GenomeNet

Database: Pfam
Entry: AviRa
LinkDB: AviRa
Original site: AviRa 
#=GF ID   AviRa
#=GF AC   PF11599.7
#=GF DE   RRNA methyltransferase AviRa
#=GF AU   Pollington J
#=GF SE   pdb_1o9g
#=GF GA   26.10 26.10;
#=GF TC   26.20 44.80;
#=GF NC   21.00 25.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12742024
#=GF RT   Crystal structure of the avilamycin resistance-conferring
#=GF RT   methyltransferase AviRa from Streptomyces viridochromogenes. 
#=GF RA   Mosbacher TG, Bechthold A, Schulz GE; 
#=GF RL   J Mol Biol. 2003;329:147-157.
#=GF DR   INTERPRO; IPR024268;
#=GF CC   This family of proteins represents the methyltransferase AviRa
#=GF CC   from Streptomyces viridochromogenes. This protein mediates the
#=GF CC   resistance to the antibiotic avilamycin. AviRa methylates a
#=GF CC   specific guanine base within the peptidyl-transferase loop of
#=GF CC   the 23S ribosomal RNA [1].
#=GF SQ   24
#=GS A0A094JRL9_9BACL/1-240  AC A0A094JRL9.1
#=GS D7AX50_NOCDD/1-241      AC D7AX50.1
#=GS J7LF16_NOCAA/1-238      AC J7LF16.1
#=GS A0A0J1DJF7_9FIRM/1-242  AC A0A0J1DJF7.1
#=GS A0A060LXB2_9BACI/1-240  AC A0A060LXB2.1
#=GS A0A0C2G8J6_9ACTN/1-241  AC A0A0C2G8J6.1
#=GS A0A091CDM9_9ENTE/1-242  AC A0A091CDM9.1
#=GS A0A061P0B3_9BACL/7-244  AC A0A061P0B3.1
#=GS A0A136PPG4_9ACTN/1-216  AC A0A136PPG4.1
#=GS L0EEW0_THECK/1-247      AC L0EEW0.1
#=GS D1BGB8_SANKS/1-209      AC D1BGB8.1
#=GS A0A0N7JZF6_9PSEU/1-181  AC A0A0N7JZF6.1
#=GS A0A061PHI3_9BACL/1-238  AC A0A061PHI3.1
#=GS D3EHE3_GEOS4/1-244      AC D3EHE3.1
#=GS A0A0M8XW25_9ACTN/1-225  AC A0A0M8XW25.1
#=GS G4L5U2_TETHN/1-242      AC G4L5U2.1
#=GS A0A0M4QLW8_9PSEU/1-185  AC A0A0M4QLW8.1
#=GS M3CC20_STRMB/3-244      AC M3CC20.1
#=GS R9KC37_9FIRM/1-97       AC R9KC37.1
#=GS A0A0N1NBN1_9ACTN/1-254  AC A0A0N1NBN1.1
#=GS D2AWL7_STRRD/1-239      AC D2AWL7.1
#=GS V9GBS0_9BACL/1-251      AC V9GBS0.1
#=GS A9KJB4_CLOPH/1-237      AC A9KJB4.1
#=GS R9KK57_9FIRM/2-99       AC R9KK57.1
A0A094JRL9_9BACL/1-240             ....................MKYHY.EiE.K.KDYRDFASGRVLYNVPGSAPFPVRLASEIFYRAQSFlNEE...KN......G...FKLYDPCCGSGYLLTVLGFLHASKIREIAASDDDEKMVAFARKNLSLLSFAGLRRREEEIRKYVKEYG.KPSHIEALDSVQVLKAYL...K........K...E......pI.....QIT........CFQRD...IT.....K....P..DE.N..P....V.Q..rV.Q..VIITDLPYGNLVSWR..G..N.D..eN.P...VQ...SLFENLwKA....MD.L.NNSVAVIITGQKIKPEHEGFNRVHHFKVGKRHVSFFKP------vss........................
