GenomeNet

Database: Pfam
Entry: Aromatic_hydrox
LinkDB: Aromatic_hydrox
Original site: Aromatic_hydrox 
#=GF ID   Aromatic_hydrox
#=GF AC   PF11723.6
#=GF DE   Homotrimeric ring hydroxylase
#=GF AU   Radauer C, Mistry J
#=GF SE   Pfam-B_24837 (release 22.0)
#=GF GA   21.80 21.80;
#=GF TC   22.00 22.30;
#=GF NC   21.20 21.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   16005887
#=GF RT   Structure of the terminal oxygenase component of angular
#=GF RT   dioxygenase, carbazole 1,9a-dioxygenase. 
#=GF RA   Nojiri H, Ashikawa Y, Noguchi H, Nam JW, Urata M, Fujimoto Z,
#=GF RA   Uchimura H, Terada T, Nakamura S, Shimizu K, Yoshida T, Habe H,
#=GF RA   Omori T; 
#=GF RL   J Mol Biol. 2005;351:355-370.
#=GF RN   [2]
#=GF RM   18922149
#=GF RT   The Bet v 1 fold: an ancient, versatile scaffold for binding of
#=GF RT   large, hydrophobic ligands. 
#=GF RA   Radauer C, Lackner P, Breiteneder H; 
#=GF RL   BMC Evol Biol. 2008;8:286.
#=GF DR   INTERPRO; IPR021028;
#=GF CC   This domain is found on aromatic hydroxylating enzymes such as
#=GF CC   2-oxo-1,2-dihydroquinoline 8-monooxygenase from Pseudomonas
#=GF CC   putida and carbazole 1,9a-dioxygenase from Janthinobacterium.
#=GF CC   These enzymes are homotrimers and are distantly related to the
#=GF CC   typical oxygenase [2].  This domain is found C terminal to the
#=GF CC   Rieske domain which binds an iron-sulphur cluster.
#=GF SQ   30
#=GS A1K6X3_AZOSB/159-411      AC A1K6X3.1
#=GS A0A0C5X9X5_NOCSI/179-416  AC A0A0C5X9X5.1
#=GS Q6NB47_RHOPA/134-383      AC Q6NB47.1
#=GS G2NU11_STRVO/151-218      AC G2NU11.1
#=GS W0AIH3_9SPHN/139-380      AC W0AIH3.1
#=GS A1U5M7_MARHV/145-400      AC A1U5M7.1
#=GS K5Z8V9_9PSED/157-409      AC K5Z8V9.1
#=GS Q0VRS8_ALCBS/139-396      AC Q0VRS8.1
#=GS D3D2B9_9ACTN/179-437      AC D3D2B9.1
#=GS D9WTJ2_9ACTN/218-285      AC D9WTJ2.1
#=GS Q0RCN4_FRAAA/149-407      AC Q0RCN4.1
#=GS A0A0M8VEE4_9ACTN/110-203  AC A0A0M8VEE4.1
#=GS Q47GC4_DECAR/158-410      AC Q47GC4.1
#=GS A1SIL1_NOCSJ/147-268      AC A1SIL1.1
#=GS E9SWS0_RHOHA/148-215      AC E9SWS0.1
#=GS D9WTJ2_9ACTN/334-458      AC D9WTJ2.1
#=GS A1U5M6_MARHV/139-396      AC A1U5M6.1
#=GS E9SWS0_RHOHA/285-391      AC E9SWS0.1
#=GS S6AKJ2_PSERE/136-377      AC S6AKJ2.1
#=GS E9T7Z3_RHOHA/138-389      AC E9T7Z3.1
#=GS K0C390_CYCSP/141-385      AC K0C390.1
#=GS D5WI30_BURSC/163-418      AC D5WI30.1
#=GS Q0VRS9_ALCBS/145-400      AC Q0VRS9.1
#=GS G2NU11_STRVO/266-391      AC G2NU11.1
#=GS C5BRU7_TERTT/143-384      AC C5BRU7.1
#=GS V9XP75_9NOCA/285-391      AC V9XP75.1
#=GS D6A8D3_9ACTN/130-368      AC D6A8D3.1
#=GS G7UUT7_PSEUP/137-376      AC G7UUT7.1
#=GS Q0A5U3_ALKEH/138-395      AC Q0A5U3.1
#=GS V9XP75_9NOCA/148-215      AC V9XP75.1
A1K6X3_AZOSB/159-411                 ......................fp---DSD....VPPLADDLPFRfpenserfphplwpaapsLLDDNAVAL.GMHRTGYGNWRIACENGFDNAH.I.LVHKDNTIVHAMDWVLPLGI....LPTSDDCIT..-.-VVEDE.KGPKGMMQWL.....fTDRW..APVLE.NK.ELGLKVEGLN--..--GRF...............YR....TSVVLPGVLMVENWPGEHIVQYEWYVPITDDLHEYWEVLVKVCPDEKARADFDYKF.ERVYKPLCLH.......GFNDCDLYAREAMQNFYADGTGWDDEQLVATDISPITWRKLASR.WNRGI-a........................................................
