GenomeNet

Database: Pfam
Entry: Activator_LAG-3
LinkDB: Activator_LAG-3
Original site: Activator_LAG-3 
#=GF ID   Activator_LAG-3
#=GF AC   PF11498.3
#=GF DE   Transcriptional activator LAG-3
#=GF AU   Pollington J
#=GF SE   pdb_2fo1
#=GF GA   23.30 23.30;
#=GF TC   23.70 24.90;
#=GF NC   22.50 23.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Transcriptional_activator_LAG-3
#=GF RN   [1]
#=GF RM   10830967
#=GF RT   LAG-3 is a putative transcriptional activator in the C. elegans
#=GF RT   Notch pathway. 
#=GF RA   Petcherski AG, Kimble J; 
#=GF RL   Nature. 2000;405:364-368.
#=GF DR   INTERPRO; IPR021587;
#=GF CC   The C.elegans Notch pathway, involved in the control of growth,
#=GF CC   differentiation and patterning in animal development, relies on
#=GF CC   either of the receptors GLP-1 or LIN-12 [1]. Both these
#=GF CC   receptors promote signalling by the recruitment of LAG-3 to
#=GF CC   target promoters, where it then acts as a transcriptional
#=GF CC   activator. LAG-3 works as a ternary complex together with the
#=GF CC   DNA binding protein, LAG-1 [1].
#=GF SQ   17
#=GS E3LT94_CAERE/1-429    AC E3LT94.1
#=GS D3B9N7_POLPA/497-706  AC D3B9N7.1
#=GS G0NJW7_CAEBE/246-507  AC G0NJW7.1
#=GS G0NK02_CAEBE/1-265    AC G0NK02.1
#=GS G0PAI3_CAEBE/257-396  AC G0PAI3.1
#=GS A8X9K8_CAEBR/1-408    AC A8X9K8.1
#=GS LAG3_CAEEL/23-490     AC Q09260.2
#=GS LAG3_CAEEL/23-490     DR PDB; 2FO1 D; 52-114;
#=GS E9GBC6_DAPPU/110-221  AC E9GBC6.1
#=GS H2WH88_CAEJA/1-436    AC H2WH88.1
#=GS G0PAI3_CAEBE/1-267    AC G0PAI3.1
#=GS C1C552_DROME/236-381  AC C1C552.1
#=GS G0PAI6_CAEBE/1-253    AC G0PAI6.1
#=GS G0N5R2_CAEBE/1-470    AC G0N5R2.1
#=GS G0NJW7_CAEBE/501-627  AC G0NJW7.1
#=GS Q9VLX5_DROME/230-375  AC Q9VLX5.4
#=GS G0PAI6_CAEBE/245-386  AC G0PAI6.1
#=GS G0NK02_CAEBE/253-380  AC G0NK02.1
E3LT94_CAERE/1-429               ................................................................................................................................................MKPSTSKtssLSHSPPPEEPTVPYVNDNLPNPENEPCVSDISLFELGEERHRQKSKQAAEKYGRIIPALVADQRAVTGHLFHRYTEDEERKRLEQQKNKEAMSASAA--PTSRNG--HIgENRKRRND-AVAQPT-EEDWRRVqQ.QQHWMAQSQMPN.GFHLQQQ.....QFLHQQ-..----Q......QQQQQYL---.---.-..---------A...HQSVPTP-ASMHQPSPVEMQNVG----------------DRLSAVDENILNVPDGKWFDELAEIVAENYNADTVLGPDTYDTFLNELESTEPIAETSKSPMEKIIDRIPSAATV--Q...N.P.QQLAQQQQQ..hQNKMRLLQQQQQeqqqqlqqqEMQRLEQQR.QQQQQQQQIlQQ.QHQQ.RQQQQMLL----QQQQMQQHNQMN-GAQF-AQA.-QQAAYMQ..Q..M..QRM...HHIRYQQQQHQQQQL--HQLPQPHQNAAMGYGIPNGYP.QQMHMHhAPPYA-HHMPQHTPFANIN...................................
