GenomeNet

Database: Pfam
Entry: ATG19_autophagy
LinkDB: ATG19_autophagy
Original site: ATG19_autophagy 
#=GF ID   ATG19_autophagy
#=GF AC   PF12744.5
#=GF DE   Autophagy protein Atg19, Atg8-binding
#=GF AU   Wood V, Coggill P
#=GF SE   Wood V
#=GF GA   25.00 25.00;
#=GF TC   33.50 25.80;
#=GF NC   21.50 21.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   16247502
#=GF RT   Autophagy: molecular machinery for self-eating.
#=GF RA   Yorimitsu T, Klionsky DJ;
#=GF RL   Cell Death Differ. 2005;12:1542-1552.
#=GF RN   [2]
#=GF RM   11430817
#=GF RT   Cvt19 is a receptor for the cytoplasm-to-vacuole targeting
#=GF RT   pathway.
#=GF RA   Scott SV, Guan J, Hutchins MU, Kim J, Klionsky DJ;
#=GF RL   Mol Cell. 2001;7:1131-1141.
#=GF RN   [3]
#=GF RM   17192412
#=GF RT   Atg19 mediates a dual interaction cargo sorting mechanism in
#=GF RT   selective autophagy.
#=GF RA   Chang CY, Huang WP;
#=GF RL   Mol Biol Cell. 2007;18:919-929.
#=GF RN   [4]
#=GF RM   19236009
#=GF RT   ATG systems from the protein structural point of view.
#=GF RA   Noda NN, Ohsumi Y, Inagaki F;
#=GF RL   Chem Rev. 2009;109:1587-1598.
#=GF DR   INTERPRO; IPR024543;
#=GF CC   Autophagy is generally known as a process involved in the
#=GF CC   degradation of bulk cytoplasmic components that are
#=GF CC   non-specifically sequestered into an autophagosome, where they
#=GF CC   are sequestered into double-membrane vesicles and delivered to
#=GF CC   the degradative organelle, the lysosome/vacuole, for breakdown
#=GF CC   and eventual recycling of the resulting macromolecules. In
#=GF CC   contrast to autophagy, however, the Cvt pathway is a highly
#=GF CC   selective process that involves the sequestration of at least
#=GF CC   two specific cargos that are resident vacuolar hydrolases,
#=GF CC   aminopeptidase I (Ape1) and alpha-mannosidase (Ams1). These
#=GF CC   proteins are sequestered within a double-membrane vesicle,
#=GF CC   termed a Cvt vesicle. The Cvt vesicle is fairly consistent in
#=GF CC   size, and is much smaller than the autophagosome, being 140-160
#=GF CC   nm in diameter. The prApe1 is sequestered within either Cvt
#=GF CC   vesicles or autophagosomes, depending on the nutrient
#=GF CC   conditions, and delivered to the vacuole. Autophagy and the Cvt
#=GF CC   pathway are topologically and mechanistically similar and share
#=GF CC   most of the same machinery. The Ape1 complex is ultimately
#=GF CC   enwrapped within either Cvt vesicles or autophagosomes at the
#=GF CC   perivacuolar PAS. The receptor protein Atg19 binds to the Ape1
#=GF CC   complex through the prApe1 propeptide to form the Cvt complex in
#=GF CC   the cytosol. In the absence of Atg19, prApe1 can form an Ape1
#=GF CC   complex, but does not localise at the PAS. Atg19 is a peripheral
#=GF CC   membrane protein with differing binding sites for both Ape1 and
#=GF CC   Ams1. The Atg8-binding region in the yeast proteins is this very
#=GF CC   C-terminal residues [3].
