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Database: Pfam
Entry: Anthrax-tox_M
LinkDB: Anthrax-tox_M
Original site: Anthrax-tox_M 
#=GF ID   Anthrax-tox_M
#=GF AC   PF09156.7
#=GF DE   Anthrax toxin lethal factor, middle domain
#=GF AU   Sammut SJ
#=GF SE   pdb_1j7n
#=GF GA   25.00 25.00;
#=GF TC   653.60 653.60;
#=GF NC   21.10 19.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Anthrax_toxin
#=GF RN   [1]
#=GF RM   11700563
#=GF RT   Crystal structure of the anthrax lethal factor. 
#=GF RA   Pannifer AD, Wong TY, Schwarzenbacher R, Renatus M, Petosa C,
#=GF RA   Bienkowska J, Lacy DB, Collier RJ, Park S, Leppla SH, Hanna P,
#=GF RA   Liddington RC; 
#=GF RL   Nature. 2001;414:229-233.
#=GF DR   INTERPRO; IPR015239;
#=GF DR   SCOP; 1j7n; fa;
#=GF CC   Members of this family, which are predominantly found in anthrax
#=GF CC   toxin lethal factor, adopt a structure consisting of a core of
#=GF CC   antiparallel beta sheets and alpha helices. They form a long
#=GF CC   deep groove within the protein that anchors the 16-residue
#=GF CC   N-terminal tail of MAPKK-2 before cleavage. It has been noted
#=GF CC   that this domain resembles the ADP-ribosylating toxin from
#=GF CC   Bacillus cereus, but the active site has been modified to
#=GF CC   augment substrate recognition [1].
#=GF SQ   1
#=GS LEF_BACAN/297-583  AC P15917.2
#=GS LEF_BACAN/297-583  DR PDB; 1PWV B; 267-550;
#=GS LEF_BACAN/297-583  DR PDB; 4PKR A; 267-550;
#=GS LEF_BACAN/297-583  DR PDB; 1PWW A; 267-550;
#=GS LEF_BACAN/297-583  DR PDB; 1J7N A; 267-550;
#=GS LEF_BACAN/297-583  DR PDB; 1PWP B; 267-550;
#=GS LEF_BACAN/297-583  DR PDB; 1PWQ B; 267-550;
#=GS LEF_BACAN/297-583  DR PDB; 1PWP A; 267-550;
#=GS LEF_BACAN/297-583  DR PDB; 1JKY A; 267-550;
#=GS LEF_BACAN/297-583  DR PDB; 4PKQ A; 267-550;
#=GS LEF_BACAN/297-583  DR PDB; 4PKU A; 267-550;
#=GS LEF_BACAN/297-583  DR PDB; 1PWU A; 267-550;
#=GS LEF_BACAN/297-583  DR PDB; 1PWU B; 267-550;
#=GS LEF_BACAN/297-583  DR PDB; 4PKV A; 267-550;
#=GS LEF_BACAN/297-583  DR PDB; 1PWV A; 267-550;
#=GS LEF_BACAN/297-583  DR PDB; 1PWQ A; 267-550;
#=GS LEF_BACAN/297-583  DR PDB; 4DV8 A; 267-550;
#=GS LEF_BACAN/297-583  DR PDB; 4PKS A; 267-550;
#=GS LEF_BACAN/297-583  DR PDB; 1J7N B; 267-550;
#=GS LEF_BACAN/297-583  DR PDB; 4PKW A; 267-550;
#=GS LEF_BACAN/297-583  DR PDB; 1PWW B; 267-550;
#=GS LEF_BACAN/297-583  DR PDB; 4PKT A; 267-550;
#=GS LEF_BACAN/297-583  DR PDB; 1YQY A; 267-550;
LEF_BACAN/297-583             MLARYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSSDFLSTEEKEFLKKLQIDIRDSLSEEEKELLNRIQVDSSNPLSEKEKEFLKKLKLDIQPYDINQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYENMNINNLTATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSPDTRAGYLENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVV
#=GR LEF_BACAN/297-583  SS    XXXHHHHHHHHHHHTHHHHHC--HHHHHHHHHHHS-B---HHHHHHTSTHHHHHHHHHS-GGGSSSS-HHHHHHHHHHHHHHHTSSSHHHHHHHHHCTTTTTSS-THHHHHHHHHHHHHTS-B-HHHHHHHHTT-TTSSSS-HHHHHHHHHHHHHHHHHS-CBSHTTTTST-EEEEEEEGGGTHHHHHTTSB-SSSTTSB-HHHHHHHHCT-SEEEESS-EEEESS-----TTEEEEEEEE--TT-BEEEETTTEEEE-SSEEEEEEEEEEEEETTEEEEEEEEEEE
#=GC SS_cons                  XXXHHHHHHHHHHHTHHHHHC--HHHHHHHHHHHS-B---HHHHHHTSTHHHHHHHHHS-GGGSSSS-HHHHHHHHHHHHHHHTSSSHHHHHHHHHCTTTTTSS-THHHHHHHHHHHHHTS-B-HHHHHHHHTT-TTSSSS-HHHHHHHHHHHHHHHHHS-CBSHTTTTST-EEEEEEEGGGTHHHHHTTSB-SSSTTSB-HHHHHHHHCT-SEEEESS-EEEESS-----TTEEEEEEEE--TT-BEEEETTTEEEE-SSEEEEEEEEEEEEETTEEEEEEEEEEE
#=GC seq_cons                 MLARYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSSDFLSTEEKEFLKKLQIDIRDSLSEEEKELLNRIQVDSSNPLSEKEKEFLKKLKLDIQPYDINQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYENMNINNLTATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSPDTRAGYLENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVV
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