GenomeNet

Database: Pfam
Entry: Aurora-A_bind
LinkDB: Aurora-A_bind
Original site: Aurora-A_bind 
#=GF ID   Aurora-A_bind
#=GF AC   PF09041.8
#=GF DE   Aurora-A binding 
#=GF AU   Mistry J, Sammut SJ
#=GF SE   pdb_1ol5
#=GF GA   20.20 20.20;
#=GF TC   21.30 21.00;
#=GF NC   20.10 20.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   14580337
#=GF RT   Structural basis of Aurora-A activation by TPX2 at the mitotic
#=GF RT   spindle. 
#=GF RA   Bayliss R, Sardon T, Vernos I, Conti E; 
#=GF RL   Mol Cell. 2003;12:851-862.
#=GF DR   INTERPRO; IPR015128;
#=GF CC   The Aurora-A binding domain binds to two distinct sites on the
#=GF CC   Aurora kinase: the upstream residues bind at the N-terminal
#=GF CC   lobe, whilst the downstream residues bind in an alpha-helical
#=GF CC   conformation between the N- and C-terminal lobes. The two
#=GF CC   Aurora-A binding motifs are connected by a flexible linker that
#=GF CC   is variable in length and sequence across species. Binding of
#=GF CC   the domain results strong activation of Aurora-A and protection
#=GF CC   from deactivating dephosphorylation by phosphatase PP1 [1].
#=GF SQ   54
#=GS G3HEA6_CRIGR/1-68      AC G3HEA6.1
#=GS G3SCX4_GORGO/1-33      AC G3SCX4.1
#=GS G1M516_AILME/1-68      AC G1M516.1
#=GS W5MG98_LEPOC/7-71      AC W5MG98.1
#=GS F7HPS3_CALJA/1-67      AC F7HPS3.1
#=GS I3LKS2_PIG/1-68        AC I3LKS2.1
#=GS S9YC07_9CETA/1-68      AC S9YC07.1
#=GS M3VXH7_FELCA/1-68      AC M3VXH7.1
#=GS E2RLT4_CANLF/1-68      AC E2RLT4.2
#=GS G1P8V4_MYOLU/3-60      AC G1P8V4.1
#=GS M7BCD7_CHEMY/1-66      AC M7BCD7.1
#=GS H0VX76_CAVPO/1-52      AC H0VX76.1
#=GS U3JSL1_FICAL/1-63      AC U3JSL1.1
#=GS G1REX2_NOMLE/1-68      AC G1REX2.1
#=GS I3MA66_ICTTR/1-67      AC I3MA66.1
#=GS H2MX82_ORYLA/7-62      AC H2MX82.1
#=GS L9KKR7_TUPCH/3-70      AC L9KKR7.1
#=GS V8N9P3_OPHHA/1-61      AC V8N9P3.1
#=GS H0Z8F1_TAEGU/1-60      AC H0Z8F1.1
#=GS U3ISD9_ANAPL/1-61      AC U3ISD9.1
#=GS TPX2_HUMAN/1-68        AC Q9ULW0.2
#=GS TPX2_HUMAN/1-68        DR PDB; 4C3P B; 6-22;
#=GS TPX2_HUMAN/1-68        DR PDB; 4C3P E; 4-20;
#=GS TPX2_HUMAN/1-68        DR PDB; 3HA6 B; 1-42;
#=GS TPX2_HUMAN/1-68        DR PDB; 3E5A B; 6-42;
#=GS TPX2_HUMAN/1-68        DR PDB; 1OL5 B; 7-43;
#=GS W5NTJ2_SHEEP/1-68      AC W5NTJ2.1
#=GS D3ZA78_RAT/1-68        AC D3ZA78.1
#=GS F6WA27_MONDO/1-67      AC F6WA27.2
#=GS A0A096NV03_PAPAN/1-68  AC A0A096NV03.1
#=GS G3URR4_MELGA/1-64      AC G3URR4.1
#=GS H0VDN1_CAVPO/1-68      AC H0VDN1.1
#=GS G3WJN3_SARHA/1-67      AC G3WJN3.1
#=GS G1SJ85_RABIT/1-68      AC G1SJ85.1
#=GS A0A0N8K1E8_9TELE/6-60  AC A0A0N8K1E8.1
