#=GF ID   DUF2101
#=GF AC   PF09874.13
#=GF DE   Predicted membrane protein (DUF2101)
#=GF AU   COGs;
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   COGs (COG4025)
#=GF GA   22.00 22.00;
#=GF TC   22.10 22.50;
#=GF NC   21.60 21.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR018663;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This domain, found in various archaeal and bacterial proteins,
#=GF CC   has no known function.
#=GF SQ   24
#=GS Q8U1B8_PYRFU/25-230      AC Q8U1B8.1
#=GS U6EDD8_9EURY/69-284      AC U6EDD8.1
#=GS O26523_METTH/81-293      AC O26523.1
#=GS A0A328PHV1_9EURY/56-260  AC A0A328PHV1.1
#=GS A0A133UAR6_9EURY/36-245  AC A0A133UAR6.1
#=GS F0T695_METLA/90-297      AC F0T695.1
#=GS W9S555_9ROSA/123-297     AC W9S555.1
#=GS A0A133UKT6_9EURY/21-95   AC A0A133UKT6.1
#=GS F0LLH4_THEBM/21-228      AC F0LLH4.1
#=GS A0A1D3L2A3_9EURY/90-296  AC A0A1D3L2A3.1
#=GS Q8TYT0_METKA/84-286      AC Q8TYT0.1
#=GS A0A133VCN3_9EURY/44-257  AC A0A133VCN3.1
#=GS Q5JIV8_THEKO/27-230      AC Q5JIV8.1
#=GS A0A4Q0XM88_9FLAO/3-67    AC A0A4Q0XM88.1
#=GS A0A133VLH4_9EURY/36-242  AC A0A133VLH4.1
#=GS A0A133V0X6_9EURY/40-253  AC A0A133V0X6.1
#=GS A0A133UEA8_9EURY/34-246  AC A0A133UEA8.1
#=GS A0A5N4D836_CAMDR/5-110   AC A0A5N4D836.1
#=GS C6A0G9_THESM/25-232      AC C6A0G9.1
#=GS A0A8J7T4I8_9ARCH/4-182   AC A0A8J7T4I8.1
#=GS Q81GR5_BACCR/3-91        AC Q81GR5.1
#=GS A0A133V4V7_9EURY/15-206  AC A0A133V4V7.1
#=GS E3GYT2_METFV/46-259      AC E3GYT2.1
#=GS A0A1D2W5C8_9EURY/74-290  AC A0A1D2W5C8.1
Q8U1B8_PYRFU/25-230                 ...........................TKNLLLPSPSQELPRS..ILGRL.AKRAKTPHELLSLKLQLVFLVYLIFSL.L.L...VF...MN.FWKIFIVVAFFYFLY....LRYLLIT....NRE....FFI...DY.QPYRA.F....Y.LSLSI..IAT.ISYGGFIIVR....EYSTS.P...Y....HYYI..YLLAVL.ATV..LVFRHWFKSKYGRDYT.YGVV.EEVKGD.LVRVYVHDDIAANV.KPGYYWLPAVP..DAEPGRIVKILVEEQT..L..R.GAKPVRII..............
U6EDD8_9EURY/69-284                 .......................pkes----EIPETNSEANESsdILLIS.TPFTSKEKEDTIFRLQLLSSGFIILSV.I.Y...LF..nFL.SFIIYGILGVLLVGY....IIYLLFN....RVK....VMYg.sEF.PAYRD.Ff.lmY.IAVGI..ILV.IVGNNPALVT....TFSLS.Y...F....PSLT..IFIFAI.IAV..AIVYLLFRIRYHRDFT.YGVV.IETGEK.MAYVKVEYDIRSNV.KPDIYVVENDY..GALDGDTVKLETEKKI..LsnS.GNKPIRII..............
O26523_METTH/81-293                 ..........................a-RNHDIRIPEDDAP--..IIIRT.PQFDPAEKENAVLKLQIAASLFIIISI.V.Y...VF..nFI.SILVFLPAALLLLAL....LLYILYR....QIR....VMYp.gDF.EAYRD.Ff.lmY.VAVGV..VII.LVSGNSALTM....AFPFV.F...F....PALT..TLLFAV.IAV..AAVFLIFRVRYVRDYT.FGEV.IEVGEN.TSYVRVDYDIRSNV.KPDVYIVENNG.fHVDVHDTVKLAVEGSVmsM..R.GNRPVRII..............
