GenomeNet

Database: Pfam
Entry: BSP_II
LinkDB: BSP_II
Original site: BSP_II 
#=GF ID   BSP_II
#=GF AC   PF05432.8
#=GF DE   Bone sialoprotein II (BSP-II)
#=GF AU   Moxon SJ
#=GF SE   Pfam-B_12103 (release 8.0)
#=GF GA   25.10 25.10;
#=GF TC   25.40 25.60;
#=GF NC   23.70 23.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   8061918
#=GF RT   Characterization of the human bone sialoprotein (BSP) gene and
#=GF RT   its promoter sequence. 
#=GF RA   Kim RH, Shapiro HS, Li JJ, Wrana JL, Sodek J; 
#=GF RL   Matrix Biol 1994;14:31-40.
#=GF RN   [2]
#=GF RM   10785518
#=GF RT   Expression of bone sialoprotein in mineralized tissues of tooth
#=GF RT   and bone and in buccal-pouch carcinomas of Syrian golden
#=GF RT   hamsters. 
#=GF RA   Sasaguri K, Ganss B, Sodek J, Chen JK; 
#=GF RL   Arch Oral Biol 2000;45:551-562.
#=GF DR   INTERPRO; IPR008412;
#=GF CC   Bone sialoprotein (BSP) is a major structural protein of the
#=GF CC   bone matrix that is specifically expressed by
#=GF CC   fully-differentiated osteoblasts [1]. The expression of bone
#=GF CC   sialoprotein (BSP) is normally restricted to mineralised
#=GF CC   connective tissues of bones and teeth where it has been
#=GF CC   associated with mineral crystal formation. However, it has been
#=GF CC   found that ectopic expression of BSP occurs in various lesions,
#=GF CC   including oral and extraoral carcinomas, in which it has been
#=GF CC   associated with the formation of microcrystalline deposits and
#=GF CC   the metastasis of cancer cells to bone [2]. 
#=GF SQ   64
#=GS M7AV71_CHEMY/343-611     AC M7AV71.1
#=GS I3J5Y8_ORENI/494-621     AC I3J5Y8.1
#=GS F6TZH2_MACMU/17-315      AC F6TZH2.1
#=GS I3J5Y7_ORENI/523-650     AC I3J5Y7.1
#=GS L9L562_TUPCH/2-276       AC L9L562.1
#=GS H0YVI3_TAEGU/95-287      AC H0YVI3.1
#=GS G3QVT7_GORGO/60-294      AC G3QVT7.1
#=GS V8NVG6_OPHHA/1-246       AC V8NVG6.1
#=GS A0JPM6_RAT/17-316        AC A0JPM6.1
#=GS F6TAB6_CHICK/17-89       AC F6TAB6.1
#=GS M3XT14_MUSPF/17-315      AC M3XT14.1
#=GS G1KML5_ANOCA/17-319      AC G1KML5.2
#=GS SIAL_CHICK/77-273        AC P79780.1
#=GS L5M3T3_MYODS/1-66        AC L5M3T3.1
#=GS F7G8V1_MONDO/17-304      AC F7G8V1.1
#=GS F7EC64_ORNAN/17-303      AC F7EC64.1
#=GS D2GX57_AILME/17-317      AC D2GX57.1
#=GS F7I699_CALJA/17-314      AC F7I699.1
#=GS G3VPY7_SARHA/17-313      AC G3VPY7.1
#=GS SIAL_BOVIN/17-307        AC Q28862.1
#=GS W5NY83_SHEEP/17-303      AC W5NY83.1
#=GS F6TAB6_CHICK/77-273      AC F6TAB6.1
#=GS W5NY80_SHEEP/9-278       AC W5NY80.1
#=GS G0SHS4_CHATD/196-318     AC G0SHS4.1
#=GS G3TER7_LOXAF/17-319      AC G3TER7.1
#=GS A0A091DI98_FUKDA/17-320  AC A0A091DI98.1
#=GS G3SAN1_GORGO/17-301      AC G3SAN1.1
#=GS U3JR86_FICAL/17-309      AC U3JR86.1
#=GS G1N6F0_MELGA/17-180      AC G1N6F0.2
#=GS L5M3T3_MYODS/43-214      AC L5M3T3.1
#=GS L9L5F1_TUPCH/101-374     AC L9L5F1.1
#=GS G3ILN2_CRIGR/17-312      AC G3ILN2.1
#=GS G7P5V9_MACFA/4-286       AC G7P5V9.1
#=GS U3I5J2_ANAPL/17-72       AC U3I5J2.1
#=GS A0A0D9QWB7_CHLSB/17-315  AC A0A0D9QWB7.1
#=GS L5KQL8_PTEAL/1-294       AC L5KQL8.1
#=GS H2PDV2_PONAB/17-314      AC H2PDV2.1
#=GS E2RPB1_CANFA/17-315      AC E2RPB1.2
#=GS G1PF90_MYOLU/17-305      AC G1PF90.1
#=GS SIAL_HUMAN/17-314        AC P21815.4
#=GS H2QPV2_PANTR/17-314      AC H2QPV2.1
#=GS G1N6F0_MELGA/139-259     AC G1N6F0.2
#=GS G1REL7_NOMLE/17-314      AC G1REL7.1
#=GS F6YPI2_HORSE/17-308      AC F6YPI2.1
#=GS G1SEM1_RABIT/1-288       AC G1SEM1.2
#=GS H0X499_OTOGA/17-308      AC H0X499.1
#=GS F7I6C9_CALJA/141-291     AC F7I6C9.1
#=GS SIAL_RAT/17-317          AC P13839.1
#=GS G3QVT7_GORGO/17-64       AC G3QVT7.1
#=GS H0YVI3_TAEGU/17-81       AC H0YVI3.1
#=GS M3WAT3_FELCA/17-317      AC M3WAT3.1
#=GS SIAL_CHICK/17-89         AC P79780.1
#=GS I3LYK5_SPETR/17-313      AC I3LYK5.1
#=GS A0A096NDB1_PAPAN/17-314  AC A0A096NDB1.1
#=GS H0VK51_CAVPO/17-307      AC H0VK51.1
#=GS F7I6C9_CALJA/17-146      AC F7I6C9.1
#=GS SIAL_PIG/1-300           AC P31936.2
#=GS H3ALZ7_LATCH/19-308      AC H3ALZ7.1
#=GS K7GP14_PIG/17-316        AC K7GP14.1
#=GS W4W7I7_ATTCE/9-123       AC W4W7I7.1
#=GS SIAL_MOUSE/17-321        AC Q61711.2
#=GS U3I5J6_ANAPL/5-64        AC U3I5J6.1
#=GS G5BSU4_HETGA/17-316      AC G5BSU4.1
#=GS U3I5J2_ANAPL/139-208     AC U3I5J2.1
M7AV71_CHEMY/343-611                ............nkalygklmiwf----------------------..---..--------.-----------P.DNSSDSEEEGDG.DSSEEEEEEEGQ....EQSNEG.N...NG...ENEGEETTTET..PTGKKAV...GKKglgngitkipkKEQDSQSPE.....NAETG.---.----Esskkgg.........gckapgK...GGKS-EGSEGEEDSDENEEEEN.......EEEEEETEKVDENGTGGNGT..S.....TNGTD.....TENGNGGNG-EA..EE......EEEEENETEA-.---------.--TTIVITTPTDPGRG...DTTPTE.D.E-----.-GVYDTTTPGDLWGY..........EngETTTPVYENGYESq..tdYNdgRENGYPRGDSYRTY....EDEY.GYYKGHGYDVY-GHDYY............................
