GenomeNet

Database: Pfam
Entry: Aromatic_hydrox
LinkDB: Aromatic_hydrox
Original site: Aromatic_hydrox 
#=GF ID   Aromatic_hydrox
#=GF AC   PF11723.7
#=GF DE   Homotrimeric ring hydroxylase
#=GF AU   Radauer C, Mistry J
#=GF SE   Pfam-B_24837 (release 22.0)
#=GF GA   21.80 21.80;
#=GF TC   21.90 21.90;
#=GF NC   21.50 21.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   16005887
#=GF RT   Structure of the terminal oxygenase component of angular
#=GF RT   dioxygenase, carbazole 1,9a-dioxygenase. 
#=GF RA   Nojiri H, Ashikawa Y, Noguchi H, Nam JW, Urata M, Fujimoto Z,
#=GF RA   Uchimura H, Terada T, Nakamura S, Shimizu K, Yoshida T, Habe H,
#=GF RA   Omori T; 
#=GF RL   J Mol Biol. 2005;351:355-370.
#=GF RN   [2]
#=GF RM   18922149
#=GF RT   The Bet v 1 fold: an ancient, versatile scaffold for binding of
#=GF RT   large, hydrophobic ligands. 
#=GF RA   Radauer C, Lackner P, Breiteneder H; 
#=GF RL   BMC Evol Biol. 2008;8:286.
#=GF DR   INTERPRO; IPR021028;
#=GF CC   This domain is found on aromatic hydroxylating enzymes such as
#=GF CC   2-oxo-1,2-dihydroquinoline 8-monooxygenase from Pseudomonas
#=GF CC   putida and carbazole 1,9a-dioxygenase from Janthinobacterium.
#=GF CC   These enzymes are homotrimers and are distantly related to the
#=GF CC   typical oxygenase [2].  This domain is found C terminal to the
#=GF CC   Rieske domain which binds an iron-sulphur cluster.
#=GF SQ   50
#=GS A1K6X3_AZOSB/159-411      AC A1K6X3.1
#=GS A0A0C5X9X5_NOCSI/179-416  AC A0A0C5X9X5.1
#=GS Q6NB47_RHOPA/134-383      AC Q6NB47.1
#=GS G2NU11_STRVO/151-218      AC G2NU11.1
#=GS W0AIH3_9SPHN/139-380      AC W0AIH3.1
#=GS A0A127F4S8_9RHIZ/138-203  AC A0A127F4S8.1
#=GS A1U5M7_MARHV/145-400      AC A1U5M7.1
#=GS A0A0Q7TR40_9RHIZ/134-382  AC A0A0Q7TR40.1
#=GS W4LJB8_9BACT/89-266       AC W4LJB8.1
#=GS D3D2B9_9ACTN/179-437      AC D3D2B9.1
#=GS D9WTJ2_9ACTN/218-285      AC D9WTJ2.1
#=GS A0A0M8VEE4_9ACTN/110-203  AC A0A0M8VEE4.1
#=GS A0A177Y9X3_9NOCA/266-392  AC A0A177Y9X3.1
#=GS E9SWS0_RHOHA/148-215      AC E9SWS0.1
#=GS W4LXX5_9BACT/156-219      AC W4LXX5.1
#=GS W4LIZ7_9BACT/155-274      AC W4LIZ7.1
#=GS W9TC91_9PSED/157-406      AC W9TC91.1
#=GS A0A0T6UT23_9PSED/154-409  AC A0A0T6UT23.1
#=GS A1U5M6_MARHV/139-396      AC A1U5M6.1
#=GS E9SWS0_RHOHA/285-391      AC E9SWS0.1
#=GS K0C390_CYCSP/141-385      AC K0C390.1
#=GS Q0VRS9_ALCBS/145-400      AC Q0VRS9.1
#=GS W4LYP0_9BACT/119-225      AC W4LYP0.1
#=GS C5BRU7_TERTT/143-384      AC C5BRU7.1
#=GS V9XP75_9NOCA/285-391      AC V9XP75.1
#=GS A0A117V2Z5_9SPHN/156-411  AC A0A117V2Z5.1
#=GS D6A8D3_9ACTN/130-368      AC D6A8D3.1
#=GS A0A0C5JCC8_9RHOO/134-392  AC A0A0C5JCC8.1
#=GS V9XP75_9NOCA/148-215      AC V9XP75.1
#=GS A0A024JU56_9MYCO/146-385  AC A0A024JU56.1
#=GS B5WD35_9BURK/157-412      AC B5WD35.1
#=GS Q0VRS8_ALCBS/139-396      AC Q0VRS8.1
#=GS Q0RCN4_FRAAA/149-407      AC Q0RCN4.1
#=GS Q47GC4_DECAR/158-410      AC Q47GC4.1
#=GS A1SIL1_NOCSJ/147-268      AC A1SIL1.1
#=GS D9WTJ2_9ACTN/334-458      AC D9WTJ2.1
#=GS A0A177Y9X3_9NOCA/150-217  AC A0A177Y9X3.1
#=GS A0A166T8M6_9ACTN/175-433  AC A0A166T8M6.1
#=GS A0A0Q8DF45_9ACTN/114-206  AC A0A0Q8DF45.1
#=GS F3KQM1_9BURK/134-384      AC F3KQM1.1
#=GS W4LNL4_9BACT/116-176      AC W4LNL4.1
#=GS A0A0T1W6Z1_9MYCO/168-254  AC A0A0T1W6Z1.1
#=GS A0A109D4N8_9BURK/134-382  AC A0A109D4N8.1
#=GS S6AKJ2_PSERE/136-377      AC S6AKJ2.1
#=GS A0A126RIQ8_9SPHN/158-413  AC A0A126RIQ8.1
#=GS E9T7Z3_RHOHA/138-389      AC E9T7Z3.1
