GenomeNet

Database: Pfam
Entry: Adeno_IVa2
LinkDB: Adeno_IVa2
Original site: Adeno_IVa2 
#=GF ID   Adeno_IVa2
#=GF AC   PF02456.14
#=GF DE   Adenovirus IVa2 protein
#=GF AU   Bateman A
#=GF SE   Pfam-B_1982 (release 5.4)
#=GF GA   20.10 20.10;
#=GF TC   20.10 20.10;
#=GF NC   20.00 19.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   10684284
#=GF RT   Interaction of the adenovirus IVa2 protein with viral packaging
#=GF RT   sequences. 
#=GF RA   Zhang W, Imperiale MJ; 
#=GF RL   J Virol 2000;74:2687-2693.
#=GF RN   [2]
#=GF RM   8207818
#=GF RT   The product of the adenovirus intermediate gene IVa2 is a
#=GF RT   transcriptional activator of the major late promoter. 
#=GF RA   Tribouley C, Lutz P, Staub A, Kedinger C; 
#=GF RL   J Virol 1994;68:4450-4457.
#=GF DR   INTERPRO; IPR003389;
#=GF CC   IVa2 protein can interact with the adenoviral packaging signal
#=GF CC   and that this interaction involves DNA sequences that have
#=GF CC   previously been demonstrated to be required for packaging [1].
#=GF CC   During the course of lytic infection, the adenovirus major late
#=GF CC   promoter (MLP) is induced to high levels after replication of
#=GF CC   viral DNA has started. IVa2 is a transcriptional activator of
#=GF CC   the major late promoter [2]. 
#=GF SQ   11
#=GS PKG1_ADE02/76-447      AC P03272.1
#=GS A0A087T4V4_9ARAC/3-65  AC A0A087T4V4.1
#=GS Q9III4_ADEF1/1-364     AC Q9III4.1
#=GS V3ZCB7_LOTGI/5-51      AC V3ZCB7.1
#=GS A0A158P4L7_TETUR/1-60  AC A0A158P4L7.1
#=GS A0A158P4P1_TETUR/1-48  AC A0A158P4P1.1
#=GS A0A087V0L9_9ARAC/3-45  AC A0A087V0L9.1
#=GS A0A158P4C4_TETUR/2-62  AC A0A158P4C4.1
#=GS Q83894_ADEO7/2-320     AC Q83894.2
#=GS R6CBC8_9FIRM/727-822   AC R6CBC8.1
#=GS PKG1_ADEG1/61-425      AC Q64749.1
PKG1_ADE02/76-447                 ...........................................................LDRDAVEHVTELWDRLELLG..QTLKSMPTADGL....KPLKNFASLQELLSLGGerLL.A.H.L...V.RENMQVRDMLNE.VAPL..LRDDG.SC.....S.S.L...NYQ..L.Q...P..V.IGV.IYGPTGCGKSQLLRNLL..S.SQ..LISPTPETVFFIAPQVDMIPPSEL....KAWEMQICEGNYAPGPDGTIIPQSGTLR.PRFVKMAYDDLILEHNYDVSDPRNIFAQAAARGPIAIIMDECMENLGGHKGVSKFFHAFPSKLHDKFPKCTGYTVLVVLHNMNPRRDMAGNIANLKIQSKMHLISPRMHPSQLNRFVNTYTKGLPLAI.SLLLKDIFRHHAQRSCYDWIIYNTTPQHEALQWC.YLHPRDGLMPMYLNIQSHLYHVLEKIHRTL....NDRDRWSRAYRARKT........................................................................................................................................................
A0A087T4V4_9ARAC/3-65             ........................................................wpm--------------------..------------....-----------------..--.-.-.-...-.------------.----..-----.--.....-.-.-...--L..K.H...P..S.TSL.ISGPTGSGKTHFVIRVI..E.ES..LLSPMPQRIIYCYGA---------....----------------------------.--------------------------------------------------------------------------------------------------------------------------------.----------------------------------.------------------------------....---------------yqsifskmknvqfqegl.......................................................................................................................................
Q9III4_ADEF1/1-364                ........................................................mdk-------RIEEFYNKIVEWK..NAVDRINRSILPecdlPPYRDFYSYE-------..ID.C.G.L...E.EYMNHFYGIQKL.NQKF..LSANG.EL.....S.S.L...NYG..L.N...P..F.IGI.ISGPTGTGKSQLIRNLI..S.NK..LISPPPETVIFITPTKGMLSPEET....NLWKLQLQEGNYEKNTDG-ICPITSVFS.VDFVEIDFETAVSPDNLDINNDKSCFVQAAKNGNVCIVIDECMKCLIDKRNISPLFCSLPSKISSKFK--TGFSMFVVLHNINPTSGNGNNIMDLKIQAKLHILSSKNAPFQLSRFVNTYGTGMSPQLkAVLMNSIIE--ESKNDYSFILFNVEPPRPGFSWCaLLNGGNCCEPLSLDLQSILLECVNKICAILkckkRNRERYVKEKKRKLE........................................................................................................................................................