I3J5Y8_ORENI/494-621                .................pvgllvl----------------------..---..--------.------------.------------.------------....------.-...--...-----------..-------...---...........---------.....-----.---.FCWPK.....................K..sDDNYVYKKVDPPKADVEEEEEE.......EEEEEEEAAVDEEDKGAEAT..EaapaaANATE.....EAEEDAEAGGDN..VEg....dDEEEEEEEEEE.EEEDSS---.----------------...------.-.------.---------------..........-..-------------.....--..--------------....----.-----------------ikpdaslsvpqmkdegdvaeeshkqavr
F6TZH2_MACMU/17-315                 ........................FSMKNLHRRVKIEDSEENGVFK..YRP..RYYLYKHA.YFYPPLKRFPVQ.GSSDSSEENGD-.DSSEEEEEEEET....SNEGEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDATPG.....TWYTG.LAA.IQLPK.....................K...AGDVTNKATKKEESDEEEEEEEe.....eNENEESEAEVDENEQGINGT..S.....TNSTE.....AENGNGSSGGDN.gEE......EGEEESVTGASaEGTTATGGQ.GKGSSKTTTSPNGGFE...PTTPPP.-.VYRTTS.LPFGKTTTVEYEGEY..........E..YTGANEYDNGYEV.....YE..SENGEPRGDNYRAY....EDEY.SYFKGQGYDSYDGQNYY............................
I3J5Y7_ORENI/523-650                .................pvgllvl----------------------..---..--------.------------.------------.------------....------.-...--...-----------..-------...---...........---------.....-----.---.FCWPK.....................K..sDDNYVYKKVDPPKADVEEEEEE.......EEEEEEEAAVDEEDKGAEAT..E.....AAPAA....eEAEEDAEAGGDN..VE.....gDDEEEEEEEEE.EEEEEEGEE.ESKAPGRTLEDE----...------.-.------.---------------..........-..-------------.....--..--------------....----.-----------------mkdegdvaeeshkqavrk..........
L9L562_TUPCH/2-276                  ......................vh-------------------VFK..YRP..RYYLYKHA.YFYPPLRRFPVQ.-SSDSSEENGDG.DSSEEEEEGEEA....SNEEEN.N...ED...SNGNEDEDSEA..ENSTLST...TTL...........GYGEEITPG.....TGDTG.LAA.IQLPK.....................E...AGDKRNKATKQKESDEEEEEEEe.....eNENEENEAEVDENEQGINGT..S.....TNSTE.....VDNGNGSSGGDN.gEE......EGEEESVTGAVaEGTTVTRGQ.DNGGSKTTTSSNGGLV...PTTPPQ.-.IYGTTS.VS---------YEEY..........E..HTGTNHYDNEYEV.....YE..NENGEPRGDNYRAY....EDEY.SYYKGQGYGGYGDQDYY............................
H0YVI3_TAEGU/95-287                 adcwgvghpagvspedcqgaltgd----------------------..---..--------.------------.------------.------------....------.-...--...-----------..-------...---...........---------.....-----.---.-----.....................-...------RTANKEEDSENEDSDE.......NEEEEEDEEVDENENGVNGT..S.....TNTTEg...iGPHGNGTVVAEE..AT......EEEEEEEEEE-.---EEEEEA.EATTIASTTNEEGLTQ...ATTMDD.GgPTDATT.----DATTAGELWEY..........D..VTARDH-SRGEEGtteggYE..EQDEYARGDSYRAY....EDEY.GYYKGHGYDVY-GQDYY............................
G3QVT7_GORGO/60-294                 .......................v----------------------..---..--------.------------.------------.--------QEET....SNEGEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDATPG.....TGYAG.LAA.IQLPK.....................K...AGDITNKATKEKESDEEEEEEEe.....eNENEESEAEVDENEQGINGT..S.....TNSTE.....AENGNGSSGGDN..GE......EGEEESVTGANaEGTTETGGQ.GKGTSKTTTSPNGGFE...PTTPPQ.-.VYRTTS.PPFGKITTVEYEGEY..........E..YTGANEYDNGYEI.....YE..SENGEPRGDNYRAY....EDEY.SYFKGQGYDGYDGQNYY............................
V8NVG6_OPHHA/1-246                  ......................mp----------------------..---..--------.-----QNCLSFQ.FNSDSSEEGFGG.NSSEEEEEEEGG....-QSNEE.N...EG...GKGS-------..EETTVAP...TTP...........AAGDTNTDGnaeppTEVPG.VKDpLQKPGkeg...............gdkK...VDNAPKKGAKEEDSDENEEEEN.......--EEEEEEKVDENGSGANGT..S.....TNSTL.....EETGNGGEE---..--......--EEEEENEA-.--TTI----.SLTTLVTTVNPT---E...STTGEQ.W.Q-DGTS.PADQGQYDTEDPWVH..........D..ATTTNGYEVQTDY.....YG..SENGYPRGDNFRTY....EDEY.SYYKGHGYDVY-GQDYY............................
