GenomeNet

Database: Pfam
Entry: 4HB_MCP_1
LinkDB: 4HB_MCP_1
Original site: 4HB_MCP_1 
#=GF ID   4HB_MCP_1
#=GF AC   PF12729.6
#=GF DE   Four helix bundle sensory module for signal transduction
#=GF PI   4HB_MCP_2;
#=GF AU   Coggill P
#=GF SE   Ulrich L
#=GF GA   27.00 27.00;
#=GF TC   27.00 27.00;
#=GF NC   26.90 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   16306392
#=GF RT   Four-helix bundle: a ubiquitous sensory module in prokaryotic
#=GF RT   signal transduction.
#=GF RA   Ulrich LE, Zhulin IB;
#=GF RL   Bioinformatics. 2005;21:iii45-iii48.
#=GF DR   INTERPRO; IPR024478;
#=GF CC   This family is a four helix bundle that operates as a ubiquitous
#=GF CC   sensory module in prokaryotic signal-transduction. The 4HB_MCP
#=GF CC   is always found between two predicted transmembrane helices
#=GF CC   indicating that it detects only extracellular signals. In many
#=GF CC   cases the domain is associated with a cytoplasmic HAMP domain
#=GF CC   suggesting that most proteins carrying the bundle might share
#=GF CC   the mechanism of transmembrane signalling which is
#=GF CC   well-characterised in E coli chemoreceptors.
#=GF SQ   4623
#=GS H8FXI3_PHAMO/5-114        AC H8FXI3.1
#=GS L1LVZ0_PSEPU/5-185        AC L1LVZ0.1
#=GS A0A1A6C478_9GAMM/4-169    AC A0A1A6C478.1
#=GS A0A0M2WKX5_9BURK/1-183    AC A0A0M2WKX5.1
#=GS G7LYS5_9CLOT/6-185        AC G7LYS5.1
#=GS A0A014P547_9BURK/5-183    AC A0A014P547.1
#=GS W0HCF9_PSECI/5-184        AC W0HCF9.1
#=GS J3HQG0_9BURK/5-185        AC J3HQG0.1
#=GS A0A0U2LRI2_9BURK/8-190    AC A0A0U2LRI2.1
#=GS Q74DL6_GEOSL/5-184        AC Q74DL6.1
#=GS A0A0B2AVT7_9ACTN/5-190    AC A0A0B2AVT7.1
#=GS S6J7H6_9PSED/5-184        AC S6J7H6.1
#=GS E1TK57_BURSG/3-188        AC E1TK57.1
#=GS M8DGV4_9BACL/2-179        AC M8DGV4.1
#=GS A0A167BA61_9BACL/6-189    AC A0A167BA61.1
#=GS A0A0A8XA92_9BACI/20-192   AC A0A0A8XA92.1
#=GS R7I0S0_9CLOT/9-189        AC R7I0S0.1
#=GS C5T9Z2_ACIDE/9-195        AC C5T9Z2.1
#=GS F3KQ61_9BURK/15-194       AC F3KQ61.1
#=GS A0A0K1IZX8_9RHOO/11-190   AC A0A0K1IZX8.1
#=GS A0A0M2PTK3_PROHO/4-218    AC A0A0M2PTK3.1
#=GS A0A0F5R4U9_9BACL/4-164    AC A0A0F5R4U9.1
#=GS Q3IVW6_RHOS4/1-182        AC Q3IVW6.1
#=GS A0A0A1I3A8_9PSED/1-112    AC A0A0A1I3A8.1
#=GS A0A117V354_9SPHN/10-183   AC A0A117V354.1
