GenomeNet

Database: Pfam
Entry: ABC_membrane_2
LinkDB: ABC_membrane_2
Original site: ABC_membrane_2 
#=GF ID   ABC_membrane_2
#=GF AC   PF06472.10
#=GF DE   ABC transporter transmembrane region 2
#=GF PI   Ald_N; 
#=GF AU   Yeats C
#=GF SE   ADDA_6479
#=GF GA   21.20 21.20;
#=GF TC   21.20 21.20;
#=GF NC   21.10 21.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Transmembrane_domain_of_ABC_transporters
#=GF RN   [1]
#=GF RM   1301993
#=GF RT   Mutations in the 70K peroxisomal membrane protein gene in
#=GF RT   Zellweger syndrome. 
#=GF RA   Gartner J, Moser H, Valle D; 
#=GF RL   Nat Genet 1992;1:16-23.
#=GF RN   [2]
#=GF RM   8441467
#=GF RT   Putative X-linked adrenoleukodystrophy gene shares unexpected
#=GF RT   homology with ABC transporters. 
#=GF RA   Mosser J, Douar AM, Sarde CO, Kioschis P, Feil R, Moser H,
#=GF RA   Poustka AM, Mandel JL, Aubourg P; 
#=GF RL   Nature 1993;361:726-730.
#=GF RN   [3]
#=GF RM   8670886
#=GF RT   The ABC transporter proteins Pat1 and Pat2 are required for
#=GF RT   import of long-chain fatty acids into peroxisomes of
#=GF RT   Saccharomyces cerevisiae. 
#=GF RA   Hettema EH, van Roermund CW, Distel B, van den Berg M, Vilela C,
#=GF RA   Rodrigues-Pousada C, Wanders RJ, Tabak HF; 
#=GF RL   EMBO J 1996;15:3813-3822.
#=GF DR   INTERPRO; IPR010509;
#=GF CC   This domain covers the transmembrane of a small family of ABC
#=GF CC   transporters and shares sequence similarity with Pfam:PF00664.
#=GF CC   Mutations in this domain in Swiss:P28288 are believed
#=GF CC   responsible for Zellweger Syndrome-2 [1]; mutations in 
#=GF CC   Swiss:P33897 are responsible for recessive X-linked
#=GF CC   adrenoleukodystrophy [2]. A Saccharomyces cerevisiae homolog is
#=GF CC   involved in the import of long-chain fatty acids [3].
#=GF SQ   2221
#=GS G4MBQ3_9BURK/11-302    AC G4MBQ3.1
#=GS Q607T0_METCA/13-285    AC Q607T0.1
#=GS H2PX60_PONAB/65-305    AC H2PX60.1
#=GS Q8Y280_RALSO/22-316    AC Q8Y280.1
#=GS G8MUY8_AGGAC/44-334    AC G8MUY8.1
#=GS E7N331_9FIRM/1-294     AC E7N331.1
#=GS H0GJJ4_9SACH/100-383   AC H0GJJ4.1
#=GS D1DVT0_NEIGO/1-199     AC D1DVT0.1
#=GS B9H532_POPTR/75-356    AC B9H532.1
