GenomeNet

Database: Pfam
Entry: A1_Propeptide
LinkDB: A1_Propeptide
Original site: A1_Propeptide 
#=GF ID   A1_Propeptide
#=GF AC   PF07966.10
#=GF DE   A1 Propeptide 
#=GF AU   Rawlings ND, Finn RD
#=GF SE   Pfam-B_386 (release 15.0)
#=GF GA   20.50 20.50;
#=GF TC   20.50 20.50;
#=GF NC   20.10 20.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Motif
#=GF RN   [1]
#=GF RM   1594574
#=GF RT   The high-resolution crystal structure of porcine pepsinogen. 
#=GF RA   Hartsuck JA, Koelsch G, Remington SJ; 
#=GF RL   Proteins 1992;13:1-25.
#=GF RN   [2]
#=GF RM   2056534
#=GF RT   Refined structure of porcine pepsinogen at 1.8 A resolution. 
#=GF RA   Sielecki AR, Fujinaga M, Read RJ, James MN; 
#=GF RL   J Mol Biol 1991;219:671-692.
#=GF DR   INTERPRO; IPR012848;
#=GF CC   Most eukaryotic endopeptidases (Merops Family A1) are
#=GF CC   synthesised with signal and propeptides.  The animal pepsin-like
#=GF CC   endopeptidase propeptides form a distinct family of propeptides,
#=GF CC   which contain a conserved motif approximately 30 residues long.
#=GF CC   In pepsinogen A, the first 11 residues of the mature pepsin
#=GF CC   sequence are displaced by residues of the propeptide.  The
#=GF CC   propeptide contains two helices that block the active site
#=GF CC   cleft, in particular the conserved Asp11 residue, in pepsin,
#=GF CC   hydrogen bonds to a conserved Arg residues in the propeptide. 
#=GF CC   This hydrogen bond stabilises the propeptide conformation and is
#=GF CC   probably responsible for triggering the conversion of pepsinogen
#=GF CC   to pepsin under acidic conditions [1,2].
#=GF SQ   572
#=GS G3UR66_MELGA/23-50        AC G3UR66.1
#=GS M7BRZ9_CHEMY/17-45        AC M7BRZ9.1
#=GS H2ME87_ORYLA/21-49        AC H2ME87.1
#=GS G1L2A2_AILME/31-51        AC G1L2A2.1
#=GS H2U4P5_TAKRU/20-48        AC H2U4P5.1
#=GS F1MR25_BOVIN/32-60        AC F1MR25.2
#=GS W5P811_SHEEP/16-44        AC W5P811.1
#=GS G5E572_BOVIN/12-44        AC G5E572.1
#=GS H2ME90_ORYLA/21-49        AC H2ME90.1
#=GS H0XYN6_OTOGA/1-27         AC H0XYN6.1
#=GS Q9TTV9_BOVIN/16-44        AC Q9TTV9.1
#=GS I3LG46_PIG/1-28           AC I3LG46.1
#=GS PEPC_HUMAN/18-46          AC P20142.1
#=GS PEPC_HUMAN/18-46          DR PDB; 1AVF Q; 2-22;
#=GS PEPC_HUMAN/18-46          DR PDB; 1AVF P; 2-21;
#=GS PEPC_HUMAN/18-46          DR PDB; 1HTR P; 2-30;
#=GS CHYM_FELCA/3-27           AC P09873.1
#=GS F1MWS3_BOVIN/19-47        AC F1MWS3.2
#=GS S9WK84_9CETA/30-55        AC S9WK84.1
#=GS U3KC12_FICAL/17-45        AC U3KC12.1
#=GS F6WZX8_CALJA/16-44        AC F6WZX8.1
#=GS F6WI91_HORSE/17-45        AC F6WI91.1
#=GS W5M2V9_LEPOC/19-47        AC W5M2V9.1
#=GS G1SHB1_RABIT/17-45        AC G1SHB1.1
#=GS E1BHR0_BOVIN/1-29         AC E1BHR0.2
#=GS D6WC03_TRICA/19-48        AC D6WC03.1
#=GS F1S636_PIG/17-45          AC F1S636.2
#=GS W5P1V0_SHEEP/16-44        AC W5P1V0.1
#=GS W5NH59_LEPOC/17-45        AC W5NH59.1
#=GS G3V8C5_RAT/18-47          AC G3V8C5.1
#=GS Q5HZD5_XENTR/17-45        AC Q5HZD5.1
#=GS F6ZL70_XENTR/8-37         AC F6ZL70.1
#=GS M3W8G3_FELCA/17-44        AC M3W8G3.1
#=GS H0X5R5_OTOGA/33-51        AC H0X5R5.1
#=GS B4LMK5_DROVI/24-53        AC B4LMK5.1
#=GS H2U4P6_TAKRU/31-59        AC H2U4P6.1
#=GS F1RIC8_PIG/16-44          AC F1RIC8.1
#=GS W4YHY4_STRPU/18-38        AC W4YHY4.1
#=GS U4UGL3_DENPD/21-50        AC U4UGL3.1
#=GS F7GFA0_CALJA/17-46        AC F7GFA0.1
#=GS H3B4C2_LATCH/20-46        AC H3B4C2.1
#=GS A0A0P7WH79_9TELE/2-28     AC A0A0P7WH79.1
#=GS CATE_MOUSE/22-50          AC P70269.2
#=GS F7E8F9_XENTR/10-39        AC F7E8F9.1
#=GS G3PP50_GASAC/17-45        AC G3PP50.1
#=GS A0A0P7UB51_9TELE/1-18     AC A0A0P7UB51.1
#=GS Q562D2_XENTR/17-45        AC Q562D2.1
#=GS F1RIC9_PIG/32-60          AC F1RIC9.2
#=GS L5LDF2_MYODS/30-50        AC L5LDF2.1
#=GS F6QR04_MONDO/19-47        AC F6QR04.2
#=GS G1PTZ9_MYOLU/21-49        AC G1PTZ9.1
#=GS H2U4L1_TAKRU/21-50        AC H2U4L1.1
#=GS PEPA4_HUMAN/17-45         AC P0DJD7.1
#=GS G5BX53_HETGA/21-49        AC G5BX53.1
#=GS W5NQU5_SHEEP/13-42        AC W5NQU5.1
#=GS W5LCP8_ASTMX/18-46        AC W5LCP8.1
#=GS H0Y0C1_OTOGA/16-44        AC H0Y0C1.1
#=GS W5QDV4_SHEEP/19-47        AC W5QDV4.1
#=GS W5Q4P6_SHEEP/37-65        AC W5Q4P6.1
#=GS A0A0D9RBZ8_CHLSB/21-50    AC A0A0D9RBZ8.1
#=GS PEPA_PIG/16-44            AC P00791.3
#=GS PEPA_PIG/16-44            DR PDB; 2PSG A; 1-29;
#=GS PEPA_PIG/16-44            DR PDB; 3PSG A; 1-29;
#=GS Q9JJX2_RAT/16-44          AC Q9JJX2.1
#=GS G3QD35_GORGO/18-46        AC G3QD35.1
#=GS G3QES7_GORGO/21-49        AC G3QES7.1
#=GS Q9D106_MOUSE/16-44        AC Q9D106.1
#=GS CATD_HUMAN/21-50          AC P07339.1
#=GS H3ABJ7_LATCH/1-25         AC H3ABJ7.1
#=GS E9IL23_SOLIN/1-26         AC E9IL23.1
#=GS E1B803_BOVIN/17-43        AC E1B803.2
#=GS G1SG52_RABIT/17-45        AC G1SG52.1
#=GS U4USP0_DENPD/21-50        AC U4USP0.1
#=GS I3KUE2_ORENI/18-46        AC I3KUE2.1
#=GS I3LTU5_PIG/16-44          AC I3LTU5.1
#=GS H2R877_PANTR/31-51        AC H2R877.1
#=GS F6SQ46_MONDO/18-46        AC F6SQ46.1
#=GS M4AVA9_XIPMA/19-48        AC M4AVA9.1
#=GS G1Q8B6_MYOLU/16-44        AC G1Q8B6.1
#=GS L5LXE3_MYODS/19-47        AC L5LXE3.1
#=GS A0A0R4INF8_DANRE/47-75    AC A0A0R4INF8.1
#=GS G7NVE5_MACFA/31-51        AC G7NVE5.1
#=GS G3X6M5_BOVIN/16-44        AC G3X6M5.1
#=GS W5PFK2_SHEEP/32-60        AC W5PFK2.1
#=GS G1MUX3_MELGA/30-55        AC G1MUX3.2
#=GS M0QW23_BOVIN/16-44        AC M0QW23.1
#=GS PEPC_CAVPO/18-46          AC Q64411.1
#=GS F1MYU5_BOVIN/16-44        AC F1MYU5.1
#=GS H2QSZ6_PANTR/18-46        AC H2QSZ6.1
#=GS A7RH56_NEMVE/1-30         AC A7RH56.1
#=GS M3XYS9_MUSPF/14-42        AC M3XYS9.1
#=GS G1U5K8_RABIT/19-47        AC G1U5K8.1
#=GS H0WKF2_OTOGA/21-50        AC H0WKF2.1
#=GS W5P808_SHEEP/32-60        AC W5P808.1
#=GS F1NRA9_CHICK/17-45        AC F1NRA9.1
#=GS F1MZL4_BOVIN/31-51        AC F1MZL4.1
#=GS G1Q1G4_MYOLU/16-44        AC G1Q1G4.1
#=GS W5N2H0_LEPOC/29-49        AC W5N2H0.1
#=GS W5NTQ2_SHEEP/14-41        AC W5NTQ2.1
#=GS G3N0Q4_BOVIN/13-40        AC G3N0Q4.1
#=GS A2A3L9_HUMAN/19-50        AC A2A3L9.1
#=GS M3XXL6_MUSPF/22-50        AC M3XXL6.1
#=GS G3USD2_MELGA/26-50        AC G3USD2.1
#=GS M0QVY5_BOVIN/14-43        AC M0QVY5.1
#=GS B4HR82_DROSE/27-56        AC B4HR82.1
#=GS G1TER8_RABIT/16-45        AC G1TER8.1
#=GS G1KN80_ANOCA/17-45        AC G1KN80.2
#=GS G3WA97_SARHA/19-47        AC G3WA97.1
#=GS F6Q3A5_BOVIN/16-44        AC F6Q3A5.1
#=GS G1SGA0_RABIT/21-49        AC G1SGA0.2
#=GS U3IJJ9_ANAPL/17-39        AC U3IJJ9.1
#=GS H0VCH6_CAVPO/21-49        AC H0VCH6.1
#=GS L5JWB3_PTEAL/21-40        AC L5JWB3.1
#=GS H3CFR9_TETNG/17-42        AC H3CFR9.1
#=GS G1KVT2_ANOCA/17-45        AC G1KVT2.1
#=GS W5N1C8_LEPOC/17-45        AC W5N1C8.1
#=GS F6RFU0_XENTR/13-46        AC F6RFU0.1
#=GS F7EUW5_ORNAN/1-32         AC F7EUW5.1
#=GS F7E8J7_MACMU/21-49        AC F7E8J7.1
#=GS G3N0E0_BOVIN/16-44        AC G3N0E0.1
#=GS W5KK44_ASTMX/11-44        AC W5KK44.1
#=GS PEPC_MOUSE/18-46          AC Q9D7R7.1
#=GS W5P0I1_SHEEP/16-44        AC W5P0I1.1
#=GS Q8AWD9_DANRE/19-45        AC Q8AWD9.1
#=GS PAG4_SHEEP/16-44          AC P83495.2
#=GS G3UBF6_LOXAF/12-45        AC G3UBF6.1
#=GS H0X9S5_OTOGA/16-44        AC H0X9S5.1
#=GS W5NW79_SHEEP/31-60        AC W5NW79.1
#=GS F7HL24_MACMU/26-54        AC F7HL24.1
#=GS G3TG08_LOXAF/31-51        AC G3TG08.1
#=GS B7ZWD6_MOUSE/18-47        AC B7ZWD6.1
#=GS I3MDT9_ICTTR/21-49        AC I3MDT9.1
