#=GF ID   RepB-RCR_reg
#=GF AC   PF10723.13
#=GF DE   Replication regulatory protein RepB
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   PRODOM_PD763888
#=GF GA   21.00 21.00;
#=GF TC   21.10 21.00;
#=GF NC   20.80 20.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0057
#=GF RN   [1]
#=GF RM   9409148
#=GF RT   Rolling-circle replication of bacterial plasmids. 
#=GF RA   Khan SA; 
#=GF RL   Microbiol Mol Biol Rev. 1997;61:442-455.
#=GF DR   INTERPRO; IPR019661;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is a family of proteins which regulate replication of
#=GF CC   rolling circle replication (RCR) plasmids that have a
#=GF CC   double-strand replication origin (dso). Regulation of
#=GF CC   replication of RCR plasmids occurs mainly at initiation of
#=GF CC   leading strand synthesis at the dso, such that Rep protein
#=GF CC   concentration controls plasmid replication [1].
#=GF SQ   64
#=GS A0A2G8ED54_9GAMM/1-82    AC A0A2G8ED54.1
#=GS A0A1J7D6E6_9GAMM/9-84    AC A0A1J7D6E6.1
#=GS Q326V9_SHIDS/1-83        AC Q326V9.1
#=GS G2H1Q1_9ENTR/3-77        AC G2H1Q1.1
#=GS G2H038_9ENTR/2-77        AC G2H038.1
#=GS A0A1I5BAB2_9GAMM/1-79    AC A0A1I5BAB2.1
#=GS A0A378BQ51_KLEPR/1-84    AC A0A378BQ51.1
#=GS A0A328TPE6_9GAMM/4-82    AC A0A328TPE6.1
#=GS J2DEV1_KLEPN/1-60        AC J2DEV1.1
#=GS A0A1I4US01_9PROT/1-68    AC A0A1I4US01.1
#=GS A8H1Z2_SHEPA/59-137      AC A8H1Z2.1
#=GS A0A0M2K4K4_9GAMM/1-78    AC A0A0M2K4K4.1
#=GS A0A859PWA5_9ENTR/1-81    AC A0A859PWA5.1
#=GS A0A1Z4LB06_NOSLI/1-58    AC A0A1Z4LB06.1
#=GS A0A6M8SU94_9NEIS/19-95   AC A0A6M8SU94.1
#=GS COPB_SHIFL/1-83          AC P62537.1
#=GS A6TI22_KLEP7/1-83        AC A6TI22.1
#=GS Q93GS8_SALTY/8-88        AC Q93GS8.1
#=GS A0A859PX74_9ENTR/1-83    AC A0A859PX74.1
#=GS A0A1W6BBE9_9GAMM/1-82    AC A0A1W6BBE9.1
#=GS A0A6I4VAY1_9GAMM/1-83    AC A0A6I4VAY1.1
#=GS A0A443W2Q2_9ENTR/1-83    AC A0A443W2Q2.1
#=GS Q326M6_SHIDS/1-81        AC Q326M6.1
#=GS A0A377YW50_KLEPO/1-83    AC A0A377YW50.1
#=GS A0A0H3GW35_KLEPH/7-87    AC A0A0H3GW35.1
#=GS A0A2I8QDY9_9ENTR/1-70    AC A0A2I8QDY9.1
#=GS A0A2J4Y056_9ENTR/1-83    AC A0A2J4Y056.1
#=GS A0A1Z4C4L4_9GAMM/9-81    AC A0A1Z4C4L4.1
#=GS A0A6I4VJT2_9GAMM/1-83    AC A0A6I4VJT2.1
#=GS A0A663BJG6_9ENTR/1-83    AC A0A663BJG6.1
#=GS A0A0M2KAP0_9GAMM/1-79    AC A0A0M2KAP0.1
#=GS A0A2U8I8Z3_9GAMM/3-77    AC A0A2U8I8Z3.1