#=GS H2P1K4_PONAB/1-68      AC H2P1K4.2
#=GS F7A3W9_HORSE/1-68      AC F7A3W9.1
#=GS TPX2_MOUSE/1-68        AC A2APB8.1
#=GS L5LM68_MYODS/1-54      AC L5LM68.1
#=GS R4GG69_CHICK/1-61      AC R4GG69.1
#=GS TPX2_BOVIN/1-68        AC A6H6Z7.1
#=GS G1N5U0_MELGA/1-64      AC G1N5U0.2
#=GS F6QQI0_MACMU/1-68      AC F6QQI0.1
#=GS A0A0D9RJZ6_CHLSB/1-68  AC A0A0D9RJZ6.1
#=GS H3ALN4_LATCH/4-61      AC H3ALN4.1
#=GS A0A091DH79_FUKDA/1-68  AC A0A091DH79.1
#=GS H0X6V9_OTOGA/1-68      AC H0X6V9.1
#=GS G3R833_GORGO/1-32      AC G3R833.1
#=GS G3WJN4_SARHA/2-68      AC G3WJN4.1
#=GS L9KH08_TUPCH/1-54      AC L9KH08.1
#=GS TPX2_PONAB/1-68        AC Q5RAF2.1
#=GS F1NW64_CHICK/1-61      AC F1NW64.2
#=GS G3SPN1_LOXAF/1-67      AC G3SPN1.1
#=GS F1MJB6_BOVIN/1-68      AC F1MJB6.2
#=GS G7PGN8_MACFA/1-68      AC G7PGN8.1
#=GS J9NY59_CANLF/1-68      AC J9NY59.1
#=GS TPX2_XENTR/1-57        AC A4IH24.1
#=GS L5K0Q0_PTEAL/1-68      AC L5K0Q0.1
#=GS H2QK54_PANTR/1-68      AC H2QK54.1
G3HEA6_CRIGR/1-68                 ......MSQVTTTYSFDAPTNFINFSSLDAEEDTENVDSWFEEK.ANLGNKLLGKNGIEELFQGKTSLRKAKLQ-k................
G3SCX4_GORGO/1-33                 ......-----------------------------------EEK.ANLENKLLGKNGTGGLFQGKTPLRKANLQQ.................
G1M516_AILME/1-68                 ......MSQVKTSYSYDAPTDFINFTSLDDEEDTQNIDSWFEEK.ANLENKFPAKNGIAGLFQGKTPLRKPNPQQ.................
W5MG98_LEPOC/7-71                 mqqevs----MADYEFDAPSVVIDFKSLDRE---DNADHWFDQI.AEPESKTMDLH-------------------ttpfkakgeaktdvpka
F7HPS3_CALJA/1-67                 ......MSQVRRSYSYDAPSDFINFSSL-DEGDTQNVDSWFEEK.ANLENKLLGKNGTGGLFQGKTPLRKTHLQQ.................
I3LKS2_PIG/1-68                   ......MSHVTTSYSYDAPMDFINFTSLDDEEDTQNIDSWFEEK.ANLENKFPGKNGTGGLFQDKTPLRKANLQQ.................
S9YC07_9CETA/1-68                 ......MSQLTTSYSYDAPTDFINFTSLNDEEDTQNIDSWFEEK.ANLENKFPGKNGTGGLFQGKTPLRKANLHQ.................
M3VXH7_FELCA/1-68                 ......MSQVKTSYSYDAPTDFINFTSLDDEEDTQNIDSWFEEK.ANLENKFPGKNGIGGLFQGKTPLRKPNPQQ.................
E2RLT4_CANLF/1-68                 ......MSQVKTSYSYDAPTDFINFTSLDDEEDAQNIDSWFEEK.ANLENKFSGKNGIAGLFQDKTPLRKPNPQQ.................
G1P8V4_MYOLU/3-60                 ..kvgt-----MSYSYDAPTDFINFTSLDEEEDPQNIDSWFEEK.ANLENRFPDM--------------------tpmrkanppqa......
M7BCD7_CHEMY/1-66                 ......MSHPQSSYSYDAETTYINFRTLNDD-DVQSVDSWFDLK.ASSENVPPAEN-VATFLQHKPASSKANLPQ.................
H0VX76_CAVPO/1-52                 ......--------------NFINFTSLDYEEDTEN-DSWFE-K.ANLENKLLGKNGTGKRFQSKTFVRKANLQQ.................
U3JSL1_FICAL/1-63                 ......MSKPESRYSFDVPNICIDFATLNED-DVHNADSWFDQK.ANLENVPPAENLVSPC---SPAFSKPD---vi...............