A0JPM6_RAT/17-316                   ........................FSMKNFHRRIKAEDSEENGVFK..YRP..RYFLYKHA.YFYPPLKRFPVQ.GGSDSSEENGDG.DSSEEEGEEEET....SNEEEN.N...ED...SEGNEDQEAEA..ENATLSG...VTA...........SYGVETTAD.....AGKLE.LAA.LQLPK.....................K...AGDAEGKAPKMKESDEEEEEEE......eEENENEEAEVDENEQVVNGT..S.....TNSTE.....VDGGNGPSGGDN..GE......EAEEASVTEAGaEGTTAGARElTSYGTTTAVLLNG-FQ...QTTPPP.E.AYGTTS.PPARKSSTVEYGEEY..........E..QIGN-EYNTAYET.....YD..ENNGEPRGDTYRAY....EDEY.SYYKGHGYEGYEGQDYY............................
F6TAB6_CHICK/17-89                  ........................FSVRSWLRRARAGDSEENAVLK..SRH..RYYLYRYA.--YPPLHRYK--.-GSDSSEEEGDG.--SEEEEEGGA-....------.-...--...-----------..-------...---...........---------.....-----.---.-----.....................-...----------------------.......--------------------..-.....-----.....------------..--......-----------.---------.----------------...------.-.------.---------------..........-..-------------.....--..--------------....----.-----------------pshagtqaageg................
M3XT14_MUSPF/17-315                 ........................FSMKNLHRRAKLQDSEENGVFK..YRP..RYSLYKHA.YFYPPLKRFLAQ.SSSDSSEEDGNG.DSSEEEEEEEET....SNEEEN.N...EEnanSDENED-EDEA..ENTTLST...-TP...........GYGE-TTPG.....TGYIG.LAA.IQLPK.....................K...AGDKGHKATEEEESDEEEEEDE.......-ENEENEAEVDENGQGINGT..S.....SNSTE.....AENGNGSSDGDN..GE......EGEEQSVTEAQtEGTTVARKQ.DNGDSKTTTSPDGGFE...PTTPPP.E.FYGTTT.QQSGEATPTGYEEEY..........E..QTGTNEYDNGYEV.....YE..NENGEPRGDNYRAY....EDEY.SYYKGRSYDGYDGQDYY............................
G1KML5_ANOCA/17-319                 ........................FSVKSFRRRFKADDSEENAVFK..NRF..WPFFYRQP.YLYPPMKR--QQ.FNSDSSEEGYGG.NSSEEEEEEEAG....----PS.N...EE...-NEGEQEKEEA..---TKAP...SEP...........ATGDKK---.....----G.VSD.SKPPKqvpvkkeplgkpgkeggakkaE...KDKAPEKGGKEEEEDSDENEEEe....neEEENEEQEKVDENGNGVNGT..S.....TNSTA.....EENGNGGKG---..-E......EEEEEEENEA-.---------.------TTIVPTTLFTtvvPTTEYQ.D.QYDTTTeEQWHAETTPEDQWQYdtttedpwvhD..TTTTTGYENGYETqt.dyYG..SENGYPRGDTFRAY....EDEY.SYYKGHGYDVY-GQDYY............................
SIAL_CHICK/77-273                   ..apshagtqaagegltlgdvgpg----------------------..---..--------.------------.------------.------------....------.-...--...-----------..-------...---...........---------.....----G.DAA.SAHQD.....................C...KGGQKGTRGDSGDEDSDEEEEE.......EEEEEEEEEVEEQDVSVNGT..S.....TNTTA....eTPHGNNTVAAEE..EE......DDDEEEEEEEE.----EEEEA.EATTAAA---------...-TTAQD.E.VTTLGD.EQRSEVTTAGEQWEY..........E..VTVGARGDEGPTEs...sYG..DQEEPARGDSYRAY....EDEY.GYYKGHGYDMY-GQDYY............................
L5M3T3_MYODS/1-66                   ........................--MKNFHRRAKLEDSEENAVFK..YRP..RYYLYKHA.YFYPPLKRFAVQ.-AGDVGKKATKK.EESEEEEEEEE-....------.-...--...-----------..-------...---...........---------.....-----.---.-----.....................-...----------------------.......--------------------..-.....-----.....------------..--......-----------.---------.----------------...------.-.------.---------------..........-..-------------.....--..--------------....----.-----------------e...........................
F7G8V1_MONDO/17-304                 ........................FSAKHLYRRAKLEDSEENGVFN..HRH..RYYLNKYS.YFYPPLKRIPVQ.HNGDSSEE-GDG.DSSEEEEEEEET....SNEEES.E...--...TNGSEDEEEEG.gESTTLSA...TTS...........GYEEENTTA.....SGDVG.LAA.IQIPK.....................K...GEDSKNNTKKEE-SDEEEEEEEe.....eEENKESEAEVDKNKEVVNGT..D.....H----.....-GDGNGTSG---..KE......DGEEEEEVE--.NGTESSVDK.DNNSTELATSPNSRYE...STTPLE.G.TYEVTS.PPYEESTSNLYDSGY..........E..EPVTNEYDNGYEI.....YE..NENGEPRGDNYRAY....EDEY.SYYKGHPYNGYEGQDYY............................
F7EC64_ORNAN/17-303                 ........................FSVKNLHRRAKVEESEENAVFK..HRP..RYYIYKYA.YLYPPQKRILSQ.GSIPSSQERDDG.EKEGEIDINETS....NEENEE.N...EE...----EDENSEG.eESTTVSA...TTP...........LYGEETTPG.....RGDNG.LGA.IKVPK.....................K...NGDVQNTGMANKMKHIENLTAEtr..kstNENEESEAEVEENEQGINGT..S.....TNSTE.....DS---GNDGGEN.gGEa....aEEEEESVTEAN.-------QE.ENGGQETTTFVDSVQG...ATTPSN.G.AYEVTT.PP---TTSN----GY..........E..ETVTNEYDSGYEV.....YE..NENAEPRGDNFRTY....EDEY.SNYKGRGYDGYDGRDYY............................
D2GX57_AILME/17-317                 ........................FSMKNLHRRAKLEDSEENGVFK..YRP..RYSLYKHA.YFYPPLKRFPVQ.SSSDSSEEDGNG.DSSEEEEEEEET....SNEEEN.N...EEnanSDENEDEESEA..ENTTLTA...-TP...........GYGEETTPG.....TGYIG.LAA.IQLPK.....................K...SGDIGHKATKEEESDEEEEEDE.......-ENEENEAEVDENGQGINGT..S.....SNSTE.....AENGNGSSDGDN..GE......EGEEESVTEAHtEGTTVVGKQ.DNGGSKTTVSPDGGFE...RTTPPP.E.LYGTTT.RPSGEATPTGYEGEY..........E..QTGTNEYDNGYEV.....YE..NENGEPRGDNYRAY....EDEY.SYYKGRSYDGYDGQDYY............................
