYS VAL PHE LYS SER
SEQRES 38 D 712 TYR CYS GLU ASN HIS LEU GLY SER THR ALA LYS ARG ILE
SEQRES 39 D 712 GLU GLU PHE LEU ALA GLN PHE GLN SER LEU ASP ALA GLU
SEQRES 40 D 712 THR LYS GLU GLU GLU ASP ALA SER GLY SER GLN PRO LYS
SEQRES 41 D 712 GLY LEU GLN LYS THR ASP LEU TYR HIS LEU GLN LYS SER
SEQRES 42 D 712 LEU LEU GLU MET LYS GLU LEU ARG ARG SER LYS LYS GLN
SEQRES 43 D 712 THR LYS PHE GLU VAL LEU ARG GLU ASN VAL VAL ASN PHE
SEQRES 44 D 712 ILE ASP CYS LEU VAL ARG GLU TYR LEU LEU PRO PRO GLU
SEQRES 45 D 712 THR GLN PRO LEU HIS GLU VAL VAL TYR PHE SER ALA ALA
SEQRES 46 D 712 HIS ALA LEU ARG GLU HIS LEU ASN ALA ALA PRO ARG ILE
SEQRES 47 D 712 ALA LEU HIS THR ALA LEU ASN ASN PRO TYR TYR TYR LEU
SEQRES 48 D 712 LYS ASN GLU ALA LEU LYS SER GLU GLU GLY CYS ILE PRO
SEQRES 49 D 712 ASN ILE ALA PRO ASP ILE CYS ILE ALA TYR LYS LEU HIS
SEQRES 50 D 712 LEU GLU CYS SER ARG LEU ILE ASN LEU VAL ASP TRP SER
SEQRES 51 D 712 GLU ALA PHE ALA THR VAL VAL THR ALA ALA GLU LYS MET
SEQRES 52 D 712 ASP ALA ASN SER ALA THR SER GLU GLU MET ASN GLU ILE
SEQRES 53 D 712 ILE HIS ALA ARG PHE ILE ARG ALA VAL SER GLU LEU GLU
SEQRES 54 D 712 LEU LEU GLY PHE ILE LYS PRO THR LYS GLN LYS THR ASP
SEQRES 55 D 712 HIS VAL ALA ARG LEU THR TRP GLY GLY CYS
SEQRES 1 E 347 MET LYS ARG ASP LYS THR SER ASP LEU VAL GLU GLU TYR
SEQRES 2 E 347 PHE GLU ALA HIS SER SER SER LYS VAL LEU THR SER ASP
SEQRES 3 E 347 ARG THR LEU GLN LYS LEU LYS ARG ALA LYS LEU ASP GLN
SEQRES 4 E 347 GLN THR LEU ARG ASN LEU LEU SER LYS VAL SER PRO SER
SEQRES 5 E 347 PHE SER ALA GLU LEU LYS GLN LEU ASN GLN GLN TYR GLU
SEQRES 6 E 347 LYS LEU PHE HIS LYS TRP MET LEU GLN LEU HIS LEU GLY
SEQRES 7 E 347 PHE ASN ILE VAL LEU TYR GLY LEU GLY SER LYS ARG ASP
SEQRES 8 E 347 LEU LEU GLU ARG PHE ARG THR THR MET LEU GLN ASP SER
SEQRES 9 E 347 ILE HIS VAL VAL ILE ASN GLY PHE PHE PRO GLY ILE SER
SEQRES 10 E 347 VAL LYS SER VAL LEU ASN SER ILE THR GLU GLU VAL LEU
SEQRES 11 E 347 ASP HIS MET GLY THR PHE ARG SER ILE LEU ASP GLN LEU
SEQRES 12 E 347 ASP TRP ILE VAL ASN LYS PHE LYS GLU ASP SER SER LEU
SEQRES 13 E 347 GLU LEU PHE LEU LEU ILE HIS ASN LEU ASP SER GLN MET
SEQRES 14 E 347 LEU ARG GLY GLU LYS SER GLN GLN ILE ILE GLY GLN LEU
SEQRES 15 E 347 SER SER LEU HIS ASN ILE TYR LEU ILE ALA SER ILE ASP