#=GS G2NU11_STRVO/266-391      AC G2NU11.1
#=GS A0A0C5JAR2_9RHOO/136-378  AC A0A0C5JAR2.1
#=GS G7UUT7_PSEUP/137-376      AC G7UUT7.1
#=GS Q0A5U3_ALKEH/138-395      AC Q0A5U3.1
A1K6X3_AZOSB/159-411                 ......................fp---DSD....VPPLADDLPFRfpenserfphplwpaapsLLDDNAVAL.GMHRTGYGNWRIACENGFDNAH.I.LVHKDNT..IVHAMDWVLPLG..I....LPTS...DDCI..T..-.-VVEDE..KGPKGMMQWL........fTDRW..APVLE.NK.EL..GLKVEGLN--...--GRF...............YR....TSVVLPGVLMVENW...P...GEHIVQYEWYVPITDDLHEYWEV..LVKVCPDEKARADFD...YKF.......ERVYKPL.......CLH.......GFNDCDLYAREAMQNFYADGTGWD...DEQLVATDISPITWRKLASR.WNRGI-a............................................................................................................................
A0A0C5X9X5_NOCSI/179-416             ........................YVGDAQg.ddVPPVERDIPNE..................LLDNDFVMG.GRWDVREGNWRFAAENGFDEGH.AkYLHNTAL..WRLFKVMPAWNM..T....RIVE...EDGW..L..I.RVQDEV..HWEAEFPGLG.........TWTN..KRWWKrMP.LP..DAPGKGKRVN...PVIKG...............LNipgfVSFRLPGLLRVA--...-...YPEFIHFEWYVPVNEDQVRYVQI..LVRF-ETGAKASVFK...AKY.......LSAIRWL.......FHG.......QFTGQDAWMVDVMNA--------P...PEKLYRPDLSLTAIRRHIEQ.VAPTVQ.............................................................................................................................
Q6NB47_RHOPA/134-383                 ........................YLGAGE....PPAFPE-I-DC..................FIAPDTHVF.AFKGLMECNWLQALEVGIDPAH.AsFLHR---..FFEDEDTSQAYG..KqfrgASAG...SDLP..M..T.KVLREY..DRP--IINVE.........HTEYglRLIAL.RE.ID..DERTHVRVTN..qLFPHGfvip.......msteMT....ITQWHVPVDDTHCY...W...YAIFTSYA--APVDKVKMRDQRL..ELYELPNYKSRRNKT...NDY.......GFDPHEQ.......ATAtytgmglDINVHDQWAVESMGAIQDR----T...REHLGQSDKAIIQYRRLLR-.------qeieka.......................................................................................................................
G2NU11_STRVO/151-218                 ....................yipi--ADEE....PHSIDSQLPEE..................LVSNAFVMG.GRIEPRGGNWRFACENGFDEGH.AkYLHRTAL..W-----------..-....----...----..-..-.------..----------.........----..-----.--.--..----------...-----...............--....--------------...-...-----------------------..---------------...---.......-------.......---.......------------------------...--------------------.------rlfkpmpt.....................................................................................................................
W0AIH3_9SPHN/139-380                 ........................FLGDED...aVHELKKDVPPG..................FLDEDLMVL.GKHRVVNSNWRLGAENGFDALH.I.FIHKDTT..LRHYRTFNFPIG..H....TP--...-LPG..A..V.QVVEDA..DGPKGVMDDF.........AQH-..TPVWD.GV.ID..GEVVVSGPRS...AQVKGts...........asVG....TSIWLPGVLKVESF...P...TGGLTQFEWYVPLDGERHLYVQT..IGKACTTHDERIDFA...NAF.......EAIWKPH.......GLD.......GFNGDDIWAREVTEPFYADDFGWV...DEMLCEPDETILQWRRLASR.HGRGVQ.............................................................................................................................
A0A127F4S8_9RHIZ/138-203             ........................YVGDQP....APPIEEDVPEE..................FLAEDAVVI.PMIELRKGDWRYAMENAVDEAH.ArYLHRKTP..FA----------..-....----...----..-..-.------..----------.........----..-----.--.--..----------...-----...............--....--------------...-...-----------------------..---------------...---.......-------.......---.......------------------------...--------------------.------ffrlfpa......................................................................................................................