F7I699_CALJA/17-314                 ........................FSMKNLHRRVKIEDSEENGVFK..YRP..RYYLYKHA.YFYPPLKRFPVQ.GNSDSSEENGD-.DSSEEEEEEEGA....SNEEEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDATPG.....TGYTG.LAA.IQLPK.....................K...AGYITNKAMKKKESDEEEEEEE......eEENEESEAEVDENEQGINGT..S.....TNSTE.....AENGNGSSGGDN.gEE......EGEVESVTGASaEGTTATRGQ.GKSTSKTTTSPNGDFE...PTTPPQ.-.PYRTTS.PPFGKTTTVEYEGEY..........E..HTGTSEYDNGYEV.....YE..SENGEPRGDSYRAY....EDEY.SYFKGHGYDGYGGQDYY............................
G3VPY7_SARHA/17-313                 ........................FSVKNLYRRAKLGDSEENGVLN..HRH..RYYIYKYS.YLYPPLKRIPVQ.RNGDSSEE-GDG.ESSEEEEEEEDTnrfsKNRLFN.K...EN...SNEEEETESNGseESTTLSA...TTL...........GYGEENTTA.....SGDIG.LAA.IQNPK.....................K...PEEKNNQVTKKEESDEEEEEEE.......-ENEESEAEVDENKEGGNST..N.....HENAE.....GDHGNGNGG---..KE......EGEEEEEVE--.NGTEATENE.ASNSTEVTTSLNG-YE...FTTLLK.G.DFEVTS.PPYEESTSNLYDSGY..........E..EPVTNEYDNGYEV.....YE..NENREPRGDNYRAY....EDEY.SYYKGHAYNGYGGQDYY............................
SIAL_BOVIN/17-307                   ........................LSMKNLNRRAKLEDSEENGVFK..YRP..QYYVYKHG.YFYPALKRFAVQ.SSSDSSEENGNG.DSSEEEEEEEET....SNEEGN.NggnED...SDENEDEESEA..ENTTLST...TTL...........GYGE-ITPG.....TGDIG.LAA.IWLPR.....................K...AGATGKKATKEDESDEEEEEEE.......--EEENEAEVDDNEQGINGT..S.....SNSTE.....VDNGHGSSGGDN.gEE......DGEEESVTEANtEGITVAG--.-----ETTTSPNGGFK...PTTPHQ.E.VYGTTP.PPFGKITTP---GEY..........E..QTGTNEYDNGYEI.....YE..SENGDPRGDNYRAY....EDEY.SYYKGRGYDSYDGQDYY............................
W5NY83_SHEEP/17-303                 ........................LSMKNLHRRAKLEDSEENGVFK..YRP..RYYLYKHA.YFYPALKRFAVQ.SSSDSSEENGNG.DSSEEEEEEEET....SNEEGN.NggnED...SDENEDEESEA..ENSTLST...TTL...........GYGEEITPG.....TGHIG.LAA.IRLPK.....................K...AGATGKKATKEDESDEEEEEEE.......--EEENEAEVDDHEQGINGT..S.....SNSTE.....ADNGHGTSGGDN..GE......EDGEEESTE--.-GITVAG--.-----ETTASPNGGFK...STTPPQ.E.VYGTTP.PPFGETTTP---GEY..........E..QTGTNEYDNGYEI.....YE..SENGDPRGDSYRAY....EDEY.SYYKGRGYDSYDGQDYY............................
F6TAB6_CHICK/77-273                 ..apshagtqaagegltlgdvgpg----------------------..---..--------.------------.------------.------------....------.-...--...-----------..-------...---...........---------.....----G.DAA.SAHQD.....................C...KGGQKGTRGDSGDEDSDEEEEE.......EEEEEEEEEVEEQDVSVNGT..S.....TNTTA....eTPHGNNTVAAEE..EE......DDDEEEEEEEE.----EEEEA.EATTAAA---------...-TTAQD.E.VTTLGD.EQRSEVTTAGEQWEY..........E..VTVGARGDEGPTEs...sYG..DQEEPARGDSYRAY....EDEY.GYYKGHGYDMY-GQDYY............................
W5NY80_SHEEP/9-278                  .......................m------------------QVFK..YRP..RYYLYKHA.YFYPALKRFAVQ.SSSDSSEENGNG.DSSEEEEEEEET....SNEEGN.NggnED...SDENEDEESEA..ENSTLST...TTL...........GYGEEITPG.....TGHIG.LAA.IRLPK.....................K...AGATGKKATKEDESDEEEEEEE.......--EEENEAEVDDHEQGINGT..S.....SNSTE.....ADNGHGTSGGDN..GE......EDGEEESTE--.-GITVAG--.-----ETTASPNGGFK...STTPPQ.E.VYGTTP.PPFGETTTP---GEY..........E..QTGTNEYDNGYEI.....YE..SENGDPRGDSYRAY....EDEY.SYYKGRGYDSYDGQDYY............................
G0SHS4_CHATD/196-318                .........rarsrravtptpapr----------------------..---..--------.------------.------------.------------....------.-...--...-----------..-------...---...........------TAG.....ARAPGpLAA.FAAAW.....................G...AQRKQKQKQKQQEEEEEEEEEE......eEEEEEEEKEEEEDRQVFVGV..S.....GNMPAccawhWPPHTGNCGGDS..DSrgvttpEKEEEGEE---.---------.----------------...------.-.------.---------------..........-..-------------.....--..--------------....----.-----------------qagvslfv....................
G3TER7_LOXAF/17-319                 ........................FSMKNLHRRAKLEDSEENRVFK..FRP..QYYLYKHA.YFYPPQKRFPVL.SNSDSSEENGDG.YSSEEEEEEEES....SNEGEN.N...EEneeSNENEEEESEA..ENTTLST...ATP...........GYGEETTPG.....TGSLG.LAA.IQLPK.....................K...AKVIPTLNVPSLVQSHFREENS......kIEKVSRKAEVDENEQGINGT..S.....TNSTD.....TENGNGSNGGDH.gEE......EGEEESVTEANaEEATVTGEQ.GNGGLETTASPNAGFQ...PTAPPQ.D.IYGTTT.PPFGEITTTGY--EY..........E..QTGTNEYDNGYEV.....YE..NENGEPRGDNYRAY....EDEY.SYYKGRSYDGYDGQDYY............................
