GenomeNet

Database: Pfam
Entry: Activator_LAG-3
LinkDB: Activator_LAG-3
Original site: Activator_LAG-3 
#=GF ID   Activator_LAG-3
#=GF AC   PF11498.4
#=GF DE   Transcriptional activator LAG-3
#=GF AU   Pollington J
#=GF SE   pdb_2fo1
#=GF GA   23.30 23.30;
#=GF TC   23.30 23.30;
#=GF NC   23.10 23.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Transcriptional_activator_LAG-3
#=GF RN   [1]
#=GF RM   10830967
#=GF RT   LAG-3 is a putative transcriptional activator in the C. elegans
#=GF RT   Notch pathway. 
#=GF RA   Petcherski AG, Kimble J; 
#=GF RL   Nature. 2000;405:364-368.
#=GF DR   INTERPRO; IPR021587;
#=GF CC   The C.elegans Notch pathway, involved in the control of growth,
#=GF CC   differentiation and patterning in animal development, relies on
#=GF CC   either of the receptors GLP-1 or LIN-12 [1]. Both these
#=GF CC   receptors promote signalling by the recruitment of LAG-3 to
#=GF CC   target promoters, where it then acts as a transcriptional
#=GF CC   activator. LAG-3 works as a ternary complex together with the
#=GF CC   DNA binding protein, LAG-1 [1].
#=GF SQ   40
#=GS K7H759_CAEJA/20-455     AC K7H759.1
#=GS K7H760_CAEJA/16-451     AC K7H760.1
#=GS U6H104_9EIME/274-493    AC U6H104.1
#=GS G0PAI6_CAEBE/1-253      AC G0PAI6.1
#=GS A0A016VCG0_9BILA/8-147  AC A0A016VCG0.1
#=GS U6G636_9EIME/115-344    AC U6G636.1
#=GS U6MEF1_9EIME/1125-1354  AC U6MEF1.1
#=GS E9GBC6_DAPPU/18-221     AC E9GBC6.1
#=GS T1FUZ8_HELRO/402-587    AC T1FUZ8.1
#=GS U6MTV8_9EIME/43-181     AC U6MTV8.1
#=GS U6M5A3_EIMMA/187-386    AC U6M5A3.1
#=GS G0NJW7_CAEBE/246-507    AC G0NJW7.1
#=GS S2JU20_MUCC1/608-823    AC S2JU20.1
#=GS G0NK02_CAEBE/1-265      AC G0NK02.1
#=GS G0PAI3_CAEBE/257-396    AC G0PAI3.1
#=GS LAG3_CAEEL/23-490       AC Q09260.2
#=GS LAG3_CAEEL/23-490       DR PDB; 2FO1 D; 52-114;
#=GS G0PAI3_CAEBE/1-267      AC G0PAI3.1
#=GS U6MQG8_9EIME/29-203     AC U6MQG8.1
#=GS U6K0B8_9EIME/1178-1358  AC U6K0B8.1
#=GS U6G5H1_9EIME/108-339    AC U6G5H1.1
#=GS G0PAI6_CAEBE/245-386    AC G0PAI6.1
#=GS G0NK02_CAEBE/253-380    AC G0NK02.1
#=GS U6JWX4_9EIME/420-621    AC U6JWX4.1
#=GS W2SSG0_NECAM/4-156      AC W2SSG0.1
#=GS U6GXV0_9EIME/24-177     AC U6GXV0.1
#=GS A8X9K8_CAEBR/1-408      AC A8X9K8.1
#=GS U6LWS2_9EIME/595-783    AC U6LWS2.1
#=GS U6G7R7_9EIME/95-300     AC U6G7R7.1
#=GS G0NJW7_CAEBE/501-627    AC G0NJW7.1
#=GS E3LT94_CAERE/1-429      AC E3LT94.1
#=GS D3B9N7_POLPA/497-706    AC D3B9N7.1
#=GS U6GKU8_EIMAC/888-1107   AC U6GKU8.1
#=GS U6GCH2_EIMAC/422-652    AC U6GCH2.1
#=GS U6LB49_9EIME/72-260     AC U6LB49.1
#=GS C1C552_DROME/236-381    AC C1C552.1
#=GS K7HTC3_CAEJA/1-209      AC K7HTC3.1
#=GS K7H761_CAEJA/41-476     AC K7H761.1
#=GS U6JPU8_9EIME/306-480    AC U6JPU8.1
#=GS G0N5R2_CAEBE/1-470      AC G0N5R2.1
#=GS Q9VLX5_DROME/230-375    AC Q9VLX5.4