SEQRES 16 E 347 HIS LEU ASN ALA PRO LEU MET TRP ASP HIS ALA LYS GLN
SEQRES 17 E 347 SER LEU PHE ASN TRP LEU TRP TYR GLU THR THR THR TYR
SEQRES 18 E 347 SER PRO TYR THR GLU GLU THR SER TYR GLU ASN SER LEU
SEQRES 19 E 347 LEU VAL LYS GLN SER GLY SER LEU PRO LEU SER SER LEU
SEQRES 20 E 347 THR HIS VAL LEU ARG SER LEU THR PRO ASN ALA ARG GLY
SEQRES 21 E 347 ILE PHE ARG LEU LEU ILE LYS TYR GLN LEU ASP ASN GLN
SEQRES 22 E 347 ASP ASN PRO SER TYR ILE GLY LEU SER PHE GLN ASP PHE
SEQRES 23 E 347 TYR GLN GLN CYS ARG GLU ALA PHE LEU VAL ASN SER ASP
SEQRES 24 E 347 LEU THR LEU ARG ALA GLN LEU THR GLU PHE ARG ASP HIS
SEQRES 25 E 347 LYS LEU ILE ARG THR LYS LYS GLY THR ASP GLY VAL GLU
SEQRES 26 E 347 TYR LEU LEU ILE PRO VAL ASP ASN GLY THR LEU THR ASP
SEQRES 27 E 347 PHE LEU GLU LYS GLU GLU GLU GLU ALA
SEQRES 1 F 347 MET LYS ARG ASP LYS THR SER ASP LEU VAL GLU GLU TYR
SEQRES 2 F 347 PHE GLU ALA HIS SER SER SER LYS VAL LEU THR SER ASP
SEQRES 3 F 347 ARG THR LEU GLN LYS LEU LYS ARG ALA LYS LEU ASP GLN
SEQRES 4 F 347 GLN THR LEU ARG ASN LEU LEU SER LYS VAL SER PRO SER
SEQRES 5 F 347 PHE SER ALA GLU LEU LYS GLN LEU ASN GLN GLN TYR GLU
SEQRES 6 F 347 LYS LEU PHE HIS LYS TRP MET LEU GLN LEU HIS LEU GLY
SEQRES 7 F 347 PHE ASN ILE VAL LEU TYR GLY LEU GLY SER LYS ARG ASP
SEQRES 8 F 347 LEU LEU GLU ARG PHE ARG THR THR MET LEU GLN ASP SER
SEQRES 9 F 347 ILE HIS VAL VAL ILE ASN GLY PHE PHE PRO GLY ILE SER
SEQRES 10 F 347 VAL LYS SER VAL LEU ASN SER ILE THR GLU GLU VAL LEU
SEQRES 11 F 347 ASP HIS MET GLY THR PHE ARG SER ILE LEU ASP GLN LEU
SEQRES 12 F 347 ASP TRP ILE VAL ASN LYS PHE LYS GLU ASP SER SER LEU
SEQRES 13 F 347 GLU LEU PHE LEU LEU ILE HIS ASN LEU ASP SER GLN MET
SEQRES 14 F 347 LEU ARG GLY GLU LYS SER GLN GLN ILE ILE GLY GLN LEU
SEQRES 15 F 347 SER SER LEU HIS ASN ILE TYR LEU ILE ALA SER ILE ASP
SEQRES 16 F 347 HIS LEU ASN ALA PRO LEU MET TRP ASP HIS ALA LYS GLN
SEQRES 17 F 347 SER LEU PHE ASN TRP LEU TRP TYR GLU THR THR THR TYR
SEQRES 18 F 347 SER PRO TYR THR GLU GLU THR SER TYR GLU ASN SER LEU
SEQRES 19 F 347 LEU VAL LYS GLN SER GLY SER LEU PRO LEU SER SER LEU
SEQRES 20 F 347 THR HIS VAL LEU ARG SER LEU THR PRO ASN ALA ARG GLY
SEQRES 21 F 347 ILE PHE ARG LEU LEU ILE LYS TYR GLN LEU ASP ASN GLN
SEQRES 22 F 347 ASP ASN PRO SER TYR ILE GLY LEU SER PHE GLN ASP PHE