A0A091DI98_FUKDA/17-320             ........................FSMKNLQRRFKLEDSEENGVFK..YRP..RYYLYKYG.YLYPPLKRFAVQ.GNSDSSEENGGG.DSSEEEED-EET....SNEEEN.N...ED...SNGNEDEESET..VNTTLSS...VTP...........GYGEETTPE.....TDYIG.LAA.IQLPK.....................K...AGDTGYKATKKEESDEEEEEEEee...eeNENENNEAEVDENEQAVNGT..S.....TNSTA.....VENGNGSSGADN.gDE......EGGEESVTEANmAGTTVVAGQ.STGSSKTTPSPNGGFE...PTTPAP.N.VYGSTS.PPYEKTTTAEYGAEY..........E..QSRANAYDPGYEV.....YD..SENGEPRGDNYRAY....EDEY.SYYKGRGYDGYDGQDYY............................
G3SAN1_GORGO/17-301                 ........................FSMKNLHRRVKIEDSEENGVFK..YRP..RYYLYKHA.YFYPHLKRFPVQ.GNKDSSQEHTHTtHTSLKRGEVKET....SNEGEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDATPG.....TGYAG.LAA.IQLPK.....................K...AGDITNKATKEKE---------.......----SGEAEVDENEQGINGT..S.....TNSTE.....AENGNGSSGGDN..GE......EGEEESVTGANaEGTTETGGQ.GKGTSKTTTSPNGGFE...PTTPPQ.-.VYRTTS.PPFGKITTVEYEGEY..........E..YTGANEYDNGYEI.....YE..SENGEPRGDNYRAY....EDEY.SYFKGQGYDGYDGQNYY............................
U3JR86_FICAL/17-309                 ........................FSVKSWLRRPKWDNSEENAVFK..SRH..RHYLYRYI.YVYPPQRRYQ--.-GSDSSEEEGDG.--SEEEEGGEPF....YAGTKA.A...G-...------HPAGA..APGDCQD...ALG...........GYVSSPQQG.....KDCQGtLKG.I----.....................-...RQRIASKGEDSENEDSDENEEE.......-EEEEEEEEVDENENGVNGT..S.....TNTTEg...iGPHGNGTVAAEEgtGEa...eeEEEEEEEEEEE.EEEEEEEET.EATTIPSTTNDEGLTQ...ATTMDDgG.PTDATT.DATTDATTAGELWEY..........D..VTAR-EHSRGEEGttepgYE..EQDEYARGDSYRAY....EDEY.GYYKGHGYDVY-GQDYY............................
G1N6F0_MELGA/17-180                 ........................FSVRSWLRRARAGDSEENAVLK..SRH..RYYLYRYA.--YPPLHRYKVG.PGSDSSEEEEDG.--SEEEEDGGVS....--IGLQ.H...AE...---IQGLASEP..SHSFLDE...CTQ...........AAGEGLTPG.....DTELG.GDA.ASTHQpcpc............vpqgcK...GGQKGTRGDSGD-EDSDEEEEE......eEEEEEEEEEEEEA-------..-.....-----.....------------..--......-----------.---------.----------------...------.-.------.---------------..........-..-------------.....--..--------------....----.-----------------eatttaa.....................
L5M3T3_MYODS/43-214                 ......................qa----------------------..---..--------.------------.------------.------------....------.-...--...-----------..-------...---...........---------.....-----.---.-----.....................-...-GDVGKKATKKEESEEEEEEEEee...eeNENEENEAEVDENGQGVNGT..S.....TNSTD.....AENGNGSSGGDN..GE......EGEEEGEEENA.EGTTVAGEQ.D----------NGGSE...PTTPPQ.E.AYGTTP.PPQGGTTTTEYEEEY..........E..QTGTNEYDNGYEV.....YE..NENAEPRGDNYRAY....EDEY.SYYKGRGYDSYDGQNYY............................
L9L5F1_TUPCH/101-374                kflalgthygkvylldvqgnitqk----------------------..---..--------.----------FD.VSSDSSEENGDG.DSSEEEEEGEEA....SNEEEN.N...ED...SNGNEDEDSEA..ENSTLST...TTL...........GYGEEITPG.....TGDTG.LAA.IQLPK.....................E...AGDKRNKATKQKESDEEEEEEEe.....eNENEENEAEVDENEQGINGT..S.....TNSTE.....VDNGNGSSGGDN.gEE......EGEEESVTGAVaEGTTVTRGQ.DNGGSKTTTSSNGGLV...PTTPPQ.-.IYGTTS.VS---------YEEY..........E..HTGTNHYDNEYEV.....YE..NENGEPRGDNYRAY....EDEY.SYYKGQGYGGYGDQDYY............................
G3ILN2_CRIGR/17-312                 ........................FSMKNLHRRVKAEDSEENGVFK..YRP..RYFLYKHA.YFYPPLKRFPVQ.GGSDSSEENGDG.DSSDEEGE-EET....SNEEEN.N...ED...SEGNEDEEAEA..GNTTLSS...VTA...........SYGAETTTE.....AGSIG.LAA.LQLPK.....................K...AGDAESKAAKNKESDEEEEEEE.......-ENENEEAEVEENEQVANGT..S.....ANSTE.....AYGGNSSSGGDN..G-......EGEEQSVTEAGvEGTTLDREQ.ISDGPTTAVLPNG-FQ...YTTPPP.E.AYGTTA.PPFRKPTTAEYWGEY..........E..QTGNNEDNGEYQI.....YD..NENGEPRGDTYRAY....EDEY.SYYKGRGYEGYDGQDYY............................
G7P5V9_MACFA/4-286                  ......................af------------------SVFK..YRP..RYYLYKHA.YFYPPLKRFPVQ.GSSDSSEENGD-.DSSEEEEEEEET....SNEGEN.N...EE...SNEGE--DSEA..ENTTLSA...TTL...........GYGEDATPG.....TWYTG.LAA.IQLPK.....................K...AGDVTNKATKKEESDEEEEEEEe.....eNENEESEAEVDENEQGINGT..S.....TNSTE.....AENGNGSSGGDN.gEE......EGEEESVTGASaEGTTATGGQ.GKGSSKTTTSPNGGFE...PTTPPP.-.VYRTTS.LPFGKTTTVEYEGEY..........E..YTGANEYDNGYEV.....YE..SENGEPRGDNYRAY....EDEY.SYFKGQGYDSYDGQNYY............................