#=GS RENI_CANLF/30-50          AC Q6DYE7.1
#=GS H0XYD8_OTOGA/16-43        AC H0XYD8.1
#=GS F7IFP6_CALJA/16-44        AC F7IFP6.1
#=GS G3X8A4_BOVIN/17-46        AC G3X8A4.1
#=GS A5PJW4_BOVIN/16-44        AC A5PJW4.1
#=GS H2NCE8_PONAB/1-28         AC H2NCE8.1
#=GS M4ARK5_XIPMA/24-52        AC M4ARK5.1
#=GS H1A4D5_TAEGU/5-31         AC H1A4D5.1
#=GS V8PCR8_OPHHA/17-45        AC V8PCR8.1
#=GS A0A093BI66_CHAPE/1-27     AC A0A093BI66.1
#=GS F1MJ49_BOVIN/16-44        AC F1MJ49.2
#=GS G3X7G1_BOVIN/1-20         AC G3X7G1.1
#=GS Q4VXA6_HUMAN/18-46        AC Q4VXA6.7
#=GS W5PPE5_SHEEP/34-62        AC W5PPE5.1
#=GS M3VZC9_FELCA/31-51        AC M3VZC9.1
#=GS PEPA_CALJA/16-44          AC Q9N2D4.1
#=GS Q292G7_DROPS/23-52        AC Q292G7.1
#=GS A0A0P7V514_9TELE/72-100   AC A0A0P7V514.1
#=GS M3WZ94_FELCA/19-47        AC M3WZ94.1
#=GS H2N424_PONAB/31-51        AC H2N424.2
#=GS W5L0G6_ASTMX/18-37        AC W5L0G6.1
#=GS CHYM_SHEEP/19-47          AC P18276.1
#=GS M7C7F6_CHEMY/17-45        AC M7C7F6.1
#=GS Q9TTV3_BOVIN/16-44        AC Q9TTV3.1
#=GS B4KSY7_DROMO/22-51        AC B4KSY7.1
#=GS H0X8A6_OTOGA/19-46        AC H0X8A6.1
#=GS CATD_CANLF/21-50          AC Q4LAL9.1
#=GS F7EGJ5_XENTR/24-44        AC F7EGJ5.1
#=GS G1MWJ2_MELGA/23-51        AC G1MWJ2.2
#=GS A0A091D835_FUKDA/21-50    AC A0A091D835.1
#=GS A3KN11_BOVIN/16-44        AC A3KN11.1
#=GS G1KIV8_ANOCA/19-44        AC G1KIV8.2
#=GS G1PBM4_MYOLU/30-50        AC G1PBM4.1
#=GS A0A067RRR8_ZOONE/18-46    AC A0A067RRR8.1
#=GS H2R344_PANTR/21-49        AC H2R344.1
#=GS G3N0Z2_BOVIN/12-39        AC G3N0Z2.1
#=GS G3UPX4_MELGA/20-47        AC G3UPX4.1
#=GS F7IMD9_CALJA/21-49        AC F7IMD9.1
#=GS G1KX50_ANOCA/18-46        AC G1KX50.1
#=GS PEPA3_RABIT/17-45         AC P27822.1
#=GS M0QW08_BOVIN/16-44        AC M0QW08.1
#=GS F6RFS6_XENTR/22-50        AC F6RFS6.1
#=GS G3NEI1_GASAC/24-53        AC G3NEI1.1
#=GS CATE_CAVPO/21-49          AC P25796.1
#=GS W5PJB4_SHEEP/32-60        AC W5PJB4.1
#=GS F1N373_BOVIN/17-45        AC F1N373.2
#=GS G3S939_GORGO/19-44        AC G3S939.1
#=GS I3N9H0_ICTTR/19-47        AC I3N9H0.1
#=GS F1ML46_BOVIN/16-44        AC F1ML46.2
#=GS A0A0P7V514_9TELE/437-456  AC A0A0P7V514.1
#=GS H2MSN2_ORYLA/15-43        AC H2MSN2.1
#=GS F7HNZ5_CALJA/21-50        AC F7HNZ5.1
#=GS E2R9E5_CANLF/19-47        AC E2R9E5.1
#=GS I3KNQ1_ORENI/17-45        AC I3KNQ1.1
#=GS L5MFU3_MYODS/21-49        AC L5MFU3.1
#=GS H9G9A1_ANOCA/17-45        AC H9G9A1.1
#=GS W4WY81_ATTCE/26-56        AC W4WY81.1
#=GS F4WNQ0_ACREC/14-46        AC F4WNQ0.1
#=GS H3C9K9_TETNG/19-48        AC H3C9K9.1
#=GS A0A0K0JWL1_BRUMA/30-57    AC A0A0K0JWL1.1
#=GS L9KR36_TUPCH/19-47        AC L9KR36.1
#=GS PAG2_PIG/16-44            AC Q29079.1
#=GS E2RJN2_CANLF/21-49        AC E2RJN2.2
#=GS A0A087XHQ9_POEFO/21-49    AC A0A087XHQ9.1
#=GS G1U3N9_RABIT/18-46        AC G1U3N9.1
#=GS R4GL36_CHICK/17-44        AC R4GL36.1
#=GS Q7K485_DROME/27-56        AC Q7K485.1
#=GS L9KTD9_TUPCH/18-46        AC L9KTD9.1
#=GS G3U597_LOXAF/20-49        AC G3U597.1
#=GS B4MPC4_DROWI/24-53        AC B4MPC4.1
#=GS H2U4L2_TAKRU/19-48        AC H2U4L2.1
#=GS W5NVC7_SHEEP/32-60        AC W5NVC7.1
#=GS A0A087X773_POEFO/19-48    AC A0A087X773.2
#=GS L9LAI8_TUPCH/21-49        AC L9LAI8.1
#=GS W5L0D2_ASTMX/20-40        AC W5L0D2.1
#=GS B4GDK1_DROPE/23-52        AC B4GDK1.1
#=GS F1PE75_CANLF/17-45        AC F1PE75.1
#=GS G1NPE0_MELGA/17-45        AC G1NPE0.1
#=GS K7J796_NASVI/19-48        AC K7J796.1
#=GS F7C9L7_MONDO/19-47        AC F7C9L7.2
#=GS RENI2_MOUSE/28-48         AC P00796.1
#=GS A0A087Y1P3_POEFO/17-45    AC A0A087Y1P3.2
#=GS F6THW3_MACMU/31-51        AC F6THW3.1
#=GS W5PPL1_SHEEP/17-45        AC W5PPL1.1
#=GS H0XEM4_OTOGA/17-45        AC H0XEM4.1
#=GS G1TKZ8_RABIT/18-46        AC G1TKZ8.1
#=GS A0A0D9RPN0_CHLSB/31-51    AC A0A0D9RPN0.1
#=GS G1L5H8_AILME/26-55        AC G1L5H8.1
#=GS G3N7P3_GASAC/17-45        AC G3N7P3.1
#=GS G3WIA3_SARHA/17-45        AC G3WIA3.1
#=GS G1RVK2_NOMLE/31-51        AC G1RVK2.1
#=GS A4IFS5_BOVIN/16-44        AC A4IFS5.1
#=GS G3N0B4_BOVIN/32-60        AC G3N0B4.1
#=GS W5P828_SHEEP/16-46        AC W5P828.1
#=GS G3TA26_LOXAF/17-45        AC G3TA26.1
#=GS PEPA_MACMU/16-45          AC P11489.1
#=GS S9YQF9_9CETA/16-45        AC S9YQF9.1
#=GS F7BW04_ORNAN/17-45        AC F7BW04.2
#=GS L5JXS5_PTEAL/21-49        AC L5JXS5.1
#=GS E3NSK7_CAERE/18-46        AC E3NSK7.1
#=GS M3YPZ3_MUSPF/18-46        AC M3YPZ3.1
#=GS F8WD96_HUMAN/21-50        AC F8WD96.1
#=GS W5LMA9_ASTMX/19-48        AC W5LMA9.1
#=GS G3NZN2_GASAC/27-54        AC G3NZN2.1
#=GS G3U1Z4_LOXAF/9-36         AC G3U1Z4.1
#=GS PEPA5_HUMAN/17-45         AC P0DJD9.1
#=GS F1RIE6_PIG/16-44          AC F1RIE6.2
#=GS G3UNI4_LOXAF/20-45        AC G3UNI4.1
#=GS W5N1C1_LEPOC/18-46        AC W5N1C1.1
#=GS F7GKP1_MONDO/17-45        AC F7GKP1.1
#=GS D2I0K6_AILME/17-45        AC D2I0K6.1
#=GS W5P3R9_SHEEP/16-44        AC W5P3R9.1
#=GS H0XCT4_OTOGA/15-47        AC H0XCT4.1
#=GS F7IPN1_CALJA/21-49        AC F7IPN1.1
#=GS I3KL05_ORENI/24-52        AC I3KL05.1
#=GS W5PNT1_SHEEP/21-49        AC W5PNT1.1
#=GS F1RIE7_PIG/16-44          AC F1RIE7.2
#=GS I3MWS9_ICTTR/1-27         AC I3MWS9.1
#=GS G3TIB5_LOXAF/19-46        AC G3TIB5.1
#=GS M0QVZ0_BOVIN/16-44        AC M0QVZ0.1
#=GS PAG1_BOVIN/16-44          AC Q29432.1
#=GS J9NYW4_CANLF/16-44        AC J9NYW4.1
#=GS I3M846_ICTTR/20-48        AC I3M846.1
#=GS G1T1U4_RABIT/17-45        AC G1T1U4.1
#=GS W5NSL3_SHEEP/16-44        AC W5NSL3.1
#=GS F7H7Y3_MACMU/21-50        AC F7H7Y3.1
#=GS W5NVC2_SHEEP/32-60        AC W5NVC2.1
#=GS M0QW24_BOVIN/16-44        AC M0QW24.1
#=GS G1KB82_ANOCA/17-45        AC G1KB82.1
#=GS F1RUW7_PIG/18-46          AC F1RUW7.1
#=GS F8W366_DANRE/19-45        AC F8W366.1
#=GS W5PJC0_SHEEP/13-41        AC W5PJC0.1
#=GS H0XM18_OTOGA/16-44        AC H0XM18.1
#=GS RENI_MACMU/31-51          AC Q6DLW5.2
#=GS G1TM78_RABIT/17-45        AC G1TM78.1
#=GS G1LYC3_AILME/19-47        AC G1LYC3.1
#=GS C3YBT8_BRAFL/17-43        AC C3YBT8.1
#=GS H3B127_LATCH/17-45        AC H3B127.1
#=GS M4A7P5_XIPMA/17-45        AC M4A7P5.1
#=GS M3YJR7_MUSPF/33-51        AC M3YJR7.1
#=GS F7EHV9_XENTR/17-47        AC F7EHV9.1
#=GS F6UM82_HORSE/17-45        AC F6UM82.1
#=GS I3LSA4_PIG/19-47          AC I3LSA4.1
#=GS M7BRZ9_CHEMY/97-122       AC M7BRZ9.1
#=GS F6Q1N6_HORSE/21-49        AC F6Q1N6.1
#=GS W5P802_SHEEP/23-56        AC W5P802.1
#=GS L8Y1V8_TUPCH/16-39        AC L8Y1V8.1
#=GS G4VEV7_SCHMA/15-46        AC G4VEV7.1
#=GS PEPA_CHICK/2-30           AC P00793.1
#=GS W5N1D9_LEPOC/18-46        AC W5N1D9.1
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G3UR66_MELGA/23-50                   .............LH..RIKLKKGKSIREKMRE.A...GVLEEYLKK-.........
M7BRZ9_CHEMY/17-45                   .............LV..RIPMRKFKSMRQVMKE.K...GVLKDYLKNH.........
H2ME87_ORYLA/21-49                   .............LI..RVPLHKTRSLRRLMSDnG...MSLDDLRA--l........
G1L2A2_AILME/31-51                   ...........fq--..RIFLKKMPSIRESLKE.R...GV--------.........
H2U4P5_TAKRU/20-48                   ............l-L..IITLHKMPSIRETLGEmG...VSVEQVLS--e........
F1MR25_BOVIN/32-60                   .............IV..KIPLRRVKTMRKTLSG.K...NMLKDFLKEH.........
W5P811_SHEEP/16-44                   .............IF..KIPLRRVKTMRKTLSG.K...NMLNDVLKEH.........
G5E572_BOVIN/12-44                   ..........yim--..KIPLRRVKTMRKTLTE.KkkkNILNNFLKKH.........
H2ME90_ORYLA/21-49                   .............LI..RVPLHKTRSLRRLMSDnG...MSLDDLRA--l........
