GenomeNet

Database: Pfam
Entry: Aromatic_hydrox
LinkDB: Aromatic_hydrox
Original site: Aromatic_hydrox 
#=GF ID   Aromatic_hydrox
#=GF AC   PF11723.3
#=GF DE   Homotrimeric ring hydroxylase
#=GF AU   Radauer C, Mistry J
#=GF SE   Pfam-B_24837 (release 22.0)
#=GF GA   20.50 20.50;
#=GF TC   20.60 20.90;
#=GF NC   20.40 19.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   16005887
#=GF RT   Structure of the terminal oxygenase component of angular
#=GF RT   dioxygenase, carbazole 1,9a-dioxygenase. 
#=GF RA   Nojiri H, Ashikawa Y, Noguchi H, Nam JW, Urata M, Fujimoto Z,
#=GF RA   Uchimura H, Terada T, Nakamura S, Shimizu K, Yoshida T, Habe H,
#=GF RA   Omori T; 
#=GF RL   J Mol Biol. 2005;351:355-370.
#=GF RN   [2]
#=GF RM   18922149
#=GF RT   The Bet v 1 fold: an ancient, versatile scaffold for binding of
#=GF RT   large, hydrophobic ligands. 
#=GF RA   Radauer C, Lackner P, Breiteneder H; 
#=GF RL   BMC Evol Biol. 2008;8:286.
#=GF DR   INTERPRO; IPR021028;
#=GF CC   This domain is found on aromatic hydroxylating enzymes such as
#=GF CC   2-oxo-1,2-dihydroquinoline 8-monooxygenase from Pseudomonas
#=GF CC   putida and carbazole 1,9a-dioxygenase from Janthinobacterium.
#=GF CC   These enzymes are homotrimers and are distantly related to the
#=GF CC   typical oxygenase [2].  This domain is found C terminal to the
#=GF CC   Rieske domain which binds an iron-sulphur cluster.
#=GF SQ   55
#=GS Q84IK2_9PSED/136-268  AC Q84IK2.1
#=GS G7D687_BRAJP/49-298   AC G7D687.1
#=GS O05935_PSEPU/157-409  AC O05935.1
#=GS O05935_PSEPU/157-409  DR PDB; 1Z03 D; 157-409;
#=GS O05935_PSEPU/157-409  DR PDB; 1Z01 E; 157-409;
#=GS O05935_PSEPU/157-409  DR PDB; 1Z01 B; 157-409;
#=GS O05935_PSEPU/157-409  DR PDB; 1Z02 F; 157-409;
#=GS O05935_PSEPU/157-409  DR PDB; 1Z03 A; 157-409;
#=GS O05935_PSEPU/157-409  DR PDB; 1Z02 B; 157-409;
#=GS O05935_PSEPU/157-409  DR PDB; 1Z01 D; 157-409;
#=GS O05935_PSEPU/157-409  DR PDB; 1Z02 A; 157-409;
#=GS O05935_PSEPU/157-409  DR PDB; 1Z01 C; 157-409;
#=GS O05935_PSEPU/157-409  DR PDB; 1Z02 E; 157-409;
#=GS O05935_PSEPU/157-409  DR PDB; 1Z03 C; 157-409;
#=GS O05935_PSEPU/157-409  DR PDB; 1Z03 E; 157-409;
#=GS O05935_PSEPU/157-409  DR PDB; 1Z01 F; 157-409;
#=GS O05935_PSEPU/157-409  DR PDB; 1Z02 D; 157-409;
#=GS O05935_PSEPU/157-409  DR PDB; 1Z01 A; 157-409;
#=GS O05935_PSEPU/157-409  DR PDB; 1Z03 B; 157-409;
#=GS O05935_PSEPU/157-409  DR PDB; 1Z03 F; 157-409;
#=GS O05935_PSEPU/157-409  DR PDB; 1Z02 C; 157-409;
#=GS A1K6X3_AZOSB/159-411  AC A1K6X3.1
#=GS Q84II6_9BURK/136-377  AC Q84II6.1
#=GS Q84II6_9BURK/136-377  DR PDB; 2DE6 A; 136-377;
#=GS Q84II6_9BURK/136-377  DR PDB; 2DE7 C; 136-377;
#=GS Q84II6_9BURK/136-377  DR PDB; 2DE6 B; 136-377;
#=GS Q84II6_9BURK/136-377  DR PDB; 2DE7 A; 136-377;
#=GS Q84II6_9BURK/136-377  DR PDB; 1WW9 A; 136-377;
#=GS Q84II6_9BURK/136-377  DR PDB; 2DE5 C; 136-377;
#=GS Q84II6_9BURK/136-377  DR PDB; 2DE6 C; 136-377;
#=GS Q84II6_9BURK/136-377  DR PDB; 2DE5 B; 136-377;
#=GS Q84II6_9BURK/136-377  DR PDB; 2DE5 A; 136-377;
#=GS Q84II6_9BURK/136-377  DR PDB; 2DE7 B; 136-377;
#=GS E4WA31_RHOE1/274-390  AC E4WA31.1
#=GS G2NU11_STRVO/268-391  AC G2NU11.1
#=GS Q8RR19_9SPHN/49-288   AC Q8RR19.1
#=GS A1U5M7_MARAV/145-400  AC A1U5M7.1
#=GS H0SYI2_9BRAD/134-384  AC H0SYI2.1
#=GS D3D2B9_9ACTO/179-437  AC D3D2B9.1
#=GS O34807_PSESP/136-377  AC O34807.1
#=GS E9SWS0_COREQ/148-214  AC E9SWS0.1
#=GS Q588D3_9ACTO/45-284   AC Q588D3.1
#=GS G2NU11_STRVO/153-217  AC G2NU11.1
