GenomeNet

Database: Pfam
Entry: GST_C_5
LinkDB: GST_C_5
Original site: GST_C_5 
#=GF ID   GST_C_5
#=GF AC   PF16865.4
#=GF DE   Glutathione S-transferase, C-terminal domain
#=GF AU   Eberhardt RY
#=GF SE   PDB:4ags
#=GF GA   27.00 27.00;
#=GF TC   27.00 27.00;
#=GF NC   26.90 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   22753509
#=GF RT   Leishmania TDR1 structure, a unique trimeric glutathione
#=GF RT   transferase capable of deglutathionylation and antimonial
#=GF RT   prodrug activation.
#=GF RA   Fyfe PK, Westrop GD, Silva AM, Coombs GH, Hunter WN;
#=GF RL   Proc Natl Acad Sci U S A. 2012;109:11693-11698.
#=GF CC   Leishmania major and Trypanosoma cruzi glutathione-S-transferase
#=GF CC   (GST) has undergone gene duplication, diversification, and gene
#=GF CC   fusion leading to an four domain enzyme which contains two
#=GF CC   repeats of a GST N-terminal domain followed by a GST C-terminal
#=GF CC   domain [1].
#=GF SQ   128
#=GS A4HJ18_LEIBR/321-429      AC A4HJ18.1
#=GS S9UF68_9TRYP/100-207      AC S9UF68.1
#=GS A0A024T8D7_9STRA/126-220  AC A0A024T8D7.1
#=GS Q4DKI7_TRYCC/93-200       AC Q4DKI7.1
#=GS A0A024T8P1_9STRA/120-229  AC A0A024T8P1.1
#=GS T0RC32_9STRA/3-93         AC T0RC32.1
#=GS A0A0T7BRB9_9CYAN/96-201   AC A0A0T7BRB9.1
#=GS S9VT66_9TRYP/325-434      AC S9VT66.1
#=GS A0A0B0MNJ3_GOSAR/116-218  AC A0A0B0MNJ3.1
#=GS A4I8P2_LEIIN/97-204       AC A4I8P2.1
#=GS A4I8P2_LEIIN/97-204       DR PDB; 4AGS B; 321-429;
#=GS A4I8P2_LEIIN/97-204       DR PDB; 4AGS A; 321-429;
#=GS A4I8P2_LEIIN/97-204       DR PDB; 4AGS C; 321-429;
#=GS S9VT66_9TRYP/100-207      AC S9VT66.1
#=GS A0A163ATB0_PHYB8/97-207   AC A0A163ATB0.1
#=GS K9RTH3_SYNP3/140-237      AC K9RTH3.1
#=GS A0A061J8G9_TRYRA/317-426  AC A0A061J8G9.1
#=GS S2K176_MUCC1/95-209       AC S2K176.1
#=GS S9TTN0_9TRYP/106-214      AC S9TTN0.1
#=GS I1CM52_RHIO9/64-178       AC I1CM52.1
#=GS W6KHE2_9TRYP/322-430      AC W6KHE2.1
#=GS A0A0F5ZU63_9GAMM/86-195   AC A0A0F5ZU63.1
#=GS A0A061J8G9_TRYRA/93-200   AC A0A061J8G9.1
#=GS K9VR25_9CYAN/141-238      AC K9VR25.1
#=GS S9UET7_9TRYP/9-116        AC S9UET7.1
#=GS T0R0N6_9STRA/121-229      AC T0R0N6.1
#=GS A0A067C4X0_SAPPC/118-227  AC A0A067C4X0.1
#=GS Q4DKI7_TRYCC/317-426      AC Q4DKI7.1
#=GS A0A067BUB5_SAPPC/117-226  AC A0A067BUB5.1
#=GS W4FUG8_9STRA/189-280      AC W4FUG8.1
#=GS K2N3V3_TRYCR/93-200       AC K2N3V3.1
#=GS A0A0D1Z240_9PEZI/462-558  AC A0A0D1Z240.1
#=GS W6KHE2_9TRYP/94-202       AC W6KHE2.1
#=GS A0A0S4IX62_BODSA/352-460  AC A0A0S4IX62.1
#=GS A0A0A1PFX7_9FUNG/94-207   AC A0A0A1PFX7.1
#=GS W4FT04_9STRA/141-230      AC W4FT04.1
#=GS A0A162TI71_MUCCL/95-208   AC A0A162TI71.1
#=GS A9UQ13_MONBE/117-231      AC A9UQ13.1
#=GS W7U0V7_9STRA/178-248      AC W7U0V7.1
#=GS D8RDP0_SELML/94-183       AC D8RDP0.1
#=GS V5DBY4_TRYCR/93-200       AC V5DBY4.1
#=GS A5GU39_SYNR3/148-246      AC A5GU39.1
#=GS L8WN63_THACA/25-109       AC L8WN63.1
#=GS L8LU00_9CHRO/146-237      AC L8LU00.1
#=GS S9TQ57_9TRYP/317-375      AC S9TQ57.1
#=GS A0A0B7MTA8_9FUNG/94-207   AC A0A0B7MTA8.1
#=GS A0A067BUS6_SAPPC/120-229  AC A0A067BUS6.1
#=GS A0A168LAE8_MUCCL/101-212  AC A0A168LAE8.1
#=GS M1WYB5_9NOST/134-240      AC M1WYB5.1
#=GS A0A0C9MS70_9FUNG/101-212  AC A0A0C9MS70.1
#=GS A0A0S4KHM5_BODSA/356-463  AC A0A0S4KHM5.1
#=GS A0A0C9MK04_9FUNG/94-208   AC A0A0C9MK04.1
#=GS W9QL25_9ROSA/461-563      AC W9QL25.1
#=GS T0PJI9_9STRA/35-144       AC T0PJI9.1
#=GS A0A067CW93_SAPPC/107-196  AC A0A067CW93.1
#=GS S9UW10_9TRYP/317-426      AC S9UW10.1
#=GS A0A022RII8_ERYGU/177-280  AC A0A022RII8.1
#=GS Q4CZ29_TRYCC/317-426      AC Q4CZ29.1
#=GS S9UF68_9TRYP/325-434      AC S9UF68.1
#=GS A0A176WRF6_MARPO/161-260  AC A0A176WRF6.1
#=GS W6L2H9_9TRYP/94-202       AC W6L2H9.1
