GenomeNet

Database: Pfam
Entry: Arylesterase
LinkDB: Arylesterase
Original site: Arylesterase 
#=GF ID   Arylesterase
#=GF AC   PF01731.16
#=GF DE   Arylesterase
#=GF AU   Bashton M, Bateman A, Fenech M
#=GF SE   Pfam-B_2101 (release 4.1)
#=GF GA   21.30 21.30;
#=GF TC   21.30 21.30;
#=GF NC   21.20 21.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   9032442
#=GF RT   Purification and characterization of paraoxon hydrolase from rat
#=GF RT   liver. 
#=GF RA   Rodrigo L, Gil F, Hernandez AF, Marina A, Vazquez J, Pla A; 
#=GF RL   Biochem J 1997;321:595-601.
#=GF RN   [2]
#=GF RM   8661009
#=GF RT   The human serum paraoxonase/arylesterase gene (PON1) is one
#=GF RT   member of a multigene family. 
#=GF RA   Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN; 
#=GF RL   Genomics 1996;33:498-507.
#=GF DR   INTERPRO; IPR002640;
#=GF CC   This family consists of arylesterases (Also known as serum
#=GF CC   paraoxonase) EC:3.1.1.2. These enzymes hydrolyse
#=GF CC   organophosphorus esters such as paraoxon and are found in the
#=GF CC   liver and blood. They confer resistance to organophosphate
#=GF CC   toxicity [1]. Human arylesterase (PON1) Swiss:P27169 is
#=GF CC   associated with HDL and may protect against LDL oxidation [2].
#=GF SQ   454
#=GS N1VLE9_LEPIT/158-246      AC N1VLE9.1
#=GS Q72VF0_LEPIC/158-246      AC Q72VF0.1
#=GS W4Z8K2_STRPU/145-228      AC W4Z8K2.1
#=GS X0D2T8_FUSOX/180-270      AC X0D2T8.1
#=GS MEC6_CAEEL/178-263        AC O01811.2
#=GS I2EQ92_EMTOG/154-238      AC I2EQ92.1
#=GS M6NI84_LEPIR/158-246      AC M6NI84.1
#=GS X8J640_9HOMO/150-248      AC X8J640.1
#=GS M3HKH8_LEPIR/74-162       AC M3HKH8.1
#=GS W4YZ77_STRPU/27-111       AC W4YZ77.1
#=GS C9JZ99_HUMAN/167-237      AC C9JZ99.1
#=GS A0A016VEY5_9BILA/146-231  AC A0A016VEY5.1
#=GS K8HCE9_9LEPT/158-246      AC K8HCE9.1
#=GS E3ME28_CAERE/158-243      AC E3ME28.1
#=GS L8HQI7_9CETA/167-252      AC L8HQI7.1
#=GS B1PK14_PIG/167-252        AC B1PK14.1
#=GS B4DKM6_HUMAN/176-261      AC B4DKM6.1
#=GS W5L9U0_ASTMX/164-249      AC W5L9U0.1
#=GS PON1_RAT/168-253          AC P55159.3
#=GS X0AW44_FUSOX/180-270      AC X0AW44.1
#=GS A7HUX8_PARL1/170-254      AC A7HUX8.1
#=GS I3J3S7_ORENI/165-250      AC I3J3S7.1
#=GS T5BDG6_AJEDE/184-277      AC T5BDG6.1
#=GS X0IUB7_FUSOX/243-333      AC X0IUB7.1
