GenomeNet

Database: Pfam
Entry: 4HB_MCP_1
LinkDB: 4HB_MCP_1
Original site: 4HB_MCP_1 
#=GF ID   4HB_MCP_1
#=GF AC   PF12729.5
#=GF DE   Four helix bundle sensory module for signal transduction
#=GF PI   4HB_MCP_2;
#=GF AU   Coggill P
#=GF SE   Ulrich L
#=GF GA   27.00 27.00;
#=GF TC   27.00 27.00;
#=GF NC   26.90 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   16306392
#=GF RT   Four-helix bundle: a ubiquitous sensory module in prokaryotic
#=GF RT   signal transduction.
#=GF RA   Ulrich LE, Zhulin IB;
#=GF RL   Bioinformatics. 2005;21:iii45-iii48.
#=GF DR   INTERPRO; IPR024478;
#=GF CC   This family is a four helix bundle that operates as a ubiquitous
#=GF CC   sensory module in prokaryotic signal-transduction. The 4HB_MCP
#=GF CC   is always found between two predicted transmembrane helices
#=GF CC   indicating that it detects only extracellular signals. In many
#=GF CC   cases the domain is associated with a cytoplasmic HAMP domain
#=GF CC   suggesting that most proteins carrying the bundle might share
#=GF CC   the mechanism of transmembrane signalling which is
#=GF CC   well-characterised in E coli chemoreceptors.
#=GF SQ   2887
#=GS A6Q3G7_NITSB/9-196        AC A6Q3G7.1
#=GS H8FXI3_PHAMO/5-114        AC H8FXI3.1
#=GS A0RQA2_CAMFF/7-142        AC A0RQA2.1
#=GS I0HM96_RUBGI/4-182        AC I0HM96.1
#=GS T2L388_9GAMM/163-340      AC T2L388.1
#=GS A0A0M2WKX5_9BURK/1-183    AC A0A0M2WKX5.1
#=GS D7DHR3_METV0/1-189        AC D7DHR3.1
#=GS G7LYS5_9CLOT/6-185        AC G7LYS5.1
#=GS J3D6V0_9BURK/6-183        AC J3D6V0.1
#=GS W0HCF9_PSECI/5-184        AC W0HCF9.1
#=GS K6YAN7_9ALTE/5-188        AC K6YAN7.1
#=GS J3HQG0_9BURK/5-185        AC J3HQG0.1
#=GS I0HQ13_RUBGI/6-186        AC I0HQ13.1
#=GS Q74DL6_GEOSL/5-184        AC Q74DL6.1
#=GS A0A0B4X7U8_9RHIZ/3-183    AC A0A0B4X7U8.1
#=GS Q13RH8_BURXL/6-172        AC Q13RH8.1
#=GS E1TK57_BURSG/3-188        AC E1TK57.1
#=GS Q21SE0_RHOFT/1-183        AC Q21SE0.1
#=GS J2UY26_9BURK/1-180        AC J2UY26.1
#=GS C5CXU2_VARPS/6-192        AC C5CXU2.1
#=GS R7I0S0_9CLOT/9-189        AC R7I0S0.1
#=GS C5T9Z2_ACIDE/9-195        AC C5T9Z2.1
#=GS B2JT21_BURP8/5-188        AC B2JT21.1
#=GS A0A0M3BM85_9RHIZ/1-177    AC A0A0M3BM85.1
#=GS H0TJE9_9BRAD/4-187        AC H0TJE9.1
#=GS A0A0M2PTK3_PROHO/4-218    AC A0A0M2PTK3.1
#=GS Q3IVW6_RHOS4/1-182        AC Q3IVW6.1