G1REX2_NOMLE/1-68                 ......MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEK.ANLENKLLGKNGTGGLFQGKTPLRKANLQQ.................
I3MA66_ICTTR/1-67                 ......MSQVTTTYSFDAPTDFINFTSLDDEEDSENIDSWFDEK.ANLENKYPG-NGTGELFQSKTSVKKGNLQQ.................
H2MX82_ORYLA/7-62                 ..gase------LYEFDAPSHVENFMELVNA---ETDDRWFDER.ASGEDGNLVTPLKPDLMQH-----------kgae.............
L9KKR7_TUPCH/3-70                 ......MSHVKTSYSYDAPMGFINFTSLDDEEDTQNIDSWFEEK.VNLENKFPRKNEIGGLFQGKTPLKKANLQQ.................
V8N9P3_OPHHA/1-61                 .....m---SRETYSYDVPDMCLDFKDMNDD-RSINIDAWFDAR.SAALMTPTAEMGTSGI--------------qpkalpsrsk.......
H0Z8F1_TAEGU/1-60                 ......-----SRYSFDVPNICIDFATLNED-DVHNADSWFDEK.ANLENVPPGEN-LAKVSHFSPASSKPD---vi...............
U3ISD9_ANAPL/1-61                 ......----ESRYSFDVPNPCINFATLSED-DGYNADSWFDQQ.ANLENIPPAEN-RAKILQSSPALSKPD---av...............
TPX2_HUMAN/1-68                   ......MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEK.ANLENKLLGKNGTGGLFQGKTPLRKANLQQ.................
#=GR TPX2_HUMAN/1-68        SS    ......XXXXXX----SS--B---TT--------GGGGGHHHHH.HH---XXXXXXXXXXXXXXXXXXXXXXXXX.................
W5NTJ2_SHEEP/1-68                 ......MSQVTTSYSYDAPTDFINFSSLTDEEDTQHIDSWFDEK.ANLENKFPGKDGTGGLFQGKTPLRKANLHQ.................
D3ZA78_RAT/1-68                   ......MAQVPTAYSFDAPTDFINFSSLDAEEDTENIDSWFDEK.ANLENKFLRQSGIGEPFQGKTSLRKAKLQQ.................
F6WA27_MONDO/1-67                 ......MSQSRASYSFDAPTAFINFTSFNNE-DVCNVDSWFEER.ANLENKPPEDDEVPGPSYRKTPLRKTHVPQ.................
A0A096NV03_PAPAN/1-68             ......MSQVKSSYSYDAPSDFINFSSLDDEGDTQNVDSWFEEK.ANLENKLLGKNGTGGLFQGKTPLRKANLQQ.................
G3URR4_MELGA/1-64                 ......MSRSESRYSFDVPNPCINFATLSDD-DVHNADSWFDQQ.ANLENIPPAEN-LAKVLQNSPAFSKP----li...............
H0VDN1_CAVPO/1-68                 ......MSQVKNSYSFDAPSNFINFTSLDYDEDTENIDSWFEEK.ANLENKFFGKNGTGELFQSKTSLKKANLQQ.................
G3WJN3_SARHA/1-67                 ......MSQSKASYSFDAPTAFFNFTSLNNE-DVYNVDSWFEER.ANLENKPPEDDEAPEPTYRKTPFRKAHVPQ.................
G1SJ85_RABIT/1-68                 ......MSQVQSSYTFDAPTDFINFTSLNDEEDSENVDLWFEEK.ANLENKFPGKNGTGELLHGKTTLRKANLQQ.................
A0A0N8K1E8_9TELE/6-60             ..telp-----DKYEFDAPSHVVDVRSLDLE---DRADQWFDEKvAETRNKQAEK--------------------pravvsprrn.......
H2P1K4_PONAB/1-68                 ......MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEK.ANLENKLLGKSGTGGLFQGKTPLRKANLQQ.................
F7A3W9_HORSE/1-68                 ......MSQVKTSYSYDAPMDFINFTSLDDEEDTQNIDSWFEEK.ANLENKFPGKNGTRGLFQGKTPLRKANPQQ.................
TPX2_MOUSE/1-68                   ......MSQVPTTYSFDAPTDFINFSSLDAEEDTENIDSWFDEK.ANLENKFLRQRGIGEPFQGKNSLRKAKLQQ.................
L5LM68_MYODS/1-54                 .....m------SYSYDAPTDFINFTSLDEEEDPQNIDSWFEEK.ANLENRFPDM--------------------tpmrkanppqa......
