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Database: Pfam
Entry: AKAP7_RIRII_bdg
LinkDB: AKAP7_RIRII_bdg
Original site: AKAP7_RIRII_bdg 
#=GF ID   AKAP7_RIRII_bdg
#=GF AC   PF10470.7
#=GF DE   PKA-RI-RII subunit binding domain of A-kinase anchor protein
#=GF AU   Buljan M, Coggill P
#=GF SE   TreeFam_TF105406
#=GF GA   22.70 22.70;
#=GF TC   23.50 23.20;
#=GF NC   21.60 18.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   12804576
#=GF RT   AKAP7gamma is a nuclear RI-binding AKAP. 
#=GF RA   Brown RL, August SL, Williams CJ, Moss SB; 
#=GF RL   Biochem Biophys Res Commun. 2003;306:394-401.
#=GF RN   [2]
#=GF RM   16483255
#=GF RT   High-affinity AKAP7delta-protein kinase A interaction yields
#=GF RT   novel protein kinase A-anchoring disruptor peptides. 
#=GF RA   Hundsrucker C, Krause G, Beyermann M, Prinz A, Zimmermann B,
#=GF RA   Diekmann O, Lorenz D, Stefan E, Nedvetsky P, Dathe M, Christian
#=GF RA   F, McSorley T, Krause E, McConnachie G, Herberg FW, Scott JD,
#=GF RA   Rosenthal W, Klussmann E; 
#=GF RL   Biochem J. 2006;396:297-306.
#=GF DR   INTERPRO; IPR019511;
#=GF CC   AKAP7_RIRII_bdg is the C-terminal domain of the cyclic
#=GF CC   AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This
#=GF CC   protein anchors PKA, for its role in regulating PKA-mediated
#=GF CC   gene transcription in both somatic cells and oocytes, by binding
#=GF CC   to its regulatory subunits, RI and RII, hence being known as a
#=GF CC   dual-specific AKAP [1]. The 25 crucial amino acids of
#=GF CC   RII-binding domains in general form structurally conserved
#=GF CC   amphipathic helices with unrelated sequences; hydrophobic amino
#=GF CC   acid residues form the backbone of the interaction and hydrogen
#=GF CC   bond- and salt-bridge-forming amino acid residues increase the
#=GF CC   affinity of the interaction [2]. The N-terminus, of family
#=GF CC   AKAP7_NLS, carries the nuclear localisation signal.
#=GF SQ   64
#=GS G1RVY0_NOMLE/372-429      AC G1RVY0.2
#=GS E7FAL2_DANRE/366-414      AC E7FAL2.1
#=GS AKA7G_RAT/294-351         AC Q6JP77.1
#=GS AKA7G_RAT/294-351         DR PDB; 3J4Q A; 294-317;
#=GS AKA7G_RAT/294-351         DR PDB; 3J4R A; 294-317;
#=GS M3WSN8_FELCA/11-56        AC M3WSN8.1
#=GS A0A091D9B7_FUKDA/328-385  AC A0A091D9B7.1
#=GS J9NW88_CANLF/11-58        AC J9NW88.1
#=GS F7IC49_CALJA/22-79        AC F7IC49.1
#=GS A0A096NC89_PAPAN/11-56    AC A0A096NC89.1
#=GS H0ZN63_TAEGU/216-273      AC H0ZN63.1
#=GS J3KN37_HUMAN/25-82        AC J3KN37.1
