GenomeNet

Database: Pfam
Entry: Activator-TraM
LinkDB: Activator-TraM
Original site: Activator-TraM 
#=GF ID   Activator-TraM
#=GF AC   PF11657.7
#=GF DE   Transcriptional activator TraM 
#=GF AU   Pollington J, Finn RD
#=GF SE   PRODOM
#=GF GA   23.10 23.10;
#=GF TC   23.40 26.80;
#=GF NC   23.00 23.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17475619
#=GF RT   Molecular basis of transcriptional antiactivation. TraM disrupts
#=GF RT   the TraR-DNA complex through stepwise interactions. 
#=GF RA   Qin Y, Su S, Farrand SK; 
#=GF RL   J Biol Chem. 2007;282:19979-19991.
#=GF RN   [2]
#=GF RM   15186414
#=GF RT   Quorum-sensing antiactivator TraM forms a dimer that dissociates
#=GF RT   to inhibit TraR. 
#=GF RA   Chen G, Malenkos JW, Cha MR, Fuqua C, Chen L; 
#=GF RL   Mol Microbiol. 2004;52:1641-1651.
#=GF DR   INTERPRO; IPR028140;
#=GF CC   TraM is required for quorum dependence. It binds to and
#=GF CC   in-activates TraR which controls the replication of the
#=GF CC   tumour-inducing virulence plasmid. TraM interacts in a two-step
#=GF CC   process with DNA-TraR to form a large, stable anti-activation
#=GF CC   complex [1,2].
#=GF SQ   42
#=GS A0A139SPK0_9GAMM/2-66   AC A0A139SPK0.1
#=GS A0A0W0YZ92_LEGSP/2-143  AC A0A0W0YZ92.1
#=GS G9ELN8_9GAMM/2-143      AC G9ELN8.1
#=GS S3XB09_9PROT/2-88       AC S3XB09.1
#=GS A0A0W0V9R6_9GAMM/2-140  AC A0A0W0V9R6.1
#=GS A0A0W0U8M5_9GAMM/2-144  AC A0A0W0U8M5.1
#=GS G9EPF7_9GAMM/2-143      AC G9EPF7.1
#=GS E4PRS8_MARAH/2-144      AC E4PRS8.1
#=GS F9ZDB7_9PROT/3-141      AC F9ZDB7.1
#=GS U1ZVN3_9PSED/4-145      AC U1ZVN3.1
#=GS N1MKF4_9SPHN/4-142      AC N1MKF4.1
#=GS C6BT68_DESAD/11-112     AC C6BT68.1
#=GS A0A0W0YKE1_9GAMM/2-143  AC A0A0W0YKE1.1
#=GS T0GPP6_9SPHN/4-142      AC T0GPP6.1
#=GS C7RVV6_ACCPU/2-143      AC C7RVV6.1
#=GS A0A0A2STU4_9GAMM/2-145  AC A0A0A2STU4.1
#=GS W7X2I1_9BURK/1-143      AC W7X2I1.1
#=GS A0A139SPZ3_9GAMM/2-75   AC A0A139SPZ3.1
#=GS F0TD83_9PROT/6-147      AC F0TD83.1
#=GS E5YBS4_BILWA/1-143      AC E5YBS4.1
#=GS A0A0W0U6Q7_9GAMM/2-144  AC A0A0W0U6Q7.1
#=GS F0TD36_9PROT/6-147      AC F0TD36.1
#=GS A0A0W0Z6M1_LEGSP/2-142  AC A0A0W0Z6M1.1
#=GS L0WCD8_9GAMM/2-144      AC L0WCD8.1
#=GS A0A0W0VRK1_9GAMM/2-143  AC A0A0W0VRK1.1
#=GS F9ZH58_9PROT/1-129      AC F9ZH58.1
#=GS A0A0F7K566_9GAMM/4-141  AC A0A0F7K566.1
#=GS Q0ACZ2_NITEC/2-145      AC Q0ACZ2.1
#=GS A0A0W0V378_9GAMM/2-143  AC A0A0W0V378.1
#=GS V5BZK5_9GAMM/27-179     AC V5BZK5.1
#=GS A1WDS6_ACISJ/4-145      AC A1WDS6.1
#=GS G4T4Q6_META2/3-144      AC G4T4Q6.1
#=GS A0A0W1A2Y9_9GAMM/2-143  AC A0A0W1A2Y9.1
#=GS D3HLL5_LEGLN/2-143      AC D3HLL5.1
#=GS A0A0M3B171_9RHIZ/2-144  AC A0A0M3B171.1
#=GS Q5NWI4_AROAE/2-143      AC Q5NWI4.1
#=GS A0A0W1AGC8_9GAMM/2-143  AC A0A0W1AGC8.1
#=GS A0A011P4Z2_9PROT/1-59   AC A0A011P4Z2.1
#=GS A0A139SVT0_9GAMM/3-147  AC A0A139SVT0.1
#=GS A0A0W0WNE2_9GAMM/2-143  AC A0A0W0WNE2.1
#=GS A0A0X8JRB5_9DELT/1-141  AC A0A0X8JRB5.1
#=GS I1YLS3_METFJ/2-144      AC I1YLS3.1
A0A139SPK0_9GAMM/2-66              ..ald---LEAVAAEIGKRHGIKITKDDPIMILVTVIALLEQEMFQQKQKLMTDVVSEVEAFMTRN---------------------------....---------.....--..---.----..-....--.---------------------.------------negs...........................
