GenomeNet

Database: Pfam
Entry: WD40_alt
LinkDB: WD40_alt
Original site: WD40_alt 
#=GF ID   WD40_alt
#=GF AC   PF14077.5
#=GF DE   Alternative WD40 repeat motif
#=GF AU   Weichenberger CX
#=GF SE   Joint Center of Structural Genomics (JCSG)
#=GF GA   25.00 25.00;
#=GF TC   26.30 59.20;
#=GF NC   24.20 24.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10322433
#=GF RT   The WD repeat: a common architecture for diverse functions.
#=GF RA   Smith TF, Gaitatzes C, Saxena K, Neer EJ;
#=GF RL   Trends Biochem Sci. 1999;24:181-5.
#=GF DR   INTERPRO; IPR026987;
#=GF CC   WD repeats are short subdomains of about 40 amino acids and fold
#=GF CC   into 4 antiparallel beta hairpins. This domain here has been
#=GF CC   detected on the C-terminus of WD repeat-containing protein 18
#=GF CC   during target selection by the Joint Center for Structural
#=GF CC   Genomics.
#=GF SQ   76
#=GS A0A091SAG1_MERNU/185-225  AC A0A091SAG1.1
#=GS F6V3G3_MONDO/629-676      AC F6V3G3.2
#=GS F1NYU3_CHICK/383-430      AC F1NYU3.2
#=GS L5L6M3_PTEAL/383-430      AC L5L6M3.1
#=GS M3W7H8_FELCA/392-437      AC M3W7H8.1
#=GS M3YCZ6_MUSPF/383-430      AC M3YCZ6.1
#=GS A0A091N400_CARIC/314-354  AC A0A091N400.1
#=GS A0A151P0I2_ALLMI/339-386  AC A0A151P0I2.1
#=GS A0A091NBM1_9PASS/317-357  AC A0A091NBM1.1
#=GS G3HF54_CRIGR/926-972      AC G3HF54.1
#=GS U3KQC1_HUMAN/345-392      AC U3KQC1.1
#=GS G3QEA3_GORGO/383-430      AC G3QEA3.1
#=GS G5C5Y0_HETGA/383-427      AC G5C5Y0.1
#=GS G1U0L4_RABIT/1-44         AC G1U0L4.1
#=GS W5LHM3_ASTMX/383-430      AC W5LHM3.1
#=GS WDR18_RAT/383-429         AC Q499N3.1
#=GS A0A0Q3Q2U4_AMAAE/383-430  AC A0A0Q3Q2U4.1
#=GS A0A091I8U2_CALAN/314-354  AC A0A091I8U2.1
#=GS K7F9U6_PELSI/319-366      AC K7F9U6.1
#=GS K7EIR0_HUMAN/362-407      AC K7EIR0.1
#=GS A0A093I4F0_PICPB/309-349  AC A0A093I4F0.1
#=GS W5PKA2_SHEEP/369-416      AC W5PKA2.1
#=GS F1PDD1_CANLF/317-364      AC F1PDD1.2
#=GS U3IH79_ANAPL/298-345      AC U3IH79.1
#=GS G1QK67_NOMLE/347-394      AC G1QK67.1
#=GS A0A091J8R2_9AVES/314-354  AC A0A091J8R2.1
#=GS G3PJ76_GASAC/380-427      AC G3PJ76.1
#=GS A0A087VQ78_BALRE/314-354  AC A0A087VQ78.1
#=GS L5LSJ1_MYODS/383-430      AC L5LSJ1.1
#=GS G3TIL8_LOXAF/383-430      AC G3TIL8.1
#=GS L8Y4K8_TUPCH/357-404      AC L8Y4K8.1
#=GS S7PCP6_MYOBR/383-430      AC S7PCP6.1