A0A0C5X9X5_NOCSI/179-416             ........................YVGDAQg.ddVPPVERDIPNE..................LLDNDFVMG.GRWDVREGNWRFAAENGFDEGH.AkYLHNTALWRLFKVMPAWNMT....RIVEEDGWL..I.RVQDEV.HWEAEFPGLG......TWTN..KRWWKrMP.LPDAPGKGKRVN..PVIKG...............LNipgfVSFRLPGLLRVA---YPEFIHFEWYVPVNEDQVRYVQILVRF-ETGAKASVFKAKY.LSAIRWLFHG.......QFTGQDAWMVDVMNA--------PPEKLYRPDLSLTAIRRHIEQ.VAPTVQ.........................................................
Q6NB47_RHOPA/134-383                 ........................YLGAGE....PPAFPE-I-DC..................FIAPDTHVF.AFKGLMECNWLQALEVGIDPAH.AsFLHR---FFEDEDTSQAYGKqfrgASAGSDLPM..T.KVLREY.DRP--IINVE......HTEYglRLIAL.RE.IDDERTHVRVTN.qLFPHGfvip.......msteMT....ITQWHVPVDDTHCYWYAIFTSYA--APVDKVKMRDQRLELYELPNYKSRRNKTNDY.GFDPHEQATAtytgmglDINVHDQWAVESMGAIQDR----TREHLGQSDKAIIQYRRLLR-.------qeieka...................................................
G2NU11_STRVO/151-218                 ....................yipi--ADEE....PHSIDSQLPEE..................LVSNAFVMG.GRIEPRGGNWRFACENGFDEGH.AkYLHRTALW------------....---------..-.------.----------......----..-----.--.------------..-----...............--....--------------------------------------------------------.----------.......--------------------------------------------.------rlfkpmpt.................................................
W0AIH3_9SPHN/139-380                 ........................FLGDED...aVHELKKDVPPG..................FLDEDLMVL.GKHRVVNSNWRLGAENGFDALH.I.FIHKDTTLRHYRTFNFPIGH....TP---LPGA..V.QVVEDA.DGPKGVMDDF......AQH-..TPVWD.GV.IDGEVVVSGPRS..AQVKGts...........asVG....TSIWLPGVLKVESFPTGGLTQFEWYVPLDGERHLYVQTIGKACTTHDERIDFANAF.EAIWKPHGLD.......GFNGDDIWAREVTEPFYADDFGWVDEMLCEPDETILQWRRLASR.HGRGVQ.........................................................
