GenomeNet

Database: Pfam
Entry: Adeno_IVa2
LinkDB: Adeno_IVa2
Original site: Adeno_IVa2 
#=GF ID   Adeno_IVa2
#=GF AC   PF02456.13
#=GF DE   Adenovirus IVa2 protein
#=GF AU   Bateman A
#=GF SE   Pfam-B_1982 (release 5.4)
#=GF GA   20.10 20.10;
#=GF TC   20.10 20.10;
#=GF NC   20.00 19.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   10684284
#=GF RT   Interaction of the adenovirus IVa2 protein with viral packaging
#=GF RT   sequences. 
#=GF RA   Zhang W, Imperiale MJ; 
#=GF RL   J Virol 2000;74:2687-2693.
#=GF RN   [2]
#=GF RM   8207818
#=GF RT   The product of the adenovirus intermediate gene IVa2 is a
#=GF RT   transcriptional activator of the major late promoter. 
#=GF RA   Tribouley C, Lutz P, Staub A, Kedinger C; 
#=GF RL   J Virol 1994;68:4450-4457.
#=GF DR   INTERPRO; IPR003389;
#=GF CC   IVa2 protein can interact with the adenoviral packaging signal
#=GF CC   and that this interaction involves DNA sequences that have
#=GF CC   previously been demonstrated to be required for packaging [1].
#=GF CC   During the course of lytic infection, the adenovirus major late
#=GF CC   promoter (MLP) is induced to high levels after replication of
#=GF CC   viral DNA has started. IVa2 is a transcriptional activator of
#=GF CC   the major late promoter [2]. 
#=GF SQ   6
#=GS PKG1_ADE02/76-447     AC P03272.1
#=GS Q9III4_ADEF1/1-364    AC Q9III4.1
#=GS V3ZCB7_LOTGI/5-51     AC V3ZCB7.1
#=GS Q83894_ADEO7/2-320    AC Q83894.2
#=GS R6CBC8_9FIRM/727-822  AC R6CBC8.1
#=GS PKG1_ADEG1/61-425     AC Q64749.1
PKG1_ADE02/76-447                ...........................................................LDRDAVEHVTELWDRLELLG..QTLKSMPTADGL....KPLKNFASLQELLSLGGerLLA.H.L...V.RENMQVRDMLNE.VAPL..LRDDG.SC.....S.SL...NYQ..L.Q...P..V.IGV.IYGPTGCGKSQLLRNLLS.SQLISPTPETVFFIA..PQVDMIPPSEL....KAWEMQICEGNYAPGPDGTIIPQSGTLR.PRFVKMAYDDLILEHNYDVSDPRNIFAQAAARGPIAIIMDECMENLGGHKGVSKFFHAFPSKLHDKFPKCTGYTVLVVLHNMNPRRDMAGNIANLKIQSKMHLISPRMHPSQLNRFVNTYTKGLPLAI.SLLLKDIFRHHAQRSCYDWIIYNTTPQHEALQWC.YLHPRDGLMPMYLNIQSHLYHVLEKIHRTL....NDRDRWSRAYRARKT........................................................................................................................................................
Q9III4_ADEF1/1-364               ........................................................mdk-------RIEEFYNKIVEWK..NAVDRINRSILPecdlPPYRDFYSYE-------..IDC.G.L...E.EYMNHFYGIQKL.NQKF..LSANG.EL.....S.SL...NYG..L.N...P..F.IGI.ISGPTGTGKSQLIRNLIS.NKLISPPPETVIFIT..PTKGMLSPEET....NLWKLQLQEGNYEKNTDG-ICPITSVFS.VDFVEIDFETAVSPDNLDINNDKSCFVQAAKNGNVCIVIDECMKCLIDKRNISPLFCSLPSKISSKFK--TGFSMFVVLHNINPTSGNGNNIMDLKIQAKLHILSSKNAPFQLSRFVNTYGTGMSPQLkAVLMNSIIE--ESKNDYSFILFNVEPPRPGFSWCaLLNGGNCCEPLSLDLQSILLECVNKICAILkckkRNRERYVKEKKRKLE........................................................................................................................................................
