GenomeNet

Database: Pfam
Entry: BRCA-2_helical
LinkDB: BRCA-2_helical
Original site: BRCA-2_helical 
#=GF ID   BRCA-2_helical
#=GF AC   PF09169.5
#=GF DE   BRCA2, helical
#=GF AU   Sammut SJ
#=GF SE   pdb_1iyj
#=GF GA   25.00 25.00;
#=GF TC   25.00 25.10;
#=GF NC   24.40 24.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   BRCA2
#=GF RN   [1]
#=GF RM   12228710
#=GF RT   BRCA2 function in DNA binding and recombination from a
#=GF RT   BRCA2-DSS1-ssDNA structure. 
#=GF RA   Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thoma NH, Zheng
#=GF RA   N, Chen PL, Lee WH, Pavletich NP; 
#=GF RL   Science 2002;297:1837-1848.
#=GF DR   INTERPRO; IPR015252;
#=GF DR   SCOP; 1iyj; fa;
#=GF CC   Members of this family adopt a helical structure, consisting of
#=GF CC   a four-helix cluster core (alpha 1, alpha 8, alpha 9, alpha 10)
#=GF CC   and two successive beta-hairpins (beta 1 to beta 4). An approx.
#=GF CC   50-amino acid segment that contains four short helices (alpha 2
#=GF CC   to alpha 4), meanders around the surface of the core structure.
#=GF CC   In BRCA2, the alpha 9 and alpha 10 helices pack with BRCA-2_OB1
#=GF CC   (Pfam:PF09103) through van der Waals contacts involving
#=GF CC   hydrophobic and aromatic residues, and also through side-chain
#=GF CC   and backbone hydrogen bonds. The domain binds the 70-amino acid
#=GF CC   DSS1 (deleted in split-hand/split foot syndrome) protein, which
#=GF CC   was originally identified as one of three genes that map to a
#=GF CC   1.5-Mb locus deleted in an inherited developmental malformation
#=GF CC   syndrome [1].
#=GF SQ   134
#=GS G4T9C9_PIRID/407-503    AC G4T9C9.1
#=GS H6QNT9_PUCGT/767-827    AC H6QNT9.1
#=GS F8VPU5_MOUSE/2400-2588  AC F8VPU5.1
#=GS F1RSS3_PIG/2448-2639    AC F1RSS3.1
#=GS G6DCM7_DANPL/1036-1104  AC G6DCM7.1
#=GS E1ZU95_CHLVA/873-941    AC E1ZU95.1
#=GS H9KIX7_APIME/16-161     AC H9KIX7.1
#=GS G3HM86_CRIGR/2428-2616  AC G3HM86.1
#=GS B0CRK1_LACBS/3-60       AC B0CRK1.1
#=GS F7ER68_MACMU/2398-2585  AC F7ER68.1
#=GS D2H8U3_AILME/2488-2688  AC D2H8U3.1
#=GS BRCA2_MOUSE/2400-2588   AC P97929.1
#=GS BRCA2_MOUSE/2400-2588   DR PDB; 1MIU A; 2400-2588;
#=GS G1QK32_NOMLE/2480-2668  AC G1QK32.1
#=GS F7B8V0_ORNAN/2477-2667  AC F7B8V0.1
#=GS A4S4F0_OSTLU/378-470    AC A4S4F0.1
#=GS H3C2G7_TETNG/243-433    AC H3C2G7.1
#=GS B0X0D2_CULQU/928-1142   AC B0X0D2.1
#=GS G4VJ64_SCHMA/570-657    AC G4VJ64.1
#=GS A2ERV5_TRIVA/884-967    AC A2ERV5.1
#=GS I1EK07_AMPQE/145-216    AC I1EK07.1
#=GS G1LS71_AILME/2511-2699  AC G1LS71.1
#=GS A5JSV3_TETNG/142-333    AC A5JSV3.1
#=GS C6JRX1_SORBI/535-589    AC C6JRX1.1
#=GS A0NBL4_ANOGA/1259-1450  AC A0NBL4.2
#=GS Q8MKI9_CANFA/2498-2686  AC Q8MKI9.2
#=GS G3RIE5_GORGO/2442-2630  AC G3RIE5.1
#=GS G7YE82_CLOSI/726-898    AC G7YE82.1
#=GS H0V4T0_CAVPO/2373-2561  AC H0V4T0.1
#=GS F6XH22_MONDO/2456-2646  AC F6XH22.1
#=GS H9JPA5_BOMMO/411-481    AC H9JPA5.1
#=GS E9GFR3_DAPPU/801-996    AC E9GFR3.1
#=GS H3DFR1_TETNG/240-431    AC H3DFR1.1
#=GS Q16TT4_AEDAE/449-645    AC Q16TT4.1
#=GS Q55PP9_CRYNB/5-61       AC Q55PP9.1
#=GS F0ZBE1_DICPU/708-789    AC F0ZBE1.1
#=GS G3W9Q7_SARHA/2434-2625  AC G3W9Q7.1
#=GS H3IH56_STRPU/2643-2816  AC H3IH56.1
#=GS E2BM50_HARSA/651-844    AC E2BM50.1
#=GS Q9H4L3_HUMAN/1-56       AC Q9H4L3.1
#=GS G3SGJ0_GORGO/2478-2666  AC G3SGJ0.1
#=GS F7B8W7_ORNAN/2523-2713  AC F7B8W7.1
#=GS F0WWW8_9STRA/966-1021   AC F0WWW8.1
#=GS G1NQB1_MELGA/2424-2612  AC G1NQB1.1
#=GS B9SL09_RICCO/489-594    AC B9SL09.1
#=GS A1YBP1_HUMAN/2479-2612  AC A1YBP1.1
#=GS G5E764_LOXAF/2415-2603  AC G5E764.1
#=GS G1KCX8_ANOCA/272-463    AC G1KCX8.1
#=GS E5SA16_TRISP/493-672    AC E5SA16.1
#=GS Q4PR36_CRIGR/278-466    AC Q4PR36.1
#=GS C1FJK2_MICSR/870-938    AC C1FJK2.1
#=GS H2SRJ3_TAKRU/1-183      AC H2SRJ3.1
#=GS Q66MH4_RAT/2409-2597    AC Q66MH4.1
#=GS H2Q7E2_PANTR/2479-2667  AC H2Q7E2.1
#=GS A4ZZ90_XENTR/2285-2476  AC A4ZZ90.1
#=GS Q4P9L3_USTMA/622-674    AC Q4P9L3.1
#=GS G7J9J4_MEDTR/551-722    AC G7J9J4.1
#=GS H9IBY3_ATTCE/846-1032   AC H9IBY3.1
#=GS F1P3B2_CHICK/2425-2613  AC F1P3B2.1
#=GS I1HCA6_BRADI/863-964    AC I1HCA6.1
#=GS E1C2I8_CHICK/2428-2616  AC E1C2I8.1
#=GS BRCA2_FELCA/2423-2611   AC Q864S8.2
#=GS B8PHD4_POSPM/629-698    AC B8PHD4.1
#=GS BRCA2_HUMAN/2479-2667   AC P51587.2
#=GS E2A3F8_CAMFO/1109-1301  AC E2A3F8.1
#=GS G1PNI9_MYOLU/2428-2616  AC G1PNI9.1
#=GS Q4RRH3_TETNG/1-195      AC Q4RRH3.1
#=GS B7PB26_IXOSC/840-978    AC B7PB26.1
#=GS Q16FF5_AEDAE/925-1124   AC Q16FF5.1
#=GS B8ADF3_ORYSI/850-946    AC B8ADF3.1
#=GS Q8QFV6_CHICK/2426-2614  AC Q8QFV6.1
#=GS F4JGU5_ARATH/564-616    AC F4JGU5.1
#=GS I1NKI6_ORYGL/863-970    AC I1NKI6.1
#=GS F7EV30_MONDO/2441-2631  AC F7EV30.1
#=GS F1R8E8_DANRE/2021-2212  AC F1R8E8.1
#=GS H2NJK5_PONAB/2476-2664  AC H2NJK5.1
#=GS Q3TN53_MOUSE/251-439    AC Q3TN53.1
#=GS G7NJX0_MACMU/2483-2671  AC G7NJX0.1
#=GS G7E6Z2_MIXOS/612-678    AC G7E6Z2.1
#=GS D6WEG4_TRICA/387-566    AC D6WEG4.1
#=GS B5YME7_THAPS/1-58       AC B5YME7.1
#=GS F4PXC2_DICFS/390-449    AC F4PXC2.1
#=GS F7E9I9_XENTR/2244-2435  AC F7E9I9.1
#=GS C1N0K9_MICPC/84-181     AC C1N0K9.1
#=GS D8LCN1_ECTSI/2812-2890  AC D8LCN1.1
#=GS G7PVZ4_MACFA/2483-2671  AC G7PVZ4.1
#=GS H0X313_OTOGA/2468-2656  AC H0X313.1
#=GS Q6PB43_MOUSE/251-439    AC Q6PB43.1
#=GS F6TTA8_HORSE/2451-2639  AC F6TTA8.1
#=GS D7M6H1_ARALL/540-621    AC D7M6H1.1
#=GS Q8NJ74_USTMD/622-674    AC Q8NJ74.1
#=GS F6RE00_XENTR/2268-2459  AC F6RE00.1
#=GS G3PC75_GASAC/1-180      AC G3PC75.1
#=GS G5B7X6_HETGA/2399-2527  AC G5B7X6.1
#=GS D3BKW3_POLPA/488-569    AC D3BKW3.1
#=GS Q7Y1C4_ARATH/535-625    AC Q7Y1C4.1
#=GS E0W1Z3_PEDHC/1116-1297  AC E0W1Z3.1
#=GS Q54BU8_DICDI/695-776    AC Q54BU8.1
#=GS E4XD02_OIKDI/857-1037   AC E4XD02.1
#=GS F1N924_CHICK/2422-2610  AC F1N924.1
#=GS F4WV33_ACREC/843-1039   AC F4WV33.1
#=GS B7ZVU5_DANRE/2021-2212  AC B7ZVU5.1
#=GS A8QLH9_DANRE/2021-2212  AC A8QLH9.1
#=GS Q8UW79_CHICK/2425-2613  AC Q8UW79.1
#=GS BRCA2_RAT/2409-2597     AC O35923.1
#=GS BRCA2_RAT/2409-2597     DR PDB; 1IYJ D; 2409-2597;
#=GS BRCA2_RAT/2409-2597     DR PDB; 1IYJ B; 2409-2597;
#=GS A7SNN6_NEMVE/1-134      AC A7SNN6.1
#=GS H3AGP4_LATCH/229-424    AC H3AGP4.1
#=GS B9IB91_POPTR/544-657    AC B9IB91.1
#=GS E1B8X8_BOVIN/2422-2611  AC E1B8X8.2
#=GS Q7Y1C5_ARATH/528-621    AC Q7Y1C5.1
#=GS O81303_ARATH/570-620    AC O81303.1
#=GS E7A288_SPORE/613-678    AC E7A288.1
#=GS Q5VQI6_ORYSJ/336-391    AC Q5VQI6.1
#=GS I1LXQ3_SOYBN/412-530    AC I1LXQ3.1
#=GS Q5KDQ9_CRYNJ/5-61       AC Q5KDQ9.1
#=GS I0YVH7_9CHLO/998-1101   AC I0YVH7.1
#=GS Q8VHD0_MOUSE/2400-2588  AC Q8VHD0.1
#=GS B9ET11_ORYSJ/846-934    AC B9ET11.1