U3I5J2_ANAPL/17-72                  ........................FSVKSWLRRVGGDNSEENAVFK..NRR..RYYLYRYA.YL--PQQRYQ--.-GSDS-------.------------....------.-...--...-----------..-------...---...........---------.....-----.---.-----.....................-...----------------------.......--------------------..-.....-----.....------------..--......-----------.---------.----------------...------.-.------.---------------..........-..-------------.....--..--------------....----.-----------------llaiggeekkh.................
A0A0D9QWB7_CHLSB/17-315             ........................FSMKNLHRRVKIEDSEENGVFK..YRP..RYYLYKHA.YFYPPLKRFPVQ.GSSDSSEENGE-.DSSEEEEEEEET....SNEGEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDATPG.....TWYTG.LAA.IQLPK.....................K...AGDVTNKATKKEESDEEEEEEEe.....eNENEESEAEVDENEQGINGT..S.....TNSTE.....AENGNGSSGGDN.gEE......EGEEESVTGANaEGTTATGGQ.GKGSSKTTTSPNGGFE...PTTPPP.-.VYRTTS.PPFGKTTTVEYEGEY..........E..YTGANEYDNGYEV.....YE..SENGEPRGDNYRAY....EDEY.SYFKGQGYDSYDGQNYY............................
L5KQL8_PTEAL/1-294                  ........................--MKNFHRRAKLEDSEENGVFK..YRP..RYYLYKHA.YFYPPLKRFPVQ.-SSDSSEENEDG.DSSDEEEEEEET....SNEEAN.N...EE...SDENEDEESEA..ENSTLSA...TTP...........GYGEETTPE.....AGNIG.LAA.IQLPK.....................K...TGDTGKKATKKEESDEEEEEEEeeeeeeeNENEENEAEVDENGQGVNGT..S.....TNSTE.....VENGNGSSGGDN..EE......EREEESVPDANaEGNTVAGEQ.----------DNGRLE...PTTPPQ.E.VYGATT.PTLEKTTTTEYEGEY..........E..QTGTNEYDNGYEV.....YE..NENGEPRGDNFRAY....EDEY.SYYKGHSYDGYDGQNYY............................
H2PDV2_PONAB/17-314                 ........................FSMKNLHRRVKIEDSEENGVFK..YRP..RYYLYKHA.YFYPHLKRFPVQ.GSSDSSEENGD-.DSSEEEEEEEET....SNEGEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDATLA.....TGYPG.LAA.IQLPK.....................K...AGDITSKATKEEESDEEEEEEEe.....eNENEESEAEVDENEQGINGT..S.....TNSTE.....AENGNGSSGGDN..GE......EGEEESVTGANaEGTTATGGQ.GKGSSKTTTSPNGGFE...PTTPPQ.-.VYRTTS.PPFGKTTTVEYEGEY..........E..YTGANEYDNGYEI.....YE..SENGEPRGDNYRAY....EDEY.SYFKGQGYDGYDGQNYY............................
E2RPB1_CANFA/17-315                 ........................FSMKNLHRRAKLEDSEENGVFK..YRP..RYYLYKHS.YFYPPLKRFPVQ.SSSDSSEEDGDG.DSSEEEEEEEET....SNEEEN.N...EEnanSDENE-DESDA..ENSTLSA...-TP...........GYGEEITPG.....TGYIG.LAA.IQLPK.....................K...AGDIRHKATKEEESDEEEEEDE.......-ENEENEAEVDENGQGINST..S.....SNSTE.....AENGNGSSAGDN..G-......EGEEESVTEAHsEGTTEAGKQ.NNGGSKTTLSPDGGFE...PTTPPP.E.LYGTTT.RPSGEATPNGYEEEY..........E..QTGTNEYDNGYEV.....YE..SENGEPRGDNYRAY....EDEY.SYYKGHSYDSYDGQDYY............................
G1PF90_MYOLU/17-305                 ........................FSMKNFHRRAKLEDSEENGVFK..YRP..RYYLYKHA.YFYPPLKRFPVQ.-NSDSSEENGDG.DSSEEEEGEEEN....SNEEAN.N...EE...--SNEDEESEA..ENSTLSA...TTP...........GYGEETTPG.....TGNVG.LAA.IQLPK.....................K...AGDVGKKATKKEESEEEEEEEEe....eeNENEENEAEVDENGQGVNGT..S.....TNSTD.....VENGNGSSGGDN..GE......EEEEEGEEETA.EGTTVAGEQ.D----------NGGFE...PTTPPQ.E.VYGTTP.PPQGGTTTTEYEGEY..........E..QTGTNEYDNGYEV.....YE..NENAEPRGDNYRAY....EDEY.SYYKGRGYDSYDGQNYY............................
SIAL_HUMAN/17-314                   ........................FSMKNLHRRVKIEDSEENGVFK..YRP..RYYLYKHA.YFYPHLKRFPVQ.GSSDSSEENGD-.DSSEEEEEEEET....SNEGEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDATPG.....TGYTG.LAA.IQLPK.....................K...AGDITNKATKEKESDEEEEEEEe.....gNENEESEAEVDENEQGINGT..S.....TNSTE.....AENGNGSSGGDN..GE......EGEEESVTGANaEDTTETGRQ.GKGTSKTTTSPNGGFE...PTTPPQ.-.VYRTTS.PPFGKTTTVEYEGEY..........E..YTGANEYDNGYEI.....YE..SENGEPRGDNYRAY....EDEY.SYFKGQGYDGYDGQNYY............................
H2QPV2_PANTR/17-314                 ........................FSMKNLHRRVKIEDSEENGVFK..YRP..RYYLYKHA.YFYPHLKRFPVQ.GSSDSSEENGD-.DSSEEEEEEEET....SNEGEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDTTPG.....TGYTR.LAA.IHLPK.....................K...AGDITNKATKEKESDEEEEEEEe.....eNENEESEAEVDENEQGINGT..S.....TNSTE.....AENGNGSSGGDN..GE......EGEEESVTGANaEGTTETGGQ.GKGSSKTTTSPNGGFE...PTTPPQ.-.VYRTTS.PPFGKTTTVEYEGEY..........E..YTGANEYDNGYEI.....YE..SENGEPRGDNYRAY....EDEY.SYFKGQGYDGYDGQNYY............................
