GenomeNet

Database: Pfam
Entry: AviRa
LinkDB: AviRa
Original site: AviRa 
#=GF ID   AviRa
#=GF AC   PF11599.6
#=GF DE   RRNA methyltransferase AviRa
#=GF AU   Pollington J
#=GF SE   pdb_1o9g
#=GF GA   26.10 26.10;
#=GF TC   26.50 59.80;
#=GF NC   21.00 20.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12742024
#=GF RT   Crystal structure of the avilamycin resistance-conferring
#=GF RT   methyltransferase AviRa from Streptomyces viridochromogenes. 
#=GF RA   Mosbacher TG, Bechthold A, Schulz GE; 
#=GF RL   J Mol Biol. 2003;329:147-157.
#=GF DR   INTERPRO; IPR024268;
#=GF CC   This family of proteins represents the methyltransferase AviRa
#=GF CC   from Streptomyces viridochromogenes. This protein mediates the
#=GF CC   resistance to the antibiotic avilamycin. AviRa methylates a
#=GF CC   specific guanine base within the peptidyl-transferase loop of
#=GF CC   the 23S ribosomal RNA [1].
#=GF SQ   12
#=GS A0A0M8XW25_9ACTN/1-225  AC A0A0M8XW25.1
#=GS D7AX50_NOCDD/1-241      AC D7AX50.1
#=GS G4L5U2_TETHN/1-242      AC G4L5U2.1
#=GS J7LF16_NOCAA/1-238      AC J7LF16.1
#=GS G4HLL5_9BACL/1-243      AC G4HLL5.1
#=GS A0A060LXB2_9BACI/1-240  AC A0A060LXB2.1
#=GS A0A0N1NBN1_9ACTN/1-254  AC A0A0N1NBN1.1
#=GS D2AWL7_STRRD/1-239      AC D2AWL7.1
#=GS A9KJB4_CLOPH/1-237      AC A9KJB4.1
#=GS D1BGB8_SANKS/1-209      AC D1BGB8.1
#=GS L0EEW0_THECK/1-247      AC L0EEW0.1
#=GS D3EHE3_GEOS4/1-244      AC D3EHE3.1
A0A0M8XW25_9ACTN/1-225             .......m-----.--.-.------ASGNVLRSAPGFPGFPVRLASELFQRGLAH-VPR.E......P...VRMWDPCCGSGYLVTVLGLLHRDRIVHARATDVDPDAVALAARNLALLTREGLAEREEELRRSALDFGRAEFVGRAETAGALAAGL...A...S...M.G.....GDL........PHETGVA.....D....V..FTLseP..V.EA.D..LVVTDVPYGDLTHWR.G..E.A..P.GddpMA...ALLASLGR....VL.P.PHAVIVVTARTRRVVLPPGVRALERVKVGNRA------------avlvrardv..................
D7AX50_NOCDD/1-241                 ........MGYRY.AV.ErTDHSALAGGHVLRSAPGFPGFPVRLASELFQRAMVHTG-G.E......P...VRLWDPCCGSGYLATVLGLLHRDLLTGVRATDVDADAVALAARNLRLLTAEGLAEREEELRRSARDFGRVAFVERAEAARDLAAGL...A...A...Q.G.....GDL........PHEAAVA.....D....V..FSL..EegV.EA.D..LVVTDVPYGEMTRWE.G..NvP..G.G...AG...EPMRGLLAslgrVL.P.EHAVVVVTARTRRVSLPEGVRALERVKVGNRA------------avlvrardi..................
G4L5U2_TETHN/1-242                 mkfkfepi-----.--.K.KDYSDFSSDKLLVNAPRTPAFPVRVASEIMARSLSFLNSA.D......G...LTLYDPCCGGGHLLTVLGFCYSKNLKNIYGSDIDTKALEYAQKNLNLLTPEGLSKKKKDLQYNDEKQDEKTQLEALNSANRLEKQLfhtTypkK...D.I.....QC-........-FHWDIT.....R....KkpPHL..-..K.NV.N..IVITDLPYGKMSDWQgE..G.T..T.Q...NNpnkQMLNNIYQ....TLdL.NNSIVTIICNKQEKINHQKFEQVKRLKHGKRQFI----------flrp.......................
J7LF16_NOCAA/1-238                 ........MSYRYaTE.R.ADHSALASGQVLRSAPGYPGFPVRLADELLQRAMV-HVEG.D......R...VRLWDPCCGSGYLVTVLGLLHRDLLTHVRASDVSSDAVGIAARNLELLTAEGLAERERELRRSARDFGRVAFVERAEAARDLAAGL...A...A...M.G.....GDL........PHESAVA.....D....V..FSLteP..V.DA.D..LVITDVPYGEMTHWD.G..E.ApeD.P...VR...GLLASMGR....VL.P.RNSVVVVTARTRRVRLPEGVRALERVKVGNRS------------avllrardl..................
G4HLL5_9BACL/1-243                 ........MEYLY.ES.ApRSFEDFASGRVLYNARGTTSFPVRLASELAQRCFHLLEQKgA......Eg.pYTLYDPCCGGAYLLTVVGMLHGRRLGRIIGSDIQPDVLPIAGKNLSLLRKEGLEQRAEQIKSLYEQYGKPSHRDALESATRLKELI...A...E...SaI....eEAA........CFQSDIT.....Dp.kgG..LDR..A..R.GT.H..IVMTDLPYGDLVSWG.G..G.S..E.D..pVG...RFFEQIHP....IL.DpARSVVAVISDKGQKLKHDRFRRLQHMKIGKRQAAIF--------epl........................