#=GS G3UEA2_LOXAF/286-474    AC G3UEA2.1
#=GS G1TCK4_RABIT/2461-2649  AC G1TCK4.1
#=GS B8P1I5_POSPM/631-700    AC B8P1I5.1
#=GS G0SX58_RHOG2/679-773    AC G0SX58.1
#=GS A5A3F7_STRPU/2664-2850  AC A5A3F7.2
#=GS F4NS03_BATDJ/1816-1883  AC F4NS03.1
#=GS F1Q0X3_CANFA/2498-2686  AC F1Q0X3.1
#=GS E9CAL7_CAPO3/979-1109   AC E9CAL7.1
#=GS I0IV83_CANFA/2497-2685  AC I0IV83.1
#=GS I0IV85_CANFA/2497-2685  AC I0IV85.1
#=GS H0ZNF4_TAEGU/2394-2584  AC H0ZNF4.1
#=GS F7BTV7_CALJA/2472-2660  AC F7BTV7.1
#=GS G3SQY0_LOXAF/2423-2611  AC G3SQY0.1
#=GS Q9M013_ARATH/568-620    AC Q9M013.1
#=GS F6TLV1_HORSE/2483-2671  AC F6TLV1.1
#=GS A4ZZ89_MONDO/2462-2652  AC A4ZZ89.1
#=GS D2UYY4_NAEGR/598-798    AC D2UYY4.1
G4T9C9_PIRID/407-503               .......................................................eeqgihsavgdiepwnalywafeedgerkgveaasealkkag--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-----------...---CTLLEREWLQNHWSLIIWKLAN..T..VL.MWPA...T...Q...AE...R.-WSFREVLNQLLYRYEREINR-c...................
H6QNT9_PUCGT/767-827               .......................................................................................llqagcsinr--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-----------...------CSPKWVANHWALIIWKLAA..M..VR.WQPD...C...L...SR...-.VWNPSNAVQQLKYRYERE----fvc.................
F8VPU5_MOUSE/2400-2588             .................................................................................................DLMSSLQS........---ARDL.QDMR.IKNKE..RRH....LRL..QPGSLYLTKS.S.TLPRISL.QAAV....GDRAP.SACSP--.-.....KQLYIYGVSKE.....CINVNSKNAEY..FQFDIQDHFGK....ED.LC.........AGKGFQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISSIWVANHYRWIVWKLAA..M..EF.AFPK...E...F...AN...R.CLNPERVLLQLKYRYDVEIDNS....................
F1RSS3_PIG/2448-2639               ............................................................................................vnsdl--IT---N........LQIARDI.QDMR.IKKKK..RQR....IFP..QPGSLYLAKT.S.TLPRISL.KEAV....EGRVP.SACSH--.-.....KQLYMYGVSKH.....CIKINSKNAES..FEFHTQDYFGT....EG.LC.........AGKGIQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISRVWVYNHYRWIIWKLAA..M..EF.AFPK...E...F...AN...R.CLNPERVLLQLKYRYDMEIDRS....................
G6DCM7_DANPL/1036-1104             .......................................................................................gtdkikeyft--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.----------D...NVNIKIVPEGWVENHMRLIIWKLLC..Y..ET.FFGE...S...M...RN...-.VCSVKNVLEQLKYRYDKEL---ykv.................
E1ZU95_CHLVA/873-941               ...........................................................................................atseap--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.----------A...GANSAYATASWVQNQYRWVVWKLAR..L..QL.LLAG...SgssA...PA...S.LLTAAVVLDELKLRYEREFN--rg..................
H9KIX7_APIME/16-161                .....................................................................................tasgssinitek--------........-------.----.-----..---....---..----------.-.-------.----....-----.------A.L.....LKLNKKKLPLE.....ILDITSNNALM..YKFRCIDFYGE....NI.VQ........nNIDGIKLEDGA.....YL.ILD.ENGN..A.GI.TEIKRCFLACP...GVDPNLLSSGWVENHYKWIVWKLAS..I..DRiKLGS...V...M...LP...K.MLTPTRVVMELKYRYDREIDRS....................
G3HM86_CRIGR/2428-2616             .................................................................................................DLMTSLQN........---ARDL.QNIR.IKKKE..RHQ....LCP..QPGSLYLTKS.S.TLPRISL.QAAV....GGRLP.SACSH--.-.....KQLYMYGVSKE.....CISINSKNAEY..FQFDIQDYFGK....ED.LC.........AGKGIQLADGG.....WL.IPS.NEGK..A.GK.EEFYRALCDTP...GVDPKLISSLWVSNHYRWIVWKLAA..M..EF.AFPK...E...F...AN...R.CLTPERVLLQLKYRYDVEIDNS....................
B0CRK1_LACBS/3-60                  ................................................................................................i--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-----------...-----LATEPWVKNHWCLILWKLAG..M..VC.LDPH...R...EvipEE...K.RWRWEEVIRQLLYRYEREL---ngg.................
F7ER68_MACMU/2398-2585             .................................................................................................DLITSLQN........---ARDI.QDMR.IKKKQ..RQR....IFP..QPGSLYLAKT.S.TLPRISL.KAAV....GGQVP.SACSH--.-.....KQLYMYGVSKH.....CIKINSKNAES..FQFYTQDYFGK....ES.LW.........AGKGIQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISRIWVYNHYRWIIWKLAA..M..EC.AFPK...E...F...AN...R.CLSPERVLLQLKY-YDMEIDRS....................
D2H8U3_AILME/2488-2688             .................................................................................................DLITNLQN........---ARDT.QDMR.IKKKQ..RQH....IFP..EPGSLYLAKT.S.TVPRISL.RGAV....EGQVP.SACSH--.-.....KKLYMYGVSKH.....CVKINSKNAES..FQFHTQDYFGK....EG.LW.........SGEGIQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPNLISRVWVYNHYRWIIWKLAA..M..EF.AFPK...E...F...AN...R.CLSPERVLLQLKYR--------qvqciilcnhrlydveidrs
BRCA2_MOUSE/2400-2588              .................................................................................................DLMSSLQS........---ARDL.QDMR.IKNKE..RRH....LRL..QPGSLYLTKS.S.TLPRISL.QAAV....GDRAP.SACSP--.-.....KQLYIYGVSKE.....CINVNSKNAEY..FQFDIQDHFGK....ED.LC.........AGKGFQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISSIWVANHYRWIVWKLAA..M..EF.AFPK...E...F...AN...R.CLNPERVLLQLKYRYDVEIDNS....................
#=GR BRCA2_MOUSE/2400-2588   SS    .................................................................................................--S-HHHH........---HHHH.HHHH.HHHHH..TS-....---..---HHHHHHT.S.-S--EET.TGGG....TS-S-.---TT--.-.....-S-SSS---SS.....SSS--TTTTTT..----THHHHTT....TS.TT.........-TT-EE-TTS-.....EE.---.TTS-..-.-H.HHHHHHHHHST...T--TTS--HHHHHHHHHHHHHHHHH..T..ST.T-TT...T...-...SS...S.SSSHHHHHHHHHHHHHHHTTS-....................
G1QK32_NOMLE/2480-2668             .................................................................................................DVITSLQN........---ARDI.QDMR.IKKKQ..RQR....IFP..QPGSLYLAKT.S.TLPRISL.KAAV....GCQVP.SACSH--.-.....KQLYTYGVSKH.....CVKINSKNAES..FQFHTQDYFGK....ES.LW.........TGKGIQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISRIWVYNHYRWIIWKLAA..M..EC.AFPK...E...F...AN...R.CLSPERVLLQLKYRYDMEIDRS....................
F7B8V0_ORNAN/2477-2667             .............................................................................................svdt-----ITN........LQRAREL.QEMR.IEKKQ..RQR....ILP..QMGRLYLAKT.S.GHPRLSL.KTAV....EGRAP.SKYST--.-.....KELYMCGVSKH.....CLRVNSKNAES..FQFCSQDCFSR....EC.WS.........AGNGVQLADGG.....WL.IPT.NAGK..A.GK.EEFYRALCDTP...GVDSKLISRPWVFNHYRWIIWKLAA..M..EV.TFPK...Q...F...AN...R.CLTPERVLLQLKYRYDVEIDKS....................