#=GS A0A3A9GUY4_9FIRM/7-74    AC A0A3A9GUY4.1
#=GS A0A6I4VDL7_9GAMM/1-82    AC A0A6I4VDL7.1
#=GS A0A222FLG1_9GAMM/1-63    AC A0A222FLG1.1
#=GS A0A7Y7BBF8_STRMO/1-81    AC A0A7Y7BBF8.1
#=GS A0A328THI2_9GAMM/19-100  AC A0A328THI2.1
#=GS A0A415RBK2_9FIRM/1-55    AC A0A415RBK2.1
#=GS A0KKI4_AERHH/6-74        AC A0KKI4.1
#=GS F0IHS3_9FLAO/36-96       AC F0IHS3.1
#=GS A0A7H9BFT6_9NEIS/2-62    AC A0A7H9BFT6.1
#=GS A0A6M8UK41_9GAMM/1-82    AC A0A6M8UK41.1
#=GS A0A8J7L430_9NOST/1-44    AC A0A8J7L430.1
#=GS A0A249WS89_9ENTR/1-82    AC A0A249WS89.1
#=GS D2TV77_CITRI/1-83        AC D2TV77.1
#=GS R6T165_9FIRM/3-61        AC R6T165.1
#=GS A0A120CTL8_HYPSL/24-91   AC A0A120CTL8.1
#=GS A0A0M2KAN3_9GAMM/1-84    AC A0A0M2KAN3.1
#=GS B2VB58_ERWT9/1-77        AC B2VB58.1
#=GS A0A653BYM7_CALMS/1-81    AC A0A653BYM7.1
#=GS A0A1N6VH77_9GAMM/13-77   AC A0A1N6VH77.1
#=GS A0A8J7GU61_9ENTR/1-76    AC A0A8J7GU61.1
#=GS A0A1E7YYM4_9GAMM/1-83    AC A0A1E7YYM4.1
#=GS A0A2V1H6Q6_9GAMM/1-79    AC A0A2V1H6Q6.1
#=GS A0A653CSB8_CALMS/1-80    AC A0A653CSB8.1
#=GS A0A1I0WEM7_9FIRM/1-59    AC A0A1I0WEM7.1
#=GS C4IEW2_CLOBU/1-54        AC C4IEW2.1
#=GS A0A6C2CJ07_9RHOO/2-70    AC A0A6C2CJ07.1
#=GS A0A377YTM9_KLEPO/1-83    AC A0A377YTM9.1
#=GS D4EA89_SEROD/1-60        AC D4EA89.1
#=GS A0A1G6EPM5_9FIRM/1-53    AC A0A1G6EPM5.1
#=GS COPB_ECO57/1-83          AC Q7BSX2.1
#=GS Q7ARH5_YERPE/1-82        AC Q7ARH5.1
#=GS F7V1X3_CLOSS/1-49        AC F7V1X3.1
A0A2G8ED54_9GAMM/1-82               .................mpqqqs-----TAAQPKQ..KRTYRKGNPLSDADK....Q.RLS....I.AR.K......K.E.SR.....K...EIKVFVEPEIKALLMDMCKQDGLNQADILKQLIEKEAR---crg........
A0A1J7D6E6_9GAMM/9-84               ..................qqekk-----------Q..KREYRKGAPLTQVEH....N.KRL....V.AK.R......S.V.SH.....K...ILRAFVPKDIVEQFKYTCHAQGETMQDVIAELMEAY-----ieknrg.....
Q326V9_SHIDS/1-83                   .......................MSQTENAVTSSLsqKRFVRRGKPMTDSEK....Q.MAA....V.AR.K......R.L.TH.....K...EIKVFVKNPLKDLMVEYCEREGITQAQFVEKIIKDELQRL-d..........
G2H1Q1_9ENTR/3-77                   .................eqnekk-----------P..KREYRKGNPLTLTER....T.KRY....K.DK.Q......K.K.NN.....R...EMRLFIPTDLGNQFTDHCREIKKSRSEVVSKLIEDY-----iksv.......
G2H038_9ENTR/2-77                   .................teqnek-----------K..KREYRLGNPLTLTEY....T.NRY....R.DR.K......K.E.NN.....R...EMRLFIPIDLGNRFTEHCREIGKSRSEIVSNLIEDYIQ---svc........
