GenomeNet

Database: Pfam
Entry: Alveol-reg_P311
LinkDB: Alveol-reg_P311
Original site: Alveol-reg_P311 
#=GF ID   Alveol-reg_P311
#=GF AC   PF11092.5
#=GF DE   Neuronal protein 3.1 (p311)
#=GF AU   Pollington J, Finn RD
#=GF SE   PRODOM
#=GF GA   25.00 25.00;
#=GF TC   43.50 43.40;
#=GF NC   20.50 18.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12417574
#=GF RT   P311 induces a TGF-beta1-independent, nonfibrogenic
#=GF RT   myofibroblast phenotype. 
#=GF RA   Pan D, Zhe X, Jakkaraju S, Taylor GA, Schuger L; 
#=GF RL   J Clin Invest. 2002;110:1349-1358.
#=GF RN   [2]
#=GF RM   16484684
#=GF RT   Identification of P311 as a potential gene regulating alveolar
#=GF RT   generation. 
#=GF RA   Zhao L, Leung JK, Yamamoto H, Goswami S, Kheradmand F, Vu TH; 
#=GF RL   Am J Respir Cell Mol Biol. 2006;35:48-54.
#=GF DR   INTERPRO; IPR024417;
#=GF CC   P311 has several PEST-like motifs and is found in neuron and
#=GF CC   muscle cells. P311 could have some function in myo-fibroblast
#=GF CC   transformation and prevention of fibrosis [1]. It has also been
#=GF CC   identified as a potential regulator of alveolar generation [2].
#=GF SQ   37
#=GS M3WZB8_FELCA/2-68      AC M3WZB8.1
#=GS F1RLG1_PIG/1-69        AC F1RLG1.1
#=GS R4GK57_CHICK/2-68      AC R4GK57.1
#=GS G3SMC9_LOXAF/1-67      AC G3SMC9.1
#=GS J9P5T4_CANFA/1-67      AC J9P5T4.1
#=GS L5MFN5_MYODS/10-76     AC L5MFN5.1
#=GS G1T1A1_RABIT/7-73      AC G1T1A1.1
#=GS W5Q3T0_SHEEP/1-67      AC W5Q3T0.1
#=GS D6R982_HUMAN/2-32      AC D6R982.1
#=GS D6RIC9_HUMAN/2-65      AC D6RIC9.1
#=GS NREP_PONAB/2-68        AC Q5NVD3.1
#=GS A2VDV5_BOVIN/2-68      AC A2VDV5.1
#=GS F6QWF7_CALJA/2-68      AC F6QWF7.1
#=GS G3UR20_MELGA/1-42      AC G3UR20.1
#=GS G5C630_HETGA/1-66      AC G5C630.1
#=GS F7H2A9_MACMU/1-67      AC F7H2A9.1
#=GS G1P728_MYOLU/2-68      AC G1P728.1
#=GS L5KLW8_PTEAL/1-48      AC L5KLW8.1
#=GS D6REJ5_HUMAN/2-32      AC D6REJ5.1
#=GS D6R9Y7_HUMAN/2-33      AC D6R9Y7.1
#=GS A0A096MV06_PAPAN/2-68  AC A0A096MV06.1
#=GS A0A0D9RR22_CHLSB/2-68  AC A0A0D9RR22.1
#=GS H0YRW9_TAEGU/1-49      AC H0YRW9.1
#=GS NREP_RAT/2-68          AC Q80Z34.1
#=GS U3J2A7_ANAPL/1-67      AC U3J2A7.1
#=GS NREP_MOUSE/2-68        AC Q07475.1
#=GS H2QRB3_PANTR/46-112    AC H2QRB3.1
#=GS G3QMC4_GORGO/46-112    AC G3QMC4.1
#=GS F6VKM3_HORSE/2-68      AC F6VKM3.1
#=GS NREP_HUMAN/2-68        AC Q16612.1
#=GS F6QC63_MONDO/1-68      AC F6QC63.1
#=GS U3K7Y1_FICAL/2-67      AC U3K7Y1.1
#=GS H2PMN1_PONAB/2-68      AC H2PMN1.1
#=GS H0UZ96_CAVPO/2-68      AC H0UZ96.1
#=GS G1RL53_NOMLE/2-68      AC G1RL53.1
#=GS V8NDI2_OPHHA/47-108    AC V8NDI2.1
#=GS NREP_CHICK/2-68        AC Q90667.1
M3WZB8_FELCA/2-68                 .VYYPELSVWVSQEPFPNKEMEGRLPKGSLPVPKEVNRKKDDKIEAASLT.PLGSS..ELHSPGISYLHSF.....