#=GS A0A0D8ZQS0_9CYAN/140-240  AC A0A0D8ZQS0.1
#=GS D8TYM3_VOLCA/394-496      AC D8TYM3.1
#=GS T0PWZ5_9STRA/121-229      AC T0PWZ5.1
#=GS K1PPL5_CRAGI/100-202      AC K1PPL5.1
#=GS W4GKN3_9STRA/135-228      AC W4GKN3.1
#=GS A0A059LI74_9CHLO/94-208   AC A0A059LI74.1
#=GS A4I8P2_LEIIN/321-429      AC A4I8P2.1
#=GS A4I8P2_LEIIN/321-429      DR PDB; 4AGS B; 321-429;
#=GS A4I8P2_LEIIN/321-429      DR PDB; 4AGS A; 321-429;
#=GS A4I8P2_LEIIN/321-429      DR PDB; 4AGS C; 321-429;
#=GS D8R5E7_SELML/155-239      AC D8R5E7.1
#=GS K9Y7Y6_HALP7/140-238      AC K9Y7Y6.1
#=GS A0A0F4QUR7_9GAMM/94-201   AC A0A0F4QUR7.1
#=GS A0A168LFR9_MUCCL/102-213  AC A0A168LFR9.1
#=GS K2N3V3_TRYCR/317-426      AC K2N3V3.1
#=GS A0A067BUB1_SAPPC/122-227  AC A0A067BUB1.1
#=GS T0QTT0_9STRA/114-221      AC T0QTT0.1
#=GS A0A067C4X2_SAPPC/121-229  AC A0A067C4X2.1
#=GS A0A0P4UMM9_9CYAN/154-244  AC A0A0P4UMM9.1
#=GS A0A0N0DT12_9TRYP/96-203   AC A0A0N0DT12.1
#=GS W4HCG7_9STRA/112-222      AC W4HCG7.1
#=GS K9PXD3_9CYAN/143-240      AC K9PXD3.1
#=GS D8G100_9CYAN/147-245      AC D8G100.1
#=GS S9UET7_9TRYP/234-343      AC S9UET7.1
#=GS A0A0A1PJZ6_9FUNG/96-207   AC A0A0A1PJZ6.1
#=GS A0A024USH6_9STRA/119-222  AC A0A024USH6.1
#=GS F0XX91_AURAN/167-272      AC F0XX91.1
#=GS W4GLJ9_9STRA/135-228      AC W4GLJ9.1
#=GS A0A0S4KHM5_BODSA/132-237  AC A0A0S4KHM5.1
#=GS A8GZU3_SHEPA/98-199       AC A8GZU3.1
#=GS W6L2H9_9TRYP/322-430      AC W6L2H9.1
#=GS M1X389_9NOST/57-163       AC M1X389.1
#=GS L8N7T1_9CYAN/142-240      AC L8N7T1.1
#=GS T0R0P0_9STRA/56-158       AC T0R0P0.1
#=GS F2UCJ5_SALR5/117-228      AC F2UCJ5.1
#=GS A0A0S4IX62_BODSA/127-235  AC A0A0S4IX62.1
#=GS A0A022RNK7_ERYGU/117-218  AC A0A022RNK7.1
#=GS S9TQ57_9TRYP/93-200       AC S9TQ57.1
#=GS T0QVR1_9STRA/115-227      AC T0QVR1.1
#=GS A0A024UTA8_9STRA/111-222  AC A0A024UTA8.1
#=GS L8H4T1_ACACA/99-212       AC L8H4T1.1
#=GS A0A165II81_EXIGL/93-208   AC A0A165II81.1
#=GS A0A0L0TA68_ALLMA/67-180   AC A0A0L0TA68.1
#=GS A4HJ18_LEIBR/97-204       AC A4HJ18.1
#=GS A0A0L0T6D3_ALLMA/131-231  AC A0A0L0T6D3.1
#=GS B7KL51_CYAP7/139-239      AC B7KL51.1
#=GS A0A0D2QIW4_GOSRA/117-218  AC A0A0D2QIW4.1
#=GS S9UW10_9TRYP/93-200       AC S9UW10.1
#=GS A0A0N0DT12_9TRYP/320-429  AC A0A0N0DT12.1
#=GS W4HAC4_9STRA/118-222      AC W4HAC4.1
#=GS U5DLV0_9CHRO/140-240      AC U5DLV0.1
#=GS G2IN94_9SPHN/95-205       AC G2IN94.1
#=GS G2IN94_9SPHN/95-205       DR PDB; 4YAV A; 95-205;
#=GS G2IN94_9SPHN/95-205       DR PDB; 4YAP A; 95-205;
#=GS S9TTN0_9TRYP/335-449      AC S9TTN0.1
#=GS A0A165ANS3_9APHY/66-148   AC A0A165ANS3.1
#=GS K9Z199_CYAAP/155-239      AC K9Z199.1
#=GS Q4CZ29_TRYCC/93-200       AC Q4CZ29.1
#=GS G4QF58_GLANF/109-200      AC G4QF58.1
#=GS A0A067BTL6_SAPPC/118-229  AC A0A067BTL6.1
#=GS A0A067BVQ3_SAPPC/117-226  AC A0A067BVQ3.1
#=GS K5UTW3_PHACS/122-223      AC K5UTW3.1
#=GS Q70GE8_LEIMA/97-204       AC Q70GE8.1
#=GS A0A068SC34_9FUNG/91-205   AC A0A068SC34.1
#=GS S2JI82_MUCC1/101-212      AC S2JI82.1
#=GS T0PTI3_9STRA/60-156       AC T0PTI3.1
#=GS T0PY11_9STRA/174-263      AC T0PY11.1
#=GS E1ZHD6_CHLVA/99-217       AC E1ZHD6.1
#=GS Q70GE8_LEIMA/321-429      AC Q70GE8.1
#=GS L8GFR3_ACACA/88-196       AC L8GFR3.1
#=GS V5DBY4_TRYCR/317-426      AC V5DBY4.1
#=GS A0A0C9Z9N8_9HOMO/121-203  AC A0A0C9Z9N8.1
#=GS K9RDG2_9CYAN/142-240      AC K9RDG2.1
#=GS E0ULF3_CYAP2/145-239      AC E0ULF3.1
#=GS T0R7R9_9STRA/121-229      AC T0R7R9.1
A4HJ18_LEIBR/321-429                 ...............................................YEVGFFLDN.A.G.Y.FVT.GLL.S.WFF..G...G...-.SE..D.....A.....KA...E.....F..EW......A....A.V....EL...E...Q..Q.....L....AK....HP...fGE..GP..FFGGKTMNAGDVAI.LPFLVRVKSLTPEL..tNGY.D..F...F.....A...K......FPLL....NELAEAGM.VTPEAKA-v...............................
