GenomeNet

Database: Pfam
Entry: ATG19_autophagy
LinkDB: ATG19_autophagy
Original site: ATG19_autophagy 
#=GF ID   ATG19_autophagy
#=GF AC   PF12744.3
#=GF DE   Autophagy protein Atg19, Atg8-binding
#=GF AU   Wood V, Coggill P
#=GF SE   Wood V
#=GF GA   25.00 25.00;
#=GF TC   32.80 25.30;
#=GF NC   24.70 21.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   16247502
#=GF RT   Autophagy: molecular machinery for self-eating.
#=GF RA   Yorimitsu T, Klionsky DJ;
#=GF RL   Cell Death Differ. 2005;12:1542-1552.
#=GF RN   [2]
#=GF RM   11430817
#=GF RT   Cvt19 is a receptor for the cytoplasm-to-vacuole targeting
#=GF RT   pathway.
#=GF RA   Scott SV, Guan J, Hutchins MU, Kim J, Klionsky DJ;
#=GF RL   Mol Cell. 2001;7:1131-1141.
#=GF RN   [3]
#=GF RM   17192412
#=GF RT   Atg19 mediates a dual interaction cargo sorting mechanism in
#=GF RT   selective autophagy.
#=GF RA   Chang CY, Huang WP;
#=GF RL   Mol Biol Cell. 2007;18:919-929.
#=GF RN   [4]
#=GF RM   19236009
#=GF RT   ATG systems from the protein structural point of view.
#=GF RA   Noda NN, Ohsumi Y, Inagaki F;
#=GF RL   Chem Rev. 2009;109:1587-1598.
#=GF DR   INTERPRO; IPR024543;
#=GF CC   Autophagy is generally known as a process involved in the
#=GF CC   degradation of bulk cytoplasmic components that are
#=GF CC   non-specifically sequestered into an autophagosome, where they
#=GF CC   are sequestered into double-membrane vesicles and delivered to
#=GF CC   the degradative organelle, the lysosome/vacuole, for breakdown
#=GF CC   and eventual recycling of the resulting macromolecules. In
#=GF CC   contrast to autophagy, however, the Cvt pathway is a highly
#=GF CC   selective process that involves the sequestration of at least
#=GF CC   two specific cargos that are resident vacuolar hydrolases,
#=GF CC   aminopeptidase I (Ape1) and alpha-mannosidase (Ams1). These
#=GF CC   proteins are sequestered within a double-membrane vesicle,
#=GF CC   termed a Cvt vesicle. The Cvt vesicle is fairly consistent in
#=GF CC   size, and is much smaller than the autophagosome, being 140-160
#=GF CC   nm in diameter. The prApe1 is sequestered within either Cvt
#=GF CC   vesicles or autophagosomes, depending on the nutrient
#=GF CC   conditions, and delivered to the vacuole. Autophagy and the Cvt
#=GF CC   pathway are topologically and mechanistically similar and share
#=GF CC   most of the same machinery. The Ape1 complex is ultimately
#=GF CC   enwrapped within either Cvt vesicles or autophagosomes at the
#=GF CC   perivacuolar PAS. The receptor protein Atg19 binds to the Ape1
#=GF CC   complex through the prApe1 propeptide to form the Cvt complex in
#=GF CC   the cytosol. In the absence of Atg19, prApe1 can form an Ape1
#=GF CC   complex, but does not localise at the PAS. Atg19 is a peripheral
#=GF CC   membrane protein with differing binding sites for both Ape1 and
#=GF CC   Ams1. The Atg8-binding region in the yeast proteins is this very
#=GF CC   C-terminal residues [3].
#=GF SQ   57
#=GS A6ZNC7_YEAS7/163-412      AC A6ZNC7.1
#=GS H0H0S4_SACCK/194-421      AC H0H0S4.1
#=GS G8BMN5_TETPH/141-398      AC G8BMN5.1
#=GS A0A024XKC8_YEASX/195-415  AC A0A024XKC8.1
#=GS A0A023ZGM2_YEASX/163-412  AC A0A023ZGM2.1
#=GS E7QKE1_YEASZ/195-415      AC E7QKE1.1
#=GS G2WMF3_YEASK/195-415      AC G2WMF3.1
#=GS S6EC66_ZYGB2/268-449      AC S6EC66.1
#=GS ATG34_YEAST/163-412       AC Q12292.1
#=GS ATG34_YEAST/163-412       DR PDB; 2KZK A; 246-348;
#=GS W7R4K4_YEASX/195-415      AC W7R4K4.1
#=GS C5DNC2_LACTC/272-510      AC C5DNC2.1
#=GS G2WMF2_YEASK/163-412      AC G2WMF2.1
#=GS B3LIY0_YEAS1/163-412      AC B3LIY0.1
#=GS ATG19_YEAS7/195-415       AC A6ZNC8.1
#=GS I6NDE5_ERECY/439-722      AC I6NDE5.1