#=GS D5ZHY7_MYCTU/41-358    AC D5ZHY7.1
#=GS H5PYM0_ECOLX/10-302    AC H5PYM0.1
#=GS H2WCC8_CAEJA/60-348    AC H2WCC8.1
#=GS F7WM07_MYCTC/22-339    AC F7WM07.1
#=GS B2JI01_BURP8/11-297    AC B2JI01.1
#=GS C2LNM1_PROMI/1-250     AC C2LNM1.1
#=GS D2VI66_NAEGR/1-221     AC D2VI66.1
#=GS F9I276_ECOLX/2-293     AC F9I276.1
#=GS B6VBI8_CAEBE/10-292    AC B6VBI8.1
#=GS D2GZW5_AILME/2-282     AC D2GZW5.1
#=GS E1ZGQ0_CHLVA/3-213     AC E1ZGQ0.1
#=GS F1S3G9_PIG/14-294      AC F1S3G9.1
#=GS Q20X83_RHOPB/1-296     AC Q20X83.1
#=GS B8A9Y5_ORYSI/747-993   AC B8A9Y5.1
#=GS E7H6I8_9BURK/7-292     AC E7H6I8.1
#=GS Q0KEH8_CUPNH/23-315    AC Q0KEH8.1
#=GS E2PDR5_NEIPO/1-289     AC E2PDR5.1
#=GS A2GC20_TRIVA/3-277     AC A2GC20.1
#=GS G8GMK4_9CYAN/1-252     AC G8GMK4.1
#=GS G7PHL5_MACFA/78-365    AC G7PHL5.1
#=GS D0GE23_BRUML/45-338    AC D0GE23.1
#=GS D2A4N9_TRICA/81-368    AC D2A4N9.1
#=GS Q3Z1P0_SHISS/10-302    AC Q3Z1P0.1
#=GS B3PNK0_RHIE6/53-347    AC B3PNK0.1
#=GS ABCD3_RAT/57-338       AC P16970.3
#=GS F9GVI7_HAEHA/74-363    AC F9GVI7.1
#=GS H0X0V0_OTOGA/20-301    AC H0X0V0.1
#=GS AB1D_ARATH/80-361      AC Q94FB9.1
#=GS G7MYS8_MACMU/12-292    AC G7MYS8.1
#=GS E9TTR3_ECOLX/10-302    AC E9TTR3.1
#=GS Q6FWG6_CANGA/128-410   AC Q6FWG6.1
#=GS Q18598_CAEEL/60-341    AC Q18598.1
#=GS H3FWD2_PRIPA/45-171    AC H3FWD2.1
#=GS A3P050_BURP0/19-308    AC A3P050.2
#=GS B3B195_ECO57/10-302    AC B3B195.1
#=GS E9HT79_DAPPU/13-293    AC E9HT79.1
#=GS E9V6P7_ECOLX/10-302    AC E9V6P7.1
#=GS F4S1C5_MELLP/86-370    AC F4S1C5.1
#=GS C4S3M2_YERBE/1-293     AC C4S3M2.1
#=GS C0S140_PARBP/127-410   AC C0S140.1
#=GS H4P430_ECOLX/1-271     AC H4P430.1
#=GS H3A6M7_LATCH/56-337    AC H3A6M7.1
#=GS B6QCP9_PENMQ/93-374    AC B6QCP9.1
#=GS B9RKV1_RICCO/88-367    AC B9RKV1.1
#=GS I0GF20_9BRAD/1-296     AC I0GF20.1
#=GS E4LH13_9FIRM/1-294     AC E4LH13.1
#=GS D8SPT5_SELML/66-344    AC D8SPT5.1
#=GS F8Q7A4_SERL3/81-369    AC F8Q7A4.1
#=GS A9IDH4_BORPD/34-325    AC A9IDH4.1
#=GS B6JIX5_OLICO/1-296     AC B6JIX5.1
#=GS G1Y9P5_ECOLX/2-293     AC G1Y9P5.1
#=GS E7M136_YEASV/59-223    AC E7M136.1
#=GS F0AYV2_NEIME/10-290    AC F0AYV2.1
#=GS E1G1Q4_LOALO/11-221    AC E1G1Q4.1