K7H759_CAEJA/20-455                ................................................................................................................................................MKPSTSKtttTTSSPPPEEP---YVNNDLPNPDDEPMLSDMQGVLSSDEIHRQKSQLAYAKFVKTQPEMIADQRIVTAQLFHRYSEEEERKRIEQ.QKNKEAINAT.T.P---VSRNG-QV..T.DNRKRRNE-AVPTLTSEEEWKRS.-.---WMGQQHGFRvQQQQQQQ.....QFQHHQQ..YMMMQ......QQQQQQFAMQlHPN..H..QMPSTSSADSvhsIHS.VPTP-ASINQTS.PG-MNPSS---.----M....---------DYRVMNEENL.....SVPEGEW....FDK....LAMAVAEQYNVDTVLGPDTYDV-LSELDCTDV-----KSPAF--P........DRLPSA.PPPP.....S...S...T.Q..QQQ..LQLQQ..QqqeQN.KL.RMLQQQQQ.........-MQAME..E.QR.Q.RQI.QQQQH.QQ.-RMI.M.QR.......QQMQQ-QQQM..NGQ....FPSPNQQQ...----QQQQQ.QQQAAYIQ..QmrM..QQM...RYQQQQQQQQQHHQQQQQQHPH-QQHQMMGYGMPTGGGgGGATTY.PPQMHMHHQAYMPAFANMN....................................
K7H760_CAEJA/16-451                ................................................................................................................................................MKPSTSKtttTTSSPPPEEP---YVNNDLPNPDDEPMLSDMQGVLSSDEIHRQKSQLAYAKFVKTQPEMIADQRIVTAQLFHRYSEEEERKRIEQ.QKNKEAINAT.T.P---VSRNG-QV..T.DNRKRRNE-AVPTLTSEEEWKRS.-.---WMGQQHGFRvQQQQQQQ.....QFQHHQQ..YMMMQ......QQQQQQFAMQlHPN..H..QMPSTSSADSvhsIHS.VPTP-ASINQTS.PG-MNPSS---.----M....---------DYRVMNEENL.....SVPEGEW....FDK....LAMAVAEQYNVDTVLGPDTYDV-LSELDCTDV-----KSPAF--P........DRLPSA.PPPP.....S...S...T.Q..QQQ..LQLQQ..QqqeQN.KL.RMLQQQQQ.........-MQAME..E.QR.Q.RQI.QQQQH.QQ.-RMI.M.QR.......QQMQQ-QQQM..NGQ....FPSPNQQQ...----QQQQQ.QQQAAYIQ..QmrM..QQM...RYQQQQQQQQQHHQQQQQQHPH-QQHQMMGYGMPTGGGgGGATTY.PPQMHMHHQAYMPAFANMN....................................
U6H104_9EIME/274-493               ..................................................akmdsaaaaaaaadaaaaaadaaaadaaaaagqhatvyaveaaadataaadaaaaanaaaataaaaaaaareeaetadaaaaadaaataaadae-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.-------.....-------..-----......----------.---..-..----------...---.------------.-----------.-----....-------------------.....-------....---....------------------AATVAAAAADAAAATAATAATAATAAA........AAAADA.AAEP.....K...E...N.Q..QQE..QQQQQ..E...QQ.QQqEQQQQQEQ.........-----E..Q.QH.KyEQE.EQQQQ.QQ.QQQQ.Q.QQ.......QQQQEEQQQE..RRQ....QQQQQQIN...KEDP-----.--------..-..-..---...--------------------------------------.------.-------------------lstepaaaaapaaaa.....................
G0PAI6_CAEBE/1-253                 ................................................................................................................................................MTQSKSK...VSVAPIPEEPSAEYVNNNLPNPDDEPYVSEIRDDQAVEELYRQQSQLAKERYAIALPEMINVNREGTAELFTRFTEDEERKKAEM.QKNKEAMAAS.R.Q------SG---..-.DSRKRRND--VIAQCDEQEWKRQpH.QQQWMAQSQMQQySYHVQQQ.....QYMQMQ-..MAPQQ......QQHHGIQ-MH.Q-N..N..QMPSTSTADS...ARP.IHTP-ASIHQQS.PMEGRKGNRMA.PSGNE....MNTSSPTTDLDKQTDENTL.....ALPEGDW....FEK....LAVTPAD--------------------------------------........------.----.....-...-...-.-..---..-----..-...--.--.--------.........------..-.--.-.---.-----.--.----.-.--.......----------..---....--------...---------.--------..-..-..---...--------------------------------------.------.-------------------gming...............................
