GenomeNet

Database: Pfam
Entry: Activator-TraM
LinkDB: Activator-TraM
Original site: Activator-TraM 
#=GF ID   Activator-TraM
#=GF AC   PF11657.6
#=GF DE   Transcriptional activator TraM 
#=GF AU   Pollington J, Finn RD
#=GF SE   PRODOM
#=GF GA   22.70 22.70;
#=GF TC   23.00 22.80;
#=GF NC   22.40 22.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17475619
#=GF RT   Molecular basis of transcriptional antiactivation. TraM disrupts
#=GF RT   the TraR-DNA complex through stepwise interactions. 
#=GF RA   Qin Y, Su S, Farrand SK; 
#=GF RL   J Biol Chem. 2007;282:19979-19991.
#=GF RN   [2]
#=GF RM   15186414
#=GF RT   Quorum-sensing antiactivator TraM forms a dimer that dissociates
#=GF RT   to inhibit TraR. 
#=GF RA   Chen G, Malenkos JW, Cha MR, Fuqua C, Chen L; 
#=GF RL   Mol Microbiol. 2004;52:1641-1651.
#=GF DR   INTERPRO; IPR028140;
#=GF CC   TraM is required for quorum dependence. It binds to and
#=GF CC   in-activates TraR which controls the replication of the
#=GF CC   tumour-inducing virulence plasmid. TraM interacts in a two-step
#=GF CC   process with DNA-TraR to form a large, stable anti-activation
#=GF CC   complex [1,2].
#=GF SQ   16
#=GS L0H453_9GAMM/5-49       AC L0H453.1
#=GS E3HXT9_ACHXA/4-145      AC E3HXT9.1
#=GS C6BT68_DESAD/12-135     AC C6BT68.1
#=GS G9ELN8_9GAMM/2-143      AC G9ELN8.1
#=GS A0A0F7K566_9GAMM/4-141  AC A0A0F7K566.1
#=GS M1P2A7_BARAA/2-151      AC M1P2A7.1
#=GS G9EPF7_9GAMM/2-143      AC G9EPF7.1
#=GS A1WDS6_ACISJ/4-145      AC A1WDS6.1
#=GS E4PRS8_MARAH/2-144      AC E4PRS8.1
#=GS G4T4Q6_META2/3-144      AC G4T4Q6.1
#=GS A0A0M3B171_9RHIZ/2-144  AC A0A0M3B171.1
#=GS D3HLL5_LEGLN/2-143      AC D3HLL5.1
#=GS Q5NWI4_AROAE/2-143      AC Q5NWI4.1
#=GS C7RVV6_ACCPU/2-143      AC C7RVV6.1
#=GS E5YBS4_BILWA/1-143      AC E5YBS4.1
#=GS I1YLS3_METFJ/2-144      AC I1YLS3.1
L0H453_9GAMM/5-49                  .....d-DLIGDLIAEVARSHGVAISRDDPIVAVVLLNQIVL---------------------------------------------------------------..----.------.-----...----------------------------rryleetva.........................
E3HXT9_ACHXA/4-145                 ......DDKIEELIREIAVKHGIAVGRDDPILILQTINTRLMQDSQAAQQEILDRFKEELEAIAHRWGDDAKGKAERTLNAALAASKEAMAKGMQDGGKAAAEAV..RREL.EAAAAQ.LAAPI...REARRVSYMNIVAAGMAVFAAALALWAS..................................
C6BT68_DESAD/12-135                tiqsvr--------DLIAKEHNLLLDEDDPILVAVTINRAALDEYERLLQNHKQQLSKDMEEHVASFALEVRKSTNSLLSKAVKANIENCLSVINEHQ-------..----.------.-----...----------------------------gqmnnflgsvrglaifagvmfclsiavslsvivw
G9ELN8_9GAMM/2-143                 .....n-DKFDTVMQEIAVKHGVVLSKDDPILILQTMNDRLIEETQQAQAAMLAQFREEMESISSQWKDDAKEKAEKILNMALASSKEAMTHLLQEATNESVSVI..KKVI.SNSVAD.VHDMA...KQTKNYCLLVLFGSVLIVSCVYLALF--li................................
A0A0F7K566_9GAMM/4-141             ....dr----ERLIQEVAARWGLVISKDDPIIGAVALNDVVLDLHMGRLSSALEDQSTRLDSLNQQQINASKQIAKKIIGEALALATTEIRQQAKQTQQQTDQAV..GDQI.KALGAA.L----...----------------------------ddraalkrqlmwawstagflglllvvvllm....