D7AX50_NOCDD/1-241                 ....................MGYRY.A.V.ErTDHSALAGGHVLRSAPGFPGFPVRLASELFQRAMVH.TG-...GE......P...VRLWDPCCGSGYLATVLGLLHRDLLTGVRATDVDADAVALAARNLRLLTAEGLAEREEELRRSARDFG.RVAFVERAEAARDLAAGL...A........A...Q.......G.....GDL........PHEAA...VA.....D....V..FS.L..Ee..gV.E...A.D..LVVTDVPYGEMTRWE..G..NvP...G.G...AG...EPMRGL.LAslgrVL.P.EHAVVVVTARTRRVSLPEGVRALERVKVGNRA------------avlvrardi..................
J7LF16_NOCAA/1-238                 ....................MSYRYaT.E.R.ADHSALASGQVLRSAPGYPGFPVRLADELLQRAMV-.HVE...GD......R...VRLWDPCCGSGYLVTVLGLLHRDLLTHVRASDVSSDAVGIAARNLELLTAEGLAERERELRRSARDFG.RVAFVERAEAARDLAAGL...A........A...M.......G.....GDL........PHESA...VA.....D....V..FS.LteP....V.D...A.D..LVITDVPYGEMTHWD..G..E.Ap.eD.P...VR...GLLASM.GR....VL.P.RNSVVVVTARTRRVRLPEGVRALERVKVGNRS------------avllrardl..................
A0A0J1DJF7_9FIRM/1-242             ....................MKYRF.EiE.A.KNYEDFASGRVLYNRKGATAFPVRLGSEIIQRCLER.VRKargKV......P...LTIYDPCCGGAYLLTTIALLHGREFSKLYASDVDGEILELAKANLALLTPAGMARRIAELEELFALYG.KDSHREALASASRLGELVe.hT........A...H.......L.....EIH........CMEID...VL.....RpglaG..KI.A..P....Q.S...I.D..IVITDVPYGSIASWS..Q..DiT...D.P...IG...VMLSNL.RP....AV.R.DQGVVALVTTKQQKVQAQGFKRLEGFKIGKRSI-----------yllep......................
A0A060LXB2_9BACI/1-240             ..............mqftye-----.T.I.K.RDFSDFSSGRVLYNAPGSTGFPIRLTSEIFQISRSY.LQK...PS......Q...LNVYDPCCGGAHLLTGIGFLHGGSIQTLYGSDSNETIIETGQSNLRLLTYEGLAQRKRKLEKDYLLFN.KSAHAEALKSVDRLKSYLd.kT........G...E.......V.....KGE........IFQFN...IA.....-....S..KD.V..P....K.L...E.EihIVMTDLPYGELVSWD..T..N.V..lS.P...VK...QMLQNV.YS....VL.A.HDGVVAVVSDKFTLIEHPLFRRLKVLKHGKRKVTLL--------qaidhe.....................
A0A0C2G8J6_9ACTN/1-241             ....................MAYRYaT.E.R.RDHSDLASGNVLRSAPGHPGFPVRLADELFQRAAA-.HLP...AA......P...VSLWDPCCGSGHLATAVGLLHRARLCRLLATDTDPAALSIAERNLALLTLSGLAERESGLRDDAAAFG.KPALLERADTAARLAERL...R........KsggD.......L.....DRT........VRAGD...AF.....D....P..VA.P..E....H.R...V.D..LVLTDVPYGGLTAFA..G..A.VpagE.P...VP...ALMRAL.AA....VV.P.AHAVLAVTARTRKVPLPEGARALERIRVGNRAAAL---------vraseaa....................
A0A091CDM9_9ENTE/1-242             ....................MKFKFeT.L.K.KDYSDFSSDKVLVNAPRTPAFPVRIASEIMARCLSF.LKS...TD......H...LTIYDPCCGGAHLLTVLGFIYSTNLTKIYGTDIDKSALTYAQKNLNLLTDETLNQKIKTLQSVNKSQEeQTQSAEVLHSAKRLAALLl.dT........Ka.pQ.......K.....EVQ........CFPWD...IT.....E....G..PP.F..F....K.K...V.N..IVITDLPYGNMAHWQ..G..D.I...R.Eq.pAK...LLLDHIyQT....LD.L.NNSVVAIICNKNERIAHQNFIQVNRLKHGKRQIVIL--------qpls.......................
