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Database: Pfam
Entry: 2C_adapt
LinkDB: 2C_adapt
Original site: 2C_adapt 
#=GF ID   2C_adapt
#=GF AC   PF08793.8
#=GF DE   2-cysteine adaptor domain
#=GF AU   Iyer L
#=GF SE   Iyer L
#=GF GA   20.10 20.10;
#=GF TC   20.90 20.50;
#=GF NC   20.00 18.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   16494962
#=GF RT   Evolutionary genomics of nucleo-cytoplasmic large DNA viruses. 
#=GF RA   Iyer LM, Balaji S, Koonin EV, Aravind L; 
#=GF RL   Virus Res. 2006;117:156-184.
#=GF DR   INTERPRO; IPR014901;
#=GF CC   The virus-specific 2-cysteine adaptor domain is found fused to
#=GF CC   OTU/A20-like peptidases and S/T protein kinases.  The domain
#=GF CC   associations of these proteins indicate that they might function
#=GF CC   as viral adaptors connecting the kinases and OTU/A20 peptidases
#=GF CC   to specific targets [1].
#=GF SQ   23
#=GS VF380_IIV3/8-47       AC Q197F0.1
#=GS 019R_FRG3G/5-39       AC Q6GZV6.1
#=GS Q0E553_SFAVA/184-218  AC Q0E553.1
#=GS B3SDT9_TRIAD/36-63    AC B3SDT9.1
#=GS 019R_FRG3G/138-172    AC Q6GZV6.1
#=GS Q0E553_SFAVA/60-94    AC Q0E553.1
#=GS E3T4L7_CROVB/15-44    AC E3T4L7.1
#=GS Q8QUQ5_ISKNN/164-198  AC Q8QUQ5.1
#=GS O41158_PBCV1/63-97    AC O41158.2
#=GS Q0E553_SFAVA/14-48    AC Q0E553.1
#=GS Q8QUQ6_ISKNN/37-75    AC Q8QUQ6.1
#=GS Q8QUQ5_ISKNN/45-79    AC Q8QUQ5.1
#=GS VF378_IIV6/4-38       AC Q91FE6.1
#=GS VF232_IIV6/64-98      AC Q91FU0.1
#=GS VF380_IIV6/7-45       AC Q91FE4.1
#=GS Q8QUQ5_ISKNN/123-157  AC Q8QUQ5.1
#=GS A9WB50_CHLAA/135-157  AC A9WB50.1
#=GS Q0E553_SFAVA/142-176  AC Q0E553.1
#=GS D2XB15_GBMV/3-27      AC D2XB15.1
#=GS Q8QUQ5_ISKNN/7-42     AC Q8QUQ5.1
#=GS 019R_FRG3G/249-283    AC Q6GZV6.1
#=GS 019R_FRG3G/302-336    AC Q6GZV6.1
#=GS 019R_FRG3G/68-102     AC Q6GZV6.1
VF380_IIV3/8-47                  ......KCYEWDIakkkSPlPKSPLTGRKLKQHGPTWKKITAECAT...
019R_FRG3G/5-39                  ......YCDEFER....NP.TRNPRTGRTIKRGGPVFRALERECS-d..
Q0E553_SFAVA/184-218             ......KCIAFDK....ND.KINPFTGRPINENNDTYRMIYSMCHG...
B3SDT9_TRIAD/36-63               lkegye-------....--.-INPTTGRQIKINGPTYRKIH-----nk.
019R_FRG3G/138-172               .....p-CPEFAR....DP.TRNPRTGRTIKRGGPTYRALEAECA-d..
Q0E553_SFAVA/60-94               ......VCKKFLA....NK.TVSPYSGRPIKPGKKLYNDLEKHCSG...
E3T4L7_CROVB/15-44               .....q---KWHY....NK.TVNPRTNRPIKVNGKIYQYLN-----kq.
Q8QUQ5_ISKNN/164-198             ......QCRAFEE....NP.DVNPNTGRRISPTGPIASSMRRRCM-n..
O41158_PBCV1/63-97               .....l-CSKWKA....NP.LVNPATGRKIKKDGPVYEKIQKKCS-v..
Q0E553_SFAVA/14-48               ......QCETFKR....NKqAVSPLTNCPIDKFGRTAARFRKECD-...
Q8QUQ6_ISKNN/37-75               ......VCNDLALcsqhTD.TYNPWTDRALLPDSPVHDMIDYVCNT...
Q8QUQ5_ISKNN/45-79               .....l-CAEYKR....SP.RYNPWTDRTLAPGSPKHNLISGMCGG...
VF378_IIV6/4-38                  ......KCSKWHE....QP.LINPLTNRKIKKNGPTYKELERECG-p..
VF232_IIV6/64-98                 .....e-CEQWLA....NK.GINPRTGKAIKIGGPTYKKLEMECK-e..
VF380_IIV6/7-45                  ......KCDEWEKirlnSS.PKNPFTKRNVKKDGPTYKKIDLICKH...
Q8QUQ5_ISKNN/123-157             .....a-CALYYD....DP.TVNPFTDEPLRRYSPIDDLLYRNCE-s..
A9WB50_CHLAA/135-157             ......-----ER....DQ.RVNPYTGRTISKSDPLA---------hl.
Q0E553_SFAVA/142-176             ......YCTNFHR....DE.SRNPLTGKKLVPTSPIRKAWHKMCSG...
D2XB15_GBMV/3-27                 ...qks-------....--.LVNPKTGRKILRGGPTHLA-------lle
Q8QUQ5_ISKNN/7-42                ......KCNQLRN....NRyTVNPVSNRAIAPRGDTANTLRRICEQ...
019R_FRG3G/249-283               ......VCERFAA....DP.TRNPVTGSPLSRNDPLYTDLMEICKG...
019R_FRG3G/302-336               ......TCEAFCR....DP.TRNPVTGQKMRRNGIEYQMFAEECDC...
019R_FRG3G/68-102                .....p-CPEFAR....DP.TRNPRTGRPIKRGGPVFRALERECA-d..
#=GC seq_cons                    .......Ctpapp....ss.shNPhTGRsIcpsGPsaptlpt.Ct....
//
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