G1N6F0_MELGA/139-259                ..................ggqkgt----------------------..---..--------.------------.------------.------------....------.-...--...-----------..-------...---...........---------.....-----.---.-----.....................-...----------------------.......--------------------..-.....-----.....----RGDSG-DE..DS......DEEEEEEEEE-.-EEE--EEE.EEEAEATTT------A...ATTAQD.E.VTTLGN.EQHSEATTAGEQWEY..........E..VTVGARGDEGPTEg...sYG..DQEGPARGDSYRAY....EDEY.GYYKGHGYDIY-GQDYY............................
G1REL7_NOMLE/17-314                 ........................FSMKNLHRRVKIEDSEENGVFK..HRP..RYYLYKHA.YFYPHLKRFPVQ.GSSDSSEENGD-.DSSEEEEEEEET....SNEGEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDATPG.....IGYTG.LAA.IQLPK.....................K...AGDITNKATKEKESDEEEEEEEe.....eNENEESEAEVDENEQGINGT..S.....TNSTE.....AENGNGSSGGDN..GE......EGEEESVTGANaEGTTATGGQ.GKGSSKTTTSPNGGFE...PTTPPQ.-.VYRTIS.PPFGKTTTVQYEGEY..........E..YTGANEYDDGYEI.....YE..SENGEPRGDNYRAY....EDEY.SYFKGQGYDGYDGQNYY............................
F6YPI2_HORSE/17-308                 ........................LSMKNLHRRAKLEDSEENGVYK..YRP..QYSLYKHA.YFYPPLKRFPVQ.TSSDSSEENGDG.DSSEEEEEEEET....SNEEGN.N...GEnedSEGNEDEESDA..ENTTLST...ITP...........GYGEEPTPG.....MGNIG.LAA.IQLPK.....................K...AGDKGNKGTKEEESDEEEEEEE.......DENEENEAEVDENGQGINGT..S.....SNSTE.....AENGHGSSGGDN..GE......EEGEEEANA--.EGTAVPAEQ.DNAGSKTTTSPNGGFA...PTTPPQ.E.VYRTTT.--------TAYEGEY..........E..QTGTNEYDNGYEV.....YE..NENGEPRGDNYRAY....EDEY.SYYKGRSYDGYDGQDYY............................
G1SEM1_RABIT/1-288                  ........................--MKNLHRRVKLQDSEENGVFK..FRP..QYYLYKHA.YFYPPLKRFPVP.-SSDSSEENGEG.DSSDEEEEGEET....SNEEEN.N...ED...SNGNEDEESEA..ENSTLSF...TTP...........DYGE-ITRG.....TGYIG.LAG.IKLPK.....................K...AGAIENKATEEEESDEEEEEEE......eNENEENEAEVDENEQSINGT..S.....SNSTE.....AEN---------..GE......AGEGESVTATDaAGTATRGEW.ISRAAETTTAPSGGFE...PTTPPP.E.AYGTTS.PPFGKTTAAEYGGEY..........E..QTGNHGYDDGYEI.....YE..NENGDPRGDNYRAY....EDEY.SYYKGRGYEGYEGQDYY............................
H0X499_OTOGA/17-308                 ........................FSMKNLHRRVKPEDSEENGVFK..YRP..RYYLYKHA.YFYPALKRFPVQ.SSSDSSEENEDG.DSSEEEEEEEET....SNEEEK.D...EN...SNGGRYLTREF..KALEKSA...TM-...........GEGVLQVQG.....HGRMGsELS.FCFSF.....................Q...AGDMRKQATKKEESDEEEEEEEe....eeNENEENEAEVDENDQGVNGT..S.....TNSTE.....TENGNGSSGGDA..GE......GGEGDSVTG--.--------E.TAGTRGQTTSPNGGFQ...PTTPPP.E.VYGTPS.PPSGKTTTFEYEEEY..........E..QTGTNEYDNGYEV.....YD..SENGEPRGDTYRAY....EDEY.SYYKGQSYDGYEGYYY-h...........................
F7I6C9_CALJA/141-291                .....................tnk----------------------..---..--------.------------.------------.------------....------.-...--...-----------..-------...---...........---------.....-----.---.-----.....................-...----------------------.......--------AMDENEQGINGT..S.....TNSTE.....AENGNGSSGGDN.gEE......EGEVESVTGASaEGTTATRGQ.GKSTSKTTTSPNGDFE...PTTPPQ.-.PYRTTS.PPFGKTTTVEYEGEY..........E..HTGTSEYDNGYEV.....YE..SENGEPRGDSYRAY....EDEY.SYFKGHGYDGYGGQDYY............................
SIAL_RAT/17-317                     ........................FSMKNFHRRIKAEDSEENGVFK..YRP..RYFLYKHAtYFYPPLKRFPVQ.GGSDSSEENGDG.DSSEEEGEEEET....SNEEEN.N...ED...SEGNEDQEAEA..ENATLSG...VTA...........SYGVETTAD.....AGKLE.LAA.LQLPK.....................K...AGDAEGKAPKMKESDEEEEEEE......eEENENEEAEVDENEQVVNGT..S.....TNSTE.....VDGGNGPSGGDN..GE......EAEEASVTEAGaEGTTAGVRE.LTSYGTTTAVLLNGFQ...QTTPPP.E.AYGTTS.PPARKSSTVEYGEEY..........E..QIGN-EYNTAYET.....YD..ENNGEPRGDTYRAY....EDEY.SYYKGHGYEGYEGQDYY............................
G3QVT7_GORGO/17-64                  ........................FSMKNLHRRVKIEDSEENGVFK..YRP..RYYLYKHA.YFYPHLKRFPVQ.E-----------.------------....------.-...--...-----------..-------...---...........---------.....-----.---.-----.....................-...----------------------.......--------------------..-.....-----.....------------..--......-----------.---------.----------------...------.-.------.---------------..........-..-------------.....--..--------------....----.-----------------et..........................
H0YVI3_TAEGU/17-81                  ........................FSVKNWLLRPRLDDSEENAVFK..RQH..RHYLYKYI.YVYSPQRRYQ--.-GSDSSEEEGDG.--SEEEGE----....------.-...--...-----------..-------...---...........---------.....-----.---.-----.....................-...----------------------.......--------------------..-.....-----.....------------..--......-----------.---------.----------------...------.-.------.---------------..........-..-------------.....--..--------------....----.-----------------gglpr.......................
