GenomeNet

Database: Pfam
Entry: Arylesterase
LinkDB: Arylesterase
Original site: Arylesterase 
#=GF ID   Arylesterase
#=GF AC   PF01731.18
#=GF DE   Arylesterase
#=GF AU   Bashton M, Bateman A, Fenech M
#=GF SE   Pfam-B_2101 (release 4.1)
#=GF GA   21.30 21.30;
#=GF TC   21.30 21.30;
#=GF NC   21.20 21.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   9032442
#=GF RT   Purification and characterization of paraoxon hydrolase from rat
#=GF RT   liver. 
#=GF RA   Rodrigo L, Gil F, Hernandez AF, Marina A, Vazquez J, Pla A; 
#=GF RL   Biochem J 1997;321:595-601.
#=GF RN   [2]
#=GF RM   8661009
#=GF RT   The human serum paraoxonase/arylesterase gene (PON1) is one
#=GF RT   member of a multigene family. 
#=GF RA   Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN; 
#=GF RL   Genomics 1996;33:498-507.
#=GF DR   INTERPRO; IPR002640;
#=GF CC   This family consists of arylesterases (Also known as serum
#=GF CC   paraoxonase) EC:3.1.1.2. These enzymes hydrolyse
#=GF CC   organophosphorus esters such as paraoxon and are found in the
#=GF CC   liver and blood. They confer resistance to organophosphate
#=GF CC   toxicity [1]. Human arylesterase (PON1) Swiss:P27169 is
#=GF CC   associated with HDL and may protect against LDL oxidation [2].
#=GF SQ   313
#=GS T5AN48_OPHSC/180-270      AC T5AN48.1
#=GS A0A074Y299_AURPU/197-263  AC A0A074Y299.1
#=GS F6R1T9_HORSE/167-252      AC F6R1T9.1
#=GS A0A0N4ZH65_PARTI/218-304  AC A0A0N4ZH65.1
#=GS A0A0M3I0Y6_ASCLU/164-219  AC A0A0M3I0Y6.1
#=GS W5NZ75_SHEEP/167-252      AC W5NZ75.1
#=GS M3WNF1_FELCA/168-253      AC M3WNF1.1
#=GS H0YTL8_TAEGU/180-265      AC H0YTL8.1
#=GS H2PMW1_PONAB/167-252      AC H2PMW1.1
#=GS G3SVE9_LOXAF/168-253      AC G3SVE9.1
#=GS M5CD90_THACB/96-175       AC M5CD90.1
#=GS A0A090LK74_STRRB/215-300  AC A0A090LK74.1
#=GS A0A0N4YF28_NIPBR/243-327  AC A0A0N4YF28.1
#=GS X0D430_FUSOX/97-187       AC X0D430.1
#=GS G3SEM7_GORGO/103-188      AC G3SEM7.1
#=GS A0A0A1MY91_9FUNG/195-276  AC A0A0A1MY91.1
#=GS M4A7G4_XIPMA/167-252      AC M4A7G4.1
#=GS G1S0R9_NOMLE/168-253      AC G1S0R9.1
#=GS A0A0G2IB89_9EURO/184-277  AC A0A0G2IB89.1
#=GS E3LMY2_CAERE/177-262      AC E3LMY2.1
#=GS G1P894_MYOLU/167-252      AC G1P894.1
