GenomeNet

Database: Pfam
Entry: Activator-TraM
LinkDB: Activator-TraM
Original site: Activator-TraM 
#=GF ID   Activator-TraM
#=GF AC   PF11657.5
#=GF DE   Transcriptional activator TraM 
#=GF AU   Pollington J, Finn RD
#=GF SE   PRODOM
#=GF GA   22.70 22.70;
#=GF TC   23.00 22.80;
#=GF NC   20.80 22.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17475619
#=GF RT   Molecular basis of transcriptional antiactivation. TraM disrupts
#=GF RT   the TraR-DNA complex through stepwise interactions. 
#=GF RA   Qin Y, Su S, Farrand SK; 
#=GF RL   J Biol Chem. 2007;282:19979-19991.
#=GF RN   [2]
#=GF RM   15186414
#=GF RT   Quorum-sensing antiactivator TraM forms a dimer that dissociates
#=GF RT   to inhibit TraR. 
#=GF RA   Chen G, Malenkos JW, Cha MR, Fuqua C, Chen L; 
#=GF RL   Mol Microbiol. 2004;52:1641-1651.
#=GF DR   INTERPRO; IPR028140;
#=GF CC   TraM is required for quorum dependence. It binds to and
#=GF CC   in-activates TraR which controls the replication of the
#=GF CC   tumour-inducing virulence plasmid. TraM interacts in a two-step
#=GF CC   process with DNA-TraR to form a large, stable anti-activation
#=GF CC   complex [1,2].
#=GF SQ   10
#=GS L0H453_9GAMM/5-49    AC L0H453.1
#=GS D3HLL5_LEGLN/2-143   AC D3HLL5.1
#=GS E3HXT9_ACHXA/4-145   AC E3HXT9.1
#=GS Q5NWI4_AROAE/2-143   AC Q5NWI4.1
#=GS C6BT68_DESAD/12-135  AC C6BT68.1
#=GS C7RVV6_ACCPU/2-143   AC C7RVV6.1
#=GS M1P2A7_BARAA/2-151   AC M1P2A7.1
#=GS A1WDS6_ACISJ/4-145   AC A1WDS6.1
#=GS I1YLS3_METFJ/2-144   AC I1YLS3.1
#=GS G4T4Q6_META2/3-144   AC G4T4Q6.1
L0H453_9GAMM/5-49               .....d-DLIGDLIAEVARSHGVAISRDDPIVAVVLLNQIVL-------------------------------------------------------------------------.-----...----------------------------rryleetva.........................
D3HLL5_LEGLN/2-143              ......SEKLDKIIQDITVKHGVLLGKDDPILMLQTMNAQLIEENRKAQQDLLVQFREEMEGISSQWKDDAKEKAEKVLNAALASSKEAITKLLHEFTEESVQVMKKLISDSLIE.AHSFA...QKTQKFSRFALVSSATLFAASCVVLLL-l.................................
E3HXT9_ACHXA/4-145              ......DDKIEELIREIAVKHGIAVGRDDPILILQTINTRLMQDSQAAQQEILDRFKEELEAIAHRWGDDAKGKAERTLNAALAASKEAMAKGMQDGGKAAAEAVRRELEAAAAQ.LAAPI...REARRVSYMNIVAAGMAVFAAALALWAS..................................
Q5NWI4_AROAE/2-143              ......SDKIESIIKEIAAKHGIAVGRDDPILVLQTINERLMQDSAVAQQETLDRFKEELESIAQRWGEDAKSKAERTLNAALTASKETMMKGMQEGTKAAAESARCEVEAAVGR.LAGSV...RASQRIAIMNMIAGALAVFAAAMALLS-t.................................
C6BT68_DESAD/12-135             tiqsvr--------DLIAKEHNLLLDEDDPILVAVTINRAALDEYERLLQNHKQQLSKDMEEHVASFALEVRKSTNSLLSKAVKANIENCLSVINEHQ-----------------.-----...----------------------------gqmnnflgsvrglaifagvmfclsiavslsvivw
C7RVV6_ACCPU/2-143              ......ADPVEELIKEIAAKHGIAVSRDDPILILQTINTRLLQDSAKAQQVMLDQYKEELEALALRWGNDARDKAERILNASLTASKGAMVMVMQEGAREAAGVVRGEVDAALGR.VRGAM...RDARRVAALNVVASCITCLAAAVALWAA..................................
M1P2A7_BARAA/2-151              ...idf----DKIRKQVAIKHNVLLSEDDPILVIVTINEIILGHYFELISTQYDEAARVLTTSLQQQIELSKEIASKIITDSAEYVSDQMQQAINDAITPTLNELKEQVNSVRAI.TNNAVinnQKAQKFVSTARLAAALSWAAAAITI---awglvilfv.........................
A1WDS6_ACISJ/4-145              ......DDKIEELIREIAVKHGIAVGRDDPILILQTINTRLMQDSQAAQQEILDRFKEELEAIAHRWGDDAKGKAERTLNAALTASKEAMAKGMQDGGKAAAEAVRRELEAAAVQ.FAAPV...REARRVAYMNIVAAGMAVFAAALALWAS..................................
I1YLS3_METFJ/2-144              ......SDKIEETIKEIAAKHGIAVGRDDPILILQTINDRLMQESTAAQQANLDAFKSELEEIAHRWGDDAKNKAERTLNAALAASKEAMAATIKENAKATAAAARQQVEEAIAQeLKPSI...REARRVSYMNLVAAGMVVFAAGLALWAS..................................
G4T4Q6_META2/3-144              ......TDKIEETIKEIAVKHGIAVGRDDPILILQTINERLMQDSAAAQQEILDHFKEELEAIAHRWSDDAKNKAERTLNAALTASRETMTQTMQEGAKSAAELIRREIKAASAQ.FAAPI...HEAKRVALMNLVAAGMTIIAAGLVLWAA..................................
#=GC seq_cons                   ......sDKIE-lI+EIAsKHGIAVGRDDPILlLQTINpRLhQ-SttAQQphLDpFKEELEuIApRWu-DAKsKAERsLNAALsASKEsMspshpEus+suApshRpplcuAhup.htusl...+cApRluhhNlVAuuhshhAAulsLhu...................................
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