H0XYN6_OTOGA/1-27                    .............--..RVPLMKVKSMRENLQE.N...GMLKEYLEKY.........
Q9TTV9_BOVIN/16-44                   .............VV..KIPLRRVKTMTKTLSG.K...NMLNNFLKEH.........
I3LG46_PIG/1-28                      .............--..RIPLHKFTSIRRTMSEvG...GPVENLIAK-g........
PEPC_HUMAN/18-46                     .............VV..KVPLKKFKSIRETMKE.K...GLLGEFLRTH.........
#=GR PEPC_HUMAN/18-46          SS    .............-E..EEEEEE---HHHHHHH.T...T-HHHHHTT-.........
CHYM_FELCA/3-27                      .............IT..RVPLHKGKSLRKALKE.H...GLLEBF----.........
F1MWS3_BOVIN/19-47                   .............LV..KIPLKKFKSIREIMKE.K...GLLEDFLRTY.........
S9WK84_9CETA/30-55                   .............--..-VPLKKFKSVRETMKE.K...GLLEEFLRTH.........
U3KC12_FICAL/17-45                   ............q-T..RVPLRKMKSLRQRLQE.Q...GLLESYLKQH.........
F6WZX8_CALJA/16-44                   .............LY..KVSLIKKKSLRKNLIE.H...GLLKDFLKN-n........
F6WI91_HORSE/17-45                   .............IY..KVPLVKKKSLRQNLRE.N...GLLADFLKQH.........
W5M2V9_LEPOC/19-47                   .............II..RIPLKKFRSIRRSLSDvG...KSVEEL----vad......
G1SHB1_RABIT/17-45                   .............IH..KVPLVRKKSLRKNLIE.K...GLLKDYLKTH.........
E1BHR0_BOVIN/1-29                    .............MV..IIPLRQMKTMRETLRE.R...NLLTNFSEEH.........
D6WC03_TRICA/19-48                   .............FV..RVPLYKVKSARRSLQEvG...THVQQVRMR-y........
F1S636_PIG/17-45                     ............m-E..RIILRKGKSIREAMEE.Q...GVLEKFLKN-r........
W5P1V0_SHEEP/16-44                   .............IV..KIPLRRVKTMRNTVSG.K...NMMNNFLKEH.........
W5NH59_LEPOC/17-45                   .............LT..RIPLKRFSSVRQELRA.T...QQLENYLRDH.........
G3V8C5_RAT/18-47                     ............vVT..RIPLHKGKSLRNTLKE.Q...GLLEDFLRRH.........
Q5HZD5_XENTR/17-45                   .............LV..RVPLKRFKSTRETMKE.N...GVLNDFLKTH.........
F6ZL70_XENTR/8-37                    ...........ly-Y..RVPLKRFKSTRETMKE.N...GVLNDFLKTH.........
M3W8G3_FELCA/17-44                   .............--..RIPLHKFTSVRRTMSElG...GPVEDLIAK-g........
H0X5R5_OTOGA/33-51                   .............--..RIFLKKMPSVREKLKE.R...GV--------.........
B4LMK5_DROVI/24-53                   .............LL..RVPLNKFQSARRHFADvG...TELQQLRIKY.........
H2U4P6_TAKRU/31-59                   .............LR..RITLHKMPSIRETLGEmG...VSVEQVLS--e........
F1RIC8_PIG/16-44                     .............LV..IIPLMKVKSIRENLRE.K...GLLENFLEEH.........
W4YHY4_STRPU/18-38                   .............LV..RVPLYKMETVRRQMAN.-...----------tgl......
U4UGL3_DENPD/21-50                   .............LV..RVPLTKGKSPKNILREvG...THVQQVK---lry......
F7GFA0_CALJA/17-46                   ...........yn-H..RVSLIKKKSLRKNLIE.H...GLLKDFLKN-n........
H3B4C2_LATCH/20-46                   .............II..RIPLRKFRTMRRTMSDgR...MSIEE-----lk.......
A0A0P7WH79_9TELE/2-28                .............--..KVPLIKGKTVRETMEE.K...GLWEDFRQKY.........
CATE_MOUSE/22-50                     .............LH..RVPLRRHQSLRKKLRA.Q...GQLSEFWRSH.........
F7E8F9_XENTR/10-39                   .........tcnt--..-VPLMKSKSIRQNMAE.A...GVLDKYLQTH.........
G3PP50_GASAC/17-45                   .............LI..RVPLKRVRSVRSQLRV.E...GLLEEFLKEH.........
A0A0P7UB51_9TELE/1-18                .............--..-VPLTKTKSIRKRLQE.Q...GV--------.........
Q562D2_XENTR/17-45                   .............LV..RVPLKRYKSARDIMRE.R...GILKEFMKTH.........
F1RIC9_PIG/32-60                     .............LV..TIPLRKVKSIRENLRD.K...GLLKNFLEEH.........
L5LDF2_MYODS/30-50                   ............f-R..RIFLKKMPSVRESLKE.R...GV--------.........
F6QR04_MONDO/19-47                   .............II..KVPLKRFKSMKQVMKE.K...GVWQDFQKSH.........
G1PTZ9_MYOLU/21-49                   .............LH..RVPLRRGQSLRKKLRA.R...GQLSEFWKSQ.........
H2U4L1_TAKRU/21-50                   .............LV..RIPLKKFRSIRRELTDsG...RKIEELLAD-r........
PEPA4_HUMAN/17-45                    .............MY..KVPLIRKKSLRRTLSE.R...GLLKDFLKKH.........
G5BX53_HETGA/21-49                   .............LH..RVPLQRHESLRKKLRA.Q...GQLTDFWKSQ.........
W5NQU5_SHEEP/13-42                   .............IV..IIPLRKVKTMQEILSEkK...NLLNNFLEEH.........
W5LCP8_ASTMX/18-46                   .............LV..RIPLTKAPSLRSHLRA.K...NQLEDFLKDH.........
H0Y0C1_OTOGA/16-44                   .............LV..RVPLIKVKSMRENLQE.N...GMLKEYLEKY.........
W5QDV4_SHEEP/19-47                   .............IT..RIPLYKGKPLRKALKE.R...GLLEDFLQKQ.........
W5Q4P6_SHEEP/37-65                   .............MV..IIPIMKMKTMRETLRE.R...SLLTNFSEEH.........
A0A0D9RBZ8_CHLSB/21-50               .............LI..RIPLHKFTSIRRTMSEmG...GPVEDLIAK-g........
PEPA_PIG/16-44                       .............LV..KVPLVRKKSLRQNLIK.N...GKLKDFLKTH.........
#=GR PEPA_PIG/16-44            SS    .............-E..EEEEEE---HHHHHHH.T...T-HHHHHHH-.........
Q9JJX2_RAT/16-44                     .............LV..KIPLMKIKSMRENLRE.S...HMLKDYLEKY.........
G3QD35_GORGO/18-46                   .............MY..KVPLIRKKSLRRTLSE.R...GLLKDFLKKH.........
G3QES7_GORGO/21-49                   .............LH..RVPLRRHPSLKKKLRA.R...SQLSEFWKSH.........
Q9D106_MOUSE/16-44                   .............LV..KIPLMKIKSMRENLRE.S...QVLKDYLEKY.........
CATD_HUMAN/21-50                     .............LV..RIPLHKFTSIRRTMSEvG...GSVEDLIAK-g........
H3ABJ7_LATCH/1-25                    .............--..RIQLKKMPSIRQTLSEiR...VKMGDVL---.........
E9IL23_SOLIN/1-26                    .............--..RIPLQKTESVRNALRKvG...TELTQVR---l........
E1B803_BOVIN/17-43                   .............-V..IIPLRKVKTMRNTLS-.K...NMLNNFLKEH.........
G1SG52_RABIT/17-45                   .............IH..KVPLVRKKSLRKNLIE.K...GLLKDYLKTH.........
U4USP0_DENPD/21-50                   .............LV..RVPLTKGKSPKNILREvG...THVQQVK---lry......
I3KUE2_ORENI/18-46                   .............LV..QIPLEKGKSAREVLEE.Q...GLWEEYRQKY.........
I3LTU5_PIG/16-44                     .............LV..MIPLRKVKSIRENLRD.K...GLLKNFLGEH.........
H2R877_PANTR/31-51                   ...........fk--..RIFLKRMPSIRESLKE.R...GV--------.........
F6SQ46_MONDO/18-46                   ............f-R..RIPLTKGKTLRKVLKE.H...GLLESFLKSH.........
M4AVA9_XIPMA/19-48                   .............LV..RIPLKKFRSIRRELTDsG...RRADELLA--dr.......
G1Q8B6_MYOLU/16-44                   .............LV..TVPLMKIKSMRETLRE.R...DLLRDYLQRH.........
L5LXE3_MYODS/19-47                   .............IT..RIPLHKGKSIRRALRE.R...GLLEDFLRTH.........
A0A0R4INF8_DANRE/47-75               .............LL..RVALRQYPSVRSRLRA.S...AQLEEFLKQH.........
G7NVE5_MACFA/31-51                   ...........fk--..RIFLKRMPSIRESLKE.R...GV--------.........
G3X6M5_BOVIN/16-44                   .............IV..KIPLRRLKTMRKTLSG.K...NMLKDFLKEH.........
W5PFK2_SHEEP/32-60                   .............IV..KIPLKRVKTMRNTVSG.R...NMLNNFVKEH.........
G1MUX3_MELGA/30-55                   ............l-Q..RIALRRMPSIRQTLQEmG...VKVSD-----v........
M0QW23_BOVIN/16-44                   .............IV..KIPLRRVKTMTKTLSG.K...NMLNNFVKEH.........
PEPC_CAVPO/18-46                     ............q-I..KVPLKKIKSIREVLRE.K...GLLGDFLKNH.........
F1MYU5_BOVIN/16-44                   .............IF..KIPLRRVKTMRKTLSG.K...NMLNNFLKEH.........
H2QSZ6_PANTR/18-46                   .............VV..KVPLKKFKSIRETMKE.K...GLLGEFLRTH.........
A7RH56_NEMVE/1-30                    ............f-Y..RIPLHKMPTPRQSLKEvG...ISVEQLLGKY.........
M3XYS9_MUSPF/14-42                   .............LC..RIILKKGKSIRQVMKE.R...GVLDTFLKNH.........
G1U5K8_RABIT/19-47                   .............IT..RIPLYKGNTLRKALKE.H...GLLGDFLKKH.........
H0WKF2_OTOGA/21-50                   .............LI..RIPLYKFKSIRRTMSEaA...GPVEELIAK-g........
W5P808_SHEEP/32-60                   .............IV..KIPLRRVKIMRNTLRG.K...NMLNNFLKEH.........
F1NRA9_CHICK/17-45                   .............IT..RLPLERGKKLREILRE.K...GLLHHFLQHH.........
F1MZL4_BOVIN/31-51                   ............f-R..RIFLKKMPSVRESLKE.R...GV--------.........
G1Q1G4_MYOLU/16-44                   .............LV..TVPLTKIKSMRETLRE.R...DLLRDYLQRH.........
W5N2H0_LEPOC/29-49                   .............LI..RISLKKMPSIRETLREmG...----------v........
W5NTQ2_SHEEP/14-41                   .............-V..IIPLTKVKTMRKTLSE.E...NMLNNFLKEH.........
G3N0Q4_BOVIN/13-40                   .............IV..IIPLTKVKTMREMLSE.K...KLAEQYL---gh.......
A2A3L9_HUMAN/19-50                   ........vickq--..RVPLKKFKSIRETMKE.K...GLLGEFLRTH.........
M3XXL6_MUSPF/22-50                   .............LH..RIPLHKGKSLRKVLKE.H...GLLEDFLKKH.........
G3USD2_MELGA/26-50                   ............r--..RIALRRMPSIRQTLQEmG...VKVSD-----v........
M0QVY5_BOVIN/14-43                   ............vIE..RTPLRKMKTMRNTFSE.K...NIMNNFLKEH.........
B4HR82_DROSE/27-56                   .............LL..RVPLHKFQSARRHFADvG...TELQQLR---iry......
G1TER8_RABIT/16-45                   ............iVH..KVPLVRKKSLRKNLIE.K...GLLQDYLKTH.........
G1KN80_ANOCA/17-45                   .............II..RIPLQRGKKGRNTLKE.N...GLLDSFLKEH.........