D3B9N7_POLPA/497-706             ptttttiatptsspiatttaaatsspiakttsspiatttttttaatpittattspspiakttsspiatatessnankaaqvlnqtketspiltptspiittplssyhadnnssttfasapapastnininassenvkttiaiss-------...-------------------------------------------------------------------------------------------------------------.-----------------------.-.------------.-------.....-------..-----......----------.---.-..----------...---------------------------------------------------------------------------------------------------------------------...-.-.-----SAQA...TVP---------.........--TSINQQV.AQQQQQQQQ.QQ.QQQQ.QQQQQQQQQQQQQQQQQQQQQQQ----------.--------..-..-..---...--------------------------------------.------.-------------------qtkttlssrrntkr.....................
G0NJW7_CAEBE/246-507             ................................................................................................................................................MKPLTSK...VSVAPISEEPLTKYVNYNLPNPDDEPYVSDMHNYQAGEELHCQQSQLAKERYTIALPEMIDANRGVFAELFTRFTEDDKRKKAEMQKNKEAMAASAP-PLFRHSG----.DSRKRRNDVMV--ESAEEEWKRQpH.QQQWMVQSQMQQyPHHVQQQ.....QYMQMQ-..---MA......AQQQQHQGIQ.MHHnN..QMPSTTTADS...ARSVHTP-ASIYQQSPMEGRNGNRMAPSGSGMNTDSPTSGSDQQTDENTLAFPEGDWFEKLKVTVAEPDDVN---------------------------------------------...-.-.---------...------------.........---------.---------.--.----.---------------------------------.--------..-..-..---...--------------------------------------.------.-------------------vaqq...............................
G0NK02_CAEBE/1-265               ................................................................................................................................................MKPSTSK...VSVAPIPEKPLTKYVNYNLPNPDDEPYVSDMRNYQAGEELHREQSQLAKEKYTIALPEMINANRGVSAELFTRFTEDEKRKKAEMQKNKDAMAASAA-PLSRHSG----.DSRKRRND--VMAQSAEEEWKRQpH.QQQWLAQSQMQQyPHHVQQH.....YYMQMQ-..MAAQQ......QQHHGIQ-M-.HHN.N..QMPSTSTADS...ARSVHTP-ALIHQQSPIEGRNGNKMAPSRSGMNTSSPTTDLDQQTDENTLAVPEEDWFENLAVTPAD--------------------------------------------------...-.-.---------...------------.........---------.---------.--.----.---------------------------------.--------..-..-..---...--------------------------------------.------.-------------------gmingvaqqlpp.......................
G0PAI3_CAEBE/257-396             ...................................................................................................................................tpangivngvaqq-------...-------------------------------------------------------------------------------------------------------------.-----------------------.-.------------.-------.....-------..-----......----------.---.-..----------...---------------------------------------------------------------------------------------------------------------IPSPIQrlpT.P.QP-QQHDQQ...QQKMRMLQQQEM.........--QRMEHQR.HQQLLQAQL.AQ.--QR.HQQQQMILQQQ-------PQHQMNGGFQL--HA.QQQAAYMQ..-..A..QRM...HQMRMQQHQQQQQLHRHQQQQHHHQNGGMGYDMPNGYP.H-----.-------------------k..................................