A0A0W0YZ92_LEGSP/2-143             .....TDKMNEAIKDIAFRHGVVLGKDDPVLILQTMNEKLLAENRKEQEAMLAQFKEEMENISSQWKDDAKDKAERVLNAALASSKETMDKIL....RQATHESAL.....VM..QKM.ISDS..L....KE.ARVLNQQTQKTSQFKLLSSAV.LLTVSCTFI---lff............................
G9ELN8_9GAMM/2-143                 ....n-DKFDTVMQEIAVKHGVVLSKDDPILILQTMNDRLIEETQQAQAAMLAQFREEMESISSQWKDDAKEKAEKILNMALASSKEAMTHLL....QEATNESVS.....VI..KKV.ISNS..V....AD.VHDMAKQTKNYCLLVLFGSVL.IVSCVYLALF--li.............................
S3XB09_9PROT/2-88                  ..dkk-----AIINEIAQKHNIILDENDPILAVVSANETIFNEFEKRLENMLIKQKMDLESYKNNIIQEFKNQ--------------------....---------.....--..---.----..-....--.---------------------.------------dkiifdilehtaklqnsqiki..........
A0A0W0V9R6_9GAMM/2-140             .....SEKINEAIQDIAGKHGVVLGRDDPVLILQTMNDRLLEENRKAQQEMLTQFKEEMESISSQWKVDAKDKAEKVLNAALASSKEAMNKML....GEATNESVL.....IM..RNL.ISDA..L....ME.ARDLTHQTRTRNQLALLSLFA.MLTVTC------lfm............................
A0A0W0U8M5_9GAMM/2-144             .....TDQFDAVIRDIAIKHGVVLSKDDPILILQTMNDRLIEETRQAQAAMLAQFREEMESISSQWKVDAKEKAEKVLNAALASSKEAMNKML....REATNEFVH.....VI..KNV.ISDS..L....TE.AKNLTQQTSKANRFTLLTSVS.MVAISCAFM---lyll...........................
G9EPF7_9GAMM/2-143                 .....SDKFDAAIQEIAVRHGVVLNKDDPILILQTMNDRLIEESRQAQAAMLTEFREEMESISSQWRDDAKEKAEKIINAALAGSKEAMAKLL....LESTNASVQ.....SI..DRM.ISVS..L....AE.ARDLSQQTKKFGWFMLVSSVV.ILAASSLFML--fl.............................
E4PRS8_MARAH/2-144                 .....SDKIEETIKEIAAKHGIAVGRDDPILILQTINDRLMQESTAAQQANLDAFKSELEEIAHRWGDDAKNKAERTLNAALAASKEAMAATI....KENAKATAA.....AA..RQQ.VEEA..I....AQeLKPSIREARRVSYMNLIAAGM.AVFAAGLALWA-s..............................
F9ZDB7_9PROT/3-141                 ....n-NKLDALIERIASEHGIVLSQDDPVLMMHTLNEVLLEQNKEAHAELLSNYQAILEENFNRWCEYSTKKSNAIISASMSNAQLT----R....DQFLESCIQ.....LI..DEK.IKSR..E....GQeIYELTRISRQAAIINLLASTL.ILVSVAIIFF--il.............................
U1ZVN3_9PSED/4-145                 ....d-DKIEELIREIAAKHGIAVGRDDPILILQTINMKLMQDSASAQQEILDAFKSELESIAHRWGDDAKGKAERTLNAALAASKDAMTRGM....QEGAKAAAE.....AV..RRE.VEAV..T....AQ.LVAPIREARRVAMMNMVAAGM.AVVAAGLALWA-s..............................