#=GS A0A0X8GKP4_9BURK/1-179    AC A0A0X8GKP4.1
#=GS J2M3I9_9BURK/6-186        AC J2M3I9.1
#=GS A0A0D5NG43_9BACL/1-185    AC A0A0D5NG43.1
#=GS H2CDL6_9LEPT/6-188        AC H2CDL6.1
#=GS A5MZG7_CLOK5/6-185        AC A5MZG7.1
#=GS U5MVR9_CLOSA/6-185        AC U5MVR9.1
#=GS F4QJS4_9CAUL/6-184        AC F4QJS4.1
#=GS E3BMH4_9VIBR/2-169        AC E3BMH4.1
#=GS A0A0S2EUP4_9RHIZ/2-167    AC A0A0S2EUP4.1
#=GS D4GEX3_PANAM/31-211       AC D4GEX3.1
#=GS A0A0F6A686_9GAMM/4-184    AC A0A0F6A686.1
#=GS D0IVL9_COMT2/18-196       AC D0IVL9.1
#=GS A0A0B0ENJ8_9BACT/2-163    AC A0A0B0ENJ8.1
#=GS A0A0X8GKG3_9BURK/1-179    AC A0A0X8GKG3.1
#=GS A0A0A1AXN4_9GAMM/1-183    AC A0A0A1AXN4.1
#=GS I4MYC9_9PSED/1-173        AC I4MYC9.1
#=GS A6W6Q1_KINRD/6-184        AC A6W6Q1.1
#=GS Q6DAS0_PECAS/5-185        AC Q6DAS0.1
#=GS I0HVG3_RUBGI/6-185        AC I0HVG3.1
#=GS A0A0Q6ZAL8_9BRAD/4-182    AC A0A0Q6ZAL8.1
#=GS A0A085EX90_9BRAD/3-186    AC A0A085EX90.1
#=GS A5MYV5_CLOK5/6-185        AC A5MYV5.1
#=GS A0A084II18_9GAMM/11-192   AC A0A084II18.1
#=GS Q4KEP4_PSEF5/11-185       AC Q4KEP4.1
#=GS F2LJI4_BURGS/5-190        AC F2LJI4.1
#=GS Q880Z9_PSESM/4-184        AC Q880Z9.1
#=GS G7LXA5_9CLOT/6-184        AC G7LXA5.1
#=GS A0A0F4NYE6_PSEO7/5-184    AC A0A0F4NYE6.1
#=GS A0A0W8JGV9_9VIBR/5-191    AC A0A0W8JGV9.1
#=GS A0A0D5V8V7_9BURK/5-190    AC A0A0D5V8V7.1
#=GS G3J1Q6_9GAMM/5-167        AC G3J1Q6.1
#=GS A0A142XUG6_9PLAN/11-193   AC A0A142XUG6.1
#=GS A4G410_HERAR/5-185        AC A4G410.1
#=GS C8WQK1_ALIAD/28-204       AC C8WQK1.1
#=GS J2WC56_9BURK/6-186        AC J2WC56.1
#=GS C5APG4_METEA/6-185        AC C5APG4.1
#=GS H0Q3K8_9RHOO/1-134        AC H0Q3K8.1
#=GS S9PR13_9DELT/6-196        AC S9PR13.1
#=GS V4NIN5_9CAUL/4-181        AC V4NIN5.1
#=GS D7CM79_SYNLT/14-190       AC D7CM79.1
#=GS A0A085DT45_9GAMM/6-81     AC A0A085DT45.1
#=GS A0A0M8Q5F7_9BACI/1-176    AC A0A0M8Q5F7.1
#=GS I0H5X5_ACTM4/11-191       AC I0H5X5.1
#=GS A0A0S9MWC7_9BURK/6-188    AC A0A0S9MWC7.1
#=GS N2IY32_9PSED/5-185        AC N2IY32.1
#=GS A9WAI3_CHLAA/2-182        AC A9WAI3.1
#=GS A5N138_CLOK5/6-185        AC A5N138.1
#=GS W4CQT8_9BACL/6-186        AC W4CQT8.1
#=GS A6LZX7_CLOB8/6-186        AC A6LZX7.1
#=GS A0A161MFF8_9ACTN/26-155   AC A0A161MFF8.1
#=GS G7ZA44_AZOL4/162-355      AC G7ZA44.1