#=GS A0A093BRN8_CHAPE/310-350  AC A0A093BRN8.1
#=GS G3PJ85_GASAC/380-426      AC G3PJ85.1
#=GS A0A0A0MX88_PAPAN/395-442  AC A0A0A0MX88.1
#=GS A0A087R367_APTFO/314-354  AC A0A087R367.1
#=GS A0A0D9RJC3_CHLSB/383-430  AC A0A0D9RJC3.1
#=GS H3CGK9_TETNG/385-432      AC H3CGK9.1
#=GS WDR18_BOVIN/383-430       AC Q3SZD4.1
#=GS H3B7I8_LATCH/383-430      AC H3B7I8.1
#=GS WDR18_MOUSE/383-429       AC Q4VBE8.1
#=GS U3KHP5_FICAL/323-370      AC U3KHP5.1
#=GS G5E7R9_MELGA/346-393      AC G5E7R9.1
#=GS D2HMD2_AILME/383-430      AC D2HMD2.1
#=GS H2L323_ORYLA/382-429      AC H2L323.1
#=GS F7H748_MACMU/342-389      AC F7H748.1
#=GS WDR18_HUMAN/383-430       AC Q9BV38.2
#=GS G3PJ88_GASAC/380-427      AC G3PJ88.1
#=GS F1S6R5_PIG/383-430        AC F1S6R5.1
#=GS G7PY96_MACFA/383-430      AC G7PY96.1
#=GS Q28IR7_XENTR/381-428      AC Q28IR7.1
#=GS H2L319_ORYLA/353-400      AC H2L319.1
#=GS A0A099Z969_TINGU/278-318  AC A0A099Z969.1
#=GS F6VKZ1_MONDO/383-430      AC F6VKZ1.1
#=GS A0A093H921_STRCA/314-354  AC A0A093H921.1
#=GS A0A093QDU0_9PASS/313-353  AC A0A093QDU0.1
#=GS H0X9K9_OTOGA/383-430      AC H0X9K9.1
#=GS A0A091FP11_9AVES/314-354  AC A0A091FP11.1
#=GS A0A0A0MQU0_HUMAN/380-427  AC A0A0A0MQU0.1
#=GS A0A087XUS3_POEFO/414-461  AC A0A087XUS3.2
#=GS F1LR39_RAT/383-429        AC F1LR39.2
#=GS H2NWS2_PONAB/367-414      AC H2NWS2.2
#=GS I3JA47_ORENI/382-429      AC I3JA47.1
#=GS H0YQW8_TAEGU/315-355      AC H0YQW8.1
#=GS S9XPC9_CAMFR/455-488      AC S9XPC9.1
#=GS WDR18_DANRE/383-430       AC Q68EI0.1
#=GS M7B7B0_CHEMY/288-335      AC M7B7B0.1
#=GS W5M196_LEPOC/385-432      AC W5M196.1
#=GS A0A0A0ASL4_CHAVO/314-354  AC A0A0A0ASL4.1
#=GS V8NEB4_OPHHA/264-311      AC V8NEB4.1
#=GS F6QFH9_MACMU/383-430      AC F6QFH9.1
#=GS G3VIY2_SARHA/383-430      AC G3VIY2.1
#=GS A0A091VEE8_NIPNI/314-354  AC A0A091VEE8.1
#=GS I3MXU1_ICTTR/383-430      AC I3MXU1.1
#=GS H2QET7_PANTR/335-382      AC H2QET7.1
#=GS G1PIU9_MYOLU/313-360      AC G1PIU9.1
A0A091SAG1_MERNU/185-225             ....MYSTREKNLVGDQEHLTIQVSELEEEVSTLRKINKNLFDFS-------..
F6V3G3_MONDO/629-676                 ....MCTTLDKNSLGDQEQLKIRVTELEEEVNTLRKINKDLFDFSSHIITK-l.
F1NYU3_CHICK/383-430                 ....MCSTREKNLMGDQEHLTIQVSELEEEVSTLRKINKNLFDFSARIITKP..
L5L6M3_PTEAL/383-430                 ....LCSTMEKSVLGGQDQLRIRVTELEDEVQNLRKINRDLFDFSTHIITRP..