G3WA97_SARHA/19-47                   .............II..KVPLKRFKSMKQVMKE.K...GVLQDFLRNH.........
F6Q3A5_BOVIN/16-44                   .............MV..IIPLRQMKTMRETLRE.R...NLLTNFSEEH.........
G1SGA0_RABIT/21-49                   .............LH..RVPLRRQPSLRKKLRA.Q...GQLSEFWKAH.........
U3IJJ9_ANAPL/17-39                   .............-V..RIPLRRMKSLRHRLEE.Q...GLLE------a........
H0VCH6_CAVPO/21-49                   .............LI..RIPLHKFKSIRHTMTEaG...GSVENLI---ar.......
L5JWB3_PTEAL/21-40                   ............a--..RIFLKKMPSVRESLKE.R...GV--------.........
H3CFR9_TETNG/17-42                   .............LV..RVPLTRGKTARQVLED.L...GLWEEY----q........
G1KVT2_ANOCA/17-45                   .............LE..RVILKRGKSIRENMKE.K...GVLEEFLKK-n........
W5N1C8_LEPOC/17-45                   .............LH..KIPLIKGKSARQALEE.K...GLWEEYRKRH.........
F6RFU0_XENTR/13-46                   ......lvpslff--..RVPLHKSKTIRETMKE.K...GVLKEFMKTH.........
F7EUW5_ORNAN/1-32                    ........lvsvp--..RIPLHKGLSLRQVLEK.H...DLLAEFLKEH.........
F7E8J7_MACMU/21-49                   .............LH..RVPLRRHPSLKKKLRA.R...SQLSEFWKSQ.........
G3N0E0_BOVIN/16-44                   .............IV..IIPLTKVKTMRKTLSE.K...NMLNNFLKEQ.........
W5KK44_ASTMX/11-44                   ......valsecf--..KVQLIKGKSARERLRE.K...GLWEKYRLMH.........
PEPC_MOUSE/18-46                     .............LI..RVPLKKMKSIRETMKE.Q...GVLKDFLKNH.........
W5P0I1_SHEEP/16-44                   .............IV..KIPLRRVKTMRNTLSG.K...NMLNNFLKKH.........
Q8AWD9_DANRE/19-45                   .............IV..RIPLKKFRTLRRTLSDsG...RSLEEL----v........
PAG4_SHEEP/16-44                     .............IF..KIPLRRVKTMRKTLSG.K...NMLNDVLKEH.........
G3UBF6_LOXAF/12-45                   ......hlseglg--..RIILKKGKSLHQVMEE.Y...GVLETFLKNH.........
H0X9S5_OTOGA/16-44                   .............LV..RVPLMKVKSMREKLEE.N...GMLKEYLEN-q........
W5NW79_SHEEP/31-60                   ............f-R..RIFLKKMPSVRESLKE.R...GV--------dmaqlgaew
F7HL24_MACMU/26-54                   .............LL..RVPLHKGKSLRRTLKE.H...GLLEDFLRNH.........
G3TG08_LOXAF/31-51                   ............f-R..RIFLKKMPSVRESLKE.R...GV--------.........
B7ZWD6_MOUSE/18-47                   ............vVT..RIPLHKGKSLRNTLKE.Q...GLLEDFL---srq......
I3MDT9_ICTTR/21-49                   .............LH..RVALKRHQSLRKKLRA.R...GQLSEFWKSQ.........
RENI_CANLF/30-50                     ............f-R..RIFLKKMPSIRESLKE.R...GV--------.........
H0XYD8_OTOGA/16-43                   .............LV..RVPLMKVKSMRENLEE.N...GMLKEYLEK-.........
F7IFP6_CALJA/16-44                   .............LY..KVSLIKKKSLRKNLIE.H...GLLKDFLKN-n........
G3X8A4_BOVIN/17-46                   ............vIE..KIPLRKVKTMRNTFSE.K...NMLSNFLKEH.........
A5PJW4_BOVIN/16-44                   .............IV..KIPLRRVKTMRNAISG.K...NTLNNILKEH.........
H2NCE8_PONAB/1-28                    .............--..RIPLHKFTSIRRTMSEvG...GSVEDLIAK-g........
M4ARK5_XIPMA/24-52                   .............LR..RIALKKMPTIRETLQEtG...VSAEQV----mte......
H1A4D5_TAEGU/5-31                    ..........vpp--..RIALRRMPSIRQTLREmG...VK--------vrev.....
V8PCR8_OPHHA/17-45                   ............l-Q..RVTLKRHRSLRQILRE.R...GQLPQFWKKY.........
A0A093BI66_CHAPE/1-27                .............--..RVALTRQRSLRQSLRD.R...GQLSHFWEAH.........
F1MJ49_BOVIN/16-44                   .............IV..KIPLTKMKTMQEAIRE.K...QLLEDFLDEQ.........
G3X7G1_BOVIN/1-20                    .............--..-------KTMRKTLSG.K...NMLNNFLKEH.........
Q4VXA6_HUMAN/18-46                   .............VV..KVPLKKFKSIRETMKE.K...GLLGEFLRTH.........
W5PPE5_SHEEP/34-62                   .............IV..IMPLTKTKTMREILRE.K...NLLNNFLEEQ.........
M3VZC9_FELCA/31-51                   ............f-R..RIFLKKMPSIRESLKE.R...GV--------.........
PEPA_CALJA/16-44                     .............LY..KVSLIKKKSLRKNLIE.H...GLLKDFLKN-n........
Q292G7_DROPS/23-52                   .............LL..RVPLNRFQSARRHFADvG...TELQQLR---iry......
A0A0P7V514_9TELE/72-100              .............LH..KVPLIKGKTARMILKE.K...GLWEDFRKKY.........
M3WZ94_FELCA/19-47                   .............IT..RVPLHKGKSLRKALKE.H...GLLEDFLKEH.........
H2N424_PONAB/31-51                   ...........fk--..RIFLKRMPSIRESLKE.R...GV--------.........
W5L0G6_ASTMX/18-37                   .............-I..RVPLRKMKSIRQALRE.K...GI--------.........
CHYM_SHEEP/19-47                     .............IT..RIPLYKGKPLRKALKE.R...GLLEDFLQKQ.........
M7C7F6_CHEMY/17-45                   .............IE..RIPLVRFKSTKRQLRE.K...GELEEFLKNH.........
Q9TTV3_BOVIN/16-44                   .............IV..KIPLRRVKTMRKTLSG.K...NMLNNFLKEH.........
B4KSY7_DROMO/22-51                   .............LL..RVPLTKFQSVRRHFADvG...TELHQLRIKY.........
H0X8A6_OTOGA/19-46                   .............LH..RVPLTRYPSLRKKLQE.P...DQLSEFCK--s........
CATD_CANLF/21-50                     .............LV..RIPLHKFTSVRRTMTElG...GPVEDLIAK-g........
F7EGJ5_XENTR/24-44                   ............l-F..RIPLKKFPSIRRTLSD.-...----------smt......
G1MWJ2_MELGA/23-51                   ...........lk--..RVTLTRHRSLRKSLRD.R...GQLSQFWKAH.........
A0A091D835_FUKDA/21-50               .............LI..RIPLHKFTSIRRTMTEaG...GSIEDLIA--hg.......
A3KN11_BOVIN/16-44                   .............IV..KIPLRRVKTMRKTLSG.K...NMLNNFLKE-d........
G1KIV8_ANOCA/19-44                   .............LI..RIPLKKFPSPRSIYAEyG...TDLQDL----.........
G1PBM4_MYOLU/30-50                   ............f-R..RIILKKMPSVRESLKD.R...GV--------.........
A0A067RRR8_ZOONE/18-46               .............FV..RIPLYKFQSARRALQEaG...TDVHQIR---lt.......
H2R344_PANTR/21-49                   .............LH..RVPLRRHPSLKKKLRA.R...SQLSEFWKSH.........
G3N0Z2_BOVIN/12-39                   .............IV..KIPLTKVNVMRETLS-.K...TLLNNFLKEY.........
G3UPX4_MELGA/20-47                   .............MV..RIKLKKGKSIREKMRE.A...GVLEEYLKK-.........
F7IMD9_CALJA/21-49                   .............LH..RVPLRKHPSLKKRLRA.R...SQLSEFLKSQ.........
G1KX50_ANOCA/18-46                   .............VI..KVPLKKFKSMREVMKE.K...GVLDEFLKN-n........
PEPA3_RABIT/17-45                    .............IH..KVPLVRKKSLRKNLIE.K...GLLKDYLKTH.........
M0QW08_BOVIN/16-44                   .............IV..ILPLKKMKTLRETLRE.K...NLLNNFLEEQ.........
F6RFS6_XENTR/22-50                   .............LE..RVPLVKFKSIRSHLWQ.R...DELNEFWLHH.........
G3NEI1_GASAC/24-53                   .............LR..RVSLKKMPSIRETLSEmG...VSAEQVLTE-l........
CATE_CAVPO/21-49                     .............LH..RVPLSRRESLRKKLRA.Q...GQLTELWKSQ.........
W5PJB4_SHEEP/32-60                   .............IV..KIPLRRVKTMRNTISG.K...NILNSFLKEH.........
F1N373_BOVIN/17-45                   .............VV..KIPLVKKKSLRQNLIE.N...GKLKEFMRTH.........
G3S939_GORGO/19-44                   .............--..-VPLHKGKSLRRALKE.R...RLLEDFLRNH.........
I3N9H0_ICTTR/19-47                   .............VT..RIPLHKGKSLRSTLQD.L...GLLEDFLKKH.........
F1ML46_BOVIN/16-44                   .............IV..KIPLRQVKTMRKTLSG.K...NMLKDFLKEH.........
A0A0P7V514_9TELE/437-456             ............s--..--------TARQTLKE.K...GLWKEFRKRH.........
H2MSN2_ORYLA/15-43                   .............LL..RVPLRRNPTIRTQMRA.E...GLLDQFLKD-n........
F7HNZ5_CALJA/21-50                   .............LV..RIPLHKFTSIRRTMSEmG...GPVEDLIAK-g........
E2R9E5_CANLF/19-47                   .............VT..RVPLHKGKSLRKALKE.H...GLLEDFLKKH.........
I3KNQ1_ORENI/17-45                   .............LV..SIPLRRTRSIRTRLRA.D...GLLNEFLKDH.........
L5MFU3_MYODS/21-49                   .............LH..RVPLRRRQSLRKKLRA.R...GQLSEFWKSQ.........
H9G9A1_ANOCA/17-45                   .............LI..RIPLVRFNSIRGTLRK.K...GELDQFWRDH.........
W4WY81_ATTCE/26-56                   ........lyval--..RIPLHKTDSIRKTLKEvN...TDLTQFR---m........
F4WNQ0_ACREC/14-46                   ......lieaefq--..RIPLHKTDSIRKALKEvG...TDLTQVR---t........
H3C9K9_TETNG/19-48                   .............LV..RIPLNKFRSIRRELTDsG...RQVEELLAD-r........
A0A0K0JWL1_BRUMA/30-57               ............f-T..RIPLRKQNSLRKHLIE.T...DSWEAYS---kl.......
L9KR36_TUPCH/19-47                   .............IT..RIPLHKGKSLRRALKE.Q...GLLEDFLKTQ.........
PAG2_PIG/16-44                       .............LV..MIPLTKVKSVRESLRE.K...GLLKNFLKEH.........
E2RJN2_CANLF/21-49                   .............LH..RVPLRRHQSLRKKLRA.R...GQLSEFWKSQ.........
A0A087XHQ9_POEFO/21-49               .............VV..RVPLYKTRSLRRLMSDnG...RTVEELRA--l........
G1U3N9_RABIT/18-46                   .............IH..KVPLVRKKSLRKNLIE.K...GLLQDYLKTH.........
R4GL36_CHICK/17-44                   .............LV..RIKLKKGKSIREKMRE.A...GVLDEYLKK-.........
Q7K485_DROME/27-56                   .............LL..RVPLHKFQSARRHFADvG...TELQQLR---iry......
L9KTD9_TUPCH/18-46                   .............VV..KVSLKKGKSIRDTMKE.K...GLLKEFLRTH.........
G3U597_LOXAF/20-49                   ..........fcp--..RVPLFRKKSLRRNLKE.H...GLLDDFLKTH.........
B4MPC4_DROWI/24-53                   .............LL..RVPLKKFQSARRHFADvG...TELQQLRIKY.........