#=GS A0A0Q6WRM0_9BURK/9-191    AC A0A0Q6WRM0.1
#=GS A0A099S4N1_9CLOT/2-182    AC A0A099S4N1.1
#=GS D2UAE1_XANAP/7-186        AC D2UAE1.1
#=GS A7GM26_BACCN/6-187        AC A7GM26.1
#=GS A0A021X5J0_9RHIZ/2-182    AC A0A021X5J0.1
#=GS A0A0E3WIA7_9BACL/6-186    AC A0A0E3WIA7.1
#=GS D5RJ57_9PROT/6-185        AC D5RJ57.1
#=GS A0A0B2AZV9_9ACTN/5-181    AC A0A0B2AZV9.1
#=GS H5WTI1_9BURK/5-185        AC H5WTI1.1
#=GS A5N786_CLOK5/6-186        AC A5N786.1
#=GS A0A0N0XKV6_9NEIS/6-185    AC A0A0N0XKV6.1
#=GS R6ZE96_9FIRM/13-190       AC R6ZE96.1
#=GS G8ME00_9BURK/3-188        AC G8ME00.1
#=GS B2JTC0_PARP8/1-167        AC B2JTC0.1
#=GS A4J567_DESRM/66-229       AC A4J567.1
#=GS I4DB94_DESAJ/6-191        AC I4DB94.1
#=GS A0A078LUU5_9PSED/4-184    AC A0A078LUU5.1
#=GS Q24U91_DESHY/6-186        AC Q24U91.1
#=GS A0A0S2EMM4_9RHIZ/1-162    AC A0A0S2EMM4.1
#=GS I4N2R3_9PSED/5-185        AC I4N2R3.1
#=GS A0A0J8VI81_9GAMM/5-184    AC A0A0J8VI81.1
#=GS U5BR79_9BACT/1-159        AC U5BR79.1
#=GS Q7NV37_CHRVO/6-185        AC Q7NV37.1
#=GS A0A0X8GRD2_9BURK/1-174    AC A0A0X8GRD2.1
#=GS F3KRP2_9BURK/3-183        AC F3KRP2.1
#=GS B2FUD5_STRMK/6-183        AC B2FUD5.1
#=GS A0A120D309_9BACT/4-185    AC A0A120D309.1
#=GS W8QYR1_PSEST/3-183        AC W8QYR1.1
#=GS R4LPQ5_9ACTN/10-194       AC R4LPQ5.1
#=GS Q2FQT7_METHJ/9-189        AC Q2FQT7.1
#=GS A0A0A5HUC1_9VIBR/5-191    AC A0A0A5HUC1.1
#=GS R9JZJ1_9FIRM/7-186        AC R9JZJ1.1
#=GS R5I3I8_9FIRM/17-188       AC R5I3I8.1
#=GS A0A0X8D4E8_9BACL/1-176    AC A0A0X8D4E8.1
#=GS A9C2Q0_DELAS/6-188        AC A9C2Q0.1
#=GS V5UJX2_9BURK/5-185        AC V5UJX2.1
#=GS F3KPN1_9BURK/6-191        AC F3KPN1.1
#=GS A0A0R0MJT8_9BURK/11-192   AC A0A0R0MJT8.1
#=GS A0A089N9T1_9BACL/1-179    AC A0A089N9T1.1
#=GS N6Y6A8_9RHOO/1-173        AC N6Y6A8.1
#=GS K9E0V4_9BURK/5-190        AC K9E0V4.1
#=GS A0A0F5IDT5_9BACI/1-179    AC A0A0F5IDT5.1
#=GS A0A0Q6XUW4_9BURK/12-192   AC A0A0Q6XUW4.1
#=GS A0A094JEX8_9GAMM/2-184    AC A0A094JEX8.1
#=GS C0C1R0_9FIRM/8-191        AC C0C1R0.1
#=GS A0A142XME1_9PLAN/6-201    AC A0A142XME1.1
#=GS W7YTI3_9BACL/1-173        AC W7YTI3.1
#=GS A9AWM6_HERA2/9-188        AC A9AWM6.1
#=GS S2KE91_9GAMM/1-181        AC S2KE91.1
#=GS Q5GYX0_XANOR/7-186        AC Q5GYX0.1
#=GS M3FE53_LEPBO/1-179        AC M3FE53.1