A1U5M7_MARHV/145-400                 ........................FVGDADy.apIPPLESDLPPQeskdy.......ahyspnLTDDDAIVL.GIRRKGESNWRLAVENGFDPGH.V.LIHWKSP..LVYAHDMAVPLG..F....KPTS...DRAV..K..-.-AFEDP..DGPKGMMNMYppd...adgHSHY..EPIFE.NT.ML..DVRTVGGT--...-PALG...............LR....TSMWLPGVLKVENF...P...FPGITTHEMYVPIDDKSYEYWEL..LVKTAPTKTERDEFT...DQY.......ENYLRDA.......VFH.......DFNDDDLWARDSMQPFYENDVGFA...EEKLCAMDAVIVAWRKLVAR.HARGIQ.............................................................................................................................
A0A0Q7TR40_9RHIZ/134-382             .......................h-LGEGE....PPALPHF--DC..................FVAPDSHTF.AFKGMIDCNWLQSLEVGIDPVH.TsFLHR---..FFHDEDPNKGYGkmF....RDNT...KDADmpM..T.RIMREV..TRPRIEVDET.........DYGF..RIVTL.RQ.IS..DASTHVRVTNlvfP---Nafmi......pmsreMT....ISQWHVPIDDTKHY...W...YAIFTSFDKPVDKDTMRNQRLELyqLPDYIPNRNKSNDYGfdpHEQ.......ESETYTG.......MGA.......DINVHDQWACESMGAIQDR----T...QEHLGTSDKAIIAYRRLLR-.------qslea........................................................................................................................
W4LJB8_9BACT/89-266                  ........................WMGETE....PVPIEEDVPEE..................LFDPEYVAV.PYASIWPMNWTLTIENSGDSHN.S.YLHR---..------------..-....----...----..-..-.------..----------.........----..-----.--.--..----------...-----...............--....--------------...-...-----------------------..---------------...---.......-------.......---.......------------------------...--------------------.------frlrrlinfsafqqlpaywsgiriveetdnsigfvpavdapqqayypgveakwsrqvwwrwrkqrkpgvetmakqpyrnqyrlpsiarvntsithlhtryatpvdenhtlmwtfgvirtqtwwqk
D3D2B9_9ACTN/179-437                 ........................YIGDEE....PPPLEADVPAS..................FLAADTVMHyAEPGIIRANWRLALENSFDPGH.H.FIHNWSP..YVIESGFPMTFG..Y...vAKKG...EEAG..E..T.TYVVDA..PGPKGFSRC-.........TATA..ELIFS.AV.IP..GKDGRPDTTYt.aPAAVGksreelissflamppIE....VGIWLPSCNETVNF...P...-SDMITFDWLVPIDENHTRSFMF..GAKSCSTEEEAEAWR...GET......gRTEWYVP.......TVE.......KFLIDDNKARESMQTFYEKENGWD...RERLYRPDLEITMFRKFFSE.HARDIQ.............................................................................................................................
D9WTJ2_9ACTN/218-285                 ....................yipi--ADEE....PHSIDSQLPEE..................LVGNGFVMG.GRIEPRGGNWRFACENGFDEGH.AkYLHRTAL..W-----------..-....----...----..-..-.------..----------.........----..-----.--.--..----------...-----...............--....--------------...-...-----------------------..---------------...---.......-------.......---.......------------------------...--------------------.------rlfkpmpt.....................................................................................................................
A0A0M8VEE4_9ACTN/110-203             ........................YFGDGE...hPDPAELALPDP..................LVDDEISAF.LCYAEWNVPWRFAMENLLDPMHgA.FLHRESH..TMFDGGTTAKFR..I....R---...----..-..-.------..----------.........----..-----.--.--..----------...-----...............--....--------------...-...-----------------------..---------------...---.......-------.......---.......------------------------...--------------------.------etdrgyffektdqrgvnfdwve.......................................................................................................
A0A177Y9X3_9NOCA/266-392             .nigntgagkevnpviaaqkfpgf------....-----------..................---------.----------------------.-.-------..------------..-....----...----..-..-.------..----------.........----..-----.--.--..----------...-----...............--....ASLSMPGVLRI---...A...YPTFIHYEFYVPVDEENHRYVGL..MVNFVSGLG-KAKFY...VKY.......LGAIRWL.......FHG.......QFSGQDAWMVEV------TDA--P...PEKLYRPDVSLTSWRNLAEE.------eyaekl.......................................................................................................................
E9SWS0_RHOHA/148-215                 ...................yipia-----Ee..pAPPIDEQLPRE..................LVENEGIVG.GRIQPRGGNWRFACENGFDEGH.AkYLHRTAL..W-----------..-....----...----..-..-.------..----------.........----..-----.--.--..----------...-----...............--....--------------...-...-----------------------..---------------...---.......-------.......---.......------------------------...--------------------.------rlfkpmpt.....................................................................................................................