#=GS A0A024XVE7_YEASX/195-415  AC A0A024XVE7.1
#=GS Q6CTN9_KLULA/338-615      AC Q6CTN9.1
#=GS N1NX67_YEASC/195-415      AC N1NX67.1
#=GS C8ZHN4_YEAS8/163-412      AC C8ZHN4.1
#=GS Q757I4_ASHGO/341-562      AC Q757I4.2
#=GS J5PDA7_SACK1/168-412      AC J5PDA7.1
#=GS E7NN61_YEASO/195-415      AC E7NN61.1
#=GS G8ZTZ3_TORDC/228-462      AC G8ZTZ3.1
#=GS A0A023ZG59_YEASX/195-415  AC A0A023ZG59.1
#=GS G0W3W6_NAUDC/170-258      AC G0W3W6.1
#=GS W0VXJ9_ZYGBA/268-449      AC W0VXJ9.1
#=GS J8PWV8_SACAR/163-407      AC J8PWV8.1
#=GS I2H5K3_TETBL/243-350      AC I2H5K3.1
#=GS M9N0X5_ASHG1/341-562      AC M9N0X5.1
#=GS E7Q926_YEASB/163-412      AC E7Q926.1
#=GS C7GK47_YEAS2/163-412      AC C7GK47.1
#=GS E7QKE0_YEASZ/163-412      AC E7QKE0.1
#=GS W7PCJ0_YEASX/195-415      AC W7PCJ0.1
#=GS K0KQT3_WICCF/270-560      AC K0KQT3.1
#=GS R9XDZ6_ASHAC/360-549      AC R9XDZ6.1
#=GS C8ZHN6_YEAS8/195-415      AC C8ZHN6.1
#=GS J7RRG9_KAZNA/175-412      AC J7RRG9.1
#=GS H0GN45_SACCK/195-415      AC H0GN45.1
#=GS B3LIY1_YEAS1/195-415      AC B3LIY1.1
#=GS G0V9K5_NAUCC/148-419      AC G0V9K5.1
#=GS W0T8D6_KLUMA/312-565      AC W0T8D6.1
#=GS B5VRH2_YEAS6/195-415      AC B5VRH2.1
#=GS C5DR64_ZYGRC/273-463      AC C5DR64.1
#=GS E7M000_YEASV/195-415      AC E7M000.1
#=GS A0A024XH97_YEASX/163-412  AC A0A024XH97.1
#=GS W0VSE8_ZYGBA/225-449      AC W0VSE8.1
#=GS ATG19_YEAST/195-415       AC P35193.1
#=GS ATG19_YEAST/195-415       DR PDB; 2ZPN H; 1-4;
#=GS ATG19_YEAST/195-415       DR PDB; 2KZB A; 254-367;
#=GS ATG19_YEAST/195-415       DR PDB; 2ZPN E; 1-4;
#=GS ATG19_YEAST/195-415       DR PDB; 2ZPN G; 1-4;
#=GS ATG19_YEAST/195-415       DR PDB; 2ZPN F; 1-4;
#=GS C7GK46_YEAS2/195-415      AC C7GK46.1
#=GS E7Q927_YEASB/195-415      AC E7Q927.1
#=GS H2ARX1_KAZAF/267-523      AC H2ARX1.1
#=GS B5VRH1_YEAS6/163-412      AC B5VRH1.1
#=GS H0H0S3_SACCK/80-324       AC H0H0S3.1
#=GS G0W6A4_NAUDC/703-911      AC G0W6A4.1
#=GS G0W3W6_NAUDC/275-439      AC G0W3W6.1
#=GS E7KI16_YEASA/195-415      AC E7KI16.1
#=GS A0A024XW40_YEASX/163-412  AC A0A024XW40.1
#=GS N1NZ43_YEASC/163-412      AC N1NZ43.1
A6ZNC7_YEAS7/163-412                 .............................................................CIILPEDKPELIKFFSKFETSVQLQEVYEG...............YKV...YEKLLQKFDGQKKRMESfln.............entpMSGAEAIKQINISEELKEKGER....LTTPND..PLLHVEVSNEDNSLHFILYNKTNIIIPGN..CTFE..FSSQISEV.FS......IK--.--MGPHEIGIKGQKEL.WFfpSLPTPLS.NYT.------.........MKVVN..QDGETILVGKCA..DSNEIT...LKSPL...........---..--.............ASFStgsfqtgsfHTLQDPTNVFRADAlSSPDESSIVSTPFLGETDE...VYNS...GSTLSRPFTWEEI...............................................................................
H0H0S4_SACCK/194-421                 .............................................................TIDIPEDNPELVSFFTELKTVKQLENVFQR...............YHD...YESLLAKCCAETET--E....................TTKDLLKEEIAVSKNA-EVS--....-ERLDD..RSLQVTVNYRDGSLYFHLYNNTNSVLAGN..CKLK..FTNDNDKP.TTr....iIE--.--MGPHEIGIKEHKEL.RYfpYTPELIT.SST.------.........IAIEN..EYEEVIFVGKHG..RSPRVS...LKPPS...........---..RL.............SVES........lQASQDHFYDFRIDSlPELDDSSIISTSISLSCE-...----...DDDCGKAMTWEEL...............................................................................
G8BMN5_TETPH/141-398                 .............................................................IIDIPESNSKVYDFFSKIETVSELEEVMNG...............YLK...WKEVEQRDNVCDQEINN....................KNEVVGHPSVRSDISSKPGTDD....LVNENQ..VVLAVEITKSDYLIEFNVIHEGEKDLPSD..LRLA..YHDES---.--......IKINdLPLGKHPLKAGRNKTI.KC..NTFNLLN.TTT.GGVTSSnnhttrqnyIYIYD..PSDDSVQYIANI..ATPQTKvylEKAPMl.........sAHN.lQKye.........mlSSPS.........LLKEQNN---NTQS.KSEDDNDIISTTVTNTTLS...HNPR...NTKSTNSRRISDW...............................................................................