A0A016VCG0_9BILA/8-147             ............................................................................................................................gqspsstlngnastpdppvp-------...---------------------------SSDGDRLRASMEAWKRSAALASERYGEARQRQIAAERDDRQELRKRWLEEEAKKRAESvGKHKDVMSTN.T.LTPNMPPPLYQStpI.NNRDSRKRHLDTNDYGHEEWRQG.-.------------.-------.....-------..-----......----------.---..-..----------...---.------------.-----------.-----....-------------------.....-------....---....---------------------------------------------........------.----.....-...-...-.-..---..-----..-...--.--.--------.........------..-.--.-.---.-----.--.----.-.--.......----------..---....--------...---------.--------..-..-..---...--------------------------------------.------.-------------------frmmegcgmsdm........................
U6G636_9EIME/115-344               ...................aaaaaaaaqetalaadaaldapsatpkdgvhnhcssssssrgycsssssssrgcdgsslafpaffeasnctdvaaaantaaatpgaattaaaaaaaatgagaaaaaatgaaaataaamispsgsp-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.-------.....-------..-----......----------.---..-..----------...---.------------.-----------.-----....-------------------.....-------....---....---------------------------------------------........--SNDA.AAQQ.....QrlrQ...Q.Q..QHL..EQQQQllQ...EE.RL.RLQQQERD.........QRQQIA..E.QL.Q.QLQ.LQQQQ.QQ.RLNA.RlRK.......QILLLQEQQQlqQQQ....LQQQQ-PS...EKRRFAAA-.--------..-..-..---...--------------------------------------.------.-------------------aetspsgaa...........................
U6MEF1_9EIME/1125-1354             .......................................................................................................................................cpacsplll-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.--QQQQQ.....QQ-QQQQ..LLLLQ......QQQQEYVRCK.DSK..-..-CCSSSSKSS...SNSnCSSSCSSSSSNS.SSSSNSHTGSS.SNSTK....GTVLAAVAAGATAAAAAAA.....AAAAAAAaaagAAA....AAAAAAAAAAAATAVAATTAAT-TADAAAADTATAAVATTAATTA........AAAAAA.AAAA.....A...A...A.A..TGT..EQMQQ..Q...Q-.--.--MQQQKQ.........QMQQQQ..Q.QL.Q.QQQ.LQQQQ.LQ.-QQQ.T.QQ.......QQMLNLAAKQ..IQ-....--------...---------.--------..-..-..---...--------------------------------------.------.-------------------fflfyk..............................
E9GBC6_DAPPU/18-221                ......................................................................................algvlswsvnpalgavrrppnyhhdhmpetsftcagkvvggyyadpdadcqmfhvcvq-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.-------.....-------..-----......----------.---..-..----------...---.------------.-----------.-----....-------------VDENDVrdfkfMCPNDTV....FDQ....ENFICANWFEIDCRSSTFFYDK---NLQLFQPNVESNKTGSGTS-........-SLSAG.TEEP.....-...S...E.Q..QK-..RQQEQ..Q...LK.QL.MVLEEQQA.........-AQ---..V.LK.Q.QQV.IDQHE.RR.-QQE.H.QR.......NQLKIIQDQQ..KQQ....EKQQG---...---------.--------..-..-..---...--------------------------------------.------.-------------------rkvttsaspvaa........................
T1FUZ8_HELRO/402-587               .....................................................................................................................................kvskvgtnstv-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.-------.....-------..-----......----------.---..-..----TTTAAT...ISS.SPTISVSASSGSaPGHMISSINNI.NTLVG....NVISVPLNSGNNSNNNNIS.....STNNSNS....SNN....NNLLGISADPTNVIIVSDSNIILTNNLLSNLVSNFTYHLPIESS-........-GFPQQ.QQQQ.....Q...Q...L.Q..QH-..QQLQQ..Q...Q-.--.QLLQQQQL.........-LQQ-Q..Q.QQ.Q.QQL.LQQQQ.QQ.QQQQ.-.--.......QQV-------..---....--------...---------.--------..-..-..---...--------------------------------------.------.-------------------innqviise...........................