A0A328PHV1_9EURY/56-260             ............vtsekgeenisgdvf----------------..-----.--FDPGEKENAVLKLQVSAAAFIITSI.L.Y...AF..nIL.SLFIFLPVSIILILL....VAYILYY....QIK....IMYp.dDF.QAYRD.Ff.lmY.IAVGF..LII.IVANNPLIYS....LFSFT.L...L....PSLG..VLIFAL.VAV..AAIFIIFRVRYYRDYT.FGEV.IEVGEN.TSQVRVDYDIRANV.KPDIYIVENND.fKVKEHDIVKLSIESSL..F..R.ESKPKKII..............
A0A133UAR6_9EURY/36-245             .......................tlqr-----ARSPERKVP-S..YLRNFfRQRHAGWPEYVILKIQITIVLLFGFTA.V.T...VL...IK.DFW-LIFGSILFLLS....LYAALLT....KFQlkagFKL...DY.PAYRS.F....-.--VGI..CVG.LAWGAVLLLNypmpAFGEE.L...L....KTVL..PIAIVL.VGA..VLSFAGFRAKYGRDHT.YGIV.QEVKNG.KTKVRTRYDLRSNT.KQGVYFVDSFV..PVEKNDVVKVRVDRSTlgL..R.GST-----vrai..........
F0T695_METLA/90-297                 ..........hyessdddsgfimigga----------------..-----.--FSAEEKERTVLILQILSALFIVLSI.L.S...IF..nFI.SAIIYIPLGIVVVGY....IVYLIYN....KIK....LMYk.sDF.NAYRD.Ff.lmY.IAVGV..ILY.VINFNTNLVM....SFSFE.V...L....PSLT..VLIFAL.VAV..IAVFLIFRVRYYRNFT.YGTV.LDSGKN.TAHVKVDYDIRSNV.KPDIYIVENHI..GAVEGEQVKLQLEEKLmsM..S.GNRPVNII..............
W9S555_9ROSA/123-297                .....................etipsl----------------..-----.-------------------QLYFLLGL.V.Y...MV...VT.PILLPFMVVFFA---....LAYLVYR....HQI....INVynqQY.ESAAA.F....W.PHVHTriIAS.LFISQLLLMG....LLSTK.K...A....ANST..PLLVVLpILT..IAFHKYCKHRFEPAFRkYPLE.EAMAKD.TAERAAEPDLNLKAyLADAYLHPIFQ..SFEEEETVKVRVDKHQ..T..H.TASP----ts............
A0A133UKT6_9EURY/21-95              ......................yphya----------------..-----.---------------------------.-.-...--...--.---------------....-------....---....---...--.-----.-....-.-----..---.----------....-----.-...-....----..------.---..--------WEYGRDPT.YGVV.QEVKNG.KAKVKTRYDLRSNT.KQGVYFVDSFV..PVEKNDVVKVGVDRSTlgL..R.GS------tveai.........
F0LLH4_THEBM/21-228                 ...........................VKDFTNPKPQEKPPSF.kLLRKL.VKKKVTVHELLVLKLQLTFLFYMFLALlL.V...VF...LP.NELYLVILTAVYFIY....LRVIFRK....YRE....FFI...EH.EPYQV.F....Y.YSISI..IGF.LAFFGYVLLK....RFSLD.I...R....YSLG..YLVFVF.VAV..LMFRFYFKSKYGRDWT.YGVI.EDIKEN.VVKISVHDDIRANV.KPGEYWVDKVP..DVEIGRIVKVLVEERA..F..R.GAVPTKII..............
A0A1D3L2A3_9EURY/90-296             ...........skqmdgsedtifisgs----------------..-----.--FNYKEKENTILRLQILSGAFIIFSI.L.Y...IF..nFI.AGIIYGILGILTVGY....VVYLLYK....RIK....LMYs.nDF.PAYRD.Ff.lmY.IVIGL..VLV.VVGTNSTFVN....AFSFQ.F...F....PSLT..VLIFAL.ILV..AAVFLIFRIRYYRNYT.YGEV.VEAGKN.VAYVKIEYDIRSNV.KPDIYMVENSI..GAVEGDFVKVKLEEKFmnL..T.GNKPTNII..............