#=GS D5GAR4_TUBMM/179-274      AC D5GAR4.1
#=GS C3Z2J1_BRAFL/141-226      AC C3Z2J1.1
#=GS PON1_HUMAN/168-253        AC P27169.3
#=GS PON1_HUMAN/168-253        DR PDB; 1V04 A; 168-253;
#=GS U6DUG4_NEOVI/100-185      AC U6DUG4.1
#=GS PON2_MELGA/167-252        AC Q91090.1
#=GS D2HAP6_AILME/104-189      AC D2HAP6.1
#=GS H3BK03_MOUSE/145-186      AC H3BK03.2
#=GS I3AJJ3_SERPL/148-226      AC I3AJJ3.1
#=GS M5CD90_THACB/96-175       AC M5CD90.1
#=GS M5Y2U8_LEPIR/158-246      AC M5Y2U8.1
#=GS Q4RHU2_TETNG/67-153       AC Q4RHU2.1
#=GS K9IJP4_DESRO/167-251      AC K9IJP4.1
#=GS F1NCU9_CHICK/167-252      AC F1NCU9.2
#=GS C3ZRT0_BRAFL/174-258      AC C3ZRT0.1
#=GS F7AQC1_XENTR/190-275      AC F7AQC1.1
#=GS K6IH48_LEPIR/158-246      AC K6IH48.1
#=GS M6UGZ0_9LEPT/155-243      AC M6UGZ0.1
#=GS PON3_RABIT/167-252        AC Q9BGN0.1
#=GS X0H7K9_FUSOX/206-303      AC X0H7K9.1
#=GS W4XG87_STRPU/98-182       AC W4XG87.1
#=GS K1PUG0_CRAGI/542-622      AC K1PUG0.1
#=GS S0AAX8_SERPL/149-226      AC S0AAX8.1
#=GS A0A044RF18_ONCVO/110-195  AC A0A044RF18.1
#=GS I3MI75_SPETR/188-273      AC I3MI75.1
#=GS W7N4A6_9ENTR/148-230      AC W7N4A6.1
#=GS S0DY90_GIBF5/180-269      AC S0DY90.1
#=GS K6FD21_9LEPT/158-246      AC K6FD21.1
#=GS X0FNK9_FUSOX/243-333      AC X0FNK9.1
#=GS F1PSG5_CANFA/167-252      AC F1PSG5.2
#=GS K6U0X6_LEPIR/144-232      AC K6U0X6.1
#=GS L5KPF4_PTEAL/236-321      AC L5KPF4.1
#=GS U6NUW3_HAECO/165-250      AC U6NUW3.1
#=GS I3MI68_SPETR/168-253      AC I3MI68.1
#=GS H2ZVI0_LATCH/169-254      AC H2ZVI0.1
#=GS A4ASP8_MARSH/157-243      AC A4ASP8.1
#=GS S7QDT4_GLOTA/190-276      AC S7QDT4.1
#=GS T5AKH8_OPHSC/204-251      AC T5AKH8.1
#=GS W9PT41_FUSOX/180-270      AC W9PT41.1
#=GS U3BKB0_CALJA/167-252      AC U3BKB0.1
#=GS G3SVE9_LOXAF/168-253      AC G3SVE9.1
#=GS J9N949_FUSO4/206-303      AC J9N949.1
#=GS I1RUL9_GIBZE/177-266      AC I1RUL9.1
#=GS W4Z8K2_STRPU/327-410      AC W4Z8K2.1
#=GS W9MX19_FUSOX/206-303      AC W9MX19.1
#=GS I1CUB6_RHIO9/197-277      AC I1CUB6.1
#=GS M6KQH1_LEPIR/158-246      AC M6KQH1.1
#=GS E9F8Q2_METAR/201-251      AC E9F8Q2.1
#=GS S7PSM7_MYOBR/157-242      AC S7PSM7.1
#=GS M6YF90_LEPIR/158-246      AC M6YF90.1
#=GS PON1_MOUSE/168-253        AC P52430.2
#=GS M6SIU3_LEPIT/158-246      AC M6SIU3.1
#=GS A9XLQ9_PIG/93-178         AC A9XLQ9.1
#=GS M6BD19_LEPIR/144-232      AC M6BD19.1
