GenomeNet

Database: Pfam
Entry: Aurora-A_bind
LinkDB: Aurora-A_bind
Original site: Aurora-A_bind 
#=GF ID   Aurora-A_bind
#=GF AC   PF09041.5
#=GF DE   Aurora-A binding 
#=GF AU   Mistry J, Sammut SJ
#=GF SE   pdb_1ol5
#=GF GA   20.20 20.20;
#=GF TC   21.60 23.00;
#=GF NC   19.50 17.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   14580337
#=GF RT   Structural basis of Aurora-A activation by TPX2 at the mitotic
#=GF RT   spindle. 
#=GF RA   Bayliss R, Sardon T, Vernos I, Conti E; 
#=GF RL   Mol Cell. 2003;12:851-862.
#=GF DR   INTERPRO; IPR015128;
#=GF CC   The Aurora-A binding domain binds to two distinct sites on the
#=GF CC   Aurora kinase: the upstream residues bind at the N-terminal
#=GF CC   lobe, whilst the downstream residues bind in an alpha-helical
#=GF CC   conformation between the N- and C-terminal lobes. The two
#=GF CC   Aurora-A binding motifs are connected by a flexible linker that
#=GF CC   is variable in length and sequence across species. Binding of
#=GF CC   the domain results strong activation of Aurora-A and protection
#=GF CC   from deactivating dephosphorylation by phosphatase PP1 [1].
#=GF SQ   51
#=GS Q643R0_HUMAN/1-68  AC Q643R0.1
#=GS G3HEA6_CRIGR/1-68  AC G3HEA6.1
#=GS F1NW64_CHICK/1-65  AC F1NW64.1
#=GS D2H914_AILME/1-68  AC D2H914.1
#=GS F6R2W5_XENTR/1-31  AC F6R2W5.1
#=GS TPX2B_XENLA/1-61   AC Q6DDV8.1
#=GS G3SCX4_GORGO/1-33  AC G3SCX4.1
#=GS G1M516_AILME/1-68  AC G1M516.1
#=GS F7HPS3_CALJA/1-67  AC F7HPS3.1
#=GS TPX2_XENTR/1-61    AC A4IH24.1
#=GS TPX2A_XENLA/1-61   AC Q6NUF4.1
#=GS H0VX76_CAVPO/1-52  AC H0VX76.1
#=GS F6WA27_MONDO/1-67  AC F6WA27.1
#=GS G1REX2_NOMLE/1-68  AC G1REX2.1
#=GS E2RLT4_CANFA/1-68  AC E2RLT4.1
#=GS G7N550_MACMU/1-68  AC G7N550.1
#=GS TPX2_HUMAN/1-68    AC Q9ULW0.2
#=GS TPX2_HUMAN/1-68    DR PDB; 3HA6 B; 1-42;
#=GS TPX2_HUMAN/1-68    DR PDB; 3E5A B; 6-42;
#=GS TPX2_HUMAN/1-68    DR PDB; 1OL5 B; 7-43;
#=GS D3ZA78_RAT/1-68    AC D3ZA78.1
#=GS Q4R8N4_MACFA/1-68  AC Q4R8N4.1
#=GS H0VDN1_CAVPO/1-68  AC H0VDN1.1
#=GS G1N5U0_MELGA/1-66  AC G1N5U0.2
#=GS G3WJN3_SARHA/1-67  AC G3WJN3.1
#=GS G1SJ85_RABIT/1-68  AC G1SJ85.1
#=GS F7A3W9_HORSE/1-68  AC F7A3W9.1
#=GS TPX2_MOUSE/1-68    AC A2APB8.1
#=GS H9Z6J9_MACMU/1-68  AC H9Z6J9.1
#=GS TPX2_BOVIN/1-68    AC A6H6Z7.1
#=GS F6QQI0_MACMU/1-68  AC F6QQI0.1