A8X9K8_CAEBR/1-408               ................................................................................................................................................MKPSTSKagsSAQSPPPEEPNSAYVNNELPDPDDEPLVSEMTVYNKGQEEARLRSQEAYEKFQKTRQESISSQRAVTAQLYHRFTEDEERKRMEHQKNKEAMNASVA--SASRNG--HI.DNRKRRND--VGSLSAEEEWRRAqQ.QQHWMGQAAPMHpSYQMQQQ.....YH-QQQ-..---VA......AQHHQFM---.---.-..---------A...PHSVPTP-GSIHRPSPSGMQSVC------------------LPTSDENSLDVPNGEWFDKLAVMVAEKYDATTILGPDTYDVYLNELDAMEPVGETVKTPSEAG-----QSASQP-M...N.P.QQ-QQMAQQ...QNKMRMLQQQEM.........----MEQQR.QQQMMHQHQ.QQ.----.HRQQQMLL-QQQQMHQLQQQNQMN-GGQF-TQA.QQHAVYLQ..R..M..QHMrlqQQQQQQQQQAQHHQQA-QQHQQPHQNGVMGYSVPNGY-.AHPNGY.AP-YG-HHMPHHTPFANIN...................................
LAG3_CAEEL/23-490                ................................................................................................................................................MKPSTSK...TTHSPPPEEPTAPFVNDNLPNPEDEPTIGDLNAFHSGEELHRQRSELARANYEKARPEMIANQRAVTAHLFNRYTEDEERKRVEQQKNKEAMNASTSAPTSSRNGGQSV.ENRKRRNDVVVAPPTSEEEWKRA.Q.QQHWMGQQQPQM.QFQMQQQ.....YHSQQQQ..YIMMQ......QQHHHMTGMQ.QIH.H..QMPSTSSADS...IRSVPTPASSMHQPSPAEMRNGCGMSRNATMDMTCSPMSGGQPIVDENNLAVPEGEWFDKLALAVAEQYNVDTILGPDTYDTFLAELDFSSSESPTKQSPMEMNGDRMPSTAPPPAQ...N.P.QHIAQLQQQ...QNKMRLMQQQQQ.........EMQRIEQQR.RQQIMQQQQ.QQ.QQQE.HQRQQMLLQQQQQQQQMQQHHQMNGGGQFATQA.HQQAAYMQ..Q..M..QRM...EQIRHQQQQAQQHQQAQQQHQQQAQHHQMGYGIPNGYP.QQMHMH.PPAYGAHHMPQPTAFANIN...................................
#=GR LAG3_CAEEL/23-490     SS    ................................................................................................................................................XXXXXXX...XXXXXXXXXXXXXXXXXXXXXX----SS--HHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHTHHHHHHHHHHHHH--XXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXX.X.XXXXXXXXXXXX.XXXXXXX.....XXXXXXX..XXXXX......XXXXXXXXXX.XXX.X..XXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...X.X.XXXXXXXXX...XXXXXXXXXXXX.........XXXXXXXXX.XXXXXXXXX.XX.XXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXX..X..X..XXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXX.XXXXXXXXXXXXXXXXXXX...................................
E9GBC6_DAPPU/110-221             .......................................................................................................................................rsstffydk-------...-------------------------------------------------------------------------------------------------------------.-----------------------.-.------------.-------.....-------..-----......----------.---.-..----------...-------------------------------------------------------------------------------------NLQLFQPNVESNKTGSGTS--SLSAGTEEP-S...-.E.QQKRQQEQQ...LKQLMVLEEQQA.........----AQVLK.QQQVIDQHE.RR.-QQE.HQRNQLKIIQDQQKQQEKQQG------------.--------..-..-..---...--------------------------------------.------.-------------------rkvttsaspvaa.......................
H2WH88_CAEJA/1-436               ................................................................................................................................................MKPSTSKtttTTSSPPPEEP---YVNNDLPNPDDEPMLSDMQGVLSSDEIHRQKSQLAYAKFVKTQPEMIADQRIVTAQLFHRYSEEEERKRIEQQKNKEAINATTP---VSRNG-QVT.DNRKRRNE-AVPTLTSEEEWKRS.-.---WMGQQHGFRvQQQQQQQ.....QFQHHQQ..YMMMQ......QQQQQQFAMQlHPN.H..QMPSTSSADSvhsIHSVPTP-ASINQTSPG-MNPSS-------M---------DYRVMNEENLSVPEGEWFDKLAMAVAEQYNVDTVLGPDTYDV-LSELDCTDV-----KSPAF--PDRLPSAPPPPSS...T.Q.QQQLQLQQQqqeQNKLRMLQQQQQ.........-MQAMEEQR.QRQIQQQQH.QQ.-RMI.MQRQQMQQ-QQQMNGQFPSPNQQQ----QQQQQ.QQQAAYIQ..QmrM..QQM...RYQQQQQQQQQHHQQQQQQHPH-QQHQMMGYGMPTGGGgGGATTY.PPQMHMHHQAYMPAFANMN...................................