Q8TYT0_METKA/84-286                 irgkriaaaprmpwdvpvlvlqfslla----------------..-----.------------------TVVFVILEE.I.VappVM...LW.EALAVISAFVTAFSLg..wLRRVS--....PSE....-DI...HW.LPYWH.StliiL.GSVVL..SAI.LTNVPPVVAL....VLPLEgV...L....PGFI..VFGLPA.LGV..AAATVWVRRKFHRTWT.FGVVlREVQEGgSVEVVVGHDIAANT.LPGEYIVEGSG..S--EGTPVLVEVEHSGfsL..T.GARPVRIL..............
A0A133VCN3_9EURY/44-257             .................irvkkkskak----------PTVPKI..LQGFF.EQRHAGWPEYVILKVQICVIILFAISA.I.F...AIfpgWT.PEVVFIPLILILVGY....TLYLVPT....QLK....RAFk.qDY.PAYRA.F....-.--IGI..ILI.IVFVLVVVLR....YISFG.I...VespqMALV..PVILVI.GSI..LGAFAAFRVKYGRNYT.YGVV.QRVRDS.KAAVRITYDIRSNV.KHGLHFLETLV..KVKSGDRVKVGVERSMwgL..R.GSEPTTIL..............
Q5JIV8_THEKO/27-230                 ...........................MKMMLKPIPSARPPKS..--WPI.QKQWMTPHEVTSLLLQLIFLGYLVTGV.V.V...AY...LG.YFLALIILSAFYFLV....LRFILVR....YSD....YIL...DF.EAYRV.F....Y.LVVST..IAF.VSYVGYVLLR....RLSLD.A...Y....WYYA..YLGVIG.LVV..ILFRHYFKSRYGRDYT.YGVV.EEVKND.LVKVFVHDDMAANV.KPGYYWVPAVP..DAEPGVVVKLLVEERV..F..R.SSRPIRIL..............
A0A4Q0XM88_9FLAO/3-67               ........................ipv----------------..-----.---------------------------.-.-...--...--.---------------....-------....---....---...--.----M.F....Y.VVITT..LLL.-VTLTIMVAM....DMPLN.W...V....FYLT..CLGQIL.VVV..MAYK-VLRDKYVTDKT.FE--.------.--------------.-----------..----------------..-..-.--------dfyed.........
A0A133VLH4_9EURY/36-242             .........................lr--EKRTKEPERNIPNR..LQGFF.KNREAGWPEYVMLKAQISIILLFIFTV.V.S...VL...TEgPWLIFGPILLILSVY....TAVLSHN....QLK....IAFg.kDY.PAYRA.F....-.--VGI..CIG.IAWGANFLLR....YFPPV.S...E....GILIesTLPIML.VITgaIFAFIIFRIKYGRSHT.YGIV.LESKED.KAKVKVRYDLRSNA.KQGVYYVESFV..PVEKDDMVKINVDRSMlgL..-.--------rgfa..........
A0A133V0X6_9EURY/40-253             .................irvkkkskak----------PTVPKI..LQGFF.EQRHAGWPEYVILKVQICVIILFAISA.I.F...AIfpgWT.PEVVFIPLILILVGY....TLYLVPT....QLK....RAFk.qDY.PAYRA.F....-.--IGI..ILI.IVFVLVVVLR....YISFG.I...VespqMALV..PVILVI.GSI..LGAFAAFRVKYGRNYT.YGVV.QRVRDS.KAAVRITYDIRSNV.KHGLHFLETLV..KVKSGDRVKVGVERSMwgL..R.GSEPTTIL..............
A0A133UEA8_9EURY/34-246             ..............ntditkkfsptnp-----------EVPKL..LRNFF.SKRHAGWPEYVILKVQVTIVLLFGITA.V.T...VL...IE.DFW-LIFGSILFLLS....LYAALLTkfqlKAA....FEL...DY.PAYRS.F....-.--VAI..CVG.LAWGAVVILNypmpAIGEK.L...L....ETVL..PIAIVL.VGA..ILSFVGFRAKYGRDHT.YGVV.QEVKNG.KAKVKTRYDLRSNT.KQGVYFVDSFV..PVERNDVVKVGVDRSTlgL..R.GS------tveai.........