SEQRES 23 F 347 TYR GLN GLN CYS ARG GLU ALA PHE LEU VAL ASN SER ASP
SEQRES 24 F 347 LEU THR LEU ARG ALA GLN LEU THR GLU PHE ARG ASP HIS
SEQRES 25 F 347 LYS LEU ILE ARG THR LYS LYS GLY THR ASP GLY VAL GLU
SEQRES 26 F 347 TYR LEU LEU ILE PRO VAL ASP ASN GLY THR LEU THR ASP
SEQRES 27 F 347 PHE LEU GLU LYS GLU GLU GLU GLU ALA
SEQRES 1 G 347 MET LYS ARG ASP LYS THR SER ASP LEU VAL GLU GLU TYR
SEQRES 2 G 347 PHE GLU ALA HIS SER SER SER LYS VAL LEU THR SER ASP
SEQRES 3 G 347 ARG THR LEU GLN LYS LEU LYS ARG ALA LYS LEU ASP GLN
SEQRES 4 G 347 GLN THR LEU ARG ASN LEU LEU SER LYS VAL SER PRO SER
SEQRES 5 G 347 PHE SER ALA GLU LEU LYS GLN LEU ASN GLN GLN TYR GLU
SEQRES 6 G 347 LYS LEU PHE HIS LYS TRP MET LEU GLN LEU HIS LEU GLY
SEQRES 7 G 347 PHE ASN ILE VAL LEU TYR GLY LEU GLY SER LYS ARG ASP
SEQRES 8 G 347 LEU LEU GLU ARG PHE ARG THR THR MET LEU GLN ASP SER
SEQRES 9 G 347 ILE HIS VAL VAL ILE ASN GLY PHE PHE PRO GLY ILE SER
SEQRES 10 G 347 VAL LYS SER VAL LEU ASN SER ILE THR GLU GLU VAL LEU
SEQRES 11 G 347 ASP HIS MET GLY THR PHE ARG SER ILE LEU ASP GLN LEU
SEQRES 12 G 347 ASP TRP ILE VAL ASN LYS PHE LYS GLU ASP SER SER LEU
SEQRES 13 G 347 GLU LEU PHE LEU LEU ILE HIS ASN LEU ASP SER GLN MET
SEQRES 14 G 347 LEU ARG GLY GLU LYS SER GLN GLN ILE ILE GLY GLN LEU
SEQRES 15 G 347 SER SER LEU HIS ASN ILE TYR LEU ILE ALA SER ILE ASP
SEQRES 16 G 347 HIS LEU ASN ALA PRO LEU MET TRP ASP HIS ALA LYS GLN
SEQRES 17 G 347 SER LEU PHE ASN TRP LEU TRP TYR GLU THR THR THR TYR
SEQRES 18 G 347 SER PRO TYR THR GLU GLU THR SER TYR GLU ASN SER LEU
SEQRES 19 G 347 LEU VAL LYS GLN SER GLY SER LEU PRO LEU SER SER LEU
SEQRES 20 G 347 THR HIS VAL LEU ARG SER LEU THR PRO ASN ALA ARG GLY
SEQRES 21 G 347 ILE PHE ARG LEU LEU ILE LYS TYR GLN LEU ASP ASN GLN
SEQRES 22 G 347 ASP ASN PRO SER TYR ILE GLY LEU SER PHE GLN ASP PHE
SEQRES 23 G 347 TYR GLN GLN CYS ARG GLU ALA PHE LEU VAL ASN SER ASP
SEQRES 24 G 347 LEU THR LEU ARG ALA GLN LEU THR GLU PHE ARG ASP HIS
SEQRES 25 G 347 LYS LEU ILE ARG THR LYS LYS GLY THR ASP GLY VAL GLU
SEQRES 26 G 347 TYR LEU LEU ILE PRO VAL ASP ASN GLY THR LEU THR ASP
SEQRES 27 G 347 PHE LEU GLU LYS GLU GLU GLU GLU ALA
SEQRES 1 H 347 MET LYS ARG ASP LYS THR SER ASP LEU VAL GLU GLU TYR
SEQRES 2 H 347 PHE GLU ALA HIS SER SER SER LYS VAL LEU THR SER ASP