A4S4F0_OSTLU/378-470               ..................................................................................vatlnadtakslrlp--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.-SV.ERGL..V.GW.REMRELMIKA-...GASDASLTNEWVANAYKWIVWTQAC..M..AR.AFPE...K...Y...AF...G.VLSESAVLQRMLYKYEREINRA....................
H3C2G7_TETNG/243-433               ..............................................................................................tag----HLHN........VELARDM.QGMR.IRKKK..RQT....ILP..LPGSLFLKKS.S.GVTRIPL.KSAV....NGKPP.ARYTP--.-.....KQLYGLGVPLN.....VLEITSETAGS..FRFSLQQFVKL....ES.LT.........DKGGIQLADGG.....WL.IPR.NDGT..A.GK.EEFYRALCDTT...GVDPKLISEEWVYNHYRWIVWKQAS..M..ER.SFPE...Q...L...GS...L.CLTPEQVLLQLKYRYDIEVDQS....................
B0X0D2_CULQU/928-1142              ...............................................................................................ev--VAKLSSdgtlvggaVKVAQQV.LDAR.RLARE..RQR....ECGdgRTKPEQERRP.R.LYEFVRRkKQQS....GRISL.RAFVGGErVgggagDGGSSRGVAER.....IRMLSVDNVAE..FKFEVEAFYGK...qFA.QE.........NTTGIPLGDPDa..liHV.ILD.DNSH..V.GL.PEFTSAFLAAP...GIDPTLVPSGWIVNAWKWILLKLAS..M..ER.QLPK...L...F...CD...-.VTSPVNVLDQLLFRYHVEIDC-a...................
G4VJ64_SCHMA/570-657               ..............................................................................................hyf--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....VL.IPD.KFGC..V.GK.QEIINSFLSCR...KICPNLITRGWIENHYLQIMWKIGT..I..AL.LYSD...L...C...STllcD.YCAPIHVLNELHYRYDREIE--tc..................
A2ERV5_TRIVA/884-967               .......................................................................................nyrfpppdyr--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.GV.NDIYVALLEK-...NVDPLLLKPSWVRNHYKWIVWKLKC..L..DL.SYKEinqQ...N...NE...Q.ILTFDNVLSEMLFRIQREIY--ea..................
I1EK07_AMPQE/145-216               ..............................................................................................lss--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-DLKSAFSLSP...GVDDALISKDWFTNHYKWIVWKLAT..M..EI.CFPE...K...W...AG...R.CLTVDWCLLQLKYRYDIEIDQA....................
G1LS71_AILME/2511-2699             .................................................................................................DLITNLQN........---ARDT.QDMR.IKKKQ..RQH....IFP..EPGSLYLAKT.S.TVPRISL.RGAV....EGQVP.SACSH--.-.....KKLYMYGVSKH.....CVKINSKNAES..FQFHTQDYFGK....EG.LW.........SGEGIQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPNLISRVWVYNHYRWIIWKLAA..M..EF.AFPK...E...F...AN...R.CLSPERVLLQLKYRYDVEIDRS....................
A5JSV3_TETNG/142-333               .................................................................................................DLFQHLHN........VELARDM.QDMR.IRKKK..RQT....ILP..LPGSLFLKKS.S.GVTRIPL.KSAV....NGKPP.ARYTP--.-.....KQLYGLGVPLN.....VLEITSETAGS..FRFSLQQFVKL....ES.LT.........DKGGIQLADGG.....WL.IPR.NDGT..A.GK.EEFYRALCDTT...GVDPKLISEEWVYNHYRWIVWKQAS..M..ER.SFPE...Q...L...GS...L.CLTPEQVLLQLKYRYDIEVDQS....................
C6JRX1_SORBI/535-589               ..............................................................................................rpr--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-----------...-------SSRWVSNHYKWIVWKLAS..L..ER.CYPS...R...A...AG...K.FLTVDNVLEELKYRYSLD----asld................
A0NBL4_ANOGA/1259-1450             .........................................................................................vlvshlpp--------........----EHV.QQAR.REELG..KQV....QYI..ESKPADACRP.R.LFEFCSR.KQQK....NRVAI.REFVGGA.V.....PR--SADVLTA.....AMNVTLENVLE..FRFNVAEYYGE...sVS.IS.........NTAGIPLGTDGk..agCL.LMD.ANST..I.GV.EEMRCAFLAAP...GIDPRLVPQGWVENAWRWIVCKLSA..Y..ER.NFST...H...L...QG...-.ALSPENVFQQLQYRYHVEIDSA....................
Q8MKI9_CANFA/2498-2686             .................................................................................................DLITNLQN........---ARDI.QDMR.IKKKQ..RQH....IFP..QPGSLYLAKT.S.TLPRISL.REAV....EGRVP.SACSH--.-.....KQLYMYGVSKH.....CVKINSKNAES..FQFHAQDYFGK....EG.LW.........SGEGIQLADGG.....WL.IPS.NDGK..I.GK.EEFYRALCDTP...GVDPNCISRVWVYNHYRWIIWKLAA..M..EF.AFPK...E...F...AN...R.CLSPERVLLQLKYRYDVEIDKS....................
G3RIE5_GORGO/2442-2630             .................................................................................................NLITSLQN........---ARDI.QDMR.IKKKQ..RQR....VFP..QPGSLYLAKT.S.TLPRISL.KAAV....GGQVP.SACSH--.-.....KQLYTYGVSKH.....CIKINSKNAES..FQFHTEDYFGK....ES.LW.........TGKGIQLADGG.....WL.IPS.SDGK..A.GK.EEFYRALCDTP...GVDPKLISRIWVYNHYRWIIWKLAA..M..EC.AFPK...E...F...AN...R.CLSPERVLLQLKYRYDMEIDRS....................
G7YE82_CLOSI/726-898               .................qatterspliplnhmvahesspkrtqkhdkhvgsfdlpdnihfpvntdrwslrtaaqlrwqldraylldptakpslpasy--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----EAGDGG.....VL.IPD.AYGC..V.GK.EEIIDAFLASP...SVCCQLVSRGWLSNHYDQLVWKLGSttL..RA.SLPD...SpfrL...PV...D.YFTPHHVLLRLKYRYDRELEQ-v...................
H0V4T0_CAVPO/2373-2561             .................................................................................................DLMTSLQN........---ARKI.QDIR.IKEKE..KQH....IFP..QPGSLYLAKT.S.SLPRISL.KAAV....GGRVP.SACSH--.-.....KQLYMYGVSIH.....CMKINSKNAES..FKFHIQDYFGK....ED.LQ.........AGKGIQVADGG.....WL.IPD.NDGK..A.GK.EEFYRALCDTP...GVDPKLISRVWVCNHYRWIIWKLAA..M..EV.AFPQ...E...F...AS...R.CLNPERVLLQLKYRYDVEIDRS....................
F6XH22_MONDO/2456-2646             ..............................................................................................hle-M---IEN........LQHAREM.QDMR.IKKKQ..TQK....IHP..QAGSLYLRKT.S.TLPRSSL.RVVV....EGKVP.STYSS--.-.....KQLYMYGITKQ.....CLRINSKNSES..FKFHSEDYFSK....EH.LL.........DGNGIQLADGG.....WL.IPT.DEGK..L.GK.EEFYRALCDTP...GVDPKLITKTWVYNHYRWIIWKLAA..M..EF.TFPK...E...F...AS...R.CLTPEWVLLQLKYRYDIEIDES....................
H9JPA5_BOMMO/411-481               ....................................................................................vvnvehvqrmfls--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-----------...SVNAKLIPKGWLENHIKLILWKLLS..Y..EI.KFPN...V...M...AN...-.VCTVGNVIDQLKYRYDKELY--na..................
E9GFR3_DAPPU/801-996               .......................................................................................vsakiralrr--------........--KAREE.QNAV.IQRKRstGRK....TSP..KAGYLYQLKK.D.GTCRKTW.KELI....DNSSLpEILAP--.Y.....KLLEDHGMLAE.....VYQVQASNASS..FNFCAWDHFHI...eDC.LQ.........NSKGVQLGEF-.....LV.IFS.EENI..I.GY.EEIGASLLASE...NVDPTLISYDWIRNHYRWIVWKLAS..M..EL.RMPS...L...F...AR...T.CLTISNVLEQLKYRYDKEIDR-c...................
H3DFR1_TETNG/240-431               .................................................................................................DLFQHLHN........VELARDM.QGMR.IRKKK..RQT....ILP..LPGSLFLKKS.S.GVTRIPL.KSAV....NGKPP.ARYTP--.-.....KQLYGLGVPLN.....VLEITSETAGS..FRFSLQQFVKL....ES.LT.........DKGGIQLADGG.....WL.IPR.NDGT..A.GK.EEFYRALCDTT...GVDPKLISEEWVYNHYRWIVWKQAS..M..ER.SFPE...Q...L...GS...L.CLTPEQVLLQLKYRYDIEVDQS....................
Q16TT4_AEDAE/449-645               .................................................................................................DVVAKLNSd.....ggLKVAPHI.AEAR.KLSMQ..RQQ....SYI..ESKPLEERRP.R.LTEFISK.KQMR....GRSTL.RQFVENR.N.....PS---CSVPEK.....LRDVIADNAMN..FKFDMIEFYTK...tEC.LE.........NVDGIVLGDSNt...tTL.FFN.ERCQ..A.GL.PEFKLAFLASP...GIDPALVPAGWIENCWVWTIIKLTS..M..ER.NLPD...Y...F...HG...-.ITTLENMLNQIMYRYHLEIDSA....................
Q55PP9_CRYNB/5-61                  ..............................................................................................cgc--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-----------...----ALATAEWIKNHWAQILWKLAG..E..VQ.ARPD...L...L...TE...-.KWSWEEVISQLKYRYERE----fgva................