G0PAI3_CAEBE/1-267               ................................................................................................................................................MKPSTSK...VSVDPIPEEPSAEYVNNNLPNPDDEPYVSEIRDDQAVEELYRQQSQLAKERYAIALPEMINVNREGTAELFTRFTEDEERKKAEMQKNNEAMAASAP-PLFRHSG----.DSRKRRND--VITQCDKQEWKRQ.QpQQQWMAQSQMQL.GFLMQHY.....PHVQQQEqeYMQMQm....aAQQQLHHGIQ.-MH.HnnQMPSTSTADS...ARSVHTL-ASIHQQSPMEGRNVNRMAPSRNGINSISPTTGLDQQTDENTLAVPEGDWFEKLEVTPA---------------------------------------------------...-.-.---------...------------.........---------.---------.--.----.---------------------------------.--------..-..-..---...--------------------------------------.------.-------------------ngivngva...........................
C1C552_DROME/236-381             ........................................................................................................................................ppaglppq-------...-------------------------------------------------------------------------------------------------------------.-----------------------.-.------------.-------.....-------..-----......----------.---.-..----------...---------------------------------------------------------------------------------------------------------------YTPP-C...A.P.QQQQLLQQQ...QEQHRFLQQQQL.........QLQILQQQRlQQQVLQQQQ.LQ.QQVQvQHPQQLQL--SQQQQQLQQELPLI-SDQYQTTSfQPHAVTLK..D..YdaQTL...QQF-----------------------------------.------.-------------------ggqldlccassfnqnhfylsspgfprtvlnyllpn
G0PAI6_CAEBE/1-253               ................................................................................................................................................MTQSKSK...VSVAPIPEEPSAEYVNNNLPNPDDEPYVSEIRDDQAVEELYRQQSQLAKERYAIALPEMINVNREGTAELFTRFTEDEERKKAEMQKNKEAMAASRQ------SG----.DSRKRRND--VIAQCDEQEWKRQpH.QQQWMAQSQMQQySYHVQQQ.....QYMQMQ-..MAPQQ......QQHHGIQ-MH.Q-N.N..QMPSTSTADS...ARPIHTP-ASIHQQSPMEGRKGNRMAPSGNEMNTSSPTTDLDKQTDENTLALPEGDWFEKLAVTPAD--------------------------------------------------...-.-.---------...------------.........---------.---------.--.----.---------------------------------.--------..-..-..---...--------------------------------------.------.-------------------gming..............................
G0N5R2_CAEBE/1-470               ................................................................................................................................................MKPSTSK..vSSVAPIPEEPSAEYVNNNLPDPDDEPFVSDMRDYLAGEELHRQQSQLAKERYARALPEMVNANRTVTAELFTRFTEDEERKKAEMQKNKEAMAASAT-PLSRHSG----.DSRKRRNDVMAQSAGEERKWQQH.Q.Q-QWMAQSQMQP.GFQMQQQmqmypHHVQQQQ..YMQMQmaaqqqQQHHEI----.QMH.HnnQMPSTSTADS...ARSVQTP-ASIHQQSPMEGRNGNRMAPSRSGMDTSSPTTGLDQQTDENTLAVPDGDWFEKLAVIVAGQYDVNTVLSQDIYDPILN---FAEDVPPANGMINGVA-----QQCPPPIQqlpT.P.QP-QQHHHQ...QQKMRMLQQQQQn......heEMQRMEHQR.HQQLLQAQQ.AQlAQQR.HQQQQMIL-QQQQMHQQQQQNQMNGG--FQSHA.QQQAAYLQaqR..M..HQMr.mQQHQQQQQQQQQLHHHHQQQQQHHQNGGMGYGMPNGYP.PQMMHHaAAAYG-HHIPQPTPFANIN...................................