A0A060LXB2_9BACI/1-240             ..mqftye-----.TI.K.RDFSDFSSGRVLYNAPGSTGFPIRLTSEIFQISRSYLQKP.S......Q...LNVYDPCCGGAHLLTGIGFLHGGSIQTLYGSDSNETIIETGQSNLRLLTYEGLAQRKRKLEKDYLLFNKSAHAEALKSVDRLKSYLd.kT...G...E.V.....KGE........IFQFNIA.....-....S..KDV..P..K.LE.EihIVMTDLPYGELVSWD.T..N.V.lS.P...VK...QMLQNVYS....VL.A.HDGVVAVVSDKFTLIEHPLFRRLKVLKHGKRKVTLL--------qaidhe.....................
A0A0N1NBN1_9ACTN/1-254             ..mpyrha-----.TE.R.SDGSDFASGFVLHSAPNHPAFPVRLATELFLRALEHLPTP.TgpgsgpG...VTLWDPCCGSGHLATVLGWCHRRTIGRVVASDVDGETLSLARKNLRLLSPEGLLDRERERLELSVRFDKPAYAEAARAAHRLAGRL...A...E...D.G.....GALpwsagradVFDPASL.....SallaS..AGL.rG..A.AP.D..VVVMDVPYGERTHWG.G..Q.ApeR.P...VP...ALLRSLAA....VL.P.PHAVIAVA-DRARKIPVAPLRPLERLRIGTRS------------avlvraad...................
D2AWL7_STRRD/1-239                 ...myrha-----.TV.R.GDYEDLASGAVLHSAPGFPAFPVRLASEAFQRALALRGGG.G......P...ATVWDPCCGSGYLLTVIGLLHRGRIQALLASDVSDDALRLARANLDLLGQAGLSARAGVLREKAERFAKPSYAAAAEAAGRIGRML...A...AgggD.VphdvrRAD........VFDPGQL.....A....E..AAA..G..Y.AP.D..IVVTDVPYGEQTTWQ.GpgG.D..S.G...VP...GMLAALAP....VL.T.ERAVVVVTA-----------------------------------rgrkvplggriraresfkvgtravall
A9KJB4_CLOPH/1-237                 ........MEYKY.TK.N.DNYEDFASGRVLYHVGGEPTFPVRLALEIYERCLQYSIKK.A......E...ISLYDCCCGGAYMLSILGLLKSNTIANLYGSDINSESIQLANDNLGLLTKSGINKRRDELKALYQTYKKASHIDALHSIDRIEELL...T...R...E.I.....KTY........LFKGNVL.....E....V..CDL..P..F.TP.D..IIITDVPYGNMVEWE.E..G.S..G.G...IN...QMMNALSA....VC.G.SDTIICVCMDKKQKIHNDIFQRLERQLVGKRKFEIYKKKASEIA...........................
D1BGB8_SANKS/1-209                 ........MKFEH.AP.Q.ASYEDVGGGQVLHSAPGFPGFPARLAVELFERAR-VLVGR.E......R...VGLWDPMCGAGGILTSVALLRPDALTRVLASDVDEGALELARKNLLLTTVPGLEARRAELVERGAAAGRVASADRL--LARVAGLP...A...P...P.-.....-AS........LARADVT.....Dp.ssV..AGL..D..LdGV.D..VVMADLPYGTQTDWA.S..T.S..T.T..pTA...QALE----....--.-.--------------------------------------------vlrdalpdgavvvlstterehlr....
L0EEW0_THECK/1-247                 ........MEYRF.AT.D.EPRGHFASGRVLYNAKGAAPFPVRLADEIVQRCFHYLEER.G......HsgpYAIYDPCCGSGYLLTVIGLLHGAQIRAVFASDIDESMLETARRNLSLLTAEGMRARIEQLRELYEQYGKPSHAEALESAAMLDGYRacgT...V...EsI.....EMFp.....adITVGSPE.....A....V..RDS..G..F.CPvN..IVIADLPYGHLTGWQ.S..G.S..A.D..pAA...RMLDSLFP....LLrP.GASVIALISDKSHKLRHERYRRIALLKAGKRQIALFEPK-----gc.........................
D3EHE3_GEOS4/1-244                 ........MEYIY.ESaQ.RSYEDFASGRVLYNAQGTTSFPVRLASEIAQRCFHILEEK.Gv...qgP...YTLYDPCCGGAYLLTVVGLLHGRRIRRVIGSDINAEVLGIAGKNLSLLREEGLEQRTEQLKELLALYHKPSHQDALESADRLRELIr.mS...R...L.E.....ETF........CFQADITqpqpeE....S..LAS..C..K.GT.Q..IVMTDLPYGDMVSWS.G..G.S..QeP...VE...DFFNGIHA....IL.DpVRSVVAVISDKGQKLKHDRFKRIQHLKIGKRQVAIF--------ep.........................
#=GC seq_cons                      ..............s..p.psapDhASGpVLasAPGhPuFPVRLAoElhQRuhthh.pt.s......t...lsLaDPCCGuGYLLTVlGLLHtcplpplhuSDlss-sltlAt+NLpLLTtEGLtpRcccL+c.htpas+suas-AhcuAsRLtthL...u...t...p.h.....tsh........hacssls.....c....s..hsl..s..h.ss.-..lVlTDlPYG-hopWp.u..s.u..s.s...ss...phLpulhs....lL.s.tcuVlsVhucptphl..thh+tlp+lKhGpRp............tsh........................
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