S9UF68_9TRYP/100-207                 ...............................................HKVEFFLSQ.V.G.D.LVS.AAY.N.LLR..D...P...Y.NG..E.....R.....RQ...F.....L..DD......N....I.A....YI...E...N..I.....I....AE....TQ....LA..GP..FYLDERFSMADVVL.LPFLARFKSVLPYY...TGF.D..L...F.....S...K......APRM....AKVYAAGM.KRPSVT--rd..............................
A0A024T8D7_9STRA/126-220             ..................................avakfeakpfyae---------.-.-.-.---.---.-.---..-...-...-.--..-.....-.....-A...E.....V..RE......I....L.A....EL...E...T..I.....Y....TN....HAkayrDQ..GP..YLLGANLSSAEINL.VPFFFRFDVLLTHY...HKV.D..V...F.....T...D......IPHL....KAALAAAV.GRPAFQQ-t...............................
Q4DKI7_TRYCC/93-200                  ...............................................HRVEFFLSE.I.G.D.LVK.AYF.G.LVR..D...P...F.NE..E.....K.....RK...S.....V..DH......N....T.A....YI...E...G..I.....I....AE....HQ....GD..GP..YFLDDTFSMAEVMV.VPFLACFRPVLSYY...CGY.D..I...F.....H...E......APRL....KKMYVTSM.QRTTVKET................................
A0A024T8P1_9STRA/120-229             ..............................stvaqlviakfdalpwy---------.-.-.-.---.---.Q.YLR..T...G...-.DE..K.....A.....KV...E.....G..KE......N....L.Q....VV...E...T..I.....F....TV....NAkaysEH..GP..YLLGADLSSAEINL.FPFFYRLEILLGHY...RQL.D..F...L.....A...D......YPTL....KAAFDAAK.SRKAFQ--qt..............................
T0RC32_9STRA/3-93                    ..........................................ktpnm---------.-.-.-.---.---.-.---..-...P...L.EA..E.....M.....RT...S.....L..QG......L....E.R....IY...R...E..H.....A....AA....FR....AK..GP..YLLGDRFSSAEINI.MTFLFRFDILLQHY...RQV.R..V...L....gD...D......IPLL....SAALEASM.ARPA----ftlt............................
A0A0T7BRB9_9CYAN/96-201              .........................................idfant---------.-.-.R.FVT.AFS.N.LLR..S...PdseT.QE..E.....A.....RR...D.....L..YK......H....L.E....FV...E...N..Q....aL....AK....LS....GN..GS..YWFGENISLVDLSF.YPWFERL-PALEYY...RGF.K..L...P.....S...E......FTRL....QQWQNAVS.QRESVQK-i...............................
S9VT66_9TRYP/325-434                 ...............................................YDIQYFVTC.A.G.N.FFG.AMY.G.FWQ..N...N...S.SK..E.....A.....KE...E.....L..QW......A....A.N....QL...V...K..L.....L....DV....KP...fGD..GP..FYGGKVPNAGDVSL.ISFLYRARVYHPER..tGGY.D..V...L.....A...D......YPRL....AALLDAAL.ATEAGK--av..............................
A0A0B0MNJ3_GOSAR/116-218             ..........................................rtlee---------.L.F.S.YAD.KFM.G.MLY..A...S...F.KG..D.....P.....EK...E.....A..GA......A....F.N....YL...E...D..A.....L....KK....Y-....DD..GP..FLLGRDFSLADIAY.IPFVERFQIFLSEV...FKY.D..I...I.....A...G......RPKL....AAWI----.--------eelnkidaykqt....................
A4I8P2_LEIIN/97-204                  ...............................................HQIEFFLAQ.V.G.D.FIG.AAH.G.LLR..D...P...L.SG..E.....K.....RK...A.....M..DD......N....A.A....YV...D...G..L.....L....AA....NQ....TT..GP..YYCDGEFTMADVAL.VPFLVRLKPALMYY...AGY.D..V...F.....C...K......APRM....KALWAAAA.QRASVRET................................
#=GR A4I8P2_LEIIN/97-204       SS    ...............................................HHHHHHHHH.H.H.H.HHH.HHH.H.HHH..S...T...T.-H..H.....H.....HH...H.....H..HH......H....H.H....HH...H...H..H.....H....HH....H-....SS..-S..EEEEEE--HHHHHH.HHHHHHHHHHHHHH...HS-.-..T...T.....T...T......-HHH....HHHHHHHT.TSHHHHTT................................