A0A024XKC8_YEASX/195-415             .............................................................TIDIPEDRPELVNFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNE..RSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FTDAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQASQEPFYSFQIDTlPELDDSSIISTSISLSYD-...----...GDDNEKALTWEEL...............................................................................
A0A023ZGM2_YEASX/163-412             .............................................................CIILPEDKPELIKFFSKFETSVQLQEVYEG...............YKV...YEKLLQKFDGQKKRMESfln.............entpMSGAEAIKQINISEELKEKGER....LTTPND..PLLHVEVSNKDNSLHFILYNKTNIIIPGN..CTFE..FSSQISEV.FS......IK--.--MGPHEIGIKGQKEL.WFfpSLPTPLS.NYT.------.........MKVVN..QDGDTILVGKCA..DSNEIT...LKSPL...........---..--.............ASFStgsfqtgsfHTLQDPTNVFRADAlSSPDESSIMSTPFLGETDE...VYNS...GSTLSRPFTWEEI...............................................................................
E7QKE1_YEASZ/195-415                 .............................................................TIDIPEDRPELVNFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNE..RSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FTDAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQASQEPFYSFQIDTlPELDDSSIISTSISLSYD-...----...GDDNEKALTWEEL...............................................................................
G2WMF3_YEASK/195-415                 .............................................................TIDIPEDRSELVNFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNE..RSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FTDAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQASQEPFYSFQIDTlPELDDSSIISTSISLSYD-...----...GDDNEKALTWEEL...............................................................................
S6EC66_ZYGB2/268-449                 .................................................rasnprrerrrr------------------------------...............---...-----------------....................----------------------....----EL..SLLEILVTRRDNLLTFTVHNIGKCTVPAGsiLRLS..LSDGSKLP.ST......FSVE.GCLGPHELAPGGKRML.NQ..QIPSSFP.QHL.ASNEPR.........IFLFDgtNNERALYAGSAS..TLFDST..fQLRPL...........---..EF.............ASTS.........QHDCKPL------SpLIKEEEELVSSSNTNDEYSlcsELSN...DSNESNVSNWED-y..............................................................................
ATG34_YEAST/163-412                  .............................................................CIILPEDKPELIKFFSKFETSVQLQEVYEG...............YKV...YEKLLQKFGGQKKRMESfln.............entpMSGAEAIKQINISEELKEKGER....LTTPND..PLLHVEVSNEDNSLHFILYNKTNIIIPGN..CTFE..FSSQISEV.FS......IK--.--MGPHEIGIKGQKEL.WFfpSLPTPLS.NYT.------.........MKVVN..QDGETILVGKCA..DSNEIT...LKSPL...........---..--.............ASFStgsfqtgsfHTLQDPTNVFRADAlSSPDESSIMSTPFLGETDE...VYNS...GSTLSRPFTWEEI...............................................................................
#=GR ATG34_YEAST/163-412       SS    .............................................................XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...............XXX...XXXXXXXXXXXXXXXXXXXX.............XXXXXXXXXXXXXXXXXXXXXXXXXX....XXXX--..S--EEEE--BTTB--EEEE--SSS---SS..-EEE..B--SSS--.B-......-B--.----SS---SS-EEE-.--SS---S--T.T--.------.........-EEE-..TTS-EEEE----..SSS--B...-----...........---..--.............XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXX...XXXXXXXXXXXXX...............................................................................
W7R4K4_YEASX/195-415                 .............................................................TIDIPEDRPELVNFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNE..RSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FTDAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQASQEPFYSFQIDTlPELDDSSIISTSISLSYD-...----...GDDNEKALTWEEL...............................................................................
C5DNC2_LACTC/272-510                 .............................................................IIDIPDRNARVFDFFSKIKTEEQLAQLINH...............YEK...YENLLAQVSGDDAKLQE....................AVALILSP---CKTNSLDASIE....TAHEEE..DLIDVQMGKRDHVISFKLNNRGPRPVSSG..LRLV..FQYFEPR-.NAn....pVKCT.LHMGPHEFQKDSYKTL.NF..NCRGLIE.NFS.LGNPCK.........IDLVD..QDDDVIFTGSSS..GGPNMC...LKQPI...........MFD.iQQ.............SVYS.........EAREVPD----LEA.DSIEDQDIISNTVTNEGSQ...HASR...DDSELD-------dydfl..........................................................................
G2WMF2_YEASK/163-412                 .............................................................CIILPEDKPELIKFFSKFETSVQLQEVYEG...............YKV...YEKLLQKFDGQKKRMESfln.............entpMSGAEAIKQINISEELKEKGER....LTTPND..PLLHVEVSNEDNSLHFILYNKTNIIIPGN..CTFE..FSSQISEV.FS......IK--.--MGPHEIGIKGQKEL.WFfpSLPTPLS.NYT.------.........MKVVN..QDGETILVGKCA..DSNEIT...LKSPL...........---..--.............ASFStgsfqtgsfHTLQDPTNVFRADAlSSPDESSIMSTPFLGETDE...VYNS...GSTLSRPFTWEEI...............................................................................