SEQRES 3 H 347 ARG THR LEU GLN LYS LEU LYS ARG ALA LYS LEU ASP GLN
SEQRES 4 H 347 GLN THR LEU ARG ASN LEU LEU SER LYS VAL SER PRO SER
SEQRES 5 H 347 PHE SER ALA GLU LEU LYS GLN LEU ASN GLN GLN TYR GLU
SEQRES 6 H 347 LYS LEU PHE HIS LYS TRP MET LEU GLN LEU HIS LEU GLY
SEQRES 7 H 347 PHE ASN ILE VAL LEU TYR GLY LEU GLY SER LYS ARG ASP
SEQRES 8 H 347 LEU LEU GLU ARG PHE ARG THR THR MET LEU GLN ASP SER
SEQRES 9 H 347 ILE HIS VAL VAL ILE ASN GLY PHE PHE PRO GLY ILE SER
SEQRES 10 H 347 VAL LYS SER VAL LEU ASN SER ILE THR GLU GLU VAL LEU
SEQRES 11 H 347 ASP HIS MET GLY THR PHE ARG SER ILE LEU ASP GLN LEU
SEQRES 12 H 347 ASP TRP ILE VAL ASN LYS PHE LYS GLU ASP SER SER LEU
SEQRES 13 H 347 GLU LEU PHE LEU LEU ILE HIS ASN LEU ASP SER GLN MET
SEQRES 14 H 347 LEU ARG GLY GLU LYS SER GLN GLN ILE ILE GLY GLN LEU
SEQRES 15 H 347 SER SER LEU HIS ASN ILE TYR LEU ILE ALA SER ILE ASP
SEQRES 16 H 347 HIS LEU ASN ALA PRO LEU MET TRP ASP HIS ALA LYS GLN
SEQRES 17 H 347 SER LEU PHE ASN TRP LEU TRP TYR GLU THR THR THR TYR
SEQRES 18 H 347 SER PRO TYR THR GLU GLU THR SER TYR GLU ASN SER LEU
SEQRES 19 H 347 LEU VAL LYS GLN SER GLY SER LEU PRO LEU SER SER LEU
SEQRES 20 H 347 THR HIS VAL LEU ARG SER LEU THR PRO ASN ALA ARG GLY
SEQRES 21 H 347 ILE PHE ARG LEU LEU ILE LYS TYR GLN LEU ASP ASN GLN
SEQRES 22 H 347 ASP ASN PRO SER TYR ILE GLY LEU SER PHE GLN ASP PHE
SEQRES 23 H 347 TYR GLN GLN CYS ARG GLU ALA PHE LEU VAL ASN SER ASP
SEQRES 24 H 347 LEU THR LEU ARG ALA GLN LEU THR GLU PHE ARG ASP HIS
SEQRES 25 H 347 LYS LEU ILE ARG THR LYS LYS GLY THR ASP GLY VAL GLU
SEQRES 26 H 347 TYR LEU LEU ILE PRO VAL ASP ASN GLY THR LEU THR ASP
SEQRES 27 H 347 PHE LEU GLU LYS GLU GLU GLU GLU ALA
HELIX 1 AA1 LYS A 41 HIS A 81 1 41
HELIX 2 AA2 VAL A 111 ASP A 113 5 3
HELIX 3 AA3 HIS A 114 ASN A 128 1 15
HELIX 4 AA4 MET A 144 CYS A 158 1 15
HELIX 5 AA5 VAL A 160 SER A 164 5 5
HELIX 6 AA6 MET A 189 GLN A 193 5 5
HELIX 7 AA7 ASP A 196 LYS A 202 1 7
HELIX 8 AA8 ALA A 226 HIS A 240 1 15
HELIX 9 AA9 SER A 255 LEU A 263 1 9
HELIX 10 AB1 PRO A 264 LEU A 271 1 8
HELIX 11 AB2 SER A 280 LEU A 292 1 13
HELIX 12 AB3 ASN A 303 TYR A 316 1 14
HELIX 13 AB4 SER A 320 TYR A 337 1 18
HELIX 14 AB5 SER A 338 CYS A 345 5 8
HELIX 15 AB6 ASN A 347 LEU A 358 1 12