A1U5M7_MARHV/145-400                 ........................FVGDADy.apIPPLESDLPPQeskdy.......ahyspnLTDDDAIVL.GIRRKGESNWRLAVENGFDPGH.V.LIHWKSPLVYAHDMAVPLGF....KPTSDRAVK..-.-AFEDP.DGPKGMMNMYppdadgHSHY..EPIFE.NT.MLDVRTVGGT--..-PALG...............LR....TSMWLPGVLKVENFPFPGITTHEMYVPIDDKSYEYWELLVKTAPTKTERDEFTDQY.ENYLRDAVFH.......DFNDDDLWARDSMQPFYENDVGFAEEKLCAMDAVIVAWRKLVAR.HARGIQ.........................................................
K5Z8V9_9PSED/157-409                 ......................fp---DED....VPPLSHDLPFRfpensdkfphplwpaspsVMDENAQIR.GMHRTGYGNWRIACENGFDNAH.I.LVHKDNAIVHAMEWVLPLGI....LPAADDCIT..-.-VVEDE.NGPKGMMQWM.....fTDKW..EPVLE.NK.TLDLKVEGVK--..--GRF...............YR....TSVVLPGVLMVENWPEDHVVQYEWYVPITDDTHEYWEILVRVCPTEEDVKKFDYRY.KYMYEPLCLH.......GFNDCDLYAREAMQNFYADGTGWDEEQLVATDVSPITWRKMASR.WNRGI-a........................................................
Q0VRS8_ALCBS/139-396                 ........................FVGDADf.gePPPLSHDLPPQlraage......dhycahLLNPNTTVR.GIRRQGAANWRLASENGFDPGH.V.LVHQDSPWVYAQDWALPLGF....RPVTEHATT..-.-TFVEN.NAPRGILNEYvpgadgVAHY..EPVMH.NE.MLDVSAFGGQ--..NVPAG...............LR....TSMWLPGVLLVENAPYPGMSMYEMYVPIDDQTYQYWELIACETPTPEDETAFVDQY.ENYLKKAMFN.......DFNDQDLVARDAMQPFYAQDAGWSAEQLCSLDAVIIGWRKLVAG.YARGIQ.........................................................
D3D2B9_9ACTN/179-437                 ........................YIGDEE....PPPLEADVPAS..................FLAADTVMHyAEPGIIRANWRLALENSFDPGH.H.FIHNWSPYVIESGFPMTFGY...vAKKGEEAGE..T.TYVVDA.PGPKGFSRC-......TATA..ELIFS.AV.IPGKDGRPDTTYtaPAAVGksreelissflamppIE....VGIWLPSCNETVNFP-SDMITFDWLVPIDENHTRSFMFGAKSCSTEEEAEAWRGETgRTEWYVPTVE.......KFLIDDNKARESMQTFYEKENGWDRERLYRPDLEITMFRKFFSE.HARDIQ.........................................................
D9WTJ2_9ACTN/218-285                 ....................yipi--ADEE....PHSIDSQLPEE..................LVGNGFVMG.GRIEPRGGNWRFACENGFDEGH.AkYLHRTALW------------....---------..-.------.----------......----..-----.--.------------..-----...............--....--------------------------------------------------------.----------.......--------------------------------------------.------rlfkpmpt.................................................
Q0RCN4_FRAAA/149-407                 ........................YVGDAE....PPPLEADVPAS..................FLADDIVMHyAEPNVIRANWRLALENSFDPGH.H.FIHNWSQYVIESGFPMTFGYv..aKP-GEEAGE..V.KYVVDT.TGPKGFSRC-......TRTT..ELIFS.AV.IPGKDGRPDTTYtaPAAVGrshqelvdafmamppID....VGIWLPSCNETVNFP-SDMITYDWLVPIDENTTRSFMIGGRVCATEQEAADWRGEVgRVEWREPAVE.......KFLVDDNAARESMQTFYETENGWDRERLYRPDLEITMFRKFFSE.HARAIQ.........................................................
A0A0M8VEE4_9ACTN/110-203             ........................YFGDGE...hPDPAELALPDP..................LVDDEISAF.LCYAEWNVPWRFAMENLLDPMHgA.FLHRESHTMFDGGTTAKFRI....R--------..-.------.----------......----..-----.--.------------..-----...............--....--------------------------------------------------------.----------.......--------------------------------------------.------etdrgyffektdqrgvnfdwve...................................