#=GS H0Z8F1_TAEGU/1-61  AC H0Z8F1.1
#=GS G3R833_GORGO/1-32  AC G3R833.1
#=GS H0X6V9_OTOGA/1-68  AC H0X6V9.1
#=GS F6WA21_MONDO/1-67  AC F6WA21.1
#=GS G3WJN4_SARHA/2-68  AC G3WJN4.1
#=GS TPX2_PONAB/1-68    AC Q5RAF2.1
#=GS Q805A9_CHICK/1-62  AC Q805A9.1
#=GS H2MX82_ORYLA/7-59  AC H2MX82.1
#=GS H2P1K4_PONAB/1-68  AC H2P1K4.1
#=GS H3ALN4_LATCH/3-57  AC H3ALN4.1
#=GS G3SPN1_LOXAF/1-67  AC G3SPN1.1
#=GS G9KUU9_MUSPF/1-68  AC G9KUU9.1
#=GS G1P8V4_MYOLU/3-61  AC G1P8V4.1
#=GS G3URR4_MELGA/1-66  AC G3URR4.1
#=GS F1MJB6_BOVIN/1-68  AC F1MJB6.2
#=GS Q8BTJ3_MOUSE/1-68  AC Q8BTJ3.1
#=GS G7PGN8_MACFA/1-68  AC G7PGN8.1
#=GS E1BA66_BOVIN/1-68  AC E1BA66.1
#=GS Q5ZIC6_CHICK/1-62  AC Q5ZIC6.1
#=GS H2QK54_PANTR/1-68  AC H2QK54.1
#=GS G1REX1_NOMLE/1-68  AC G1REX1.1
#=GS Q96RR5_HUMAN/1-68  AC Q96RR5.1
#=GS B5X2W1_SALSA/5-62  AC B5X2W1.1
Q643R0_HUMAN/1-68             ......MSQVKSSYSYDAPSDFINFSSLDDEgDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQ.................
G3HEA6_CRIGR/1-68             ......MSQVTTTYSFDAPTNFINFSSLDAEeDTENVDSWFEEKANLGNKLLGKNGIEELFQGKTSLRKAKLQK.................
F1NW64_CHICK/1-65             ..svkm-----SRYSFDVPNPCINFATLSDD.DVHNADSWFDQQANLENIPPAEN-LAKVLQNSPAFSKPAL--vl...............
D2H914_AILME/1-68             ......MSQVKTSYSYDAPTDFINFTSLDDEeDTQNIDSWFEEKANLENKFPAKNGIAGLFQGKTPLRKPNPQQ.................
F6R2W5_XENTR/1-31             ......-------------------------.-------WADKVTNAENIPPDQRQLSEIPAVNAE--------qngm.............
TPX2B_XENLA/1-61              ......MADAQDTYSYDAPSIF-NFSSFHDD.--HNADSWFDQLTNAENIPPDQKPLSET-SVNAE--------qnckve...........
G3SCX4_GORGO/1-33             ......-------------------------.---------EEKANLENKLLGKNGTGGLFQGKTPLRKANLQQ.................
G1M516_AILME/1-68             ......MSQVKTSYSYDAPTDFINFTSLDDEeDTQNIDSWFEEKANLENKFPAKNGIAGLFQGKTPLRKPNPQQ.................
F7HPS3_CALJA/1-67             ......MSQVRRSYSYDAPSDFINFSSLDEG.DTQNVDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKTHLQQ.................
TPX2_XENTR/1-61               ......MAEAQDLYTFDAPSTFINFTAFHED.--HGADSWFDKVTNAENIPPDQRRLSEIPAVNAE--------qngm.............
TPX2A_XENLA/1-61              ......MEDTQDTYSYDAPSIF-NFSSFHED.--HNADSWFDQVTNAENIPPDQRRLSET-SVNTE--------qnskve...........
H0VX76_CAVPO/1-52             ......--------------NFINFTSLDYEeDTEN-DSWFE-KANLENKLLGKNGTGKRFQSKTFVRKANLQQ.................