G0NJW7_CAEBE/501-627             ........................................................................................................................................dvnvaqql-------...-------------------------------------------------------------------------------------------------------------.-----------------------.-.------------.-------.....-------..-----......----------.---.-..----------...----------------------------------------------------------------------------------------------------------------PPPIQqlpT.P.QP-QQHHHQ...QQMMRMMQQQEM.........--QRMEHQR.HQQLLQAQL.AQ.--QR.HQQQQMILQQQ-------PQHRMNGG--FQSHA.QQQAAYMQ..-..A..QRM...HQMRMQQH---HHQQQ----QQQHQNGGMGYGMPNGYP.------.-------------------pk.................................
Q9VLX5_DROME/230-375             ........................................................................................................................................ppaglppq-------...-------------------------------------------------------------------------------------------------------------.-----------------------.-.------------.-------.....-------..-----......----------.---.-..----------...---------------------------------------------------------------------------------------------------------------YTPP-C...A.P.QQQQLLQQQ...QEQHRFLQQQQL.........QLQILQQQRlQQQVLQQQQ.LQ.QQVQvQHPQQLQL--SQQQQQLQQELPLI-SDQYQTTSfQPHAVTLK..D..YdaQTL...QQF-----------------------------------.------.-------------------ggqldlccassfnqnhfylsspgfprtvlnyllpn
G0PAI6_CAEBE/245-386             ......................................................................................................................................tpadgmingv-------...-------------------------------------------------------------------------------------------------------------.-----------------------.-.------------.-------.....-------..-----......----------.---.-..----------...------------------------------------------------------------------------------------------------------------AQQLPPPIQ...QlPtLQPQQHHQQ...QEKMRMLQQQEL.........--QRMEHQR.HQELLQAQL.AQ.--QR.HQQQQMILQQQ-------QQHQMNGG--FQSHA.QQQAAYMQaqR..M..HQM...RMQQHQQQQQLHHHQQ----QQHHQNGGMGYGMPPKM-.------.-------------------mqpkkp.............................
G0NK02_CAEBE/253-380             ....................................................................................................................................dgmingvaqqlp-------...-------------------------------------------------------------------------------------------------------------.-----------------------.-.------------.-------.....-------..-----......----------.---.-..----------...---------------------------------------------------------------------------------------------------------------------...-.-.PPIQQLTTP...QPQ---QQQSHE.........EMQKMEHQR.HQQLLQQAQ.LA.-QQR.HQ--------QQQMHQQQQQHQMNGGFQL--HA.QQQDAYMQalR..M..HQM...RLQQHQQQQQLHHRQQQ---QQHHQNGGMGYGMPNGYP.------.-------------------pk.................................
#=GC SS_cons                     ................................................................................................................................................XXXXXXX...XXXXXXXXXXXXXXXXXXXXXX----SS--HHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHTHHHHHHHHHHHHH--XXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXX.X.XXXXXXXXXXXX.XXXXXXX.....XXXXXXX..XXXXX......XXXXXXXXXX.XXX.X..XXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...X.X.XXXXXXXXX...XXXXXXXXXXXX.........XXXXXXXXX.XXXXXXXXX.XX.XXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXX..X..X..XXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXX.XXXXXXXXXXXXXXXXXXX...................................
#=GC seq_cons                    .............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t..ppQ...QpphhhhQQQp............p.hppQR.pQQh.Qtp...Q....p.pp.QQh....p.......ppt..........pt...psshhp.....h..pph...p...................................................................................................
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