#=GS H0S8U0_9BRAD/25-317    AC H0S8U0.1
#=GS G1LQ34_AILME/65-352    AC G1LQ34.1
#=GS ABCD4_HUMAN/14-294     AC O14678.1
#=GS Q7U9C9_SYNPX/101-377   AC Q7U9C9.1
#=GS H5GBK0_ECOLX/10-302    AC H5GBK0.1
#=GS D7Z3M2_ECOLX/10-274    AC D7Z3M2.1
#=GS D5GDJ6_TUBMM/81-362    AC D5GDJ6.1
#=GS B1XE87_ECODH/8-302     AC B1XE87.1
#=GS I0RCM1_MYCPH/25-343    AC I0RCM1.1
#=GS B7NIH0_ECO7I/10-302    AC B7NIH0.1
#=GS E9WEM9_ECOLX/8-302     AC E9WEM9.1
#=GS I0PSG3_MYCAB/37-343    AC I0PSG3.1
#=GS G5W305_ECOLX/2-293     AC G5W305.1
#=GS H0RSU6_9BRAD/1-296     AC H0RSU6.1
#=GS Q6BUD3_DEBHA/141-423   AC Q6BUD3.2
#=GS H3A7R5_LATCH/79-366    AC H3A7R5.1
#=GS B4CVY0_9BACT/28-306    AC B4CVY0.1
#=GS C9QVX2_ECOD1/8-302     AC C9QVX2.1
#=GS F3IMY4_PSESL/12-302    AC F3IMY4.1
#=GS C7GJ98_YEAS2/181-467   AC C7GJ98.1
#=GS F6WF19_CIOIN/60-341    AC F6WF19.2
#=GS D4XFP4_9BURK/34-325    AC D4XFP4.1
#=GS Q119L9_TRIEI/1-251     AC Q119L9.1
#=GS E2K4T5_ECO57/10-302    AC E2K4T5.1
#=GS C8TEN3_PLARU/41-303    AC C8TEN3.1
#=GS G4ANK2_AGGAC/44-334    AC G4ANK2.1
#=GS H0TL98_9BRAD/1-296     AC H0TL98.1
#=GS D0PLJ5_BRUSS/45-338    AC D0PLJ5.1
#=GS G5TXC1_ECOLX/2-293     AC G5TXC1.1
#=GS G7J3T2_MEDTR/732-1013  AC G7J3T2.1
#=GS E0N917_NEIME/32-323    AC E0N917.1
#=GS Q5CYD8_CRYPI/75-335    AC Q5CYD8.1
#=GS I0GMX0_SELRU/1-295     AC I0GMX0.1
#=GS G6XUU4_RHIRD/51-342    AC G6XUU4.1
#=GS A8P5A8_COPC7/121-424   AC A8P5A8.1
#=GS I1K4J6_SOYBN/9-290     AC I1K4J6.1
#=GS C6HAN4_AJECH/147-430   AC C6HAN4.1
#=GS C7GJ21_YEAS2/100-383   AC C7GJ21.1
#=GS F0YB28_AURAN/66-352    AC F0YB28.1
#=GS B0SL02_LEPBP/6-283     AC B0SL02.1
#=GS A2Q8A9_ASPNC/142-425   AC A2Q8A9.1
#=GS Q064H7_9SYNE/107-377   AC Q064H7.1
#=GS G8NGI5_BRUSS/45-338    AC G8NGI5.1
#=GS H2MST8_ORYLA/14-297    AC H2MST8.1
#=GS B4H855_DROPE/106-393   AC B4H855.1
#=GS Q8GU57_ORYSJ/655-933   AC Q8GU57.1
#=GS H3Q6G3_BRUAO/45-338    AC H3Q6G3.1
#=GS E9PYR0_MOUSE/1-251     AC E9PYR0.1
#=GS D8TJB9_VOLCA/44-317    AC D8TJB9.1
#=GS Q3MCP1_ANAVT/44-303    AC Q3MCP1.1
#=GS C5DS24_ZYGRC/103-385   AC C5DS24.1
#=GS I1KT29_SOYBN/1-169     AC I1KT29.1
#=GS F5Z3L5_MYCSD/41-370    AC F5Z3L5.1
#=GS F0USX3_AJEC8/101-382   AC F0USX3.1