A0A1I5BAB2_9GAMM/1-79               .......................MSQAINAATSSS..KRAYRKGNPLSVSER....Q.QAL....M.ER.R......K.E.TH.....K...EIKVYVPTVLKERLQNLCEAEGVSQAEMISRLIAD------tcvp.......
A0A378BQ51_KLEPR/1-84               .......................MSQIDNAVTSSSkpKRPYRKGQPLSVSER....K.LRS....V.SR.K......R.D.TH.....K...AVTVFIQNAKKAMLDDLCSKSNMTQAEIIELLIERESEQR-nk.........
A0A328TPE6_9GAMM/4-82               ....mmdeekdavrrkvgkprky------------..---------ANRSER....Q.AAH....V.ENlK......R.K.DL.....K...EIQAYVLPEVKDILLSVCEAIGKTQSELLSEILV-------rfaecr.....
J2DEV1_KLEPN/1-60                   .......................------------..---------MTDSEK....Q.MAA....V.AR.K......R.L.TH.....K...EIKVFVKNPLKDLMVEYCEREGITQAQFVEKIIKDELQRL-d..........
A0A1I4US01_9PROT/1-68               ......................m------------..--------PLTNAEK....Q.KLY....R.ER.HlsfsesH.E.PL.....C...RLQAFVQPYTFNNVTRISRASGLTKREVIEKAINDLA----erld.......
A8H1Z2_SHEPA/59-137                 qtsnssveatvfiksfagnmyka------------..-------------HK....A.R--....L.YR.K......K.LgAK.....K...MLNVAITPKHMQNLEYICKSQGMQKNKVIEMMIEGSLQH--lin........
A0A0M2K4K4_9GAMM/1-78               ......maedegavrgtkvgrpr------------..-------KYETKSDK....Q.RAY....I.TQ.K......L.Q.TK.....V...QTKVLLSPDGRDTLNKLCKLRGVTQGELVTELIKKY-----asev.......
A0A859PWA5_9ENTR/1-81               .......................MTQLMNSEKASEitKRPYRKGNPLTGAEK....Q.KAA....I.AR.K......R.I.TH.....K...ELKVFIEPETKDLLLDICAKNGLTQSELVSKLIEQEAKK--...........
A0A1Z4LB06_NOSLI/1-58               .............msdtaverfs------------..---------------....-.NLA....T.ST.K......K.R.TL.....K...RITIDLTSDEAENLEKYCEQTGKTATDVIEELIR-------sl.........
A0A6M8SU94_9NEIS/19-95              ...............kkrgrpai------------..-----HGKPMSAAER....K.RRSrsmqV.GR.A......T.R.DHnqrlpK...ALSVEIDASLHQRLKRYCEANGMTQIETLEQLIQ-------tlp........
COPB_SHIFL/1-83                     .......................MSQTENAVTSSLsqKRFVRRGKPMTDSEK....Q.MAA....V.AR.K......R.L.TH.....K...EIKVFVKNPLKDLMVEYCEREGITQAQFVEKIIKDELQRL-d..........
A6TI22_KLEP7/1-83                   .......................MSRSADKTTSSTnaKRAYRKGKPMSASER....Q.LAA....I.AR.K......R.E.TH.....K...EVKVFVKNPLKDVMIAVCEEEGLTQAQFIEKLLERELTE--rg.........
Q93GS8_SALTY/8-88                   .......................MSQIENAVTSSS..KRIYRKGNPLSSAEK....K.RLS....I.SR.K......K.T.TH.....K...ELNVFIQNIHKESLQQLCEETGTTQAQMIELLIEREMAKR-a..........
A0A859PX74_9ENTR/1-83               .......................MSQSTHAAPSSSknKRPYRKGNPLTPSER....Q.QAL....V.AR.R......K.D.TH.....K...EIRVYVQSALKEDFQRLCEAEGLTQTEMLEELIKTASARL-a..........
A0A1W6BBE9_9GAMM/1-82               ...................mspr-----DSVTSAPekKRTRNREQPTPHKDR....V.RAY....K.AR.K......R.E.TH.....K...EINVFVRPEVKEVLVKLCELKGITQADLLEMMIEAEAR---nse........