A0A5N4D836_CAMDR/5-110              ...............asnkwldpefhh----------------..-----.--NLYSKHQVVNLLMAILLTVELIYIL.V.F...VF...LD.NACVLFAVSVLMFIIssvlVHGTISY....QVG....WLI...PF.FCYRL.F....D.FVLSC..LIG.ISSLTYL---....-----.-...-....----..------.---..----------------.----.------.--------------.-----------..----------------..-..-.--------prikeyl.......
C6A0G9_THESM/25-232                 ...........................IKDIVNPTPFQKPPRF.kILKKL.IKRELTVHELLSLNLQLSFIFYLLLAL.LlI...VL...FG.NELYLTIISVVYFIY....LRYTLLK....NRD....FFI...EV.EPYRF.F....Y.YGLTA..IGF.LSFLGYLLIR....RFAKN.V...Y....YFYT..YLIAIF.VVV..LAFRYIYKSKFTRDWT.YGIV.EDIKGE.LVLVSVHDDIRANV.KPGKYWVDNTE..DVEVGDVVKILIEERI..F..R.SSLPKRVL..............
A0A8J7T4I8_9ARCH/4-182              .....................lskfef----------------..-----.-----------------LVLVFLLLVL.F.S...A-...LV.NPLFLFLAFLVFFLQ....YKYVEGE...vRRE....YPE...DW.KKYLLtFt..fYeLMVSI..MVFgISYSLFAGKS....GSLLD.LgriY....SAFF..VIFAVF.III..AASMMFL----RRRYT.FGTV.LFYKDE.WVGVAVKGDLFSKI.REGNYAVENPKktKVTKGDRVRVRVEKKR..F..S.GTFP----sll...........
Q81GR5_BACCR/3-91                   .....................etissn----------------..-----.---------------------------.-.-...--...--.--------KFFYLIL....LSLVLIT....TVN....VIL...RWeEAYFF.M....Y.LALHL..LGI.LCISGGVVTE....KKNEE.S...V....NYMC..VIGLVL.LLA..V---------------.----.------.--------------.-----------..----------------..-..-.--------qgimkyssfslqdf
A0A133V4V7_9EURY/15-206             ..............ntditkkfsptnp-----------EVPKL..LRNFF.HQRHAGWPEYVILKVQVTIVLLFGITA.V.T...VL...IG.DFW-LIFGSILLLLS....LYAALLTkfqlKAA....FEL...DY.PAYRS.F....-.--VAI..CVG.LAWGAVVILNypmpAIGEK.L...L....ETVL..PIAIVL.VGA..ILSFVGFRAKYGRDHT.YGVV.QEVKNG.KAKVKTRYDLRSNT.KQGVYFVDSFV..PV--------------..-..-.--------ektt..........
E3GYT2_METFV/46-259                 ..............qnkwemnknkdeg--------------EI..IVKDI.KIMDIKEKEKTVFKLQILSITFVLLSI.L.Y...IF..nYL.SLPLYLFLGIATICL....IYYILKY....QIR....VMYp.qDY.EVYRN.Ff.lsY.VGIGI..FLV.MIADNPLFVL....YAPFQ.Y...F....PSIT..LILFSI.FLV..LLMYYVFRIKYYRNYT.YGEV.VEVGKN.TVHVKVDYDIRANV.LPDIYIVEKGN.fDVKEGEIVKLKVEGGRlsV..K.GNKPTKII..............
A0A1D2W5C8_9EURY/74-290             ...aaeifivnnkenidkskvqsfein----------------..-----.KDFTSKQKERTVFVLQLLSLGFLALSI.L.Y...LF..nFL.SFVIYCILGVLLVGC....MVYILFS....KVK....LMYh.aDF.NAYRD.Ff.lmY.VAAGI..ILV.LFGTNSNLVM....AFSFD.F...F....PSFT..VLLFAV.IFS..IAVFLIFRIRYHRNYT.YGTV.IEAGKK.TAYVTVDYDICSNV.KPDTYIVDNSY..GANEGEIVKLQVEEKL..L.sRsGNKPICIL..............
#=GC seq_cons                       .....................................................hp.t..E.s.LhlQlhhhhhhhhsl.l.h...lh...hh.shhhhh.lsllhhhh....lhhllhp....phc....hhh...Da..uYRs.F....a.hslul..llh.lshssslllp....thuhp.h...h.....shs..slhhsl.lsl..lhhhhhFRh+YtRsaT.YGhV..-stps.hstVplcaDlRuNs.K.shYhV-s....sspps-hVKltVEcph..h..p.Gs.P..................
//