HELIX 16 AB7 SER A 359 ARG A 367 1 9
HELIX 17 AB8 PHE A 372 LYS A 378 1 7
HELIX 18 AB9 SER A 381 LYS A 383 5 3
HELIX 19 AC1 GLN A 384 THR A 389 1 6
HELIX 20 AC2 ASN A 390 SER A 424 1 35
HELIX 21 AC3 GLN A 434 LYS A 445 1 12
HELIX 22 AC4 SER A 450 ALA A 464 1 15
HELIX 23 AC5 ALA A 464 ASN A 485 1 22
HELIX 24 AC6 LYS A 492 ALA A 506 1 15
HELIX 25 AC7 PHE A 549 ILE A 560 1 12
HELIX 26 AC8 ALA A 584 LEU A 592 1 9
HELIX 27 AC9 ALA A 595 ASN A 606 1 12
HELIX 28 AD1 ASP A 629 CYS A 640 1 12
HELIX 29 AD2 ASN A 645 GLU A 651 1 7
HELIX 30 AD3 GLU A 651 VAL A 657 1 7
HELIX 31 AD4 HIS A 678 LEU A 691 1 14
HELIX 32 AD5 LEU B 42 HIS B 81 1 40
HELIX 33 AD6 VAL B 111 ASP B 113 5 3
HELIX 34 AD7 HIS B 114 ASN B 128 1 15
HELIX 35 AD8 MET B 144 CYS B 158 1 15
HELIX 36 AD9 VAL B 160 SER B 164 5 5
HELIX 37 AE1 MET B 189 GLN B 193 5 5
HELIX 38 AE2 ASP B 196 LYS B 202 1 7
HELIX 39 AE3 ALA B 226 HIS B 240 1 15
HELIX 40 AE4 SER B 255 LEU B 263 1 9
HELIX 41 AE5 PRO B 264 LEU B 271 1 8
HELIX 42 AE6 SER B 280 LEU B 292 1 13
HELIX 43 AE7 ASN B 303 TYR B 316 1 14
HELIX 44 AE8 SER B 320 TYR B 337 1 18
HELIX 45 AE9 SER B 338 CYS B 345 5 8
HELIX 46 AF1 ASN B 347 LEU B 358 1 12
HELIX 47 AF2 SER B 359 ARG B 367 1 9
HELIX 48 AF3 PHE B 372 LYS B 378 1 7
HELIX 49 AF4 SER B 381 LYS B 383 5 3
HELIX 50 AF5 GLN B 384 THR B 389 1 6
HELIX 51 AF6 ASN B 390 SER B 424 1 35
HELIX 52 AF7 GLN B 434 LYS B 445 1 12
HELIX 53 AF8 SER B 450 ALA B 464 1 15
HELIX 54 AF9 ALA B 464 ASN B 485 1 22
HELIX 55 AG1 LYS B 492 ALA B 506 1 15
HELIX 56 AG2 GLU B 550 ILE B 560 1 11
HELIX 57 AG3 ALA B 584 LEU B 592 1 9
HELIX 58 AG4 ALA B 595 ASN B 606 1 12
HELIX 59 AG5 ASP B 629 CYS B 640 1 12
HELIX 60 AG6 ASN B 645 GLU B 651 1 7
HELIX 61 AG7 ALA B 652 VAL B 657 1 6
HELIX 62 AG8 HIS B 678 LEU B 691 1 14
HELIX 63 AG9 LEU C 42 HIS C 81 1 40
HELIX 64 AH1 VAL C 111 ASP C 113 5 3
HELIX 65 AH2 HIS C 114 ASN C 128 1 15
HELIX 66 AH3 MET C 144 CYS C 158 1 15
HELIX 67 AH4 VAL C 160 SER C 164 5 5
HELIX 68 AH5 MET C 189 GLN C 193 5 5
HELIX 69 AH6 ASP C 196 LYS C 202 1 7
HELIX 70 AH7 ALA C 226 HIS C 240 1 15
HELIX 71 AH8 SER C 255 LEU C 263 1 9
HELIX 72 AH9 PRO C 264 CYS C 272 1 9
HELIX 73 AI1 SER C 280 LEU C 292 1 13
HELIX 74 AI2 ASN C 303 TYR C 316 1 14
HELIX 75 AI3 SER C 320 TYR C 337 1 18