#=GS F7H7J8_MACMU/168-253      AC F7H7J8.1
#=GS PON3_MOUSE/167-252        AC Q62087.2
#=GS E3LJL8_CAERE/164-247      AC E3LJL8.1
#=GS A0A096MWI7_PAPAN/167-252  AC A0A096MWI7.1
#=GS S0EHM1_GIBF5/206-303      AC S0EHM1.1
#=GS G3RBS0_GORGO/167-252      AC G3RBS0.1
#=GS W3XGS0_9PEZI/181-271      AC W3XGS0.1
#=GS U1NSI6_ASCSU/164-249      AC U1NSI6.1
#=GS W4Z8K2_STRPU/327-410      AC W4Z8K2.1
#=GS Q1JQD3_BOVIN/167-252      AC Q1JQD3.1
#=GS A0A0B4G7F5_9HYPO/201-251  AC A0A0B4G7F5.1
#=GS F7GMG3_CALJA/168-253      AC F7GMG3.1
#=GS I1CUB6_RHIO9/197-277      AC I1CUB6.1
#=GS PON2_HUMAN/167-252        AC Q15165.3
#=GS N4U128_FUSC1/180-270      AC N4U128.1
#=GS A0A0N4X6T0_HAEPC/144-229  AC A0A0N4X6T0.1
#=GS G3SVF4_LOXAF/169-254      AC G3SVF4.1
#=GS F1NCU9_CHICK/167-252      AC F1NCU9.2
#=GS A0A096N5F1_PAPAN/188-273  AC A0A096N5F1.1
#=GS G1KPD0_ANOCA/167-252      AC G1KPD0.2
#=GS C3Z0G1_BRAFL/124-212      AC C3Z0G1.1
#=GS F7F9H2_CALJA/168-253      AC F7F9H2.1
#=GS F7GXN7_CALJA/188-273      AC F7GXN7.1
#=GS H3EA06_PRIPA/128-213      AC H3EA06.1
#=GS W4Z8K2_STRPU/145-228      AC W4Z8K2.1
#=GS V8NP91_OPHHA/127-213      AC V8NP91.1
#=GS I3LBG8_PIG/46-131         AC I3LBG8.1
#=GS E0TI67_PARBH/162-246      AC E0TI67.1
#=GS A0A0G2HL39_9PEZI/205-293  AC A0A0G2HL39.1
#=GS A8X4W4_CAEBR/182-267      AC A8X4W4.2
#=GS U7PRB9_SPOS1/202-292      AC U7PRB9.1
#=GS G5AJS8_HETGA/167-252      AC G5AJS8.1
#=GS C3ZRT0_BRAFL/174-258      AC C3ZRT0.1
#=GS M5BYQ6_THACB/96-175       AC M5BYQ6.1
#=GS A0A0G2BAV5_9BACT/154-201  AC A0A0G2BAV5.1
#=GS G7P1C2_MACFA/188-273      AC G7P1C2.1
#=GS G1SN96_RABIT/151-236      AC G1SN96.2
#=GS G0NWF1_CAEBE/177-236      AC G0NWF1.1
#=GS H3G3X4_PRIPA/158-243      AC H3G3X4.1
#=GS X0D2T8_FUSOX/180-270      AC X0D2T8.1
#=GS W5NY46_SHEEP/168-253      AC W5NY46.1
#=GS F7AQC1_XENTR/190-275      AC F7AQC1.1
#=GS H2UWV6_TAKRU/167-253      AC H2UWV6.1
#=GS E4RYS4_LEAB4/149-232      AC E4RYS4.1
#=GS A0A0B2VD20_TOXCA/164-249  AC A0A0B2VD20.1
#=GS MEC6_CAEEL/178-263        AC O01811.2
#=GS G3QPZ3_GORGO/168-253      AC G3QPZ3.1
#=GS G1SGM3_RABIT/167-252      AC G1SGM3.1
#=GS H2LR36_ORYLA/167-252      AC H2LR36.1
#=GS X5MC90_9RHIZ/157-242      AC X5MC90.1
#=GS C3XSA7_BRAFL/141-226      AC C3XSA7.1