#=GS J2UQZ4_9BURK/6-186        AC J2UQZ4.1
#=GS A9BPB9_DELAS/9-190        AC A9BPB9.1
#=GS C4L6Z2_EXISA/4-178        AC C4L6Z2.1
#=GS V2G682_9BURK/1-166        AC V2G682.1
#=GS A2SGG8_METPP/28-207       AC A2SGG8.1
#=GS A0A0Q6VR41_9BURK/24-204   AC A0A0Q6VR41.1
#=GS A0A133XEG0_9RHOO/1-179    AC A0A133XEG0.1
#=GS R6LVL9_9CLOT/3-186        AC R6LVL9.1
#=GS I9LIR3_9FIRM/2-171        AC I9LIR3.1
#=GS A0A0D2VM77_9PROT/6-184    AC A0A0D2VM77.1
#=GS G2DVQ0_9GAMM/4-184        AC G2DVQ0.1
#=GS F2AHP6_RHIET/2-181        AC F2AHP6.1
#=GS A0A0E4CZ73_9BACL/1-179    AC A0A0E4CZ73.1
#=GS M4NGJ3_9GAMM/12-187       AC M4NGJ3.1
#=GS W3AQ60_9FIRM/6-183        AC W3AQ60.1
#=GS S6J3R7_9PSED/5-185        AC S6J3R7.1
#=GS A0A0J1GEM5_9BURK/1-183    AC A0A0J1GEM5.1
#=GS I6YXC8_MELRP/7-205        AC I6YXC8.1
#=GS A6M0D3_CLOB8/2-182        AC A6M0D3.1
#=GS G2DY41_9GAMM/2-180        AC G2DY41.1
#=GS J0KDQ3_9BURK/5-190        AC J0KDQ3.1
#=GS A0A0P7XMH1_9GAMM/1-175    AC A0A0P7XMH1.1
#=GS R5WCB6_9CLOT/10-193       AC R5WCB6.1
#=GS A0A0Q5NVU5_9BURK/5-188    AC A0A0Q5NVU5.1
#=GS U5MUN0_CLOSA/1-182        AC U5MUN0.1
#=GS U5W9K7_9ACTN/23-196       AC U5W9K7.1
#=GS A0A098SXN2_9PSED/5-185    AC A0A098SXN2.1
#=GS Q9HXT3_PSEAE/3-186        AC Q9HXT3.1
#=GS R9JLR8_9FIRM/4-183        AC R9JLR8.1
#=GS E8RQH6_ASTEC/4-182        AC E8RQH6.1
#=GS U2ED36_9FIRM/2-176        AC U2ED36.1
#=GS K6TU79_9CLOT/4-184        AC K6TU79.1
#=GS C3K4R7_PSEFS/5-185        AC C3K4R7.1
#=GS A0A176J5X7_9BACI/1-181    AC A0A176J5X7.1
#=GS A0A0U3LP78_9BURK/5-189    AC A0A0U3LP78.1
#=GS Q1LH21_CUPMC/6-191        AC Q1LH21.1
#=GS A0A0A6SRN4_9BURK/10-187   AC A0A0A6SRN4.1
#=GS Q2IQS1_ANADE/6-186        AC Q2IQS1.1
#=GS A0A117V3R3_9SPHN/3-177    AC A0A117V3R3.1
#=GS A0A0Q9XXW8_9BACI/5-173    AC A0A0Q9XXW8.1
#=GS A0A0A8WE66_CLOSO/3-173    AC A0A0A8WE66.1
#=GS N9VDC0_9GAMM/4-189        AC N9VDC0.1
#=GS H3SGJ3_9BACL/1-182        AC H3SGJ3.1
#=GS W8QYJ6_PSEST/6-188        AC W8QYJ6.1
#=GS A0A0Q8B0A2_9RHIZ/5-183    AC A0A0Q8B0A2.1
#=GS A0A085F8K3_9BURK/4-185    AC A0A085F8K3.1
#=GS A0A090VJV1_9FLAO/1-165    AC A0A090VJV1.1
#=GS D6Z1A7_DESAT/4-141        AC D6Z1A7.1
#=GS A0A0A6SX93_9BURK/20-199   AC A0A0A6SX93.1
#=GS R7QXJ5_9FIRM/2-183        AC R7QXJ5.1
#=GS A0A0A3J2Q3_9BACI/6-113    AC A0A0A3J2Q3.1
