GenomeNet

Database: Pfam
Entry: AKAP7_RIRII_bdg
LinkDB: AKAP7_RIRII_bdg
Original site: AKAP7_RIRII_bdg 
#=GF ID   AKAP7_RIRII_bdg
#=GF AC   PF10470.4
#=GF DE   PKA-RI-RII subunit binding domain of A-kinase anchor protein
#=GF AU   Buljan M, Coggill P
#=GF SE   TreeFam_TF105406
#=GF GA   22.70 22.70;
#=GF TC   22.70 23.20;
#=GF NC   22.00 22.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   12804576
#=GF RT   AKAP7gamma is a nuclear RI-binding AKAP. 
#=GF RA   Brown RL, August SL, Williams CJ, Moss SB; 
#=GF RL   Biochem Biophys Res Commun. 2003;306:394-401.
#=GF RN   [2]
#=GF RM   16483255
#=GF RT   High-affinity AKAP7delta-protein kinase A interaction yields
#=GF RT   novel protein kinase A-anchoring disruptor peptides. 
#=GF RA   Hundsrucker C, Krause G, Beyermann M, Prinz A, Zimmermann B,
#=GF RA   Diekmann O, Lorenz D, Stefan E, Nedvetsky P, Dathe M, Christian
#=GF RA   F, McSorley T, Krause E, McConnachie G, Herberg FW, Scott JD,
#=GF RA   Rosenthal W, Klussmann E; 
#=GF RL   Biochem J. 2006;396:297-306.
#=GF DR   INTERPRO; IPR019511;
#=GF CC   AKAP7_RIRII_bdg is the C-terminal domain of the cyclic
#=GF CC   AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This
#=GF CC   protein anchors PKA, for its role in regulating PKA-mediated
#=GF CC   gene transcription in both somatic cells and oocytes, by binding
#=GF CC   to its regulatory subunits, RI and RII, hence being known as a
#=GF CC   dual-specific AKAP [1]. The 25 crucial amino acids of
#=GF CC   RII-binding domains in general form structurally conserved
#=GF CC   amphipathic helices with unrelated sequences; hydrophobic amino
#=GF CC   acid residues form the backbone of the interaction and hydrogen
#=GF CC   bond- and salt-bridge-forming amino acid residues increase the
#=GF CC   affinity of the interaction [2]. The N-terminus, of family
#=GF CC   AKAP7_NLS, carries the nuclear localisation signal.
#=GF SQ   57
#=GS G1RVY0_NOMLE/288-348  AC G1RVY0.1
#=GS H2PKB8_PONAB/21-81    AC H2PKB8.1
#=GS Q5RIX0_DANRE/22-72    AC Q5RIX0.1
#=GS Q6P4D3_HUMAN/21-81    AC Q6P4D3.1
#=GS AKAP7_MOUSE/21-81     AC O55074.3
#=GS AKA7G_HUMAN/288-348   AC Q9P0M2.2
#=GS G1M3N8_AILME/21-81    AC G1M3N8.1
#=GS G3RN25_GORGO/9-66     AC G3RN25.1
#=GS F7IC51_CALJA/44-104   AC F7IC51.1
#=GS Q2TAJ5_HUMAN/21-81    AC Q2TAJ5.1
#=GS G1RVY5_NOMLE/44-104   AC G1RVY5.1
#=GS G7NKE0_MACMU/9-66     AC G7NKE0.1
#=GS G1P715_MYOLU/282-341  AC G1P715.1
#=GS H2QTQ9_PANTR/266-326  AC H2QTQ9.1
#=GS Q7TN79_MOUSE/254-314  AC Q7TN79.1
#=GS G3R0A1_GORGO/282-342  AC G3R0A1.1
#=GS G1RVY4_NOMLE/21-81    AC G1RVY4.1
#=GS H3D040_TETNG/253-313  AC H3D040.1