#=GS C4B8G7_9BACT/139-381  AC C4B8G7.1
#=GS B5WD35_9BURK/158-412  AC B5WD35.1
#=GS C4B8G1_9BACT/139-381  AC C4B8G1.1
#=GS A1U5M6_MARAV/139-396  AC A1U5M6.1
#=GS E4WA31_RHOE1/148-214  AC E4WA31.1
#=GS Q2PFA6_9SPHN/139-378  AC Q2PFA6.1
#=GS Q2PFA6_9SPHN/139-378  DR PDB; 3GKQ F; 139-378;
#=GS Q2PFA6_9SPHN/139-378  DR PDB; 3GKQ B; 139-378;
#=GS Q2PFA6_9SPHN/139-378  DR PDB; 3GKQ C; 139-378;
#=GS Q2PFA6_9SPHN/139-378  DR PDB; 3GKQ D; 139-378;
#=GS Q2PFA6_9SPHN/139-378  DR PDB; 3GKQ A; 139-378;
#=GS Q2PFA6_9SPHN/139-378  DR PDB; 3GKQ E; 139-378;
#=GS B5MF88_9SPHN/45-284   AC B5MF88.1
#=GS Q8VRI5_9SPHN/136-375  AC Q8VRI5.1
#=GS Q0VRS9_ALCBS/145-400  AC Q0VRS9.1
#=GS B2DD11_9GAMM/136-378  AC B2DD11.1
#=GS C5BRU7_TERTT/143-384  AC C5BRU7.1
#=GS B5TB86_9SPHN/137-376  AC B5TB86.1
#=GS D6A8D3_9ACTO/130-368  AC D6A8D3.1
#=GS H1QRA3_9ACTO/126-214  AC H1QRA3.1
#=GS C1PHW7_9GAMM/138-380  AC C1PHW7.1
#=GS B7XGE8_PSEPU/136-377  AC B7XGE8.1
#=GS E9SWS0_COREQ/274-390  AC E9SWS0.1
#=GS Q8G8B6_PSERE/136-377  AC Q8G8B6.1
#=GS Q0VRS8_ALCBS/139-396  AC Q0VRS8.1
#=GS Q0RCN4_FRAAA/149-407  AC Q0RCN4.1
#=GS D5IGG0_9SPHN/136-375  AC D5IGG0.1
#=GS Q47GC4_DECAR/158-410  AC Q47GC4.1
#=GS Q2EZ55_9ENTR/136-375  AC Q2EZ55.1
#=GS D9WTJ2_9ACTO/220-284  AC D9WTJ2.1
#=GS Q2HWI0_9ACTO/142-381  AC Q2HWI0.1
#=GS Q2HWI0_9ACTO/142-381  DR PDB; 3GCF L; 142-381;
#=GS Q2HWI0_9ACTO/142-381  DR PDB; 3GCF C; 142-381;
#=GS Q2HWI0_9ACTO/142-381  DR PDB; 3GCF H; 142-381;
#=GS Q2HWI0_9ACTO/142-381  DR PDB; 3GCF I; 142-381;
#=GS Q2HWI0_9ACTO/142-381  DR PDB; 3GCF F; 142-381;
#=GS Q2HWI0_9ACTO/142-381  DR PDB; 3GCF O; 142-381;
#=GS Q2HWI0_9ACTO/142-381  DR PDB; 3GCF N; 142-381;
#=GS Q2HWI0_9ACTO/142-381  DR PDB; 3GCF E; 142-381;
#=GS Q2HWI0_9ACTO/142-381  DR PDB; 3GCF M; 142-381;
#=GS Q2HWI0_9ACTO/142-381  DR PDB; 3GCF G; 142-381;
#=GS Q2HWI0_9ACTO/142-381  DR PDB; 3GCF D; 142-381;
#=GS Q2HWI0_9ACTO/142-381  DR PDB; 3GCF A; 142-381;
#=GS Q2HWI0_9ACTO/142-381  DR PDB; 3GCF J; 142-381;
#=GS Q2HWI0_9ACTO/142-381  DR PDB; 3GCF K; 142-381;
#=GS Q2HWI0_9ACTO/142-381  DR PDB; 3GCF B; 142-381;
#=GS Q4TTW3_9PSED/136-377  AC Q4TTW3.1
#=GS D5WI30_BURSC/168-418  AC D5WI30.1
#=GS H7CHZ4_9CAUL/138-380  AC H7CHZ4.1
#=GS E5RY14_9BACT/139-381  AC E5RY14.1
#=GS Q84IG9_9SPHN/136-375  AC Q84IG9.1
#=GS E4WBC3_RHOE1/138-389  AC E4WBC3.1
#=GS C3UVB6_9BURK/137-377  AC C3UVB6.1
#=GS C4B8F4_9BACT/139-381  AC C4B8F4.1
#=GS E9T7Z3_COREQ/138-389  AC E9T7Z3.1
#=GS G0EWC6_CUPNN/159-411  AC G0EWC6.1
#=GS A1SIL1_NOCSJ/147-232  AC A1SIL1.1
#=GS G7UUT7_PSEUP/137-376  AC G7UUT7.1
#=GS D9WTJ2_9ACTO/335-458  AC D9WTJ2.1
#=GS Q0A5U3_ALHEH/138-395  AC Q0A5U3.1
#=GS O88158_PSEST/136-377  AC O88158.1
Q84IK2_9PSED/136-268             ......................YLGDGD....PPPLARDTPPN..................FLDDDMEIL.GKNQIIKSNWRLAVENGFDPSH.I.YIHKDSILVKDNDLALPLG..F..AP.gGDRKQ.QTRVVDDD.vVGRKGVYDLI......GEHGVP.VFEGTIGGEVVREGAYG...EKIVA...............ND....ISIWLPG------------------.-------------------------------....---...----...-----------------------------------------------------.......................
G7D687_BRAJP/49-298              ....................yl--GEGE....PPAFPEI--DC..................FAAPQQYTF.AFKGLIECNWLQALEVGIDPAH.AsFLHR---FFEDEDTSVAYGkqF..RGasADSEMpMTKVLREY..DRP--IINVEn....tEYGLRL.IALREIDEQRTHVRVTNqlfPQAFVipm.........steMT....ITQWHVPVDDESCYWYAIFTSYS--.TPVDRAKMRAQRLELYELPEYRSRTNKSNDYgfdpREQ...VTETytgMGPDINVHDQWAVESMGPIQDR----TREHLGQSDKAIIQYRRLLRQ------eiekv..................