N1MKF4_9SPHN/4-142                 ....h-EKIAALIAEISRQHGVTLSADDPLMILQTINAMLLGESADAQEEQLKAFKSELEDMSNRWSIAITDKAESVLNAALDASEAAMNERM....G----AAAK.....AI..IKE.VGEH..I....GTgLQKPLNDGRAVANRNLLASGL.TLIAALVVLAA-a..............................
C6BT68_DESAD/11-112                ltiqs------VRDLIAKEHNLLLDEDDPILVAVTINRAALDEYERLLQNHKQQLSKDMEEHVASFALEVRKSTNSLLSKAVKANIENCLSVI....NEHQ-----.....--..---.----..-....--.---------------------.------------gqmnnflgsvr....................
A0A0W0YKE1_9GAMM/2-143             .....SDKINETIKDIAVKHGVVLGKDDPVLIFQTMNERLLEENRKVQQDMLAFFKGEMEAISSQWKNDAQEKAEKVLNVALASSKEAMARLL....QESTRESVQ.....SM..KKM.ISDS..L....IE.AHIMAQQTQKFSRFALLSSVA.LFATSCMLIL--lf.............................
T0GPP6_9SPHN/4-142                 ...ha--KIRALIAEIAATHGVALSPDDPLLILQTINTMLLAESADAQQAQLEAFKSELEEMSNRWAVAINDKAESILNAALVAAEAAMKQRM....ADGAKTLVA.....EV..AAE.VSKG..L....GK.---PLEDGVRIANRNLIASCL.TIGAAIIALLA-v..............................
C7RVV6_ACCPU/2-143                 .....ADPVEELIKEIAAKHGIAVSRDDPILILQTINTRLLQDSAKAQQVMLDQYKEELEALALRWGNDARDKAERILNASLTASKGAMVMVM....QEGAREAAG.....VV..RGE.VDAA..L....GR.VRGAMRDARRVAALNVVASCI.TCLAAAVALWAA...............................
A0A0A2STU4_9GAMM/2-145             .....SEKINEAIQDIAGKHGVVLGRDDPVLIFQTMNDRLLEENRKAQQEMLTQFKEEMESISSQWKVDAKDKAEKVLNAALASSKEAMNKIL....REATNEFVQ.....VM..KNV.VSDS..L....TE.AKDLTQQTRKANRFTLLTLVT.MLTVSCAF----mlflli.........................
W7X2I1_9BURK/1-143                 ....m-DKIEDTIREIAAKHGIAVGRDDPILILHTINDRLMRESSEAQKEILDRFKEELESVAQRWEIDAKKMAERTLNAALTASKDAMSQAM....QDGASASVQ.....TV..RKE.LAAA..T....EQ.VKNSMASAKRMVLVTLAASSFlAVFSIGLV----altv...........................
A0A139SPZ3_9GAMM/2-75              ...lg---------------------------------------------------------------EAKNQAQAIINKTLIESKKD----L....QEAITQTVQ.....TR..TAN.IK--..-....AQ.LEPSIERARQAAYISLMAGCV.AVLASGIAFWAA...............................
F0TD83_9PROT/6-147                 ....l-DHFSKIIERVAAKHGIALTDDDPILMIHTLNEILLEENNKAHQVLLNNFRSTLEENISQWSQATESKANNLLQASSRNINLLTEQII....NACFESIGQ.....KI..ESS.FNEK..I....EE.VSTLARSTWQAAIINLLATGL.FFLAVLVMVL--vf.............................
E5YBS4_BILWA/1-143                 ....m-DSLEEYIALIARENHVILDRKDSICILHTILAKFERDLLESQRKILDDFSGKIETLCLELDLAEKARSEKALSFAR-SSAEQLMKSI....PTTMKATVE.....ETsfKKLlAQTA..L....AT.LKDQM----------------.------------svivhiprkvwiggsvlallnllslfl....
A0A0W0U6Q7_9GAMM/2-144             .....TDKLQEITQEIAKRHGVLVGRDDPILMLHTMNDMLMQENLAAQRNVLADFRTMIEEGIHRLEDGSSKKSEQILNVAILASKTLLQNAM....QDGAESAMS.....FI..NQE.IDKK..S....KA.HLFALKKACTVAWVNLSVSGV.VLIGTCILA---llhs...........................