#=GS H8FUE0_PHAMO/1-129        AC H8FUE0.1
#=GS M1MR86_9CLOT/6-186        AC M1MR86.1
#=GS A0A077LCA4_9PSED/6-191    AC A0A077LCA4.1
#=GS F2LGU1_BURGS/1-177        AC F2LGU1.1
#=GS J2M3I9_9BURK/6-186        AC J2M3I9.1
#=GS A0A0D8IC08_9CLOT/6-185    AC A0A0D8IC08.1
#=GS G8TMY7_NIAKG/3-186        AC G8TMY7.1
#=GS H2CDL6_9LEPT/6-188        AC H2CDL6.1
#=GS A5MZG7_CLOK5/6-185        AC A5MZG7.1
#=GS A0A0D5NG43_9BACL/1-185    AC A0A0D5NG43.1
#=GS U5MVR9_CLOSA/6-185        AC U5MVR9.1
#=GS F4QJS4_9CAUL/6-184        AC F4QJS4.1
#=GS G2E1P4_9GAMM/6-187        AC G2E1P4.1
#=GS Q9I3B3_PSEAE/5-185        AC Q9I3B3.1
#=GS E3BMH4_9VIBR/2-169        AC E3BMH4.1
#=GS J2UHJ2_9BURK/22-202       AC J2UHJ2.1
#=GS M1MLU7_9CLOT/4-185        AC M1MLU7.1
#=GS H0PT25_9RHOO/4-184        AC H0PT25.1
#=GS W5X1B5_BDEBC/3-170        AC W5X1B5.1
#=GS D6Y0J8_BACIE/1-175        AC D6Y0J8.1
#=GS D4GEX3_PANAM/31-211       AC D4GEX3.1
#=GS C9R9R3_AMMDK/13-187       AC C9R9R3.1
#=GS A0A0F6A686_9GAMM/4-184    AC A0A0F6A686.1
#=GS D0IVL9_COMT2/18-196       AC D0IVL9.1
#=GS Q67QH6_SYMTH/6-181        AC Q67QH6.1
#=GS A0A089UGZ0_9ENTR/6-180    AC A0A089UGZ0.1
#=GS C4IHA5_CLOBU/10-191       AC C4IHA5.1
#=GS A0A0A1AXN4_9ENTR/1-183    AC A0A0A1AXN4.1
#=GS I4MYC9_9PSED/1-173        AC I4MYC9.1
#=GS A6W6Q1_KINRD/6-184        AC A6W6Q1.1
#=GS I0HVG3_RUBGI/6-185        AC I0HVG3.1
#=GS Q6DAS0_PECAS/5-185        AC Q6DAS0.1
#=GS I0HAJ3_ACTM4/46-226       AC I0HAJ3.1
#=GS A5MYV5_CLOK5/6-185        AC A5MYV5.1
#=GS A8ESY2_ARCB4/6-185        AC A8ESY2.1
#=GS Q4KEP4_PSEF5/11-185       AC Q4KEP4.1
#=GS F2LJI4_BURGS/5-190        AC F2LJI4.1
#=GS Q880Z9_PSESM/4-184        AC Q880Z9.1
#=GS A0A068SYV8_RHIGA/2-181    AC A0A068SYV8.1
#=GS R5UPB5_9FIRM/11-191       AC R5UPB5.1
#=GS G7LXA5_9CLOT/6-184        AC G7LXA5.1
#=GS A0A0F4NYE6_PSEO7/5-184    AC A0A0F4NYE6.1
#=GS A0A023Y3L3_9GAMM/6-186    AC A0A023Y3L3.1
#=GS G8M9W2_9BURK/6-184        AC G8M9W2.1
#=GS T2L1L3_9GAMM/8-186        AC T2L1L3.1
#=GS K1YC09_9BACT/4-184        AC K1YC09.1
#=GS A0A0D5V8V7_9BURK/5-190    AC A0A0D5V8V7.1
#=GS Q4K5M6_PSEF5/5-184        AC Q4K5M6.1
#=GS T2GFT4_DESGI/6-187        AC T2GFT4.1
#=GS G3J1Q6_9GAMM/5-167        AC G3J1Q6.1
#=GS C8WQK1_ALIAD/28-204       AC C8WQK1.1
#=GS A4G410_HERAR/5-185        AC A4G410.1
#=GS J2WC56_9BURK/6-186        AC J2WC56.1
#=GS K0NAK5_DESTT/6-185        AC K0NAK5.1