HELIX 76 AI4 SER C 338 CYS C 345 5 8
HELIX 77 AI5 ASN C 347 LEU C 358 1 12
HELIX 78 AI6 SER C 359 ARG C 367 1 9
HELIX 79 AI7 PHE C 372 LYS C 378 1 7
HELIX 80 AI8 GLN C 384 THR C 389 1 6
HELIX 81 AI9 ASN C 390 SER C 424 1 35
HELIX 82 AJ1 GLN C 434 LYS C 445 1 12
HELIX 83 AJ2 SER C 450 ALA C 464 1 15
HELIX 84 AJ3 ALA C 464 ASN C 485 1 22
HELIX 85 AJ4 LYS C 492 ALA C 506 1 15
HELIX 86 AJ5 GLU C 550 ILE C 560 1 11
HELIX 87 AJ6 ALA C 584 LEU C 592 1 9
HELIX 88 AJ7 ALA C 595 ASN C 606 1 12
HELIX 89 AJ8 ASP C 629 CYS C 640 1 12
HELIX 90 AJ9 ASN C 645 GLU C 651 1 7
HELIX 91 AK1 GLU C 651 VAL C 657 1 7
HELIX 92 AK2 HIS C 678 LEU C 691 1 14
HELIX 93 AK3 LEU D 42 HIS D 81 1 40
HELIX 94 AK4 VAL D 111 ASP D 113 5 3
HELIX 95 AK5 HIS D 114 ASN D 128 1 15
HELIX 96 AK6 MET D 144 CYS D 158 1 15
HELIX 97 AK7 VAL D 160 SER D 164 5 5
HELIX 98 AK8 ASP D 196 LYS D 202 1 7
HELIX 99 AK9 ALA D 226 HIS D 240 1 15
HELIX 100 AL1 SER D 255 LEU D 263 1 9
HELIX 101 AL2 PRO D 264 CYS D 272 1 9
HELIX 102 AL3 SER D 280 LEU D 292 1 13
HELIX 103 AL4 ASN D 303 TYR D 316 1 14
HELIX 104 AL5 SER D 320 TYR D 337 1 18
HELIX 105 AL6 SER D 338 CYS D 345 5 8
HELIX 106 AL7 ASN D 347 LEU D 358 1 12
HELIX 107 AL8 SER D 359 ARG D 367 1 9
HELIX 108 AL9 PHE D 372 LYS D 378 1 7
HELIX 109 AM1 SER D 381 THR D 389 1 9
HELIX 110 AM2 ASN D 390 SER D 424 1 35
HELIX 111 AM3 GLN D 434 LYS D 445 1 12
HELIX 112 AM4 SER D 450 ALA D 464 1 15
HELIX 113 AM5 ALA D 464 ASN D 485 1 22
HELIX 114 AM6 LYS D 492 ALA D 506 1 15
HELIX 115 AM7 GLU D 550 ILE D 560 1 11
HELIX 116 AM8 ALA D 584 LEU D 592 1 9
HELIX 117 AM9 ALA D 595 ASN D 606 1 12
HELIX 118 AN1 ASP D 629 CYS D 640 1 12
HELIX 119 AN2 ASN D 645 GLU D 651 1 7
HELIX 120 AN3 GLU D 651 VAL D 657 1 7
HELIX 121 AN4 HIS D 678 LEU D 691 1 14
HELIX 122 AN5 ALA E 285 GLY E 308 1 24
HELIX 123 AN6 LYS E 319 THR E 329 1 11
HELIX 124 AN7 SER E 347 GLU E 357 1 11
HELIX 125 AN8 SER E 368 LYS E 381 1 14
HELIX 126 AN9 GLY E 402 LEU E 415 1 14
HELIX 127 AO1 ASN E 428 TRP E 433 1 6
HELIX 128 AO2 ASP E 434 PHE E 441 1 8
HELIX 129 AO3 ALA F 285 GLY F 308 1 24
HELIX 130 AO4 LYS F 319 THR F 329 1 11
HELIX 131 AO5 SER F 347 GLU F 358 1 12
HELIX 132 AO6 SER F 368 LYS F 381 1 14
HELIX 133 AO7 LYS F 404 LEU F 415 1 12
HELIX 134 AO8 ASN F 428 TRP F 433 1 6