#=GS E9F8Q2_METRA/201-251      AC E9F8Q2.1
#=GS H0WYI6_OTOGA/167-252      AC H0WYI6.1
#=GS A0A0N4X6T1_HAEPC/63-149   AC A0A0N4X6T1.1
#=GS A0A087XEU8_POEFO/169-253  AC A0A087XEU8.1
#=GS A8XEG4_CAEBR/165-249      AC A8XEG4.1
#=GS F4P4M2_BATDJ/178-263      AC F4P4M2.1
#=GS I1BU08_RHIO9/196-276      AC I1BU08.1
#=GS A0A0N5B9Z5_STREA/215-300  AC A0A0N5B9Z5.1
#=GS I2EQ92_EMTOG/154-238      AC I2EQ92.1
#=GS E3MGE3_CAERE/23-107       AC E3MGE3.1
#=GS PON3_RABIT/167-252        AC Q9BGN0.1
#=GS M3XR63_MUSPF/168-253      AC M3XR63.1
#=GS M3WY75_FELCA/171-256      AC M3WY75.1
#=GS L9JFL0_TUPCH/168-253      AC L9JFL0.1
#=GS V4AID6_LOTGI/176-261      AC V4AID6.1
#=GS C3XS12_BRAFL/141-226      AC C3XS12.1
#=GS E9E749_METAQ/201-250      AC E9E749.1
#=GS G1PPG6_MYOLU/168-253      AC G1PPG6.1
#=GS PON1_MOUSE/168-253        AC P52430.2
#=GS G1S130_NOMLE/188-273      AC G1S130.1
#=GS M3W9B9_FELCA/167-252      AC M3W9B9.1
#=GS K1R245_CRAGI/140-225      AC K1R245.1
#=GS PON2_MOUSE/167-252        AC Q62086.2
#=GS G3XAK4_HUMAN/167-217      AC G3XAK4.1
#=GS H3G3X5_PRIPA/95-181       AC H3G3X5.1
#=GS W7MJ46_GIBM7/206-303      AC W7MJ46.1
#=GS I1GDS3_AMPQE/82-169       AC I1GDS3.1
#=GS W2RXS9_9EURO/10-104       AC W2RXS9.1
#=GS W4YZ77_STRPU/27-111       AC W4YZ77.1
#=GS H0WYI2_OTOGA/168-253      AC H0WYI2.1
#=GS A0A0K0ENE2_STRER/153-240  AC A0A0K0ENE2.1
#=GS I3J3S6_ORENI/167-253      AC I3J3S6.1
#=GS A0A091DM58_FUKDA/143-228  AC A0A091DM58.1
#=GS A1ZI43_9BACT/163-248      AC A1ZI43.1
#=GS W4XG87_STRPU/98-182       AC W4XG87.1
#=GS H9H6Y0_MONDO/259-344      AC H9H6Y0.2
#=GS A0A090LTI7_STRRB/153-239  AC A0A090LTI7.1
#=GS M4A7E2_XIPMA/166-249      AC M4A7E2.1
#=GS K1PUG0_CRAGI/542-622      AC K1PUG0.1
#=GS C9JZ99_HUMAN/167-237      AC C9JZ99.1
#=GS K3VLC5_FUSPC/177-266      AC K3VLC5.1
#=GS Q66JN5_DANRE/168-253      AC Q66JN5.1
#=GS W9VFS3_9EURO/188-277      AC W9VFS3.1
#=GS A0A0N4T9E8_BRUPA/19-106   AC A0A0N4T9E8.1
#=GS F7BR80_HORSE/153-238      AC F7BR80.1
#=GS PON3_RAT/167-252          AC Q68FP2.1
#=GS A0A0N4UWL4_ENTVE/141-210  AC A0A0N4UWL4.1
#=GS A0A096MTS0_PAPAN/168-253  AC A0A096MTS0.1
#=GS A0A0J9YXU7_HUMAN/81-113   AC A0A0J9YXU7.1
#=GS A0A087XF92_POEFO/167-252  AC A0A087XF92.1