#=GS C5APG4_METEA/6-185        AC C5APG4.1
#=GS H0Q3K8_9RHOO/1-134        AC H0Q3K8.1
#=GS D7CM79_SYNLT/14-190       AC D7CM79.1
#=GS A6M0R6_CLOB8/4-175        AC A6M0R6.1
#=GS I0H5X5_ACTM4/11-191       AC I0H5X5.1
#=GS I4N9Z8_9PSED/20-201       AC I4N9Z8.1
#=GS G8QCU0_PSEFL/5-185        AC G8QCU0.1
#=GS A0A0N0JT21_9PROT/5-187    AC A0A0N0JT21.1
#=GS R7IS85_9FIRM/7-189        AC R7IS85.1
#=GS A9WAI3_CHLAA/2-182        AC A9WAI3.1
#=GS A5N138_CLOK5/6-185        AC A5N138.1
#=GS B9JZK5_AGRVS/1-164        AC B9JZK5.1
#=GS A6LZX7_CLOB8/6-186        AC A6LZX7.1
#=GS A7C187_9GAMM/6-107        AC A7C187.1
#=GS A0A0A8E2V7_9XANT/7-188    AC A0A0A8E2V7.1
#=GS A0A0C4YM43_9BURK/7-187    AC A0A0C4YM43.1
#=GS G7ZA44_AZOL4/162-355      AC G7ZA44.1
#=GS A8ESH4_ARCB4/4-183        AC A8ESH4.1
#=GS R4KB45_9FIRM/5-185        AC R4KB45.1
#=GS D2UAE1_XANAP/7-186        AC D2UAE1.1
#=GS A7GM26_BACCN/6-187        AC A7GM26.1
#=GS A1TP11_ACIAC/1-184        AC A1TP11.1
#=GS F8A264_CELGA/11-125       AC F8A264.1
#=GS D8J1N7_HERSS/6-186        AC D8J1N7.1
#=GS A0A0E3WIA7_9BACL/6-186    AC A0A0E3WIA7.1
#=GS D5RJ57_9PROT/6-185        AC D5RJ57.1
#=GS A0A090AIL5_9GAMM/4-168    AC A0A090AIL5.1
#=GS H5WTI1_9BURK/5-185        AC H5WTI1.1
#=GS A0A0A1MKM6_9BACI/6-170    AC A0A0A1MKM6.1
#=GS E0SFF6_DICD3/4-187        AC E0SFF6.1
#=GS A5N786_CLOK5/6-186        AC A5N786.1
#=GS J7IUT9_DESMD/1-179        AC J7IUT9.1
#=GS I0GPD6_SELRL/6-188        AC I0GPD6.1
#=GS A0A0N0XKV6_9NEIS/6-185    AC A0A0N0XKV6.1
#=GS R6ZE96_9FIRM/13-190       AC R6ZE96.1
#=GS G8ME00_9BURK/3-188        AC G8ME00.1
#=GS B2JTC0_BURP8/1-167        AC B2JTC0.1
#=GS A4J567_DESRM/66-229       AC A4J567.1
#=GS I4DB94_DESAJ/6-191        AC I4DB94.1
#=GS J1EH35_9BURK/18-197       AC J1EH35.1
#=GS Q24U91_DESHY/6-186        AC Q24U91.1
#=GS I4N2R3_9PSED/5-185        AC I4N2R3.1
#=GS Q8P9I5_XANCP/2-128        AC Q8P9I5.1
#=GS B1M856_METRJ/2-170        AC B1M856.1
#=GS Q7NV37_CHRVO/6-185        AC Q7NV37.1
#=GS A0A0J6RS65_9RHIZ/2-184    AC A0A0J6RS65.1
#=GS Q6LNI4_PHOPR/4-103        AC Q6LNI4.1
#=GS A0A0F6AE99_9GAMM/2-185    AC A0A0F6AE99.1
#=GS B0SLZ4_LEPBP/6-185        AC B0SLZ4.1
#=GS H1G1R6_9GAMM/4-183        AC H1G1R6.1
#=GS B2FUD5_STRMK/6-183        AC B2FUD5.1
#=GS G2DZW7_9GAMM/1-180        AC G2DZW7.1
#=GS W8QYR1_PSEST/3-183        AC W8QYR1.1