#=GS A0A098EU30_9BACI/6-183    AC A0A098EU30.1
#=GS A0A085EV05_9BURK/5-190    AC A0A085EV05.1
#=GS R9JDK0_9FIRM/7-187        AC R9JDK0.1
#=GS W8X0B5_CASDE/3-181        AC W8X0B5.1
#=GS A0A0Q6XQB2_9BURK/5-185    AC A0A0Q6XQB2.1
#=GS A0A0N8NSS7_9CLOT/4-185    AC A0A0N8NSS7.1
#=GS D8IXA5_HERSS/4-189        AC D8IXA5.1
#=GS A0A0G3A2B4_9DELT/6-186    AC A0A0G3A2B4.1
#=GS B4EMK9_BURCJ/5-185        AC B4EMK9.1
#=GS L0G2F2_ECHVK/5-180        AC L0G2F2.1
#=GS K2JZ05_9GAMM/5-184        AC K2JZ05.1
#=GS A0A136HSU8_9GAMM/7-190    AC A0A136HSU8.1
#=GS A0A0H1RD30_9RHIZ/5-184    AC A0A0H1RD30.1
#=GS A0A0A6UCJ9_ACTUT/20-199   AC A0A0A6UCJ9.1
#=GS A0A136Q5G6_9FIRM/10-188   AC A0A136Q5G6.1
#=GS A0A0Q7XLY8_9RHIZ/2-181    AC A0A0Q7XLY8.1
#=GS R6LSE7_9CLOT/11-193       AC R6LSE7.1
#=GS F0SUK7_SYNGF/3-185        AC F0SUK7.1
#=GS A0A084JAR2_9CLOT/6-187    AC A0A084JAR2.1
#=GS N2A5A5_9CLOT/3-180        AC N2A5A5.1
#=GS Q8F2F8_LEPIN/1-172        AC Q8F2F8.2
#=GS K0HXJ5_9BURK/3-182        AC K0HXJ5.1
#=GS A0A0F4QL46_9GAMM/6-189    AC A0A0F4QL46.1
#=GS A0A071LRA1_9ENTR/3-183    AC A0A071LRA1.1
#=GS J0KRD3_9BURK/3-183        AC J0KRD3.1
#=GS A0A1A6C3S6_9GAMM/5-171    AC A0A1A6C3S6.1
#=GS A1WBZ5_ACISJ/6-188        AC A1WBZ5.1
#=GS A0A0B2JNG9_9FIRM/6-187    AC A0A0B2JNG9.1
#=GS A0A0Q4XNF5_9RHIZ/4-184    AC A0A0Q4XNF5.1
#=GS A0A0Q4G6C4_9BURK/5-183    AC A0A0Q4G6C4.1
#=GS A0A0Q6EVS4_9RHIZ/2-168    AC A0A0Q6EVS4.1
#=GS F2JWA6_MARM1/2-177        AC F2JWA6.1
#=GS A0A089N1Q3_9BACL/3-184    AC A0A089N1Q3.1
#=GS T2G831_DESGI/3-172        AC T2G831.1
#=GS Q3IXN5_RHOS4/7-186        AC Q3IXN5.1
#=GS A0A0C9N2Z6_SPHPI/7-186    AC A0A0C9N2Z6.1
#=GS U3U6F9_9ENTR/1-172        AC U3U6F9.1
#=GS S0JFT8_9FIRM/3-179        AC S0JFT8.1
#=GS A0A0J1D7S4_9BURK/5-185    AC A0A0J1D7S4.1
#=GS A0A0Q6W349_9BURK/6-186    AC A0A0Q6W349.1
#=GS A5I5R4_CLOBH/4-185        AC A5I5R4.1
#=GS A0A0N0E504_9PSED/5-185    AC A0A0N0E504.1
#=GS J6IXH4_9RHOB/6-181        AC J6IXH4.1
#=GS T0I8E4_9SPHN/7-185        AC T0I8E4.1
#=GS A0A0B5AKJ9_9BACL/1-173    AC A0A0B5AKJ9.1
#=GS D0J5C0_COMT2/3-183        AC D0J5C0.1
#=GS G4KYB6_OSCVS/10-191       AC G4KYB6.1
#=GS V5ANN0_ENTCL/1-183        AC V5ANN0.1
#=GS W0H6U8_PSECI/5-190        AC W0H6U8.1
#=GS W0ECT8_9FIRM/6-189        AC W0ECT8.1