#=GS H9H635_MONDO/144-229      AC H9H635.1
#=GS F0XI76_GROCL/212-286      AC F0XI76.1
#=GS A0A0J9WJD4_FUSO4/180-270  AC A0A0J9WJD4.1
#=GS F1R1X3_DANRE/168-253      AC F1R1X3.1
#=GS F8WD41_HUMAN/167-252      AC F8WD41.1
#=GS A0A0D9RKI3_CHLSB/168-253  AC A0A0D9RKI3.1
#=GS A0A067MRC5_9HOMO/183-277  AC A0A067MRC5.1
#=GS K1RAI0_CRAGI/341-426      AC K1RAI0.1
#=GS H2LR48_ORYLA/168-229      AC H2LR48.1
#=GS A0A0N4V407_ENTVE/133-189  AC A0A0N4V407.1
#=GS A0A0N5C0E9_STREA/153-238  AC A0A0N5C0E9.1
#=GS E7FFZ8_DANRE/168-253      AC E7FFZ8.2
#=GS A0A015N968_9GLOM/181-268  AC A0A015N968.1
#=GS A0A091CYU6_FUKDA/167-252  AC A0A091CYU6.1
#=GS M3XR56_MUSPF/167-252      AC M3XR56.1
#=GS W5MYF0_LEPOC/170-254      AC W5MYF0.1
#=GS A0A044RF18_ONCVO/110-195  AC A0A044RF18.1
#=GS H3DM81_TETNG/161-246      AC H3DM81.1
#=GS Q4WWG7_ASPFU/86-183       AC Q4WWG7.1
#=GS G1LUN9_AILME/167-252      AC G1LUN9.1
#=GS M7WJW0_RHOT1/194-281      AC M7WJW0.1
#=GS A0A0N4TFK3_BRUPA/89-142   AC A0A0N4TFK3.1
#=GS F7H7I9_MACMU/167-252      AC F7H7I9.1
#=GS X0L920_FUSOX/205-287      AC X0L920.1
#=GS PON2_RAT/167-252          AC Q6AXM8.1
#=GS N1RU17_FUSC4/205-287      AC N1RU17.1
#=GS N1RXC3_FUSC4/180-270      AC N1RXC3.1
#=GS C1GY16_PARBA/189-282      AC C1GY16.2
#=GS C7ZL65_NECH7/180-268      AC C7ZL65.1
#=GS A0A0N0DD05_9HYPO/210-307  AC A0A0N0DD05.1
#=GS E3ME28_CAERE/158-243      AC E3ME28.1
#=GS M3XR50_MUSPF/167-252      AC M3XR50.1
#=GS A0A0M3JUI0_ANISI/123-224  AC A0A0M3JUI0.1
#=GS A0A0J9YXF2_HUMAN/188-273  AC A0A0J9YXF2.1
#=GS G3RXU5_GORGO/167-252      AC G3RXU5.1
#=GS X5M752_9RHIZ/171-256      AC X5M752.1
#=GS L9JFQ0_TUPCH/154-239      AC L9JFQ0.1
#=GS W5MYF6_LEPOC/170-254      AC W5MYF6.1
#=GS F0U6Q6_AJEC8/148-238      AC F0U6Q6.1
#=GS Q2V071_CAEEL/165-249      AC Q2V071.2
#=GS G5ANL3_HETGA/163-248      AC G5ANL3.1
#=GS G7P1C3_MACFA/167-252      AC G7P1C3.1
#=GS E1FP11_LOALO/111-196      AC E1FP11.2
#=GS I3MXR0_ICTTR/167-252      AC I3MXR0.1
#=GS N4U338_FUSC1/206-303      AC N4U338.1
#=GS A0A063BY67_9HYPO/203-258  AC A0A063BY67.1
#=GS PON2_BOVIN/167-252        AC Q58DS7.1
#=GS PON3_HUMAN/167-252        AC Q15166.3
#=GS H2VVQ5_CAEJA/177-262      AC H2VVQ5.2
#=GS I3MI75_ICTTR/188-273      AC I3MI75.1