S9VT66_9TRYP/100-207                 ...............................................HKVEFFLSQ.V.G.D.LVG.AAY.N.LLR..D...P...Y.NG..E.....R.....RQ...F.....L..ED......N....I.A....YI...E...N..I.....I....AE....TQ....LA..GP..FYLDERFSMADVVL.LPFLARFKSVLPYY...TGF.D..L...F.....S...K......APRM....AKVYAAGM.KRPSVT--rd..............................
A0A163ATB0_PHYB8/97-207              .................faieyfatkisspwykvlfnygdetkegfi---------.-.-.-.---.---.-.---..-...-...-.--..-.....-.....-K...E.....T..EA......G....F.T....RL...G...E..L.....L....RE....QS....ET..GP..YFLGEEYSLADVAI.APFLGRVLLTFKHW..vGDY.KhkA...I.....Q...N......DKRL....EAFVEGIL.SRPSFKET................................
K9RTH3_SYNP3/140-237                 ...........................................rllf---------.-.-.-.--R.AWC.N.WLC..Y...P...-.TR..S.....A.....RE...E.....V..QN......K....A.Q....FL...QvvaQ..V.....E...aAL....AQ....TP..GP..FFLE-EFSTADVVF.VPYVERMNASLFYY...KGY.S..L...R.....E...E......NPSL....GE------.--------wftgletlptyr....................
A0A061J8G9_TRYRA/317-426             ..............................................y-FVKFAESN.V.G.H.FVG.AMF.S.LLR..N...P...K.NN..D.....A.....KE...E.....L..EW......A....A.G....EL...E...K..L.....L....AE....QR...fGA..GP..FFGGATINAADIAL.LPMLVRMKACTPAM..tEGY.D..L...F.....A...K......FKQL....AANLEAGM.KTMAGKET................................
S2K176_MUCC1/95-209                  ................................hvrfaieyfsskins---------.-.-.-.---.EFY.K.YVI..N...Q...S.AE..N.....A.....RE...N.....F..ET......Nv..nT.A....LIr.fN...E..L.....L....LQ....QS....KT..GP..YFLGDEYSLADVAI.APFVLRIHALLEQV..lDGY.K..Fe.aI.....K...S......NPRL....HEFISGAL.QRPSAKET................................
S9TTN0_9TRYP/106-214                 .............................................hk--VQ-FVSE.A.S.D.LIS.AGY.G.LLR..D...P...F.NK..E.....K.....RK...A.....V..ED......N....A.A....YL...N...R..I.....L....EE....GQt..eEE..GP..FVCGSYFTLADIAI.TPFLIRFDALLRYY...AGV.D..V...F.....Y...Q......APAL....RRLFLAAK.KRPSVV--at..............................
I1CM52_RHIO9/64-178                  ...............................yiryfieifsskvnse---------.-.-.-.---.-FF.K.FIF..N...I...K.EE..N.....A.....RI...E.....Y..EK......N....I.GasfeRL...N...E..L.....L....VQ....QS....PS..GP..YFLGNEYSLADIAV.APFVARIKGFNKLF..lDGY.E..Ie.aL.....K...K......FPRL....AEFFDAIT.DRPSFKET................................
W6KHE2_9TRYP/322-430                 ...............................................YAVSCFLRA.V.D.E.LIP.SIY.I.LSA..N...P...T.NL..E.....V.....RK...Q.....L..VS......A....L.E....KI...Q...N..Q.....F....DV....KM...fGA..GP..FLGGSTMNVCDVAL.LPFLVRLKAFTPEL..tNGY.D..A...F.....R...E......FPSL....DGYLKECM.ST------daknv...........................
A0A0F5ZU63_9GAMM/86-195              ......................................dkavqraws---------.-.-.-.YLG.TKH.Y.LMQ..C...G..tM.SS..K.....D.....KA...T.....F..DE......R....A.S....KL...Q...L..V.....Fq..kAE....KQl..tGD..TR..FFDSNTLGKVDVAW.LPLLHRA-AIIKKK...AGY.D..F...L.....C...G......LPKM....QAWQHAVL.ET------gyavksv.........................
A0A061J8G9_TRYRA/93-200              ...............................................HQVEFFLSQ.V.G.D.LIR.AYF.T.LLR..D...P...F.NA..E.....K.....RK...S.....V..DD......N....T.V....YI...E...G..I.....F....SA....NQ....GT..GP..YFLDEVISMADIML.IPFLVCFKPVLSYY...SGY.D..V...F.....Q...K......APRI....KEMYLAAV.QRPSVKET................................
K9VR25_9CYAN/141-238                 ...........................lfrawctwlcypassakaeq---------.-.-.-.---.---.-.---..-...-...-.--..H.....N.....RN...Q.....F..IS......V....V.A....QV...E...K..A.....L....AS....--....TP..GP..YFLD-EFGTADVIF.TPYVERMNASLYYY...KGY.S..M...R.....E...E......NPRF....ADWFAAME.TRPTYR--gt..............................
S9UET7_9TRYP/9-116                   ...............................................HKVEFFLSQ.V.G.D.LVS.AAY.N.LLR..D...P...Y.NG..E.....R.....RQ...F.....L..DD......N....I.A....YI...E...N..I.....I....AE....TQ....LA..GP..FYLDERFSMADVVL.LPFLARFKSVLPYY...TGF.D..L...F.....S...K......APRM....AKVYAAGM.KRPSVT--rd..............................
T0R0N6_9STRA/121-229                 .............................laqakfeagpfyallrnq---------.-.-.-.---.---.-.---..D...P...A.KK..D.....K....lEA...N.....L..RD......S....L.G....EL...E...K..I.....Y....RD....HAadfrAD..GP..YLLGADLSSAEINI.VPFLFRFKHVLGHY...RDF.D..V...T.....K...G......FPLL....TAAYEAAI.ARPAFK--lt..............................