F1RLG1_PIG/1-69                   .VYYPELSVWVSQEPFPNKEMEGRLPKGRLPIPKEVNRKKDGETEAASLT.PLGSNenELHSPGISYLRSF.....
R4GK57_CHICK/2-68                 .IYQPRQTIWVSQKIFPTSQGDGGFLKGCLPISKEVNRKKESEVEGACWA.PVNGD..GHHFIKINYLYTF.....
G3SMC9_LOXAF/1-67                 a-YYPDLFVWVSREPFPNEEMEGRLPKGRLPVPKEVNRKKGNETAAASLT.PVGGD..ELCPPRISYLFSF.....
J9P5T4_CANFA/1-67                 .VCYPELSVWVSQEPFPNTEMEGRLPKGRLPIPKEVNRKKDDQMKVASLT.PPGSS..ELHAAGTSYLHSF.....
L5MFN5_MYODS/10-76                .VYYPELAVWGSQEPFPNEEMEGRLPKGRLPVPKEVNRKKNDETEAASLT.PRGSN..ELHSPSISYLHSF.....
G1T1A1_RABIT/7-73                 .VDCQDVSVGVSQGPSANQGLEGRLPEGGLPVPKEVNHKKMAGTSAASPT.PPGSH..GLRAPGVSYRHSF.....
W5Q3T0_SHEEP/1-67                 .VYYPELSVWVCQEPFPDKEMEGRLPKGRLPVPKEVNRKKDGEIGAASLT.PLGSH..ALHSPGTSYLHSF.....
D6R982_HUMAN/2-32                 .VYYPELFVWVSQEPFPNKDMEGRLPK-----------------------.-----..-------------lrkkn
D6RIC9_HUMAN/2-65                 .VYYPELFVWVSQEPFPNKDMEGRLPKGRLPVPKEVNRKKNDETNAASLT.PLGSS..ELRSPRISYL---.....
NREP_PONAB/2-68                   .VYYPELSVWVSQEPFPNKDMEGRLPKGRLPVPKEVNRKKNDETNAASLT.PLGSS..ELRSPRISYLHSF.....
A2VDV5_BOVIN/2-68                 .VYYPELSVWVCQEPFPDKEMEGRLPKGRLPVPKEVNRKKDGGIGAASLT.PLGSN..ELHSPGTSYLHSF.....
F6QWF7_CALJA/2-68                 .VYYPELLVWINQEPFPNKEMEGRLPKGRLPVPKEVNRKKDDETNAASLP.PLGSN..ELRSPRISYLHFF.....
G3UR20_MELGA/1-42                 s-----------------------FLQGCLPISKEVNRKKESEVEGACWA.PVNGG..GHHFTKINYL---.....
G5C630_HETGA/1-66                 .VYYPELCVWVSQEPFPDKEMEGRLPKGSLPVPKEVNRKKEE-TDAACLT.PLGSD..KLRSPSITYLHSF.....
F7H2A9_MACMU/1-67                 .VYYPERFVWVSQEPFPNKNMEGRLPKGRLPVPKEVNRKKNDETNAASLT.PLGSS..ELRSPRISYLHFF.....
G1P728_MYOLU/2-68                 .VYYPELAVWVSQEPFPNEEMEGRLPKGRLPVPKEVNRKKNDETEAASLT.PRGSN..ELHSPSFSYLHSF.....
L5KLW8_PTEAL/1-48                 .-------------------MEGRLPKGRLPVPKEVNRKKNDDAEAASLT.PLGSN..ELHSPRISYLYSF.....