Q47GC4_DECAR/158-410                 ......................yp---EAD....VPPLAHDLPIRfpennerfphplwpdtpsILDKNAVVH.GMHRTGFANWRIACENGFDNAH.I.LVHKDNAIVHAKDWVLPLGI....IPTSDDCIE..-.-LVEND.DGPKGMMQWM.....fTDKW..KPILE.NK.RLDMKVENIN--..--GRF...............YR....TSVFLPGVLMVENWPEEHFVQYEFYVPITDDTYEYWEVIVKVCDTDKDRKAFDYRF.EHLFKPLCLH.......GFNDCDLHAREAMQDFYGDGTGWDEEQLVSTDVSPITWRKLASR.WNRGI-a........................................................
A1SIL1_NOCSJ/147-268                 ........................WMGESD....PAPIEEDVPPQ..................FFNDEFLIQ.VSVTSWNCNWRPAFENLLDSHV.F.YVHRNSVHLMMMDAAN----....---------..-.------.----------......----..-----.--.------------..-----...............--....--------------------------------------------------------.----------.......--------------------------------------------.------lliaskmgprrprprvvngralmyppgalgfadafvgtgakhaaekatatevktwpp
E9SWS0_RHOHA/148-215                 ...................yipia-----Ee..pAPPIDEQLPRE..................LVENEGIVG.GRIQPRGGNWRFACENGFDEGH.AkYLHRTALW------------....---------..-.------.----------......----..-----.--.------------..-----...............--....--------------------------------------------------------.----------.......--------------------------------------------.------rlfkpmpt.................................................
D9WTJ2_9ACTN/334-458                 .igntgkadkinptieaqefpgfa------....-----------..................---------.----------------------.-.--------------------....---------..-.------.----------......----..-----.--.------------..-----...............--....-SLSMPGVLRI---AYPKFIHYEFYVPVDDDNHRYVGVMVNFTEGW-KTLGFYAKY.LGAVRWLFHG.......QFSGQDAWMVDV------TDA--PPEKLYRPDVSLTSWRNLSE-.------eeygkk...................................................
A1U5M6_MARHV/139-396                 ........................FVGDADf.gePPPLSHDLPPQlraage......dhycahLLNPNTTVR.GIRRQGAANWRLASENGFDPGH.V.LVHQDSPWVYAQDWALPLGF....RPVTEHATT..-.-TFVEN.NAPRGILNEYvpgadgVAHY..EPVMH.NE.MLDVSAFGGQ--..NVPAG...............LR....TSMWLPGVLLVENAPYPGMSMYEMYVPIDDQTYQYWELIACETPTPEDETAFVDQY.ENYLKKAMFN.......DFNDQDLVARDAMQPFYAQDAGWSAEQLCSLDAVIIGWRKLVAG.YARGIQ.........................................................
E9SWS0_RHOHA/285-391                 .....................gfa------....-----------..................---------.----------------------.-.--------------------....---------..-.------.----------......----..-----.--.------------..-----...............--....-SLSMPGVLRI---AYPNFIHYEFYVPVDEDNHQYVGLMVNFV-TGAAKLGFYAKY.LGAIRWLFHG.......QFSGQDEW----MVRV--TDA--PPEKLYRPDISLTAWRNLAEEeYA----ekia.....................................................
S6AKJ2_PSERE/136-377                 ........................YLGDGD....PPPLARDTPPN..................FLDDDMEIL.GKNQIIKSNWRLAVENGFDPSH.I.YIHKDSILVKDNDLALPLGF....APGGDRKQQ..T.RVVDDDvVGRKGVYDLI......GEHG..VPVFE.GT.IGGEVVREGAYG..EKIVA...............ND....ISIWLPGVLKVNPFPNPDMMQFEWYVPIDENTHYYFQTLGKPCANDEERKNYEQEF.ESKWKPMALE.......GFNNDDIWAREAMVDFYADDKGWVNEILFEVDEAIVAWRKLASE.HNQGIQ.........................................................