A0A067C4X0_SAPPC/118-227             ...............lvvakfdivpsifaflrnkdaanddelqaiml---------.-.-.-.---.---.-.---..-...-...-.--..-.....-.....--...-.....-..-A......G....V.A....GL...E...R..I.....YredaAA....FR....SR..GP..YLLGDRLSQAEIAL.VPHLFRFSLLLRTY...RNT.E..L...L.....H...A......CPLL....AAALEAAT.KRPA----fqaa............................
Q4DKI7_TRYCC/317-426                 ...............................................YHVRFVESN.V.D.Y.FMD.AMY.S.LIK..D...P...K.NT..N.....A.....KE...E.....F..DW......A....A.G....EL...E...K..L.....L....AE....HQ...fGE..GP..FFGGATMNAADVSL.LPMLVHLKACTPDL..tEGQ.D..L...L.....A...N......YKLL....AAAAEAGL.TSEAGK--kv..............................
A0A067BUB5_SAPPC/117-226             ........................qlaqakfeigpfygllrnqdpak---------.-.-.-.---.---.-.--K..E...G...F.EA..D.....I.....RE...T.....L..DE......L....E.K....IY...R...E..H.....A....AE....FR....AK..GP..YLFGDQLSSAEINI.IPFFFRFQIILKHY...RDF.E..L...L.....K...G......YPLL....TAAYEAAV.ERPAFKQT................................
W4FUG8_9STRA/189-280                 .......................lshqnetdapvrallseletiyrd---------.-.-.-.---.---.-.---..-...-...-.--..-.....-.....--...-.....-..--......-....-.-....--...-...-..H.....A....KA....HR....AN..GP..FLLGANVSTGDINL.IPWLFRFEILLAHY...KAY.T..L...Lp...eK...D......FPLL....KAALEAAK.ALPTFQQ-t...............................
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W4GLJ9_9STRA/135-228                 ...................................arpfyvylqvgg---------.-.-.-.---.---.-.---..-...-...-.-A..R.....A.....EA...D.....V..RD......V....L.T....EL...E...T..I.....Y....NQ....HG....KE..GP..YLLGGTLSSAEINL.VPFFFRFNVLLKHY...RKV.D..L...F.....A...D......YPRL....KAALDAAV.VRPAFQQ-t...............................
A0A0S4KHM5_BODSA/132-237             ...............................................HRVRFFLEQ.V.G.E.FVG.SAY.G.FLS..D...R...-.--..A.....G.....KD...E.....F..EA......N....V.K....NL...E...K..L.....L....AE....QS....PS..GP..FFLGDTFSLADIAL.VPFLDRFRHTLFAF..vDGY.D..I...F.....A...S......APRL....KALHAAAT.LRPSVF--qt..............................
A8GZU3_SHEPA/98-199                  .............................asklylkqcshmqsptqq---------.-.-.-.---.---.-.---..-...-...V.FE..E.....R.....QE...Y.....L..QN......Q....F.A....KV...E...S..F.....L....KD....H-....TD..SQ..YFCANVIGNIDIAW.LPLFHRA-ALVQKH...TGM.R..L...F.....E...N......FPLL....QTWADNIM.ATGLA---ektvh...........................
W6L2H9_9TRYP/322-430                 ...............................................YAVSRFTEV.V.N.E.FTQ.IFY.A.LHS..D...P...G.NL..E.....L.....KE...Q.....L..VN......V....F.K....FL...H...T..Q.....F....DK....KM...fGC..GP..FFGGKTMNICDVAF.LPFLVRLKGATPDV..tNGY.D..A...F.....K...E......FPFL....EEYLKACL.NT-E----aknv............................
M1X389_9NOST/57-163                  ....................................fplrqlerllf---------.-.-.-.--K.AWC.A.WLC..Y...P...L.VS..Q.....KqekqnRE...Q.....F..IV......M....L.A....KC...E...E..A.....L....AN....--....TQ..GP..YFLE-TFGIIDIIF.IPYLERMNASLYYY...KGY.S..L...R.....E...E......NPNL....SKWFAAME.NRLT----yrgt............................
L8N7T1_9CYAN/142-240                 .........................ilfrawcewlcrpvmsaqqeqr---------.-.-.-.---.---.-.---..-...-...-.--..-.....H.....RH...Q.....F..GE......V....M.T....KV...E...E..A.....L....GN....--....TP..SP..YFLDD-FGTADVIF.TPYVERMNASLYYY...KGY.S..M...R.....E...E......NPRM....SDWFDAME.SRPTYR--gt..............................
T0R0P0_9STRA/56-158                  ..............................eagpffalllnqdpamk---------.-.-.-.---.---.-.---..-...-...-.-D..K.....L.....EA...N.....L..RD......S....L.G....EL...E...K..I.....Y....RD....HAadfrAD..GP..YLLGADLSSAEISI.VPFLFHFKHVLGHY...RDF.D..V...T.....K...G......FPLL....TAAYEAAI.ARPAFK--lt..............................
F2UCJ5_SALR5/117-228                 rfliamwgdkvfaklytvlrttdpcdrqcaweqllevlsffdhayee---------.-.-.-.---.---.-.---..-...-...-.--..-.....-.....--...-.....-..--......-....-.-....--...-...-..-.....-....--....SK...sKD..GP..YFMGNDLSMVEIVI.MPFIARFATLLPHY...HGL.N..F...F.....Kd.rH......IPTL....ERAYREVL.KRP-----afaat...........................
A0A0S4IX62_BODSA/127-235             ...............................................HRVRFFLEQ.I.G.E.FVG.AAY.G.LLF..D...L...K.SE..G.....K.....NA...E.....L..EA......N....L.K....NL...E...K..L.....L....AE....QS....PN..GP..FFLGETFSLADIAL.VPFLDRHRHLLFAF..aDGY.N..I...F.....A...N......APRL....KVLLDAAV.LRPSVF--qt..............................