V3ZCB7_LOTGI/5-51                 .......................................................talr--------------------..------------....-----------------..--.-.-.-...-.------------.----..-----.--.....-.-.-...---..-.H...P..F.TML.VSGPTGVGKTVFVQKLL..E.AN..MFDPVPERIVW-------------....----------------------------.--------------------------------------------------------------------------------------------------------------------------------.----------------------------------.------------------------------....---------------aygewq..................................................................................................................................................
A0A158P4L7_TETUR/1-60             ....................................................msisvhl--------------------..------------....-----------------..--.-.-.-...-.------------.----..-----.--.....-.-.-...---..K.H...P..F.TML.IAGPTGSGKTHFIRDMInkA.SQ..ICDPPPKSVTYLYG----------....----------------------------.--------------------------------------------------------------------------------------------------------------------------------.----------------------------------.------------------------------....---------------eyqkmfnsmp..............................................................................................................................................
A0A158P4P1_TETUR/1-48             ..........................................................m--------------------..------------....-----------------..--.-.-.-...-.------------.----..-----.--.....-.-.-...---..-.-...-..-.--L.IAGPTGSGKTHFIRDMInkA.SQ..ICDPPPKSVTYLYGE---------....----------------------------.--------------------------------------------------------------------------------------------------------------------------------.----------------------------------.------------------------------....---------------yqkmfnsmp...............................................................................................................................................
A0A087V0L9_9ARAC/3-45             .......................................................fpkl--------------------..------------....-----------------..--.-.-.-...-.------------.----..-----.--.....-.-.-...---..K.H...P..F.TMV.VAGPTSSGKTVFVKKLV..Q.HR..SIDPFPTKIV--------------....----------------------------.--------------------------------------------------------------------------------------------------------------------------------.----------------------------------.------------------------------....---------------wc......................................................................................................................................................
A0A158P4C4_TETUR/2-62             .......................................................syki--------------------..------------....-----------------..--.-.-.-...-.------------.----..-----.--.....-.-.-...-YL..R.H...P..F.TML.IAGPTGSGKTEFVRKLI..I.KRetICDPAPERIIYYYS----------....----------------------------.--------------------------------------------------------------------------------------------------------------------------------.----------------------------------.------------------------------....---------------eyqeifdsmlnv............................................................................................................................................
Q83894_ADEO7/2-320                .......................................................yhgq--------------------..------------....-----------------..LM.T.D.L...H.NIAVNYQKTVNE.AHNL..LKD-G.CI.....P.S.L...NCG..L.Q...P..F.IVT.VYGPTGSGKSQFIRNII..S.GK..LIDPIPETIFFITPEKGTVPLEEK....IAWKAQCVEGNYDAFS----NPLTKTLN.PKFIQLAFKDAISDTNLNIDNPDNIFCRAASEGSICIIIDECMNQLGSCHSISSFFHALPSKIFNRFAKCNGYTVVVVLHNMNPRHDR-GNIKDLKIQSKCHVISPQLDSSQINRFIKNYSFGFPSAL.IPVLKDIVDHARVNSKYSWLIYNNVPITESFRWS.YYSPSDQVKPIFMNLQSLFYQACMEIRRVF....RKRTYTQNQYVKRL-n.......................................................................................................................................................
R6CBC8_9FIRM/727-822              .......................................iegavdwdctipeevdqeea--------------------..------------....-----------------..--.-.-.-...-.------------.YLPV..TADAS.QL.....H.A.I...NMA..A.A...G..V.SFV.LHGPPGTGKSQTITALI..A.NA..LTK--GKTVLFVAEKRAALE----....----------------------------.--------------------------------------------------------------------------------------------------------------------------------.----------------------------------.------------------------------....---------------vvqkrlaalgiddf..........................................................................................................................................
PKG1_ADEG1/61-425                 ...........................................................YEEEEYEASRDFYQRVTSWY..DGAVDL--APQL....FREQHFPSYDEFYSLGG..VN.E.K.F...L.EAHEEVKAQEQM.DSRY..LQH-G.QL.....P.S.I...NMG..K.Q...P..I.IGV.IYGPTGSGKSHLLRALI..S.CN..MLDPIPETVIFITPEKNMIPPIEQ....TSWNLQLVEANFDCREDGTIAPKTSTFR.PEFMEMTYEEATAPEHLNIDHPDNIYVKVSKRGPVAIIMDECMDKLCSGSSVSVLFHALPSKLFARSAHCTAFYIFVVLHNMAPRTAI-GNVPTLKVNAKMHILSCHIPQFQFARFLYAFAHNISKDL.VVLLKAYFSFLQQNQRFSWVMYTPDPVSESFRWC.SIDQQYSIIPLNVNIQERFLKTAKSIIKF-....SETHRKQLERNPKLT........................................................................................................................................................
#=GC seq_cons                     ..........................................................h...................................................................................................................h.p...P..h.hhl.IuGPTGSGKopFlRsLI..u.sp..lhDPhPcollalhst.......................................................................................................................................................................................................................................................................................................................................................................................................................
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