GenomeNet

Database: Pfam
Entry: Antigen_Bd37
LinkDB: Antigen_Bd37
Original site: Antigen_Bd37 
#=GF ID   Antigen_Bd37
#=GF AC   PF11641.3
#=GF DE   Glycosylphosphatidylinositol-anchored merozoite surface protein
#=GF AU   Pollington J
#=GF SE   pdb_2jo7
#=GF GA   25.00 25.00;
#=GF TC   180.60 180.40;
#=GF NC   20.70 20.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   18035372
#=GF RT   The solution structure of the adhesion protein Bd37 from Babesia
#=GF RT   divergens reveals structural homology with eukaryotic proteins
#=GF RT   involved in membrane trafficking. 
#=GF RA   Delbecq S, Auguin D, Yang YS, Lohr F, Arold S, Schetters T,
#=GF RA   Precigout E, Gorenflot A, Roumestand C; 
#=GF RL   J Mol Biol. 2008;375:409-424.
#=GF DR   INTERPRO; IPR021669;
#=GF CC   This family of proteins represents the core region of Bd37, a
#=GF CC   surface antigen of B.divergens which is GPI-anchored at the
#=GF CC   surface of the merozoite. The structure of the protein consists
#=GF CC   of mainly alpha folds and has three sub domains [1].
#=GF SQ   14
#=GS F4YYI1_9APIC/1-157    AC F4YYI1.1
#=GS E2CT68_9APIC/82-305   AC E2CT68.1
#=GS F4YYH9_9APIC/1-157    AC F4YYH9.1
#=GS Q0P7I6_BABDI/54-292   AC Q0P7I6.1
#=GS Q8T117_BABDI/82-305   AC Q8T117.1
#=GS Q8T117_BABDI/82-305   DR PDB; 2JO7 A; 69-292;
#=GS Q8IHK7_BABDI/72-294   AC Q8IHK7.1
#=GS F4YYI0_9APIC/1-157    AC F4YYI0.1
#=GS Q8IHK5_BABDI/82-305   AC Q8IHK5.1
#=GS Q8IHK6_BABDI/77-299   AC Q8IHK6.1
#=GS Q8IHK2_BABDI/72-295   AC Q8IHK2.1
#=GS E2CT67_9APIC/126-350  AC E2CT67.1
#=GS F4YYI2_9APIC/1-157    AC F4YYI2.1
#=GS Q8IHK3_BABDI/68-291   AC Q8IHK3.1
#=GS Q8IHK4_BABDI/72-295   AC Q8IHK4.1
F4YYI1_9APIC/1-157               ..VKSLE....ELRKELKDQRERVLRSIMDSDGPFGILQLIDFLRIIDSDLLLEVDQDMVKKAGEKVKKYLESIGIGGGSVEESLDLLMTKVY.KLTKGTVKSPAESTD.SESLTSLLLKFSEDIRAEQEHHGNKDESK.ELVI...TLGKRYEELSAKFLKLPTTFLT-------------------------------...---------..---------------------------.
E2CT68_9APIC/82-305              ..VKSLE....ELRKELKDQRERVLRSIMDSEGPFSILQLIDFLRIIDSDLLLEVDQDMVKKAGEKVKKYLESIGIGGDSVEESLDLLMTKVY.KLTRGTVKSPTESTD.SESLNSLLLKFSEDIRAEQEHHGNKDESR.ELVI...TMGERYEALFVKFGRLSTTFLTHEEVSAYLKVPEYGAPMRATESQKVEKKIAD...KLKGSDLSQ..ELKDLIAELIDLRVKLMDLLYGPIGH-g
F4YYH9_9APIC/1-157               .k-KTLD....ELRKEMRTEREKVLSTIMDSDGPYTILQLIDYLRIVNTDLLLKVDPDMVKKAGEKVKKYLESIGITGDSVEVSLDKLMTKVY.DITRGTVTKPKDSTD.SESLTSLLLKFSEELKTEQEHHGKKEESR.KLFE...TMGEKFEKLVEKLHDVAKDFLT-------------------------------...---------..---------------------------.