#=GS F6ZQQ1_MACMU/45-102       AC F6ZQQ1.1
#=GS H2QTQ9_PANTR/267-324      AC H2QTQ9.1
#=GS H3ASR7_LATCH/372-427      AC H3ASR7.2
#=GS G1MNW5_AILME/9-56         AC G1MNW5.1
#=GS H0XR10_OTOGA/20-77        AC H0XR10.1
#=GS A0A0A0MXX1_RAT/293-350    AC A0A0A0MXX1.1
#=GS J3KS16_HUMAN/18-60        AC J3KS16.1
#=GS H2UJZ8_TAKRU/253-312      AC H2UJZ8.1
#=GS AKA7A_HUMAN/45-102        AC O43687.4
#=GS L9KYD1_TUPCH/11-66        AC L9KYD1.1
#=GS G3R0A1_GORGO/283-340      AC G3R0A1.1
#=GS I3MQZ9_ICTTR/232-289      AC I3MQZ9.1
#=GS CR042_HUMAN/11-54         AC P0CW23.1
#=GS AKA7G_MOUSE/255-312       AC Q7TN79.2
#=GS G1NKF9_MELGA/45-102       AC G1NKF9.1
#=GS F7B585_MONDO/462-519      AC F7B585.2
#=GS F7I9X3_CALJA/267-324      AC F7I9X3.1
#=GS F7DE14_CALJA/11-55        AC F7DE14.1
#=GS A0A0D9RYC8_CHLSB/11-56    AC A0A0D9RYC8.1
#=GS A0A087XXN2_POEFO/441-505  AC A0A087XXN2.2
#=GS G3VFW8_SARHA/22-79        AC G3VFW8.1
#=GS G1P715_MYOLU/283-340      AC G1P715.1
#=GS H2PKB8_PONAB/267-324      AC H2PKB8.2
#=GS F7IC71_CALJA/23-80        AC F7IC71.1
#=GS G1KYP3_ANOCA/7-65         AC G1KYP3.1
#=GS M3YT80_MUSPF/258-315      AC M3YT80.1
#=GS G3HT52_CRIGR/9-57         AC G3HT52.1
#=GS F6ZQQ8_MACMU/267-324      AC F6ZQQ8.1
#=GS S9WLG8_9CETA/34-90        AC S9WLG8.1
#=GS G3RN25_GORGO/10-54        AC G3RN25.1
#=GS H2RG99_PANTR/11-68        AC H2RG99.1
#=GS F7IRN7_CALJA/289-346      AC F7IRN7.1
#=GS AKA7A_MOUSE/22-79         AC O55074.4
#=GS G3TSA7_LOXAF/24-81        AC G3TSA7.1
#=GS U3JUZ0_FICAL/11-68        AC U3JUZ0.1
#=GS M3ZY69_XIPMA/453-517      AC M3ZY69.1
#=GS G1SA96_NOMLE/10-53        AC G1SA96.1
#=GS G7PWF2_MACFA/10-55        AC G7PWF2.1
#=GS G5C774_HETGA/236-293      AC G5C774.1
#=GS G1M3N8_AILME/22-79        AC G1M3N8.1
#=GS F6YG35_HORSE/267-324      AC F6YG35.1
#=GS Q5RIX0_DANRE/66-114       AC Q5RIX0.2
#=GS G1T6I1_RABIT/272-329      AC G1T6I1.2
#=GS W5P194_SHEEP/6-47         AC W5P194.1
#=GS I3ND12_ICTTR/10-65        AC I3ND12.1
#=GS R4GI69_CHICK/11-68        AC R4GI69.1
#=GS U3KB21_FICAL/22-79        AC U3KB21.1
#=GS H3D040_TETNG/254-313      AC H3D040.1
#=GS E2RMB3_CANLF/267-324      AC E2RMB3.2
#=GS A0A0D9RVQ3_CHLSB/289-345  AC A0A0D9RVQ3.1
#=GS G3UUN3_MELGA/6-63         AC G3UUN3.1
#=GS G7P361_MACFA/267-324      AC G7P361.1
#=GS F7IC51_CALJA/45-102       AC F7IC51.1
#=GS AKA7G_HUMAN/289-346       AC Q9P0M2.2
G1RVY0_NOMLE/372-429                 ..GEPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.N.KPGE...GS.SVKTEAADQNGNDNENN.....................
