GenomeNet

Database: Pfam
Entry: Adeno_E1B_55K_N
LinkDB: Adeno_E1B_55K_N
Original site: Adeno_E1B_55K_N 
#=GF ID   Adeno_E1B_55K_N
#=GF AC   PF04623.10
#=GF DE   Adenovirus E1B protein N-terminus
#=GF AU   Kerrison ND, Bashton M, Bateman A
#=GF SE   DOMO:DM04583;
#=GF GA   25.00 25.00;
#=GF TC   59.80 59.10;
#=GF NC   21.20 19.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10207064
#=GF RT   Corepressor required for adenovirus E1B 55,000-molecular-weight
#=GF RT   protein repression of basal transcription. 
#=GF RA   Martin ME, Berk AJ; 
#=GF RL   Mol Cell Biol 1999;19:3403-3414.
#=GF DR   INTERPRO; IPR006717;
#=GF CC   This family constitutes the amino termini of E1B 55 kDa
#=GF CC   (Pfam:PF01696). E1B 55K binds p53 the tumour suppressor protein
#=GF CC   converting it from a transcriptional activator which responds to
#=GF CC   damaged DNA in to an unregulated repressor of genes with a p53
#=GF CC   binding site [1]. This protects the virus against p53 induced
#=GF CC   host antiviral responses and prevents apoptosis as induced by
#=GF CC   the by the adenovirus E1A protein [1]. The role of the N
#=GF CC   terminus in the function of E1B is not known.
#=GF SQ   1
#=GS E1B55_ADE02/1-65  AC P03244.2
E1B55_ADE02/1-65             MERRNPSERGVPAGFSGHASVESGGETQE-------SPATVVFRPPGNNTDGGA-TAGGSQAaAAAGAEpMEP
#=GC seq_cons                MERRNPSERGVPAGFSGHASVESGGETQE.......SPATVVFRPPGNNTDGGA.TAGGSQAAAAAGAEPMEP
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