#=GF SQ   28
#=GS I2H5K3_TETBL/243-350      AC I2H5K3.1
#=GS J8PWV8_SACAR/163-407      AC J8PWV8.1
#=GS E7Q926_YEASB/163-412      AC E7Q926.1
#=GS C5DNC2_LACTC/272-507      AC C5DNC2.1
#=GS K0KQT3_WICCF/270-560      AC K0KQT3.1
#=GS G8BMN5_TETPH/141-398      AC G8BMN5.1
#=GS J7RRG9_KAZNA/175-411      AC J7RRG9.1
#=GS C5DR64_ZYGRC/271-463      AC C5DR64.1
#=GS G0W3W6_NAUDC/170-256      AC G0W3W6.1
#=GS G0V9K5_NAUCC/178-418      AC G0V9K5.1
#=GS E7QKE1_YEASZ/195-415      AC E7QKE1.1
#=GS S6EC66_ZYGB2/268-449      AC S6EC66.1
#=GS ATG34_YEAST/163-412       AC Q12292.1
#=GS ATG34_YEAST/163-412       DR PDB; 2KZK A; 246-348;
#=GS Q6CTN9_KLULA/338-596      AC Q6CTN9.1
#=GS E7M000_YEASV/195-415      AC E7M000.1
#=GS I6NDE5_ERECY/439-722      AC I6NDE5.1
#=GS ATG19_YEAST/195-415       AC P35193.1
#=GS ATG19_YEAST/195-415       DR PDB; 2ZPN H; 1-4;
#=GS ATG19_YEAST/195-415       DR PDB; 2KZB A; 254-367;
#=GS ATG19_YEAST/195-415       DR PDB; 2ZPN E; 1-4;
#=GS ATG19_YEAST/195-415       DR PDB; 2ZPN G; 1-4;
#=GS ATG19_YEAST/195-415       DR PDB; 5AZF D; 1-4;
#=GS ATG19_YEAST/195-415       DR PDB; 2ZPN F; 1-4;
#=GS ATG19_YEAST/195-415       DR PDB; 5AZF C; 1-4;
#=GS E7Q927_YEASB/195-415      AC E7Q927.1
#=GS Q757I4_ASHGO/341-562      AC Q757I4.2
#=GS J5PDA7_SACK1/168-412      AC J5PDA7.1
#=GS A0A0A8L4W5_9SACH/323-592  AC A0A0A8L4W5.1
#=GS E7NN61_YEASO/195-415      AC E7NN61.1
#=GS H2ARX1_KAZAF/267-523      AC H2ARX1.1
#=GS E7QKE0_YEASZ/163-412      AC E7QKE0.2
#=GS G8ZTZ3_TORDC/228-462      AC G8ZTZ3.1
#=GS G0W6A4_NAUDC/703-911      AC G0W6A4.1
#=GS G0W3W6_NAUDC/275-439      AC G0W3W6.1
#=GS E7KI16_YEASA/195-415      AC E7KI16.1
I2H5K3_TETBL/243-350                 ................v-LNIPEEKKELF.DFFSKVQDTSTLSNIQHG...............FET...YQRWLEKVGGKESEIEK....................LLDVHSIMQQELRQETIKTDNK....TNISSTDSERV------------------------..----..--.------.--......----.----------------.--..-------.---.------.........-----..------------..------...-----...........---..--.............----.........--------------.--------------------.--...--------------mknnlkgqlepslkidkqeqqskie......................................................
J8PWV8_SACAR/163-407                 .................CVMISEDNPDLV.EFFSHCKTDVQLEEFYEG...............YKV...YEKLLQKFNGKKKELFSfld.............entpVPEIDSVKQIVSYEEPKEKKRE....TSAPKDQSLRVEVGHQDNSIHFTLCNNTNAIVPGD..CTFE..FF.NSASEV.FS......IR--.--MGPHELGIKGQKEL.CYfpSLPIPLV.DYT.------.........IKVRN..KAGDIIFTGKCD..KSNEIA...LKTPL...........---..--.............STLSig.....giHILQDPCDIFHADAfSSFDESSVMSTPHTGEASDA.DD...SAYTSSRSFTWEEI...............................................................................
E7Q926_YEASB/163-412                 .................CIILPEDKPELI.KFFSKFETSVQLQEVYEG...............YKV...YEKLLQKFDGQKKRMESfln.............entpMSGAEAIKQINISEELKEKGER....LTTPNDPLLHVEVSNEDNSLHFILYNKTNIIIPGN..CTFE..FS.SQISEV.FS......IK--.--MGPHEIGIKGQKEL.WFfpSLPTPLS.NYT.------.........MKVVN..QDGETILVGKCA..DSNEIT...LKSPL...........---..--.............ASFStgsfqtgsfHTLQDPTNVFRADAlSSPDESSIMSTPFLGETDEV.YN...SGSTLSRPFTWEEI...............................................................................