M3W7H8_FELCA/392-437                 pvlp------QSVLGGQDQLRIRVAELEDEVRNLRKVNRDLFDFSTRIITRP..
M3YCZ6_MUSPF/383-430                 ....MSSTMEKSVLGGQDQLRVRVAELEDEVRNLRKVNRDLFDFSTRVITRP..
A0A091N400_CARIC/314-354             ....MYSTREKNLVGDQEHLTIQVSELEEEVSTLRKINKNLFDFS-------..
A0A151P0I2_ALLMI/339-386             ....MCSTREKNLMGDQEQLKIQVTDLEEEVQTLRKINKNLFEFSARFLTK-s.
A0A091NBM1_9PASS/317-357             ....MYSTREKNLVGDQEHLTIQVSELEEEVSTLRKINKNLFDFS-------..
G3HF54_CRIGR/926-972                 ...l-SGYLAKNMLGNQ-MLPARVLELEEEVRSLRKINRDLFDFSTRIITRP..
U3KQC1_HUMAN/345-392                 ....LCSTMEKSVLGGQDQLRVRVTELEDEVRNLRKINRDLFDFSTRFITRP..
G3QEA3_GORGO/383-430                 ....LCSTMEKSVLGGQDQLRVRVTELEDEVRNLRKINRDLFDFSTRFITRP..
G5C5Y0_HETGA/383-427                 ....MSSTLEKS---SQDQLRVRVSELEDEVRNLRKINRDLFDFSTHIITRP..
G1U0L4_RABIT/1-44                    ....----MEKSVLGGQDRLRVRVSTLEDEVRSLRKISRDLFHFCTCIITWP..
W5LHM3_ASTMX/383-430                 ....MCAVTDKSVFGDGENTKVRVSELEEEVRTLKKINKDLYEFSTQLLTKP..
WDR18_RAT/383-429                    ....LSGYLEKNMLGSQ-MLPVRVFELEEEVRSLRKINRDLFDFSTRIITRP..
A0A0Q3Q2U4_AMAAE/383-430             ....MYSTREKNLVGDQEHLTIQVSELEEEVSTLRKINKNLFDFSARIITKP..
A0A091I8U2_CALAN/314-354             ....MYSTREKNLVGDQEHLTIQVSELEEEVSTLRKINKNLFDFS-------..
K7F9U6_PELSI/319-366                 ....MCSTREKNLMGDQEQLKIQVTELEDEVSTLRKINKNLFDFSARIITK-s.
K7EIR0_HUMAN/362-407                 .glh-----QQSVLGGQDQLRVRVTELEDEVRNLRKINRDLFDFSTRFITRP..
A0A093I4F0_PICPB/309-349             ....MYSTREKNLVGDQEHLTIQVSELEEEVSTLRKINKNLFDFS-------..
W5PKA2_SHEEP/369-416                 ....MSSTLEKNVLGGQDQLRIRVTELEDEVRNLRKINRDLFDFSTRIITHP..
F1PDD1_CANLF/317-364                 ....MSSTMEKSVLGGQDQLRIRVAELEDEVHNLRKVNRDLFDFSTRIITRP..
U3IH79_ANAPL/298-345                 ....MCSTREKNLVGDQEHLTIQVSELEEEVSTLRKINKNLFDFSARIITKP..
G1QK67_NOMLE/347-394                 ....LGSTMEKSVLGGQDQLRVRVTELEDEVRNLRKINRDLFDFSTRFITRP..
A0A091J8R2_9AVES/314-354             ....MYSTREKNLVGDQEHLTIQVSELEEEVSTLRKINKNLFDFS-------..
G3PJ76_GASAC/380-427                 ....MNAVTDKSVFGDGENTKVRVAELEEEVQTLKKVNKDLYDFSSQLLTKP..
A0A087VQ78_BALRE/314-354             ....MYSTREKNLVGDQEHLTIQVSELEEEVSTLRKINKNLFDFS-------..