O05935_PSEPU/157-409             ....................fp---DED....VPPLAHDLPFRfperseqfphplwpsspsVLDDNAVVH.GMHRTGFGNWRIACENGFDNAH.I.LVHKDNTIVHAMDWVLPLG..L..LP..TSDDC.I-AVVEDD..DGPKGMMQWL.....fTDKWAP.VLENQELGLKVEGLK--...--GRH...............YR....TSVVLPGVLMVENWPEEHVVQYEWY.VPITDDTHEYWEILVRVCPTDEDRKKFQYRY....DHM...YKPL...CLHGFNDSDLYAREAMQNFYYDGTGWDDEQLVATDISPITWRKLASRWNRGI-a......................
#=GR O05935_PSEPU/157-409  SS    ....................-----GGG....---GGGGS---TTTTTTTS--TTS-----TTSTTEEEE.EEEEEEES-HHHHHHHTT-TTG.G.GGGTT-HHHHHTTBB--SE..E..EE..SSTTS.E-EEE--S..SS--EEEE-T.....TSTTEEE.E-EETTTTEE--S-B--...-----...............-E....EEEETTTEEEEET-SSTT-EEEEEE.EESSSSEEEEEEEEEEE--SHHHHHHHHHHH....HHT...HHHH...TTTTCTHHHHHHHHHHHHHHHTSHHHHH----GGGHHHHHHHHHHHHH-S-B--......................
A1K6X3_AZOSB/159-411             ....................fp---DSD....VPPLADDLPFRfpenserfphplwpaapsLLDDNAVAL.GMHRTGYGNWRIACENGFDNAH.I.LVHKDNTIVHAMDWVLPLG..I..LP..TSDDC.I-TVVEDE..KGPKGMMQWL.....fTDRWAP.VLENKELGLKVEGLN--...--GRF...............YR....TSVVLPGVLMVENWPGEHIVQYEWY.VPITDDLHEYWEVLVKVCPDEKARADFDYKF....ERV...YKPL...CLHGFNDCDLYAREAMQNFYADGTGWDDEQLVATDISPITWRKLASRWNRGI-a......................
Q84II6_9BURK/136-377             ......................YLGDGD....PPPLARDTPPN..................FLDDDMEIL.GKNQIIKSNWRLAVENGFDPSH.I.YIHKDSILVKDNDLALPLG..F..AP.gGDRKQ.QTRVVDDD.vVGRKGVYDLI......GEHGVP.VFEGTIGGEVVREGAYG...EKIVA...............ND....ISIWLPGVLKVNPFPNPDMMQFEWY.VPIDENTHYYFQTLGKPCANDEERKKYEQEF....ESK...WKPM...ALEGFNNDDIWAREAMVDFYADDKGWVNEILFESDEAIVAWRKLASEHNQGIQ.......................
#=GR Q84II6_9BURK/136-377  SS    ......................EESSSS....---GGGGS-TT..................TT-TTEEEE.EEEEEESS-HHHHHHHHH-GGG.G.GGGTT-HHHHHTTBEE-SE..E..E-.-S-GGG.GEEEES--.TT---EEEE-H......HHHSEE.E-EEEETTEEEEE-EE-...SBE--...............SE....EEEETTTEEEEES-SSTT-EEEEEE.EEEETTEEEEEEEEEEE-SSHHHHHHHHHHH....HHT...HHHH...TTTTTTHHHHHHHHHCHHHHHTSTHHHH----GGGHHHHHHHHHHHHH-S-B-.......................
E4WA31_RHOE1/274-390             ........vnpvieaqkfpgfa------....-----------..................---------.----------------------.-.-------------------..-..--..-----.--------..----------......------.-----------------...-----...............--....-SLSMPGVLRIA---YPNFIHYEFY.VPVDEDNHQYVGLMVNFVTGA-AKLGFYAKY....LGA...IRWL...FHGQFSGQDEWMVRVTD--------APPEKLYRPDISLTAWRNLAEE------eyaeki.................
G2NU11_STRVO/268-391             gntgkadsvdptieaqdfpgfa------....-----------..................---------.----------------------.-.-------------------..-..--..-----.--------..----------......------.-----------------...-----...............--....-SLSMPGVLRIA---YPKFIHYEFY.VPVDEDNHRYVGVMVNFTEGWE-TLRFYAKY....LGA...IRWL...FHGQFSGQDAWMVDVTD--------APPEKLYRPDISLTAWRNLSEE------eygkk..................
Q8RR19_9SPHN/49-288              ......................YVGDGE....PTPLIEDVPPG..................FLDENRAIH.GQHRLVASNWRLGAENGFDAGH.V.FIHKNSILVKGNDIILPLG..F..AP..GDPDQ.LTRSEVAA..GKPKGVYDLL......GEHSVP.VFEGMIEGKPAIHGNIG...SKRVA...............IS....ISIWLPGVLKVEPWPDPELTQFEWY.VPVDETSHLYFQTLGKVVTSKEAADSFEREF....HEK...WVGL...ALNGFNDDDILARESMEPFYADDRGWSEEILFEPDRAIIEWRGLASQHNRGIQ.......................
A1U5M7_MARAV/145-400             ......................FVGDADy.apIPPLESDLPPQeskdy.......ahyspnLTDDDAIVL.GIRRKGESNWRLAVENGFDPGH.V.LIHWKSPLVYAHDMAVPLG..F..KP.tSDRAV.K--AFEDP..DGPKGMMNMYppdadgHSHYEP.IFENTMLDVRTVGGT--...-PALG...............LR....TSMWLPGVLKVENFPFPGITTHEMY.VPIDDKSYEYWELLVKTAPTKTERDEFTDQY....ENY...LRDA...VFHDFNDDDLWARDSMQPFYENDVGFAEEKLCAMDAVIVAWRKLVARHARGIQ.......................
H0SYI2_9BRAD/134-384             ....................wl--GDGA....PPAF-PDLD-C..................FTAPDAYTF.AFKGLIECNWLQALEVGIDPAH.AsFLHR---FFEDEDTSTAYGkqF..RGasADSDLpMTKVLRDY..DRPIINVERT......EYGLRI.IALREIDSERTHVRVTNqlfPHAFVipm.........steMT....ITQWHVPVDDETCYWYAIFTSYG--.APVDRAKMRAQRLELYELPDYRSRKNKSNDYgfdpREQataTYTG...MGNDINVHDQWAVESMGRIQDR----TREHLGQSDKAIVQYRRLLREQIE---ava....................