#=GS R4LPQ5_9ACTN/10-194       AC R4LPQ5.1
#=GS A0A0A8DTH5_9XANT/4-187    AC A0A0A8DTH5.1
#=GS Q87Z51_PSESM/6-189        AC Q87Z51.1
#=GS J1ES22_9BURK/5-195        AC J1ES22.1
#=GS Q2FQT7_METHJ/9-189        AC Q2FQT7.1
#=GS V6EXM3_9PROT/4-176        AC V6EXM3.1
#=GS K0PDP1_9RHIZ/37-217       AC K0PDP1.1
#=GS R5I3I8_9FIRM/17-188       AC R5I3I8.1
#=GS K0I2U9_9BURK/4-185        AC K0I2U9.1
#=GS V5UJX2_9BURK/5-185        AC V5UJX2.1
#=GS A4JLK0_BURVG/21-199       AC A4JLK0.1
#=GS A9C2Q0_DELAS/6-188        AC A9C2Q0.1
#=GS Q1DFX2_MYXXD/1-172        AC Q1DFX2.1
#=GS J2W3Q0_9BURK/6-186        AC J2W3Q0.1
#=GS A0A089N9T1_9BACL/1-179    AC A0A089N9T1.1
#=GS A0A0F3KAV0_9NEIS/1-180    AC A0A0F3KAV0.1
#=GS A0A0F5IDT5_9BACI/1-179    AC A0A0F5IDT5.1
#=GS A0A0M2WKM2_9BURK/6-186    AC A0A0M2WKM2.1
#=GS C0C1R0_9FIRM/8-191        AC C0C1R0.1
#=GS A8MGQ9_ALKOO/6-183        AC A8MGQ9.1
#=GS A1WA29_ACISJ/19-199       AC A1WA29.1
#=GS YOAH_BACSU/1-174          AC C0SP89.1
#=GS Q8P9J4_XANCP/8-187        AC Q8P9J4.1
#=GS A9AWM6_HERA2/9-188        AC A9AWM6.1
#=GS C7QZM3_JONDD/26-193       AC C7QZM3.1
#=GS Q5GYX0_XANOR/7-186        AC Q5GYX0.1
#=GS C4IBM3_CLOBU/23-199       AC C4IBM3.1
#=GS A0A0F4NG43_9VIBR/6-119    AC A0A0F4NG43.1
#=GS C0QMJ7_DESAH/3-166        AC C0QMJ7.1
#=GS C4XMF9_DESMR/10-193       AC C4XMF9.1
#=GS J2UQZ4_9BURK/6-186        AC J2UQZ4.1
#=GS B8DQK6_DESVM/3-190        AC B8DQK6.1
#=GS A9BPB9_DELAS/9-190        AC A9BPB9.1
#=GS R5F6E2_9CLOT/1-169        AC R5F6E2.1
#=GS C4L6Z2_EXISA/4-178        AC C4L6Z2.1
#=GS M1WLI5_DESPC/13-189       AC M1WLI5.1
#=GS A2SGG8_METPP/28-207       AC A2SGG8.1
#=GS A0A077LCG4_9PSED/2-160    AC A0A077LCG4.1
#=GS R6LVL9_9CLOT/3-186        AC R6LVL9.1
#=GS I9LIR3_9FIRM/2-171        AC I9LIR3.1
#=GS K0NQ88_DESTT/4-153        AC K0NQ88.1
#=GS G2DVQ0_9GAMM/4-184        AC G2DVQ0.1
#=GS Q97FJ1_CLOAB/6-185        AC Q97FJ1.1
#=GS U4K915_9VIBR/12-193       AC U4K915.1
#=GS F2AHP6_RHIET/2-181        AC F2AHP6.1
#=GS A0A0E4CZ73_9BACL/1-179    AC A0A0E4CZ73.1
#=GS M4NGJ3_9GAMM/12-187       AC M4NGJ3.1
#=GS A0A0C4Y9N9_9BURK/6-189    AC A0A0C4Y9N9.1
#=GS Q5E156_VIBF1/5-177        AC Q5E156.1
#=GS E6WMI3_PANSA/1-134        AC E6WMI3.1
#=GS G8TMY8_NIAKG/2-184        AC G8TMY8.1
#=GS I4VNE7_9GAMM/1-150        AC I4VNE7.1
#=GS A0A077FJ55_9PSED/3-182    AC A0A077FJ55.1
#=GS F6CNG5_DESK7/1-122        AC F6CNG5.1