M1P2A7_BARAA/2-151                 ...idf----DKIRKQVAIKHNVLLSEDDPILVIVTINEIILGHYFELISTQYDEAARVLTTSLQQQIELSKEIASKIITDSAEYVSDQMQQAINDAITPTLNEL..KEQV.NSVRAI.TNNAVinnQKAQKFVSTARLAAALSWAAAAITI---awglvilfv.........................
G9EPF7_9GAMM/2-143                 ......SDKFDAAIQEIAVRHGVVLNKDDPILILQTMNDRLIEESRQAQAAMLTEFREEMESISSQWRDDAKEKAEKIINAALAGSKEAMAKLLLESTNASVQSI..DRMI.SVSLAE.ARDLS...QQTKKFGWFMLVSSVVILAASSLFML--fl................................
A1WDS6_ACISJ/4-145                 ......DDKIEELIREIAVKHGIAVGRDDPILILQTINTRLMQDSQAAQQEILDRFKEELEAIAHRWGDDAKGKAERTLNAALTASKEAMAKGMQDGGKAAAEAV..RREL.EAAAVQ.FAAPV...REARRVAYMNIVAAGMAVFAAALALWAS..................................
E4PRS8_MARAH/2-144                 ......SDKIEETIKEIAAKHGIAVGRDDPILILQTINDRLMQESTAAQQANLDAFKSELEEIAHRWGDDAKNKAERTLNAALAASKEAMAATIKENAKATAAAA..RQQV.EEAIAQeLKPSI...REARRVSYMNLIAAGMAVFAAGLALWAS..................................
G4T4Q6_META2/3-144                 ......TDKIEETIKEIAVKHGIAVGRDDPILILQTINERLMQDSAAAQQEILDHFKEELEAIAHRWSDDAKNKAERTLNAALTASRETMTQTMQEGAKSAAELI..RREI.KAASAQ.FAAPI...HEAKRVALMNLVAAGMTIIAAGLVLWAA..................................
A0A0M3B171_9RHIZ/2-144             ......SDQIEELIREIAAKHGIAVGRDDPVLILHTINARLMADSAAKQEEILAAFKEELEGIAHRWGEDAKAKAERMLNAALAASKDAMAKVMKDSAAQAAEAI..RREI.DDGLGRqLAAKV...ADARRVAMMNMIAGGMVLFAAALVVWAS..................................
D3HLL5_LEGLN/2-143                 ......SEKLDKIIQDITVKHGVLLGKDDPILMLQTMNAQLIEENRKAQQDLLVQFREEMEGISSQWKDDAKEKAEKVLNAALASSKEAITKLLHEFTEESVQVM..KKLI.SDSLIE.AHSFA...QKTQKFSRFALVSSATLFAASCVVLLL-l.................................
Q5NWI4_AROAE/2-143                 ......SDKIESIIKEIAAKHGIAVGRDDPILVLQTINERLMQDSAVAQQETLDRFKEELESIAQRWGEDAKSKAERTLNAALTASKETMMKGMQEGTKAAAESA..RCEV.EAAVGR.LAGSV...RASQRIAIMNMIAGALAVFAAAMALLS-t.................................
C7RVV6_ACCPU/2-143                 ......ADPVEELIKEIAAKHGIAVSRDDPILILQTINTRLLQDSAKAQQVMLDQYKEELEALALRWGNDARDKAERILNASLTASKGAMVMVMQEGAREAAGVV..RGEV.DAALGR.VRGAM...RDARRVAALNVVASCITCLAAAVALWAA..................................
E5YBS4_BILWA/1-143                 .....m-DSLEEYIALIARENHVILDRKDSICILHTILAKFERDLLESQRKILDDFSGKIETLCLELDLAEKARSEKALSFAR-SSAEQLMKSIPTTMKATVEETsfKKLLaQTALAT.LKDQM...----------------------------svivhiprkvwiggsvlallnllslfl.......
I1YLS3_METFJ/2-144                 ......SDKIEETIKEIAAKHGIAVGRDDPILILQTINDRLMQESTAAQQANLDAFKSELEEIAHRWGDDAKNKAERTLNAALAASKEAMAATIKENAKATAAAA..RQQV.EEAIAQeLKPSI...REARRVSYMNLVAAGMVVFAAGLALWAS..................................
#=GC seq_cons                      ......sDplEclIcEIAsKHGlsluRDDPILILQTINsRLhp-ottAQpphL-pF+cELEuIuppWs-DAKpKAE+hLNAALsuSKEsMspshp-ssptsspsh..+cpl.psuhup.hts.h...ppsp+huhhshluushhhhAuulslh....................................
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