A0A061P0B3_9BACL/7-244             ....................MNYKYeT.E.N.KDYRDFASGRVLLNAKKTTAFPIRMASEIMQHCIAS.LEK...KE......S...LTLYDPCCGGAHLLTAMGFIHGKAIKAIYGSDFDRDVIEVATTNLSLLTDDGLIKRENQLSSLFNTYG.KESHKEALESVGRLRSMS...A........Q...-.......M.....TSP........IISSF...TW.....D....I..TG.G..PppvnE.K...V.D..IVITDIPYGNTVGWQ..T..T.S...SdP...VQ...DLLGHL.EL....IM.NkEDSIIAIVSEKKETITHDRFEKVKTMKHGKRKVTMLKP------k..........................
A0A136PPG4_9ACTN/1-216             ....................MTYRFaT.E.R.PDYSDLASGAVLRSAPGHPAFPVRLASEMFLRAW-H.ALG...RP......R...VTVWDPCCGSGYLLTVLGLLHRERIAGIVASDVADGPLRLARANLGLLSADGLQDRAAELDELADRFQ.RPAHRTAAEAARRLRAQL...T........P..gD.......P.....ATV........VGRAD...ALv..peQ....V..AD.L..L....A.AsgpP.D..LVLTDVPYGEQTTWQgaD..P.A...A.G...LP...GLLDSL.AG....AL.P.AETMVAL-------------------------------------atrgrrv....................
L0EEW0_THECK/1-247                 ....................MEYRF.A.T.D.EPRGHFASGRVLYNAKGAAPFPVRLADEIVQRCFHY.LEE...RG......HsgpYAIYDPCCGSGYLLTVIGLLHGAQIRAVFASDIDESMLETARRNLSLLTAEGMRARIEQLRELYEQYG.KPSHAEALESAAMLDGYRacgT........V...E......sI.....EMFp.....adITVGS...PE.....A....V..RD.S..G....F.C...PvN..IVIADLPYGHLTGWQ..S..G.S...A.D..pAA...RMLDSL.FP....LLrP.GASVIALISDKSHKLRHERYRRIALLKAGKRQIALFEPK-----gc.........................
D1BGB8_SANKS/1-209                 ....................MKFEH.A.P.Q.ASYEDVGGGQVLHSAPGFPGFPARLAVELFERAR-V.LVG...RE......R...VGLWDPMCGAGGILTSVALLRPDALTRVLASDVDEGALELARKNLLLTTVPGLEARRAELVERGAAAG.RVASADRL--LARVAGLP...A........P...P.......-.....-AS........LARAD...VT.....Dp.ssV..AG.L..D....LdG...V.D..VVMADLPYGTQTDWA..S..T.S...T.T..pTA...QALE--.--....--.-.--------------------------------------------vlrdalpdgavvvlstterehlr....
A0A0N7JZF6_9PSEU/1-181             ..........mqyrhapaan-----.-.-.-.----HAALDAVLVSAPGRPTLPVRLTVELAGRARE-.RLG...PG......P...VTVWDPCCGAGVSLAVLGLLC-PGIAVLAGTDADPAPLGLARRNLGLLAPGGLDDRASTLDGLAARHG.KESCAVAAAAARATIPAS...R........P...E.......W.....RVG........VADAGdpeAV.....R....T..AL.G..G....I.E...P.D..LVLADLPHGRQTSW-..-..-.-...-.-...--...------.--....--.-.--------------------------------------------agepgtgp...................
A0A061PHI3_9BACL/1-238             ..............mqflye-----.T.E.A.GDYRDFASGRVLRNAPGTTAFPVRLTSEILFRCRAL.IGK...KT......E...LTIYDPCCGGAHMLTAAGFLHGRSITTIVGSDVNSSVVPIAKSNVSLLTREGLEDRKQQLQAFFDEFQ.KSAHREALESIERLEQLQ...Q........K...A.......G.....PFH........SLQAF...DH.....D....I..TT.S..P....P.SvegV.N..IIIADLPYGNTVDWQ..T..T.E..dE.P...LH...QMLQNI.YE....TL.DpDQSVVALISDKKQQTEHRYYERVKALKHGKRKITLLK-------pr.........................