U6MTV8_9EIME/43-181                ...............................................................................................inekcfskenflshdagydslltaviflnqigcvarekrigwadlyfrs-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.-------.....-------..-----......----------.---..-..----------...---.------------.-----------.-----....-------------------.....-------....---....---------------------------------------------........------.PAPS.....S...T...S.P..KVSasELLAA..A...AN.RV.RLVRTQPPf.......iHLEPPD..S.QQ.Q.QQQ.QQQQQ.QP.QQQD.R.DQ.......QQHLAQQQQQ..QQQ....QQQQQQQE...D--------.--------..-..-..---...--------------------------------------.------.-------------------rltfamvd............................
U6M5A3_EIMMA/187-386               .........................................................................devsvhlkppgftldaacsssssssnssssssssmeypfvsvsskgdilfsskdlncppqknlifkalnff-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.-------.....-------..-----......----------.---..-..----------...---.------------.-----------.-----....-------------------.....-------....---....---------------------------------------------........------.----.....-...-...-.-..---..-----..-...--.--.--------.........------..-.--.R.QYC.MQQQQ.QQ.QQQQ.V.QQ.......QQQQQQQQQQ..QVQfvvhLKKKIPMEaglGGGSSNAAA.VLHAADLL.lT..K..GQY...SQQQQQQQQLQQQQQLQQQQQLQQQQLSM---------.------.-------------------drvaadfsreatqlssssapppaaaapaatq.....
G0NJW7_CAEBE/246-507               ................................................................................................................................................MKPLTSK...VSVAPISEEPLTKYVNYNLPNPDDEPYVSDMHNYQAGEELHCQQSQLAKERYTIALPEMIDANRGVFAELFTRFTEDDKRKKAEM.QKNKEAMAAS.A.P-PLFRHSG---..-.DSRKRRNDVMV--ESAEEEWKRQpH.QQQWMVQSQMQQyPHHVQQQ.....QYMQMQ-..---MA......AQQQQHQGIQ.MHH.nN..QMPSTTTADS...ARS.VHTP-ASIYQQS.PMEGRNGNRMA.PSGSG....MNTDSPTSGSDQQTDENTL.....AFPEGDW....FEK....LKVTVAEPDDVN---------------------------------........------.----.....-...-...-.-..---..-----..-...--.--.--------.........------..-.--.-.---.-----.--.----.-.--.......----------..---....--------...---------.--------..-..-..---...--------------------------------------.------.-------------------vaqq................................
S2JU20_MUCC1/608-823               ...........................................................................................................................nhvealaillsqltdsgnnsk-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.-------.....-------..-----......----------.---..-..-IPSLSSSPC...IEK.HLRKSHVPPSPS.PSSSSDVAAAT.QTTAV....TLASAMPSNNVSTQFDNN-.....MVPNE--....---....-LLMVAES---SFSLVPSAAKTMLDHLASAPP--PSVISRLDIDR........EQLEKL.SRKP.....P...T...S.S..RQ-..QQLSH..H...QQiQQ.QMHQQRQQ.........-YQQYQ..QyQH.Y.QQQ.QQQQQ.QQ.QQQQ.Q.QQ.......QQFLLQQQKH.gLNQ....FNLQHQ--...---------.--------..-..-..---...--------------------------------------.------.-------------------sgsdylfskyv.........................
G0NK02_CAEBE/1-265                 ................................................................................................................................................MKPSTSK...VSVAPIPEKPLTKYVNYNLPNPDDEPYVSDMRNYQAGEELHREQSQLAKEKYTIALPEMINANRGVSAELFTRFTEDEKRKKAEM.QKNKDAMAAS.A.A-PLSRHSG---..-.DSRKRRND--VMAQSAEEEWKRQpH.QQQWLAQSQMQQyPHHVQQH.....YYMQMQ-..MAAQQ......QQHHGIQ-M-.HHN..N..QMPSTSTADS...ARS.VHTP-ALIHQQS.PIEGRNGNKMA.PSRSG....MNTSSPTTDLDQQTDENTL.....AVPEEDW....FEN....LAVTPAD--------------------------------------........------.----.....-...-...-.-..---..-----..-...--.--.--------.........------..-.--.-.---.-----.--.----.-.--.......----------..---....--------...---------.--------..-..-..---...--------------------------------------.------.-------------------gmingvaqqlpp........................