A0A6I4VAY1_9GAMM/1-83               .......................MSQAVNAATSSSkeKRAYRKGNPMSATER....Q.LAA....I.SR.K......R.E.TH.....K...EMNVFIRNPMKDQLLHLCEQEGLTQGEMIEKLIQIETERR-g..........
A0A443W2Q2_9ENTR/1-83               .......................MSRPADKTTSSAnaKRAYRKGKPMSASER....Q.LAA....I.AR.K......R.E.TH.....K...EVKVFVKNPLKDVMIAVCEEEGLTQAQFIERLLERELTE--rg.........
Q326M6_SHIDS/1-81                   .......................MSQIENAVTSSP..KRIYRKGNPLTGAEK....Q.RIS....V.SR.K......K.G.TH.....K...AINVFIQSELKDDLTQLCKDSGLTQKEMIEHWILKEKAA--vd.........
A0A377YW50_KLEPO/1-83               .......................MSQTENAVTSSSgaKRAYRKGKPLSEAER....Q.RAA....S.AR.K......R.S.VC.....K...EIKVFVRPELKNYLTSLCAEEGVTQAELIERLIEKEACH--rn.........
A0A0H3GW35_KLEPH/7-87               .......................MSQVVNGVTSSS..KRPYRKGNPLSAADK....Q.RSS....V.AK.K......R.A.TH.....K...EVKVFLEPQLKEILMKMCHDDGLTQAEVLSRLIHREALA--rn.........
A0A2I8QDY9_9ENTR/1-70               ....................mnr------------..--VTERQEQKSNPEF....Q.REY....R.NR.I......R.E.TH.....D...QLNLYLPKDAKRMLIEITKVKKLTQAEVIEFLVKS------yydglk.....
A0A2J4Y056_9ENTR/1-83               .......................MSQIDNAVTSSSkdKRVYRKGSPMSASEK....Q.MAA....V.AR.K......R.V.TH.....K...EIKVFVRNPLKDILIDLCSRDGITQAQLVEKLLEKEFKA--qg.........
A0A1Z4C4L4_9GAMM/9-81               .................tqdmlk------------..------EPPKTNAER....Q.KAY....ReKR.K......S.L.DS.....Q...RLEVFIDKGVSDMLADMVGAAGESQKAILTALIEKEYKRL-yavk.......
A0A6I4VJT2_9GAMM/1-83               .......................MSHIENTVISSWkvKRTYRKGNPMSASEK....Q.LAS....I.AR.K......R.I.TH.....K...EIKVFVRNPLKDCMVKLCKAEGLTQAEFIEKLIEQKLKQ--lg.........
A0A663BJG6_9ENTR/1-83               .......................MSRPADKTTSSAnaKRAYRKGKPMSASER....Q.LAA....I.AR.K......R.E.TH.....K...EVKVFVKNPLKDVMIAVCEEEGLTQAQFIERLLERELTE--rg.........
A0A0M2KAP0_9GAMM/1-79               .......................MSQAVNAATSSS..KRAYRKGNPLSVSER....Q.QAL....M.ER.R......K.E.TH.....K...EIKVYVPTVLKERLQNLCEAEGVSQAEMISRLIAD------agip.......
A0A2U8I8Z3_9GAMM/3-77               ..................epnek-----------K..KREYRLGNPLTQSEY....N.KRF....E.ER.K......T.K.EN.....K...SIRMFVPYELAEDFKRYCKGNGLTMQDTVTELLREFM----sdkk.......
A0A3A9GUY4_9FIRM/7-74               ...............ekeviiis------------..--------PVSDAKK....R.---....-.AN.K......K.W.TE.....KnytQVKLSMPNEEAETLDNYCKEKGHTKAGFIRQAIKDKMAR--ne.........
A0A6I4VDL7_9GAMM/1-82               .......................MSKILNVITSSS..KRIYKKGKPLSVAER....Q.QAL....T.KR.R......K.E.TH.....K...EIKVYVPLALKKSLCDLCQSEGISQAEMISILISD------asiimqr....