#=GS F6ZQQ1_MACMU/44-104   AC F6ZQQ1.1
#=GS F1S3N0_PIG/21-81      AC F1S3N0.1
#=GS G7PWF2_MACFA/9-66     AC G7PWF2.1
#=GS F6ZQQ8_MACMU/266-326  AC F6ZQQ8.1
#=GS G3X9Q5_MOUSE/21-81    AC G3X9Q5.1
#=GS G1KYP3_ANOCA/6-66     AC G1KYP3.1
#=GS G3UUN3_MELGA/4-61     AC G3UUN3.1
#=GS G3TSA7_LOXAF/23-83    AC G3TSA7.1
#=GS F6YG35_HORSE/266-326  AC F6YG35.1
#=GS F7B585_MONDO/257-318  AC F7B585.1
#=GS G1NKF9_MELGA/44-104   AC G1NKF9.1
#=GS D3ZMQ5_RAT/288-348    AC D3ZMQ5.1
#=GS G7MQD6_MACMU/266-326  AC G7MQD6.1
#=GS F7IC71_CALJA/22-82    AC F7IC71.1
#=GS H2RG99_PANTR/10-69    AC H2RG99.1
#=GS E7FAL2_DANRE/365-415  AC E7FAL2.1
#=GS G1SA96_NOMLE/9-66     AC G1SA96.1
#=GS F1PTI1_CANFA/19-79    AC F1PTI1.1
#=GS E1C0B6_CHICK/45-105   AC E1C0B6.1
#=GS AKA7A_HUMAN/44-104    AC O43687.4
#=GS H2UJZ8_TAKRU/252-311  AC H2UJZ8.1
#=GS G7P361_MACFA/266-326  AC G7P361.1
#=GS CR042_HUMAN/10-67     AC P0CW23.1
#=GS F7I9X3_CALJA/266-326  AC F7I9X3.1
#=GS F8VQ58_MOUSE/254-314  AC F8VQ58.1
#=GS Q6JP77_RAT/293-353    AC Q6JP77.1
#=GS F7DE14_CALJA/10-52    AC F7DE14.1
#=GS H9ERW6_MACMU/21-81    AC H9ERW6.1
#=GS F7IC49_CALJA/21-81    AC F7IC49.1
#=GS H0XR10_OTOGA/19-79    AC H0XR10.1
#=GS G3HT52_CRIGR/8-51     AC G3HT52.1
#=GS Q8BVR3_MOUSE/1-60     AC Q8BVR3.1
#=GS D2I4L4_AILME/6-66     AC D2I4L4.1
#=GS G1TZ82_RABIT/22-82    AC G1TZ82.1
#=GS F7IRN7_CALJA/288-348  AC F7IRN7.1
#=GS G3VFW8_SARHA/21-82    AC G3VFW8.1
#=GS G1T6I1_RABIT/280-340  AC G1T6I1.1
#=GS G5C774_HETGA/235-295  AC G5C774.1
#=GS H0ZN63_TAEGU/215-276  AC H0ZN63.1
G1RVY0_NOMLE/288-348             ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GEG..SSVK.TEAA.DQ.NGNDNENNRK.......................
H2PKB8_PONAB/21-81               ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GEG..SSVK.TEAA.DQ.NGNDNENNRK.......................
Q5RIX0_DANRE/22-72               ....SSAPDDEELLSLSKRLVEDAVLRAMQQYMEETQ---QN.GAA..HTDQ.AHS-.--.----KLNSTK.......................
Q6P4D3_HUMAN/21-81               ...g-GEPDDAELVRLSKRLMENAVLKAVQQYLEETQNKNKP.GEG..SSVK.TEAA.DQ.NGNDNENNRK.......................
AKAP7_MOUSE/21-81                ....RKEPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQP.GEG..NSVK.AEEG.DR.NGDGSDNNRK.......................
AKA7G_HUMAN/288-348              ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GEG..SSVK.TEAA.DQ.NGNDNENNRK.......................
G1M3N8_AILME/21-81               ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKSKP.GDG..SSVK.TQEA.DR.NGTDSDNNRK.......................
G3RN25_GORGO/9-66                ...g-NEPEEVKLQNASKQIVQNAILQAVQQVSQESQRRE--.---..----.----.--.----------erisdnkdhiqlgvgeltkkhe.