B3LIY0_YEAS1/163-412                 .............................................................CIILPEDKPELIKFFSKFETSVQLQEVYEG...............YKV...YEKLLQKFDGQKKRMESfln.............entpMSGAEAIKQINISEELKEKGER....LTTPND..PLLHVEVSNKDNSLHFILYNKTNIIIPGN..CTFE..FSSQISEV.FS......IK--.--MGPHEIGIKGQKEL.WFfpSLPTPLS.NYT.------.........MKVVN..QDGDTILVGKCA..DSNEIT...LKSPL...........---..--.............ASFStgsfqtgsfHTLQDPTNVFRADAlSSPDESSIMSTPFLGETDE...VYNS...GSTLSRPFTWEEI...............................................................................
ATG19_YEAS7/195-415                  .............................................................TIDIPEDRSELVNFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNE..RSLQITMDQRDNSLYFQLFNNTNSVLAGN..CKLK..FTDAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQASQEPFYSFQIDTlPELDDSSIISTSISLSYD-...----...GDDNEKALTWEEL...............................................................................
I6NDE5_ERECY/439-722                 .............................................................TIEIPPEQSDVYEVLLKMQNEGTLASVVHE...............AED...YQRIIKRFDTSASEIFErlgryeelllmlpdgnydklKSLIEEHLKCNNKAPISPADSA....MKSPSS..SEILVEVCDIDYVVTFKLTNHTDEVLPDN..MKLL..LNYFPDDG.EA......LKYC.IFMGPHKIAPDESKLL.NL..NHHGSIK.RLF.AEGKYQ.........LDLLD..QNDILLYTTKLT..NEAKVS...MKP--...........---..--.............----.........--------------.-------------------...----...-------------ltretvdgclldfevvdglvnsmeklsasskfsadtlardeghgtdtncdekgnsifkddedddedddddddsnstfnk
A0A024XVE7_YEASX/195-415             .............................................................TIDIPEDRPELVNFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNE..RSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FTDAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQASQEPFYSFQIDTlPELDDSSIISTSISLSYD-...----...GDDNEKALTWEEL...............................................................................
Q6CTN9_KLULA/338-615                 .............................................................IIEVGQQNKAMFDFFAEIKTESELEKLMQDaiswriakqwygediYEKlerYQNMMQENAQKERE---....................------------NESSDEATMN....TQGSSN..PSLRVEMFQKGHLLTFKLFNDGDETIPNG..LKLV..FQCEQKGR.VAt....pIKCN.LQVGPDELQPGNYKIL.NF..NYRGTLE.EFS.FEQPCK.........IDLID..VREQVVYTTEQS..TVPGSSvfhLKPPVck......mlpMGD..RR.............NIPC.........NEDEDPDVQYTLTS.PSQSDTDVISSSVTDQEEE...EEEE...EEEEEE-------eeeeentaqadnenndlvyveslsee.....................................................
N1NX67_YEASC/195-415                 .............................................................TIDIPEDRSELVNFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNE..RSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FTDAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQASQEPFYSFQIDTlPELDDSSIISTSISLSYD-...----...GDDNEKALTWEEL...............................................................................
C8ZHN4_YEAS8/163-412                 .............................................................CIILPEDKPELIKFFSKFETSVQLQEVYEG...............YKV...YEKLLQKFDGQKKRMESfln.............entpMSGAEAIKQINISEELKEKGER....LTTPND..PLLHVEVSNKDNSLHFILYNKTNIIIPGN..CTFE..FSSQISEV.FS......IK--.--MGPHEIGIKGQKEL.WFfpSLPTPLS.NYT.------.........MKVVN..QDGDTILVGKCA..DSNEIT...LKSPL...........---..--.............ASFStgsfqtgsfHTLQDPTNVFRADAlSSPDESSIMSTPFLGETDE...VYNS...GSTLSRPFTWEEI...............................................................................
Q757I4_ASHGO/341-562                 ..................................................cifapdisvaa-----------ATLFSQVHDVKDLERIASQ...............CAA...YESLVPRFGASAEELE-....................-----------RKLSSLPPK--....-ATEDE..FGISVTVSRVDFALTFRLRNYTTDAIPSS..SSLV..FSHHPVGG.SS.....hTR-T.MSIGPHELPPGSSKQL.NI..CYPHQT-.--S.DGDPYS.........LSLVS..PAGTALYSGKAS..SMPADI..lLACPGgtpassaafnaM--..--.............----.........--------------.-------------------...----...-------------ytnqssasvpapvvnapfrqsnspvmpsdeeydllsdsdi.......................................
J5PDA7_SACK1/168-412                 ............................................................y-VVLPEDKPELVEFFSHLKTSEQLQEIYNG...............YRV...YETLLQKFDGQKEKMHSflh.............egtsVPEGESMEQIALFEEPKEKKEA....LATPDD..RSLRVDVNHEDNSLHFILYNNADLIVPGN..CTFE..FSSSASKV.YS......IK--.--MGPHEIGPKGQKEL.WYfpSLSAPLV.DYT.------.........VKIIN..QNGDVIFIGKCT..ESNEVT...LKSAL...........---..--.............SSFStg.....sfHTLQDPNNVFRADAlSSFDESSVMSSPFPNEIDE...IYDS...GSTLNRPFTWEEI...............................................................................
E7NN61_YEASO/195-415                 .............................................................TIDIPEDRSELVNFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNE..RSLQITMNQRDNSLYFQLFNNXNSVLAGN..CKLK..FTDAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQAAQEPFYSFQIDTlPELDDSSIISTSISLSYD-...----...GDDNEKALTWEEL...............................................................................