D3EHE3_GEOS4/1-244                 ....................MEYIY.E.SaQ.RSYEDFASGRVLYNAQGTTSFPVRLASEIAQRCFHI.LEE...KGv...qgP...YTLYDPCCGGAYLLTVVGLLHGRRIRRVIGSDINAEVLGIAGKNLSLLREEGLEQRTEQLKELLALYH.KPSHQDALESADRLRELIr.mS........R...L.......E.....ETF........CFQAD...ITqpqpeE....S..LA.S..C....K.G...T.Q..IVMTDLPYGDMVSWS..G..G.S...QeP...VE...DFFNGI.HA....IL.DpVRSVVAVISDKGQKLKHDRFKRIQHLKIGKRQVAIF--------ep.........................
A0A0M8XW25_9ACTN/1-225             ...................m-----.-.-.-.------ASGNVLRSAPGFPGFPVRLASELFQRGLAH.-VP...RE......P...VRMWDPCCGSGYLVTVLGLLHRDRIVHARATDVDPDAVALAARNLALLTREGLAEREEELRRSALDFG.RAEFVGRAETAGALAAGL...A........S...M.......G.....GDL........PHETG...VA.....D....V..FT.LseP....V.E...A.D..LVVTDVPYGDLTHWR..G..E.A...P.GddpMA...ALLASL.GR....VL.P.PHAVIVVTARTRRVVLPPGVRALERVKVGNRA------------avlvrardv..................
G4L5U2_TETHN/1-242                 ............mkfkfepi-----.-.-.K.KDYSDFSSDKLLVNAPRTPAFPVRVASEIMARSLSF.LNS...AD......G...LTLYDPCCGGGHLLTVLGFCYSKNLKNIYGSDIDTKALEYAQKNLNLLTPEGLSKKKKDLQYNDEKQD.EKTQLEALNSANRLEKQLfhtTy.....pkK...D.......I.....QC-........-FHWD...IT.....R....KkpPH.L..-....K.N...V.N..IVITDLPYGKMSDWQ.gE..G.T...T.Q...NNpnkQMLNNI.YQ....TLdL.NNSIVTIICNKQEKINHQKFEQVKRLKHGKRQFI----------flrp.......................
A0A0M4QLW8_9PSEU/1-185             ..........mqyrhapaan-----.-.-.-.----HAALDAVLASAPGRPTLPVRLTVELAGRARAH.LSA...DA......P...LTVWDPCCGAGVTLTVLGLLEV-GITRLVGTDADPEPLDLARRNLALLDPGGLTARAADLDALAARHD.KPSYADAATAARTLVPAS...TpawsvavaD...A.......R.....DTA........AVRG-...VL.....A....V..ASpD..D....T.G...P.D..LVLADLPHGIRTTW-..-..-.-...-.-...--...------.--....--.-.--------------------------------------------aasptr.....................
M3CC20_STRMB/3-244                 ...........syrhavers-----.-.-.-.-DSSDLACGVVLHSAPGYPAFPVRLATEIFLRAQAR.LPD...DG......P...VTLWDPCCGSGYLLTVLGLLHRRALRRVIASDVDPAPLELAAKNLALLSPGGLAAREAERREQSERFA.KPAYQESADAARRLRDRL...E........A...DggalpyaV....gAAD........VFDPR...SL.....S....A..VV.A..G....A.A...P.D..VVLTDLPYGERTHWD..G..A.V...P.Gq.pVT...GMLRSL.AS....VL.P.AHAVIAV-TDRSRKIPVAPVPALERLKIGTRS------------avlvraad...................
R9KC37_9FIRM/1-97                  ....................MEYFY.C.P.K.DNFKDFASGQVLYGGGGIPNFPIRLLIELYCRAKSY.LPK...SK......D...ITIYDPCCGGGYALTVLGFFHNHDIKKMYGSDINPNMVSHAKK-------------------------.------------------...-........-...-.......-.....---........-----...--.....-....-..--.-..-....-.-...-.-..---------------..-..-.-...-.-...--...------.--....--.-.--------------------------------------------mlhy.......................