C5DNC2_LACTC/272-507                 .................IIDIPDRNARVF.DFFSKIKTEEQLAQLINH...............YEK...YENLLAQVSGDDAKLQ-....................--EAVALILSPCKTNSLDASIE....TAHEEEDLIDVQMGKRDHVISFKLNNRGPRPVSSG..LRLV..FQ.-YFEPR.NAn....pVKCT.LHMGPHEFQKDSYKTL.NF..NCRGLIE.NFS.LGNPCK.........IDLVD..QDDDVIFTGSSS..GGPNMC...LKQPI...........MFD.iQQ.............SVYS.........EAREVPD----LEA.DSIEDQDIISNTVTNEGSQH.AS...RDD-----------selddy.........................................................................
K0KQT3_WICCF/270-560                 .............pids----KEYESKIV.EFVSKYNDVSKLSKILSK...............IQT...YDHLLSLTDNDEVLLS-....................-TMVESFIESNKNQSIENKS--....-SISKKPNLSIEISQIDQTLIFHLQNKSSLLTPKN..LTLV..MK.IVNKHE.GEgdidnvTKFN.LSIGPHSIYPNGHKRL.YY..NLNGIYEsNFKlFDNKFT.........IELFD..EFNKLFALGICI..NGSGLV..eLNDDL...........--N..VL.............EKLS.........NIDIDDKDEDEIDE.DGSSE-QILQQTNSNSNSNS.NS...DSNS----------sssqfvtpsnstfitdqifqskedlidiesktdslestetadsasttespkssi.........................
G8BMN5_TETPH/141-398                 .................IIDIPESNSKVY.DFFSKIETVSELEEVMNG...............YLK...WKEVEQRDNVCDQEINN....................KNEVVGHPSVRSDISSKPGTDD....LVNENQVVLAVEITKSDYLIEFNVIHEGEKDLPSD..LRLA..YH.DES---.--......IKINdLPLGKHPLKAGRNKTI.KC..NTFNLLN.TTT.GGVTSSnnhttrqnyIYIYD..PSDDSVQYIANI..ATPQTKvylEKAPMl.........sAHN.lQKye.........mlSSPS.........LLKEQNN---NTQS.KSEDDNDIISTTVTNTTLSH.NP...RNTKSTNSRRISDW...............................................................................
J7RRG9_KAZNA/175-411                 .................VIEVSKKNNDLF.EFFNNILTEDQLKDLKHG...............FEK...YTQWISLYNNDEGKLE-....................-EHLKTLQDFSTFFSTKDNSDF....VKYP----ISLRIFPKELNICFELQNSFGVAVPKG..LALMiyYR.DGTLDK.TSt...ykVDIS.HGVGPH-----LTKTF.RR..FKREFGP.EFS.VGNVTR.........VQIIS..DRSQILYTGHQD..AFAEES...DPQSR...........VFN..FTvv.........ddIAFA.........ENNNDND----TAS.YKDNDNDIISTSISNTANDD.DN...HTV-----------tedadfnd.......................................................................
C5DR64_ZYGRC/271-463                 cahqakaassekprsrh------------.------------------...............---...-----------------....................----------------------....----EFASLEITVSHRDDLLTFDIYNNGRRALPGD..CTLV..LAtCDSSTS.GS.....rPTVE.SYLGPHELRPGNRKLF.HK..K----IS.RGS.VIECAR.........IDILDgkNKEEVLYTGSSS..WLLDTSi.kLKPPR...........-LS..KS.............PSPSptat.ltpsAAPEDQSSCKPLSS.LAKEDEGVISSSMTNDEYSLcSD...SGS-----------dtnweey........................................................................
G0W3W6_NAUDC/170-256                 ................f-LDIPIGNKNLI.SFFQNLKSEDDLEKLVDE...............YEL...YQDLKKQYDGHMG-IE-....................MLLDEALERRRFETESKDSRNK....TQLTTQK----------------------------..----..--.------.--......----.----------------.--..-------.---.------.........-----..------------..------...-----...........---..--.............----.........--------------.--------------------.--...--------------mdevlaktae.....................................................................