F0TD36_9PROT/6-147                 ..lnh---FSKIIERVAAKHGIALSDDDPILMIHTLNEILLEENSKAHQVLLNNFRSTLEENISQWSQATENKANSLLQASSRNTNLLTEQII....NSCFESIDQ.....KI..ESG.FNEK..I....KE.IATIVRNTRQAAIINLLATGL.FFLTVLVMV---lvf............................
A0A0W0Z6M1_LEGSP/2-142             .....SDKLNEVIQDIAIKHGVVLAKNDPVLILQTMNDRLLEENRKAQEELLVKFREEMEGISSQWKDDAKEKAENVINATLAASKEVMAKLL....RESTSESVQ.....AM..KKI.VSDS..L....IE.AKDLTERTWRYCWIAF-GSMI.TLLGCC------ffilif.........................
L0WCD8_9GAMM/2-144                 .....SDKIEETIKEIAAKHGIAVGRDDPILILQTINDRLMQESTAAQQANLDAFKSELEEIAHRWGDDAKNKAERTLNAALTASKEAMAATI....KENAKATAA.....AA..RQQ.VEEA..I....AQeLKPSIREARRVSYMNLVAAGM.VVFAAGLALWA-s..............................
A0A0W0VRK1_9GAMM/2-143             .....SEKLDKIVQDITVKHGVLLGKDDPILMLQTMNEQLIEENRKAQQDLLVKFREEMEGISSQWKDDAKEKAEKVLNAALASSKEAITRLL....HESTKESVQ.....AM..QKL.LSDS..L....IE.ARSLTRKTQKFSQFALVSSAT.LFAVSFTILL--lf.............................
F9ZH58_9PROT/1-129                 ....m-----------APEHGIVLSQDDPVLMMHTLNEVLLEQNEKAHAELLSNYQAILEENFNRWCEYSTKKSNAIISASMSNAQLTRDQFM....----ESCIQ.....LI..DER.IKSG..V....DQeTYDLARVSRQAAIINLMASTL.FLVSVVIIF---lil............................
A0A0F7K566_9GAMM/4-141             ...dr----ERLIQEVAARWGLVISKDDPIIGAVALNDVVLDLHMGRLSSALEDQSTRLDSLNQQQINASKQIAKKIIGEALALATTEIRQQA....KQTQQQTDQ.....AV..GDQ.IKAL..G....AA.---------------------.------------lddraalkrqlmwawstagflglllvvvllm
Q0ACZ2_NITEC/2-145                 ...id---FEEIRKQIAIKHNVLLDKDDPILVTITINEIVLSRYLDLVTERYSDASRDLTIALLHQQEESKRIAEKIITEASDYVSNQVRQSV....EESILEASK.....NL..KQQsLGNN..I....AS.SNYYAQKAEKKATLATIMAVV.STVVAVVALV--vval...........................
A0A0W0V378_9GAMM/2-143             .....SDKMNETIQDIAVKHGVVLGKDDPILILQTMNDRLLEENRKALQDMLAQFKEEMENISSQWKDDAKEKAEKVLSAALVSSKEAMTRLL....HETTNESVH.....VI..KKL.ISDS..L....VE.SRELSRTIRKFNQFTLLTSAA.IFCLM-------pvfywfl........................
V5BZK5_9GAMM/27-179                ....d-DGMEAIIRAVAVKHGIALGNNDPILVLQTINGLLLDEFARKQEVLIHEFHVNLEAAADLWSKNMESKASEILGNMENSHRHLINELIeqqiENLAREIADksgdiTM..EQQ.LRASkhL....RS.LNSQLKTMRSMLYVNFAASIM.ALVSAIVMLWL-s..............................
A1WDS6_ACISJ/4-145                 ....d-DKIEELIREIAVKHGIAVGRDDPILILQTINTRLMQDSQAAQQEILDRFKEELEAIAHRWGDDAKGKAERTLNAALTASKEAMAKGM....QDGGKAAAE.....AV..RRE.LEAA..A....VQ.FAAPVREARRVAYMNIVAAGM.AVFAAALALWA-s..............................
G4T4Q6_META2/3-144                 .....TDKIEETIKEIAVKHGIAVGRDDPILILQTINERLMQDSAAAQQEILDHFKEELEAIAHRWSDDAKNKAERTLNAALTASRETMTQTM....QEGAKSAAE.....LI..RRE.IKAA..S....AQ.FAAPIHEAKRVALMNLVAAGM.TIIAAGLVLWAA...............................