F7IC51_CALJA/44-104              ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GEG..SSVK.TEAA.DR.NGNDNENNRK.......................
Q2TAJ5_HUMAN/21-81               ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GEG..SSVK.TEAA.DQ.NGNDNENNRK.......................
G1RVY5_NOMLE/44-104              ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GEG..SSVK.TEAA.DQ.NGNDNENNRK.......................
G7NKE0_MACMU/9-66                ...g-NEPEEVKLQNASKQIVQNAILRAVQQVSQESQRRE--.---..----.----.--.----------erisdnqghiqlgvgeltkkhe.
G1P715_MYOLU/282-341             ...g-GEPDDAELVKLSKRLVENAVLKAVQQYLEETQNKHKP.GDG..STVK.TEEA.DR.NGTDNDNR--k......................
H2QTQ9_PANTR/266-326             ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GEG..SSVK.TEAA.DQ.NGNDNENNRK.......................
Q7TN79_MOUSE/254-314             ....RREPEDAELVRLSKRLVENAVLKAAQQYLEETQNKKQP.GEG..NSTK.AEEG.DR.NGDGSDNNRK.......................
G3R0A1_GORGO/282-342             ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GEG..SSVK.TEAA.DQ.NGNDNENNRK.......................
G1RVY4_NOMLE/21-81               ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GEG..SSVK.TEAA.DQ.NGNDNENNRK.......................
H3D040_TETNG/253-313             ....RSEPDEAELLRVSRRLVEDAVSRALQQYKQESL---QN.GGGpqSPGN.AEET.AT.----------ktgttanstad............
F6ZQQ1_MACMU/44-104              ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GEG..SSVK.TEAA.DR.NGNDNENNRK.......................
F1S3N0_PIG/21-81                 ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GDG..SSVK.TEEA.DR.NGTDSDNNRK.......................
G7PWF2_MACFA/9-66                ...g-NEPEEVKLQNASKQIVQNAILRAVQQVSQESQRRE--.---..----.----.--.----------erisdnqghiqlgvgeltkkhe.
F6ZQQ8_MACMU/266-326             ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GEG..SSVK.TEAA.DR.NGNDNENNRK.......................
G3X9Q5_MOUSE/21-81               ....RREPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQP.GEG..NSTK.AEEG.DR.NGDGSDNNRK.......................
G1KYP3_ANOCA/6-66                ...g-AEPDDAELLSLSKRLVENAVLKAVQQYLEETQNKNRQlDFG..APVK.TEE-.PT.LGNNMEN---gng....................
G3UUN3_MELGA/4-61                pgpe---QDEVKLQNASKQIVQTAILQAVQQVSRENQQKEKR.TNS..----.----.--.----------smsfqlergkltkkhe.......
G3TSA7_LOXAF/23-83               ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GDG..NSVK.PEEA.DR.NVNDSDNNRK.......................
F6YG35_HORSE/266-326             ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GDG..SSVK.TEEA.DR.NGTDSDNNKK.......................
F7B585_MONDO/257-318             ...g-REPDDAELVRLSKKLVENAVLKAVQQYLEETQNKTRQ.VDG..SPVK.AEEP.MQsDRNDSDNNRK.......................
G1NKF9_MELGA/44-104              ...a-AEPDDAELVSLSKRLVENAVLKAVQQYLEETQNKARQ.TDG..SPLK.AEEA.AS.GTKNESNN--dn.....................
D3ZMQ5_RAT/288-348               ....RKEPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQP.GEG..NSVK.AEEG.DR.NGDGSDNNRK.......................
G7MQD6_MACMU/266-326             ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GEG..SSVK.TEAA.DR.NGNDNENNRK.......................
F7IC71_CALJA/22-82               ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GEG..SSVK.TEAA.DR.NGNDNENNRK.......................
H2RG99_PANTR/10-69               ...g-NEPEEVKLQNASKQIVQNAILQAVQQVSQESQRREE-.---..----.----.--.----------risdnrdhiqlavgeltkknekk
E7FAL2_DANRE/365-415             ....SSAPDDEELLSLSKRLVEDAVLRAMQQYMEETQ---QN.GAA..HTDQ.AHS-.--.----KLNSTK.......................