W4LXX5_9BACT/156-219                 ........................WIGDEA....PAPIEEDVPEE..................FFDPDAFIL.HGITYWDVNWEIGLENSMDSHV.N.YLHRNAL..VVL---------..-....----...----..-..-.------..----------.........----..-----.--.--..----------...-----...............--....--------------...-...-----------------------..---------------...---.......-------.......---.......------------------------...--------------------.------rtpys........................................................................................................................
W4LIZ7_9BACT/155-274                 ........................WMGDGP....PAPIEEDVPEE..................FFDDEALIF.ASETVWQCNWRPAIENIYDAHV.F.YVHRNSVqfWLVPRDLFLTM-..-....----...----..-..-.------..----------.........----..-----.--.--..----------...-----...............--....--------------...-...-----------------------..---------------...---.......-------.......---.......------------------------...--------------------.------srmgsrrarpsiingrgltyrleenpvrgqlgfestesqepayqdaypgld..........................................................................
W9TC91_9PSED/157-406                 ......................fp---DED....VPPLSHDLPFRfpenserfphplwpsspsVMDDNAQIR.GMHRTGYGNWRIACENGFDNAH.I.LVHKDNA..IVHAKDWVLPLG..I....LPTA...DDCI..S..-.-VVEDE..DGPKGLMQWL........fTDKW..QPILE.NG.PL..GLKVEGLN--...--GRF...............YR....TSVVLPGVLMVENW...P...EEHVVQYEWYVPITDDTHEYWEI..LVRVCPTEEDVKKFD...YRY.......KYMYEPL.......CLH.......GFNDCDLYAREAMQNFYSDGTGWD...EEQLVATDVSPITWRKM---.------rragia.......................................................................................................................
A0A0T6UT23_9PSED/154-409             .................eddfple-----D....VPPLSHDLPFRfpennekfphplwpdtpsVLDENAQIR.GIHRTGYGNWRIACENGFDNAH.I.LVHKDNA..IVHAMDWVLPLG..I....LPAS...DDCI..S..-.-VVEDE..NGPKGLMQWM........fTDKW..KPVLE.NP.KL..DLKVEGVK--...--GRF...............YR....TSVVLPGVLMVENW...P...EEHVVQYEWYVPITDDTHEYWEI..LVRICPTEEDVKKFD...YRF.......KYMYEPL.......CLH.......GFNDCDLYAREAMQNFYTDGTGWD...DEQLVATDISPITWRKVASR.WNRGI-a............................................................................................................................
A1U5M6_MARHV/139-396                 ........................FVGDADf.gePPPLSHDLPPQlraage......dhycahLLNPNTTVR.GIRRQGAANWRLASENGFDPGH.V.LVHQDSP..WVYAQDWALPLG..F....RPVT...EHAT..T..-.-TFVEN..NAPRGILNEYvpg...adgVAHY..EPVMH.NE.ML..DVSAFGGQ--...NVPAG...............LR....TSMWLPGVLLVENA...P...YPGMSMYEMYVPIDDQTYQYWEL..IACETPTPEDETAFV...DQY.......ENYLKKA.......MFN.......DFNDQDLVARDAMQPFYAQDAGWS...AEQLCSLDAVIIGWRKLVAG.YARGIQ.............................................................................................................................
E9SWS0_RHOHA/285-391                 .....................gfa------....-----------..................---------.----------------------.-.-------..------------..-....----...----..-..-.------..----------.........----..-----.--.--..----------...-----...............--....-SLSMPGVLRI---...A...YPNFIHYEFYVPVDEDNHQYVGL..MVNFV-TGAAKLGFY...AKY.......LGAIRWL.......FHG.......QFSGQDEW----MVRV--TDA--P...PEKLYRPDISLTAWRNLAEEeYA----ekia.........................................................................................................................
K0C390_CYCSP/141-385                 ........................FLGDIE....PTPLINDVPPG..................FLDEGRAIR.GIKREVGSNWRIAAENGFDSTH.V.FIHKDSK..LIPNNETVIPLG..F....ATDR...EEEA..KgtLwEVVNNE..DGPKGVYDNI.........GQHA..VPVVE.GK.VD..GETVLRPVIG..gDKRIA...............NQ....ISIWMPGALKVDPF...P...DPSLIQFEWYVPRDENSHWYIQT..LGKEVANEAEEQEFE...KDF.......NEKWEDW.......GLR.......GFNDDDIWAREAMEEFYKDDWGWI...KEQLFEPDGNIVAWRQLASE.ANRGVQ.............................................................................................................................