G8ZTZ3_TORDC/228-462                 .............................................................VIDIADDRKDLFDLFSKME---NLEEIVHG...............FRL...YKKWTEKLSEEKIE---....................--------GILSGEEFSAKNRR....FEVAKP..GKLEVELKKKDKAIIFQMRNTGASTVAGG..LTLV..YSTFKEDD.NLda..snVTCE.LPMGPHELLPGNSKML.KF..NYFGVLS.DIS.METKSQ.........IALVD..SEKNFIFKGTNS..GRAGSHfilNSTGL...........ASD.gIA.............GDLP.........LLNRRDS----LQLlEKDDSDSVISSTVTNDNET...LHSV...SDQETS--NWDE-y..............................................................................
A0A023ZG59_YEASX/195-415             .............................................................TIDIPEDRPELVNFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNE..RSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FTDAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQASQEPFYSFQIDTlPELDDSSIISTSISLSYD-...----...GDDNEKALTWEEL...............................................................................
G0W3W6_NAUDC/170-258                 ............................................................f-LDIPIGNKNLISFFQNLKSEDDLEKLVDE...............YEL...YQDLKKQYDGHMG-I-E....................MLLDEALERRRFETESKDSRNK....TQLTTQ..-----------------------------..----..--------.--......----.----------------.--..-------.---.------.........-----..------------..------...-----...........---..--.............----.........--------------.-------------------...----...-------------kmdevlaktaele..................................................................
W0VXJ9_ZYGBA/268-449                 .................................................rasnprrerrrr------------------------------...............---...-----------------....................----------------------....----EL..SLLEILVTRRDNLLTFTVHNIGKCTVPAGsiLRLS..LSDGSKLP.ST......FSVE.GCLGPHELAPGGKRML.NQ..QIPSSFP.QHL.ASNEPR.........IFLFDgtNNERALYAGSAS..TLFDST..fQLRPL...........---..EF.............ASTS.........QHDCKPL------SpLIKEEEELVSSSNTNDEYSlcsELSN...DSNESNVSNWED-y..............................................................................
J8PWV8_SACAR/163-407                 .............................................................CVMISEDNPDLVEFFSHCKTDVQLEEFYEG...............YKV...YEKLLQKFNGKKKELFSfld.............entpVPEIDSVKQIVSYEEPKEKKRE....TSAPKD..QSLRVEVGHQDNSIHFTLCNNTNAIVPGD..CTFE..FFNSASEV.FS......IR--.--MGPHELGIKGQKEL.CYfpSLPIPLV.DYT.------.........IKVRN..KAGDIIFTGKCD..KSNEIA...LKTPL...........---..--.............STLSig.....giHILQDPCDIFHADAfSSFDESSVMSTPHTGEASD...ADDS...AYTSSRSFTWEEI...............................................................................
I2H5K3_TETBL/243-350                 ............................................................v-LNIPEEKKELFDFFSKVQDTSTLSNIQHG...............FET...YQRWLEKVGGKESEIEKlldvhsi.....mqqelrqeTIKTDNKTNISSTDSERVMKNN....LKGQLE..PSLKID-----------------------..----..--------.--......----.----------------.--..-------.---.------.........-----..------------..------...-----...........---..--.............----.........--------------.-------------------...----...-------------kqeqqskie......................................................................
M9N0X5_ASHG1/341-562                 ...................................................cifapdisva----------AATLFSQVHDVKDLERIASQ...............CAA...YENLVPRFGASAEELE-....................-----------RKLSSLPPK--....-AAEDE..FGISVTVSRVDFALTFRLRNYTTDAIPSS..SSLV..FSHHPVGG.SS.....hTR-T.MSIGPHELPPGSSKQL.NI..CYPHQT-.--S.DGDPYS.........LSLVS..PAGTALYSGKAS..SMPADI..lLACPGgtpassaafnaM--..--.............----.........--------------.-------------------...----...-------------ytnqssasvpapvvnapfrqsnspvmpsdeeydllsdsdi.......................................
E7Q926_YEASB/163-412                 .............................................................CIILPEDKPELIKFFSKFETSVQLQEVYEG...............YKV...YEKLLQKFDGQKKRMESfln.............entpMSGAEAIKQINISEELKEKGER....LTTPND..PLLHVEVSNEDNSLHFILYNKTNIIIPGN..CTFE..FSSQISEV.FS......IK--.--MGPHEIGIKGQKEL.WFfpSLPTPLS.NYT.------.........MKVVN..QDGETILVGKCA..DSNEIT...LKSPL...........---..--.............ASFStgsfqtgsfHTLQDPTNVFRADAlSSPDESSIMSTPFLGETDE...VYNS...GSTLSRPFTWEEI...............................................................................
C7GK47_YEAS2/163-412                 .............................................................CIILPEDKPELIKFFSKFETSVQLQEVYEG...............YKV...YEKLLQKFDGQKKRMESfln.............entpMSGAEAIKQINISEELKEKGER....LTTPND..PLLHVEVSNEDNSLHFILYNKTNIIIPGN..CTFE..FSSQISEV.FS......IK--.--MGPHEIGIKGQKEL.WFfpSLPTPLS.NYT.------.........MKVVN..QDGETILVGKCA..DSNEIT...LKSPL...........---..--.............ASFStgsfqtgsfHTLQDPTNVFRADAlSSPDESSIMSTPFLGETDE...VYNS...GSTLSRPFTWEEI...............................................................................