G0PAI3_CAEBE/257-396               ...................................................................................................................................tpangivngvaqq-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.-------.....-------..-----......----------.---..-..----------...---.------------.-----------.-----....-------------------.....-------....---....---------------------------------------------........------.IPSP.....I...QrlpT.P..QP-..QQHDQ..Q...QQ.KM.RMLQQQEM.........--QRME..H.QR.H.QQL.LQAQL.AQ.--QR.H.QQ.......QQMILQQQ--..---....--PQHQMN...GGFQL--HA.QQQAAYMQ..-..A..QRM...HQMRMQQHQQQQQLHRHQQQQHHHQNGGMGYDMPNGYP.H-----.-------------------k...................................
LAG3_CAEEL/23-490                  ................................................................................................................................................MKPSTSK...TTHSPPPEEPTAPFVNDNLPNPEDEPTIGDLNAFHSGEELHRQRSELARANYEKARPEMIANQRAVTAHLFNRYTEDEERKRVEQ.QKNKEAMNAS.T.SAPTSSRNGGQS..V.ENRKRRNDVVVAPPTSEEEWKRA.Q.QQHWMGQQQPQM.QFQMQQQ.....YHSQQQQ..YIMMQ......QQHHHMTGMQ.QIH..H..QMPSTSSADS...IRS.VPTPASSMHQPS.PAEMRNGCGMS.RNATM....DMTCSPMSGGQPIVDENNL.....AVPEGEW....FDK....LALAVAEQYNVDTILGPDTYDTFLAELDFSSSESPTKQSPMEMNG........DRMPST.APPP.....A...Q...N.P..QHI..AQLQQ..Q...QN.KM.RLMQQQQQ.........EMQRIE..Q.QR.R.QQI.MQQQQ.QQ.QQQE.H.QR.......QQMLLQQQQQ..QQQ....MQQHHQMN...GGGQFATQA.HQQAAYMQ..Q..M..QRM...EQIRHQQQQAQQHQQAQQQHQQQAQHHQMGYGIPNGYP.QQMHMH.PPAYGAHHMPQPTAFANIN....................................
#=GR LAG3_CAEEL/23-490       SS    ................................................................................................................................................XXXXXXX...XXXXXXXXXXXXXXXXXXXXXX----SS--HHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHTHHHHHHHHHHHHH--.XXXXXXXXXX.X.XXXXXXXXXXXX..X.XXXXXXXXXXXXXXXXXXXXXXX.X.XXXXXXXXXXXX.XXXXXXX.....XXXXXXX..XXXXX......XXXXXXXXXX.XXX..X..XXXXXXXXXX...XXX.XXXXXXXXXXXX.XXXXXXXXXXX.XXXXX....XXXXXXXXXXXXXXXXXXX.....XXXXXXX....XXX....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX........XXXXXX.XXXX.....X...X...X.X..XXX..XXXXX..X...XX.XX.XXXXXXXX.........XXXXXX..X.XX.X.XXX.XXXXX.XX.XXXX.X.XX.......XXXXXXXXXX..XXX....XXXXXXXX...XXXXXXXXX.XXXXXXXX..X..X..XXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXX.XXXXXXXXXXXXXXXXXXX....................................
G0PAI3_CAEBE/1-267                 ................................................................................................................................................MKPSTSK...VSVDPIPEEPSAEYVNNNLPNPDDEPYVSEIRDDQAVEELYRQQSQLAKERYAIALPEMINVNREGTAELFTRFTEDEERKKAEM.QKNNEAMAAS.A.P-PLFRHSG---..-.DSRKRRND--VITQCDKQEWKRQ.QpQQQWMAQSQMQL.GFLMQHY.....PHVQQQEqeYMQMQm....aAQQQLHHGIQ.-MH..HnnQMPSTSTADS...ARS.VHTL-ASIHQQS.PMEGRNVNRMA.PSRNG....INSISPTTGLDQQTDENTL.....AVPEGDW....FEK....LEVTPA---------------------------------------........------.----.....-...-...-.-..---..-----..-...--.--.--------.........------..-.--.-.---.-----.--.----.-.--.......----------..---....--------...---------.--------..-..-..---...--------------------------------------.------.-------------------ngivngva............................