H2U4L2_TAKRU/19-48                   .............LV..RIPLKKFRSIRRELTDsG...RKIEELLAD-r........
W5NVC7_SHEEP/32-60                   .............IV..KIPLRRVKTVRKTLSE.K...NMLNNFLKEH.........
A0A087X773_POEFO/19-48               .............LV..RIPLKKFRSIRRELTDsG...KRAEELLAD-r........
L9LAI8_TUPCH/21-49                   .............LI..RIPLHKFPSIRRTLTEmG...GPVENLI---ah.......
W5L0D2_ASTMX/20-40                   ............l-Q..RVSLKKMPSIRETLKE.T...G---------v........
B4GDK1_DROPE/23-52                   .............LL..RVPLNRFQSARRHFADvG...TELQQLR---iry......
F1PE75_CANLF/17-45                   ............v-E..RIILKKGKSIRQVMEE.R...GVLETFLRNH.........
G1NPE0_MELGA/17-45                   ............l-Q..RVPLVRFKSIKTQLKE.K...GELEEFWRNH.........
K7J796_NASVI/19-48                   ............v-L..RVPLYRVKSARRTLQEvG...TELHQI----klry.....
F7C9L7_MONDO/19-47                   .............II..KVPLKRFKSMKQVMKE.K...GVWQDFQKSH.........
RENI2_MOUSE/28-48                    ............f-E..RIPLKKMPSVREILEE.R...GV--------.........
A0A087Y1P3_POEFO/17-45               .............MV..RVALMRVPSIRSQLRT.Q...GLLEDFLKDH.........
F6THW3_MACMU/31-51                   ...........fk--..RIFLKRMPSIRESLKE.R...GV--------.........
W5PPL1_SHEEP/17-45                   .............IV..IIPLMKMSTMQKTLKG.K...NLMNSFLEEH.........
H0XEM4_OTOGA/17-45                   .............IY..KVPLVRKKSLRQSLAE.N...GLLKDFLKNH.........
G1TKZ8_RABIT/18-46                   .............IH..KVPLVRKKSLRKNLIE.K...GLLKDYLKTH.........
A0A0D9RPN0_CHLSB/31-51               ...........fk--..RIFLKRMPSIRESLKE.R...GV--------.........
G1L5H8_AILME/26-55                   ............v-L..RIPLHKFTSIRRTMSElG...GPVEDLIAK-g........
G3N7P3_GASAC/17-45                   .............II..RIPLMRGKSARQALEE.R...GLFEEYRRK-f........
G3WIA3_SARHA/17-45                   ........lvrqi--..---LRKGKSIRELMEE.K...GVFEDFLRK-n........
G1RVK2_NOMLE/31-51                   ...........fk--..RIFLKRMPSIRESLKE.R...GV--------.........
A4IFS5_BOVIN/16-44                   .............IV..KIPLRRVNTMRKILSE.K...NMLNNFLKE-r........
G3N0B4_BOVIN/32-60                   .............IV..KIPLRRVKTMRNTVSG.K...NMLDNFLKEH.........
W5P828_SHEEP/16-46                   .............IVnkRIPLRRVKTMRKTLSG.K...HMLNNFLKEH.........
G3TA26_LOXAF/17-45                   ............f-Y..KVPLFRKKSLRRNLKE.H...GLLDDFLKTH.........
PEPA_MACMU/16-45                     ............iIY..KVPLVRKKSLRRNLSE.H...GLLKDFLKKH.........
S9YQF9_9CETA/16-45                   ...........it-H..KVPLVKKKSLRKNLTE.Q...GKLKDFLK--ih.......
F7BW04_ORNAN/17-45                   ............l-Q..RIPLVKFKSIRSHLRE.N...GALEEFLRDH.........
L5JXS5_PTEAL/21-49                   .............LH..RVPLRKYQSLRKKLRA.Q...GQLSEFWKSQ.........
E3NSK7_CAERE/18-46                   .............VV..QIPLMKIEPYRNRLIR.E...GRWVEYRKE-r........
M3YPZ3_MUSPF/18-46                   .............VI..KVPLRKLEPVRATMKE.K...GLLGEFLRTH.........
F8WD96_HUMAN/21-50                   .............LV..RIPLHKFTSIRRTMSEvG...GSVEDLIAK-g........
W5LMA9_ASTMX/19-48                   .............IV..RIPLKKFRSIRRSMTDsG...RAMEELLAD-s........
G3NZN2_GASAC/27-54                   ...........le--..-VPLHKTRSLRRVMSDnG...MSLEELRA--l........
G3U1Z4_LOXAF/9-36                    .............-H..RIPLHKFPSIRRTLSEaG...GSVENL----isk......
PEPA5_HUMAN/17-45                    .............MY..KVPLIRKKSLRRTLSE.R...GLLKDFLKKH.........
F1RIE6_PIG/16-44                     .............LV..MIPLTKVKSIRENLRE.K...GLLKNFLKEH.........
G3UNI4_LOXAF/20-45                   .............--..-VPLFRKKSLRRNLKE.H...GLLDDFLKTH.........
W5N1C1_LEPOC/18-46                   .............MH..KISLIKGKTAREALEE.R...GLWEEYRKRH.........
F7GKP1_MONDO/17-45                   .............IL..RIPLKKGKSIRETMKE.K...GVLEEFLKTY.........
D2I0K6_AILME/17-45                   .............II..KVPLVKKKSLRKNLKE.H...GLLKDFLKNH.........
W5P3R9_SHEEP/16-44                   .............IV..KVPLRRLKTMRKTLSG.N...NMLNNVLKEY.........
H0XCT4_OTOGA/15-47                   eavvinkflakre--..-------KSIRESMKE.K...GVLEEFLRT-n........
F7IPN1_CALJA/21-49                   .............LH..RVPLRKHPSLKKRLRA.R...SQLSEFLKSQ.........
I3KL05_ORENI/24-52                   .............LR..RIALKKMPSIRETLQElG...VSVEQVMT--e........
W5PNT1_SHEEP/21-49                   .............IV..KIPLRRVKTMRKTLSE.K...NMLNNFLKEH.........
F1RIE7_PIG/16-44                     .............LV..MIPLTKVKSVRESLRE.K...GLLKNFLREH.........
I3MWS9_ICTTR/1-27                    .............--..RVPLRKMKTMRQTMRE.K...GLLGDFLRTH.........
G3TIB5_LOXAF/19-46                   .............-V..KIPLKKMKSIRETMKD.K...GLLEEFLRTH.........
M0QVZ0_BOVIN/16-44                   .............IV..IMPLTKTKTMREILRE.K...NLLNSFLEEQ.........
PAG1_BOVIN/16-44                     .............IV..KIPLRRLKTMRNVVSG.K...NMLNNFLKEH.........
J9NYW4_CANLF/16-44                   .............LV..TIPLTRIKSMRENLRE.K...DKLKDYLEKH.........
I3M846_ICTTR/20-48                   .............IV..KVPLRKMKTMRQTMRE.K...GLLGDFLRTH.........
G1T1U4_RABIT/17-45                   .............IH..KVPLVRKKSLRKNLIE.K...GLLQDYLKTH.........
W5NSL3_SHEEP/16-44                   .............IV..IIPLTKVKTMRKTLSE.K...SMLKNFLKEH.........
F7H7Y3_MACMU/21-50                   .............LV..RIPLHKFTSIRRTMSEmG...GPVEDLIAK-g........
W5NVC2_SHEEP/32-60                   .............IV..KIPLRRVKTVRKTLSE.K...NMLNNFLKEH.........
M0QW24_BOVIN/16-44                   .............IV..KIPLRRVKTMRNTVSG.K...NILNNILKEH.........
G1KB82_ANOCA/17-45                   .............LV..TVPLKKGKSIRETMIE.K...GVLEDYLKHH.........
F1RUW7_PIG/18-46                     .............VI..KVPLKKLKSIRQAMKE.K...GLLEEFLKTH.........
F8W366_DANRE/19-45                   .............IV..RIPLKKFRTLRRTLSDsG...RSLEEL----v........
W5PJC0_SHEEP/13-41                   .............IV..KIPLRRMKTMRNTVSG.K...NMMNSFLKEH.........
H0XM18_OTOGA/16-44                   .............LV..RVPLMKVKSMRENLQE.N...GMLKEYLEKY.........
RENI_MACMU/31-51                     ...........fk--..RIFLKRMPSIRESLKE.R...GV--------.........
G1TM78_RABIT/17-45                   .............IH..KVPLVRKKSLRKNLIE.K...GLLQDYLKTH.........
G1LYC3_AILME/19-47                   ...........is--..RVPLHKGKSLRKALKE.H...GLLEDFLKTH.........
C3YBT8_BRAFL/17-43                   .............LH..RIPLTKMKTLRRQLADvG...IIYD------qim......
H3B127_LATCH/17-45                   .............LI..SVPLKRCKSIRESLRE.Q...GLLEDYLKNH.........
M4A7P5_XIPMA/17-45                   .............MV..RVPLRRVPSIRAQLRT.Q...GLLENFLKDH.........
M3YJR7_MUSPF/33-51                   .............--..RIFLKKMPSIRESLKE.R...GV--------.........
F7EHV9_XENTR/17-47                   ..........lir-H..RVPLKRQKSIRKKLKE.K...GKLSHVWTQ-q........
F6UM82_HORSE/17-45                   .............IY..KVPLVRKKSLRQNLIE.H...GLLEDFLKKH.........
I3LSA4_PIG/19-47                     .............IT..RVPLRKGKSLRKELKE.R...GLLEDFLQKQ.........
M7BRZ9_CHEMY/97-122                  .............--..-VTLKKGKSMREVVKE.K...GVLEDFLKHH.........
F6Q1N6_HORSE/21-49                   .............LH..RVPLRRHPSLRKKLRA.R...GQLSEFWKSQ.........
W5P802_SHEEP/23-56                   ......fvqmlge--..RIPLRRVKTMRKTLSG.K...NMLNDVLREH.........
L8Y1V8_TUPCH/16-39                   .............--..---LIKKKSLRKTLIE.H...GLLEEYLKKH.........
G4VEV7_SCHMA/15-46                   .........vvrp--..RIPLHPLKSAQRTLIEfE...TSLEIVKK--vw.......
PEPA_CHICK/2-30                      .............IH..RVPLKKGKSLRKQLKD.H...GLLEDFLKKH.........
W5N1D9_LEPOC/18-46                   ...........mq--..KIPLIKGKSARQALEE.K...GLWEEYRKRH.........
G1KH55_ANOCA/22-47                   ...........fq--..RIPLKKMPSIRETLQKmG...IKVADF----.........
W5M2U4_LEPOC/19-47                   .............II..RIPLKKFRSIRRSLSDvG...KSVEEL----vad......
M3X9S4_FELCA/17-45                   ............v-E..RIILKKGKSIRQVMEE.Q...GVLQTFLKNH.........
H2N3Y9_PONAB/21-49                   .............LH..RVPLRRHPSLKKKLRA.R...SQLSEFWKSH.........
G3N087_BOVIN/16-43                   ..........ivv--..-IPLTKVKIMRKTLT-.K...NLLNNFLKE-r........
G3X6K7_BOVIN/14-41                   .............-V..IIPLRKVKTMRNTFSE.K...KMLNNFLKEH.........
G3SFP5_GORGO/17-46                   ............iLC..RIILRKGKSIHQRMEE.Q...GVLETFLRDH.........
G3PYU1_GASAC/21-50                   .............MV..RIPLKKFRSIRRELSDsG...KTVEELKAE-k........
RENI_HUMAN/31-51                     ...........fk--..RIFLKRMPSIRESLKE.R...GV--------.........
#=GR RENI_HUMAN/31-51          SS    ...........SE--..EEEEEE---HHHHHHH.H...T---------.........
I3J2U1_ORENI/18-46                   .............LH..KMPLIKGKSARQTLKE.K...GLWEEYRKTH.........
G3N7P1_GASAC/18-46                   .............II..RIPLMRGKSARQALEE.R...GLFEEYRRK-f........
PEPC_CALJA/18-46                     .............VV..KVPLKKFKSIRETMKE.K...GLLWEFLKTH.........
A0A091DVL5_FUKDA/19-46               ............l--..KIPLKKFKSIRETMRE.K...GLLDDFLKTH.........