#=GS A6M0D3_CLOB8/2-182        AC A6M0D3.1
#=GS I6YXC8_MELRP/7-205        AC I6YXC8.1
#=GS G2DY41_9GAMM/2-180        AC G2DY41.1
#=GS J0KDQ3_9BURK/5-190        AC J0KDQ3.1
#=GS R5WCB6_9CLOT/10-193       AC R5WCB6.1
#=GS F6AHS9_PSEF1/5-191        AC F6AHS9.1
#=GS U5MUN0_CLOSA/1-182        AC U5MUN0.1
#=GS U5W9K7_9ACTN/23-196       AC U5W9K7.1
#=GS Q9HXT3_PSEAE/3-186        AC Q9HXT3.1
#=GS Q47GY2_DECAR/4-184        AC Q47GY2.1
#=GS J2IZ35_9ENTR/5-183        AC J2IZ35.1
#=GS A0A0K1QQK8_PSEFL/1-182    AC A0A0K1QQK8.1
#=GS E8RQH6_ASTEC/4-182        AC E8RQH6.1
#=GS A1ZFP4_9BACT/1-169        AC A1ZFP4.1
#=GS H6NJK1_9BACL/2-181        AC H6NJK1.1
#=GS J0K5K3_9BURK/4-184        AC J0K5K3.1
#=GS C4L692_EXISA/1-180        AC C4L692.1
#=GS M1MDH3_9CLOT/4-185        AC M1MDH3.1
#=GS Q146P1_BURXL/2-179        AC Q146P1.1
#=GS K6TU79_9CLOT/4-184        AC K6TU79.1
#=GS C3K4R7_PSEFS/5-185        AC C3K4R7.1
#=GS Q250C4_DESHY/23-203       AC Q250C4.1
#=GS Q1LH21_CUPMC/6-191        AC Q1LH21.1
#=GS A9EA75_9FLAO/1-166        AC A9EA75.1
#=GS Q2IQS1_ANADE/6-186        AC Q2IQS1.1
#=GS A0A0A8WE66_CLOSO/3-173    AC A0A0A8WE66.1
#=GS W8QYJ6_PSEST/6-188        AC W8QYJ6.1
#=GS H3SGJ3_9BACL/1-182        AC H3SGJ3.1
#=GS D5WJJ2_BURSC/7-189        AC D5WJJ2.1
#=GS A0A0M2KD44_9ENTR/6-186    AC A0A0M2KD44.1
#=GS D6Z1A7_DESAT/4-141        AC D6Z1A7.1
#=GS R7QXJ5_9FIRM/2-183        AC R7QXJ5.1
#=GS A0A098EU30_9BACI/6-183    AC A0A098EU30.1
#=GS A0A0J6U2X0_9RHIZ/4-181    AC A0A0J6U2X0.1
#=GS J2WC65_9BURK/6-186        AC J2WC65.1
#=GS A0A0M2WIL4_9BURK/6-186    AC A0A0M2WIL4.1
#=GS A0A0M9WVL1_9BACI/2-169    AC A0A0M9WVL1.1
#=GS A0A0F4QUJ1_9GAMM/5-118    AC A0A0F4QUJ1.1
#=GS W8X0B5_CASDE/3-181        AC W8X0B5.1
#=GS D6SSS5_9DELT/3-143        AC D6SSS5.1
#=GS D8IXA5_HERSS/4-189        AC D8IXA5.1
#=GS K6U6X2_9CLOT/11-195       AC K6U6X2.1
#=GS A0A0G3A2B4_9DELT/6-186    AC A0A0G3A2B4.1
#=GS B4EMK9_BURCJ/5-185        AC B4EMK9.1
#=GS D3NU42_AZOS1/6-187        AC D3NU42.1
#=GS L0G2F2_ECHVK/5-180        AC L0G2F2.1
#=GS W0V1R7_9BURK/5-189        AC W0V1R7.1
#=GS A0A0F2PR12_9FIRM/1-179    AC A0A0F2PR12.1
#=GS E1RAC0_SPISS/4-143        AC E1RAC0.1
#=GS Q63J42_BURPS/21-199       AC Q63J42.1
#=GS D5WL45_BURSC/5-182        AC D5WL45.1
#=GS A0A089LU00_9BACL/25-198   AC A0A089LU00.1
#=GS A0A0D5V8H4_9BURK/6-185    AC A0A0D5V8H4.1