Q0P7I6_BABDI/54-292              ..VKSWErspaAIIKEVKEKRERLLSRIIARNGPLTISEIVDFLRAIDGDTLVGVDQAMVERAGAKVKVYLDFIGIKGQNVEESLDTLMLMVYlHFTDAPEESKTKILNiSEELNALLKKFAAELKAKRALEDSKRGTQlDLLRkvtELRMSIIDLMEKLPARADAPFSVEDIYEFLTVPDYGVPTNSFAVKAIEKKITDylgTLETSDSATknELRSLIANVIEQREHIMDLIYGPFGNY.
Q8T117_BABDI/82-305              ..VKTLD....VLRGELRGQREAFLSEIIKSDGPFTILQLVGYLRVVDTDLLLKVDSTKVDEAGKKVKAYLEKIGIRGDSVEAALDNLMIKVY.EITKGTVESSAQGTD.SEELKTLLLKFSEDLKAEQELHSEAKGGE.ALLS...SMKTQHDELLKKFAALTPTFLTSEDISGYLTVPEYGAPMNAAKWKKVEGMIHG...KLESSEVPA..NLKALVAELIELREQMMDLLYGPIGHH.
#=GR Q8T117_BABDI/82-305   SS    ..---HH....HHHHHHHHHHHHHHHHHHH--S---TTHHHHHHHHHHHHTTT---HHHHHHHHHHHHHHHHHHH--S--HHHHHHHHHHHHH.HHHHT----------.-HHHHHHHHHHHHHHHHHHHHHHTSS-HH.HHHH...HHHHHHHHHHHHHHHSSS--S-HHHHHHHHH--STT--TTT-HHHHHHHHHHH...HHTSS---H..HHHHHHHHHHHHHHHHHHHHH--SS--.
Q8IHK7_BABDI/72-294              ..VKTLD....ELRGELRGQREAFLSEIIKSDGPFTILQLVGYLRVIDTDLLLKVDSVKVTEAGKKVKTYLEKIGITGDSVEAALDNLMIKIY.ELTNGTVESSPQGTD.SEELKTLLLKFREDLRAEQELHSEAKGGE.ALLS...SMKTQHDELLKKFAALNPTFLSTEDISGYLTVPEYGAPMNAAKWKKVEGKINE...KLESSEIQG..DLKALVAEFIKLREQMMDLLYGK-GE-f
F4YYI0_9APIC/1-157               .k-KTLE....QLRNEMRGQREKVLKTIIDXDGPLTILQLIDYLRIIETDLLLKVDQELVKKAGEMVKAYLATLEITGESVEDCLDKLMKKVY.ELNRGTMTGPTEKAE.SDKVTSQLLKFSADIRAEQEHHGGKQESR.ELVL...NLGTKHKELLKKLKEADPSFLT-------------------------------...---------..---------------------------.
Q8IHK5_BABDI/82-305              ..VKTLD....VLRGELRGQREAFLSEIIKSDGPFTILQLVGYLRVVDTDPLLKVDSTKVDEAGKKVKAYLEKIGIRGDSVEAALDNLMIKVY.EITKGTVESSAQGTD.SEELKTLLLKFSEDLKAEQELHSEAKGGE.ALLS...SMKTQHDELLKKFAALTPTFLTSEDISGYLTVPEYGAPMNAAKWKKVEGMIHG...KLESSEVPA..NLKALVAELIELREQMMDLLYGPIGHH.