Q9TTV6_BOVIN/16-44                   .............IV..KIPLRRVKTMRKTLSG.K...NILNNFLKEH.........
H2U4L5_TAKRU/9-37                    ............f--..RIPLKKFRSIRRELTDsG...RKIEELLAD-r........
PEPE_CHICK/17-45                     .............IT..RLPLERGKKLREILRE.K...GLLHHFLQHH.........
H0WD90_CAVPO/16-40                   .............LV..TVPLMRVKSLRQSLRE.K...DLLEQY----.........
W5P5C6_SHEEP/32-60                   .............IV..KIPLRRVKTMRNTLSG.K...KMLNSFLKEH.........
M7B1R5_CHEMY/19-43                   .............LI..RIPLTKFPSVRRILNE.A...G---------seipd....
H0XZU2_OTOGA/21-48                   .............LH..RVPLTRYPSLRKKLQE.P...DQLSEFCK--s........
F7BKI2_HORSE/4-22                    .............--..RIFLRKMPSVRESLRE.R...GV--------.........
W5PHJ7_SHEEP/16-44                   .............IV..KIPLRRVKTMRKTLSE.K...NMLNNFPKEH.........
PAG1_PIG/16-44                       .............LV..IIPLTKVKSIRENLRE.K...DLLLNFLKEH.........
U3IPM0_ANAPL/39-67                   .............LL..RIPLKKGKSIREAMKE.K...GVLHEYLQQH.........
PEPA2_RABIT/16-45                    ............iVH..KVPLVRKKSLRKNLIE.K...GLLQDYLKTH.........
A0A0P7TZ83_9TELE/12-32               .............LR..RISLKKMPSIRQTLQE.-...----------mgv......
G3I107_CRIGR/18-46                   .............LV..RVPLKKMKTIRQNMKE.K...GVLKDFLKTH.........
G7NVC0_MACFA/21-49                   .............LH..RVPLRRHPSLKKKLRA.R...SQLSEFWKSQ.........
B4J475_DROGR/20-49                   .............LY..RVPLHRFPSVRHRFQQfG...IRMDRLRLKY.........
U3K6K6_FICAL/14-45                   .........ivav-E..RIPLIRFKSIKKQLKE.K...GELEEFWRNH.........
Q3UCD9_MOUSE/21-50                   .............II..RIPLRKFTSIRRTMTEvG...GSVEDLI---lkg......
A0A0J7KWJ8_LASNI/19-46               .............IH..RIPLHKTDSIRKALKEvD...TDLQQVR---l........
W5NX00_SHEEP/19-47                   .............LV..KIPLKKFKSIRETMKE.K...GLLEDFLRTY.........
F1NLA4_CHICK/30-55                   ............l-Q..RIALRRMPSIRQTLQEmG...VKVSD-----v........
F7E8K7_MACMU/21-49                   .............LH..RVPLRRHPSLKKKLRA.R...SQLSEFWKSQ.........
A0A0K0F109_9BILA/3-25                ............e--..-----RVKSVRRRLIR.E...GKLEEFLKE-l........
U3IY42_ANAPL/31-55                   ............l--..RIALRRMPSIRQTLQEmG...VKV-------adv......
G7P3W6_MACFA/18-46                   .............VV..KVPLKKFKSIRETMKE.K...GLLGEFLRTH.........
PAG6_SHEEP/16-44                     .............IV..KIPLRRVKTMRKTLSE.K...NMLNNFLKEH.........
W5P817_SHEEP/16-44                   .............IV..KIPLRRVKIMRNTLRG.K...NMLNNFLKEH.........
A8MN26_PAPAN/18-46                   .............VV..KVPLKKFKSIRETMKE.K...GLLGEFLRTH.........
V4A9Z7_LOTGI/19-43                   .............LI..RLPLHKFKTVRRTLKD.-...----------lhisidk..
W5PEJ9_SHEEP/32-60                   .............IV..KIPLRRVKTMRKTLSG.K...HMLNNFLKEH.........
F7BVZ5_ORNAN/17-45                   ............l-Q..RIPLVKFKSIRSHLRE.N...GALEEFLRDH.........
W5PCY6_SHEEP/16-46                   ............i-VneRIPLRRVETMRNTFSA.K...NMLNNLLKEH.........
W5NQB5_SHEEP/13-41                   .............IV..ILPLRKMKTLRETLRE.K...TLLNNFLEEH.........
H3CB13_TETNG/1-27                    .............--..RVPLRRMPSIRSRLRA.L...GLLPHYLKEH.........
G1M378_AILME/18-46                   .............VV..KVPLRKLESIRETMKD.K...GLLGEFLRTH.........
H0XTD3_OTOGA/21-49                   .............LV..RVPLMKVKSMRENLEE.N...GMLKQYLEKY.........
F6THX9_MACMU/31-51                   ...........fk--..RIFLKRMPSIRESLKE.R...GV--------.........
H2MSN1_ORYLA/18-46                   .............LL..RVPLRRNPTIRTQMRA.E...GLLDQFLKD-n........
H3DKM3_TETNG/24-52                   .............LR..RITLKKMPSIRESLGEmG...VSVEQVLTE-.........
F1MSC1_BOVIN/14-42                   .............IV..IIPLMKMSTMQKTLKG.K...NLMNSFLEEH.........
F6U1X6_HORSE/14-42                   .............IY..KVPLVKKKSLRQNLRE.N...GLLADFLKQH.........
H2PJ08_PONAB/18-46                   .............VV..KVPLKKFKSIRETMKE.K...GLLGEFLRTH.........
G1SUX4_RABIT/16-45                   ............iVH..KVPLVRKKSLRKNLIE.K...GLLQDYLKTH.........
U3IRI2_ANAPL/21-48                   .............LC..RIQLRKYKSARELMRE.A...GVLKDYLKK-.........
F7E8K2_MACMU/21-49                   .............LH..RVPLRRHPSLKKKLRA.R...SQLSEFWKSQ.........
A0A0D9R1V6_CHLSB/17-45               .............IH..KVPLVRKKSLRRNLSE.H...GLLKDFLKKH.........
G3QPX2_GORGO/21-50                   .............LV..RIPLHKFTSIRRTMSEvG...GSVEDLIAK-g........
E2BND1_HARSA/9-37                    .............LL..RIQLHKTESIRRILQEvG...TDLHQVR---ly.......
W5NQX3_SHEEP/16-44                   .............IV..IIPLTKMKTMGEILSE.N...NLLNIFMKEH.........
A7MBA4_BOVIN/16-44                   .............IV..KIPLRQVKTMRKTLSG.K...NTLNNFLKEH.........
A0A096N8P1_PAPAN/58-78               ...........fk--..RIFLKRMPSIRESLKE.R...GV--------.........
M3WL88_FELCA/18-45                   .............VV..KVPLSKRESIWETMKE.K...GLLGEFLRT-.........
PAG1_SHEEP/16-44                     .............IV..KIPLRRVKTMRNTLSG.K...KMLNSFLKEH.........
W5PN47_SHEEP/16-44                   .............IV..KIPLRRVKTMRKILSG.K...NMMNNFLKEH.........
RENI_SHEEP/25-54                     ............f-R..RIFLKKMPSVRESLKE.R...GV--------dmaqlgaew
G3NZM7_GASAC/18-47                   ............lIC..RVPLHKTRSLRRVMSDnG...MSLEELRA--l........
T0MFU5_9CETA/25-45                   ............f-R..RIFLKKMPSVRESLKE.R...GV--------.........
U3J184_ANAPL/16-41                   .............--..-VTLTRHRSLRKTLRD.R...GQLSQFWKAH.........
U3J037_ANAPL/17-45                   ............m-E..RVPLIRFKSIKKQLKE.K...GELEEFWRDH.........
G3PFM2_GASAC/17-37                   .............IV..KIPLQKHKSMREALRD.K...GI--------.........
V8NB55_OPHHA/19-47                   .............LI..RIPLKKFPSMRSIYNEyG...TNIQDL----tel......
G5E637_BOVIN/16-44                   .............IV..KIPLRRVKTMRKTLSG.K...NMLNNFLKE-d........
I3NHK1_ICTTR/1-27                    .............--..RVPLRKMKTMRQTMRE.K...GLLRDFLRTH.........
G5C2G1_HETGA/3-30                    .............--..RIPLHKFKSIRRTMTEvG...GSVEDLIA--hg.......
F6ZBR1_XENTR/23-52                   ............lIY..RVPLRKGESFRNRLQR.L...GLLGDYLKKY.........
F1PIV2_CANLF/17-45                   .............IV..KIPLVRKKSLRQKLIE.H...GLLNDFLKNQ.........
H2ZA35_CIOSA/2-22                    ............q-V..RIKLHKQKTLRQIMKE.K...G---------t........
G1N0R4_MELGA/18-46                   .............IH..RIPLQKGKSLRKQLKE.H...GLLEDFLKKH.........
F7I3G2_CALJA/31-51                   ...........fk--..RISLKRMPSIRESLKE.R...GV--------.........
D3YZ92_MOUSE/18-46                   .............LI..RVPLKKMKSIRETMKE.Q...GVLKDFLKNH.........
G1MU15_MELGA/17-46                   ..........its--..RLPLDRGKKLREILRE.K...GLLHRFLQHH.........
F7GR22_CALJA/18-46                   ...........vp--..RIPLHKGKSLRRALKE.R...GLLEDFLKNH.........
G3U980_LOXAF/12-40                   .............LL..RVHLHKGKSMRQALKE.S...GLLDDFLRKH.........
G1QYB3_NOMLE/25-45                   .............--..------FKSIRETMKE.K...GLLGEFLRTH.........
W5PG91_SHEEP/16-43                   .............IV..IILLRKVKTMRNTFS-.K...KMLNNFLK--gh.......
G3SCD8_GORGO/31-51                   ...........fk--..RIFLKRMPSIRESLKE.R...GV--------.........
G1TUA3_RABIT/21-49                   .............II..RIPLHKFTSIRRTMSEaW...GPVEDL----iar......
I3KEQ5_ORENI/19-43                   .............LV..RIPLKKFRSIRRELTD.S...G---------kgiee....
A0A0D9RFU6_CHLSB/18-46               .............VV..KVPLKKFKSIRETMKE.K...GLLGEFLRTH.........
L9JAZ5_TUPCH/25-45                   ...........fq--..RIFLKKMPSVRESLKE.R...G---------a........
S9Z0C4_9CETA/79-106                  ............g--..RIPLTKVKPMRENLRE.K...NMLKDFLEQY.........
H2V474_TAKRU/18-46                   .............LV..KVPLTRGKTARQILEE.Q...GLWEEYKQ--nn.......
F1P784_CANLF/17-45                   ............v-E..RIILKKGKSIRQVMEE.R...GVLETFLRNH.........
PEPA_BOVIN/3-31                      .............VV..KIPLVKKKSLRQNLIE.N...GKLKEFMRTH.........
C3Y5F5_BRAFL/17-45                   .............LH..RIPLTKVKTVRRQLADvG...ITYDQIL---dk.......
I3LL61_PIG/16-44                     .............LV..TIPLRKVKSIRENLRD.K...GLLKNFLGEH.........
F7ADP0_XENTR/15-35                   .............II..KVPLKRFKSMREVMRE.H...GI--------.........
F6Z2Y5_XENTR/22-42                   .............LV..RIPLKKFTSIRRAMSE.-...----------tdq......
F6YRX8_XENTR/16-45                   ..........lyf--..RVPLMKSKSIRQNMAE.A...GVLDKYLQTH.........
A0A087Y4E0_POEFO/24-53               .............LR..RIALKKMPSIRETLQEmG...VSAEQVLAE-l........
PEPB_CANLF/17-45                     ............v-E..RIILKKGKSIRQVMEE.R...GVLETFLRNH.........
G1U4T7_RABIT/17-45                   .............IH..KVPLVRKKSLRKNLIE.K...GLLKDYLKTH.........
F1RID0_PIG/16-44                     .............LV..IIPLTKVKSIRENLRE.K...DLLLNFLKEH.........
I3KL06_ORENI/30-57                   ............f--..RIALKKMPSIRETLQElG...VSVEQVMT--e........
F7GPP3_MACMU/26-54                   .............LL..RVPLHKGKSLRRTLKE.H...GLLEDFLRNH.........
G1PKG7_MYOLU/17-45                   ............v-E..RIILKKGKSIRQTMEE.K...GVLEKFLKNH.........