#=GS H9F4U7_MACMU/152-237      AC H9F4U7.1
#=GS J4JRJ5_LEPIR/158-246      AC J4JRJ5.1
#=GS K1RAI0_CRAGI/341-426      AC K1RAI0.1
#=GS C7ZL65_NECH7/180-268      AC C7ZL65.1
#=GS K8JQJ0_LEPIR/144-232      AC K8JQJ0.1
#=GS A4US67_PIG/168-253        AC A4US67.2
#=GS G7P1C5_MACFA/168-253      AC G7P1C5.1
#=GS U3TAD0_PROFL/1-36         AC U3TAD0.1
#=GS A0A016VE43_9BILA/150-235  AC A0A016VE43.1
#=GS H3BL07_MOUSE/94-135       AC H3BL07.1
#=GS F7FN35_CALJA/167-252      AC F7FN35.1
#=GS W9JVG9_FUSOX/206-303      AC W9JVG9.1
#=GS K6TC89_LEPIR/158-246      AC K6TC89.1
#=GS W5NYJ0_SHEEP/167-252      AC W5NYJ0.1
#=GS M6R1S1_LEPIR/158-246      AC M6R1S1.1
#=GS G3HT85_CRIGR/168-253      AC G3HT85.1
#=GS Q2KIW1_BOVIN/168-253      AC Q2KIW1.1
#=GS L5KNP4_PTEAL/167-252      AC L5KNP4.1
#=GS G3HT86_CRIGR/167-252      AC G3HT86.1
#=GS M6IL92_LEPIR/144-232      AC M6IL92.1
#=GS C6W5H6_DYAFD/213-277      AC C6W5H6.1
#=GS Q6IRR7_XENLA/168-253      AC Q6IRR7.1
#=GS A7MCN3_DANRE/168-253      AC A7MCN3.1
#=GS W9KSV5_FUSOX/243-333      AC W9KSV5.1
#=GS X0HMH5_FUSOX/243-333      AC X0HMH5.1
#=GS M4A7G4_XIPMA/167-252      AC M4A7G4.1
#=GS C3Z0G1_BRAFL/124-212      AC C3Z0G1.1
#=GS B4E2I0_HUMAN/215-280      AC B4E2I0.1
#=GS E4RYS4_LEAB4/149-232      AC E4RYS4.1
#=GS G1SGM3_RABIT/167-252      AC G1SGM3.1
#=GS L9JFL0_TUPCH/168-253      AC L9JFL0.1
#=GS M3W9B9_FELCA/167-252      AC M3W9B9.1
#=GS R7VIG4_CAPTE/134-217      AC R7VIG4.1
#=GS F0XI76_GROCL/212-286      AC F0XI76.1
#=GS H3DM81_TETNG/161-246      AC H3DM81.1
#=GS G1LUN9_AILME/167-252      AC G1LUN9.1
#=GS N1RU17_FUSC4/205-287      AC N1RU17.1
#=GS F0U6Q6_AJEC8/148-238      AC F0U6Q6.1
#=GS G7QJS5_LEPII/158-246      AC G7QJS5.1
#=GS U9SMQ0_RHIID/179-265      AC U9SMQ0.1
#=GS H0V9N7_CAVPO/167-252      AC H0V9N7.1
#=GS U3K6S4_FICAL/155-240      AC U3K6S4.1
#=GS X0L911_FUSOX/206-303      AC X0L911.1
#=GS M3HEN0_LEPIT/158-246      AC M3HEN0.1
#=GS M6NAK8_LEPIR/144-232      AC M6NAK8.1
#=GS A0A016PY32_GIBZA/177-266  AC A0A016PY32.1
#=GS S9XD70_9CETA/167-252      AC S9XD70.1
#=GS E3LMY2_CAERE/177-262      AC E3LMY2.1
#=GS E3LJL8_CAERE/164-247      AC E3LJL8.1
#=GS N4U128_FUSC1/180-270      AC N4U128.1
#=GS G3SVF4_LOXAF/169-254      AC G3SVF4.1
#=GS R7UZD7_CAPTE/158-241      AC R7UZD7.1
#=GS H3EA06_PRIPA/128-213      AC H3EA06.1
#=GS G3QPZ3_GORGO/168-253      AC G3QPZ3.1