G0V9K5_NAUCC/178-418                 ......yvkndlyqkin------------.----ELLSKTKINDIIHG...............YEK...YTEWIGLCQDNEDEVRKi..................lTNNNEETATIQVDDEPKNSFINdatsLSASMVPVITMNYQIKDFHVEFTLHNCGTSTLSGG..LNFV..FQ.YQTDSG.NN.....iIEHQ.IDMGPHDLKPDCKKIL.KF..MSLNMIN.TNL.--EILS.........VNVVG..IDGRVIYVGKKDaeKNNQFN...LTHPIls......aehL--..-Etne.......effSVYS........fHQKQEPS-------.EPVDTTDVISTTITNDNA--.--...--------------tkftweeyd......................................................................
E7QKE1_YEASZ/195-415                 .................TIDIPEDRPELV.NFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNERSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FT.DAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQASQEPFYSFQIDTlPELDDSSIISTSISLSYD--.--...-GDDNEKALTWEEL...............................................................................
S6EC66_ZYGB2/268-449                 .....rasnprrerrrr------------.------------------...............---...-----------------....................----------------------....----ELSLLEILVTRRDNLLTFTVHNIGKCTVPAGsiLRLS..LS.DGSKLP.ST......FSVE.GCLGPHELAPGGKRML.NQ..QIPSSFP.QHL.ASNEPR.........IFLFDgtNNERALYAGSAS..TLFDST..fQLRPL...........---..EF.............ASTS.........QHDCKPL------SpLIKEEEELVSSSNTNDEYSL.CSelsNDSNESNVSNW---edy............................................................................
ATG34_YEAST/163-412                  .................CIILPEDKPELI.KFFSKFETSVQLQEVYEG...............YKV...YEKLLQKFGGQKKRMESfln.............entpMSGAEAIKQINISEELKEKGER....LTTPNDPLLHVEVSNEDNSLHFILYNKTNIIIPGN..CTFE..FS.SQISEV.FS......IK--.--MGPHEIGIKGQKEL.WFfpSLPTPLS.NYT.------.........MKVVN..QDGETILVGKCA..DSNEIT...LKSPL...........---..--.............ASFStgsfqtgsfHTLQDPTNVFRADAlSSPDESSIMSTPFLGETDEV.YN...SGSTLSRPFTWEEI...............................................................................
#=GR ATG34_YEAST/163-412       SS    .................XXXXXXXXXXXX.XXXXXXXXXXXXXXXXXX...............XXX...XXXXXXXXXXXXXXXXXXXX.............XXXXXXXXXXXXXXXXXXXXXXXXXX....XXXX--S--EEEE--BTTB--EEEE--SSS---SS..-EEE..B-.-SSS--.B-......-B--.----SS---SS-EEE-.--SS---S--T.T--.------.........-EEE-..TTS-EEEE----..SSS--B...-----...........---..--.............XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XX...XXXXXXXXXXXXXX...............................................................................
Q6CTN9_KLULA/338-596                 .................IIEVGQQNKAMF.DFFAEIKTESELEKLMQDaiswriakqwygediYEKlerYQNMMQENAQKERE---....................------------NESSDEATMN....TQGSSNPSLRVEMFQKGHLLTFKLFNDGDETIPNG..LKLV..FQ.CEQKGR.VAt....pIKCN.LQVGPDELQPGNYKIL.NF..NYRGTLE.EFS.FEQPCK.........IDLID..VREQVVYTTEQS..TVPGSSvfhLKPPVck......mlpMGD..RR.............NIPC.........NEDEDPDVQYTLTS.PSQSDTDVISSSVTDQEEEE.EE...EEEEEEE-------eeeeent........................................................................
E7M000_YEASV/195-415                 .................TIDIPEDRPELV.NFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNERSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FT.DAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQASQEPFYSFQIDTlPELDDSSIISTSISLSYD--.--...-GDDNEKALTWEEL...............................................................................
I6NDE5_ERECY/439-722                 .................TIEIPPEQSDVY.EVLLKMQNEGTLASVVHE...............AED...YQRIIKRFDTSASEIFErlgryeelllmlpdgnydklKSLIEEHLKCNNKAPISPADSA....MKSPSSSEILVEVCDIDYVVTFKLTNHTDEVLPDN..MKLL..LN.YFPDDG.EA......LKYC.IFMGPHKIAPDESKLL.NL..NHHGSIK.RLF.AEGKYQ.........LDLLD..QNDILLYTTKLT..NEAKVS...MKP--...........---..--.............----.........--------------.--------------------.--...--------------ltretvdgclldfevvdglvnsmeklsasskfsadtlardeghgtdtncdekgnsifkddedddedddddddsnstfnk
ATG19_YEAST/195-415                  .................TIDIPEDRSELV.NFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNERSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FT.DAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQASQEPFYSFQIDTlPELDDSSIISTSISLSYD--.--...-GDDNEKALTWEEL...............................................................................