G1SA96_NOMLE/9-66                ...g-NEPEEVMLQNASKQIVQNAILQAVQQVSQESQHRE--.---..----.----.--.----------erisdnrdhiqlgvgeltkkhe.
F1PTI1_CANFA/19-79               ...g-GEPDDAELLRLSKRLVENAVLKAVQQYLEETQSRGKP.ADG..SSGK.ARAA.DR.GGADGDQS--gr.....................
E1C0B6_CHICK/45-105              ...a-AEPDDAELVSLSKRLVENAVLKAVQQYLEETQNKARQ.TDG..SPVK.AEEA.AS.GTKSESNN--dn.....................
AKA7A_HUMAN/44-104               ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GEG..SSVK.TEAA.DQ.NGNDNENNRK.......................
H2UJZ8_TAKRU/252-311             ....RSEPDEAELLRVSKRLVEDAVSRALQQYKQETL---QN.GGG..PQ--.----.--.----------apgnaeetvtktgttanstt...
G7P361_MACFA/266-326             ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GEG..SSVK.TEAA.DR.NGNDNENNRK.......................
CR042_HUMAN/10-67                ...g-NEPEEVKLQNASKQIVQNAILQAVQQVSQESQRRE--.---..----.----.--.----------erisdnrdhiqlgvgeltkkhe.
F7I9X3_CALJA/266-326             ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GEG..SSVK.TEAA.DR.NGNDNENNRK.......................
F8VQ58_MOUSE/254-314             ....RREPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQP.GEG..NSTK.AEEG.DR.NGDGSDNNRK.......................
Q6JP77_RAT/293-353               ....RKEPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQP.GEG..NSVK.AEEG.DR.NGDGSDNNRK.......................
F7DE14_CALJA/10-52               ...g-NEPEEVKLQNASKQIVQNAILQAMRQVSQESQHRE--.---..----.----.--.----------erisdsr................
H9ERW6_MACMU/21-81               ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GEG..SSVK.TEAA.DR.NGNDNENNRK.......................
F7IC49_CALJA/21-81               ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GEG..SSVK.TEAA.DR.NGNDNENNRK.......................
H0XR10_OTOGA/19-79               ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLDETQNKNKP.GEG..SSVK.TEEA.DR.NGHDSENNRK.......................
G3HT52_CRIGR/8-51                ...g-NEPEEAKLQNASKQIVQNAILRAVQQVSQESL-----.---..----.----.--.----------qrggrpsdcrp............
Q8BVR3_MOUSE/1-60                ...r--EPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQP.GEG..NSTK.AEEG.DR.NGDGSDNNRK.......................
D2I4L4_AILME/6-66                ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKSKP.GDG..SSVK.TQEA.DR.NGTDSDNNRK.......................
G1TZ82_RABIT/22-82               ...g-GEPDDAELLRLSKRLVENAVLKAVQQYLEETQNKKQP.GEG..SSVK.TGEA.ER.NGNDSDHNRK.......................
F7IRN7_CALJA/288-348             ...g-GEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKP.GEG..SSVK.TEAA.DR.NGNDNENNRK.......................
G3VFW8_SARHA/21-82               ...g-REPDDAELVRLSKRLVENAVLKAVQQYLEETQNKARQ.VDG..SPVKpTEPG.HA.DTNNSDNNRK.......................
G1T6I1_RABIT/280-340             ...g-GEPDDAELLRLSKRLVENAVLKAVQQYLEETQNKKQP.GEG..SSVK.TGEA.ER.NGNDSDHNRK.......................
G5C774_HETGA/235-295             ...g-AEPDDVELVRLSKRLVENAVLKAVQQYLEETQNKKQP.GEG..SSVK.AEEA.DG.SGNGSDNNRK.......................
H0ZN63_TAEGU/215-276             ...a-AEPDDAELVSLSKRLVENAVLKAVQQYLEETQNKSRQ.TDG..SPAK.TEEAaSS.NKNESDND--ns.....................
#=GC seq_cons                    ...G.uEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKp+P.G-G..SSVK.sEtu.Dp.NGsss-NNRK.......................
//
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