A0A022RNK7_ERYGU/117-218             .........................................dfaeem---------.-.-.-.-IT.YLD.T.FLK..N...V...F.TS..L.....K.....RD...P.....I..EE......A....S.G....EF...D...Y..L.....E....TS....LKk..fDD..GP..FFIG-ELSQVDAAY.VPFIERFQIFLQEV...FEY.D..I...T.....A...G......RPKL....AAYL----.--------eeinkidaykqt....................
S9TQ57_9TRYP/93-200                  ...............................................HRIDFFLGE.V.G.D.LIG.AFY.G.VLR..D...P...F.NP..E.....K.....RK...N.....L..DD......N....I.Q....YL...E...G..I.....I....GD....TQ....KK..GP..FYLDDAFSMADVAL.LPFLIRMKPVLSYY...TGY.D..I...F.....A...K......APRM....RALWEAGK.ARPSV---aad.............................
T0QVR1_9STRA/115-227                 ............lanlvvaqfdivpsifaflrnkdttkddelkalvf---------.-.-.-.---.---.-.---..-...-...-.--..-.....-.....--...-.....-..-A......G....V.A....GL...E...R..I.....YqedaAA....FR....SR..GP..YLLGDRLSQAEIAL.VPYLFRFSLILRTY...RRV.E..L...L.....Y...A......CPLL....AAALDAAT.QRPAF---qaa.............................
A0A024UTA8_9STRA/111-222             ............................eeaalaqlaaakfeagply---------.-.-.-.---.---.Q.L-L..R...K...F.TD..E.....N.....VA...E.....L..KE......S....L.A....EV...E...A..V.....YringAE....YR....SQ..GP..YLLGNTLSNAEILT.ATVLFRFEIVLKHY...HNF.D..L...L.....T...D......FPLL....AAALAAVK.TRSA----fqqt............................
L8H4T1_ACACA/99-212                  ............................................yas---RFVIDQ.F.G.S.QVTpAVF.Q.LIK..N...Qd.rA.QD..D.....K....lKE...E.....L..TK......K....V.E....AF...A...E..L.....Y....AA....ESs..sKD..GP..YFLGESFSLVDLAI.VPFIYRFAIGLSHY...RGF.D..L...L.....A...V......DEKL....KRWHDAVT.QRPSWKT-t...............................
A0A165II81_EXIGL/93-208              ..............................................a-QIRYFVDTfV.S.K.VIA.PYH.S.FVS..Q...G...-.--..E.....K.....SD...E.....L..LK......G....I.E....TV...Q...D..L.....I....--....-P....AP..GP..FFLGDKYSAAEILI.APFLGRFKILVESD..iGGF.E..T...A.....E...G......KRVL....NTLT----.--------qdakfakfakyweavvsrpsvket........
A0A0L0TA68_ALLMA/67-180              ......................................amvtdamgs---------.-.-.H.FVP.AFY.G.LIR..E...K...-.DP..E.....K.....QA...E.....A..TA......K....L.I....EA...I...R..N.....V....AP....TL...hPD..GP..FALGDSFSWAEVMS.ASFLMRL-PVLKHY...RNF.D..M...P.....T...D......EPAF....ERF-----.--------qqwidavsahptvqattasvdd..........
A4HJ18_LEIBR/97-204                  ...............................................HRIEYFLTQ.V.G.D.FIG.AAH.E.LLG..D...P...L.SA..E.....K.....RS...A.....L..SD......S....A.A....YM...D...E..L.....L....AA....NQ....TT..GP..YYCDGEFTMADVAL.VPFLVRLKFVLMYY...AGY.D..V...F.....C...K......APRM....KALWAAAV.QRASVLET................................
A0A0L0T6D3_ALLMA/131-231             ........................................vteavnd---------.-.-.A.FVP.AFY.A.LLR..E...H...D.KE..T.....Q.....PA...A.....M..AK......L....L.S....AV...H...D..V.....G....AV....LD....AE..GP..YAVGTEWTLADTLA.APFLARLV-VVKHY...RGF.D..L...K.....D...A......APA-....--------.--------rdensarfvrwanal.................
B7KL51_CYAP7/139-239                 .........................................erllfr---------.-.-.-.---.AWC.S.WLC..Y...P...T.-R..S.....S.....KQ...E.....Q..QN......R....Q.Q....FI...Kv.vE..M.....Ve..dAL....SR....TD..GP..YFLD-PFGTVDVIF.TPYVERMNASLYYY...KGY.S..L...R.....E...E......NPHL....AKWFEAME.SRPTYR--gt..............................
A0A0D2QIW4_GOSRA/117-218             ........................................tleells---------.-.-.-.YAD.KFM.E.MLF..A...S...F.KG..D.....P.....EK...E.....A..GA......A....F.N....YL...E...D..A.....L....KK....Y-....DD..GP..FLLGRDFSLADIAY.IPFVERFQIFLSEV...FKY.D..T...I.....A...G......RPKL....AAWI----.--------eelnkidaykqt....................
S9UW10_9TRYP/93-200                  ...............................................HRIDFFLGE.V.G.D.LIG.AFY.G.VLR..D...P...F.NP..E.....K.....RK...N.....L..DD......N....I.Q....YL...E...G..I.....I....GD....TQ....KK..GP..FYLDDAFSMADVAL.LPFLIRMKPVLSYY...TGY.D..I...F.....A...K......APRM....RALWEAGK.ARPSV---aad.............................
A0A0N0DT12_9TRYP/320-429             ...............................................YEVTFFIDN.A.S.N.FVG.AMY.Y.FTS..H...P...E.DK..D.....T.....KA...E.....L..LW......A....A.G....EL...E...K..Q.....L....AK....HP...fGE..GP..FFGGTQMNLGDVSV.LPFLVRLKAYTPAL..tAGY.N..L...F.....S...E......FPLL....SGLLEAGM.ASAEGKEV................................