D3D2B9_9ACTO/179-437             ......................YIGDEE....PPPLEADVPAS..................FLAADTVMHyAEPGIIRANWRLALENSFDPGH.H.FIHNWSPYVIESGFPMTFG..YvaKK..GEEAG.ETTYVVDA..PGPKGFSRC-......TATAEL.IFSAVIPGKDGRPDTTYt.aPAAVGksreelissflamppIE....VGIWLPSCNETVNFP-SDMITFDWL.VPIDENHTRSFMFGAKSCSTEEEAEAWRGET...gRTE...WYVP...TVEKFLIDDNKARESMQTFYEKENGWDRERLYRPDLEITMFRKFFSEHARDIQ.......................
O34807_PSESP/136-377             ......................YLGDGD....PPPLARDTPPN..................FLDDDMEIL.GKNQIIKSNWRLAVENGFDPSH.I.YIHKDSILVKDNDLALPLG..F..AP.gGDRKQ.QTRVVDDD.vVGRKGVYDLI......GEHGVP.VFEGTIGGEVVREGAYG...EKIVA...............ND....ISIWLPGVLKVNPFPNPDMMQFEWY.VPIDENTHYYFQTLGKPCANDEERKNYEQEF....ESK...WKPM...ALEGFNNDDIWAREAMVDFYADDKGWVNEILFEVDEAIVAWRKLASEHNQGIQ.......................
E9SWS0_COREQ/148-214             ................yipiae----EP....APPIDEQLPRE..................LVENEGIVG.GRIQPRGGNWRFACENGFDEGH.AkYLHRTALW-----------..-..--..-----.--------..----------......------.-----------------...-----...............--....-------------------------.-------------------------------....---...----...-----------------------------------------------------rlfkpmp................
Q588D3_9ACTO/45-284              ......................FIGDEE....PHALSEDLPPG..................FLDEDTHLL.GIRRTVQSNWRLGVENGFDTTH.I.FMHRNSPWVSGNRLAFPYG..F..VP..ADRDA.M--QVYDE..NWPKGVLDRL......SENYMP.VFEATLDGETVLSAELTg.eEKKVA...............AQ....VSVWLPGVLKVDPFPDPTLIQYEFY.VPISETQHEYFQVLQRKVEGPEDVKTFEVEF....EER...WRDD...ALHGFNDDDVWAREAQQEFYGERDGWSKEQLFPPDMCIVKWRTLASERGRGVR.......................
G2NU11_STRVO/153-217             .....................p-IADEE....PHSIDSQLPEE..................LVSNAFVMG.GRIEPRGGNWRFACENGFDEGH.AkYLHRTALW-----------..-..--..-----.--------..----------......------.-----------------...-----...............--....-------------------------.-------------------------------....---...----...-----------------------------------------------------rlfkpmp................
C4B8G7_9BACT/139-381             ......................FVGDEGf..dVPDLSEDVPPK..................FLDEDMAIR.GMAREINSNWRVGAENGFDSTH.I.FIHKDSILIENNDLALPLG..L..VP..TGRGA.F-KSQTEE..GGPKGVFDLF.....gPETIRP.VFHGTVEGQEVRTGTPD..gKNLLP...............HN....ISIWLPGVLRVDPWPDPKLTQFEWY.VPIDGKRHMYIQTIGCRVQNEEEEARFEKEF....EER...WRPV...ALEGFNNDDIWAREAAEDFYADDTGWLREQLFEPDGNIVEWRKMASKYNRGIQ.......................
B5WD35_9BURK/158-412             .................ddfpl----ED....VPPLAQDLPIRfpenderfphplwpsapsLLDKDIVAR.GMHRTGFANWRIACENGFDNAH.I.LVHKDNAIIHAKDWVLPLG..I..VP..ASDDC.I-APVEDE..NGPKGLVQWL.....fTEKWTP.ILKNEKVGLE---ID-N...PVARP...............YR....TSVFLPGVLMVENWPEEHVVQFEWY.VPITDDTYEYWEILARVCPTEKERKDFEYRY....EYF...FKPL...CLHGFNDCDLYAREAMHDFYADGTGWDDEQLVSTDVSPITWRKIASRWNRGI-a......................
C4B8G1_9BACT/139-381             ......................FVGDEGy..eVPDLSRDVPPK..................FLDEDMAIR.GMAREINSNWRVGAENGFDSTH.I.FIHKDSILIENNDLALPLG..L..VP..TGRGA.F-KVQKEE..DGPKGVFDLF.....ePETIRP.VFQGTVEGEEVRMGTPE..gKNMLP...............HN....ISIWLPGVLRVDPWPDPKLTQFEWY.VPIDGKRHLYLQTIGCRVNSAEEEAQFDKEF....EER...WKPV...ALEGFNDDDIWAREAAEDFYADDTGWLREQLFEPDGNIIEWRKLASKHNRGIQ.......................
A1U5M6_MARAV/139-396             ......................FVGDADf.gePPPLSHDLPPQlraage......dhycahLLNPNTTVR.GIRRQGAANWRLASENGFDPGH.V.LVHQDSPWVYAQDWALPLG..F..RP.vTEHAT.T--TFVEN..NAPRGILNEYvpgadgVAHYEP.VMHNEMLDVSAFGGQ--...NVPAG...............LR....TSMWLPGVLLVENAPYPGMSMYEMY.VPIDDQTYQYWELIACETPTPEDETAFVDQY....ENY...LKKA...MFNDFNDQDLVARDAMQPFYAQDAGWSAEQLCSLDAVIIGWRKLVAGYARGIQ.......................
E4WA31_RHOE1/148-214             ................yipiae----EP....APPIDEQLPRE..................LVENEGIVG.GRIQPRGGNWRFACENGFDEGH.AkYLHRTALW-----------..-..--..-----.--------..----------......------.-----------------...-----...............--....-------------------------.-------------------------------....---...----...-----------------------------------------------------rlfkpmp................
Q2PFA6_9SPHN/139-378             ......................FVGDQE....PHDLAEDVPPG..................FLDADLAVH.GQHRVVDANWRMGVENGFDAGH.V.FIHKSSILLDGNDIALPLG..F..AP..GDPEQ.LTRSVTGE..GAPKGVFDLL......GEHSVP.IFEATIEGQPAIQGHMG...SKMVA...............IS....ISVWLPGVLKVDPFPDPTLTQFEWY.VPIDEGHHLYLQMLGRRVGSEEEARSFEAEF....REK...WVEL...ALNGFNDDDILARRSMEPFYADDRGWREEVLFESDRAIIEWRRLASQYNRGIQ.......................