R4GG69_CHICK/1-61                 .....m-----SRYSFDVPNPCINFATLSDD-DVHNADSWFDQQ.ANLENIPPAEN-LAKVLQNSPAFSKPA---lv...............
TPX2_BOVIN/1-68                   ......MSQVTTSYSYDAPTDFINFSSLTDEEDMQHIDSWFDEK.ANLENKFTGKDGTGGLYQGKTPLRKANLH-r................
G1N5U0_MELGA/1-64                 ......MSRSESRYSFDVPNPCINFATLSDD-DVHNADSWFDQQ.ANLENIPPAEN-LAKVLQNSPAFSKP----li...............
F6QQI0_MACMU/1-68                 ......MSQVKSSYSYDAPSDFINFSSLDDEGDTQNVDSWFEEK.ANLENKLLGKNGTGGLFQGKTPLRKANLQQ.................
A0A0D9RJZ6_CHLSB/1-68             ......MSQVKSSYSYDAPSDFINFSSLDDEGDTQNVDSWFEEK.ANLENKLLGKNGTGGLFQGKTPLRKANLQQ.................
H3ALN4_LATCH/4-61                 ...dld------TYSFDAPMTF-NFTDLHEQED--DMDSWFEKK.AEVELVPEMDQKDNAL---MTPLKK-----wdpl.............
A0A091DH79_FUKDA/1-68             ......MSQVKNSYSFDAPSDFINFTSLDYEEDTENVDSWFEEK.ANLENKFLGKNGTGELFQNKTSLRKANLQQ.................
H0X6V9_OTOGA/1-68                 ......MSQVQTSYSYDVPKDFIDFTSLDDEGDTENIDSWFEEK.ANLENKLLGKNGTGGPFQSKTPLRKSNLQQ.................
G3R833_GORGO/1-32                 ......------------------------------------EK.ANLENKLLGKNGTGGLFQGKTPLRKANLQQ.................
G3WJN4_SARHA/2-68                 ......MSQSKASYSFDAPTAFFNFTSLNNE-DVYNVDSWFEER.ANLENKPPEDDEAPEPTYRKTPFRKAHVPQ.................
L9KH08_TUPCH/1-54                 ......MSQVKTSYSYDAPMDCINFTSLDDEKDTQNINSWFEEK.ANLEKQNPN---------------------ghqrree..........
TPX2_PONAB/1-68                   ......MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEK.ANLENKLLGKSGTGGLFQGKTPLRKANLQQ.................
F1NW64_CHICK/1-61                 .....m-----SRYSFDVPNPCINFATLSDD-DVHNADSWFDQQ.ANLENIPPAEN-LAKVLQNSPAFSKPA---lv...............
G3SPN1_LOXAF/1-67                 ......MSQV-TSYSFDAPTDYINFTSLNDEENNENVDSWFEEK.ANLENMFPGKNGTGGPFQGKTPLRKGNRQQ.................
F1MJB6_BOVIN/1-68                 ......MSQVTTSYSYDAPTDFINFSSLTDEEDTQHIDSWFDEK.ANLENKFTGKDGTGGLYQGKTPLRKANLH-r................
G7PGN8_MACFA/1-68                 ......MSQVKSSYSYDAPSDFINFSSLDDEGDTQNVDSWFEEK.ANLENKLLGKNGTGGLFQGKTPLRKANLQQ.................
J9NY59_CANLF/1-68                 ......MSQVKTSYSYDAPTDFINFTSLDDEEDAQNIDSWFEEK.ANLENKFSGKNGIAGLFQDKTPLRKPNPQQ.................
TPX2_XENTR/1-57                   ......MAEAQDLYTFDAPSTFINFTAFHED---HGADSWFDKV.TNAENIPPDQRRLSEI--------------pavnae...........
L5K0Q0_PTEAL/1-68                 ......MSQVKASYSYDAPMDFINFTSLNDEEDTQDIDSWFEEK.ANLENKFPGKNGTGALFQDKTPLRKANPQQ.................
H2QK54_PANTR/1-68                 ......MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEK.ANLENKLLGKNGTGGLFQGKTPLRKANLQQ.................
#=GC SS_cons                      ......XXXXXX----SS--B---TT--------GGGGGHHHHH.HH---XXXXXXXXXXXXXXXXXXXXXXXXX.................
#=GC seq_cons                     ......MSQspoSYSaDAPocFINFoSLsDEtDspNlDSWFEEK.ANLENKh.ucNGsutlaQsKTsLRKss.pQ.................
//
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