#=GS C9LYP5_9FIRM/2-295     AC C9LYP5.1
#=GS E7KIU6_YEASA/60-346    AC E7KIU6.1
#=GS H2YG43_CIOSA/1-303     AC H2YG43.1
#=GS F1NHC8_CHICK/61-348    AC F1NHC8.1
#=GS H9J526_BOMMO/110-397   AC H9J526.1
#=GS H3QF49_BRUAO/1-310     AC H3QF49.1
#=GS H4YFP1_ECOLX/10-302    AC H4YFP1.1
#=GS D4API0_ARTBC/144-427   AC D4API0.1
#=GS G2RI36_THITE/97-378    AC G2RI36.1
#=GS B9Q9T3_TOXGO/452-717   AC B9Q9T3.1
#=GS E0DW30_9RHIZ/45-338    AC E0DW30.1
#=GS H0I7I7_9MYCO/37-343    AC H0I7I7.1
#=GS Q7CTH2_AGRT5/1-203     AC Q7CTH2.2
#=GS A0YKW3_LYNSP/104-365   AC A0YKW3.1
#=GS C9MF28_HAEIF/31-322    AC C9MF28.1
#=GS Q4C6B9_CROWT/17-293    AC Q4C6B9.1
#=GS C9UAK4_BRUAO/17-329    AC C9UAK4.1
#=GS B8AAK9_ORYSI/109-401   AC B8AAK9.1
#=GS H4KGB4_ECOLX/2-293     AC H4KGB4.1
#=GS G8GMH8_9CYAN/1-252     AC G8GMH8.1
#=GS Q0BIY6_BURCM/16-307    AC Q0BIY6.1
#=GS G4JVG1_9RHIZ/73-368    AC G4JVG1.1
#=GS Q0I7B2_SYNS3/131-399   AC Q0I7B2.1
#=GS H4F4T1_9RHIZ/20-312    AC H4F4T1.1
#=GS G5W5L0_ECOLX/2-293     AC G5W5L0.1
#=GS F3C2B2_PSESG/1-146     AC F3C2B2.1
#=GS B2HSW5_MYCMM/41-358    AC B2HSW5.1
#=GS H5GRK5_ECOLX/1-271     AC H5GRK5.1
#=GS E6R1M3_CRYGW/82-373    AC E6R1M3.1
#=GS F7NPV2_9FIRM/5-291     AC F7NPV2.1
#=GS Q73ZS0_MYCPA/41-358    AC Q73ZS0.1
#=GS C5YY24_SORBI/76-357    AC C5YY24.1
#=GS G8GMK9_9CYAN/1-252     AC G8GMK9.1
#=GS G2UMH8_MYCTU/1-292     AC G2UMH8.1
#=GS E2BU03_HARSA/103-300   AC E2BU03.1
#=GS A8EM90_BURPE/1-266     AC A8EM90.1
#=GS F6VG16_ORNAN/1-230     AC F6VG16.1
#=GS F2QRF0_PICP7/52-335    AC F2QRF0.1
#=GS E0VME4_PEDHC/58-339    AC E0VME4.1
#=GS B4U6T3_HYDS0/12-308    AC B4U6T3.1
#=GS G3SSY5_LOXAF/48-329    AC G3SSY5.1
#=GS F6VG06_ORNAN/1-230     AC F6VG06.1
#=GS F2BG53_9NEIS/1-290     AC F2BG53.1
#=GS C1EBP7_MICSR/1-252     AC C1EBP7.1
#=GS B4MF35_DROVI/102-389   AC B4MF35.1
#=GS H3JPA2_STRPU/1-278     AC H3JPA2.1
#=GS D5QLW4_METTR/124-419   AC D5QLW4.1
#=GS G6DAW3_DANPL/7-198     AC G6DAW3.1
#=GS H1WL99_9CYAN/104-365   AC H1WL99.1
#=GS C9LNQ2_9FIRM/6-139     AC C9LNQ2.1
#=GS A5XR28_BURML/37-326    AC A5XR28.1
#=GS F1KYL7_ASCSU/66-347    AC F1KYL7.1
#=GS E7T011_SHIBO/1-106     AC E7T011.1
#=GS G8GMH3_9CYAN/1-252     AC G8GMH3.1