E9T7Z3_RHOHA/138-389                 ........................FVGDEDy.gtPPPLSSDLPARvtndpn......ntpvphLLDEGIVIR.GIHRKLVGNWRLAAENGLDPGH.L.LVHWDNQILVALDRALPLGV....NALTDSATE..-.-EIDIP.DGPKGVMNRYd....rPDLY..QPVLD.NP.KVNMKARGTV--..--PHY...............FR....TSLWVPGVLMVEHWPITDVVQYEFYVPIDDHHHEYWEVIATRATTDEDIAEFNFKY.DNFMLPLALE.......GFNNSDVFAREATEEHYTRFDGWNNEMLCDMDYSIIAWRKMAAR.YPRG--ff.......................................................
K0C390_CYCSP/141-385                 ........................FLGDIE....PTPLINDVPPG..................FLDEGRAIR.GIKREVGSNWRIAAENGFDSTH.V.FIHKDSKLIPNNETVIPLGF....ATDREEEAKgtLwEVVNNE.DGPKGVYDNI......GQHA..VPVVE.GK.VDGETVLRPVIG.gDKRIA...............NQ....ISIWMPGALKVDPFPDPSLIQFEWYVPRDENSHWYIQTLGKEVANEAEEQEFEKDF.NEKWEDWGLR.......GFNDDDIWAREAMEEFYKDDWGWIKEQLFEPDGNIVAWRQLASE.ANRGVQ.........................................................
D5WI30_BURSC/163-418                 .................eddfple-----D....VPPLSDDLPFRfpennerfphplwpdtpsILDKDAVAH.GMHRTGFGNWRIACENGFDNAH.I.LVHKDNSIIHVNDWVLPLGI....LPVTDDCIQ..-.-VVEDE.TGPKGMMQWL.....fTEKW..APVLE.NK.ELGLKIDNLK--..--GRF...............YR....TSVVLPGVLMVENWPEEHVVQYEWYVPITDDTHEYWEVLVKICPTEEDRKKYKYRF.DRVYKELCLH.......GFNDCDLYAREAMQHFYADGTGWDNEQLVSTDISPVTWRKLASR.HNRGI-a........................................................
Q0VRS9_ALCBS/145-400                 ........................FVGDADy.apIPPLESDLPPQeskdy.......ahyspnLTDDDAIVL.GIRRKGESNWRLAVENGFDPGH.V.LIHWKSPLVYAHDMAIPLGF....KPTSDGAVK..-.-AFEDP.DGPKGMMNMYppdadgHSHY..EPIFE.NT.MLNVRASGGT--..-PALG...............LR....TSMWLPGVLKVENFPFPGITAHEMYVPIDDKSYEYWELLVKTAPTKTERDEFTDQY.ENYLRDAVFH.......DFNDDDLWARDSMQPFYENDVGFAEEKLCAMDAVIVAWRKLVAR.HARGIQ.........................................................
G2NU11_STRVO/266-391                 nigntgkadsvdptieaqdfpgfa------....-----------..................---------.----------------------.-.--------------------....---------..-.------.----------......----..-----.--.------------..-----...............--....-SLSMPGVLRI---AYPKFIHYEFYVPVDEDNHRYVGVMVNFTEG-WETLRFYAKY.LGAIRWLFHG.......QFSGQDAWMVDV------TDA--PPEKLYRPDISLTAWRNLSE-.------eeygkk...................................................