#=GS W9P0H9_FUSOX/206-303      AC W9P0H9.1
#=GS C3KHZ1_ANOFI/165-250      AC C3KHZ1.1
#=GS G3XAK4_HUMAN/167-217      AC G3XAK4.1
#=GS H0WYI2_OTOGA/168-253      AC H0WYI2.1
#=GS K3VLC5_FUSPC/177-266      AC K3VLC5.1
#=GS G9KHV1_MUSPF/169-254      AC G9KHV1.1
#=GS A0A015N968_9GLOM/181-268  AC A0A015N968.1
#=GS PON2_RAT/167-252          AC Q6AXM8.1
#=GS K8LC77_LEPIR/158-246      AC K8LC77.1
#=GS X5M752_9BACT/171-256      AC X5M752.1
#=GS G7P1C3_MACFA/167-252      AC G7P1C3.1
#=GS PON2_BOVIN/167-252        AC Q58DS7.1
#=GS C5JE16_AJEDS/184-277      AC C5JE16.1
#=GS T1G9J6_HELRO/132-219      AC T1G9J6.1
#=GS J3QT77_HUMAN/155-240      AC J3QT77.1
#=GS F6KQD9_PIG/167-252        AC F6KQD9.1
#=GS E2RPW3_CANFA/168-253      AC E2RPW3.2
#=GS H3DM82_TETNG/166-252      AC H3DM82.1
#=GS M6F2Q8_LEPIR/144-232      AC M6F2Q8.1
#=GS H2QUY6_PANTR/188-273      AC H2QUY6.1
#=GS Q21427_CAEEL/158-243      AC Q21427.2
#=GS T5AN48_OPHSC/180-270      AC T5AN48.1
#=GS Q7ZTN3_XENLA/169-254      AC Q7ZTN3.1
#=GS A0A022T1C3_LEPIR/158-246  AC A0A022T1C3.1
#=GS S7N9H0_MYOBR/101-182      AC S7N9H0.1
#=GS K6FQP6_LEPIR/158-246      AC K6FQP6.1
#=GS H2UWV6_TAKRU/167-253      AC H2UWV6.1
#=GS PON2_MOUSE/167-252        AC Q62086.2
#=GS I1GDS3_AMPQE/82-169       AC I1GDS3.1
#=GS W9MEU1_FUSOX/243-333      AC W9MEU1.1
#=GS B2LSM4_SHEEP/167-252      AC B2LSM4.1
#=GS K6FNV0_LEPIR/144-232      AC K6FNV0.1
#=GS G3RXU5_GORGO/167-252      AC G3RXU5.1
#=GS W5MYF6_LEPOC/170-254      AC W5MYF6.1
#=GS G0RIK2_HYPJQ/198-250      AC G0RIK2.1
#=GS B6Q2Y9_PENMQ/189-277      AC B6Q2Y9.1
#=GS Q8MJU7_PONPY/2-66         AC Q8MJU7.1
#=GS J5KPV2_9GAMM/235-321      AC J5KPV2.1
#=GS Q98TN1_PLAFE/1-74         AC Q98TN1.1
#=GS W7PIN1_9ENTR/148-230      AC W7PIN1.1
#=GS G0NZH2_CAEBE/177-262      AC G0NZH2.1
#=GS G0C869_9ENTR/148-227      AC G0C869.1
#=GS G1LUR9_AILME/168-253      AC G1LUR9.1
#=GS M6GZY0_LEPIR/158-246      AC M6GZY0.1
#=GS A0A015L8L1_9GLOM/179-265  AC A0A015L8L1.1
#=GS H9H6Y1_MONDO/249-334      AC H9H6Y1.2
#=GS K8IPN6_LEPIR/158-246      AC K8IPN6.1
#=GS V6GHE4_9LEPT/155-243      AC V6GHE4.1
#=GS U9U273_RHIID/181-268      AC U9U273.1
#=GS W5NZ75_SHEEP/167-252      AC W5NZ75.1
#=GS G3SEM7_GORGO/103-188      AC G3SEM7.1
#=GS G0BU59_9ENTR/148-227      AC G0BU59.1
#=GS K6IAE8_LEPIR/158-246      AC K6IAE8.1
#=GS V8NP91_OPHHA/127-213      AC V8NP91.1