G1RSC1_NOMLE/21-50                   .............LV..RIPLHKFTSIRRTMSEvG...GSVEDLIAK-g........
H0XNA3_OTOGA/16-43                   .............LV..RVPLIKVKSMRENLQE.N...GMLKEYLEK-.........
CATD_BOVIN/1-28                      .............VI..RIPLHKFTSIRRTMSEaA...G---------xvxxlia..
W5PGM4_SHEEP/9-37                    .............IV..KMPLRRVKTMRKNPSG.K...NMMNNFLKEH.........
H0XQS9_OTOGA/16-44                   .............LV..RVPLMKVKSMRENLQE.N...GMLKEYLEKY.........
PEPC_MONDO/19-45                     .........vrqi--..---LHKGKSIRERMEE.N...GVLEDFLR--y........
G3I684_CRIGR/18-47                   ..........vat--..RIPLHKGTSLRNTLKE.H...GLLEDFLSRH.........
B4MQ73_DROWI/30-59                   .............LY..RVPLHRFPSARRRFEQfG...IRMERLRL--ry.......
W5PR36_SHEEP/53-81                   ...........vf--..KIPLVKKKSLRQNLIE.N...GKLKEFMKTH.........
H0Y0G3_OTOGA/16-43                   .............LV..RVPLMKVKSMRENLQE.N...GMLKEYLEK-.........
F6YJP9_HORSE/19-45                   ............n--..-VPLVKRKSLRQNLRE.N...GLLEDFLKQH.........
W5NZB3_SHEEP/16-44                   .............IV..KIPLRRVKTMRKTLSG.K...NMLNDVLMEH.........
G3UDK2_LOXAF/16-44                   .............LI..MIPLQKIQPLREKLRE.K...DLLRDFLET-d........
M7B5P0_CHEMY/17-45                   ............l-Q..RVPLRRHKSLRKILRE.H...GQLSKFWKDQ.........
F7D2K8_MACMU/16-45                   ............iIY..KVPLVRKKSLRRNLSE.H...GLLKDFLKKH.........
F1ND20_CHICK/30-58                   ...........lk--..RVTLTRHRSLRKSLRD.R...GQLSQFWKAH.........
PEPB_PIG/1-29                        ............m-E..RIILRKGKSIREAMEE.Q...GVLEKFLKN-r........
A0A0R4IA33_DANRE/47-75               .............LL..RVALRQYPSVRSRLRA.S...AQLEEFLKQH.........
M0QW01_BOVIN/13-40                   ............t-V..RIPLRKVKTMRNIFS-.K...KMLNNFLKEH.........
E3N573_CAERE/18-46                   .............VV..QIPLMKIEPYRNRLIR.E...GRWVEYRKE-r........
A0A096MPA5_PAPAN/41-68               .............-H..RVPLVRKKSLRHNLSE.H...GLLKDFLKKH.........
G1N3F2_MELGA/31-59                   .............LL..RVPLKKGKSIREVMKE.S...GVLHDYLANH.........
G3X7I3_BOVIN/16-44                   .............VV..ILPLKKMKTLRETLRE.K...NLLNNFLEEQ.........
G3QEX5_GORGO/31-51                   ...........fk--..RIFLKRMPSIRESLKE.R...GV--------.........
W5PLS6_SHEEP/23-44                   .............--..-----KVKTMRKTFSG.K...NMLNNFLKEH.........
H0XKR9_OTOGA/23-51                   .............LC..RVILRKGKSIRQAMEE.Q...GVLEEYLKNH.........
U3KB35_FICAL/19-39                   .............LI..RIPLTKFPSMRRILRE.A...G---------s........
H2R5D9_PANTR/17-45                   .............MY..KVPLIRKKSLRRTLSE.R...GLLKDFLKKH.........
W5PB53_SHEEP/16-44                   .............IV..KIPLRRMKTMRKTLSG.K...NMLNNVLKEH.........
G1TWX2_RABIT/1-27                    .............--..RVPLRKFKSIRETLKE.K...GLLKEFLNTH.........
M7B1G1_CHEMY/17-45                   .............LV..RLTLKKGKTIREVMKE.K...GVLVDYLKHH.........
W5P4I2_SHEEP/3-34                    .........lrld--..RIPLQKFTSIRRTMSEaM...GPVEHLIA--kg.......
H0XM90_OTOGA/19-47                   .............IT..RIPLHKGKSLRTILGE.R...GLLDYFLREY.........
G3X7A6_BOVIN/16-43                   ..........ivv--..-IPLTKVKIMRKTLT-.K...NLLNNFLKE-r........
W5NRD7_SHEEP/17-45                   .............IV..EIPLMKVNVMQETLNE.K...SLLNNFLKKY.........
G7YV90_CLOSI/19-47                   .............VI..RIPLTGFKNVRRRLMEvG...TPVEQL----nft......
A0A0D9R201_CHLSB/17-45               .............IH..KVPLVRKKSLRRNLSE.H...GLLKDFLKKH.........
L9KR52_TUPCH/17-45                   ............v-E..RIILRRGKSIRQAMEE.Q...GVLETFLNS-y........
M3WZI5_FELCA/17-45                   ............v-E..RIILKKGKSIRQVMEE.R...GVLQTFLKNH.........
PAG_HORSE/16-44                      .............LV..TIPLVKIKSLRENLRE.K...DMLKEYLEKY.........
H3B1M9_LATCH/17-45                   .............IR..RVPIKRRQSMRKALRN.R...GTLSDFWKTH.........
F1N1P6_BOVIN/16-44                   .............IV..KIPLRRVKTMRKTLSG.K...NMLNNFLKEH.........
F6V731_HORSE/17-45                   .............IY..KVPLVKKKSLRQNLRE.N...GLLEDFLKQH.........
F7I151_CALJA/18-46                   .............VV..KVPLKKFKSIRETMKE.K...GLLWEFLKTH.........
G4VEV6_SCHMA/15-44                   .............VV..RIPLHPLKSAQRTLIEfE...TSLEIVKK--vw.......
H0XLY6_OTOGA/20-45                   .............--..-VPLMKVKSMRENLQE.N...GMLKEYLEKY.........
Q5BKJ1_XENTR/17-45                   .............LI..RVPLHKSKTIRETMKE.K...GVLKEFMKTH.........
H0Z9B1_TAEGU/1-27                    .............--..RIPLIRFKSIKKQLKE.K...GELEEFWRNH.........
A0A0N4UV42_ENTVE/22-47               ............v-L..RIPLKKQKTIREQLVE.T...NSWHEY----v........
F8WIR1_MOUSE/21-50                   .............II..RIPLRKFTSIRRTMTEvG...GSVEDLI---lkg......
G3RX21_GORGO/17-45                   .............MY..KVPLIRKKSLRRTLSE.R...GLLKDFLKKH.........
H3B4C1_LATCH/20-46                   .............II..RIPLRKFRTMRRTMSDgR...MSIEE-----lk.......
H2ND88_PONAB/17-45                   .............MY..KVPLIRKKSLRRTLSE.H...GLLKDFLKKH.........
E1BI12_BOVIN/12-44                   ..........yim--..KIPLRRVKTMRKTLTE.KkkkNILNNFLKKH.........
F6YAL3_CALJA/21-50                   .............LV..RIPLHKFTSIRRTMSEmG...GPVEDLIAK-g........
G3NZ44_GASAC/18-46                   .............LH..KIPLIKGKTARENLQE.K...GLWEQYRKQH.........
PAG2_BOVIN/16-44                     .............IV..ILPLKKMKTLRETLRE.K...NLLNNFLEEQ.........
G1QHW2_NOMLE/21-49                   .............LH..RVPLRRHPSLKKKLRA.R...SQLSEFWKSH.........
W5N4U3_LEPOC/17-38                   .............LV..RIPLKRFKSIREQMRE.S...GK--------y........
F6QSR1_CALJA/18-46                   .............VV..KVPLKKFKSIRETMKE.K...GLLWEFLKTH.........
PEPC_RABIT/18-46                     .............VI..KVPLRKFKSIRETLKE.K...GLLKEFLNTH.........
M3ZG39_XIPMA/21-49                   .............VV..RVPLYKTRSLRRLMSDnG...RTVEELRA--l........
F6QFQ9_XENTR/17-37                   .............II..KVPLKRFKSMREVMRE.H...GI--------.........
H0ZGM2_TAEGU/19-39                   .............LI..RIPLTKFPSMRRILKE.A...G---------s........
W5N1A5_LEPOC/17-45                   .............MT..KVPLLKRKSMRKALME.Q...GKLEEFLQKY.........
M3WJA1_FELCA/17-45                   .............II..KVPLIKKKTLRENLIE.H...GLLDDFLKKY.........
F7EFI4_XENTR/17-45                   .............LV..RVPLKRYKSARDIMRE.R...GILKEFMKTH.........
G3WWG2_SARHA/24-49                   ............l--..--PLKRHKSLRKTLRE.R...GQLSQFWETH.........
F1MPA5_BOVIN/16-44                   .............IV..KIPLRRVKTMRKTLSG.K...NMLNNFLKE-d........
F7D2M9_MACMU/17-45                   .............IH..KVPLIRKKSLRRNLSE.H...GLLKDFLKKH.........
PEPA3_HUMAN/17-45                    .............MY..KVPLIRKKSLRRTLSE.R...GLLKDFLKKH.........
W5QC55_SHEEP/16-44                   .............IV..KIPLGRMKTMRNALSG.R...NMLKNFLKE-r........
M0QW02_BOVIN/24-45                   .............--..-----KLKTMRKTLSG.K...NMLNNFLKEH.........
E2R015_CANLF/16-44                   .............LV..TIPLTRIKSMRENLRE.K...DKLKDYLEKH.........
R0JA02_ANAPL/17-45                   ...........ft--..KLPLERGKKLREILRE.K...GLLRHFFQRH.........
G7PNW0_MACFA/58-88                   ............l-V.dRIPLHKFTSIRRTMSEmG...GPVEDLIAK-g........
W5P4H9_SHEEP/3-34                    .........lrld--..RIPLQKFTSIRRTMSEaM...GPVEHLIA--kg.......
G1QCB2_MYOLU/37-65                   .............LV..TIPLTKIKSMRESLRE.R...DLLRDYLQRH.........
F7FND8_CALJA/21-49                   .............LH..RVPLRKHPSLKKRLRA.R...SQLSEFLKSQ.........
A0A096M124_POEFO/19-48               .............LV..RIPLKKFRSIRRELTDsG...KRAEELLAD-r........
A0A0P7UGV0_9TELE/2-20                .............--..KVPLTKTKSIRERLLE.K...GV--------.........
H9HA44_NOMLE/8-36                    .............MY..KVPLIRKKSLRRTLSE.H...GLLKDFLKKH.........
CHYM_BOVIN/19-47                     .............IT..RIPLYKGKSLRKALKE.H...GLLEDFLQKQ.........
G1STG9_RABIT/20-48                   .............LV..TIPLMKVKSMRENLRE.N...DILLDYLEKH.........
CATE_RABIT/21-49                     ...........ld--..RVPLRRQPSLRKKLRA.Q...GQLSEFWKAH.........
RENI1_MOUSE/29-49                    ............f-E..RIPLKKMPSVREILEE.R...GV--------.........
U3JKI2_FICAL/18-45                   .............LC..RISLKKGLSIRDKMRT.A...GVLDDFLKH-.........
PEPA4_RABIT/16-45                    ............iVH..KVPLVRKKSLRKNLIE.K...GLLQDYLKTH.........
A0A0D9RQT6_CHLSB/21-49               .............LH..RVPLRRHPSLKKKLRA.R...SQLSEFWKSQ.........
M3X9F0_FELCA/16-44                   .............LV..TIPLTRVKSMRENLRE.K...DRLKDFLENH.........
F1RIE4_PIG/32-60                     .............LV..MIPLTKVKSVRESLRE.K...GLLKNFLKEH.........
G3VHT8_SARHA/17-48                   ........miscg--..RLPLMKGNTLRHKLKK.H...GLLADFLEE-n........
H0XYL6_OTOGA/16-44                   .............LV..RVPLMKVKSMRENLQE.N...GMLKEYLEKY.........
M3W6E6_FELCA/22-50                   .............LH..RVPLRRHPSLRKKLRA.R...GQLPEFWKSQ.........