A0A222FLG1_9GAMM/1-63               ......................m------------..--------PLSEAER....Q.KRY....R.QR.V......Q.AkGK.....K...RYQVLVSSQVAEHAQELCERLDCSKGELFSRLIEDEYQR--va.........
A0A7Y7BBF8_STRMO/1-81               .......................MSQTENAVTSSSgtKRAYRKGNPLTLAER....Q.QAS....L.AR.K......R.A.TH.....K...ELRVFIPAALKAQLQEMCDAEGVTQAEMIAELIKQKS----af.........
A0A328THI2_9GAMM/19-100             ..........mpttqpataqlkh------------..KQTRNRKNPMSDSER....Q.LSY....V.AR.K......R.E.AL.....K...EIKIFVEPELKKALMLMCQDEGLTQADILQRLIKHEA----elkg.......
A0A415RBK2_9FIRM/1-55               ......................m------------..--------------K....R.VIP....M.AR.Q......K.K.DA.....K...ILNIRLATPVSDKLESFCKESGQTKTVAVERFLTKC-----ldey.......
A0KKI4_AERHH/6-74                   ................kvssaqd------------..-----------NAER....Q.RQH....V.KR.K......Q.E.TH.....S...RLQCWISNRHAERLAMLGLQLEDSQASLIEQAID-------llyqheleqkq
F0IHS3_9FLAO/36-96                  .................ymylck------------..--------------K....I.NRS....M.AR.E......R.I.KG.....K...ALNIRVSEEFITLLKLLSEKKGMSQANLIEYLVRKEADA--iq.........
A0A7H9BFT6_9NEIS/2-62               .aerkrrsralqltratqdhqqr------------..---------------....-.---....-.--.-......-.-.LP.....K...ALSVEIDASLHRRFKRYCESRGLTQAQGMEQIL--------ssl........
A0A6M8UK41_9GAMM/1-82               .......................MSQSVTAVTTSSgsKRPYRKGNPLSASEK....Q.QAA....V.AR.K......K.L.TH.....K...ELKIFVRNPIKDRLLIECEKEGLTQAEYIERVLQQ------afdes......
A0A8J7L430_9NOST/1-44               .....................ms------------..---------------....-.---....-.--.K......K.N.TD.....K...QINVDLALDEAKTLEKYCKETGKEEKEVIKELVRK------l..........
A0A249WS89_9ENTR/1-82               .......................MSQVVSAVTSSTkaKRSYRKGSPRSAVER....Q.QSH....L.AR.K......K.E.TH.....K...EMRVYVTSEIKDEFRLMCETKGVTQSEMIEKLIKEAV----nqh........
D2TV77_CITRI/1-83                   .......................MSQTENAVTSSSgaKRAYRKGNPLSDAEK....Q.RLS....V.AR.K......R.A.SF.....K...EVKVFLEPKYKAMLMQMCHEDGLTQAEVLTALIKSEAQKR-c..........
R6T165_9FIRM/3-61                   .........ytkasnkavqkysa------------..---------------....-.---....-.--.-......-.K.TY.....D...QIKVLVKKGEREEIKNYAESQGMSLNGYINKLIKDDMK---tad........
A0A120CTL8_HYPSL/24-91              ....erraraerragmavndrrr------------..---------------....-.---....-.-K.K......R.E.TR.....N..tPLNTRVRKSVSDLAKALCDAEGISQADLLEQLIEKAA----ktkg.......
A0A0M2KAN3_9GAMM/1-84               .......................MSQATNAATSSSkeKRAYRKGNPMSATER....Q.LAA....I.AR.K......R.E.TH.....K...EVNVFIRNPMKAQLLHLCKQEGLTQGEMIEKLIQIETKRR-ge.........
B2VB58_ERWT9/1-77                   .........mpqtdnptqsevnp------------..---SRK-APLTARER....K.MRS....V.AR.K......R.E.TH.....S...PLNVFIHNSTKQKLDEMCKKSGLTQAEAIEHLIK-------gmnsv......
A0A653BYM7_CALMS/1-81               .......................MSQAANAATSSS..KRPYRKGNPLSDADK....Q.RAS....V.AR.K......R.A.TH.....K...EVKVFLEPQLKELLMTMCQEDGLTQAEILARLIEREAQAR-n..........