U6MQG8_9EIME/29-203                ......................................................................................................................................tllcpvaskt-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.-------.....-------..-----......----------.---..-..----------...---.------------.-----------.-----....-------------------.....-------....---....--------------------------LNFSVHKSHNAAAAAAAAA........AAAAAA.AAEP.....A...L...A.A..AHK..QQLQH..E...QL.QLeKKLQQQQR.........QLQQLQ..Q.QQ.L.QLQ.LQQQK.LQ.QHKQ.Q.L-.......QQQQLQQQQQ..QQQ....QQQQQQPL...PEGFYNSAA.DAKLAELH..T..E..GRY...RVFAHLRRQVG---------------------------.------.-------------------apqkallrgpsgdtevtlwcsndylgmsqh......
U6K0B8_9EIME/1178-1358             .........................................................................................staatdaaapspaaaaaaaaaaaaaaaaaaakrkslafkysplpkrpdpehfvsv-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.-------.....-------..-----......----------.---..-..----------...---.------------.-----------.-----....-------------------.....-------....---....---------------------------------------------........------.----.....-...-...-.-..---..-----..-...--.--.--------.........----LS..S.SK.K.RKL.LQQQQ.QQ.QQQQ.Q.GL.......KQPLQQQQQQ..QQQ....EQQQQQQQ...QQGDLPSSS.HSAAAGLS..K..P..-SI...EQQEQQQQQQQQEQQQQQQQQQTESDAAATSGSPASS-.------.-------------------sqvgaaaaaagtttaaaaaaaaaa............
U6G5H1_9EIME/108-339               ................................................................................................................................dswpgsqqqqssssss-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.-------.....-------..-----......----------.---..-..--SSNSSSSS...SNS.IDA--GSSANSS.SSSSSSSS-RS.SAAIIkfreHLKDAMMTAGLSDGKETIL.....LINDRQI....LDEeilaYADAIANTGEVQGLLDADAVEMIVSDLTSSAAARDMINNSSSSSSsssssnstETLSAVaAHLF.....A...A...D.T..TLL..LQLQQ..Q...QQqQQ.QLMQQQQQ.........-QQQQE..P.QQ.N.QQE.QQQQQ.QE.QQQE.Q.QQ.......QQQQ------..---....QQQQQ---...---------.--------..-..-..---...--------------------------------------.------.-------------------hinklsklcvdihlsaea..................
G0PAI6_CAEBE/245-386               ......................................................................................................................................tpadgmingv-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.-------.....-------..-----......----------.---..-..----------...---.------------.-----------.-----....-------------------.....-------....---....---------------------------------------------........---AQQ.LPPP.....I...Q...QlP.tLQP..QQHHQ..Q...QE.KM.RMLQQQEL.........--QRME..H.QR.H.QEL.LQAQL.AQ.--QR.H.QQ.......QQMILQQQ--..---....--QQHQMN...GG--FQSHA.QQQAAYMQaqR..M..HQM...RMQQHQQQQQLHHHQQ----QQHHQNGGMGYGMPPKM-.------.-------------------mqpkkp..............................
G0NK02_CAEBE/253-380               ....................................................................................................................................dgmingvaqqlp-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.-------.....-------..-----......----------.---..-..----------...---.------------.-----------.-----....-------------------.....-------....---....---------------------------------------------........------.----.....-...-...-.-..PPI..QQLTT..P...QP.Q-.--QQQSHE.........EMQKME..H.QR.H.QQL.LQQAQ.LA.-QQR.H.Q-.......-------QQQ..MHQ....QQQQHQMN...GGFQL--HA.QQQDAYMQalR..M..HQM...RLQQHQQQQQLHHRQQQ---QQHHQNGGMGYGMPNGYP.------.-------------------pk..................................
U6JWX4_9EIME/420-621               ................................................................................................................................vaapscvlvgvritgl-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.-------.....-------..-----......----------.---..-..----------...---.---PAAIDRRSS.MSACQASCRAA.QQLAA....A-AAAAAAAADAAAIEKIK.....HVPQPCH....FIS....FNIKNNFCYKFVSLALTQTAATYIST-SANCPISAAVAAAAAAA-........AAAADT.NSQA.....T...T...L.N..EG-..AASST..Q...QQ.QM.MLMQMQQQ.........------..Q.QQ.Q.QQQ.MQQQL.QL.QQQQ.Q.QQ.......QMMMMMQQQQ..QDP....MLE-----...---------.--------..-..-..---...--------------------------------------.------.-------------------gnahdvvgelfnflfpaaa.................