Q0VRS9_ALCBS/145-400                 ........................FVGDADy.apIPPLESDLPPQeskdy.......ahyspnLTDDDAIVL.GIRRKGESNWRLAVENGFDPGH.V.LIHWKSP..LVYAHDMAIPLG..F....KPTS...DGAV..K..-.-AFEDP..DGPKGMMNMYppd...adgHSHY..EPIFE.NT.ML..NVRASGGT--...-PALG...............LR....TSMWLPGVLKVENF...P...FPGITAHEMYVPIDDKSYEYWEL..LVKTAPTKTERDEFT...DQY.......ENYLRDA.......VFH.......DFNDDDLWARDSMQPFYENDVGFA...EEKLCAMDAVIVAWRKLVAR.HARGIQ.............................................................................................................................
W4LYP0_9BACT/119-225                 ........................WMGDGP....PAPIEEDVPEE..................FFDDEALIF.ASETVWQCNWRPAIENIYDAHV.F.YVHRNSVqfWLVPRDLFLTM-..-....----...----..-..-.------..----------.........----..-----.--.--..----------...-----...............--....--------------...-...-----------------------..---------------...---.......-------.......---.......------------------------...--------------------.------srmgarrarpsiihgrgltyrlednpvrgqlgfesnep.......................................................................................
C5BRU7_TERTT/143-384                 ........................FIGDMS...pTPPLSQDVPPG..................FLDEDLMVL.GKHRDVNSNWRLGAENGFDTLH.I.FIHKDTT..LRHYRDFNFPIG..H....TA--...-LPG..A..I.TLVEDP..EGPKGVEDDF.........SK-H..NPIWD.GL.ID..GNVVIRGPRS...NNVEGts...........asVG....TSIWLPGVLKVNSF...P...APGLTQFEWYVPIDESRHIYVQT..IGCKVETEEDRIDFA...HNF.......ETTWKPH.......GLD.......GFNGDDIWAREVTEPFYQDDYGWV...DEMLCEPDSSILAWRRLASR.ANRGIQ.............................................................................................................................
V9XP75_9NOCA/285-391                 .....................gfa------....-----------..................---------.----------------------.-.-------..------------..-....----...----..-..-.------..----------.........----..-----.--.--..----------...-----...............--....-SLSMPGVLRI---...A...YPNFIHYEFYVPVDEDNHQYVGL..MVNFV-TGAAKLGFY...AKY.......LGAIRWL.......FHG.......QFSGQDEW----MVRV--TDA--P...PEKLYRPDISLTAWRNLAEEeYA----ekia.........................................................................................................................
A0A117V2Z5_9SPHN/156-411             .................eddfple-----D....VPPLHHDLPVRfpennerfphplwpdtpsLLDEGAVAM.GMHRTGQSNWRIACENGFDNAH.I.LVHKDNT..IVHALDWVLPLG..I....LPAS...DDAI..T..-.-LIEDE..DGPKGQMQWL........fTDRW..KPVLE.NE.AL..GLKVENLK--...--GRF...............YR....TSVVLPGVLMVENW...P...EEHCVQYEWYVPITDDMYEYWEV..LVRVCKTDEDRKKFK...YRF.......DTVYVPL.......CLE.......GFNDCDLYAREAMEEFYADGTGWD...DEQLVETDISPVVWRKLASR.WNRGI-a............................................................................................................................
D6A8D3_9ACTN/130-368                 ........................YIGDVEpgeePPPVERDIPTE..................LTENTLVLG.GRSEVRDGNWRFGAENGFDEGH.AkYLHNTAL..WRLFKVMPTWNK..T....RI-V...EKDG..W..L.IRVQDE.lHYEAEFPGVG.........TFTN..KRWWK.RVpLP..DHPDKNGDAN...PVIAA...............MDipgfVSVRMPGLLRVA--...-...YPKFIHYEWYVPVDADHVRYVQL..MVRF-ETGATALAFK...AKY.......LSAFRWL.......FHG.......QFTRQDAW----MVNV--TDA--P...PERLYRPDLSINAWRRHVEK.------lqpvvq.......................................................................................................................
A0A0C5JCC8_9RHOO/134-392             ........................FIGDID....PPPLADDLQPG..................FLDADVHVVpFHKEEVHSNWRIAADSASEFNH.V.FMHKDDF..LLKYWKQPLPLV..E....MPKG...DNPY..E..G.YVPLEG..SGPKGFKDV-.........FREV..VPVFE.YK.IEceGEVGVVRSAF...NPQTEqgsi.......pfgqME....AVLVLPCGLSIGPWgsePgslVGEYVHYEWYVPIDETHHRYIIA..WGKKVSSEGEALKAE...HDV.......RTRWSYF.......EYE.......GFNKSDVLANEGTQRAYS-EAGYAfgeKENLSRIDGYCLMWRRMAAK.HNRGRQ.............................................................................................................................
V9XP75_9NOCA/148-215                 ...................yipia-----Ee..pAPPIDEQLPRE..................LVENEGIVG.GRIQPRGGNWRFACENGFDEGH.AkYLHRTAL..W-----------..-....----...----..-..-.------..----------.........----..-----.--.--..----------...-----...............--....--------------...-...-----------------------..---------------...---.......-------.......---.......------------------------...--------------------.------rlfkpmpt.....................................................................................................................