F6WA27_MONDO/1-67             ......MSQSRASYSFDAPTAFINFTSFNNE.DVCNVDSWFEERANLENKPPEDDEVPGPSYRKTPLRKTHV--pq...............
G1REX2_NOMLE/1-68             ......MSQVKSSYSYDAPSDFINFSSLDDEgDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQ.................
E2RLT4_CANFA/1-68             ......MSQVKTSYSYDAPTDFINFTSLDDEeDAQNIDSWFEEKANLENKFSGKNGIAGLFQDKTPLRKPNPQQ.................
G7N550_MACMU/1-68             ......MSQVKSSYSYDAPSDFINFSSLDDEgDTQNVDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQ.................
TPX2_HUMAN/1-68               ......MSQVKSSYSYDAPSDFINFSSLDDEgDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQ.................
#=GR TPX2_HUMAN/1-68    SS    ......XXXXXX----SS--B---TT--XXXXXXGGGGGHHHHHHH---XXXXXXXXXXXXXXXXXXXXXXXXX.................
D3ZA78_RAT/1-68               ......MAQVPTAYSFDAPTDFINFSSLDAEeDTENIDSWFDEKANLENKFLRQSGIGEPFQGKTSLRKAKLQQ.................
Q4R8N4_MACFA/1-68             ......MSQVKSSYSYDAPSDFINFSSLDDEgDTQNVDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQ.................
H0VDN1_CAVPO/1-68             ......MSQVKNSYSFDAPSNFINFTSLDYDeDTENIDSWFEEKANLENKFFGKNGTGELFQSKTSLKKANLQQ.................
G1N5U0_MELGA/1-66             ......MSRSESRYSFDVPNPCINFATLSDD.DVHNADSWFDQQANLENIPPAEN-LAKVLQNSPAFSKPL---ils..............
G3WJN3_SARHA/1-67             ......MSQSKASYSFDAPTAFFNFTSLNNE.DVYNVDSWFEERANLENKPPEDDEAPEPTYRKTPFRKAHV--pq...............
G1SJ85_RABIT/1-68             ......MSQVQSSYTFDAPTDFINFTSLNDEeDSENVDLWFEEKANLENKFPGKNGTGELLHGKTTLRKANLQQ.................
F7A3W9_HORSE/1-68             ......MSQVKTSYSYDAPMDFINFTSLDDEeDTQNIDSWFEEKANLENKFPGKNGTRGLFQGKTPLRKANPQQ.................
TPX2_MOUSE/1-68               ......MSQVPTTYSFDAPTDFINFSSLDAEeDTENIDSWFDEKANLENKFLRQRGIGEPFQGKNSLRKAKLQQ.................
H9Z6J9_MACMU/1-68             ......MSQVKSSYSYDAPSDFINFSSLDDEgDTQNVDSWFEEKANLENKLLGKNGTGGLFQGRTPLRKANLQQ.................
TPX2_BOVIN/1-68               ......MSQVTTSYSYDAPTDFINFSSLTDEeDMQHIDSWFDEKANLENKFTGKDGTGGLYQGKTPLRKANLHR.................
F6QQI0_MACMU/1-68             ......MSQVKSSYSYDAPSDFINFSSLDDEgDTQNVDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQ.................
H0Z8F1_TAEGU/1-61             .....s------RYSFDVPNICIDFATLNED.DVHNADSWFDEKANLENVPPGEN-LAKVSHFSPASSKPDV--il...............
G3R833_GORGO/1-32             ......-------------------------.----------EKANLENKLLGKNGTGGLFQGKTPLRKANLQQ.................
H0X6V9_OTOGA/1-68             ......MSQVQTSYSYDVPKDFIDFTSLDDEgDTENIDSWFEEKANLENKLLGKNGTGGPFQSKTPLRKSNLQQ.................
F6WA21_MONDO/1-67             ......MSQSRASYSFDAPTAFINFTSFNNE.DVCNVDSWFEERANLENKPPEDDEVPGPSYRKTPLRKTHV--pq...............