A0A0N1NBN1_9ACTN/1-254             ..............mpyrha-----.T.E.R.SDGSDFASGFVLHSAPNHPAFPVRLATELFLRALEH.LPT...PTgpgsgpG...VTLWDPCCGSGHLATVLGWCHRRTIGRVVASDVDGETLSLARKNLRLLSPEGLLDRERERLELSVRFD.KPAYAEAARAAHRLAGRL...A........E...D.......G.....GALpwsagradVFDPA...SL.....SallaS..AG.L.rG....A.A...P.D..VVVMDVPYGERTHWG..G..Q.Ap.eR.P...VP...ALLRSL.AA....VL.P.PHAVIAVA-DRARKIPVAPLRPLERLRIGTRS------------avlvraad...................
D2AWL7_STRRD/1-239                 ...............myrha-----.T.V.R.GDYEDLASGAVLHSAPGFPAFPVRLASEAFQRALAL.RGG...GG......P...ATVWDPCCGSGYLLTVIGLLHRGRIQALLASDVSDDALRLARANLDLLGQAGLSARAGVLREKAERFA.KPSYAAAAEAAGRIGRML...A........AgggD.......VphdvrRAD........VFDPG...QL.....A....E..AA.A..G....Y.A...P.D..IVVTDVPYGEQTTWQ..GpgG.D...S.G...VP...GMLAAL.AP....VL.T.ERAVVVVTA-----------------------------------rgrkvplggriraresfkvgtravall
V9GBS0_9BACL/1-251                 ....................MEYLY.E.SvQ.RSYEDYASGRVLYNAHGTTSFPVRLASEIAQRCFHI.LEQ...KG......AggpYSLYDPCCGGAYLLTVLGLMHGQRFSSVIGSDVNPEVLAIANKNLSLLTHQGLDHRIGQLQELFERYH.KPSHQEALQSAARLKVLL...D........R...S.......Rl...eDAScy...padITDSQ...SQ.....A....A..LN.R..P....A.G...I.H..MVITDLPYGDIVSWH..G..G.S...G.E..pVR...EFFEQI.HP....MLdP.GHSVVAVIADKGQKLRHDRFKRLQQFKAGKRRWPSW--------nrydagevs..................
A9KJB4_CLOPH/1-237                 ....................MEYKY.T.K.N.DNYEDFASGRVLYHVGGEPTFPVRLALEIYERCLQY.SIK...KA......E...ISLYDCCCGGAYMLSILGLLKSNTIANLYGSDINSESIQLANDNLGLLTKSGINKRRDELKALYQTYK.KASHIDALHSIDRIEELL...T........R...E.......I.....KTY........LFKGN...VL.....E....V..CD.L..P....F.T...P.D..IIITDVPYGNMVEWE..E..G.S...G.G...IN...QMMNAL.SA....VC.G.SDTIICVCMDKKQKIHNDIFQRLERQLVGKRKFEIYKKKASEIA...........................
R9KK57_9FIRM/2-99                  fshdvsaeifeadctkalpq-----.-.-.-.------------------------------------.---...--......-...--------------------------------------------------------------------.------------------...-........-...-.......-.....---........-----...--.....-....-..--.-..-....V.F...P.D..IIITDVPYGNLVEWD..S..G.E..lI.A...ID...LMLEQL.WT....IS.H.ENTILAICMNKKQKINCSKWKRLEKQSIGKRKFEIL--------yvnk.......................
#=GC seq_cons                      ..........................p...p.tsapDhASGpVLhsAPGtPuFPVRLAoElhtRuhth.h.p...ps......s...lolaDPCCGuGaLLTVlGLLHtpplpplhuSDlsssslplAp+NLsLLo.pGLtpRtppLcchhtpas.Ksuat-AhcuApRLtshl...s........t...p.......h.....ts.........shpss...sh.....p....s..hs.h..s....h.t...s.D..lVlTDlPYGphssWp..s..s.s...s.s...lt...thLpsl.hs....hl.s.tpuVlslhspptphh..thhptlpth+hGpRp............tsh........................
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