A0A024JU56_9MYCO/146-385             ........................FVGDQE....PPALSEDVPPG..................FLDPDTHCL.GIRRTVASNWRLGVENGFDTTH.I.FMHRDSP..LVSGNKLALPYG..F....VP-A...DRGA..M..-.-EVHAQ..GWPKGVVDNL.........AQNY..KPVFE.AQ.LH..GQPVLQCQLSg.dEKRVA...............AR....VSVWLPGVLKVDPF...P...DPTLVQYEFYVPVGATEHEYFQV..LQRKVANEADIQAFE...QEF.......DDKWRDL.......ALH.......GFNDDDVWAREAQEEFYRDKNGWA...NEHLFPPDMCITKWRQLAST.HARGL-s............................................................................................................................
B5WD35_9BURK/157-412                 .................eddfple-----D....VPPLAQDLPIRfpenderfphplwpsapsLLDKDIVAR.GMHRTGFANWRIACENGFDNAH.I.LVHKDNA..IIHAKDWVLPLG..I....VPAS...DDCI..A..-.-PVEDE..NGPKGLVQWL........fTEKW..TPILK.NE.KV..GLEID----N...PVARP...............YR....TSVFLPGVLMVENW...P...EEHVVQFEWYVPITDDTYEYWEI..LARVCPTEKERKDFE...YRY.......EYFFKPL.......CLH.......GFNDCDLYAREAMHDFYADGTGWD...DEQLVSTDVSPITWRKIASR.WNRGI-a............................................................................................................................
Q0VRS8_ALCBS/139-396                 ........................FVGDADf.gePPPLSHDLPPQlraage......dhycahLLNPNTTVR.GIRRQGAANWRLASENGFDPGH.V.LVHQDSP..WVYAQDWALPLG..F....RPVT...EHAT..T..-.-TFVEN..NAPRGILNEYvpg...adgVAHY..EPVMH.NE.ML..DVSAFGGQ--...NVPAG...............LR....TSMWLPGVLLVENA...P...YPGMSMYEMYVPIDDQTYQYWEL..IACETPTPEDETAFV...DQY.......ENYLKKA.......MFN.......DFNDQDLVARDAMQPFYAQDAGWS...AEQLCSLDAVIIGWRKLVAG.YARGIQ.............................................................................................................................
Q0RCN4_FRAAA/149-407                 ........................YVGDAE....PPPLEADVPAS..................FLADDIVMHyAEPNVIRANWRLALENSFDPGH.H.FIHNWSQ..YVIESGFPMTFG..Yv..aKP-G...EEAG..E..V.KYVVDT..TGPKGFSRC-.........TRTT..ELIFS.AV.IP..GKDGRPDTTYt.aPAAVGrshqelvdafmamppID....VGIWLPSCNETVNF...P...-SDMITYDWLVPIDENTTRSFMI..GGRVCATEQEAADWR...GEV......gRVEWREP.......AVE.......KFLVDDNAARESMQTFYETENGWD...RERLYRPDLEITMFRKFFSE.HARAIQ.............................................................................................................................
Q47GC4_DECAR/158-410                 ......................yp---EAD....VPPLAHDLPIRfpennerfphplwpdtpsILDKNAVVH.GMHRTGFANWRIACENGFDNAH.I.LVHKDNA..IVHAKDWVLPLG..I....IPTS...DDCI..E..-.-LVEND..DGPKGMMQWM........fTDKW..KPILE.NK.RL..DMKVENIN--...--GRF...............YR....TSVFLPGVLMVENW...P...EEHFVQYEFYVPITDDTYEYWEV..IVKVCDTDKDRKAFD...YRF.......EHLFKPL.......CLH.......GFNDCDLHAREAMQDFYGDGTGWD...EEQLVSTDVSPITWRKLASR.WNRGI-a............................................................................................................................
A1SIL1_NOCSJ/147-268                 ........................WMGESD....PAPIEEDVPPQ..................FFNDEFLIQ.VSVTSWNCNWRPAFENLLDSHV.F.YVHRNSV..HLMMMDAAN---..-....----...----..-..-.------..----------.........----..-----.--.--..----------...-----...............--....--------------...-...-----------------------..---------------...---.......-------.......---.......------------------------...--------------------.------lliaskmgprrprprvvngralmyppgalgfadafvgtgakhaaekatatevktwpp....................................................................
D9WTJ2_9ACTN/334-458                 .igntgkadkinptieaqefpgfa------....-----------..................---------.----------------------.-.-------..------------..-....----...----..-..-.------..----------.........----..-----.--.--..----------...-----...............--....-SLSMPGVLRI---...A...YPKFIHYEFYVPVDDDNHRYVGV..MVNFTEGW-KTLGFY...AKY.......LGAVRWL.......FHG.......QFSGQDAWMVDV------TDA--P...PEKLYRPDVSLTSWRNLSE-.------eeygkk.......................................................................................................................