W4HAC4_9STRA/118-222                 ...............................laaakfevgplyralg---------.-.-.-.---.---.-.---..-...G...T.SE..D.....N.....VA...A.....L..KE......T....L.G....DV...E...T..I.....Y....RV....HAkefrSS..GP..YLLGSKLSGAEILI.VPFLFRFDILLQHY...RGY.T..L...L.....D...G......FPLL....QGVLAAAK.ARPAFQD-t...............................
U5DLV0_9CHRO/140-240                 ............................................ere---------.-.-.-.LFR.AWC.S.WLC..R...P...T.RSprA.....E.....RA...N.....R..DQ......F....T.V....VV...E...Q..V.....E....AA....LQ...qTP..GP..YFLE-EFGIVDVIF.APYVERMNASLYYY...KGY.S..L...R.....E...A......NPAL....GVWFDAME.SRPTYR--gt..............................
G2IN94_9SPHN/95-205                  .............................................ha--VEGMLAElA.G.P.FSG.AGY.R.MIL..NreiG...K.RE..E.....M.....RA...A.....V..DA......E....F.G....KV...D...A..F.....L....KR....YA....TG..SD..FLFDDRFGWAEVAF.TPMFKRL-WFLDYY...EDY.E..V...P.....A...N......FDRV....LRWRAACT.AHPAA---qyr.............................
#=GR G2IN94_9SPHN/95-205       SS    .............................................HH--HHHHHHHTH.H.H.HHH.HHH.H.HHH..---GG...G.HH..H.....H.....HH...H.....H..HH......H....H.H....HH...H...H..H.....H....HH....H-....-S..SS..SSSTT---HHHHHH.HHHHHHT-HHHHHH...S--.-..-...-.....T...T......-HHH....HHHHHHHH.HSGGG----SS.............................
S9TTN0_9TRYP/335-449                 ...............................................YAMEFFNTK.T.Q.E.FST.AMV.R.VLK..Q...S...NpSA..D.....D.....WE...Y.....F..FW......A....A.E....EV...V...K..E.....L...tAR....NA....GQ..PAhvFHGKAELNLADFSF.LPFLVRAHATLELLt.eGKH.D.nI...F.....E...K......FPIL....NQYLEKAL.AKPEIKSV................................
A0A165ANS3_9APHY/66-148              .............................................ay--VRFWIDH.V.S.KnVIP.GFH.R.LVQ..A...Q...-.EP..D.....K.....QK...A.....Y..LE......E....F.N....KL...F...R..T.....I....AE....K-....VK..GP..YFLGKQFSMIDVVV.APWVVRDY-IVRE-...---.-..-...-.....-...-......----....--------.--------hrgytr..........................
K9Z199_CYAAP/155-239                 .............................mfplqemnnrrgflqvvk---------.-.-.-.---.---.-.---..-...-...-.--..-.....-.....--...-.....-..--......-....-.-....EV...E...G..A.....L....--....SV....TD..SP..FFLDD-FSVADVVF.VPYVERMNASLYYY...KGY.S..L...R.....E...E......NPLL....SRWFSALE.ERSTYR--gt..............................
Q4CZ29_TRYCC/93-200                  ...............................................HRVEFFLGE.I.G.D.LVK.AYF.G.LVR..D...P...F.NE..E.....K.....RK...S.....V..DN......N....T.A....YI...E...D..I.....I....AE....HQ....GD..GP..YFLDDTFSMAEVMV.VPFLACFRPVLSYY...CGY.D..I...F.....H...N......APRL....KKMYVTSM.QRTTVKET................................
G4QF58_GLANF/109-200                 ........................................teafwgv---------.-.-.-.---.---.-.---..-...P...V.HE..E.....T.....KK...E.....V..KR......A....L.L....NG...M...Q..A.....L....SR....AA....SF..SP..YIAGDKMTAADIFF.MYSVSLASAVAKKL...FGI.D..L...F.....A...E......APGA....KELFAKLN.AMPEAR--ai..............................
A0A067BTL6_SAPPC/118-229             .....................................laqlaqakfe---------.-.-.-.-IG.PFY.A.LLR..Nq.dP...AkKD..E.....L.....EA...K.....I..EA......A....L.G....DL...E...K..I.....Y....RD....HAadfrAD..GP..YLLGADLSSAEINI.VPFLFRFKHVLSHY...RDF.D..I...T.....K...G......FPLV....TAAYEAAI.ARPAFK--lt..............................
A0A067BVQ3_SAPPC/117-226             ........................qlaqakleigpfygllrnqdpak---------.-.-.-.---.---.-.--K..E...G...F.EA..D.....I.....RE...T.....L..DE......L....E.K....IY...R...E..H.....A....AE....FR....AK..GP..YLFGDQLSSAEINI.IPFFFRFQIILKHY...RDF.E..L...L.....K...G......YPLL....TAAYEAAV.ERPAFKQT................................
K5UTW3_PHACS/122-223                 ......................................lwldyiskq---------.-.-.-.IVP.AYF.R.LIQ..A...Q...-.GE..Q.....N.....QT...T.....A..RE......E....Y.Y....KI...L...R..T.....F....AD....-M....VK..GP..YFLGEQFSLVDVAI.APFVVR-DAVLKEK...RGY.E..R...V.....D...V......SAKW....KEYADKVA.ARPSVV--kt..............................
Q70GE8_LEIMA/97-204                  ...............................................HQIEFFLAQ.V.G.D.FIA.AAH.G.LLR..D...P...L.SG..E.....K.....RK...A.....V..DD......N....A.A....YV...D...G..L.....L....AA....NQ....TT..GP..YYCDGEFTMADVAL.VPFLVRLKPALMYY...AGY.D..V...F.....C...K......APRM....KVLWAAAA.QRTSVRET................................
A0A068SC34_9FUNG/91-205              ..............................................a-EVRFVIEY.F.S.S.KIT.PLF.Y.FVL..R...N...M.TE..E.....G.....KK...E....yV..EKi...tiA....Y.K....RL...N...E..L.....L....LE....QA....AS..GP..YFLGDQYSLADIAI.APFLTRVLAVQKAYlkdIKF.D..V...I.....D...Q......SPRL....QQFFEGLL.TRSS----hadt............................