Q8IHK6_BABDI/77-299              ..VKTLE....DIRQELKGQRETFLSEIIKSNDALTILQLVGYLRVVDTDLLLNVDSAKVDEAGKRVKAYLKSIGIMDEKVEEGLVNLMTKVV.KLTRGTVEGSTQSTD.SEELKALLLKFSEDLKAEQERHSDKEESK.DLLN...NLSVHRDEFVKKFTEANPSFLTTDDISAFLTVPNYGSTNDHSKWKTVERKIKD...KVESRDITT..ELKTLIGELIVQRENMMDLLYGK-GE-f
Q8IHK2_BABDI/72-295              ..VKTLD....ELRGELRGQREAFLSEIIKSDGPFTILQLVGYLRVIDTDLLLKVDSVKVTEAGKKVKTYLEKIGITGDSVEAALDNLMIKIY.ELTNGTVESSPQGTD.SEELKTLLLKFREDLRAEQELHSEAKGGE.ALLS...SMKTQHDELLKKFAALNPTFLSTEDISGYLTVPEYGAPMNAAKWKKVEGKINE...KLESSEIQG..DLKALVAELIKLREQMMDLLYGPIGHH.
E2CT67_9APIC/126-350             vk-KTLE....QLREELKAQRERVLVTIMGSDGPFTILQLIDFLRIVDTDLLLKVDEEKVKKAGEKIKKYLESLGIGGNSVEESLDELMKKVY.DAKGRPTGASTSSDD.SEELKTLLPQFVKDIVAEQEHHGQKEENQ.KLVL...SLGEKHKALLKQFADISPTFLTSEDVSGYLATPEYGRPMNAAKWKEVEDKISK...KLESSGLAS..EVSTLVADLVLLREKLMDLLYGPIGH-g
F4YYI2_9APIC/1-157               ..VKSLE....ELRKELKDQRERVLRSIMDSEGPFSILQLIDFLRIIDSDLLLEVDQDMVKKAGEKVKKYLESIGIGGDSVEESLDLLMTKVY.KLTRGTVKSPTESTD.SESLNSLLLKFSEDIRAEQEHHGNKDESR.ELVI...TMGERYEALFVKFGTLSTTFLT-------------------------------...---------..---------------------------.
Q8IHK3_BABDI/68-291              ..VKSLE....DLREELKGQRETFLSKLIESDGAFGFLQLIDFLRVIDTDLLLKVDGTKVEKAGVKVKAYLESIGIKGGSVEECLDNLMTKVS.AITRGTVEGSAQSTD.SEDLKTLLLKFSEDLKAEQERHGDKDESK.ELLK...NLGVQRDELVKKFTEMSPSFLTSEDISGFLTVPEYGFPMDAAKWKKVEKKISD...KLESSDITT..DLKTLLAKLIEQREKMMDLLYGPIGHE.
Q8IHK4_BABDI/72-295              ..VKTLD....ELRGELRGQREAFLSEIIKSDGPFTILQLVGYLRVIDTDLLLKVDSVKVTEAGKKVKTYLEKIGITGDSVEAALDNLMIKIY.ELTNGTVESSPQGTD.SEELKTLLLKFREDLRAEQELHSEAKGGE.ALLS...SMKTQHDELLKKFAALNPTFLSTEDISGYLTVPEYGAPMNAAKWKKVEGKINE...KLESSEIQG..DLKALVAELIKLREQMMDLLYGPIGHH.
#=GC SS_cons                     ..---HH....HHHHHHHHHHHHHHHHHHH--S---TTHHHHHHHHHHHHTTT---HHHHHHHHHHHHHHHHHHH--S--HHHHHHHHHHHHH.HHHHT----------.-HHHHHHHHHHHHHHHHHHHHHHTSS-HH.HHHH...HHHHHHHHHHHHHHHSSS--S-HHHHHHHHH--STT--TTT-HHHHHHHHHHH...HHTSS---H..HHHHHHHHHHHHHHHHHHHHH--SS--.
#=GC seq_cons                    ..VKTL-....-LRpEL+uQREphLSpIIcSDGPFTILQLlsaLRlIDTDLLLKVDpshVccAGcKVKsYLEpIGIsG-SVEtuLDpLMhKVY.clT+GTVcSsspuTD.SE-LpoLLLKFSEDL+AEQEhHupKctuc.cLlp...ohtpp+-ELlKKFsslsPTFLTsEDlSuaLsVP-YGhPhsuschKpVEthIpt...KLEoS-l.s..pL+sLlAclI..REphMDLLYG..Gc..
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