F0ZBE1_DICPU/708-789               .........................................................................................irdigksk--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.---T..I.GV.AELYIYLLKDS...KSNVSLLNQEWVRNHYGWIVWKLAA..M..ER.AFPQ...L...Y...AG...K.YLVLQRVITQLRNRVEKEINQA....................
G3W9Q7_SARHA/2434-2625             ...........................................................................................tlvemn------KN........LQNAREL.QDMR.IKKKQ..TQQ....IYP..QAGSLYLTKT.S.TIPRISL.KVAV....EGRVP.STYSS--.-.....KQLYMYGVSKQ.....CSRINSKNAES..FQFHSQDYFSK....EY.LL.........DGNGIQLADGG.....WL.IPT.DEGK..L.GK.EEFYRALCDTP...GVDPKLITKTWVYNHYRWIIWKLAA..M..EF.TFPK...E...F...AS...R.CLTPERVLLQLKYRYDIEIDKS....................
H3IH56_STRPU/2643-2816             ..............................................................................................gla--------........-------.----.-KKSM..KKV....IKP..ELGSLWRSRK.-.EQDRISL.GEFV....NHQYP.CSMSD--.-.....SELFGHGILSS.....TLSVRPNNAEG..YEFAGEDHFSP....SC.LE.........SDRGIPLDDGG.....RL.VLS.PNGL..A.GK.KEFYCALLDTP...GVDPKLLKEEWVFNHYKWIIWKAAA..M..EV.AYPL...Q...F...GG...R.FLTPNWVLLQLKYRYDREIDHS....................
E2BM50_HARSA/651-844               .........................................................................................saqilqdr--------........--LAAALeQENA.ITDKS..RRR....SRQ..SPGYLYRHKQiN.SGARVSL.RDLA....DGAPP.RPRTC--.-.....QELIDQRIPPN.....ILAISSATAAS..YKFRCSDFYGN...dVA.RS.........NVRGIELEDGA.....RL.VMD.ENGY..V.GV.WEFLRAFLASP...GVEPSLVPARWIENHYRWIVWKLAS..L..DRmKFGS...A...E...LP...R.ALTPSHVMAQLKYRYDREIDRS....................
Q9H4L3_HUMAN/1-56                  .................................................................................................--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-----ALCDTP...GVDPKLISRIWVYNHYRWIIWKLAA..M..EC.AFPK...E...F...AN...R.CLSPERVLLQLKY---------....................
G3SGJ0_GORGO/2478-2666             .................................................................................................DLITSLQN........---ARDI.QDMR.IKKKQ..RQR....VFP..QPGSLYLAKT.S.TLPRISL.KAAV....GGQVP.SACSH--.-.....KQLYTYGVSKH.....CIKINSKNAES..FQFHTEDYFGK....ES.LW.........TGKGIQLADGG.....WL.IPS.SDGK..A.GK.EEFYRALCDTP...GVDPKLISRIWVYNHYRWIIWKLAA..M..EC.AFPK...E...F...AN...R.CLSPERVLLQLKYRYDMEIDRS....................
F7B8W7_ORNAN/2523-2713             .............................................................................................svdt-----ITN........LQRAREL.QEMR.IEKKQ..RQR....ILP..QMGRLYLAKT.S.GHPRLSL.KTAV....EGRAP.SKYST--.-.....KELYMCGVSKH.....CLRVNSKNAES..FQFCSQDCFSR....EC.WS.........AGNGVQLADGG.....WL.IPT.NAGK..A.GK.EEFYRALCDTP...GVDSKLISRPWVFNHYRWIIWKLAA..M..EV.TFPK...Q...F...AN...R.CLTPERVLLQLKYRYDVEIDKS....................
F0WWW8_9STRA/966-1021              ...........................................................................................dsvdly--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-----------...---------RWFCNQYRWIVFLCAQ..M..EL.AFPQ...H...L...CG...K.YLTLVQIIFQMHQRYKREVY--nc..................
G1NQB1_MELGA/2424-2612             .................................................................................................NMMANLCC........---ARDL.QEMR.IKKKY..RQN....ISP..QPGSLYVIKT.S.ARNRISL.KTAV....EEETP.SFHST--.-.....EKLYTYGVSKH.....CIQVNSTNAES..FQFLIEEFFSK....EY.LL.........AGNGIQLADGG.....WL.IPT.DEGK..A.GK.KEFYRALCDTP...GVDPKLITEAWVYNHYRWIVWKLAA..M..EV.SFPH...K...F...AN...R.CLTPETVLLQLKYRYDLEIDKS....................
B9SL09_RICCO/489-594               ..............................................................fdksmlehfagqvicikpdtvekytfwdesglsgl--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.GS.EAFHD-MLVQS...GASVQFASKEWVTNHYKWIVWKLAC..Y..GR.FYPL...K...S...AT...R.FLTVSNVLEELKYRYEREVN--hg..................
A1YBP1_HUMAN/2479-2612             .................................................................................................DLITSLQN........---ARDI.QDMR.IKKKQ..RQR....VFP..QPGSLYLAKT.S.TLPRISL.KAAV....GGQVP.SACSH--.-.....KQLYTYGVSKH.....CIKINSKNAES..FQFHTEDYFGK....ES.LW.........TGKGIQLADGG.....WL.IPS.NDGK..A.GK.EEFYSC-----...-------------------------..-..--.----...-...-...--...-.----------------------sglcvtlqv...........
G5E764_LOXAF/2415-2603             .................................................................................................NLITNLQN........---ARDR.QDTR.IKMKQ..RQR....VCP..QPGSLYLAKT.S.TVPRLSL.KMAV....GGRAP.STCSP--.-.....KQLYMYGVPEH.....CIKINSKTAES..FRFHAQDYFGK....EA.LW.........AGKGIQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISRDWVYNHYRWILWKLAA..M..EF.SFPK...E...F...AN...R.CLTPERVLLQLKYRYDVEVDRS....................
G1KCX8_ANOCA/272-463               .............................................................................................gltn-----IAS........LHCARNL.QEMR.ILKKQ..KQV....IGP..QPGTLYLMKI.CaTSCRIPL.KTAV....DEKCP.GSYFS--.-.....EQLYAFGVSKQ.....CLNVNSSNAEH..FQFHIQDFFGR....EC.FL.........DGNGIQLADGG.....YL.IPT.DDGK..A.GK.EEFYRALCDTP...GVDPKLISKAWVYNHYKWIIWKLAA..M..EV.AFPQ...E...F...AS...K.CLTPERVLLQLKYRYDVEVDKS....................
E5SA16_TRISP/493-672               .........................................................lnqmtiqpsrttyagggklfklwkskskipdyskfrpklk--------........-------.----.-----..---....---..----------.-.-------.----....----P.QSCLS--.E.....DELLAMGVRES.....TLRVTRKTASE..FYFTA-DYVNSepnsEI.IV.........ADDVIVKVDHQ.....GG.ISM.DEII..N.AD.WYVFRGFCGSS...DVDNKLLNDDWIRNHLQWIVLKLAS..L..EV.QFPT...C...L...AA...R.CLNVDNVLLQLRYRYDRELEH-a...................
Q4PR36_CRIGR/278-466               .................................................................................................DLMTSLQN........---ARDL.QNIR.IKKKE..RHQ....LCP..QPGSLYLTKS.S.TLPRISL.QAAV....GGRLP.SACSH--.-.....KQLYMYGVSKE.....CISINSKNAEY..FQFDIQDYFGK....ED.LC.........AGKGIQLADGG.....WL.IPS.NEGK..A.GK.EEFYRALCDTP...GVDPKLISSLWVSNHYRWIVWKLAA..M..EF.AFPK...E...F...AN...R.CLTPERVLLQLKYRYDVEIDNS....................
C1FJK2_MICSR/870-938               .......................................................................................ssdirskmis--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.---------EH...GCLDRLLEPEWCANAYRWTVWTQSC..V..AR.AFPD...A...A...DA...-.-VKAPAVIHRMLYRYEREIL--ra..................
H2SRJ3_TAKRU/1-183                 ................................................................................................q--------........--LARDM.QDMR.IRKKK..RQT....IRP..LPGSLFQKKS.S.GVARIPF.KAAV....NGKPP.ARYTA--.-.....KPLCGLGVPLN.....VLEITSETAES..FRFSLQHFVKL....ES.LI.........DKGGIQLADGG.....WL.IPT.NDGT..A.GK.EEFYRALCDTP...GVDPKLMSEEWVYNHYRWIVWKQAS..M..ER.SFPE...E...M...GS...L.CLTPEQVLLQLKYRYDIEVDHS....................
Q66MH4_RAT/2409-2597               .................................................................................................DLMSSLQN........---ARDL.QDIR.IKNKE..RHH....LCP..QPGSLYLTKS.S.TLPRISL.QAAV....GDSVP.SACSP--.-.....KQLYMYGVSKA.....CISVNSKNAEY..FQFAIEDHFGK....EA.LC.........AGKGFRLADGG.....WL.IPS.DDGK..A.GK.EEFYRALCDTP...GVDPKLISSVWVSNHYRWIVWKLAA..M..EF.AFPK...E...F...AN...R.CLNPERVLLQLKYRYDVEIDNS....................
H2Q7E2_PANTR/2479-2667             .................................................................................................DLITSLQN........---ARDI.QDMR.IKKKQ..RQR....VFP..QPGSLYLAKT.S.TLPRISL.KAAV....GGQVP.SACSH--.-.....KQLYMYGVSKH.....CIKINSKNAES..FQFHTEDYFGK....ES.LW.........TGKGIQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISRIWVYNHYRWIIWKLAA..M..EC.AFPK...E...F...AN...R.CLSPERVLLQLKYRYDMEIDRS....................