S2JI82_MUCC1/101-212                 ...............................................YAIEFYGSS.I.GsD.YNK.YLN.T.CGE..D...G...S.FR..H.....Y.....KM...I.....M..NT......H....L.F....RL...D...Q..L.....L....RA....QS....TT..GP..YFLGSEFTYADIGM.ASFVIRMLTFNKHM..lDGF.E..Fs.aL.....E...A......CPRV....AKYFEALI.SRPSVQET................................
T0PTI3_9STRA/60-156                  ........................................alllnqd---------.-.-.-.---.---.-.---..-...P...A.KK..D.....K....lEA...N.....L..RD......S....L.G....EL...E...K..I.....Y....RD....HAadfrAD..GP..YLLGADLSSAEISI.VPFLFHFKHVLGHY...RDF.D..V...T.....K...G......FPLL....TAAYEAAI.ARPAFK--rs..............................
T0PY11_9STRA/174-263                 ..........................................akmpa---------.-.-.-.---.---.-.---..-...-...L.EA..E.....M.....RA...S.....L..QG......L....E.R....IY...R...E..H.....A....AA....FR....AK..GP..YLLGDRFSSAEINI.MTFLFRFDILLQHY...RKV.R..V...L....gD...D......IPLL....SAALEASM.ARPA----falt............................
E1ZHD6_CHLVA/99-217                  .............................................ak--VRLFVDA.FsA.Q.LTP.ALF.G.LLR..A...A...D.AE..A.....Va..agKA...K.....L..ES......A....L.K....VL...D...A..F.....L....TQ....HGs..qEG..GD..YFLGPTYSLAEVAT.VGFVQRSLSALPAF...RGV.D..L...WelvrqN...K......LGRL....ERWMEASL.ARPSAQQT................................
Q70GE8_LEIMA/321-429                 ...............................................YEVGFFVEN.A.G.Y.FVG.GLM.S.WII..R...G...-.GE..D.....A.....KA...E.....L..QW......A....A.G....EL...E...Q..Q.....L....AK....HP...fGE..GP..FFGGKRMNAGDVAI.LPFLVRAKAFMPEF..sGGY.D..L...F.....A...H......FPLL....NVLAEAGM.AAPEAKA-v...............................
L8GFR3_ACACA/88-196                  ............................................yas---RFIVDQ.F.G.SqVIP.ALY.Q.LLR..N...QdrsQ.DD..K.....I.....KE...E.....I..TK......K....L.K....AL...L...D..L.....Y....SA....QA....GE..GP..YFLGQHISLADVAI.LPFIGRFAISLPHY...RDF.D..V...L.....A...V......DERL....KKWHD---.--------afgyakya........................
V5DBY4_TRYCR/317-426                 ...............................................YHVSFVESN.V.D.Y.FMD.AMF.S.LIK..D...P...K.NM..N.....A.....KE...E.....F..DW......A....A.G....EL...E...K..L.....L....AE....HQ...fGE..GP..FFGGASMNAADVSL.VSMLVHLKACTPDL..tEGQ.D..L...L.....A...N......YKLL....TAAAEAGL.TSEAGK--kv..............................
A0A0C9Z9N8_9HOMO/121-203             .....................................iwidhisktv---------.-.-.-.-VP.AWM.R.LLM..A...Q...-.-P..N.....E.....QE...K.....L..QT......A....L.N....EL...Y...E..G.....L....RK....LQr..eVK..GP..YFAGEQFTLVDVAL.VPWVVRD-HVLAEH...RGY.-..-...-.....-...-......----....--------.--------kred............................
K9RDG2_9CYAN/142-240                 ..........................llfrawcswlcypasssqqeq---------.-.-.-.---.---.-.---..-...-...-.--..R.....N.....RE...Q.....F..IQ......V....V.A....KI...E...Q..A.....L....AA....T-....-P..GP..YFLD-NFGIVDVIF.TPYVERMNASLYYY...KGY.S..M...R.....E...D......NPRF....NAWFAAME.TRPTYR--gt..............................
E0ULF3_CYAP2/145-239                 .................................awcnwlcyparsss---------.-.-.-.---.---.-.---..-...-...F.DQ..Q.....N.....RQ...K.....F..IN......V....V.Q....MV...E...D..A.....L....S-....-R....TE..GP..YFLE-QFGTVDVIF.TPYVERMNASLYYY...KGY.S..L...R.....E...E......NPHL....AAWFEAME.SRPTYR--gt..............................
T0R7R9_9STRA/121-229                 .......................laqakfeagpfyallrnkdpakka---------.-.-.-.---.---.-.---..-...-...-.--..E.....L.....EA...N.....L..HE......S....L.S....EL...E...K..I.....YrdhaAE....FR....SK..GP..YLLGDKFSSAELNI.VTFLFRFKHILKHY...RDF.D..I...L.....E...G......LPLL....SAALEASS.QRPAFKKT................................
#=GC SS_cons                         .............................................HHHHHHHHHHHTH.H.H.HHH.HHH.H.HHH..C--GC...C.HH..H.....H.....HH...H.....H..HH......H....H.H....HH...H...H..H.....H....HH....HT...TSS..SS..CCCCTC--HHHHHH.HHHHHHHHHHHHHH..TCT-.-..C...C.....T...T......-HHH....HHHHHHHH.TSHHHHCC-SS.............................
#=GC seq_cons                        .......................................................................t.hh...t.........pt..c.....t.....+p...p.....l..pp......s....h.s....tl...-...p..h.....l....sp....pt....ss..GP..aaLGsphShADlsl.lPFlhRhpshLtaa...pGa.-..l...h.....p...p......hPtL....pthhtAsh.tRsshp..................................
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