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Database: Pfam
Entry: Microvir_lysis
LinkDB: Microvir_lysis
Original site: Microvir_lysis 
#=GF ID   Microvir_lysis
#=GF AC   PF04517.16
#=GF DE   Microvirus lysis protein (E), C terminus
#=GF AU   Kerrison ND;0000-0002-1471-953X
#=GF SE   DOMO:DM04358;
#=GF GA   25.00 25.00;
#=GF TC   25.50 25.00;
#=GF NC   24.90 22.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12100551
#=GF RT   The Escherichia coli FKBP-type PPIase SlyD is required for the
#=GF RT   stabilization of the E lysis protein of bacteriophage phiX174. 
#=GF RA   Bernhardt TG, Roof WD, Young R; 
#=GF RL   Mol Microbiol 2002;45:99-108.
#=GF DR   INTERPRO; IPR007605;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   E protein causes host cell lysis by inhibiting MraY, a
#=GF CC   peptidoglycan biosynthesis enzyme.  This leads to cell wall
#=GF CC   failure at septation [1]. The N terminal transmembrane region
#=GF CC   matches the signal peptide model and must be omitted from the
#=GF CC   family.
#=GF SQ   9
#=GS Q2LMC7_9VIRU/35-74        AC Q2LMC7.1
#=GS VGE_BPAL3/35-74           AC P31280.1
#=GS A0A3Q7E883_SOLLC/164-193  AC A0A3Q7E883.1
#=GS Q2LM46_9VIRU/35-74        AC Q2LM46.1
#=GS W9B137_MYCCO/1-25         AC W9B137.1
#=GS Q2LLN3_BPPHX/35-74        AC Q2LLN3.1
#=GS LYS_BPPHS/35-74           AC P03639.3
#=GS VGE_BPG4/35-74            AC P03640.1
#=GS Q2LM36_9VIRU/35-74        AC Q2LM36.1
Q2LMC7_9VIRU/35-74                   ..HVLLWKAPSSPKILSMVLTSQLRPLNYSLLPCVYAPETLT....
VGE_BPAL3/35-74                      ..HASLWKARSLAKTLSMASSARLTPLSSSRTPCVLKQDSKK....
A0A3Q7E883_SOLLC/164-193             ge-----------KTESMVDESLQKPISCSRTPCIFF-----nkpk
Q2LM46_9VIRU/35-74                   ..PVLSWKVQSLPKTSLMVSNALLRPPNCSPLLFSFVPETKT....
W9B137_MYCCO/1-25                    ..---------------MASSVRLKPLNCSRLPCVYAQETLT....
Q2LLN3_BPPHX/35-74                   ..PASSWKALSLRKTLLMASSVRLRPLNCSRLPCVYAQETLT....
LYS_BPPHS/35-74                      ..PVSSWKALNLRKTLLMASSVRLKPLNCSRLPCVYAQETLT....
VGE_BPG4/35-74                       ..PVSSWKVLSLPKTSSMVLNAPLKPLNCSPSLFLFAPETKI....
Q2LM36_9VIRU/35-74                   ..PASSWKALSLRKTLLMASSVRLKPLSSSRTPCVLRPDSKK....
#=GC seq_cons                        ...s..WKs.SL.KT..MsSospL+PLNCSRhPCVas.EThp....
//
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