#=GS I3LBG8_PIG/46-131         AC I3LBG8.1
#=GS E0TI67_PARBH/162-246      AC E0TI67.1
#=GS X0G6P8_FUSOX/206-303      AC X0G6P8.1
#=GS F4P4M2_BATDJ/178-263      AC F4P4M2.1
#=GS E3MGE3_CAERE/23-107       AC E3MGE3.1
#=GS V4AID6_LOTGI/176-261      AC V4AID6.1
#=GS G1PPG6_MYOLU/168-253      AC G1PPG6.1
#=GS I3J3S6_ORENI/167-253      AC I3J3S6.1
#=GS S7NBX4_MYOBR/168-253      AC S7NBX4.1
#=GS M6QYZ2_LEPIR/158-246      AC M6QYZ2.1
#=GS M6XQW2_9LEPT/158-246      AC M6XQW2.1
#=GS K6EB56_LEPIR/144-232      AC K6EB56.1
#=GS M6F703_9LEPT/158-246      AC M6F703.1
#=GS R7VII0_CAPTE/158-240      AC R7VII0.1
#=GS A7SC44_NEMVE/65-154       AC A7SC44.1
#=GS M6NR57_LEPIR/158-246      AC M6NR57.1
#=GS M5V802_LEPIR/158-246      AC M5V802.1
#=GS M1VUT4_CLAP2/205-301      AC M1VUT4.1
#=GS B5XFU3_SALSA/169-254      AC B5XFU3.1
#=GS K6HZ32_9LEPT/158-246      AC K6HZ32.1
#=GS M7AEA4_LEPIR/158-246      AC M7AEA4.1
#=GS F2TKH2_AJEDA/184-277      AC F2TKH2.1
#=GS C3Z2J4_BRAFL/171-256      AC C3Z2J4.1
#=GS H2PMW0_PONAB/188-273      AC H2PMW0.2
#=GS M6DVZ3_9LEPT/158-246      AC M6DVZ3.1
#=GS K8I787_9LEPT/158-246      AC K8I787.1
#=GS M6ELD0_9LEPT/158-246      AC M6ELD0.1
#=GS U1MM95_ASCSU/199-284      AC U1MM95.1
#=GS K8JMP3_LEPIR/158-246      AC K8JMP3.1
#=GS I6R6P7_ENTCL/148-230      AC I6R6P7.1
#=GS M6BQZ4_LEPIR/144-232      AC M6BQZ4.1
#=GS PON3_MOUSE/167-252        AC Q62087.2
#=GS W5NY46_SHEEP/168-253      AC W5NY46.1
#=GS M6I899_9LEPT/158-246      AC M6I899.1
#=GS A0A024SDB5_HYPJE/198-250  AC A0A024SDB5.1
#=GS M6PC05_LEPIR/158-246      AC M6PC05.1
#=GS K6HVT1_9LEPT/158-246      AC K6HVT1.1
#=GS B4DW02_HUMAN/188-273      AC B4DW02.1
#=GS W7MJ46_GIBM7/206-303      AC W7MJ46.1
#=GS W2RXS9_9EURO/10-104       AC W2RXS9.1
#=GS K6K4B2_9LEPT/158-246      AC K6K4B2.1
#=GS L8HSZ4_9CETA/168-253      AC L8HSZ4.1
#=GS K8L348_9LEPT/155-243      AC K8L348.1
#=GS M6RA27_LEPIR/158-246      AC M6RA27.1
#=GS N4U338_FUSC1/206-303      AC N4U338.1
#=GS V6GTX5_9LEPT/155-243      AC V6GTX5.1
#=GS H0XT87_OTOGA/167-252      AC H0XT87.1
#=GS C1G7L5_PARBD/183-276      AC C1G7L5.1
#=GS T1BVT0_9ZZZZ/78-159       AC T1BVT0.1
#=GS M7C0P8_CHEMY/167-252      AC M7C0P8.1
#=GS M6WJY9_9LEPT/158-246      AC M6WJY9.1
#=GS T2MGW8_HYDVU/168-256      AC T2MGW8.1
#=GS A8XEG5_CAEBR/166-250      AC A8XEG5.1
#=GS G3HT86_CRIGR/333-377      AC G3HT86.1