#=GR ATG19_YEAST/195-415       SS    .................XXXXXXXXXXXX.XXXXXXXXXXXXXXXXXX...............XXX...XXXXXXXXXXXXX----....................---------XXXXXXXXXXXXX....XXXSSXXXEEEEEEEETTEEEEEEEEXSSSXXXSS..XEEX..XX.SSSSSX.XXX....XEE--.--XXSXXXXTTXXEEE.EEXSXXXXXXT.TXX.------.........EEEEX..TTSSEEEEEXXX..SSSXEE...XXXSS...........---..XX.............XXXX........XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--.--...-XXXXXXXXX-EE-...............................................................................
E7Q927_YEASB/195-415                 .................TIDIPEDRSELV.NFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNERSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FT.DAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQAAQEPFYSFQIDTlPELDDSSIISTSISLSYD--.--...-GDDNEKALTWEEL...............................................................................
Q757I4_ASHGO/341-562                 ......cifapdisvaa-----------A.TLFSQVHDVKDLERIASQ...............CAA...YESLVPRFGASAEELE-....................-----------RKLSSLPPK--....-ATEDEFGISVTVSRVDFALTFRLRNYTTDAIPSS..SSLV..FS.HHPVGG.SS.....hTR-T.MSIGPHELPPGSSKQL.NI..CYPHQT-.--S.DGDPYS.........LSLVS..PAGTALYSGKAS..SMPADI..lLACPGgtpassaafnaM--..--.............----.........--------------.--------------------.--...--------------ytnqssasvpapvvnapfrqsnspvmpsdeeydllsdsdi.......................................
J5PDA7_SACK1/168-412                 ................y-VVLPEDKPELV.EFFSHLKTSEQLQEIYNG...............YRV...YETLLQKFDGQKEKMHSflh.............egtsVPEGESMEQIALFEEPKEKKEA....LATPDDRSLRVDVNHEDNSLHFILYNNADLIVPGN..CTFE..FS.SSASKV.YS......IK--.--MGPHEIGPKGQKEL.WYfpSLSAPLV.DYT.------.........VKIIN..QNGDVIFIGKCT..ESNEVT...LKSAL...........---..--.............SSFStg.....sfHTLQDPNNVFRADAlSSFDESSVMSSPFPNEIDEI.YD...SGSTLNRPFTWEEI...............................................................................
A0A0A8L4W5_9SACH/323-592             ................v-VKVGLQNRQVIsDFFSEIKTESQLEQLMQDaiswriakqwygediYEKlekYECLMKENAKKECMMKE....................----VADKEHA-SGHSDVSTTE....VKKPSNSSLRVEMFQKGHLLTFKLFNDGDETIPNG..LRLV..FQ.CEQKGR.VSt....pIKCN.LQVGPDELQPGNYKIL.NF..NYRYSLE.QFS.FEHPCK.........IDLID..TREQVVYTTDGN..THCGSSifyLKPPTlk......anpIPS..FR.............DVPC........nEEHEGSDGQYAPAN.SSHSDTDVISSSVTDQEDEE.DN...DEEQ----------daefadqen......................................................................
E7NN61_YEASO/195-415                 .................TIDIPEDRSELV.NFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNERSLQITMNQRDNSLYFQLFNNXNSVLAGN..CKLK..FT.DAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQAAQEPFYSFQIDTlPELDDSSIISTSISLSYD--.--...-GDDNEKALTWEEL...............................................................................
H2ARX1_KAZAF/267-523                 ................f-IDIDPKNRRLF.EYFSKIASEADLEKLLSN...............SQK...YEGLLQRFDNDETLLL-....................-SELSHLSLNNSDTSSIKHEEP....TE--MGIPFELKVYEKDLNVCFELSNGTDTYFSEN..LYLL..IH.YISSEN.EI......WKTK.IDI-CHGIGPKSKRIFtKFksFFEKKGG.DFS.IEDFGF.........FEIKD..GADRLLFSTQGS..KLVPCN...NGTDL...........MFHlvAKynnlteinlrkleNFKS.........EETIKLKEAFTYDN.ENVESDDVISTTITNDVGFE.NN...DSD-----------nefeeydfl......................................................................
