GenomeNet

Database: Pfam
Entry: AviRa
LinkDB: AviRa
Original site: AviRa 
#=GF ID   AviRa
#=GF AC   PF11599.3
#=GF DE   RRNA methyltransferase AviRa
#=GF AU   Pollington J
#=GF SE   pdb_1o9g
#=GF GA   26.10 26.10;
#=GF TC   26.60 132.50;
#=GF NC   24.60 26.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12742024
#=GF RT   Crystal structure of the avilamycin resistance-conferring
#=GF RT   methyltransferase AviRa from Streptomyces viridochromogenes. 
#=GF RA   Mosbacher TG, Bechthold A, Schulz GE; 
#=GF RL   J Mol Biol. 2003;329:147-157.
#=GF DR   INTERPRO; IPR024268;
#=GF CC   This family of proteins represents the methyltransferase AviRa
#=GF CC   from Streptomyces viridochromogenes. This protein mediates the
#=GF CC   resistance to the antibiotic avilamycin. AviRa methylates a
#=GF CC   specific guanine base within the peptidyl-transferase loop of
#=GF CC   the 23S ribosomal RNA [1].
#=GF SQ   11
#=GS D2AWL7_STRRD/1-245  AC D2AWL7.1
#=GS G4HLL5_9BACL/1-243  AC G4HLL5.1
#=GS F3MGB2_9BACL/1-244  AC F3MGB2.1
#=GS G4L5U2_TETHN/1-243  AC G4L5U2.1
#=GS Q9F5K5_STRVR/1-246  AC Q9F5K5.2
#=GS Q9F5K5_STRVR/1-246  DR PDB; 1O9H A; 2-246;
#=GS Q9F5K5_STRVR/1-246  DR PDB; 1O9G A; 2-246;
#=GS C4RPB1_9ACTO/1-246  AC C4RPB1.1
#=GS A9KJB4_CLOPH/1-237  AC A9KJB4.1
#=GS D1BGB8_SANKS/1-232  AC D1BGB8.1
#=GS G4EG21_9BACL/1-246  AC G4EG21.1
#=GS D7AX50_NOCDD/1-242  AC D7AX50.1
#=GS D3EHE3_GEOS4/1-244  AC D3EHE3.1
D2AWL7_STRRD/1-245             ..m---YRHATVRGDYEDLASGAVLHSAPGFPAFPVRLASEAFQRALALRGG...G...GPATVWDPCCGSGYLLTVIGLLHRGRIQALLASDVSDDALRLARANLDLLGQAGLSARAGVLREKAERFAKPSYAAAAEAAGRIGRMLAAGGGDVP.HDVRRADVFDPGQLAEA.AAGYAP.DIVVTDVPYGEQTTWQGP..GGDS...GVPGMLAALAPVL.T.ERAVVVV.TARGRKVP.LgGRIRARESFKVGTRAVALL..TAD---qlg.
G4HLL5_9BACL/1-243             ...ME-YLYESAPRSFEDFASGRVLYNARGTTSFPVRLASELAQRCFHLLEQkgaE...GPYTLYDPCCGGAYLLTVVGMLHGRRLGRIIGSDIQPDVLPIAGKNLSLLRKEGLEQRAEQIKSLYEQYGKPSHRDALESATRLKELIAES-AIEE.AACFQSDITDPKG--GL.DRARGT.HIVMTDLPYGDLVSWGG-..GSED...PVGRFFEQIHPILdP.ARSVVAViSDKGQKLK.H.DRFRRLQHMKIGKRQAAIF..------epl.
F3MGB2_9BACL/1-244             ...ME-YIYESAQRSYEDFASGRVLYNAQGTTSFPVRLASEIAQRCFQILEE...KgvqGPYTLYDPCCGGAYLLTVVGLLHGRRIRRMIGSDINAEVLGIAGKNLSLLREEGLKQRTEQLKELLALYHKPSHQDALESADRLRELIRMSRLEET.ICFQT-DITQPQPEESL.ASCTGT.QIVMTDLPYGDMVSWSG-..GSQA...PVEDFFNGIHAILdP.AGSVVAViSDKGQKLK.H.DRFKRIQQLKIGKRQVAIF..------ep..
G4L5U2_TETHN/1-243             .mk---FKFEPIKKDYSDFSSDKLLVNAPRTPAFPVRVASEIMARSLSFLNS...A...DGLTLYDPCCGGGHLLTVLGFCYSKNLKNIYGSDIDTKALEYAQKNLNLLTPEGLSKKKKDLQYNDEKQDEKTQLEALNSANRLEKQLFHT--TYPkKDIQC---FHWDITRKKpPHLKNV.NIVITDLPYGKMSDWQGEgtTQNN...PNKQMLNNIYQTL.DlNNSIVTIiCNKQEKIN.H.QKFEQVKRLKHGKRQFIFL..R-----pl..
Q9F5K5_STRVR/1-246             ...MSAYRHAVERIDSSDLACGVVLHSAPGYPAFPVRLATEIFQRALARLPG...D...GPVTLWDPCCGSGYLLTVLGLLHRRSLRQVIASDVDPAPLELAAKNLALLSPAGLTARELERREQSERFGKPSYLEAAQAARRLRERLTAEGGALP.CAIRTADVFDPRALSAV.LAGSAP.DVVLTDLPYGERTHWEGQ..VPAQ...PVAGLLRSLASAL.P.AHAVIAV.TDRSRKIP.V.APVKALERLKIGTRSAVLV..RAADVL....