#=GR Q2PFA6_9SPHN/139-378  SS    ......................EESSS-....---GGGGS-TT..................TT-TTEEEE.EEEEEESS-HHHHHHHHT-TTG.G.GGGTT-THHHHTTB-B-SE..E..EE..--GGG.SEEEE--T..TS--EEEE-T......GGGEEE.ESEEEETTEEEEE-B--...SB---...............-E....EEEETTTEEEEES-SSTT-EEEEEE.EEEETTEEEEEEEEEEE-SSHHHHHHHHHHH....HHT...HHHH...TTTTTTHHHHHHHHHHHHHHHTSHHHHH----GGGHHHHHHHHHHHHH-S-B-.......................
B5MF88_9SPHN/45-284              ......................YVGDGE....PTPLIEDVPPG..................FLDENRAIH.GQRRLVASNWRLGAENGFDAGH.V.SIHKNSILVKGNDIILPLG..F..TP..GDPDQ.LTRSEVAA..GKPKGVYDLL......GEHSVP.VFEGMIEGKPAIHGNIG...SKRVA...............IS....ISIWLPGVLKVEPWPDPELTQFEWY.VPVDETSHLYFQTLGKVVTSKEAADSFEREF....HEK...WVGL...ALNGFNDDDIMARESMEPFYADDRGWSEEILFEPDRAIIEWRRLASQHNRGIQ.......................
Q8VRI5_9SPHN/136-375             ......................YVGDGE....PTPLIEDVPPG..................FLDENRAIH.GQHRLVASNWRLGAENGFDAGH.V.FIHKNSILVKGNDIILPLG..F..AP..GDPDQ.LTRSEVAA..GKPKGVYDLL......GEHSVP.VFEGMIEGKPAIHGNIG...SKRVA...............IS....ISIWLPGVLKVEPWPDPELTQFEWY.VPVDETSHLYFQTLGKVVTSKEAADSFEREF....HEK...WVGL...ALNGFNDDDIMARESMEPFYADDRGWSEEILFEPDRAIIEWRGLASQHNRGIQ.......................
Q0VRS9_ALCBS/145-400             ......................FVGDADy.apIPPLESDLPPQeskdy.......ahyspnLTDDDAIVL.GIRRKGESNWRLAVENGFDPGH.V.LIHWKSPLVYAHDMAIPLG..F..KP..TSD-G.AVKAFEDP..DGPKGMMNMYppdadgHSHYEP.IFENTMLNVRASGGT--...-PALG...............LR....TSMWLPGVLKVENFPFPGITAHEMY.VPIDDKSYEYWELLVKTAPTKTERDEFTDQY....ENY...LRDA...VFHDFNDDDLWARDSMQPFYENDVGFAEEKLCAMDAVIVAWRKLVARHARGIQ.......................
B2DD11_9GAMM/136-378             ......................YLGDGD....TPPLSRDTPPG..................FLDDGLEIL.GICRELKANWRLGVENGFDPSH.I.YIHKDAVLVQGNDLVLPLG..F..AP.gEDRSQ.QTRVVDDDseGGRKGVYDLI......GEHGMP.VMEGTVDGEVVREGNFG...NTLVA...............ND....ISIWMPGVLKVNPWPNPDMVQFEWY.VPIDENNHYYFQTLGKKCESQEEIEAFKHAF....EFK...WKKM...ALMGFNDDDIWAREAMVDFYSDDLGWVNEILFEPDEAIIAWRKLASKHNQGIQ.......................
C5BRU7_TERTT/143-384             ......................FIGDMS...pTPPLSQDVPPG..................FLDEDLMVL.GKHRDVNSNWRLGAENGFDTLH.I.FIHKDTTLRHYRDFNFPIG..H..TA..LPGAI.T--LVEDP..EGPKGVEDDF......SKH-NP.IWDGLIDGNVVIRGPRS...NNVEGts...........asVG....TSIWLPGVLKVNSFPAPGLTQFEWY.VPIDESRHIYVQTIGCKVETEEDRIDFAHNF....ETT...WKPH...GLDGFNGDDIWAREVTEPFYQDDYGWVDEMLCEPDSSILAWRRLASRANRGIQ.......................
B5TB86_9SPHN/137-376             ......................YVGDGE....PTPLIEDVPPG..................FLDENRAIH.GQHRLVASNWRLGAENGFDAGH.V.FIHKNSILVKGNDIILPLG..F..AP..GDPDQ.LTRSEVAA..GKPKGVYDLL......GEHSVP.VFEGMIEGKPAIRGNIG...SKRVA...............IS....ISIWLPGVLKVEPWPDPELTQFEWY.VPVDETSHLYFQTLGKVVTSKEAADSFERGF....HEK...WVGL...ALNGFNDDDIMARESMEPFYADDRGWSEEILFEPDRAIIEWRGLASQHNRGIQ.......................
D6A8D3_9ACTO/130-368             ......................YIGDVEpgeePPPVERDIPTE..................LTENTLVLG.GRSEVRDGNWRFGAENGFDEGH.AkYLHNTALWRLFKVMPTWNK..T..RI..VEKDG.WLIRVQDE..LHYEAEFPGV.....gTFTNKRwWKRVPLPDHPDKNGDAN...PVIAA...............MDipgfVSVRMPGLLRVA---YPKFIHYEWY.VPVDADHVRYVQLMVRF-ETGATALAFKAKY....LSA...FRWL...FHGQFTRQDAWMVNVTD--------APPERLYRPDLSINAWRRHVEK------lqpvvq.................
H1QRA3_9ACTO/126-214             ......................YFGDEE...hPEPVELTLPEP..................LADDEISAF.LCYAEWDVPWRFAMENLLDPMHgA.FLHSESHTMFAGDTTA---..-..--..-----.--------..----------......------.-----------------...-----...............--....-------------------------.-------------------------------....---...----...-----------------------------------------------------kfriretgrgyffektdqrgvn.