E7FAL2_DANRE/366-414                 sa--PDDEELLSLSKRLVEDAVLRAMQQYMEET.QQNgA.AHTD...--.-----------------qahsklnst............
AKA7G_RAT/294-351                    ..KEPEDAELVRLSKRLVENAVLKAVQQYLEET.QNK.K.QPGE...GN.SVKAEEGDRNG-DGSDNn....................
#=GR AKA7G_RAT/294-351         SS    ..SSSS---STTHHHHHHHHHHHHH-XXXXXXX.XXX.X.XXXX...XX.XXXXXXXXXXX-XXXXXX....................
M3WSN8_FELCA/11-56                   .n-EPEEVKLQKASKQIVQHAILQAVQQVSQES.RQR.EdRTG-...--.-----------------dnqgnfq..............
A0A091D9B7_FUKDA/328-385             ..GEPDDAELVKLSKRLVENAVLKAVQQYLEET.QNK.K.QPGE...GS.SVKAEEADRSG-SGSDNn....................
J9NW88_CANLF/11-58                   .n-EPEEVKLQKASKQIVQNAILQAVQQVSQES.QQR.G.ERTS...--.-----------------dsrgslqlg............
F7IC49_CALJA/22-79                   ..GEPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.N.KPGE...GS.SVKTEAADRNGNDNENN.....................
A0A096NC89_PAPAN/11-56               .n-EPEEVKLQNASKQIVQNAILRAVQQVSQES.QRR.E.ER--...--.-----------------isdnqghiq............
H0ZN63_TAEGU/216-273                 ..AEPDDAELVSLSKRLVENAVLKAVQQYLEET.QNK.S.RQTD...GS.PAKTEEAASSNKNESDN.....................
J3KN37_HUMAN/25-82                   ..GEPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.N.KPGE...GS.SVKTEAADQNGNDNENN.....................
F6ZQQ1_MACMU/45-102                  ..GEPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.N.KPGE...GS.SVKTEAADRNGNDNENN.....................
H2QTQ9_PANTR/267-324                 ..GEPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.N.KPGE...GS.SVKTEAADQNGNDNENN.....................
H3ASR7_LATCH/372-427                 .v-EPDDAELVSLSKRLVENAVLRAVQQYLEET.QNK.S.KRTD...SS.PAKSEEAANSN-DN---sk...................
G1MNW5_AILME/9-56                    .s-EPEEVKLQKASKQIVQNAIQQAVQQVSQES.RQR.G.ER--...--.-----------------ardsrgslqlg..........
H0XR10_OTOGA/20-77                   ..GEPDDAELVRLSKRLVENAVLKAVQQYLDET.QNK.N.KPGE...GS.SVKTEEADRNGHDSENN.....................
A0A0A0MXX1_RAT/293-350               ..KEPEDAELVRLSKRLVENAVLKAVQQYLEET.QNK.K.QPGE...GN.SVKAEEGDRNG-DGSDNn....................
J3KS16_HUMAN/18-60                   .n-EPEEVKLQNASKQIVQNAILQAVQQVSQES.QRR.E.ER--...--.-----------------isdnrd...............
H2UJZ8_TAKRU/253-312                 .s-EPDEAELLRVSKRLVEDAVSRALQQYKQETlQNG.G.GPQA..pGN.AEETVTK----------tgttansttd...........
AKA7A_HUMAN/45-102                   ..GEPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.N.KPGE...GS.SVKTEAADQNGNDNENN.....................
L9KYD1_TUPCH/11-66                   .n-EPEEVKLQNASRQIVHNAILQAVRQVSQES.QQR.EeRTRD...G-.-----------------rgslqlgvgeltkkh......
G3R0A1_GORGO/283-340                 ..GEPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.N.KPGE...GS.SVKTEAADQNGNDNENN.....................
I3MQZ9_ICTTR/232-289                 ..GEPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.K.QLGE...GS.SVKIEEAERNG-NDSDNn....................