#=GS K6Q438_LEPIR/158-246      AC K6Q438.1
#=GS F6KQD8_PIG/167-252        AC F6KQD8.1
#=GS C0RZ72_PARBP/183-276      AC C0RZ72.1
#=GS F6R1T9_HORSE/167-252      AC F6R1T9.1
#=GS W9ZMG5_FUSOX/206-303      AC W9ZMG5.1
#=GS M3WNF1_FELCA/168-253      AC M3WNF1.1
#=GS G1S0R9_NOMLE/168-253      AC G1S0R9.1
#=GS R0LPL1_ANAPL/108-193      AC R0LPL1.1
#=GS M3E0B5_LEPIR/158-246      AC M3E0B5.1
#=GS U1NSI6_ASCSU/164-249      AC U1NSI6.1
#=GS U6DUW6_NEOVI/9-94         AC U6DUW6.1
#=GS F7F9H2_CALJA/168-253      AC F7F9H2.1
#=GS G5AJS8_HETGA/167-252      AC G5AJS8.1
#=GS G0BCB1_SERSA/148-227      AC G0BCB1.1
#=GS G0NWF1_CAEBE/177-236      AC G0NWF1.1
#=GS E7FFZ8_DANRE/168-253      AC E7FFZ8.1
#=GS H9ER96_MACMU/155-240      AC H9ER96.1
#=GS D2HAP7_AILME/103-188      AC D2HAP7.1
#=GS M6JTB5_9LEPT/158-246      AC M6JTB5.1
#=GS V9KFS1_CALMI/167-252      AC V9KFS1.1
#=GS K7GHS4_PELSI/147-232      AC K7GHS4.1
#=GS M7WJW0_RHOT1/194-281      AC M7WJW0.1
#=GS N1RXC3_FUSC4/180-270      AC N1RXC3.1
#=GS G5ANL3_HETGA/163-248      AC G5ANL3.1
#=GS W7I0M5_9PEZI/196-284      AC W7I0M5.1
#=GS F1SFA2_PIG/167-252        AC F1SFA2.2
#=GS T1F1D8_HELRO/121-201      AC T1F1D8.1
#=GS S4YG93_SERPL/148-225      AC S4YG93.1
#=GS G3VTD9_SARHA/138-223      AC G3VTD9.1
#=GS C6H335_AJECH/153-243      AC C6H335.1
#=GS Q966L1_CAEEL/166-250      AC Q966L1.1
#=GS F9FCJ8_FUSOF/560-650      AC F9FCJ8.1
#=GS V8FWB9_CLOPA/1-46         AC V8FWB9.1
#=GS A8XGE3_CAEBR/177-262      AC A8XGE3.1
#=GS U3J5N7_ANAPL/166-251      AC U3J5N7.1
#=GS S0EHM1_GIBF5/206-303      AC S0EHM1.1
#=GS Q6DF09_XENTR/168-253      AC Q6DF09.1
#=GS G1KPD0_ANOCA/167-252      AC G1KPD0.2
#=GS A8X4W4_CAEBR/182-267      AC A8X4W4.2
#=GS H0WYI6_OTOGA/167-252      AC H0WYI6.1
#=GS N1V0D4_LEPIR/74-162       AC N1V0D4.1
#=GS H3G3X5_PRIPA/95-181       AC H3G3X5.1
#=GS F7BR80_HORSE/153-238      AC F7BR80.1
#=GS H2LR48_ORYLA/168-229      AC H2LR48.1
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N1VLE9_LEPIT/158-246                 ..........................................NDLSVVSENEIYLSND..H.GK...G...N.......I...L...R..Y....L.W.D.D......L..F.Q..I..K..R.SE.IS...Y...Y...........D...........G....K.....T......W....S....N...L...G.N...P...L...S......FGNGIL......YT..KD...S....QgneFLYRSG..YMDQSVFQFQI---rre.....................................................