C1PHW7_9GAMM/138-380             ......................FIGDEEt..vPPPLEEDVPPG..................FLSEGHVLR.GRRQDVNANWRIGAENGFDSTH.I.FIHKDSILVEDADLALPLG..L..VP..LHNGA.F-ETTEED..GGPKGVHDIF.....sPEAINP.VFEGKIDGETVRMGRPE..gKNMLP...............QT....ISIWMPCALRVQPWPAPDITQYEFY.VPIDGERHIYFQFLGKTVGSVEEEAAFDKEF....KER...WVEK...ALIGFNKDDIWAREANQEFYADDTGWLRESLFEADGNIVRWRKLADEHNRGIQ.......................
B7XGE8_PSEPU/136-377             ......................YLGDGD....PPPLARDTPPN..................FLDDDMEIL.GKNQIIKSNWRLAVENGFDPSH.I.YIHKDSILVKDNDLALPLG..F..AP.gGDRKQ.QTRVVDDD.vVGRKGVYDLI......GEHGVP.VFEGTIGGEVVREGAYG...EKIVA...............ND....ISIWLPGVLKVNPFPNPDMMQFEWY.VPIDENTHYYFQTLGKPCANDEERKNYEQEF....ESK...WKPM...ALEGFNNDDIWAREAMVDFYADDKGWVNEILFEVDEAIVAWRKLASEHNQGIQ.......................
E9SWS0_COREQ/274-390             ........vnpvieaqkfpgfa------....-----------..................---------.----------------------.-.-------------------..-..--..-----.--------..----------......------.-----------------...-----...............--....-SLSMPGVLRIA---YPNFIHYEFY.VPVDEDNHQYVGLMVNFVTGA-AKLGFYAKY....LGA...IRWL...FHGQFSGQDEWMVRVTD--------APPEKLYRPDISLTAWRNLAEE------eyaeki.................
Q8G8B6_PSERE/136-377             ......................YLGDGD....PPPLARDTPPN..................FLDDDMEIL.GKNQIIKSNWRLAVENGFDPSH.I.YIHKDSILVKDNDLALPLG..F..AP.gGDRKQ.QTRVVDDD.vVGRKGVYDLI......GEHGVP.VFEGTIGGEVVREGAYG...EKIVA...............ND....ISIWLPGVLKVNPFPNPDMMQFEWY.VPIDENTHYYFQTLGKPCANDEERKNYEQEF....ESK...WKPM...ALEGFNNDDIWAREAMVDFYADDKGWVNEILFEVDEAIVAWRKLASEHNQGIQ.......................
Q0VRS8_ALCBS/139-396             ......................FVGDADf.gePPPLSHDLPPQlraage......dhycahLLNPNTTVR.GIRRQGAANWRLASENGFDPGH.V.LVHQDSPWVYAQDWALPLG..F..RP.vTEHAT.T--TFVEN..NAPRGILNEYvpgadgVAHYEP.VMHNEMLDVSAFGGQ--...NVPAG...............LR....TSMWLPGVLLVENAPYPGMSMYEMY.VPIDDQTYQYWELIACETPTPEDETAFVDQY....ENY...LKKA...MFNDFNDQDLVARDAMQPFYAQDAGWSAEQLCSLDAVIIGWRKLVAGYARGIQ.......................
Q0RCN4_FRAAA/149-407             ......................YVGDAE....PPPLEADVPAS..................FLADDIVMHyAEPNVIRANWRLALENSFDPGH.H.FIHNWSQYVIESGFPMTFG..YvaKP..GEEAG.EVKYVVDT..TGPKGFSRC-......TRTTEL.IFSAVIPGKDGRPDTTYt.aPAAVGrshqelvdafmamppID....VGIWLPSCNETVNFP-SDMITYDWL.VPIDENTTRSFMIGGRVCATEQEAADWRGEV...gRVE...WREP...AVEKFLVDDNAARESMQTFYETENGWDRERLYRPDLEITMFRKFFSEHARAIQ.......................
D5IGG0_9SPHN/136-375             ......................YVGDGE....PTPLIEDVPPG..................FLDENRAIH.GQHRLVASNWRLGAENGFDAGH.V.LIHKNSILVKGNDIILPLG..F..AP..GDPDQ.LTRSEVAA..GKPKGVYDLL......GEHSVP.VFEGMIEGKPAIHGNIG...SKRVA...............IS....ISIWLPGVLKVEPWPDPELTQFEWY.VPVDETSHLYFQTLGKVVTSKEAADSFEREF....HEK...WVGL...ALNGFNDDDIMARESMEPFYTDDRGWSEEILFEPDRAIIEWRGLASQHNRGIQ.......................
Q47GC4_DECAR/158-410             ...................ype----AD....VPPLAHDLPIRfpennerfphplwpdtpsILDKNAVVH.GMHRTGFANWRIACENGFDNAH.I.LVHKDNAIVHAKDWVLPLG..I..IP..TSDDC.I-ELVEND..DGPKGMMQWM.....fTDKWKP.ILENKRLDMKVENIN--...--GRF...............YR....TSVFLPGVLMVENWPEEHFVQYEFY.VPITDDTYEYWEVIVKVCDTDKDRKAFDYRF....EHL...FKPL...CLHGFNDCDLHAREAMQDFYGDGTGWDEEQLVSTDVSPITWRKLASRWNRGI-a......................
Q2EZ55_9ENTR/136-375             ......................YVGDGE....PTPLIEDVPPG..................FLDENRAIH.GQHRLVASNWRLGAENGFDAGH.V.FIHKNSILVKGNDIILPLG..F..AP..GDPDQ.LTRSEVAA..GKPKGVYDLL......GEHSVP.VFEGMIEGKPAIHGNIG...SKRVA...............IS....ISIWLPGVLKVEPWPDPELTQFEWY.VPVDETSHLYFQTLGKVVTSKEAADSFEREF....HEK...WVGL...ALNGFNDDDIMARESMEPFYADDRGWSEEILFEPDRAIIEWRGLASQHNRGIQ.......................
D9WTJ2_9ACTO/220-284             .....................p-IADEE....PHSIDSQLPEE..................LVGNGFVMG.GRIEPRGGNWRFACENGFDEGH.AkYLHRTALW-----------..-..--..-----.--------..----------......------.-----------------...-----...............--....-------------------------.-------------------------------....---...----...-----------------------------------------------------rlfkpmp................