A4ZZ90_XENTR/2285-2476             .................................................................................................DILQMTSN........LRCSKDL.QEMR.IRKKL..RQK....IKP..HPGSLYRLKM.S.HVKRISL.QSAV....AERCP.TLYSR--.-.....EQLYRYGIVKN.....HIGVSSENALS..FQFHCSNYFTK....EL.LL.........SGNGVQLADGG.....WL.IPT.EQGN..A.GK.EEIYRAFCDTP...GVDPKLISAEWVHNHYRWIVWKLAA..M..EV.RFPK...T...F...AC...R.CLTPERVLLQLKYRYDVEIDKS....................
Q4P9L3_USTMA/622-674               .............................................................................................nadm--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-----------...---------PWVQNHWTLILWKLAA..M..VR.LEPS...S...A...SN...R.-WSWNELIRQLLYRYEREVN--la..................
G7J9J4_MEDTR/551-722               iglhatvssfkkprisnisasggqdvqyfsndlaqlssgasgfkrkvstrypfhhprmyikdyfavppleqkvnfpnparqvtscnagayifhdgsd--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.-SND..M.GA.EAFI-HLLTQH...GASLRFASKEWVLNHYKWIVWKLAC..Y..ER.CYPA...R...C...AG...K.FLTVSNVLEELKYRYEREVN--hg..................
H9IBY3_ATTCE/846-1032              ................................................................................ilqdrltaaleqeaiit--------........-------.--AK.RRRAQ..SEG....SKQ..SMGHLYRYKQiN.SNARLSM.RQIG....GDAPP.IPCSY--.-.....QELIDRRISPR.....ILEITAATAAT..YKFRCSDFYGD...dVA.HR.........NVRGIEMEDSV.....RL.ILD.ENGY..T.GI.WEFLRAFLASP...GVDPNLVPARWVENHYRWIVWKLAS..M..DR.M---...-...-...--...K.ALTPSYVMAQLKYRYDREIDRS....................
F1P3B2_CHICK/2425-2613             .................................................................................................NMMANLHC........---ARDL.QEMR.IKKKY..RQN....ISP..QPGSLYVTKT.S.ARNRISL.KTAV....EEETP.SFHST--.-.....EKLYTYGVSKH.....CIQVNSTNAES..FQFLIEEFFSK....EY.LL.........AGNGIQLADGG.....WL.IPT.DEGK..A.GK.KEFYRALCDTP...GVDPKLITEAWVYNHYRWIVWKLAA..M..EV.CFPH...K...F...AN...R.CLTPETVLLQLKYRYDLEIDKS....................
I1HCA6_BRADI/863-964               ............................................................................................cfnls--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..----------K....EH.LT.........DE--VKLMDAKr...aEK.YTF.DSLG..T.GA.EEFQKMLLA-C...GASSTYATKEWVSNHYKWIVWKLAS..L..ER.CYPT...K...A...AG...K.FLTVANVFEELKYRYDREVNN-g...................
E1C2I8_CHICK/2428-2616             .................................................................................................NMMANLHC........---ARDL.QEMR.IKKKY..RQN....ISP..QPGSLYVTKT.S.ARNRISL.KTAV....EEETP.SFHST--.-.....EKLYTYGVSKH.....CIQVNSTNAES..FQFLIEEFFSK....EY.LL.........AGNGIQLADGG.....WL.IPT.DEGK..A.GK.KEFYRALCDTP...GVDPKLITEAWVYNHYRWIVWKLAA..M..EV.CFPH...K...F...AN...R.CLTPETVLLQLKYRYDLEIDKS....................
BRCA2_FELCA/2423-2611              .................................................................................................DLIASLQN........---ARDI.QDMR.IREKR..KQH....IFP..QPGSLFLAKT.S.TVPRISL.RVAV....EGRVP.SACSH--.-.....KQLYMYGVSKH.....CVKINSKNAES..FQFHTQDYFGK....EV.QW.........AKEGIQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPNLISRIWVYNHYRWIIWKLAA..M..EF.AFPK...E...F...AN...R.CLSPERVLLQLKYRYDMEIDRS....................
B8PHD4_POSPM/629-698               ......................................................................................daaltelhemg--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-----------...---CSLAKKEWVENHWRMILWKLAG..M..AC.LQPE...R...E...SNpetR.RWCWGEVMKQLLYRYERELN--sg..................
BRCA2_HUMAN/2479-2667              .................................................................................................DLITSLQN........---ARDI.QDMR.IKKKQ..RQR....VFP..QPGSLYLAKT.S.TLPRISL.KAAV....GGQVP.SACSH--.-.....KQLYTYGVSKH.....CIKINSKNAES..FQFHTEDYFGK....ES.LW.........TGKGIQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISRIWVYNHYRWIIWKLAA..M..EC.AFPK...E...F...AN...R.CLSPERVLLQLKYRYDTEIDRS....................
E2A3F8_CAMFO/1109-1301             ....................................................................................arilqdrltaald--------........-------.QEKI.ITAKR..RHG....SKQ..SIGHLYRYKQvN.SNARLSL.REIG....NGAPP.VPFSY--.-.....QELINRQISPN.....ILAITAATATS..YTFRCSDFYGA....EVaRT.........NVRGIPMEDDA.....RL.ILD.ENGY..V.GI.WEFLRAFLASP...GVDPNLVPARWVENHYRWIVWKLAS..M..DRmKFGS...A...E...LP...R.ALTPSRVMAQLKYRYDREIDQ-f...................
G1PNI9_MYOLU/2428-2616             .................................................................................................DCIANLQN........---ARDV.QDMR.IKKKH..GQQ....IFP..QPGSLYLAKT.S.TVPRISL.KVAV....EGQVP.SACSH--.-.....KQLYMYGVSKH.....CLTINSKNAES..FQFHTQDYFGK....EA.SW.........AGKGTQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISRGWVYNHYRWIIWKLAA..M..EF.AFPK...E...F...AN...R.CLSPERVLLQLKYRYDMEIDRS....................
Q4RRH3_TETNG/1-195                 .................................................................................................DLFQHLHN........VELARDM.QGMR.IRKKK..RQT....ILP..LPGSLFLKKS.S.GVTRIPL.KSAV....NGKPP.ALLTSFV.V.....FQLYGLGVPLN.....VLEITSETAGS..FRFSLQQFVKL....ES.LT.........DKGGIQLADGG.....WL.IPR.NDGT..A.GK.EEFYRALCDTT...GVDPKLISEEWVYNHYRWIVWKQAS..M..ER.SFPE...Q...L...GS...L.CLTPEQVLLQLKYRYDIEVDQS....................
B7PB26_IXOSC/840-978               ..................................................................................gqsrlgkselyrdcf--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.I.....FQLTAFGVSGV.....TASVNSISAAN..FEFSTPPP---....EA.L-.........----IILGDGA.....TVqLSP.GQSR..L.GK.SELYSAFLGVP...GVDSSLISREWFDNHYRWIVWKLAS..L..EQ.HGPH...V...F...AG...R.SLTPDNVMLQMKYRYDVEIDHS....................
Q16FF5_AEDAE/925-1124              .................................................................................................DVVAKLNSd.....ggLKVAPHI.AEAR.KLSMQ..RQQ....SYI..ENKPLEERRP.R.LTEFISK.KQMR....GRSTL.RQFVENR.N.....PSAEPCSVPEK.....LRDVNADNAMN..FKFDMIEFYTK...tEC.LE.........NVDGIVLGDSNt...tTL.FFN.ERCQ..A.GL.PEFKLAFLASP...GIDPALVPAGWIENCWVWTIIKLTS..M..ER.NLPD...C...F...HG...-.ITTLENMFNQIMYRYHLEIDSA....................
B8ADF3_ORYSI/850-946               ...........................................................................ltedvtdevklmdakkaekykf--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.-KTD..T.GA.EEFQEMLLA-C...GASLTYATKEWVSNHYKWIVWKLAS..L..ER.CYPT...R...A...AG...K.FLKVGNVLEELKYRYDREVNN-g...................
Q8QFV6_CHICK/2426-2614             .................................................................................................NMMANLHC........---ARDL.QEMR.IKKKY..RQN....ISP..QPGSLYVTKT.S.ARNRISL.KTAV....EEETP.SFHST--.-.....EKLYTYGVSKH.....CIQVNSTNAES..FQFLIEEFFSK....EY.LL.........AGNGIQLADGG.....WL.IPT.DEGK..A.GK.KEFYRALCDTP...GVDPKLITEAWVYNHYRWIVWKLAA..M..EV.CFPH...K...F...AN...R.CLTPETVLLQLKYRYDLEIDKS....................
F4JGU5_ARATH/564-616               .......................................................................................kvcdrsfeac--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-----------...----------------MWIVWKLAC..Y..DI.YYPA...K...C...RG...N.FLTITNVLEELKYRYEREVN--hg..................
I1NKI6_ORYGL/863-970               ..................................................................fftlltynscdqtedvtdevklmdakkaeky--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.--K.FKTD..T.GA.EEFQKMLLA-C...GASLTYTTKEWVSNHYKWIVWKLAS..L..ER.CYPT...R...A...AG...K.FLKVGNVLEELKYRYDREVNN-g...................
F7EV30_MONDO/2441-2631             ..............................................................................................hle-M---IEN........LQHAREM.QDMR.IKKKQ..TQK....IHP..QAGSLYLRKT.S.TLPRSSL.RVVV....EGKVP.STYSS--.-.....KQLYMYGITKQ.....CLRINSKNSES..FKFHSEDYFSK....EH.LL.........DGNGIQLADGG.....WL.IPT.DEGK..L.GK.EEFYRALCDTP...GVDPKLITKTWVYNHYRWIIWKLAA..M..EF.TFPK...E...F...AS...R.CLTPEWVLLQLKYRYDIEIDES....................
F1R8E8_DANRE/2021-2212             .................................................................................................DMIALQES........LQLARDM.QDMR.LRKKK..RQT....IRP..VPGSLYLAKT.S.GVSRKSL.RDAV....GCTCP.SQYTQ--.-.....DELSQHGVHHK.....VLEITSENAES..FRFDCSDYFTC....EH.LM.........ESGALQLADGG.....WL.VPD.SKGT..V.GK.EEFFSALCDTP...GVDPKLISDVWVFNHYRWIIWKRAS..M..ER.TFPN...L...I...GG...L.CLTPEQVLLQLKFRYDVEVDHS....................