Q72VF0_LEPIC/158-246                 ..........................................NDLSVVSENEIYLSND..H.GK...G...N.......I...L...R..Y....L.W.D.D......L..F.Q..I..K..R.SE.IS...Y...Y...........D...........G....K.....T......W....S....N...L...G.N...P...L...S......FGNGIL......YT..KD...S....QgneFLYRSG..YMDQSVFQFQI---rre.....................................................
W4Z8K2_STRPU/145-228                 .........................................s-DVLAVGSDQFYVTNQ..A.YS...L...D.......P...G...G..R....L.F.E.H......Y..M.M..F..P..W.GS.VL...Y...C...........D...........P....S.....-......C....R....L...V...S.N...A...I...F......EPSGIH......MS..PD...R....K...YVYVSL..LYGMGVHGYKR---dp......................................................
X0D2T8_FUSOX/180-270                 .........................................n-SIASVNGHEFYVTND..H.YI...T...K.......KqslL...L..S....N.L.E.T......Y..L.G..P..P..T.GT.VV...H...V...........Nl.........kA....S.....D......L....D...vR...V...V.A...W...V...P......FANGIE......IL..-N...S....S...TVAVAS..SSRAAIYMFN----tsda....................................................
MEC6_CAEEL/178-263                   ..........................................QDIAVVGPDRLFVTNM..A.AF...G...R.......G...W...A..Q....I.L.E.F......S..L.Q..T..G..Q.GA.VY...Y...Y...........D...........G....S.....K......L....S....T...A...A.S...S...L...I......APTGIG......YD..AK...R....R...ILYVGS..MIRESIFAYKVAKD........................................................
I2EQ92_EMTOG/154-238                 ..........................................NDVTAVGEHAFYVTND..H.DE...P...K.......S...S...W..R....D.K.K.D......L..L.Q..V..P..M.GN.VC...Y...Y...........D...........G....Q.....R......A....K....I...V...A.D...G...F...L......YANGIT......PS..LD...G....R...QIFVAA..TSGRKIKVYD----rdf.....................................................
M6NI84_LEPIR/158-246                 ..........................................NDLSVVSENEIYLSND..H.GK...G...N.......I...L...R..Y....L.W.D.D......L..F.Q..I..K..R.SE.IS...Y...Y...........D...........G....K.....T......W....S....N...L...G.N...P...L...S......FGNGIL......YT..KD...S....QgneFLYRSG..YMDQSVFQFQI---rre.....................................................
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M3HKH8_LEPIR/74-162                  ..........................................NDLSVVSENEIYLSND..H.GK...G...N.......I...L...R..Y....L.W.D.D......L..F.Q..I..K..R.SE.IS...Y...Y...........D...........G....K.....T......W....S....N...L...G.N...P...L...S......FGNGIL......YT..KD...S....QgneFLYRSG..YMDQSVFQFQI---rre.....................................................
W4YZ77_STRPU/27-111                  ..........................................NDVVLVDENRFYTTND..A.YL...P...Q.......P...F...-..N....I.L.E.V......V..F.R..L..S..S.GS.VA...Y...Y...........D...........G....H.....D......A....R....I...V...A.K...G...L...K......LSNGVN......LS..PN...K....K...LLYAAS..SLGQELFIYRVQSD........................................................
C9JZ99_HUMAN/167-237                 ..........................................NDIVVLGPEQFYATRD..H.YF...T...N.......S...L...L..S....F.F.E.M......I..L.D..L..R..W.TY.VL...F...Y...........S...........P....R.....E......V....K....V...V...A.K...G...F...C......SANGIT......VS..AD...Q....K...Y-----..--------------fasr....................................................
A0A016VEY5_9BILA/146-231             ..........................................NDLVAVSEEAFILSND..G.SA...Q...T.......T...V...T..N....L.L.E.I......L..S.M..I..P..S.GS.VV...Y...Y...........D...........G....K.....K......S....S....W...L...I.P...R...T...T......SPNGVI......LD..RE...R....K...HLIVSH..INDETLSVYKIG--en......................................................