#=GR Q9F5K5_STRVR/1-246  SS    ...X---SSS-S----CCCSTTTSS--BTTB----HHHHHHHHHHHHCTSSS...-...S-EEEEETT-TTSHHHHHHHHHTGGGEEEEEEEES-HHHHHHHHHHHHCCSHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHTTSS--.EEEEE--TT-HHHHHHH.HTT---.SEEEEE--CCCSSSTTS-..--HH...HHHHHHHHHHCCS.-.TT-EEEE.EESSSS--.-.TTS--SEEEEETTEEEEEE..EHHHHH....
C4RPB1_9ACTO/1-246             ..m-T-YRHETVRGAYGDLASGAVLRSAPGFPAFPVRLASEVLQTALELRPT...S...APATVWDPCCGSGYLLTVLALLHRPSLAGLLASDVDEAALDLARANLGLLTGAGLDTRARELAQRAEAFDKPHYAEAAAAAHRLRARLDAAGGPLP.YAVRRADVFDRVALTEA.VAGMTP.DLVVTDLPYGEQTSWQGE..RAGE...GLPGMLTRVASVL.P.PTGVLAV.VLRGRKVPpV.GEVRPRRRLRVGTRAAAFF..VAGD--lt..
A9KJB4_CLOPH/1-237             ...ME-YKY-TKNDNYEDFASGRVLYHVGGEPTFPVRLALEIYERCLQYSIK...K...AEISLYDCCCGGAYMLSILGLLKSNTIANLYGSDINSESIQLANDNLGLLTKSGINKRRDELKALYQTYKKASHIDALHSIDRIEELLTRE-----.--IKTY-LFKGNVLEVC.DLPFTP.DIIITDVPYGNMVEWEE-..-GSG...GINQMMNALSAVC.G.SDTIICVcMDKKQKIH.N.DIFQRLERQLVGKRKFEIYkkKASEIA....
D1BGB8_SANKS/1-232             mkf----EH-APQASYEDVGGGQVLHSAPGFPGFPARLAVELFERA-RVLVG...R...ERVGLWDPMCGAGGILTSVALLRPDALTRVLASDVDEGALELARKNLLLTTVPGLEARRAELVERGAAAGR------VASADRLLARVAGL-PAPP.ASLARADVTDPSSVAGL.DLDG-V.DVVMADLPYGTQTDWAS-..TSTT...PTAQALEVLRDAL.P.DGAVVVL.STTEREHL.R.GLPDATRSFKHGHRYVRLY..R-----tga.
G4EG21_9BACL/1-246             ...ME-YRFATDE-PRGHFASGRVLYNAKGAAPFPVRLADEIVQRCFHYLEErghS...GPYAIYDPCCGSGYLLTVIGLLHGAQIRAVFASDIDESMLETARRNLSLLTAEGMRARIEQLRELYEQYGKPSHAEALESAAMLDGY-RACGTVES.IEMFPADITVGSPEAVR.DSGFCPvNIVIADLPYGHLTGWQS-..GSAD...PAARMLDSLFPLLrP.GASVIALiSDKSHKLR.H.ERYRRIALLKAGKRQIALF..------epkg
D7AX50_NOCDD/1-242             ..m-G-YRYAVERTDHSALAGGHVLRSAPGFPGFPVRLASELFQRAMVHT-G...G...EPVRLWDPCCGSGYLATVLGLLHRDLLTGVRATDVDADAVALAARNLRLLTAEGLAEREEELRRSARDFGRVAFVERAEAARDLAAGLAAQGGDLP.HEAAVADVFS------L.EEGVEA.DLVVTDVPYGEMTRWEGN..VPGGagePMRGLLASLGRVL.P.EHAVVVV.TARTRRVS.LpEGVRALERVKVGNRAAVLV..RARDIA....
D3EHE3_GEOS4/1-244             ...ME-YIYESAQRSYEDFASGRVLYNAQGTTSFPVRLASEIAQRCFHILEE...KgvqGPYTLYDPCCGGAYLLTVVGLLHGRRIRRVIGSDINAEVLGIAGKNLSLLREEGLEQRTEQLKELLALYHKPSHQDALESADRLRELIRMS-RLEE.TFCFQADITQPQPEESL.ASCKGT.QIVMTDLPYGDMVSWSG-..GSQE...PVEDFFNGIHAILdP.VRSVVAViSDKGQKLK.H.DRFKRIQHLKIGKRQVAIF..------ep..
#=GC SS_cons                   ...X---SSS-S----CCCSTTTSS--BTTB----HHHHHHHHHHHHCTSSS...-...S-EEEEETT-TTSHHHHHHHHHTGGGEEEEEEEES-HHHHHHHHHHHHCCSHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHHHTTSS--.EEEEE--TT-HHHHHHH.HTT---.SEEEEE--CCCSSSTTS-..--HH...HHHHHHHHHHCCS.-.TT-EEEE.EESSSS--.-.TTS--SEEEEETTEEEEEE..EHHHHH....
#=GC seq_cons                  ....p.Y+atosptsYpDhASG+VLasAsGhPuFPVRLASElhQRshphL.p...p...uPhTLaDPCCGuGYLLTVlGLLHscplpplluSDlsscsLplAt+NLuLLotpGLppRpcpL+chhcpasKPSah-AlcSAcRLcchlsts.ss.s.tshtpADlhcsps.tsh.stshss.cIVlTDLPYG-hosWpG...suss...PlsphLsultslL.P.spuVVsV.os+ucKlp.p.sch+tlc+lKlG+Rpssla..h.........
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