E7QKE0_YEASZ/163-412                 .................CIILPEDKPELI.KFFSKFETSVQLQEVYEG...............YKV...YEKLLQKFDGQKKRMESfln.............entpMSGAEAIKQINISEELKEKGER....LTTPNDPLLHVEVSNKDNSLHFILYNKTNIIIPGN..CTFE..FS.SQISEV.FS......IK--.--MGPHEIGIKGQKEL.WFfpSLPTPLS.NYT.------.........MKVVN..QDGDTILVGKCA..DSNEIT...LKSPL...........---..--.............ASFStgsfqtgsfHTLQDPTNVFRADAlSSPDESSIMSTPFLGETDEV.YN...SGSTLSRPFTWEEI...............................................................................
G8ZTZ3_TORDC/228-462                 .................VIDIADDRKDLF.DLFSKME---NLEEIVHG...............FRL...YKKWTEKLSEEKIE---....................--------GILSGEEFSAKNRR....FEVAKPGKLEVELKKKDKAIIFQMRNTGASTVAGG..LTLV..YS.TFKEDD.NLda..snVTCE.LPMGPHELLPGNSKML.KF..NYFGVLS.DIS.METKSQ.........IALVD..SEKNFIFKGTNS..GRAGSHfilNSTGL...........ASD.gIA.............GDLP.........LLNRRDS----LQLlEKDDSDSVISSTVTNDNETL.HS...VSD--QETS-----nwdey..........................................................................
G0W6A4_NAUDC/703-911                 .............letd--------DETH.DFISTLKTSEDLKKVVNG...............YPK...FKEWRYIGGKDESEIDEr..................fSSKDNMIAQVSINHELENIKKP....EEFLNSTALEVTMERRYKDIKFTLTNRGKSDLPGN..SKFV..VQ.YSIEHHgVAh....vADVT.LDMGPHKLLIGSKKHL.LW..SPPCPIH.NGI.--VVDV.........VELST..-EDGFVFYSGKV..HDNNFE...LSTPA...........---..--.............----.........--------------.--------------------.--...--------------lsyehlevneqyynslekrkqvnl.......................................................
G0W3W6_NAUDC/275-439                 .................TIKIPKSDGFLN.EFYSKITTTEKLQDLAIG...............YNW...YKEWIQGCDNNEHLVSS....................----------A----IYQGKEY....MKGKMQCEVSIIVQRNETTWDVTLENISDDPLPKG..MKLV..IE.SYESPK.QKr...pvVVLS.TNIG------------.--..-------.---.------.........-----..------------..------...-----...........---..--.............----.........--------------.--------------------.--...--------------gfppshadelelgptknlnedlrkylrsvikfvtnegevvystvfee................................
E7KI16_YEASA/195-415                 .................TIDIPEDRPELV.NFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNERSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FT.DAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEG.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQASQEPFYSFQIDTlPELDDSSIISTSISLSYD--.--...-GDDNEKALTWEEL...............................................................................
#=GC SS_cons                         .................XXXXXXXXXXXX.XXXXXXXXXXXXXXXXXX...............XXX...XXXXXXXXXXXXX----....................---------XXXXXXXXXXXXX....XXXSSXSXEEEEEEEETTEEEEEEEEXSSSXXXSS..XEEE..BX.SSSSSX.BXX....XEE--.--XXSSXXXTTXEEEE.EESSXXXSXXT.TXX.------.........EEEEX..TTSSEEEEEXXX..SSSXEE...XXXSS...........---..XX.............XXXX........XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--.--...-XXXXXXXXX-EE-...............................................................................
#=GC seq_cons                        .................hIplsccpscLh.cFFoclcTsppLpclhpt...............Ycp...YccLhpchssccp.h...............................hs.spp.ccsp.p....hpsssptsLplphsp+DpslpFpLhNpsspslsus..hpLh..ap.stsscs.ss......lc.....hGPHElt.tp.Kph.pa...h.s.hs.sho................lclhs..ptscllahGcts..sssths...L+sPh...............................ss.S.........pt.pcs.....hss..p.--ssllSooho.p.s.........ss..........................................................................................
//
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