CR042_HUMAN/11-54                    .n-EPEEVKLQNASKQIVQNAILQAVQQVSQES.QRR.E.ER--...--.-----------------isdnrdh..............
AKA7G_MOUSE/255-312                  ..REPEDAELVRLSKRLVENAVLKAVQQYLEET.QNK.K.QPGE...GN.STKAEEGDRNG-DGSDNn....................
G1NKF9_MELGA/45-102                  ..AEPDDAELVSLSKRLVENAVLKAVQQYLEET.QNK.A.RQTD...GS.PLKAEEAASGTKNESNN.....................
F7B585_MONDO/462-519                 ..REPDDAELVRLSKKLVENAVLKAVQQYLEET.QNK.T.RQVD...GS.PVKAEEPMQSDRNDSDN.....................
F7I9X3_CALJA/267-324                 ..GEPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.N.KPGE...GS.SVKTEAADRNGNDNENN.....................
F7DE14_CALJA/11-55                   .n-EPEEVKLQNASKQIVQNAILQAMRQVSQES.QHR.E.ER--...--.-----------------isdsrggi.............
A0A0D9RYC8_CHLSB/11-56               .n-EPEEVKLQNASKQIVQNAILQAVQQVSQES.QRR.E.ER--...--.-----------------isdnqghiq............
A0A087XXN2_POEFO/441-505             .s-EPDEAELLRVSRRLVEDAVSRALQQYKQETlQNG.G.GPNAaalQT.PGSTEETKT--------dttansstdnr..........
G3VFW8_SARHA/22-79                   ..REPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.A.RQVD...GS.PVKPTEPGHADTNNSDN.....................
G1P715_MYOLU/283-340                 ..GEPDDAELVKLSKRLVENAVLKAVQQYLEET.QNK.H.KPGD...GS.TVKTEEADRNGTDNDN-r....................
H2PKB8_PONAB/267-324                 ..GEPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.N.KPGE...GS.SVKTEAADQNGNDNENN.....................
F7IC71_CALJA/23-80                   ..GEPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.N.KPGE...GS.SVKTEAADRNGNDNENN.....................
G1KYP3_ANOCA/7-65                    ..AEPDDAELLSLSKRLVENAVLKAVQQYLEET.QNK.N.RQLD..fGA.PVKTEEPTLG--NNMENgn...................
M3YT80_MUSPF/258-315                 ..GEPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.S.KPGD...GS.SVKTQEAGRNGTESDNN.....................
G3HT52_CRIGR/9-57                    .n-EPEEAKLQNASKQIVQNAILRAVQQVSQESlQRG.G.RPSD...C-.-----------------rprgrlgg.............
F6ZQQ8_MACMU/267-324                 ..GEPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.N.KPGE...GS.SVKTEAADRNGNDNENN.....................
S9WLG8_9CETA/34-90                   .s-EPEEAKLQSASRQIVQNAILQAVHQVSREA.RRReA.RTSD...GR.-----------------gsrqpgvgeltkkhe......
G3RN25_GORGO/10-54                   .n-EPEEVKLQNASKQIVQNAILQAVQQVSQES.QRR.E.ER--...--.-----------------isdnkdhi.............
H2RG99_PANTR/11-68                   .n-EPEEVKLQNASKQIVQNAILQAVQQVSQES.QRR.E.ER--...--.-----------------isdnrdhiqlavgeltkknek
F7IRN7_CALJA/289-346                 ..GEPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.N.KPGE...GS.SVKTEAADRNGNDNENN.....................
AKA7A_MOUSE/22-79                    ..REPEDAELVRLSKRLVENAVLKAVQQYLEET.QNK.K.QPGE...GN.STKAEEGDRNG-DGSDNn....................
G3TSA7_LOXAF/24-81                   ..GEPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.N.KPGD...GN.SVKPEEADRNV-NDSDNn....................