HELIX 135 AO9 ASP F 434 PHE F 441 1 8
HELIX 136 AP1 ALA G 285 GLY G 308 1 24
HELIX 137 AP2 LYS G 319 THR G 329 1 11
HELIX 138 AP3 SER G 347 GLU G 358 1 12
HELIX 139 AP4 SER G 368 LYS G 381 1 14
HELIX 140 AP5 LYS G 404 LEU G 415 1 12
HELIX 141 AP6 ASN G 428 TRP G 433 1 6
HELIX 142 AP7 ASP G 434 PHE G 441 1 8
HELIX 143 AP8 GLU H 286 GLY H 308 1 23
HELIX 144 AP9 LYS H 319 THR H 329 1 11
HELIX 145 AQ1 SER H 347 GLU H 358 1 12
HELIX 146 AQ2 SER H 368 LYS H 381 1 14
HELIX 147 AQ3 LYS H 404 LEU H 415 1 12
HELIX 148 AQ4 ASN H 428 TRP H 433 1 6
HELIX 149 AQ5 ASP H 434 PHE H 441 1 8
SHEET 1 AA1 3 ILE A 249 PHE A 250 0
SHEET 2 AA1 3 ALA A 103 ALA A 104 1 N ALA A 103 O PHE A 250
SHEET 3 AA1 3 GLU A 274 LEU A 275 1 O GLU A 274 N ALA A 104
SHEET 1 AA2 2 VAL A 134 LEU A 136 0
SHEET 2 AA2 2 VAL A 217 LEU A 219 1 O ILE A 218 N VAL A 134
SHEET 1 AA3 2 LYS A 301 ILE A 302 0
SHEET 2 AA3 2 TYR A 581 PHE A 582 1 O PHE A 582 N LYS A 301
SHEET 1 AA4 2 PRO A 696 THR A 697 0
SHEET 2 AA4 2 HIS A 703 VAL A 704 -1 O HIS A 703 N THR A 697
SHEET 1 AA5 2 ALA B 103 ALA B 104 0
SHEET 2 AA5 2 ILE B 249 PHE B 250 1 O PHE B 250 N ALA B 103
SHEET 1 AA6 2 VAL B 134 LEU B 136 0
SHEET 2 AA6 2 VAL B 217 LEU B 219 1 O ILE B 218 N VAL B 134
SHEET 1 AA7 2 LYS B 301 ILE B 302 0
SHEET 2 AA7 2 TYR B 581 PHE B 582 1 O PHE B 582 N LYS B 301
SHEET 1 AA8 2 PRO B 696 THR B 697 0
SHEET 2 AA8 2 HIS B 703 VAL B 704 -1 O HIS B 703 N THR B 697
SHEET 1 AA9 3 ILE C 249 PHE C 250 0
SHEET 2 AA9 3 ALA C 103 ALA C 104 1 N ALA C 103 O PHE C 250
SHEET 3 AA9 3 GLU C 274 LEU C 275 1 O GLU C 274 N ALA C 104
SHEET 1 AB1 2 VAL C 134 LEU C 136 0
SHEET 2 AB1 2 VAL C 217 LEU C 219 1 O ILE C 218 N VAL C 134
SHEET 1 AB2 2 LYS C 301 ILE C 302 0
SHEET 2 AB2 2 TYR C 581 PHE C 582 1 O PHE C 582 N LYS C 301
SHEET 1 AB3 2 PRO C 696 THR C 697 0
SHEET 2 AB3 2 HIS C 703 VAL C 704 -1 N HIS C 703 O THR C 697
SHEET 1 AB4 3 ILE D 249 PHE D 250 0
SHEET 2 AB4 3 ALA D 103 ALA D 104 1 N ALA D 103 O PHE D 250
SHEET 3 AB4 3 GLU D 274 LEU D 275 1 O GLU D 274 N ALA D 104
SHEET 1 AB5 2 VAL D 134 LEU D 136 0
SHEET 2 AB5 2 VAL D 217 LEU D 219 1 O ILE D 218 N VAL D 134
SHEET 1 AB6 2 LYS D 301 ILE D 302 0
SHEET 2 AB6 2 TYR D 581 PHE D 582 1 O PHE D 582 N LYS D 301
SHEET 1 AB7 2 PRO D 696 THR D 697 0