W2SSG0_NECAM/4-156                 ........................................................................................................................................ammpgqsp-------...-----------SSTLNGNASTPDPPVPTSDGDRLRASMEAWKRSAAVASERYGEARQRQIAAERDDRQELRKRWLEEEAKKRAENvGKHKDGMSNNlTsSMPPPL-YQSTP..I.NNRDNRKRHLDTNDYGHEEWRQG.-.------------.-------.....-------..-----......----------.---..-..----------...---.------------.-----------.-----....-------------------.....-------....---....---------------------------------------------........------.----.....-...-...-.-..---..-----..-...--.--.--------.........------..-.--.-.---.-----.--.----.-.--.......----------..---....--------...---------.--------..-..-..---...--------------------------------------.------.-------------------frmmegcgmpdmsktstdmysn..............
U6GXV0_9EIME/24-177                ................................................................................................dnpenevvsvivsesearneekpeidstvstdegnddddeaddeeaef-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.-------.....-------..-----......----------.---..-..----------...---.------------.-----------.-----....-------------------.....-------....---....---------------------------------------------........------.----.....-...-...-.-..---..TRTRD..R...EY.KK.REIQQQQQ.........Q-QQEQ..Q.QV.L.QQQ.LQLHQ.HI.QQEE.E.AQ.......QQLLQIKQQQ..QQQ....QQQQQQRR...RSGYV----.--------..-..-..---...--------------------------------------.------.-------------------scryssaaaaartatstaataaaaaahtagrrspaa
A8X9K8_CAEBR/1-408                 ................................................................................................................................................MKPSTSKagsSAQSPPPEEPNSAYVNNELPDPDDEPLVSEMTVYNKGQEEARLRSQEAYEKFQKTRQESISSQRAVTAQLYHRFTEDEERKRMEH.QKNKEAMNAS.V.A--SASRNG--H..I.DNRKRRND--VGSLSAEEEWRRAqQ.QQHWMGQAAPMHpSYQMQQQ.....YH-QQQ-..---VA......AQHHQFM---.---..-..---------A...PHS.VPTP-GSIHRPS.PSGMQSVC---.-----....----------LPTSDENSL.....DVPNGEW....FDK....LAVMVAEKYDATTILGPDTYDVYLNELDAMEPVGETVKTPSEAG-........----QS.ASQP.....-...M...N.P..QQ-..QQMAQ..Q...QN.KM.RMLQQQEM.........----ME..Q.QR.Q.QQM.MHQHQ.QQ.----.H.RQ.......QQMLL-QQQQ..MHQ....LQQQNQMN...-GGQF-TQA.QQHAVYLQ..R..M..QHMrlqQQQQQQQQQAQHHQQA-QQHQQPHQNGVMGYSVPNGY-.AHPNGY.AP-YG-HHMPHHTPFANIN....................................
U6LWS2_9EIME/595-783               .............................................................aaeeslpspaasasyttpeaagaeaaavkaaaagaaaldagapaaaaaaaaadaadaadaadaaevaeavaeltaaeeaaaae-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.-------.....-------..-----......----------.---..-..----------...---.------------.-----------.-----....-------------------.....-------....---....----------------------------------EAAAIPAAATL........DMAPAA.AVKPppesaA...A...K.P..RS-..-PVYT..E...SR.AV.DWLIARQQ.........ELQQ-K..Q.QR.L.QQE.VQQRQ.QE.VQQL.L.QR.......RQLQL--QQR..MQQ....LQPK----...---------.--------..-..-..---...--------------------------------------.------.-------------------epkptyegglllptas....................
U6G7R7_9EIME/95-300                .................................................................................................ipsnleafeeieesrsssssnssssssssssssssktkgspslrgfl-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.-------.....-------..-----......----------.---..-..----------...---.------------.-----------.-----....-------------------.....---NASE....FEA....IAESVAEGIANSTSYGVRSITNPLAAAAA-AAAAAAKKTGVDASS........SPAAAAaAVAQ.....L...V...D.P..LNL..LQLQQ..Q...LA.AA.Y-EKQTDS.........AKQREQ..Q.QD.E.EQQ.QQQQQ.QQ.QQRE.D.ESstssteaETSLSQQQQQ..QQQ....QQQQDET-...---------.--------..-..-..---...--------------------------------------.------.-------------------ssnrsdasttaaatttatt.................