E7QKE0_YEASZ/163-412                 .............................................................CIILPEDKPELIKFFSKFETSVQLQEVYEG...............YKV...YEKLLQKFDGQKKRMESfln.............entpMSGAEAIKQINISEELKEKGER....LTTPND..PLLHVZVSNKDNSLHFILYNKTNIIIPGN..CTFE..FSSQISEV.FS......IK--.--MGPHEIGIKGQKEL.WFfpSLPTPLS.NYT.------.........MKVVN..QDGDTILVGKCA..DSNEIT...LKSPL...........---..--.............ASFStgsfqtgsfHTLQDPTNVFRADAlSSPDESSIMSTPFLGETDE...VYNS...GSTLSRPFTWEEI...............................................................................
W7PCJ0_YEASX/195-415                 .............................................................TIDIPEDRPELVNFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNE..RSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FTDAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEG.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQASQEPFYSFQIDTlPELDDSSIISTSISLSYD-...----...GDDNEKALTWEEL...............................................................................
K0KQT3_WICCF/270-560                 .........................................................pids----KEYESKIVEFVSKYNDVSKLSKILSK...............IQT...YDHLLSLTDNDEVLLST....................MVESFIES---NKNQSIENKS-....-SISKK..PNLSIEISQIDQTLIFHLQNKSSLLTPKN..LTLV..MKIVNKHE.GEgdidnvTKFN.LSIGPHSIYPNGHKRL.YY..NLNGIYEsNFKlFDNKFT.........IELFD..EFNKLFALGICI..NGSGLV..eLNDDL...........--N..VL.............EKLS.........NIDIDDKDEDEIDE.DGSSE-QILQQTNSNSNSN...SNSD...SNSS---------ssqfvtpsnstfitdqifqskedlidiesktdslestetadsasttespkssi..........................
R9XDZ6_ASHAC/360-549                 cifapdlspaaaalfsqvldvedleriasqcaaleslvprfganaeelarklsslpldasv------------------------------...............---...-----------------....................----------------------....----KQ..PGVSVTVSRVDFALTFRLYNQTADTIPPS..SSLV..FGHHPVGG.SS.....hTR-T.MSIGPHELPPGSSKQL.NI..CYPHHTS.D--.-GDPYS.........LSLVS..PAGTALYSGKAS..SMPAD-...-----...........---..--.............----.........--------------.-------------------...----...-------------illarpgaapaqsttpeaaspkqspvp....................................................
C8ZHN6_YEAS8/195-415                 .............................................................TIDIPEDRPELVNFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNE..RSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FTDAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQASQEPFYSFQIDTlPELDDSSIISTSISLSYD-...----...GDDNEKALTWEEL...............................................................................
J7RRG9_KAZNA/175-412                 .............................................................VIEVSKKNNDLFEFFNNILTEDQLKDLKHG...............FEK...YTQWISLYNNDEGKLEE....................--HLKTLQDFSTFFSTKDNSDF....VKYP--..--ISLRIFPKELNICFELQNSFGVAVPKG..LALMiyYRDGTLDK.TSt...ykVDIS.HGVGPH-----LTKTF.RR..FKREFGP.EFS.VGNVTR.........VQIIS..DRSQILYTGHQD..AFAEES...DPQSR...........VFN..FTvv.........ddIAFA.........ENNNDND----TAS.YKDNDNDIISTSISNTAND...DDNH...TVTE---------dadfndy........................................................................
H0GN45_SACCK/195-415                 .............................................................TIDIPEDRPELVNFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNE..RSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FTDAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQASQEPFYSFQIDTlPELDDSSIISTSISLSYD-...----...GDDNEKALTWEEL...............................................................................
B3LIY1_YEAS1/195-415                 .............................................................TIDIPEDRPELVNFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNE..RSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FTDAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQASQEPFYSFQIDTlPELDDSSIISTSISLSYD-...----...GDDNEKALTWEEL...............................................................................
G0V9K5_NAUCC/148-419                 ....................elsskqlqleysnkvsetvvedrleesnniyvkndlyqkin----------------ELLSKTKINDIIHG...............YEK...YTEWIGLCQDNEDEVRKi..................lTNNNEETATIQVDDEPKNSFINdatsLSASMV..PVITMNYQIKDFHVEFTLHNCGTSTLSGG..LNFV..FQYQTDSG.NN.....iIEHQ.IDMGPHDLKPDCKKIL.KF..MSLNMIN.TNL.--EILS.........VNVVG..IDGRVIYVGKKDaeKNNQFN...LTHPIls......aehL--..-Etne.......effSVYS........fHQKQEPS-------.EPVDTTDVISTTITNDNA-...----...-------------tkftweeydl.....................................................................
W0T8D6_KLUMA/312-565                 .............................................................IIEVGQHNKPMFDFFSKIQSEEELSSLMQDavswriakqwygediYEKlekYETMMKEKVQQEQ----....................---------ADSDAVIDEDSL-....GNDQKN..RSLRVEMSQKGHLLTFKLFNDGDETIPNG..LKLV..FQCEQRDR.VSt....pIKCN.LQMGPNELQPGNYKIL.NF..NYRGTLE.EFS.FDCPCK.........IDLID..VRDQIVYTSEEC..ASPGSSvfyLKPPTc.........eMY-..RRas.........yrDVPC........nEEYEGRDGQYEEPN.AFHSDTDVISTSFTEQEDN...GEE-...-------------avfvdsl........................................................................