H2NJK5_PONAB/2476-2664             .................................................................................................DLITSLQN........---ARDI.QDMR.IKKKQ..RQR....IFP..QPGSLYLAKT.S.TLPRISL.KAAV....GGQVP.SACSH--.-.....KQLYTYGVSKH.....CIKINSKNAES..FQFHTEDYFGK....EN.LW.........TGKGVQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISRIWVYNHYRWIIWKLAA..M..EC.AFPK...E...F...AN...R.CLSPERVLLQLKYRYDMEIDRS....................
Q3TN53_MOUSE/251-439               .................................................................................................DLMSSLQS........---ARDL.QDMR.IKNKE..RRH....LRL..QPGSLYLTKS.S.TLPRISL.QAAV....GDRAP.SACSP--.-.....KQLYIYGVSKE.....CINVNSKNAEY..FQFDIQDHFGK....ED.LC.........AGKGFQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISSIWVANNYRWIVWKLAA..M..EF.AFPK...E...F...AN...R.CLNPERVLLQLKYRYDVEIDNS....................
G7NJX0_MACMU/2483-2671             .................................................................................................DLITSLQN........---ARDI.QDMR.IKKKQ..RQR....IFP..QPGSLYLAKT.S.TLPRISL.KAAV....GGQVP.SACSH--.-.....KQLYMYGVSKH.....CIKINSKNAES..FQFYTQDYFGK....ES.LW.........AGKGIQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISRIWVYNHYRWIIWKLAA..M..EC.AFPK...E...F...AN...R.CLSPERVLLQLKYRYDMEIDRS....................
G7E6Z2_MIXOS/612-678               .....................................................................................qalqdlltrgmt--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-----------...-----MLDQPWVTNHWSQILWKLSS..QchHT.AAPS...V...M...LS...-.RWSYEHVMHQLGIRYDIEINQA....................
D6WEG4_TRICA/387-566               .........................................................................................nldtwlqn--------........------L.QNERkILEVK..LKV....IIE..KEKVLNLQKE.I.LENRVQR.QSGIlftrKENSE.RVLLK-H.G.....INIDSCRVS--.....-SEINSENSPN..VHL--KYVWVW....EK.LP.........M---IKTLDGA.....CV.VPN.VDNF..V.GL.SEIEVAFNTIP...GVETKLIPNGWVQNHFRWIVWKLAC..Y..E-.----...N...F...NF...D.CLTVENIMQQLKYRYDREIDRA....................
B5YME7_THAPS/1-58                  .................................................................................................--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-----------...GCDDSLFSDKWIGNHYRWIVWKLAA..M..ER.RFPH...H...L...GG...H.YLTYERVLKQMKGRYDKEL---rn..................
F4PXC2_DICFS/390-449               ............................................................................................kdssf--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-----------...----KCVTDDWVRNHYGWIVWKLAA..M..ER.AFPD...I...F...GG...K.HLTLYNVMTQLKKRCTKE----lvqc................
F7E9I9_XENTR/2244-2435             .................................................................................................DILQMTSN........LRCSKDL.QEMR.IRKKL..RQK....IKP..HPGSLYRLKM.S.HVKRISL.QSAV....AERCP.TLYSR--.-.....EQLYRYGIVKN.....HIGVSSENALS..FQFHCSNYFTK....EL.LL.........SGNGVQLADGG.....WL.IPT.EQGN..A.GK.EEIYRAFCDTP...GVDPKLISAEWVHNHYRWIVWKLAA..M..EV.RFPK...T...F...AC...R.CLTPERVLLQLKYRYDVEIDKS....................
C1N0K9_MICPC/84-181                ...............................................................................ldaaaramtadtaigyrv--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.-SS.DDGA..TlTT.ADFRREMLDA-...GCKAHLLSKEYVSNACRWVVWQQAC..V..AR.AFPE...H...L...GA...RgALSKRAVTQRLLYRYEREL---ira.................
D8LCN1_ECTSI/2812-2890             .......................................................................................svtaaaeaap--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.RSFREELLR-S...GRDGQLATPIWVQNHTRWIVWKLAA..M..ER.RFPE...H...F...PG...G.YLTAGRLARQLQYRYGVELDRA....................
G7PVZ4_MACFA/2483-2671             .................................................................................................DLITSLQN........---ARDI.QDMR.IKKKQ..RQR....IFP..QPGSLYLAKT.S.TLPRISL.KAAV....GGQVP.SACSH--.-.....KQLYMYGVSKH.....CIKINSKNAES..FQFYTQDYFGK....ES.LW.........AGKGIQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISRIWVYNHYRWIIWKLAA..M..EC.AFPK...E...F...AN...R.CLSPERVLLQLKYRYDMEIDRS....................
H0X313_OTOGA/2468-2656             .................................................................................................DLITSLQN........---ARDT.QDMR.IKKKQ..RHH....ISP..QPGSLYLAKT.S.SLPRISL.KAAV....GGRVP.SACSH--.-.....KQLYMYGVSKH.....CIKINSKNAES..FQFHIQDYFGK....EY.LW.........AGKGIQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISRVWVYNHYRWIIWKLAA..M..EF.AFPK...E...F...AN...R.CLSPERVLLQLKYRYDLEIDRS....................
Q6PB43_MOUSE/251-439               .................................................................................................DLMSSLQS........---ARDL.QDMR.IKNKE..RRH....LRL..QPGSLYLTKS.S.TLPRISL.QAAV....GDRAP.SACSP--.-.....KQLYIYGVSKE.....CINVNSKNAEY..FQFDIQDHFGK....ED.LC.........AGKGFQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISSIWVANHYRWIVWKLAA..M..EF.AFPK...E...F...AN...R.CLNPERVLLQLKYRYDVEIDNS....................
F6TTA8_HORSE/2451-2639             .................................................................................................NLITNLQN........---ARDT.QDMR.IKKKQ..KQH....IFP..QPGSLYLAKT.S.SVPRISL.KAAV....GGHVP.SAYSH--.-.....KQLYMFGVSKH.....CVKINSKNAGS..FQFLTQDYFGK....EA.LL.........AGKGIQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISRVWVYNHYRWIVWKLAA..M..EF.AFPK...E...F...AN...R.CLTPERVLLQLNQLYDIEIDRS....................
D7M6H1_ARALL/540-621               .........................................................................................vfcdesss--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.--NK..V.GA.ETFLL-MLAES...GASLQHASRKWVTNHYRWIVWKLAC..Y..DI.YYPA...K...C...RG...N.FLTITNVLEELKYRYEREVN--hg..................
Q8NJ74_USTMD/622-674               .............................................................................................nadm--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-----------...---------PWVQNHWTLILWKLAA..M..VR.LEPS...S...A...SN...R.-WSWNELIRQLLYRYEREVN--la..................
F6RE00_XENTR/2268-2459             .................................................................................................DILQMTSN........LRCSKDL.QEMR.IRKKL..RQK....IKP..HPGSLYRLKM.S.HVKRISL.QSAV....AERCP.TLYSR--.-.....EQLYRYGIVKN.....HIGVSSENALS..FQFHCSNYFTK....EL.LL.........SGNGVQLADGG.....WL.IPT.EQGN..A.GK.EEIYRAFCDTP...GVDPKLISAEWVHNHYRWIVWKLAA..M..EV.RFPK...T...F...AC...R.CLTPERVLLQLKYRYDVEIDKS....................
G3PC75_GASAC/1-180                 ................................................................................................l------PN........VELAQDM.QDMR.IRKKK..RQT....IRP..LPGSLFLTKT.S.GVTRIPL.KAAL....-----.VFL----.-.....LQLYRHGVHQH.....VCEISSETAES..FRFNLKQFIKR....EA.LL.........DGGGVQLADGG.....WL.IPS.KDGT..A.GK.EEFYRALCDTP...GVDPKLISDGWVDNHYRWVVWKQAS..M..ER.SFPE...T...M...GG...L.CLTPEQVLLQLKYRYDVEVDHS....................
G5B7X6_HETGA/2399-2527             .................................................................................................DLMTSLQK........---AREI.QDIR.IKKKE..RQH....IFP..QPGSLYLAKT.S.TLPRISL.KAAV....GGRVP.SACSH--.-.....KQLYMYGISKH.....CMKINSKNAGS..FQFHTQDYFGK....ED.LQ.........AGKGIQLADGG.....WL.IPT.NDGK..A.GK.EEFYR------...-------------------------..-..--.----...-...-...--...-.----------------------ydmev...............
D3BKW3_POLPA/488-569               ..........................................................................................dsktmrq--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.--KK..I.GL.SEISTMILREN...LIEPRLITDEWMDNHYGWIVWKLAS..M..EK.AFPQ...H...F...GG...R.HLTLQRVLSQLKDRINREL---iqa.................
Q7Y1C4_ARATH/535-625               ................................................................................ikssnadkyvfcdesss--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.--NK..V.GA.ETFLQ-MLAES...GASLQHASRKWVTNHYRWIVWKLAC..Y..DI.YYPA...K...C...RG...N.FLTITNVLEELKYRYEREVN--hg..................
E0W1Z3_PEDHC/1116-1297             ...........................................................seeihldvkeerylarvsqeqriknkekvtpirgtltv--------........-------.----.-----..---....---..----------.-.------K.KSEK....NRPKL.AE----M.V.....KHLVGENYYKK.....NSFIKPEEALN..YKFSTESNTHG....FS.-V.........NSVNVELDDGF.....QI.IPDdNRHE..A.GV.EEFKRGFLSGP...GIQPNLIPEGWFENHYKWIVWKLSH..Y..EK.AFPE...Y...F...KG...K.ILSPNHVMQQLKYRYDREIDK-c...................