A0A177Y9X3_9NOCA/150-217             ....................ylpi----ADe..pPHPIDDQLPRE..................LTENTGIIG.GRIQPRQGDWRFACENGFDEGH.AkYLHRTAL..W-----------..-....----...----..-..-.------..----------.........----..-----.--.--..----------...-----...............--....--------------...-...-----------------------..---------------...---.......-------.......---.......------------------------...--------------------.------rlfkpmpt.....................................................................................................................
A0A166T8M6_9ACTN/175-433             ........................YIGDQE....PPPLEADVPAS..................FLAPDTVMHyGEPGVVRANWRLXLENSFDPGH.H.FIHNWSP..YVIESGFPMTFG..Y...vAKKG...EEAG..E..V.TYVVDA..PGPKGFSRC-.........TATT..ELIFS.AV.IP..GKNGRPDTTYt.aPAAVGktreelveaflamppIE....VGIWLPSCNETVNF...P...-SNMITFDWLVPIDENTTRSFMF..GAKACATEEEAEAWR...GET......gRVEWYVP.......TVE.......KFLIDDNKARESMQTFYEKENGWD...RERLYRPDLEITMFRKFFSE.HARDIQ.............................................................................................................................
A0A0Q8DF45_9ACTN/114-206             ........................WMGEGK....PSPIAEDVPPE..................FFDPKSLVL.FSQQRWKANWRPALENLQDSHA.F.YVHRNSL..EVLSQD------..-....----...----..-..-.------..----------.........----..-----.--.--..----------...-----...............--....--------------...-...-----------------------..---------------...---.......-------.......---.......------------------------...--------------------.------ehglnlllhmgperpptkivngralvfentr..............................................................................................
F3KQM1_9BURK/134-384                 ........................YLGEGE....PPAFPE--FDC..................FVAPDSHTF.AFKGLWECNWLQALEVGMDPAH.AsFLHR---..FYEDEDTAESYGkqF....RGASadsDLAI..-..T.KVLREY..DRPDIHVQAApfgmrlttlRKLT..EAQTH.VR.VT..NV-VFPQAFV..iPMSTE...............MT....ISQWHVPVDDHRCY...W...YAIFTSFT--KPVDKQQMRAQRL..ETIELPDYISRKNKR...NEY.......GYSAEEQatktytgMGM.......DINVHDQWACESMGSIQDR----T...REHLGTTDKGIVAYRRLLVQ.A-----ieaaq........................................................................................................................
W4LNL4_9BACT/116-176                 ........................WMGETE....PVPIEEDVPED..................LFDPEYVTV.PYSSIWPMNWTLTIENSGDSHN.S.YLHR---..------------..-....----...----..-..-.------..----------.........----..-----.--.--..----------...-----...............--....--------------...-...-----------------------..---------------...---.......-------.......---.......------------------------...--------------------.------frlrrlln.....................................................................................................................
A0A0T1W6Z1_9MYCO/168-254             ........................FVGDGE...ePHPIDEQLPEE..................LVGNAAVIG.SRIMPREGNWRFACENGYDEGH.AkYLHRTAL..WRLFKAMP----..-....----...----..-..-.------..----------.........----..-----.--.--..----------...-----...............--....--------------...-...-----------------------..---------------...---.......-------.......---.......------------------------...--------------------.------vwnttkivkrgrwiyrvqqeq........................................................................................................
A0A109D4N8_9BURK/134-382             ........................YIGEGE....PPAFPE--FDC..................FVAPESHTF.AFKGLWECNWLQALEVGIDPAH.AsFLHR---..FFEDEDTSESYGkqF....RGAS..aDSQM..A.iT.QVLREY..DSPEIRIAQApygm.qlttLRKL..SQEQT.HV.RV..TNVVFPQAFV..iPMSSE...............MT....ISQWHVPVDDTHCY...W...YAIFTSF--TGPVDKQQMRDQRL..GTIELPAYTSRKNKG...NNYgynaeeqQTQTYTG.......MGM.......DINVHDQWACESMGPIQNR----T...REHLGTTDKGIVAYRRML--.------leaids.......................................................................................................................
S6AKJ2_PSERE/136-377                 ........................YLGDGD....PPPLARDTPPN..................FLDDDMEIL.GKNQIIKSNWRLAVENGFDPSH.I.YIHKDSI..LVKDNDLALPLG..F....APGG...DRKQ..Q..T.RVVDDD.vVGRKGVYDLI.........GEHG..VPVFE.GT.IG..GEVVREGAYG...EKIVA...............ND....ISIWLPGVLKVNPF...P...NPDMMQFEWYVPIDENTHYYFQT..LGKPCANDEERKNYE...QEF.......ESKWKPM.......ALE.......GFNNDDIWAREAMVDFYADDKGWV...NEILFEVDEAIVAWRKLASE.HNQGIQ.............................................................................................................................