#=GS Q7WS86_9NOST/45-305    AC Q7WS86.1
#=GS F7TCK8_PASMD/32-323    AC F7TCK8.1
#=GS H5KEN2_ECOLX/10-302    AC H5KEN2.1
#=GS E2RG61_CANFA/78-365    AC E2RG61.1
#=GS G0FFQ1_ECOLX/2-293     AC G0FFQ1.1
#=GS C3TA39_ECOLX/10-302    AC C3TA39.1
#=GS F2ULF8_SALS5/8-129     AC F2ULF8.1
#=GS A3Q0I6_MYCSJ/38-349    AC A3Q0I6.1
#=GS H2ZCN1_CIOSA/1-280     AC H2ZCN1.1
#=GS I0QSL0_9ENTR/5-298     AC I0QSL0.1
#=GS C5GCS0_AJEDR/147-430   AC C5GCS0.1
#=GS G0EVC5_CUPNN/23-315    AC G0EVC5.1
#=GS C6APY9_AGGAN/34-323    AC C6APY9.1
#=GS D8G8L5_9CYAN/96-366    AC D8G8L5.1
#=GS C6NXB0_9GAMM/2-298     AC C6NXB0.1
#=GS F8XHK6_ECOLX/10-302    AC F8XHK6.1
#=GS F1N3B4_BOVIN/14-294    AC F1N3B4.1
#=GS Q576Y9_BRUAB/1-310     AC Q576Y9.1
#=GS B5S8E8_RALSL/22-316    AC B5S8E8.1
#=GS E0ULK4_CYAP2/2-281     AC E0ULK4.1
#=GS G1SML4_RABIT/57-338    AC G1SML4.1
#=GS G1KHZ1_ANOCA/1-258     AC G1KHZ1.1
#=GS G7YHE0_CLOSI/1-131     AC G7YHE0.1
#=GS A4NFC0_HAEIF/31-322    AC A4NFC0.1
#=GS Q3AHC9_SYNSC/103-373   AC Q3AHC9.1
#=GS G9ZJ38_9GAMM/1-289     AC G9ZJ38.1
#=GS F6X7C7_MACMU/51-251    AC F6X7C7.1
#=GS Q6CWP3_KLULA/118-244   AC Q6CWP3.1
#=GS Q0SI05_RHOSR/32-323    AC Q0SI05.1
#=GS Q18597_CAEEL/65-346    AC Q18597.1
#=GS A7TGC7_VANPO/108-234   AC A7TGC7.1
#=GS E4WI10_RHOE1/37-342    AC E4WI10.1
#=GS B0JH77_MICAN/52-312    AC B0JH77.1
#=GS Q5FWT4_RAT/1-68        AC Q5FWT4.1
#=GS F7HXT3_CALJA/1-190     AC F7HXT3.1
#=GS B2G3C7_MICAE/52-312    AC B2G3C7.1
#=GS Q55Z76_CRYNB/131-443   AC Q55Z76.1
#=GS G7R5K8_ECOC2/10-302    AC G7R5K8.1
#=GS H2ZCN2_CIOSA/1-279     AC H2ZCN2.1
#=GS E5U2L2_ALCXX/34-325    AC E5U2L2.1
#=GS E7N1S3_9FIRM/7-305     AC E7N1S3.1
#=GS Q4PFK8_USTMA/125-406   AC Q4PFK8.1
#=GS F5PRL5_SHIFL/10-302    AC F5PRL5.1
#=GS C4YND5_CANAW/144-426   AC C4YND5.1
#=GS Y036_HAEIN/34-323      AC Q57335.1
#=GS D5YFY4_MYCTU/41-358    AC D5YFY4.1
#=GS C7KI87_ACEPA/1-307     AC C7KI87.1
#=GS E2KFB7_ECO57/10-302    AC E2KFB7.1
#=GS A3LS12_PICST/143-425   AC A3LS12.2
#=GS E5UIB1_NEIMU/32-323    AC E5UIB1.1
#=GS F4BHY9_FRACN/2-289     AC F4BHY9.1
#=GS B3HU95_ECOLX/10-302    AC B3HU95.1
#=GS B8A9Y5_ORYSI/79-360    AC B8A9Y5.1
#=GS C1GPV1_PARBA/1-170     AC C1GPV1.1