D6REJ5_HUMAN/2-32                 .VYYPELFVWVSQEPFPNKDMEGRLPKE----------------------.-----..-------------tsls.
D6R9Y7_HUMAN/2-33                 .VYYPELFVWVSQEPFPNKDMEGRLPKGRLPVP-----------------.-----..-------------.....
A0A096MV06_PAPAN/2-68             .VYYPELFVWVSQEPFPNKNMDGRLPKGRLPVPKEVNRKKNDETNAASLT.PLGSS..ELRSPRISYLHFF.....
A0A0D9RR22_CHLSB/2-68             .VYYPELFVWVSQEPFPNKNMEGRLPKGRLPVPKEVNRKKNDETNAASLT.PLGSS..ELRSPRISYLHFF.....
H0YRW9_TAEGU/1-49                 .VYQPGSMIWISQNIFPTSRGDGGFPKGNLPISKEVNRKKSEA-EGARL-.-----..-------------dp...
NREP_RAT/2-68                     .VYYPELLVWVSQEPFPYKEMEGGLTKGRLPVPKEVNRKKMDEPIAASLI.PPGNH..EPGSPAIGYLHPF.....
U3J2A7_ANAPL/1-67                 .VNQPRSTIWVSQKIFPTSRGDGGFPEGCLPISKEVNRKKKNEVEGACWA.PVNGY..GHHFTKINYLYSF.....
NREP_MOUSE/2-68                   .VYYPELLVWVSQEPFAYKEMEGGLIKGRLPVPKEVNRKKMEETGAASLT.PPGSR..EFTSPATSYLHPF.....
H2QRB3_PANTR/46-112               .VYYPELFVWVSQEPFLNKDMEGRLPKGRLPVPKEVNRKKNDETNAASLT.PLGSS..ELRSPRISYLHFF.....
G3QMC4_GORGO/46-112               .VYYPELFVWVSQEPFPNKDMEGRLPKGRLPVPKEVNRKKNDETNAASLT.PLGSS..ELRSPRISYLHFF.....
F6VKM3_HORSE/2-68                 .VYYPELSVWVSQEPFPNKEMEGRLPKGRLPVPKEVNRKKNDETEAASLT.PLGSN..ELHSPRISYLHSF.....
NREP_HUMAN/2-68                   .VYYPELFVWVSQEPFPNKDMEGRLPKGRLPVPKEVNRKKNDETNAASLT.PLGSS..ELRSPRISYLHFF.....
F6QC63_MONDO/1-68                 .VCHPKLTVWIGQDSFPTNQEDERFLKENLPVPREVNRKKQDEIAATSLIlLSGSD..GQYSTRINYLYSF.....
U3K7Y1_FICAL/2-67                 .VYQPGSMIWISQKIFPTSCGVGGFPKGNLPISKEVNRKKSEE-EGACLA.PASGY..GQHFTKINYLYSF.....
H2PMN1_PONAB/2-68                 .VYYPKLFVWVSQEPFPNKDMEGRLPKGRLPVPKEVNHKKNDETNAASLT.PLGSS..ELRSPRISYLHFF.....
H0UZ96_CAVPO/2-68                 .VYYPELFVWVSQEPFPDKEMEGRLLKGSLPVPKEVNRKKNKETDAASLT.PLGSS..DLRSPSSSYLHSF.....
G1RL53_NOMLE/2-68                 .VYYPELFVWVSQEPFPNKDMEGRLPKGRLPVPKEVNRKKNDETNAASLT.PLGSS..ELRSPRISYLHFF.....
V8NDI2_OPHHA/47-108               .VYHPRLT--VSQKHIPMSHGHGGFIKDNLPIPKEVNRKKNET--ALFLT.PVNGS..GHHFNKIYYL---sf...
NREP_CHICK/2-68                   .IYQPRQTIWVSQKVFPTSQGDGGFLKGCLPISKEVNRKKESEVEGACWA.PVNGD..GHHFTKINYLYTF.....
#=GC seq_cons                     .VYYPELhVWVSQEPFPsK-MEGRLPKGRLPVPKEVNRKKs-EspAASLT.PlGSs..-L+SPpISYL+.F.....
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