Q2HWI0_9ACTO/142-381             ......................FIGDEE....PHALSEDLPPG..................FLDEDTHLL.GIRRTVQSNWRLGVENGFDTTH.I.FMHRNSPWVSGNRLAFPYG..F..VP..ADRDA.M--QVYDE..NWPKGVLDRL......SENYMP.VFEATLDGETVLSAELTg.eEKKVA...............AQ....VSVWLPGVLKVDPFPDPTLIQYEFY.VPISETQHEYFQVLQRKVEGPEDVKTFEVEF....EER...WRDD...ALHGFNDDDVWAREAQQEFYGERDGWSKEQLFPPDMCIVKWRTLASERGRGVR.......................
#=GR Q2HWI0_9ACTO/142-381  SS    ......................EESSS-....---GGGGS-TT..................TT-TTEEEE.EEEEEESS-HHHHHHHHS-SSG.G.GGGTT-HHHHHTTBE--SE..E..EE..SSTTS.E--EEE-S..SSS-EEEE-H......HHHEEE.E-EEEETTEEEEE---SS.TSBE--...............SE....EEEETTTEEEEES-SSTTEEEEEEE.EEEETTEEEEEEEEEEE-SSHHHHHHHHHHH....HHT...HHHH...TTTTTTHHHHHHHHTTHHHHHHS-HHHH----GGGHHHHHHHHHHHHH-SEB-.......................
Q4TTW3_9PSED/136-377             ......................YLGDGD....PPPLARDTPPN..................FLDDDMEIL.GKNQIIKSNWRLAVENGFDPSH.I.YIHKDSILVKDNDLALPLG..F..AP.gGDRKQ.QTRVVDDD.vVGRKGVYDLI......GEHGVP.VFEGTIGGEVVREGAYG...EKIVA...............ND....ISIWLPGVLKVNPFPNPDMMQFEWY.VPIDENTHYYFQTLGKPCANDEERKNYEQEF....ESK...WKPM...ALEEFNNDDIWAREAMVDFYADDKGWVNEILFEVDEAIVAWRKLASEHNQGIQ.......................
D5WI30_BURSC/168-418             ledvpplsddlpfrfpennerf------....PHPLWPDTP-S..................ILDKDAVAH.GMHRTGFGNWRIACENGFDNAH.I.LVHKDNSIIHVNDWVLPLG..I..LP.vTDDCI.--QVVEDE..TGPKGMMQWL.....fTEKWAP.VLENKELGLKIDNL---...-KGRF...............YR....TSVVLPGVLMVENWPEEHVVQYEWY.VPITDDTHEYWEVLVKICPTEEDRKKYKYRF....DRV...YKEL...CLHGFNDCDLYAREAMQHFYADGTGWDNEQLVSTDISPVTWRKLASRHNRGI-a......................
H7CHZ4_9CAUL/138-380             ......................FIGDEDy..aPPPLAQDVPPG..................FLEEGRAIR.GRRQDVAANWRIGAENGFDSTH.I.FIHKDSILVEDADLALPLG..L..VP.lHNGAF.--ETTEDE..GGPKGVHDIF.....sPETINP.VFEGKIEGETVRMGRPE..gKNLLP...............QT....ISIWMPCSLRVQPWPAPDLTQYEFY.VPIDGERHIYFQFLGKTVANEKEEKAFEKEF....KER...WVEK...ALIGFNKDDIWAREANQEFYADDTGWLRESLFEADGNIVRWRKLADEHNRGIQ.......................
E5RY14_9BACT/139-381             ......................FVGDEDf..dVPDLSEDVPPK..................FLDEDMAIR.GMAREINSNWRVGAENGFDSTH.I.FIHKDSILIENNDLALPLG..L..VP..TGRGA.F-KSQTEE..GGPKGVFDLF.....gPETIRP.VFQGTVEGQEVRTGTPD..gKNLLP...............HN....ISIWVPGVLRVDPWPDPKLTQFEWY.VPIDGKRHMYIQTIGCRVKNEEEEAAFEKEF....EER...WKPV...ALEGFNNDDIWAREAAEDFYADDTGWLREQLFEPDGNIIEWRKMASKYNRGIQ.......................
Q84IG9_9SPHN/136-375             ......................YVGDGE....PTPLIEDVPPG..................FLDENRAIH.GQHRLVASNWRLGAENGFDAGH.V.FIHKNSILVKGNDIILPLG..F..AP..GDPDQ.LTRSEVAA..GKPKGVYDLL......GEHSVP.VFEGMIEGKPAIHGNIG...SKRVA...............IS....ISIWLPGVLKVEPWPDPELTQFEWY.VPVDETSHLYFQTLGKVVTSKEAADSFEREF....HEK...WVGL...ALNGFNDDDIMARESMEPFYADDRGWSEEILFEPDRAIIEWRGLASQHNRGIQ.......................
E4WBC3_RHOE1/138-389             ......................FVGDEDy.gtPPPLSSDLPARvtndpn......ntpvphLLDEGIVIR.GIHRKLVGNWRLAAENGLDPGH.L.LVHWDNQILVALDRALPLG..V..NA.lTDSAT.E--EIDIP..DGPKGVMNRYd....rPDLYQP.VLDNPKVNMKAR----G...TVPHY...............FR....TSLWVPGVLMVEHWPITDVVQYEFY.VPIDDHHHEYWEVIATRATTDEDIAEFNFKY....DNF...MLPL...ALEGFNNSDVFAREATEEHYTRFDGWNNEMLCDMDYSIIAWRKMAARYPRG--ff.....................
C3UVB6_9BURK/137-377             ......................YVGDRE....PTDLSEDVPPG..................FLDADRTVF.GLHREVASNWRMAAENGFDAGH.A.FLHKDSILLKGNDIALPLG..F..AP..GSSAQ.LTRSEIEP..GRPKGVFDLL......GEHSVP.VFEGTIEGEVKIRGNMG...SKRVI...............EN....VSMWLPCVLRVEPFPNPGLTQYEVVrARLTRTIHLYFQTIGKLCPTEAETDEFKQEF....DEK...WVSM...ALHGFNDDDVMARVSTQRFYQDDRGWINEILYEPDKAIIEWRRLASEHNRGIQ.......................