#=GS F7H7I7_MACMU/188-273      AC F7H7I7.1
#=GS G5AJS7_HETGA/167-252      AC G5AJS7.1
#=GS G7P1C5_MACFA/168-253      AC G7P1C5.1
#=GS W7I0M5_9PEZI/196-284      AC W7I0M5.1
#=GS A0A0N5A4B1_PARTI/591-676  AC A0A0N5A4B1.1
#=GS F1SFA2_PIG/167-252        AC F1SFA2.2
#=GS W4Z270_STRPU/164-249      AC W4Z270.1
#=GS T1F1D8_HELRO/121-201      AC T1F1D8.1
#=GS A0A0D9RKI9_CHLSB/167-252  AC A0A0D9RKI9.1
#=GS A6RBU7_AJECN/2334-2427    AC A6RBU7.1
#=GS H2QUY5_PANTR/168-253      AC H2QUY5.1
#=GS A7SC44_NEMVE/65-154       AC A7SC44.1
#=GS PON2_CHICK/167-252        AC Q90952.1
#=GS G3NYK1_GASAC/167-253      AC G3NYK1.1
#=GS A0A0K0FUX7_9BILA/215-300  AC A0A0K0FUX7.1
#=GS G0NJN6_CAEBE/142-226      AC G0NJN6.1
#=GS A3UFZ6_9RHOB/162-247      AC A3UFZ6.1
#=GS S0DY90_GIBF5/180-269      AC S0DY90.1
#=GS A0A074S820_9HOMO/150-248  AC A0A074S820.1
#=GS A0A091D071_FUKDA/167-252  AC A0A091D071.1
#=GS G3VTD9_SARHA/138-223      AC G3VTD9.1
#=GS A0A0K0G557_9BILA/153-237  AC A0A0K0G557.1
#=GS G0RIK2_HYPJQ/198-250      AC G0RIK2.1
#=GS U9SMQ0_RHIID/179-265      AC U9SMQ0.1
#=GS A0A0J9YYJ1_HUMAN/20-105   AC A0A0J9YYJ1.1
#=GS A0A0B2WKS6_9HYPO/203-302  AC A0A0B2WKS6.1
#=GS D5GPF6_TUBMM/199-293      AC D5GPF6.1
#=GS F1SFA1_PIG/143-228        AC F1SFA1.2
#=GS C0NNE6_AJECG/184-277      AC C0NNE6.1
#=GS H3G3X6_PRIPA/87-172       AC H3G3X6.1
#=GS W5L9U0_ASTMX/164-249      AC W5L9U0.1
#=GS F7FN35_CALJA/167-252      AC F7FN35.1
#=GS H3BL07_MOUSE/94-135       AC H3BL07.1
#=GS F7DTV1_HORSE/168-253      AC F7DTV1.1
#=GS H0V9N7_CAVPO/167-252      AC H0V9N7.1
#=GS PON1_RAT/168-253          AC P55159.3
#=GS M1VUT4_CLAP2/205-301      AC M1VUT4.1
#=GS B6Q2Y9_TALMQ/189-277      AC B6Q2Y9.1
#=GS T1G9J6_HELRO/132-219      AC T1G9J6.1
#=GS U3K6S4_FICAL/155-240      AC U3K6S4.1
#=GS F7D0R7_CALJA/167-252      AC F7D0R7.1
#=GS J3QT77_HUMAN/155-240      AC J3QT77.1
#=GS A0A0P7VMC2_9TELE/141-226  AC A0A0P7VMC2.1
#=GS A7HUX8_PARL1/170-254      AC A7HUX8.1
#=GS A0A0J9YYG4_HUMAN/167-252  AC A0A0J9YYG4.1
#=GS W5NYJ0_SHEEP/167-252      AC W5NYJ0.1
#=GS L9JEV2_TUPCH/117-202      AC L9JEV2.1
#=GS F1PSG5_CANLF/167-252      AC F1PSG5.2
#=GS PON1_RABIT/168-253        AC P27170.2
#=GS C6H335_AJECH/153-243      AC C6H335.1
#=GS H0XT87_OTOGA/167-252      AC H0XT87.1