#=GS R6LSE7_9CLOT/11-193       AC R6LSE7.1
#=GS F0SUK7_SYNGF/3-185        AC F0SUK7.1
#=GS B8DK88_DESVM/12-189       AC B8DK88.1
#=GS A0A0N0ZCE6_9BURK/5-185    AC A0A0N0ZCE6.1
#=GS C4ZC11_AGARV/14-188       AC C4ZC11.1
#=GS Q8F2F8_LEPIN/1-172        AC Q8F2F8.2
#=GS K0HXJ5_9BURK/3-182        AC K0HXJ5.1
#=GS A0A0F4QL46_9GAMM/6-189    AC A0A0F4QL46.1
#=GS D5RIJ1_9PROT/1-180        AC D5RIJ1.1
#=GS Q2RUV1_RHORT/6-185        AC Q2RUV1.1
#=GS C5ALI2_BURGB/3-189        AC C5ALI2.1
#=GS H0JB67_9PSED/5-187        AC H0JB67.1
#=GS J0KRD3_9BURK/3-183        AC J0KRD3.1
#=GS A1WBZ5_ACISJ/6-188        AC A1WBZ5.1
#=GS F3KI78_9ARCH/1-186        AC F3KI78.1
#=GS W8QX65_PSEST/5-184        AC W8QX65.1
#=GS D7I3U4_PSESS/5-185        AC D7I3U4.1
#=GS F2JWA6_MARM1/2-177        AC F2JWA6.1
#=GS A0A089N1Q3_9BACL/3-184    AC A0A089N1Q3.1
#=GS T2G831_DESGI/3-172        AC T2G831.1
#=GS Q3IXN5_RHOS4/7-186        AC Q3IXN5.1
#=GS U3U6F9_9ENTR/1-172        AC U3U6F9.1
#=GS A0A0C9N2Z6_SPHPI/7-186    AC A0A0C9N2Z6.1
#=GS A4CNQ6_ROBBH/3-157        AC A4CNQ6.1
#=GS D9SHI1_GALCS/4-183        AC D9SHI1.1
#=GS R7N9G0_9FIRM/14-180       AC R7N9G0.1
#=GS A5I5R4_CLOBH/4-185        AC A5I5R4.1
#=GS A0A0N0E504_9PSED/5-185    AC A0A0N0E504.1
#=GS B9JUW3_AGRVS/4-184        AC B9JUW3.1
#=GS Q6N0X2_RHOPA/6-189        AC Q6N0X2.1
#=GS J6IXH4_9RHOB/6-181        AC J6IXH4.1
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Q8ZLX9_SALTY/5-182                   .......................................NI.KIRSKLF..MA..FGL.F..IVL....M.VVSS....ALSL...F.SL...D..R...ANT..G..M..QN..I..I..T...N...D...Y....P....T..T.V.K.ANL.L.I....D....N....F....N....D....F..I...I.A...Q...Q...L.............M...L......L...D.....E...........E....G...RW..............SQ...S.....S....Q.......K....E...L.......D...E...I.......S.....Q.....R.......I...T....A..L...L....D....E.....L......S.......S.......N.....R.....H..........D..........A.......A.....S.....QK...II.T...E..I...RE...A...R.Q.Q.Y....LE.S.....R....F....R.....I....L..Q.....D...I.....Q....S.....H.N..R.Q................AA...I.Q....E....M...M......T.R.T.V........QVQ...K.V...Y...K...D...K.V...Q.E..L.IA.VQ.D...A..Q.------------mhnagvqve................................................................................
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Q2JYJ5_RHIEC/3-183                   .....................................