V3ZCB7_LOTGI/5-51                .......................................................talr--------------------..------------....-----------------..---.-.-...-.------------.----..-----.--.....-.--...---..-.H...P..F.TML.VSGPTGVGKTVFVQKLLE.ANMFDPVPERIVW--..-----------....----------------------------.--------------------------------------------------------------------------------------------------------------------------------.----------------------------------.------------------------------....---------------aygewq..................................................................................................................................................
Q83894_ADEO7/2-320               .......................................................yhgq--------------------..------------....-----------------..LMT.D.L...H.NIAVNYQKTVNE.AHNL..LKD-G.CI.....P.SL...NCG..L.Q...P..F.IVT.VYGPTGSGKSQFIRNIIS.GKLIDPIPETIFFIT..PEKGTVPLEEK....IAWKAQCVEGNYDAFS----NPLTKTLN.PKFIQLAFKDAISDTNLNIDNPDNIFCRAASEGSICIIIDECMNQLGSCHSISSFFHALPSKIFNRFAKCNGYTVVVVLHNMNPRHDR-GNIKDLKIQSKCHVISPQLDSSQINRFIKNYSFGFPSAL.IPVLKDIVDHARVNSKYSWLIYNNVPITESFRWS.YYSPSDQVKPIFMNLQSLFYQACMEIRRVF....RKRTYTQNQYVKRL-n.......................................................................................................................................................
R6CBC8_9FIRM/727-822             .......................................iegavdwdctipeevdqeea--------------------..------------....-----------------..---.-.-...-.------------.YLPV..TADAS.QL.....H.AI...NMA..A.A...G..V.SFV.LHGPPGTGKSQTITALIA.NALTK--GKTVLFVA..EKRAALE----....----------------------------.--------------------------------------------------------------------------------------------------------------------------------.----------------------------------.------------------------------....---------------vvqkrlaalgiddf..........................................................................................................................................
PKG1_ADEG1/61-425                ...........................................................YEEEEYEASRDFYQRVTSWY..DGAVDL--APQL....FREQHFPSYDEFYSLGG..VNE.K.F...L.EAHEEVKAQEQM.DSRY..LQH-G.QL.....P.SI...NMG..K.Q...P..I.IGV.IYGPTGSGKSHLLRALIS.CNMLDPIPETVIFIT..PEKNMIPPIEQ....TSWNLQLVEANFDCREDGTIAPKTSTFR.PEFMEMTYEEATAPEHLNIDHPDNIYVKVSKRGPVAIIMDECMDKLCSGSSVSVLFHALPSKLFARSAHCTAFYIFVVLHNMAPRTAI-GNVPTLKVNAKMHILSCHIPQFQFARFLYAFAHNISKDL.VVLLKAYFSFLQQNQRFSWVMYTPDPVSESFRWC.SIDQQYSIIPLNVNIQERFLKTAKSIIKF-....SETHRKQLERNPKLT........................................................................................................................................................
#=GC seq_cons                    ..........................................................t.........................................................l.t.t.h.....p...ph.t..p..st.h..Lpc.G.pl.....s.Sl...Nhu..h.p...P..h.Isl.laGPTGoGKSQhlRsLIS.spLlcPhPETVlFIs..Pp+shls..E.......WphQh.EuNat........P.otshp.scFhphsacphh..pphslspscshaspsutpGslsIlhDECMppLhstpslS.hFpuhPSKl.s+....sua.hhVVLHNhsPpps..sNl.sLKlpuKhHllSsp....QhsRFl.sashshs.tl...lhpshhp..t.pppasalhass.P.p.uhpWs..hp.t.th.Ph.hslQphhhpsh.pIhth.....pppphh..th..+h.........................................................................................................................................................
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