#=GS G0SZZ5_RHOG2/194-281      AC G0SZZ5.1
#=GS A0A0N5CZC8_THECL/162-247  AC A0A0N5CZC8.1
#=GS G1S0T5_NOMLE/167-252      AC G1S0T5.1
#=GS G3SVF6_LOXAF/169-254      AC G3SVF6.1
#=GS X0L911_FUSOX/206-303      AC X0L911.1
#=GS Q8F8Z9_LEPIN/158-246      AC Q8F8Z9.1
#=GS L7UMD2_MYXSD/159-243      AC L7UMD2.1
#=GS A0A063BIE0_9HYPO/180-275  AC A0A063BIE0.1
#=GS I3J3S7_ORENI/165-250      AC I3J3S7.1
#=GS A0A068RM48_9FUNG/166-254  AC A0A068RM48.1
#=GS Q966L1_CAEEL/166-250      AC Q966L1.1
#=GS A7S5F8_NEMVE/68-158       AC A7S5F8.1
#=GS M7TQT4_EUTLA/214-310      AC M7TQT4.1
#=GS A0A016PY32_GIBZA/177-266  AC A0A016PY32.1
#=GS G1NBB7_MELGA/147-232      AC G1NBB7.1
#=GS S2JAF2_MUCC1/209-290      AC S2JAF2.1
#=GS F2TKH2_AJEDA/184-277      AC F2TKH2.1
#=GS C1G7L5_PARBD/183-276      AC C1G7L5.1
#=GS H3BK03_MOUSE/145-186      AC H3BK03.7
#=GS W5MYG9_LEPOC/168-252      AC W5MYG9.1
#=GS F9FCJ8_FUSOF/560-650      AC F9FCJ8.1
#=GS E2RPW3_CANLF/168-253      AC E2RPW3.2
#=GS C3Z2J4_BRAFL/171-256      AC C3Z2J4.1
#=GS G0NZH2_CAEBE/177-262      AC G0NZH2.1
#=GS X0IUB7_FUSOX/243-333      AC X0IUB7.1
#=GS D5GAR4_TUBMM/179-274      AC D5GAR4.1
#=GS L5KPF4_PTEAL/236-321      AC L5KPF4.1
#=GS W9WN26_9EURO/192-281      AC W9WN26.1
#=GS C3Z2J1_BRAFL/141-226      AC C3Z2J1.1
#=GS G1P8A7_MYOLU/188-273      AC G1P8A7.1
#=GS H2PMW2_PONAB/168-253      AC H2PMW2.1
#=GS A0A0D9RKJ8_CHLSB/167-252  AC A0A0D9RKJ8.1
#=GS PON1_HUMAN/168-253        AC P27169.3
#=GS PON1_HUMAN/168-253        DR PDB; 1V04 A; 168-253;
#=GS U6NUW3_HAECO/165-250      AC U6NUW3.1
#=GS H3DV59_PRIPA/166-251      AC H3DV59.1
#=GS M7C0P8_CHEMY/167-252      AC M7C0P8.1
#=GS G1LUR9_AILME/168-253      AC G1LUR9.1
#=GS I3MI68_ICTTR/168-253      AC I3MI68.1
#=GS A0A0D2Y606_FUSO4/206-303  AC A0A0D2Y606.1
#=GS H2PMW0_PONAB/188-273      AC H2PMW0.2
#=GS H3DM82_TETNG/166-252      AC H3DM82.1
#=GS H2ZVI0_LATCH/169-254      AC H2ZVI0.1
#=GS V5G7L8_BYSSN/183-275      AC V5G7L8.1
#=GS A4ASP8_MARSH/157-243      AC A4ASP8.1
#=GS S7QDT4_GLOTA/190-276      AC S7QDT4.1
#=GS A0A0M9EU64_9HYPO/177-266  AC A0A0M9EU64.1
#=GS H3EA05_PRIPA/88-173       AC H3EA05.1
#=GS A0A015L8L1_9GLOM/179-265  AC A0A015L8L1.1
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