L5LSJ1_MYODS/383-430                 ....MCSTMEKNVLGGQDQLRIRITELEDEVQNLRKINRDLFDFSTRIITRP..
G3TIL8_LOXAF/383-430                 ....MCSTMEKSVLGGQDQLRIRVTELEDEVRNLRKINRDLFDFSTRVITRP..
L8Y4K8_TUPCH/357-404                 ....MCGTSEKNVLGGQDQLRVRVTELEDEVRNLRKVNRDLFDFSTRIITRP..
S7PCP6_MYOBR/383-430                 ....MCSTMEKNVLGGQDQLRIRITELEDEVQNLRKINRDLFDFSTRIITRP..
A0A093BRN8_CHAPE/310-350             ...c-CIFLSQNLVGDQEHLTIQVSELEEEVSTLRKINKNLFDFS-------..
G3PJ85_GASAC/380-426                 ....MNAVTDKSVFGDGENTKVRVAELEEEVQTLKKVNKDLYDFSSQLL---kh
A0A0A0MX88_PAPAN/395-442             ....LCSTMEKSVLGGQDQLRVRVTELEDEVRNLRKINRDLFDFSTRFITRP..
A0A087R367_APTFO/314-354             ....MYSTREKNLVGDQEHLTIQVSELEEEVSTLRKINKNLFDFS-------..
A0A0D9RJC3_CHLSB/383-430             ....LCSTMEKSVLGGQDQLRVRVTELEDEVRNLRKINRDLFDFSTRFITRP..
H3CGK9_TETNG/385-432                 ....MNAVTDKSVFGDGENTKMRVAELEDEVHTLKKINKDLYEFSSQLLTKP..
WDR18_BOVIN/383-430                  ....MSSTLEKNVLGGQDQLRIRVTELEDEVRNLRKINRDLFDFSTRIITHP..
H3B7I8_LATCH/383-430                 ....MCSATDKNVFGDGENTKVRIAELEDEVKTLKKINKDLYDFSTQILTKQ..
WDR18_MOUSE/383-429                  ....LSSYLEKNMLGSQ-MLPARVFDLEDEVRSLRKINRDLFDFSTRIITRP..
U3KHP5_FICAL/323-370                 ....MYSTREENLVGDQEHLTIQVSELEEEVSNLRKINKDLFDFSTRIITKP..
G5E7R9_MELGA/346-393                 ....MCSTREKNLMGDQEHLTIQVSELEEEVSTLRKINKNLFDFSARIITKP..
D2HMD2_AILME/383-430                 ....MSSTMEKSVLGGQDQLRIRVAELEDEVRNLRKVNRDLFDFSTRIITRP..
H2L323_ORYLA/382-429                 ....MTAVTDRSVCGDGESTKVHVAELKEEVQILKKVNRELYEFSSQLLTKP..
F7H748_MACMU/342-389                 ....LCSTMEKSVLGGQDQLRVRVTELEDEVRNLRKINRDLFDFSTRFITRP..
WDR18_HUMAN/383-430                  ....LCSTMEKSVLGGQDQLRVRVTELEDEVRNLRKINRDLFDFSTRFITRP..
G3PJ88_GASAC/380-427                 ....MNAVTDKSVFGDGENTKVRVAELEEEVQTLKKVNKDLYDFSSQLLSKP..
F1S6R5_PIG/383-430                   ....MCSTMEKNVLGGQDQLRIRVTELEDEVRNLRKINRDLFDFSTHIITRP..
G7PY96_MACFA/383-430                 ....LCSTMEKSVLGGQDQLRVRVTELEDEVRNLRKINRDLFDFSTRFITRP..
Q28IR7_XENTR/381-428                 ....LGESEGKNLSGLVEQLRSRTSELEEELNVVRKINKDLFDFSARIITKQ..
H2L319_ORYLA/353-400                 ....MTAVTDRSVCGDGESTKVHVAELKEEVQILKKVNRELYEFSSQLLTKP..