#=GS A0A0C2BVR4_9BURK/5-185    AC A0A0C2BVR4.1
#=GS A0A0Q5H5M9_9BURK/4-185    AC A0A0Q5H5M9.1
#=GS A0A0Q9SEW4_9BACL/15-191   AC A0A0Q9SEW4.1
#=GS A0A071LTL4_9ENTR/6-180    AC A0A071LTL4.1
#=GS R6KCS7_9FIRM/14-187       AC R6KCS7.1
#=GS M8DK48_9BACL/6-185        AC M8DK48.1
#=GS N6UPJ1_9RHIZ/6-189        AC N6UPJ1.1
#=GS D9SVT3_CLOC7/6-191        AC D9SVT3.1
#=GS A0A0F6AEV5_9GAMM/1-127    AC A0A0F6AEV5.1
#=GS A0A0Q6VNR7_9BURK/5-189    AC A0A0Q6VNR7.1
#=GS S6JHG4_9PSED/5-185        AC S6JHG4.1
#=GS A0A0A3JZM0_9BACI/1-176    AC A0A0A3JZM0.1
#=GS A0A0S8DH73_9BACT/25-206   AC A0A0S8DH73.1
#=GS A0A0B8WT45_9DELT/11-196   AC A0A0B8WT45.1
#=GS I0XPV9_9LEPT/6-185        AC I0XPV9.1
#=GS W0V029_9BURK/1-178        AC W0V029.1
#=GS G2FNX7_9FIRM/1-180        AC G2FNX7.1
#=GS D9R575_CLOSW/8-188        AC D9R575.1
#=GS I4EQU0_9ACTN/19-203       AC I4EQU0.1
#=GS L8JE02_9GAMM/1-177        AC L8JE02.1
#=GS Q98PC6_RHILO/3-187        AC Q98PC6.1
#=GS K2K8J8_9GAMM/5-184        AC K2K8J8.1
#=GS B1C883_9FIRM/9-182        AC B1C883.1
#=GS W0SFT6_9RHOO/10-191       AC W0SFT6.1
#=GS A0A0A2W5R0_BEABA/5-185    AC A0A0A2W5R0.1
#=GS S0G693_9DELT/2-179        AC S0G693.1
#=GS A0A0M2K742_9GAMM/1-183    AC A0A0M2K742.1
#=GS U5RZ70_9CLOT/6-185        AC U5RZ70.1
#=GS F0LXP6_VIBFN/5-180        AC F0LXP6.1
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S6GL88_9GAMM/2-182                   ..................................fks--.-LRAKLA..TS..FG.V.I..FFI....L.V.LA....T.......GSN.L...Y.YV...N..Q...VN..E..V..Q..D...R..V..I..K...L...R...F....E....T..V.K.A.G..KD.I.N....N....G....I....N....S....S..L...A.A...L...R...G.............Y.....M......I.....L....gG...........D....P...AK..............GA...E.....M....K.......K...Q...R.......A...A....A.......W.....L.....L.......I....E......K..S..........I....A....T.....F......N.......A.......V......S........V..........Nw.......tvP.......K.....N.....L.Q...TF..A...K..L...K...K...V...L....V...E..F....KE....A.....Q....Q.......L.....V....E..E...V......A.....Q....H.....K.S...N.I....................AS...Y...Q....V....L...L......V.E......A.A........PRA...A.K...I...L...S...T.L...T.G..I.I.D...L.E.E....Q...Q.------------yaskgrka.................................................................................
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