B5VRH2_YEAS6/195-415                 .............................................................TIDIPEDRPELVNFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNE..RSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FTDAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQASQEPFYSFQIDTlPELDDSSIISTSISLSYD-...----...GDDNEKALTWEEL...............................................................................
C5DR64_ZYGRC/273-463                 ..............................................hqakaassekprsrh------------------------------...............---...-----------------....................----------------------....----EF..ASLEITVSHRDDLLTFDIYNNGRRALPGD..CTLV..LATCDSST.SGs....rPTVE.SYLGPHELRPGNRKLF.HK..K----IS.RGS.VIECAR.........IDILDgkNKEEVLYTGSSS..WLLDTSi.kLKPPR...........-LS..KS.............PSPSptat.ltpsAAPEDQSSCKPLSS.LAKEDEGVISSSMTNDEYS...LCSD...SGSDTN---WE--ey.............................................................................
E7M000_YEASV/195-415                 .............................................................TIDIPEDRPELVNFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNE..RSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FTDAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQASQEPFYSFQIDTlPELDDSSIISTSISLSYD-...----...GDDNEKALTWEEL...............................................................................
A0A024XH97_YEASX/163-412             .............................................................CIILPEDKPELIKFFSKFETSVQLQEVYEG...............YKV...YEKLLQKFDGQKKRMESfln.............entpMSGAEAIKQINISEELKEKGER....LTTPND..PLLHVEVSNKDNSLHFILYNKTNIIIPGN..CTFE..FSSQISEV.FS......IK--.--MGPHEIGIKGQKEL.WFfpSLPTPLS.NYT.------.........MKVVN..QDGDTILVGKCA..DSNEIT...LKSPL...........---..--.............ASFStgsfqtgsfHTLQDPTNVFRADAlSSPDESSIMSTPFLGETDE...VYNS...GSTLSRPFTWEEI...............................................................................
W0VSE8_ZYGBA/225-449                 ........iadipheqqedvikmfsnadklrevisgyqvycsskkpksrplrasklgrerh------------------------------...............---...-----------------....................----------------------....--RREL..SLLEIFVTRRDNLLTFTVHNVGKCTVPAGsvLRLS..LFHDEKLP.ST......FSIE.GCLGPHELAPGGRRVL.NQ..QISSSFP.RNL.ASNEPR.........IFLFDgtNSEHVLYAGSAS..TLFDSTf.qLRPP-...........---..--.............-EFA.........NSSQHDC---KPLSpLIKEDVEVVSSSNTNDEYS...LCSElsnDSNESNISNW---edy............................................................................
ATG19_YEAST/195-415                  .............................................................TIDIPEDRSELVNFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNE..RSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FTDAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQASQEPFYSFQIDTlPELDDSSIISTSISLSYD-...----...GDDNEKALTWEEL...............................................................................
#=GR ATG19_YEAST/195-415       SS    .............................................................XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...............XXX...XXXXXXXXXXXXX----....................---------XXXXXXXXXXXXX....XXXSSX..XXEEEEEEEETTEEEEEEEEXSSSXXXSS..XEEX..XXSSSSSX.XXX....XEE--.--XXSXXXXTTXXEEE.EEXSXXXXXXT.TXX.------.........EEEEX..TTSSEEEEEXXX..SSSXEE...XXXSS...........---..XX.............XXXX........XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-...----...XXXXXXXXX-EE-...............................................................................
C7GK46_YEAS2/195-415                 .............................................................TIDIPEDRPELVNFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNE..RSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FTDAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQASQEPFYSFQIDTlPELDDSSIISTSISLSYD-...----...GDDNEKALTWEEL...............................................................................
E7Q927_YEASB/195-415                 .............................................................TIDIPEDRSELVNFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNE..RSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FTDAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEA.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQAAQEPFYSFQIDTlPELDDSSIISTSISLSYD-...----...GDDNEKALTWEEL...............................................................................
H2ARX1_KAZAF/267-523                 ............................................................f-IDIDPKNRRLFEYFSKIASEADLEKLLSN...............SQK...YEGLLQRFDNDETLLLS....................ELSHLSLN--NSDTSS----IK....HEEPTEmgIPFELKVYEKDLNVCFELSNGTDTYFSEN..LYLL..IHYISSEN.EI......WKTK.IDI-CHGIGPKSKRIFtKFksFFEKKGG.DFS.IEDFGF.........FEIKD..GADRLLFSTQGS..KLVPCN...NGTDL...........MFHlvAKynnlteinlrkleNFKS.........EETIKLKEAFTYDN.ENVESDDVISTTITNDVGF...ENND...SDNE---------feeydfl........................................................................
B5VRH1_YEAS6/163-412                 .............................................................CIILPEDKPELIKFFSKFETSVQLQEVYEG...............YKV...YEKLLQKFDGQKKRMESfln.............entpMSGAEAIKQINISEELKEKGER....LTTPND..PLLHVEVSNKDNSLHFILYNKTNIIIPGT..CTFE..FSSQISEV.FS......IK--.--MGPHEIGIKGQKEL.WFfpSLPTPLS.NYT.------.........MKVVN..QDGDTILVGKCA..DSNEIT...LKSPL...........---..--.............ASFStgsfqtgsfHTLQDPTNVFRADAlSSPDESSIMSTPFLGETDE...VYNS...GSTLSRPFTWEEI...............................................................................