G3WJN4_SARHA/2-68             ......MSQSKASYSFDAPTAFFNFTSLNNE.DVYNVDSWFEERANLENKPPEDDEAPEPTYRKTPFRKAHV--pq...............
TPX2_PONAB/1-68               ......MSQVKSSYSYDAPSDFINFSSLDDEgDTQNIDSWFEEKANLENKLLGKSGTGGLFQGKTPLRKANLQQ.................
Q805A9_CHICK/1-62             .....m-----SRYSFDVPNPCINFATLSDD.DVHNADSWFDQQANLENIPPAEN-LAKVLQNSPAFSKPALI-l................
H2MX82_ORYLA/7-59             ....ga----SELYEFDAPSHVENFMELVNA.--ETDDRWFDERASGED-------------------------gnlvtplkpdlmqhk..
H2P1K4_PONAB/1-68             ......MSQVKSSYSYDAPSDFINFSSLDDEgDTQNIDSWFEEKANLENKLLGKSGTGGLFQGKTPLRKANLQQ.................
H3ALN4_LATCH/3-57             ...mdl-----DTYSFDAPMTF-NFTDLHEQ.-EDDMDSWFEKKAEVELVPEMD--------------------qkdnalmtplkk.....
G3SPN1_LOXAF/1-67             ......MSQ-VTSYSFDAPTDYINFTSLNDEeNNENVDSWFEEKANLENMFPGKNGTGGPFQGKTPLRKGNRQQ.................
G9KUU9_MUSPF/1-68             ......MSQVKTSYSYDAPTDFINFTSLNDEeDTQNIDSWFEEKANLENKFPGKNGIAGLFQGKTPLRKPNPQQ.................
G1P8V4_MYOLU/3-61             ..kvgt-----MSYSYDAPTDFINFTSLDEEeDPQNIDSWFEEKANLENRFPDMT-------------------pmrkanppqai......
G3URR4_MELGA/1-66             ......MSRSESRYSFDVPNPCINFATLSDD.DVHNADSWFDQQANLENIPPAEN-LAKVLQNSPAFSKPL---ils..............
F1MJB6_BOVIN/1-68             ......MSQVTTSYSYDAPTDFINFSSLTDEeDTQHIDSWFDEKANLENKFTGKDGTGGLYQGKTPLRKANLHR.................
Q8BTJ3_MOUSE/1-68             ......MSQVPTTYSFDAPTDFINFSSLDAEeDTENIDSWFDEKANLENKFLRQRGIGEPFQGKNSLRKAKLQQ.................
G7PGN8_MACFA/1-68             ......MSQVKSSYSYDAPSDFINFSSLDDEgDTQNVDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQ.................
E1BA66_BOVIN/1-68             ......MSQVTTSYSYDAPTDFINFSSLTDEeDTQHIDSWFDEKANLENKFTGKDGTGGLYQGKTPLRKANLHR.................
Q5ZIC6_CHICK/1-62             .....m-----SRYSFDVPNPCINFATLSDD.DVHNADSWFDQQANLENIPPAEN-LAKVLQNSPAFSKPAL--vl...............
H2QK54_PANTR/1-68             ......MSQVKSSYSYDAPSDFINFSSLDDEgDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQ.................
G1REX1_NOMLE/1-68             ......MSQVKSSYSYDAPSDFINFSSLDDEgDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQ.................
Q96RR5_HUMAN/1-68             ......MSQVKSSYSYDAPSDFINFSSLDDEgDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQ.................
B5X2W1_SALSA/5-62             maqges----ASHYEFDAPSHVIDFQALDTE.--DNADIWFDQCAGQD--------------------------erlfghlatpnrnnipf
#=GC SS_cons                  ......XXXXXX----SS--B---TT--XXXXXXGGGGGHHHHHHH---XXXXXXXXXXXXXXXXXXXXXXXXX.................
#=GC seq_cons                 ......MSQspoSYSaDAPocFINFoSLc-EtDspNlDSWFEEKANLENKh.ucNGhutlaQuKTsLRKsslpp.................
//
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