C5BRU7_TERTT/143-384                 ........................FIGDMS...pTPPLSQDVPPG..................FLDEDLMVL.GKHRDVNSNWRLGAENGFDTLH.I.FIHKDTTLRHYRDFNFPIGH....TA---LPGA..I.TLVEDP.EGPKGVEDDF......SK-H..NPIWD.GL.IDGNVVIRGPRS..NNVEGts...........asVG....TSIWLPGVLKVNSFPAPGLTQFEWYVPIDESRHIYVQTIGCKVETEEDRIDFAHNF.ETTWKPHGLD.......GFNGDDIWAREVTEPFYQDDYGWVDEMLCEPDSSILAWRRLASR.ANRGIQ.........................................................
V9XP75_9NOCA/285-391                 .....................gfa------....-----------..................---------.----------------------.-.--------------------....---------..-.------.----------......----..-----.--.------------..-----...............--....-SLSMPGVLRI---AYPNFIHYEFYVPVDEDNHQYVGLMVNFV-TGAAKLGFYAKY.LGAIRWLFHG.......QFSGQDEW----MVRV--TDA--PPEKLYRPDISLTAWRNLAEEeYA----ekia.....................................................
D6A8D3_9ACTN/130-368                 ........................YIGDVEpgeePPPVERDIPTE..................LTENTLVLG.GRSEVRDGNWRFGAENGFDEGH.AkYLHNTALWRLFKVMPTWNKT....RI-VEKDGW..L.IRVQDElHYEAEFPGVG......TFTN..KRWWK.RVpLPDHPDKNGDAN..PVIAA...............MDipgfVSVRMPGLLRVA---YPKFIHYEWYVPVDADHVRYVQLMVRF-ETGATALAFKAKY.LSAFRWLFHG.......QFTRQDAW----MVNV--TDA--PPERLYRPDLSINAWRRHVEK.------lqpvvq...................................................
G7UUT7_PSEUP/137-376                 ........................YVGDRE....PTDLSEDVPPG..................FLDADRTVF.GLHREVASNWRIAAENGFDAGH.V.YIHKDSILLKGNDIALPLGF....AP-GSSAQL..T.RSEIEP.GRPKGVFDLI......GEHS..VPVFE.GT.IEGEVKIRGNMG..SKRVA...............EN....ISMWLPCVLRVEPFPNPGLTQYEWYVPIDEDNHLYFQTIGKLCPTEAETDEFKQEF.DEKWVSMALH.......GFNDDDVMARLSTQRFYQDDRGWINEILYEPDKSIIEWRRLASE.HNRGIQ.........................................................
Q0A5U3_ALKEH/138-395                 .................fvcdedw---DED....VPPLAADLPLRypennerfphpywpdtpsVLDEHSVAL.GIHRKGYANWRLAAENGFDPGH.L.LIHKDNAIVHARDWALPLGV....KPVTDQAIA..-.-LIEDD.NGPKGFLNRY.....yTDHY..EPILE.NE.KLGVKAQGTV--..--PRY...............FR....TSMYLPGVLMVENWPEDHVVQYEWYVPITDDTYEYWEVLVKHCKDEQERKDFEYRF.ENLYKPMCLH.......GFNDCDLFARDAMQNFYADGTGWNEEQLADMDASVVTWRKIASR.HNRGL-a........................................................
V9XP75_9NOCA/148-215                 ...................yipia-----Ee..pAPPIDEQLPRE..................LVENEGIVG.GRIQPRGGNWRFACENGFDEGH.AkYLHRTALW------------....---------..-.------.----------......----..-----.--.------------..-----...............--....--------------------------------------------------------.----------.......--------------------------------------------.------rlfkpmpt.................................................
#=GC seq_cons                        ..........................uDt-....sPPlppDlP.p..................hl-sshhhh.Ghhc.htuNWRhAsENGFDsuH.h.hlHpss.hhh.tshshshGh....h...pt........hh.p..tt.tth.p........htp.....lhp.t..h.s..s...........hh................p....hShhhPGVLhlt.hs.sthhpaEaYVPlD-spapYhplhsphs.sttcphtFttca.tthh+.hhht.......tFsspDhaAh-sMt.h.tssh..stEpLhpsDhslhsWR+lspc.hs.s...........................................................
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