H0H0S3_SACCK/80-324                  ............................................................y-VVLPEDKPELVEFFSHLKTSEQLQEIYNG...............YRV...YETLLQKFDGHKEKMHSflh.............egtsVPEGESMEQIALFEEPKEKNEA....LATPDD..RSLRVDVNHEDNSLHFILYNNADLIVPGN..CTFE..FSSSASKV.YS......IK--.--MGPHEIGPKGQKEL.WYfpSLSAPLV.DYT.------.........IKIIN..QNGDVIFIGKCT..ESNEVT...LKSAL...........---..--.............SSFStg.....sfNTLQDPNNVFRADAlSSFDESSVMSSPFSNEIDE...IYDS...GSTLNRPFTWEEI...............................................................................
G0W6A4_NAUDC/703-911                 .........................................................letd--------DETHDFISTLKTSEDLKKVVNG...............YPK...FKEWRYIGGKDESEIDEr..................fSSKDNMIAQVSINHELENIKKP....EEFLNS..TALEVTMERRYKDIKFTLTNRGKSDLPGN..SKFV..VQYSIEHHgVAh....vADVT.LDMGPHKLLIGSKKHL.LW..SPPCPIH.NGI.--VVDV.........VELST..-EDGFVFYSGKV..HDNNFE...LSTPA...........---..--.............----.........--------------.-------------------...----...-------------lsyehlevneqyynslekrkqvnl.......................................................
G0W3W6_NAUDC/275-439                 .............................................................TIKIPKSDGFLNEFYSKITTTEKLQDLAIG...............YNW...YKEWIQGCDNNEHLVSSai...............yqgK-------------------EY....MKGKMQ..CEVSIIVQRNETTWDVTLENISDDPLPKG..MKLV..--------.--......----.----------------.--..-------.---.------.........-----..------------..------...-----...........---..--.............----.........--------------.-------------------...----...-------------iesyespkqkrpvvvlstniggfppshadelelgptknlnedlrkylrsvikfvtnegevvystvfee...........
E7KI16_YEASA/195-415                 .............................................................TIDIPEDRPELVNFFTELKTVKQLEDVFQR...............YHD...YERLSQECDSKTE----....................---------IASDHSKKETKIE....VEPPNE..RSLQITMNQRDNSLYFQLFNNTNSVLAGN..CKLK..FTDAGDKP.TTq....iID--.--MGPHEIGIKEYKEY.RYfpYALDLEG.GST.------.........IEIEN..QYGEVIFLGKYG..SSPMIN...LRPPS...........---..RL.............SAES........lQASQEPFYSFQIDTlPELDDSSIISTSISLSYD-...----...GDDNEKALTWEEL...............................................................................
A0A024XW40_YEASX/163-412             .............................................................CIILPEDKPELIKFFSKFETSVQLQEVYEG...............YKV...YEKLLQKFDGQKKRMESfln.............entpMSGAEAIKQINISEELKEKGER....LTTPND..PLLHVEVSNKDNSLHFILYNKTNIIIPGN..CTFE..FSSQISEV.FS......IK--.--MGPHEIGIKGQKEL.WFfpSLPTPLS.NYT.------.........MKVVN..QDGDTILVGKCA..DSNEIT...LKSPL...........---..--.............ASFStgsfqtgsfHTLQDPTNVFRADAlSSPDESSIMSTPFLGETDE...VYNS...GSTLSRPFTWEEI...............................................................................
N1NZ43_YEASC/163-412                 .............................................................CIILPEDKPELIKFFSKFETSVQLQEVYEG...............YKV...YEKLLQKFGGQKKRMESfln.............entpMSGAEAIKQINISEELKEKGER....LTTPND..PLLHVEVSNEDNSLHFILYNKTNIIIPGN..CTFE..FSSQISEV.FS......IK--.--MGPHEIGIKGQKEL.WFfpSLPTPLS.NYT.------.........MKVVN..QDGETILVGKCA..DSNEIT...LKSPL...........---..--.............ASFStgsfqtgsfHTLQDPTNVFRADAlSSPDESSIMSTPFLGETDE...VYNS...GSTLSRPFTWEEI...............................................................................
#=GC SS_cons                         .............................................................XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...............XXX...XXXXXXXXXXXXX----....................---------XXXXXXXXXXXXX....XXXSSX..SXEEEEEEEETTEEEEEEEEXSSSXXXSS..XEEE..BXSSSSSX.BXX....XEE--.--XXSSXXXTTXEEEE.EESSXXXSXXT.TXX.------.........EEEEX..TTSSEEEEEXXX..SSSXEE...XXXSS...........---..XX.............XXXX........XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-...----...XXXXXXXXX-EE-...............................................................................
#=GC seq_cons                        .............................................................sI.lPED+sELlpFFoclcTspQLp-Vapt...............Y+s...YE+L.QchDuppc.................................Is.scphKEpp.c....lpsPs-...sLplphsp+DNSLaFpLaNpTspllsGN..CpLc..Fostsscs.so......Ic.....MGPHEIGIKt.KEh.paFP.h.s.hu.s.T................lcl.N..Q.G-sIalGKhu..sSs.ls...L+sP................................uu.S........hps.Q-Ph.sFphDsLsp.D-SSIhSTsho.phD...........uss.p+shTWEEl...............................................................................
//
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