Q54BU8_DICDI/695-776               .......................................................................................vkdigkskti--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.GV.ADLYIYLTKIN...QSNAALVSQEWVSNHYGWIVWKLAS..M..ER.SFPL...E...F...GG...K.YLKLQRVVNQLKQRIEIEINQA....................
E4XD02_OIKDI/857-1037              ...........................................................................ldnrimsaeeierlnllvfkie--------........-------.----.-----..---....---..----------.-.--NNISK.KTRT....QDRYG.DRMNRKK.Y.....HQEKGQTVRLKdlapkLNAQTQSNAGHagHNFNLFDHYTK....EA.LL.........H--GTKAPDGG.....IY.SCA.ADGT..F.AT.KHIRRTLLSSSinsSFHPKL-TVKWVENHVKLVKQKLAG..Y..HN.YLDH...Q...L...TG...L.IFDPDELLLQLRLRADVE----fidg................
F1N924_CHICK/2422-2610             .................................................................................................NMMANLHC........---ARDL.QEMR.IKKKY..RQN....ISP..QPGSLYVTKT.S.ARNRISL.KTAV....EEETP.SFHST--.-.....EKLYTYGVSKH.....CIQVNSTNAES..FQFLIEEFFSK....EY.LL.........AGNGIQLADGG.....WL.IPT.DEGK..A.GK.KEFYRALCDTP...GVDPKLITEAWVYNHYRWIVWKLAA..M..EV.CFPH...K...F...AN...R.CLTPETVLLQLKYRYDLEIDKS....................
F4WV33_ACREC/843-1039              ....................................................................................tkvlqdrlaaale--------........-------.QEAI.ITAKR..RRAqsegSKQ..SMGHLYRYKQiN.SNARLSM.RQIG....GGAPP.IPCSY--.-.....QELIDRRISPR.....ILEITAATAAT..YKFRCSDFYGD...dVA.HR.........NVRGIEMEDDV.....RL.ILD.ENGY..A.GI.WEFLRAFLASS...GVDPNLIPARWVENHYRWIVWKLAS..M..DRmKFGS...V...K...LP...R.ALTPSYVMAQLKYRYDREIDRS....................
B7ZVU5_DANRE/2021-2212             .................................................................................................DMIALLES........LQLARDM.QDMR.LRKKK..RQT....IRP..VPGSLYLAKT.S.GVSRKSL.RDAV....GCKCP.SQYTQ--.-.....DELSQHGVHHK.....VLEITSENAES..FRFDCSDYFKC....EH.LM.........ESGALQLADGG.....WL.VPD.SKGT..V.GK.EEFFSALCDTP...GVDPKLISDVWVFNHYRWIIWKRAS..M..ER.TFPN...L...I...GG...L.CLTPEQVLLQLKFRYDVEVDHS....................
A8QLH9_DANRE/2021-2212             .................................................................................................DMIALQES........LQLARDM.QDMR.LRKKK..RQT....IRP..VPGSLYLAKT.S.GVSRKSL.RDAV....GCTCP.SQYTQ--.-.....DELSQHGVHHK.....VLEITSENAES..FRFDCSDYFTC....EH.LM.........ESGALQLADGG.....WL.VPD.SKGT..V.GK.EEFFSALCGTP...GVDPKLISDVWVFNHYRWIIWKRAS..M..ER.TFPY...L...I...GG...L.CLTPEQVLLQLKFRYDVEVDHS....................
Q8UW79_CHICK/2425-2613             .................................................................................................NMMANLHC........---ARDL.QEMR.IKKKY..RQN....ISP..QPGSLYVTKT.S.ARNRISL.KTAV....EEETP.SFHST--.-.....EKLYTYGVSKH.....CIQVNSTNAES..FQFLIEEFFSK....EY.LL.........AGNGIHLADGG.....WL.IPT.DEGK..A.GK.KEFYRALCDTP...GVDPKLITEAWVYNHYRWIVWKLAA..M..EV.CFPH...K...F...AN...R.CLTPETVLLQLKYRYDLEIDKS....................
BRCA2_RAT/2409-2597                .................................................................................................DLMSSLQN........---ARDL.QDIR.IKNKE..RHH....LCP..QPGSLYLTKS.S.TLPRISL.QAAV....GDSVP.SACSP--.-.....KQLYMYGVSKA.....CISVNSKNAEY..FQFAIEDHFGK....EA.LC.........AGKGFRLADGG.....WL.IPS.DDGK..A.GK.EEFYRALCDTP...GVDPKLISSVWVSNHYRWIVWKLAA..M..EF.AFPK...E...F...AN...R.CLNPERVLLQLKYRYDVEIDNS....................
#=GR BRCA2_RAT/2409-2597     SS    .................................................................................................THHHHHHH........---HHHH.HHHH.HHHHT..TS-....---..---TTTTTTT.S.-S--EEH.HHHH....TS---.----S--.-.....SSHHHHT--TT.....GGG--TTTTTT..--B-HHHHH-T....TT.SS.........STT-EEEGGGE.....EE.---.TTS-..B.-H.HHHHHHHHTST...T--GGG--HHHHHHHHHHHHHHHHH..H..HH.HSTT...T...T...TT...T.SSSHHHHHHHHHHHHHHHTTS-....................
A7SNN6_NEMVE/1-134                 .............................................................................................slym--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....SQLDNLGVSGE.....VQAVTSANAGS..FRFDGRAFCSE....HA.RA.........TEGGIRTEDGG.....LV.RLG.SDGR..V.GL.EEIEAAFLGTP...GVDPSLVCTGWVANHFRWIVWKLAA..L..EV.SFPQ...C...F...AG...R.CLTPDWVMCQLKYRYDLEIDRS....................
H3AGP4_LATCH/229-424               .........................................................................................nifqslee-MTANLQC........---ARDL.QEMR.LRKKQ..RQN....IRP..QPGSLYLAKT.S.GVARVSL.KAAT....GNQCP.SSYST--.-.....EQLYVHGVGKS.....TLKVRSENAES..FQFSCSDYFGK....DV.LL.........AGNGLKLADGG.....WL.IPS.DKGM..V.GK.EEFYRALCDTP...GVAPKLISESWVYNHYRWIVWKLAA..M..EA.AFPK...E...F...GN...R.CLTPERVLLQLKYRYDIEVDK-c...................
B9IB91_POPTR/544-657               ..................................................................keyfgghlsdkrlseyftdqvrqiksnnadk--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....YM.FCD.ESGRdsI.GA.EAFYDMLLQS-...GALSQYASKEWVINHYKWIVWKLAC..Y..ER.CCPE...K...S...AA...K.FLSVSNVLEELKYRYEREVN--hg..................
E1B8X8_BOVIN/2422-2611             .............................................................................................nysi---TNLQN........---ARDI.QDMR.IRKKQ..RQC....IFP..QPGSLYLAKT.S.TMPRIPL.REAV....EGRIP.SACSH--.-.....KQLYMYGVSKH.....CVKINSKNAEA..FQFHTQDYFGK....ES.LW.........TGKGIQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISRVWVYNHYRWIIWKLAA..M..EF.AFPK...K...F...AN...R.CLNPERVLLQLKYRYDVEIDRS....................
Q7Y1C5_ARATH/528-621               .............................................................................vrrikssnadkyvfcdesss--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.--NK..V.GA.ETFLQ-MLAES...GASLQHASRKWVTNHYRWIVWKLAC..Y..DI.YYPA...K...C...RG...N.FLTITNVLEELKYRYEREVN--hg..................
O81303_ARATH/570-620               .........................................................................................cdrsfeac--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-----------...----------------MWIVWKLAC..Y..DI.YYPA...K...C...RG...N.FLTITNVLEELKYRYEREVN--hg..................
E7A288_SPORE/613-678               ...................................................................................eqalneleargcsa--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-----------...------VEKAWVQNHWTLILWKLAA..M..VR.FEPS...S...A...PE...R.-WSWNEVIRQLLYRYEREVHR-a...................
Q5VQI6_ORYSJ/336-391               .............................................................................................krpr--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-----------...-------SSRWVSNHYKWIVWKLAS..L..ER.CYPT...R...A...AG...K.FLKVGNVLEELKYRYDREVNN-g...................
I1LXQ3_SOYBN/412-530               ...........................................................qyprmhikdffvvpplqekahfpnlsrqvtsvnaekyv--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.FYE.RSGD..N.GMgAEAFVHLLAHH...GASMHFATKEWVTNHYKWIVWKLAC..Y..ER.YYPA...S...S...AG...K.FLTVTNVLEELKYRYEREVN--hg..................
Q5KDQ9_CRYNJ/5-61                  ..............................................................................................cgc--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-----------...----ALATAEWIKNHWAQILWKLAG..E..VQ.ARPD...L...L...TE...-.KWSWEEVISQLKYRYERE----fgva................
I0YVH7_9CHLO/998-1101              ..................................................................savseavleldsttatdltltafegvgkdge--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.---R..L.GH.AEF-AALLHAA...GAEQQYASVAWVTNHFRWVVWKLAC..Y..ER.QFPA...H...L...AG...R.MLTPSLVLDQLKYRYEREF---gqg.................
Q8VHD0_MOUSE/2400-2588             .................................................................................................DLMSSLQS........---ARDL.QDMR.IKNKE..RRH....LRL..QPGSLYLTKS.S.TLPRISL.QAAV....GDRAP.SACSP--.-.....KQLYIYGVSKE.....CINVNSKNAEY..FQFDIQDHFGK....ED.LC.........AGKGFQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISSIWVANHYRWIVWKLAA..M..EF.AFPK...E...F...AN...R.CLNPERVLLQLKYRYDVEIDNS....................