A0A1N6VH77_9GAMM/13-77              ...............aekaevkd------------..-----------NAER....Q.RDH....V.RR.K......Q.E.TH.....T...RLQCWISRRHGDRLAELTARLEDSQASLIEQAID-------llyaqe.....
A0A8J7GU61_9ENTR/1-76               ...............mtevkgav-----------R..KRVGRPRKFQSDAEK....L.KAH....R.DS.M......M.K.IK.....S...QVRVFLDPLDKKSLVEMCEENGMTQGEMITQLIRS------airn.......
A0A1E7YYM4_9GAMM/1-83               .......................MSQTGNAETSSSkeKRQYRKGNPMSPVQR....Q.KAH....V.AK.L......K.E.TH.....K...EMRVYVEKSLKAELELLCATKGVTQSEMIEKLIHDAV----secr.......
A0A2V1H6Q6_9GAMM/1-79               .......................MSQ-KNSVTSS-..KREYRKGNPLSGAEK....Q.RVS....V.AR.K......R.A.RY.....K...EVKVFIDPQLKAYLVGMCAQDGATQAELVGRLIEREAV---srs........
A0A653CSB8_CALMS/1-80               .......................MSQAVNAATSSP..KRAYRKGNPLSVSER....Q.QAL....M.ER.R......K.E.TH.....K...EIKVYVPTVLKERLQNLCEAEGVSQAEMISRLIADAAQ---eg.........
A0A1I0WEM7_9FIRM/1-59               ....................mps------------..-------------ES....Q.NKA...tA.KY.K......K.R.NY.....K...RIPLEVKNEHYEIIKAHCEELGKPVNTFIKELIFKELN---ik.........
C4IEW2_CLOBU/1-54                   ......................m------------..---------------....-.---....-.AR.Q......K.K.DG.....V...YINYYIRKDIKEKLDEYCEEVGQTNTLALERILGQ------fldkyfeekk.
A0A6C2CJ07_9RHOO/2-70               ...............yinqgeit------------..---------MTTNER....QsRYR....A.KR.R......T.E.GD.....K...RLSIWVKKDVADALLTVANTLSVTQKHLIEKLLLSAIAT--lk.........
A0A377YTM9_KLEPO/1-83               .......................MSQTENAVTSSLsqKRFVRRGKPMTDSEK....Q.MAA....V.AR.K......R.L.TH.....K...EIKVFVKNPLKDLMVEYCEREGITQAQFVEKIIKDELQRL-d..........
D4EA89_SEROD/1-60                   .......................------------..---------MSDSER....Q.QAA....V.AR.K......R.A.TH.....K...EVKIFVRNSLKHRLVEMCEADGVTQAEMIEKWIELEYQSR-s..........
A0A1G6EPM5_9FIRM/1-53               .....................mp------------..---------------....-.---....-.-R.Q......K.K.DG.....V...NINYFIRRDVKEKLDKYCDDVGQTATMAIERILNEYLT---kyfedk.....
COPB_ECO57/1-83                     .......................MSQTENAVTSSSgaKRAYRKGNPLSDAEK....Q.RLS....V.AR.K......R.A.SF.....K...EVKVFLEPKYKAMLMQMCHEDGLTQAEVLTALIKSEAQKR-c..........
Q7ARH5_YERPE/1-82                   .......................MSQIENAVTSSS..KRAYRKGNPLTGAEK....Q.RMS....V.SR.K......K.E.TH.....K...AINVFIQNDLKNELLQLCEDSGLTQTEMIERWIQREKAAR-tn.........
F7V1X3_CLOSS/1-49                   ...................mprp------------..---------------....-.---....-.--.-......K.K.DA.....H...VLNIKLESSVYEDLDRFCEETGVTKTAAVEKILRS------flddy......
#=GC seq_cons                       ........................................hphtpPhosuE+....Q.pth....h.uR.K......+.p.T+.....K...clpValpsslK-tLhphCcppGlTQu-hlccLIccth....t..........
//