U3JUZ0_FICAL/11-68                   .t-EQDEIKLQIASKQIVQTAILRAVQQVSQES.QQN.E.KRTN..tGT.SLQLERGKLTKKHE---kk...................
M3ZY69_XIPMA/453-517                 .s-EPDEAELLRVSRRLVEDAVSRALQQYKQETlQNG.G.GPNAaalQT.PGSTEETKT--------dttansstdnr..........
G1SA96_NOMLE/10-53                   .n-EPEEVMLQNASKQIVQNAILQAVQQVSQES.QHR.E.ER--...--.-----------------isdnrdh..............
G7PWF2_MACFA/10-55                   .n-EPEEVKLQNASKQIVQNAILRAVQQVSQES.QRR.E.ER--...--.-----------------isdnqghiq............
G5C774_HETGA/236-293                 ..AEPDDVELVRLSKRLVENAVLKAVQQYLEET.QNK.K.QPGE...GS.SVKAEEADGSG-NGSDNn....................
G1M3N8_AILME/22-79                   ..GEPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.S.KPGD...GS.SVKTQEADRNGTDSDNN.....................
F6YG35_HORSE/267-324                 ..GEPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.N.KPGD...GS.SVKTEEADRNGTDSDNN.....................
Q5RIX0_DANRE/66-114                  sa--PDDEELLSLSKRLVEDAVLRAMQQYMEET.QQNgA.AHTD...--.-----------------qahsklnst............
G1T6I1_RABIT/272-329                 ..GEPDDAELLRLSKRLVENAVLKAVQQYLEET.QNK.K.QPGE...GS.SVKTGEAERNGNDSDH-n....................
W5P194_SHEEP/6-47                    .s-EPEEAKLQTTSRQIVQNAILRAVQQVSRES.QSR.R.RDT-...--.-----------------ragd.................
I3ND12_ICTTR/10-65                   .n-EPEEVKLQNASKQIVQNAILQAVQQVSQES.QPQ.E.D---...--.-----------------rssdargrsqlgvqeltkkh.
R4GI69_CHICK/11-68                   .p-EQDEVKLQNASKQIVQTAILQAVQQVSREN.QQK.E.KRTN...SSmSLQLE------------rgkltkkhekk..........
U3KB21_FICAL/22-79                   ..AEPDDAELVSLSKRLVENAVLKAVQQYLEET.QNK.S.RQTD...GS.PAKTEEAASGSKNESDN.....................
H3D040_TETNG/254-313                 .s-EPDEAELLRVSRRLVEDAVSRALQQYKQESlQNG.G.GPQS..pGN.AEETATK----------tgttanstad...........
E2RMB3_CANLF/267-324                 ..GEPDDAELLRLSKRLVENAVLKAVQQYLEET.QSR.G.KPAD...GS.SGKARAADRGGADGDQ-s....................
A0A0D9RVQ3_CHLSB/289-345             ..GEPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.N.KPGE...GS.SVKTEAADRNG-NDNEN.....................
G3UUN3_MELGA/6-63                    .p-EQDEVKLQNASKQIVQTAILQAVQQVSREN.QQK.E.KRTN...SS.M----------------sfqlergkltkkhekk.....
G7P361_MACFA/267-324                 ..GEPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.N.KPGE...GS.SVKTEAADRNGNDNENN.....................
F7IC51_CALJA/45-102                  ..GEPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.N.KPGE...GS.SVKTEAADRNGNDNENN.....................
AKA7G_HUMAN/289-346                  ..GEPDDAELVRLSKRLVENAVLKAVQQYLEET.QNK.N.KPGE...GS.SVKTEAADQNGNDNENN.....................
#=GC SS_cons                         ..SSSS---STTHHHHHHHHHHHHH-XXXXXXX.XXX.X.XXXX...XX.XXXXXXXXXXX-XXXXXX....................
#=GC seq_cons                        ...EPDDAELl+LSKRLVENAVL+AVQQYhEET.QNK.s.css-...Gs.sscsptstts..pt........................
//
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