A0A0W1A2Y9_9GAMM/2-143             .....SDTINEAIKTIAVKHGVVLGKDDPILILQTMNEKLLEENRKAQQVMLTQFKEEMENISSQWKVDAKEKAEKLLNAALASSKEAMNKLL....RDATNEFVH.....AM..KNV.ISDS..L....AK.AKDLTQQTSKASRFTWLTSVT.IFAVSCTFM---lfi............................
D3HLL5_LEGLN/2-143                 .....SEKLDKIIQDITVKHGVLLGKDDPILMLQTMNAQLIEENRKAQQDLLVQFREEMEGISSQWKDDAKEKAEKVLNAALASSKEAITKLL....HEFTEESVQ.....VM..KKL.ISDS..L....IE.AHSFAQKTQKFSRFALVSSAT.LFAASCVVLLL-l..............................
A0A0M3B171_9RHIZ/2-144             .....SDQIEELIREIAAKHGIAVGRDDPVLILHTINARLMADSAAKQEEILAAFKEELEGIAHRWGEDAKAKAERMLNAALAASKDAMAKVM....KDSAAQAAE.....AI..RRE.IDDG..L....GRqLAAKVADARRVAMMNMIAGGM.VLFAAALVVWA-s..............................
Q5NWI4_AROAE/2-143                 .....SDKIESIIKEIAAKHGIAVGRDDPILVLQTINERLMQDSAVAQQETLDRFKEELESIAQRWGEDAKSKAERTLNAALTASKETMMKGM....QEGTKAAAE.....SA..RCE.VEAA..V....GR.LAGSVRASQRIAIMNMIAGAL.AVFAAAMALLS-t..............................
A0A0W1AGC8_9GAMM/2-143             .....SEKLDKIIQDISIKHGVLLGKDDPILMLQTMNAQLIEEHRKAQQDLLVQFREEMEGISSQWKDDAKEKAEKVLNAALASSKEAITRLL....NESTKESVQ.....AM..QKL.ILNS..L....TE.AHSLTRKTQKFSQFVLVLSAT.LFVASCMIFL--lf.............................
A0A011P4Z2_9PROT/1-59              .....-----------------------------------------------------------------------------------MGKVM....QEGAKEAAA.....KV..RGE.VDAA..L....GR.VTGAMGDARRVATLNVVASCV.ACLAAAVALWAT...............................
A0A139SVT0_9GAMM/3-147             ...id---LDALAAEIGRRHGLKLDKDDPIMIVVTAVAMLEQEMFRHKQKLMAEVVSEVEAFMTRNNEYISTIVNQMLGEAKNQAQAIINKTL....IESKKDLQE.....AI..TQT.VQTR..TanirAQ.LEPSIERARQAAYMSLMAGGV.AVLAAMIVLWA-s..............................
A0A0W0WNE2_9GAMM/2-143             ....t-NEFDKTIQEIAIKHGVVLSKDDPILILHTMNENLLAETRQAQALMLTQFREEMEKISSQWKDDAKEKAEKILNVALTGSKEAMARLL....QESTSESVQ.....AM..KKV.ILAA..L....TE.TRDLTLQTRKFSRFTLLLSTA.MLIASGLFML--pf.............................
A0A0X8JRB5_9DELT/1-141             ....m-EPVESYISAVAMKDGNIVKKGDPILCLHTILEKFEEDFLRSQQNLLAAFQVALETEYAKWNAESTARAERVLSSSLAAAKKDADTVF....RAAADEELA.....LL..GAA.LNEK..L....EE.VKGYQISAKRIAVLSFICALL.FLL---------svvgmflk.......................
I1YLS3_METFJ/2-144                 .....SDKIEETIKEIAAKHGIAVGRDDPILILQTINDRLMQESTAAQQANLDAFKSELEEIAHRWGDDAKNKAERTLNAALAASKEAMAATI....KENAKATAA.....AA..RQQ.VEEA..I....AQeLKPSIREARRVSYMNLVAAGM.VVFAAGLALWA-s..............................
#=GC seq_cons                      ......-plcchIp-IAsKHGlsLu+DDPILlLpThN-pLhpEstpAQpphLspF+pEhEsluspWpp-uKpKAE+lLNAALsuSKcshsphh....p-usppssp.....sh..cp..lpsu..l....sp.hps.hppsp+huhhsLluush.hlhsushhh..................................
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