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L8HQI7_9CETA/167-252                 ..........................................NDIVVLGPEQFYATRD..H.YF...T...N.......F...F...L..V....L.L.E.W......F..M.D..L..R..W.TQ.VL...F...Y...........S...........P....K.....E......V....K....V...V...A.R...G...F...S......SANGIT......IS..LD...K....K...YIYVAD..VSDKNIHVMKIHDN........................................................
B1PK14_PIG/167-252                   ..........................................NDIIAVGPAHFYATND..H.YF...S...D.......P...F...L..K....Y.L.E.T......Y..L.N..L..H..W.TN.VV...Y...Y...........S...........P....N.....E......V....K....V...V...A.E...G...F...D......SANGIN......IS..PD...K....K...YIYVAD..ILAHEIHVLEKQP-n.......................................................
B4DKM6_HUMAN/176-261                 ..........................................NDITAVGPAHFYATND..H.YF...S...D.......P...F...L..K....Y.L.E.T......Y..L.N..L..H..W.AN.VV...Y...Y...........S...........P....N.....E......V....K....V...V...A.E...G...F...D......SANGIN......IS..PD...D....K...YIYVAD..ILAHEIHVLEKHTN........................................................
W5L9U0_ASTMX/164-249                 ..........................................NDIVAVGVDSFYATND..Y.YF...T...N.......H...I...L..R....T.L.E.P......L..M.S..L..T..W.CN.VV...Y...Y...........S...........P....N.....E......V....R....S...V...S.E...G...Y...P......SANGIN......IS..PD...K....R...YLYVSD..ILRHRIGVLEIQKD........................................................
PON1_RAT/168-253                     ..........................................NDIAAVGPESFYATND..H.YF...A...D.......P...Y...L..R....S.W.E.M......Y..L.G..L..S..W.SN.VV...Y...Y...........S...........P....D.....K......V....R....V...V...A.D...G...F...D......FANGIG......IS..LD...G....K...YVYIAE..LLAHKIHVYEKHAN........................................................
X0AW44_FUSOX/180-270                 .........................................n-SIASVNGHEFYVTND..H.YI...T...K.......KqslL...L..S....N.L.E.T......Y..L.G..P..P..T.GT.VV...H...V...........Nl.........kA....S.....D......L....D...vR...V...V.A...W...V...P......FANGIE......IL..-N...S....S...TVAVAS..SSRAAIYMFN----tsda....................................................
A7HUX8_PARL1/170-254                 ..........................................NDVVGVGTDSFYATND..H.GS...-...G.......G...I...S..R....M.L.D.D......A..L.L..L..R..N.AN.VV...Y...F...........D...........G....E.....A......A....R....I...A...A.D...T...L...S......YPNGVN......VS..PD...G....A...TLYVAS..TLGMSLNIYKRD--te......................................................
I3J3S7_ORENI/165-250                 ..........................................NDIVAVGVESFYATND..R.YF...H...S.......D...A...L..L....L.V.A.V......F..L.D..L..T..W.CD.VV...F...Y...........S...........P....H.....E......V....R....M...V...A.D...G...L...R......SPNGIN......LS..PD...K....R...YIYVSD..IMDHDIDVFERQ--eg......................................................
T5BDG6_AJEDE/184-277                 .........................................n-SIAPVSYTQFYVTND..H.RYmarT...R.......P...F...W..N....K.I.E.T......S..F.S..M..P..W.SW.VA...Fv.dF..........sS...........P....E.....D......L....K....Cv.iV...A.S...N...I...A......FTNGII......VT..PT...G....K...EVIVAS..SGSDAVYVYER---dpq.....................................................
X0IUB7_FUSOX/243-333                 .........................................n-SIASVNGHEFYVTND..H.YI...T...K.......KqslL...L..S....N.L.E.T......Y..L.G..P..P..T.GT.VV...H...V...........Nl.........kA....S.....D......L....D...vR...V...V.A...W...V...P......FANGIE......IL..-N...S....S...TVAVAS..SSRAAIYMFN----tsda....................................................
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