A0A126RIQ8_9SPHN/158-413             .................eddfale-----D....VPPLAEDLPYRfpqnserfphplwpaapsILDEGAVTK.GMHRTGFGDWRIACENGFDNAH.I.LVHKDNS..IVHALNWTLPLG..I....LPTS...EDCI..E..-.-VVEDE..GQPKGMMQWL........fTDKW..APVLE.NE.RL..GLKIEGMN--...--GRF...............YR....TSVVLPGVLMVENW...P...EEHVVQYEWYVPITHDTHEYWEV..LVKICPAEEDRKAYD...YRY.......KTFYKPL.......ALN.......GFNDCDIYAREAMQDFYADGSGWD...DEQLVSTDVSPITWRKLASR.WNRGI-a............................................................................................................................
E9T7Z3_RHOHA/138-389                 ........................FVGDEDy.gtPPPLSSDLPARvtndpn......ntpvphLLDEGIVIR.GIHRKLVGNWRLAAENGLDPGH.L.LVHWDNQ..ILVALDRALPLG..V....NALT...DSAT..E..-.-EIDIP..DGPKGVMNRYd.......rPDLY..QPVLD.NP.KV..NMKARGTV--...--PHY...............FR....TSLWVPGVLMVEHW...P...ITDVVQYEFYVPIDDHHHEYWEV..IATRATTDEDIAEFN...FKY.......DNFMLPL.......ALE.......GFNNSDVFAREATEEHYTRFDGWN...NEMLCDMDYSIIAWRKMAAR.YPRG--ff...........................................................................................................................
G2NU11_STRVO/266-391                 nigntgkadsvdptieaqdfpgfa------....-----------..................---------.----------------------.-.-------..------------..-....----...----..-..-.------..----------.........----..-----.--.--..----------...-----...............--....-SLSMPGVLRI---...A...YPKFIHYEFYVPVDEDNHRYVGV..MVNFTEG-WETLRFY...AKY.......LGAIRWL.......FHG.......QFSGQDAWMVDV------TDA--P...PEKLYRPDISLTAWRNLSE-.------eeygkk.......................................................................................................................
A0A0C5JAR2_9RHOO/136-378             ........................FLGDID....PPPLVTDVPPT..................FLDDDMVIC.GQNKIVHSNWRLAAENGFDPAH.I.FIHKDSV..LIKGNDLALPLG..F....APKG...DAKM..R..T.RIVEDDeeQGAKGVFDLL.........AEAS..VPVFE.GK.ID..GKVVRTGNFG...HNRVA...............NN....ISIWLPGVLRVQPF...P...DPATTQFEWYVPVDENSHYYFQT..IGKRCASPAEEQVYM...EEF.......NTKWRAM.......ALD.......GFNNDDVWAREAMVGFYADDEGWL...KEILFEADSAIVDWRKLCSK.HNRGVQ.............................................................................................................................
G7UUT7_PSEUP/137-376                 ........................YVGDRE....PTDLSEDVPPG..................FLDADRTVF.GLHREVASNWRIAAENGFDAGH.V.YIHKDSI..LLKGNDIALPLG..F....AP-G...SSAQ..L..T.RSEIEP..GRPKGVFDLI.........GEHS..VPVFE.GT.IE..GEVKIRGNMG...SKRVA...............EN....ISMWLPCVLRVEPF...P...NPGLTQYEWYVPIDEDNHLYFQT..IGKLCPTEAETDEFK...QEF.......DEKWVSM.......ALH.......GFNDDDVMARLSTQRFYQDDRGWI...NEILYEPDKSIIEWRRLASE.HNRGIQ.............................................................................................................................
Q0A5U3_ALKEH/138-395                 .................fvcdedw---DED....VPPLAADLPLRypennerfphpywpdtpsVLDEHSVAL.GIHRKGYANWRLAAENGFDPGH.L.LIHKDNA..IVHARDWALPLG..V....KPVT...DQAI..A..-.-LIEDD..NGPKGFLNRY........yTDHY..EPILE.NE.KL..GVKAQGTV--...--PRY...............FR....TSMYLPGVLMVENW...P...EDHVVQYEWYVPITDDTYEYWEV..LVKHCKDEQERKDFE...YRF.......ENLYKPM.......CLH.......GFNDCDLFARDAMQNFYADGTGWN...EEQLADMDASVVTWRKIASR.HNRGL-a............................................................................................................................
#=GC seq_cons                        ........................ahG-t-....sPPlpcDlP.p..................hl-schhhh.uhpphhtuNWRhAhENGaDsuH.h.alH+ss...hhh..shshshh..h....h................................t..............................s.................................t....hShhhPsl..h............thhpa-hhVPlscpph.hhth..hsp.h.s.tpt.ta.....pa..........hh.h.......hht.......tFsspD.hhh-sh..h..p....s....E.Lht.Dhs.htaRphht.....................................................................................................................................
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