SHEET 2 AB7 2 HIS D 703 VAL D 704 -1 O HIS D 703 N THR D 697
SHEET 1 AB8 5 HIS E 336 ASN E 340 0
SHEET 2 AB8 5 LEU E 388 HIS E 393 1 O LEU E 391 N VAL E 337
SHEET 3 AB8 5 ILE E 418 ILE E 424 1 O TYR E 419 N LEU E 390
SHEET 4 AB8 5 ASN E 310 TYR E 314 1 N LEU E 313 O ALA E 422
SHEET 5 AB8 5 TRP E 443 TYR E 446 1 O LEU E 444 N ASN E 310
SHEET 1 AB9 5 HIS F 336 ASN F 340 0
SHEET 2 AB9 5 LEU F 388 HIS F 393 1 O LEU F 391 N VAL F 337
SHEET 3 AB9 5 ILE F 418 ILE F 424 1 O TYR F 419 N LEU F 390
SHEET 4 AB9 5 ASN F 310 TYR F 314 1 N LEU F 313 O ALA F 422
SHEET 5 AB9 5 TRP F 443 TYR F 446 1 O LEU F 444 N ASN F 310
SHEET 1 AC1 5 HIS G 336 ASN G 340 0
SHEET 2 AC1 5 LEU G 388 HIS G 393 1 O LEU G 391 N VAL G 337
SHEET 3 AC1 5 ILE G 418 ILE G 424 1 O TYR G 419 N LEU G 390
SHEET 4 AC1 5 ASN G 310 TYR G 314 1 N LEU G 313 O ALA G 422
SHEET 5 AC1 5 TRP G 443 TYR G 446 1 O LEU G 444 N ASN G 310
SHEET 1 AC2 5 HIS H 336 ASN H 340 0
SHEET 2 AC2 5 LEU H 388 HIS H 393 1 O LEU H 391 N VAL H 337
SHEET 3 AC2 5 ILE H 418 ILE H 424 1 O TYR H 419 N LEU H 390
SHEET 4 AC2 5 ASN H 310 TYR H 314 1 N LEU H 313 O ALA H 422
SHEET 5 AC2 5 TRP H 443 TYR H 446 1 O LEU H 444 N ASN H 310
LINK CE2 PHE C 244 CG LEU C 246 1555 1555 1.46
LINK CE2 PHE C 244 CD1 LEU C 246 1555 1555 1.14
CISPEP 1 GLN A 209 TRP A 210 0 -1.49
CISPEP 2 SER A 489 THR A 490 0 -3.19
CISPEP 3 GLN B 209 TRP B 210 0 -0.16
CISPEP 4 SER B 489 THR B 490 0 -1.75
CISPEP 5 GLN C 209 TRP C 210 0 0.52
CISPEP 6 SER C 489 THR C 490 0 0.04
CISPEP 7 GLN D 209 TRP D 210 0 -0.87
CISPEP 8 SER D 489 THR D 490 0 0.04
CISPEP 9 SER E 397 GLN E 398 0 -2.20
CISPEP 10 GLN E 398 MET E 399 0 22.67
CISPEP 11 PRO E 453 TYR E 454 0 24.49
CISPEP 12 SER F 397 GLN F 398 0 -1.79
CISPEP 13 GLN F 398 MET F 399 0 22.21
CISPEP 14 PRO F 453 TYR F 454 0 24.38
CISPEP 15 SER G 397 GLN G 398 0 -2.45
CISPEP 16 GLN G 398 MET G 399 0 23.07
CISPEP 17 PRO G 453 TYR G 454 0 24.30
CISPEP 18 SER H 397 GLN H 398 0 -2.03
CISPEP 19 GLN H 398 MET H 399 0 22.20
CISPEP 20 PRO H 453 TYR H 454 0 24.00
CRYST1 87.260 114.961 316.455 90.00 90.72 90.00 P 1 21 1 8
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 0.011460 0.000000 0.000143 0.00000
SCALE2 0.000000 0.008699 0.000000 0.00000
SCALE3 0.000000 0.000000 0.003160 0.00000
(ATOM LINES ARE NOT SHOWN.)
END