A0A099Z969_TINGU/278-318             ....MHSTREKNLMGDQEHLTLQVSELEEEVSTLRKINKNLFDFS-------..
F6VKZ1_MONDO/383-430                 ....MCTTLDKNSLGDQEQLKIRVTELEEEVNTLRKINKDLFDFSSHIITK-l.
A0A093H921_STRCA/314-354             ....MCSTREKNLMGDQEHLTIQVSELEEEVSTLRKINKNLFDFS-------..
A0A093QDU0_9PASS/313-353             ..my--LTREKNLVGDQEHLTIQVSELEEEVSNLRKINKDLFNFS-------..
H0X9K9_OTOGA/383-430                 ....MCTTMEKNVLGGQDQLRVRVTELEDEVRNLRKINRDLFDFSTRIITRP..
A0A091FP11_9AVES/314-354             ....MYSTREKNLVGDQEHLTIQVSELEEEVSTLRKINKNLFDFS-------..
A0A0A0MQU0_HUMAN/380-427             ....LCSTMEKSVLGGQDQLRVRVTELEDEVRNLRKINRDLFDFSTRFITRP..
A0A087XUS3_POEFO/414-461             ....MHAVSDKALCGDGENSALRVAELEEEVQTLKKVNKDLFEFSSQLLTKP..
F1LR39_RAT/383-429                   ....LSGYLEKNMLGSQ-MLPVRVFELEEEVRSLRKINRDLFDFSTRIITRP..
H2NWS2_PONAB/367-414                 ....LCSTMEKSVLGGQDQLRVRVTELEDEVRNLRKINRDLFDFSTRFITRP..
I3JA47_ORENI/382-429                 ....MNAMTDKSVFGDGENTKVRIAELEEEVQTLKKMNKDLYDFSSQLLTKP..
H0YQW8_TAEGU/315-355                 ....MYSTREKNLVGDQEHLTIQVSELEEEVSNLRKINKDLFDFS-------..
S9XPC9_CAMFR/455-488                 wrrw------------------DVTELEDEVRNLRKINRDLFDFSTRIITRP..
WDR18_DANRE/383-430                  ....MCAVTDKSVFGDGENTKVRVSELEEEVRTLKKINKDLYEFSTQLLTKP..
M7B7B0_CHEMY/288-335                 ....MCSTREKNLMGDQEQLKIQVTELEDEVSTLRKINKNLFDFSARIITK-s.
W5M196_LEPOC/385-432                 ....MCAITDKRVFGDGENTKVRVAELEEEVKTLKKINKDLYEFSSQLLTKP..
A0A0A0ASL4_CHAVO/314-354             ....MYSTREKNLVGDQEHLTIQVSELEEEVSTLRKINKNLFDFS-------..
V8NEB4_OPHHA/264-311                 ....MCSTREKNLMGNQEQLKIQVTELEEEVNTLRKINKSLFDFSSSIIT--sa
F6QFH9_MACMU/383-430                 ....LCSTMEKSVLGGQDQLRVRVTELEDEVRNLRKINRDLFDFSTRFITRP..
G3VIY2_SARHA/383-430                 ....MCTTLDKNSLGDQEQLKIRVTELEEEVNALRKINKDLFDFSSHIITKP..
A0A091VEE8_NIPNI/314-354             ....MYSTREKNLVGDQEHLTIQVSELEEEVSTLRKINKNLFDFS-------..
I3MXU1_ICTTR/383-430                 ....MCSTMEKNVLGGQDQLRVRVTELEDQVRNLRKINRDLFDFSTRIITRP..
H2QET7_PANTR/335-382                 ....LCSTMEKSVLGGQDQLRVRVTELEDEVRNLRKINRDLFDFSTRFITRP..
G1PIU9_MYOLU/313-360                 ....MCSTMEKNVLGGQDQLRIRITELEDEVQNLRKINRDLFDFSTRIITRP..
#=GC seq_cons                        ....MsSThEKsllGsQ-pL+lRVoELE-EVpsLRKIN+DLFDFSo+lIT+P..
//
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