G0NJW7_CAEBE/501-627               ........................................................................................................................................dvnvaqql-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.-------.....-------..-----......----------.---..-..----------...---.------------.-----------.-----....-------------------.....-------....---....---------------------------------------------........------.-PPP.....I...QqlpT.P..QP-..QQHHH..Q...QQ.MM.RMMQQQEM.........--QRME..H.QR.H.QQL.LQAQL.AQ.--QR.H.QQ.......QQMILQQQ--..---....--PQHRMN...GG--FQSHA.QQQAAYMQ..-..A..QRM...HQMRMQQH---HHQQQ----QQQHQNGGMGYGMPNGYP.------.-------------------pk..................................
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U6GKU8_EIMAC/888-1107              .............................................................................................................................snsssnsnngssssssggs-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.-------.....-------..-----......----------.---..-..---------S...GSS.TSTSTSNSNSNS.NSSSSSSTSTSnSNSSS....SSTSTSNSSSSSSSSSSSS.....RVS-GGS....VSN....FSVSLSPQSYKDWLLGDRGV---GSEGDTSEETAEIVSSRVGCLG........SSRPLL.SAAD.....Q...M...L.PyiQYF..QQQQQ..Q...-Q.QQ.QHMQQQQT.........QQQEMQ..Q.QQ.Q.QQMmMHQDE.PQ.LQHE.L.QQe.....lQQVLQQQQQQ..QQQ....QQQQEDLL...LAGK-----.--------..-..-..---...--------------------------------------.------.-------------------ydlneet.............................
U6GCH2_EIMAC/422-652               ....................................ssssssksllqllpapfreaaaalaisggvsaaaaaaatpaaaaaagapgaeeaagsaaaeaaaattasadrgetaaaagvdgaaretaaaaaaeeegtaaaatapaa-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.-------.....-------..-----......----------.---..-..----------...---.------------.-----------.-----....-------------------.....-------....---....----------------------------------------AEAKG........SAAAAS.AQIN.....I...R...G.P..LKM..SRLLG..T...RR.RS.EVAAAAAA........aRSLRLLllR.QR.Q.QQ-.--QQE.QK.QQQE.H.KG.......SGMRLAAEQQ..QQQ....QQQQSSCS...SSDEWAALG.HP------..-..-..---...--------------------------------------.------.-------------------eacacssssssssnsssedeeqqe............
U6LB49_9EIME/72-260                .......vpqpwagptpnpapaapapaaaaaaaataaaaaaaaaaagesgdgsaaadkeesvdiaalllaaaeaadakaelqapaavsrgcrvvlaneeevfayakrnsllpdnkaksladinpaetarvistllkeyeaairq-------...-------------------------------------------------------------------------------------.----------.-.------------..-.-----------------------.-.------------.-------.....-------..-----......----------.---..-..----------...---.------------.-----------.-----....-------------------.....-------....---....---------------------------------------------........------.----.....-...-...-.-..---..-----..-...AK.AT.ALLQQQPQ.........------..Q.QQ.Q.QQQ.QQQQQ.QQ.QQPQ.Q.QQ.......QQQLLQLQQQ..Q--....--------...---------.--------..-..-..---...--------------------------------------.------.-------------------gaaaaggr............................
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#=GC SS_cons                       ................................................................................................................................................XXXXXXX...XXXXXXXXXXXXXXXXXXXXXX----SS--HHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHTHHHHHHHHHHHHH--.XXXXXXXXXX.X.XXXXXXXXXXXX..X.XXXXXXXXXXXXXXXXXXXXXXX.X.XXXXXXXXXXXX.XXXXXXX.....XXXXXXX..XXXXX......XXXXXXXXXX.XXX..X..XXXXXXXXXX...XXX.XXXXXXXXXXXX.XXXXXXXXXXX.XXXXX....XXXXXXXXXXXXXXXXXXX.....XXXXXXX....XXX....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX........XXXXXX.XXXX.....X...X...X.X..XXX..XXXXX..X...XX.XX.XXXXXXXX.........XXXXXX..X.XX.X.XXX.XXXXX.XX.XXXX.X.XX.......XXXXXXXXXX..XXX....XXXXXXXX...XXXXXXXXX.XXXXXXXX..X..X..XXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXX.XXXXXXXXXXXXXXXXXXX....................................
#=GC seq_cons                      .................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t....t.....p.pp..p...pp.p..thhQQpp............p..p..p.Qp.p.QQ...QQQp.tQ..ppp.p.pp.......QQ....tQQp...tQ......ppt........................................................................................................t..................................
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