C4B8F4_9BACT/139-381             ......................FVGDEGy..eVPDLSRDVPPK..................FLDEDMAIR.GMAREIKSNWRVGAENGFDSTH.I.FIHKDSILIENNDLALPLG..L..VP..TGRGA.F-KVQKEE..DGPKGVFDLF.....ePETIRP.VFQGTVEGEEVRMGTPE..gKNMLP...............HN....ISIWLPGVLRVDPWPDPKLTQFEWY.VPIDGKRHLYLQTIGCRVNSAEEEAQFDKEF....EER...WKPV...ALEGFNDDDIWAREAAEDFYADDTGWLREQLFEPDGNIIEWRKLASKYNRGIQ.......................
E9T7Z3_COREQ/138-389             ......................FVGDEDy.gtPPPLSSDLPARvtndpn......ntpvphLLDEGIVIR.GIHRKLVGNWRLAAENGLDPGH.L.LVHWDNQILVALDRALPLG..V..NA.lTDSAT.E--EIDIP..DGPKGVMNRYd....rPDLYQP.VLDNPKVNMKAR----G...TVPHY...............FR....TSLWVPGVLMVEHWPITDVVQYEFY.VPIDDHHHEYWEVIATRATTDEDIAEFNFKY....DNF...MLPL...ALEGFNNSDVFAREATEEHYTRFDGWNNEMLCDMDYSIIAWRKMAARYPRG--ff.....................
G0EWC6_CUPNN/159-411             ....................yp---DED....VPPLSHDLPFRfpensekfphplwpsapsLLDENVVAH.GMHRTGYANWRIACENGFDNAH.I.LVHKDNAIIHAKDWVLPLG..I..VP..TADDC.I-AVVEDD..NGPKGLVQWL.....fTDKWKP.ILENEKVGLKVENLN--...--ARP...............YR....TSVVLPGVLMVENWPEEHVVQYEWY.VPITDDTYEYWEVLVKVCNTEQERKDYQYRF....DYL...YKPL...CLHGFNDCDLYAREAMQDFYADGTGWDNEQLMATDISPITWRKLASRWNRGI-a......................
A1SIL1_NOCSJ/147-232             ......................WMGESD....PAPIEEDVPPQ..................FFNDEFLIQ.VSVTSWNCNWRPAFENLLDSHV.F.YVHRNSVHLMMMDA-----..-..--..-----.--------..----------......------.-----------------...-----...............--....-------------------------.-------------------------------....---...----...-----------------------------------------------------anlliaskmgprrprprvvngra
G7UUT7_PSEUP/137-376             ......................YVGDRE....PTDLSEDVPPG..................FLDADRTVF.GLHREVASNWRIAAENGFDAGH.V.YIHKDSILLKGNDIALPLG..F..AP..GSSAQ.LTRSEIEP..GRPKGVFDLI......GEHSVP.VFEGTIEGEVKIRGNMG...SKRVA...............EN....ISMWLPCVLRVEPFPNPGLTQYEWY.VPIDEDNHLYFQTIGKLCPTEAETDEFKQEF....DEK...WVSM...ALHGFNDDDVMARLSTQRFYQDDRGWINEILYEPDKSIIEWRRLASEHNRGIQ.......................
D9WTJ2_9ACTO/335-458             .gntgkadkinptieaqefpgf------....-----------..................---------.----------------------.-.-------------------..-..--..-----.--------..----------......------.-----------------...-----...............--....ASLSMPGVLRIA---YPKFIHYEFY.VPVDDDNHRYVGVMVNFTEGWKT-LGFYAKY....LGA...VRWL...FHGQFSGQDAWMVDVTD--------APPEKLYRPDVSLTSWRNLSEE------eygkk..................
Q0A5U3_ALHEH/138-395             ...............fvcdedw---DED....VPPLAADLPLRypennerfphpywpdtpsVLDEHSVAL.GIHRKGYANWRLAAENGFDPGH.L.LIHKDNAIVHARDWALPLG..V..KP.vTDQAI.A--LIEDD..NGPKGFLNRY.....yTDHYEP.ILENEKLGVKAQGT---...-VPRY...............FR....TSMYLPGVLMVENWPEDHVVQYEWY.VPITDDTYEYWEVLVKHCKDEQERKDFEYRF....ENL...YKPM...CLHGFNDCDLFARDAMQNFYADGTGWNEEQLADMDASVVTWRKIASRHNRGL-a......................
O88158_PSEST/136-377             ......................YLGDGD....PPPLARDTPPN..................FLDDDMEIL.GKNQIIKSNWRLAVENGFDPSH.I.YIHKDSILVKDNDLALPLG..F..AP.gGDRKQ.QTRVVDDD.vVGRKGVYDLI......GEHGVP.VFEGTIGGEVVREGAYG...EKIVA...............ND....ISIWLPGVLKVNPFPNPDMMQFEWY.VPIDENTHYYFQTLGKRCANDEERKNYEQEF....ESK...WKPM...ALEGFNNDDIWAREAMVDFYADDKGWVNEILFEVDEAIVAWRKLASEHNQGIQ.......................
#=GC SS_cons                     ......................EESSSC....---GGGGS-TTTTTTTTTS..TTS.....TTSTTEEEE.EEEEEESS-HHHHHHHHT-TTG.G.GGGTT-HHHHHTTBEE-SE..E..EE..SSCCC.EEEEEC-S.TTSS-EEEE-C.....THHHEEE.ESEEEETTEEEEE-BESS.TSBE--...............SE....EEEETTTEEEEES-SSTTEEEEEEE.EEEETTEEEEEEEEEEE-SSHHHHHHHHHHH....HHT...HHHH...TTTTTTHHHHHHHHHHHHHHHTSHHHHH----GGGHHHHHHHHHHHHH-SEB-.......................
#=GC seq_cons                    ......................alGDt-....PPPLscDlPsp..................hLD-shslh.GhpchltuNWRlusENGFDsuH.l.alH+sShllcspDhsLPLG..h..hP..sspst...ts..-t..stPKGlhshh......s-phhP.lh-shh.G..shtss.t.....hhs...............hp....hSlWLPGVL+VpsaPtPchsQaEaY.VPID-spH.Yaphls+hssscc-tpsFctca....cpt...ahsh...sLpGFNssDlaAREuhpsFYs-spGWspE.LhcsDhuIltWR+LAScasRGI........................
//
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