B9ET11_ORYSJ/846-934               .............................................................................edvtdevklmdakkaekykf--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.-KTD..T.GA.EEFQKMLLA-C...GASLTYTTKEWVSNHYKWIVWKLAS..L..ER.CYPT...R...A...AG...K.FLKVGNVLEELKY---------sml.................
G3UEA2_LOXAF/286-474               .................................................................................................DLITNLQN........---ARDR.QDTR.IKMKQ..RQR....VCP..QPGSLYLAKT.S.TVPRLSL.KMAV....GGRAP.STCSP--.-.....KQLYMYGVPEH.....CIKINSKTAES..FRFHAQDYFGK....EA.LW.........AGKGIQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISRDWVYNHYRWILWKLAA..M..EF.SFPK...E...F...AN...R.CLTPERVLLQLKYRYDVEVDRS....................
G1TCK4_RABIT/2461-2649             .................................................................................................DLITSLQN........---ARDI.QDMR.IKKKQ..RQR....VFP..QPGSLYLAKT.S.TLPRISL.KTAV....GSQIP.SACSH--.-.....KQLYMYGVSKH.....CIKINSKNAES..FQFHAQDYFGK....ED.LW.........ARKGIRLADGG.....WL.VPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISGVWVYNHYRWIIWKLAA..M..EF.AFPK...E...F...AN...R.CLTPERVLLQLKYRYDIEIDR-c...................
B8P1I5_POSPM/631-700               ......................................................................................daaltelhemg--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-----------...---CSLAKKEWVENHWRMILWKLAG..M..AC.LQPE...R...E...SNpetR.RWCWAEVMKQLLYRYERELN--sg..................
G0SX58_RHOG2/679-773               ................................................................davldmdstsgasytfpcgrgvadafstlqalv--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-------CERM...PQEKDLVTLPWVKNHWSLILWKLAS..Y..VR.SRPD...L...L...DE...R.-WSFGRVMDQLRYRYEREVNRA....................
A5A3F7_STRPU/2664-2850             ..........................................................................................fvarwae--------........---ARRA.QQQR.IDAKR..KKV....IKP..ELGSLWRSRK.-.EQDRISL.GEFV....NHQYP.CSMSD--.-.....SELFGHGILSS.....TLSVRPSNAEG..YEFAGEDHFSP....SC.LE.........SDRGIPLDDGG.....RL.VLS.PNGL..A.GK.KEFYSALLDTP...GVDPKLLKEEWVFNHYKWIIWKAAA..M..EV.AYPL...Q...L...GG...R.FLTPNWVLLQLKYRYDREIDHS....................
F4NS03_BATDJ/1816-1883             .........................................................................................saarssii--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.---------AA...GANQKLANEAWVQNHYSLILWKLAS..L..VR.RFPF...E...Y...RT...-.YWSFDTVVQQLKYRYEMEINK-v...................
F1Q0X3_CANFA/2498-2686             .................................................................................................DLITNLQN........---ARDI.QDMR.IKKKQ..RQH....IFP..QPGSLYLAKT.S.TLPRISL.REAV....EGRVP.SACSH--.-.....KQLYMYGVSKH.....CVKINSKNAES..FQFHAQDYFGK....EG.LW.........SGEGIQLADGG.....WL.IPS.NDGK..I.GK.EEFYRALCDTP...GVDPNCISRVWVYNHYRWIIWKLAA..M..EF.AFPK...E...F...AN...R.CLSPERVLLQLKYRYDVEIDKS....................
E9CAL7_CAPO3/979-1109              .............................................................................................pptk--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....--AITAANAST..FRFSAPEHMDL....AD.VAggflpltvsAYSGES----GathnvSL.QLG.TDGC..A.GA.AEFELALRQVP...GVKLSLIAGEWVANHFRWIVWKLAS..Q..DT.RLHH...V...S...RQ...R.CLTPQRVMTQLRARYEYEVNH-a...................
I0IV83_CANFA/2497-2685             .................................................................................................DLITNLQN........---ARDI.QDMR.IKKKQ..RQH....IFP..QPGSLYLAKT.S.TLPRISL.REAV....EGRVP.SACSH--.-.....KQLYMYGVSKH.....CVKINSKNAES..FQFHAQDYFGK....EG.LW.........SGEGIQLADGG.....WL.IPS.NDGK..I.GK.EEFYRALCDTP...GVDPNCISRVWVYNHYRWIIWKLAA..M..EF.AFPK...E...F...AN...R.CLSPERVLLQLKYRYDVEIDKS....................
I0IV85_CANFA/2497-2685             .................................................................................................DLITNLQN........---ARDI.QDMR.IKKKQ..RQH....IFP..QPGSLYLAKT.S.TLPRISL.REAV....EGRVP.SACSH--.-.....KQLYMYGVSKH.....CVKINSKNAES..FQFHAQDYFGK....EG.LW.........SGEGIQLADGG.....WL.IPS.NDGK..I.GK.EEFYRALCDTP...GVDPNCISRVWVYNHYRWIIWKLAA..M..EF.AFPK...E...F...AN...R.CLSPERVLLQLKYRYDVEIDKS....................
H0ZNF4_TAEGU/2394-2584             ..............................................................................................mar-MVTNLRC........---ARDL.QEMR.IKKKC..RQN....IRS..QPGSLYVIKT.S.ASNRISL.KNAV....EEKSP.SFYST--.-.....EELYTYGVSKQ.....CIQVNSTNAES..FQFLIKDFFSK....EY.LL.........AGNGMHLADGG.....WL.IPT.DEGK..A.GK.KEFYRALCDTP...GVDPNLITEAWVYNHYRWIVWKLAA..M..EV.SFPR...E...F...AN...R.CLTPEMVLLQLKYRYDLEVDKS....................
F7BTV7_CALJA/2472-2660             .................................................................................................DLITSLQN........---ARDI.QDMR.IKKKQ..RQC....IFP..QPGSLYLTKT.S.TLPRISL.KAAV....GSQFP.SACSH--.-.....KQLYMYGVSKH.....YVKINSKNAES..FQFHTQDYFGK....ES.LW.........AGKGIQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISRIWVYNHYRWIIWKLAA..M..EF.AFPK...E...F...AN...R.CLSPERVLLQLKYRYDMEIDKS....................
G3SQY0_LOXAF/2423-2611             .................................................................................................NLITNLQN........---ARDR.QDTR.IKMKQ..RQR....VCP..QPGSLYLAKT.S.TVPRLSL.KMAV....GGRAP.STCSP--.-.....KQLYMYGVPEH.....CIKINSKTAES..FRFHAQDYFGK....EA.LW.........AGKGIQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISRDWVYNHYRWILWKLAA..M..EF.SFPK...E...F...AN...R.CLTPERVLLQLKYRYDVEVDRS....................
Q9M013_ARATH/568-620               .......................................................................................kvcdcsfeac--------........-------.----.-----..---....---..----------.-.-------.----....-----.-------.-.....-----------.....-----------..-----------....--.--.........-----------.....--.---.----..-.--.-----------...----------------MWIVWKLAC..Y..DI.YYPA...K...C...RG...N.FLTITNVLEELKYRYEREVN--hg..................
F6TLV1_HORSE/2483-2671             .................................................................................................DLITNLQN........---ARDT.QDMR.IKKKQ..KQH....IFP..QPGSLYLAKT.S.SVPRISL.KAAV....GGHVP.SAYSH--.-.....KQLYMFGVSKH.....CVKINSKNAGS..FQFLTQDYFGK....EA.LL.........AGKGIQLADGG.....WL.IPS.NDGK..A.GK.EEFYRALCDTP...GVDPKLISRVWVYNHYRWIVWKLAA..M..EF.AFPK...E...F...AN...R.CLTPERVLLQLNQLYDIEIDRS....................
A4ZZ89_MONDO/2462-2652             ..............................................................................................hle-M---IEN........LQHAREM.QDMR.IKKKQ..TQK....IHP..QAGSLYLRKT.S.TLPRSSL.RVVV....EGKVP.STYSS--.-.....KQLYMYGITKQ.....CLKINSKNSES..FKFHSEDYFSK....EH.LL.........DGNGIQLADGG.....WL.IPT.DEGK..L.GK.EEFYRALCDTP...GVDPKLITKTWVYNHYRWIIWKLAA..M..EF.TFPK...E...F...AS...R.CLTPEWVLLQLKYRYDIEIDES....................
D2UYY4_NAEGR/598-798               ..............................................tpikskesfeeakkreserrsastsssssisitkktsdttpitapswvpvk--------........-------.----.-----..---....---..------HHKS.D.SKEEVHV.KRRI....--NTL.GICEQLP.I.....EKIKREGVSQY.....SITMTSISAKT..FKFNLNDFKVS...nEM.IE.........---AIVSLNGN.....KR.VV-.---N..F.GS.EEYERLLV-HF...GAKTSVVKTDWVENHYRWIVWKLAS..L..DR.TFPN...D...K...SF...P.FLTPEKVLGQLIYRYNVEF---ckg.................
#=GC SS_cons                       .................................................................................................THCHHHHH........---HHHH.HHHH.HHHHC..TS-....---..---CCCCCCT.S.-S--EEC.CHHH....TS-S-.---TT--.-.....SSHCCCT--TT.....CCC--TTTTTT..--B-CHHHHTT....TT.TT.........STT-EEECCCE.....EE.---.TTS-..B.-H.HHHHHHHHCST...T--CCC--HHHHHHHHHHHHHHHHH..C..CC.CSTT...T...T...TT...T.SSSHHHHHHHHHHHHHHHTTS-....................
#=GC seq_cons                      ....................................................................................................................................................................h.t...............h............ph..htl..t.....h.tlpstsu....apF...paht.....t..h..........t.tuh.htDus.....hl.l.s.ppGp..s.Gt.cEFhcAlhsss...GVDPpLloctWVhNHYRWIlWKLAu..M..Eh.sFPc...c...h...us...+.sLoP-pVLhQLKYRYDhElDp.....................
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