CHYM_CALJA/19-47                     .............IV..RIPLHKGKSLRRALKE.R...GLLEDFLKNH.........
D3Z6T3_MOUSE/22-50                   .............LH..RVPLRRHQSLRKKLRA.Q...GQLSEFWRSH.........
PEPC_RAT/18-46                       .............LL..RVPLRKMKSIRETMKE.Q...GVLKDFLKTH.........
PEPA1_RABIT/16-45                    ............iVH..KVPLVRKKSLRKNLIE.K...GLLQDYLKTH.........
E1C897_CHICK/15-45                   ..........val-Q..RVSLVRFKSIKTQLKE.K...GELEEFWRNH.........
G1RVK3_NOMLE/31-51                   ...........fk--..RIFLKRMPSIRESLKE.R...GV--------.........
Q9PWK1_CHICK/17-45                   .............IL..RVPLKKGKSIREAMKE.S...GVLHDYLANH.........
M3YSB2_MUSPF/16-44                   .............LV..TIPLTRVKSMRENLRE.K...DKLRDYLEKH.........
W5LKM0_ASTMX/19-47                   .............II..KVPLIKGKSARESLEE.K...GMWEQYRKLY.........
G3QJP9_GORGO/18-46                   .............VV..KVPLKKFKSIRETMKE.K...GLLGEFLRTH.........
H2R879_PANTR/31-51                   ...........fk--..RIFLKRMPSIRESLKE.R...GV--------.........
V8NMF0_OPHHA/1-26                    .............--..-IPLVQFNSIQTVLRK.G...GQLEQFWRN-n........
F1MYF7_BOVIN/16-44                   .............IV..IIPLTKVKTMRKTLSE.K...NMLSNFLKEH.........
A0A091CNN8_FUKDA/22-50               .............IH..RVPLKRRESLRKKLQA.Q...GQLTDFWKSQ.........
H0XYE6_OTOGA/17-45                   .............IY..KVPLVRKKSLRQSLAE.N...GLLKDFLKNH.........
F1MMR6_BOVIN/23-52                   .............VI..RIPLHKFTSIRRTMSEaM...GPVEHLIA--kg.......
W5N2H9_LEPOC/19-39                   .............LI..RISLKKMPSIRETLREmG...----------v........
W5P4R3_SHEEP/16-44                   .............IV..KIPLRRVKTMRNTVSG.K...NMLNNFLKEH.........
S9WB58_9CETA/19-47                   .............IT..RIPLHKGKTLRKALKE.R...GLLEDFLQR-q........
M0QW19_BOVIN/32-60                   .............IV..KIPLRRVKTMRKTLSG.K...NMLNNFLKEH.........
F1N7M7_BOVIN/16-44                   .............IV..KIPLRRVKTMRKALSG.K...NMLNNFLKEH.........
CATE_RAT/23-51                       .............LH..RVPLRRHQSLRKKLRA.Q...GQLSDFWRSH.........
PEPAF_RABIT/16-44                    .............LV..TIPLMKVKSMRENLRE.N...DILLDYLEKH.........
G3NZL5_GASAC/21-49                   .............II..RVPLHKTRSLRRVMSDnG...MSLEELRA--l........
H9GPN8_ANOCA/17-46                   ...........lv-T..KVPLKKTKSLRQNLKE.H...GLLEKYLQKH.........
PEPA_CANLF/17-45                     .............IV..KVPLVRKKSLRQNLIE.H...GLLNDFLKNQ.........
G1QCR9_MYOLU/16-43                   .............LV..TVPLTKIKSMRE-LRE.R...DLLRDYLQRH.........
G5E7U3_MELGA/17-45                   .............IH..RIPLQKGKSLRKQLKE.H...GLLEDFLKKH.........
I3MSA9_ICTTR/5-32                    ............p--..RVPLRKMKTMRQTMRE.K...GLLRDFLRTH.........
G3W996_SARHA/18-46                   ............f-R..RIPLKKGKSIRDTMKE.K...GVLEDFLKTH.........
H2Q3T7_PANTR/17-45                   .............MY..KVPLIRKKSLRRTLSE.R...GLLKDFLKKH.........
M7BRZ9_CHEMY/551-576                 .............--..-VTLKKGKSMREVVKE.K...GVLEDFLKHH.........
M7B5Q8_CHEMY/951-976                 ...........fq--..RIPLKKMPSIRQSLQEmG...VKVSD-----v........
G3I4W7_CRIGR/21-50                   .............VI..RIPLRKFTSIRRTMTEvG...GSVEDLI---lkg......
F7FJM0_MONDO/19-45                   .........vrqi--..---LHKGKSIRERMEE.N...GVLEDFLR--y........
H3CE79_TETNG/22-51                   .............LV..RIPLNKFRSIRRELTDsG...RQVEELLAD-r........
CATD_MOUSE/21-50                     .............II..RIPLRKFTSIRRTMTEvG...GSVEDLI---lkg......
I3MRV6_ICTTR/21-44                   .............LI..RIPLYKFTSIRRTMTEaG...GPVE------.........
G1LGC9_AILME/17-45                   ............v-E..RIVLKKGKSIRQVMEE.R...GVLETFLKNH.........
F1MKK1_BOVIN/16-44                   .............IV..ILPLRKMKTLRETLRE.K...NLLNNFLEE-r........
F1P448_CHICK/17-45                   .............IH..RVPLKKGKSLRKQLKD.H...GLLEDFLKKH.........
L5LZA1_MYODS/17-45                   ............v-E..RIILKKGKSIRQTMEE.K...GVLEKFLKNH.........
I3NG57_ICTTR/16-44                   .............LV..TIPLMKIKSMRENLQE.N...NVLDDYLEKY.........
W5NWT5_SHEEP/16-44                   .............IV..KIPLRRVKTMSNTASG.K...NMLNNFLKKH.........
F1RIE5_PIG/16-44                     .............LV..MIPLTKVKSVRESLRE.K...GLLKNFLREH.........
A0A0P7UMY5_9TELE/19-46               .............LV..RIPLQKFRSIRHTLSDsG...RSIEELM---a........
H2ZZV4_LATCH/20-43                   .............LI..RIPLKKFRSIRRTLTD.S...G---------rdie.....
G3PP46_GASAC/18-46                   .............II..RVPLKRVRSVRSQLRV.E...GLLEEFLKEH.........
G1Q3R0_MYOLU/37-65                   .............LV..TVPLMKIKSMRENLRE.R...DLLRDYLQRH.........
H3A5Z4_LATCH/17-45                   .............IF..RIPLARFRSIRMELTE.K...EELEEFLQDH.........
RENI_PANTR/31-51                     ...........fk--..RIFLKRMPSIRESLKE.R...GV--------.........
G1LM29_AILME/16-44                   .............LV..TIPLTRIKSIRENLRE.K...DRLKDYLEKH.........
PEPC_PIG/2-30                        .............VI..KVPLKKLKSIRQAMKE.K...GLLEEFLKTH.........
H2U4L3_TAKRU/21-47                   .............--..-IPLKKFRSIRRELTDsG...RKIEELLAD-r........
W5PC14_SHEEP/16-44                   .............IV..KIPLRRVKTMRKNLSG.K...NMLNNFLKKH.........
G3T8U8_LOXAF/21-49                   .............LH..RVPLRRHKSLRKKLRE.R...GQLSEFWKSQ.........
G5BNI3_HETGA/19-46                   ............l--..KIPLKKFKSIRETMRD.K...GLLGDFLKTH.........
F7IM82_CALJA/1-29                    .............LC..RIILRKGKFIRQTVEE.Q...GVLETFLRHH.........
C3YUT2_BRAFL/17-46                   .............LH..RIPLTKMKTVRRHLAEvG...VPYDKIIKD-y........
RENI_CALJA/31-51                     ...........fk--..RISLKRMPSIRESLKE.R...GV--------.........
F1QDA2_DANRE/21-45                   .............II..RIPLHKMRTVRRMLAD.N...G---------ktide....
H0XP70_OTOGA/16-44                   .............LV..RVPLIKVKSMREKLQE.N...GMLKEYLEKY.........
B7QNL3_IXOSC/19-39                   ............s--..-VPLHRFKSVRRALEEvG...TE--------v........
H2V473_TAKRU/20-47                   .............-V..RVPLTRGKTARQILEE.Q...GLWEEYKQ--nn.......
W5P7Z6_SHEEP/32-60                   .............IF..KIPLRRVKTMRKTLSG.K...NMLNDVLKEH.........
W5NXW2_SHEEP/32-60                   .............IV..KIPLRRVKTMRNTLSG.K...NMLNNLLKEH.........
F6SCQ4_CALJA/18-46                   .............VV..KVPLKKFKSIRETMKE.K...GLLWEFLKTH.........
M3XZ02_MUSPF/17-45                   ............v-E..RIILKKGKSIRQVMKE.R...GVLDTFLKNH.........
M3YS78_MUSPF/18-46                   .............IV..KVPLVRKKSLRKTLLD.H...GLLGDFLKKH.........
Q6P6T6_RAT/21-50                     .............LI..RIPLRKFTSIRRTMTEvG...GSVEDLI---lkg......
A0A096N3G8_PAPAN/21-49               .............LH..RVPLRRHPSLKKKLRA.R...SQLSELWKSQ.........
W5NZV1_SHEEP/16-46                   ............i-VdeRIPLKKVKTMRNTLSD.K...NMLSNFLKEH.........
U3JKE3_FICAL/18-46                   ............v-T..RLPLERGKKLRDVLRE.K...DLLHQFFQHH.........
E0VMS3_PEDHC/19-48                   .............LI..RVPLYKFQSARRTLRGvG...TDVEHLRMR-y........
W5PJD5_SHEEP/16-49                   ......ivkmlge--..RIPLRRVKTMRNTISG.K...NILNSFLKEH.........
L5K602_PTEAL/19-47                   .............IT..RVPLHKGKSLRKALKE.R...GLLEDFLRTH.........
O46497_BOVIN/16-44                   .............IV..KIPLRQVKTMRKTLSG.K...NMLKNFLKEH.........
CATE_HUMAN/21-49                     .............LH..RVPLRRHPSLKKKLRA.R...SQLSEFWKSH.........
#=GR CATE_HUMAN/21-49          SS    .............-E..EEE-BXXXXXXXXXXX.X...XXXXXXXXXX.........
A0A0R4IBQ0_DANRE/21-44               .............--..-IPLKKFRTLRRTLSDsG...RSLEEL----v........
M3ZC57_NOMLE/44-71                   .............-H..RVPLIRKKSLRRTLSE.H...GLLKDFLKKH.........
I3JPE6_ORENI/21-49                   .............IL..RVPLYKTRSLRRLMSDnG...MSVDEL----ral......
C9JH19_HUMAN/5-35                    ............v-V.dRIPLHKFTSIRRTMSEvG...GSVEDLIAK-g........
T1HPQ4_RHOPR/22-51                   .............LV..RVPLTKIQSARRTFQEvG...TSVKQL----siky.....
H9GJA6_ANOCA/21-49                   ...........ln--..RVPLKRHKSLRNILRE.R...GELSKFWKSY.........
CATD_RAT/21-50                       .............LI..RIPLRKFTSIRRTMTEvG...GSVEDLI---lkg......
I3N6E4_ICTTR/5-32                    ............p--..RVPLRKMKTMRQTMRE.K...GLLGDFLRTH.........
H2V472_TAKRU/21-48                   .............-V..RVPLTRGKTARQILEE.Q...GLWEEYKQ--nn.......
A0A0K0F107_9BILA/25-48               ............t--..----YRVESIRERLIR.E...GKLEDFLKE-i........
W5PP63_SHEEP/16-42                   .............IV..IIPLTKVKTMQKTLS-.L...KLLNSFLKE-.........
G3HAY9_CRIGR/21-49                   .............IH..RVPLRKHQSIRKKLRA.R...GKLSDFWKSQ.........
L5KQ85_PTEAL/17-45                   .............IY..KVPLVKKKSLRRNLIE.H...GLLADYLKTH.........
F7DUF2_HORSE/17-45                   .............IY..KVPLVKKKSLKKNLIE.N...GLLEDFLKQH.........
#=GC SS_cons                         ...........SE-E..EEEEEEXXXHHHHHHH.T...TXHHHHHCCX.........
#=GC seq_cons                        .............lh..+lPL+KhKSlRcsLpE.+...GhLpcalcp..........
//
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