#=GS F7AP57_MACMU/1-135     AC F7AP57.1
#=GS G5J2C2_CROWT/6-286     AC G5J2C2.1
#=GS C5JB24_9BACT/5-307     AC C5JB24.1
#=GS B1ME06_MYCA9/37-350    AC B1ME06.1
#=GS H9KGW8_APIME/61-342    AC H9KGW8.1
#=GS G1S2G7_NOMLE/14-293    AC G1S2G7.1
#=GS H4T414_ECOLX/1-271     AC H4T414.1
#=GS G3R2Y1_GORGO/31-312    AC G3R2Y1.1
#=GS Q130Y8_RHOPS/48-343    AC Q130Y8.1
#=GS G3AJB8_SPAPN/147-429   AC G3AJB8.1
#=GS C5TB01_ACIDE/7-287     AC C5TB01.1
#=GS F1KWC1_ASCSU/4-289     AC F1KWC1.1
#=GS AB1D_ARATH/734-1015    AC Q94FB9.1
#=GS G6CU36_DANPL/64-343    AC G6CU36.1
#=GS I0YH70_9BURK/11-302    AC I0YH70.1
#=GS D1RZM7_SEROD/2-295     AC D1RZM7.1
#=GS B0S598_DANRE/65-352    AC B0S598.1
#=GS D8PRR8_SCHCM/84-359    AC D8PRR8.1
#=GS C3TA40_ECOLX/10-302    AC C3TA40.1
#=GS H2NGZ1_PONAB/78-365    AC H2NGZ1.1
#=GS A8N2A3_COPC7/76-364    AC A8N2A3.2
#=GS Q7SD69_NEUCR/139-422   AC Q7SD69.1
#=GS C9V359_BRUAO/17-329    AC C9V359.1
#=GS A0ZF89_NODSP/44-303    AC A0ZF89.1
#=GS H4LNK9_ECOLX/1-271     AC H4LNK9.1
#=GS G0TE97_9NOSO/43-303    AC G0TE97.1
#=GS E2AJU7_CAMFO/62-343    AC E2AJU7.1
#=GS G8GMJ8_9CYAN/1-252     AC G8GMJ8.1
#=GS F4TG11_ECOLX/10-302    AC F4TG11.1
#=GS E9XKA9_ECOLX/10-302    AC E9XKA9.1
#=GS B1WWU7_CYAA5/13-293    AC B1WWU7.1
#=GS E5UL56_NEIMU/1-290     AC E5UL56.1
#=GS D8CII7_ECOLX/10-302    AC D8CII7.1
#=GS D2I7R0_AILME/78-365    AC D2I7R0.1
#=GS Q5E9I5_BOVIN/1-135     AC Q5E9I5.1
#=GS G0JNP4_9GAMM/2-298     AC G0JNP4.1
#=GS F9QR94_9MYCO/10-342    AC F9QR94.1
#=GS F5GUC6_CAEEL/32-314    AC F5GUC6.1
#=GS I1FV57_AMPQE/200-330   AC I1FV57.1
#=GS B7G8L4_PHATC/2-265     AC B7G8L4.1
#=GS F9Q6K1_9PAST/1-291     AC F9Q6K1.1
#=GS G5URG1_ECOLX/2-293     AC G5URG1.1
#=GS C7K0U1_ACEPA/1-307     AC C7K0U1.1
#=GS C0G9L0_9RHIZ/17-329    AC C0G9L0.1
#=GS Q0THT0_ECOL5/10-302    AC Q0THT0.1
#=GS B9EWM5_ORYSJ/79-360    AC B9EWM5.1
#=GS C5DXQ8_ZYGRC/189-475   AC C5DXQ8.1
#=GS A4CQQ1_SYNPV/100-374   AC A4CQQ1.1
#=GS E3GUV8_HAEI2/31-322    AC E3GUV8.1
#=GS E8T9I5_MESCW/19-312    AC E8T9I5.1
#=GS C3TA37_ECOLX/10-302    AC C3TA37.1
#=GS G5GS80_9FIRM/7-292     AC G5GS80.1
#=GS D0W7C4_NEILA/32-323    AC D0W7C4.1
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