M3WAT3_FELCA/17-317                 ........................FSTKNLHRRAKLEDSEENGVFK..YRP..RYYLYKNA.YFYPPLKRFPVQ.SSSDSSEENGDG.DSSEEEEEEEEA....SNEEEN.N...EEnanSDENEDEESEA..ENTTLSA...-TP...........GYGEETTPG.....TGNIG.LAA.IQLPK.....................K...AGDTK-KATREEESDEEEEEDE.......-ENEETE-EVDENEQGINSTstS.....TNSTE.....VENGNGSSDGNT..GE......EGEEESVTEVNaEGTTMAGRQ.DNGGSTTTTSPNGGFQ...PTTPPP.E.FYGTTI.RPSREATTTGYEEEY..........E..QTGTNEYDNGYEV.....YE..NENGEPRGDNYRAY....EDEY.SYYKGRSYDSYDGQDYY............................
SIAL_CHICK/17-89                    ........................FSVRSWLRRARAGDSEENAVLK..SRH..RYYLYRYA.--YPPLHRYK--.-GSDSSEEEGDG.--SEEEEEGGA-....------.-...--...-----------..-------...---...........---------.....-----.---.-----.....................-...----------------------.......--------------------..-.....-----.....------------..--......-----------.---------.----------------...------.-.------.---------------..........-..-------------.....--..--------------....----.-----------------pshagtqaageg................
I3LYK5_SPETR/17-313                 ........................LSMKNLHRRIKLEDSEENGVFK..FRP..RYYLYKHA.YFYPPLKRFPVQ.GSSDSSEENGDG.DSSDEEEEEEET....SNEEEN.N...ED...SNGNEDEESEA..ENTTLSA...TTP...........GYGEEVTPG.....TGNMG.LAA.IQLPK.....................K...VGDLGNKATKKKESDEEEEEEE.......-ENEENEAEVDENEQGINGT..S.....TNSTE.....VENGNGSSGGDN.rEE......EGGQESVTRANvRGTT---QQ.NNGGYKTTTPQNGGFQ...PTTPPP.E.VYGTTS.PPFGRTTTVEYEGEY..........E..QMGTNEYGHDYEV.....YD..NENGEPRGDTYRAY....EDEY.SYYKGQGYGGYDSQNYY............................
A0A096NDB1_PAPAN/17-314             .....................wpt---RTFTKRVKIEDSEENGVFK..YRP..RYYLYKHA.YFYPPLKRFPVQ.GSSDSSEENGD-.DSSEEEEEEEET....SNEGEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDATPG.....TWYTG.LAA.IQLPK.....................KvtvELFLQNEIITINNNDKKRSSAR.......--EENSKTEKDENEQGINGT..S.....TNSTE.....AENGNGSSGGDN.gEE......EGEEESVTGASaEGTTATGGQ.GKGSSKTTTSPNGEFE...PTTPPP.-.VYRTTS.PPFGKTTTVEYEGEY..........E..YTGANEYDNGYEV.....YE..SENGEPRGDNYRAY....EDEY.SYFKGQGYDSYDGQNYY............................
H0VK51_CAVPO/17-307                 ........................FSMKNLHRRVKLEDSEENGVFK..YRP..RYYLYKHG.YFYPPLKRFAFP.SSSDSSEENGNG.DNSEEEEEEEET....SNEEEN.N...ED...SNGNEGEESEA..ENTTLST...ATP...........GYGEEITAG.....TEYIG.LAA.IRLPK.....................KlygTKFIRHPCIKAQDRGAHAEAPE.......CSPAIGEAEVDGNEQVVNGT..S.....TNSTE.....LETSTGSSGADN..GE......EGEAEGTT---.AGATLTVGQ.TTGSSHTTPSPDAGFE...PTNQTP.E.A-----.----KTTTAEYGGEY..........E..QTGGNEYDPGYDV.....YD.aAENGGPRGDNYRAY....EDEY.SYYKGRGYEGYEGQDYY............................
F7I6C9_CALJA/17-146                 ........................FSMKNLHRRVKIEDSEENGVFK..YRP..RYYLYKHA.YFYPPLKRFPVQqGNSDSSEENGD-.DSSEEEEEEEGA....SNEEEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDATPG.....TGYTG.LAA.IQLPK.....................K...AGYITNKAM-------------.......--------------------..-.....-----.....------------..--......-----------.---------.----------------...------.-.------.---------------..........-..-------------.....--..--------------....----.-----------------d...........................
SIAL_PIG/1-300                      ........................FSMKNFHRRAKLEDPEENGVFK..YRP..RYYLYKHA.YFYPPLKRFPVQ.SSSDSSEENGNG.DSSEEEEEEEEN....SNEEEN.N...EEnedSDGNEDEDSEA..ENITLST...TTL...........GYGGDVTPG.....TASIG.LAA.LQLPK.....................K...AGDIGKKSAKEEESDEDEEEEE.......-ENEENEAEVDDNEQGTNGT..S.....TNSTE.....VDSGNGHSGGDN..GE......EGDQESVTEA-.QGTTVAGEQ.DNGGAKTTTSPNGGLE...PTPPPQ.D.ISGTTL.PPSGKTTTPEYEGEY..........E..QTGAHEYDNGYEI.....YE..SENGEPRGDSYRAY....EDEY.SYYKGRSYNSYGGHDYY............................
H3ALZ7_LATCH/19-308                 ....................ayrr------YRKAKADDSDENGVTKnnHRH..RYYVYKYV.YMNSPQKHAAAQ.KNVDSSEENGD-.DSSNELETKKEG....DSEEDNgN...GNn.nSNGNEEDDNGG..ENGDGGN...GN-...........GYDEDN--G.....KNH--.-RQ.VKYKT.....................K...IEVGRKYITQNKDRGDDHDDYG.......-DNGNHGRNGDNGNYGHNGN..Y.....GHHGD....nGVNGNGENGGED.nGD......DSNGENGGEH-.NGD--VSNG.ENGGEHNGYGSNG---...ENAGEH.N.GYGSNG.ENAGEDNEQENNADY..........N..KGSEDNGENGDEE.....YE.dNDNGE-NGDGYRYIngenEEDYdEHYNGYAYH--------gny.........................
K7GP14_PIG/17-316                   ........................FSMKNFHRRAKLEDPEENGVFK..YRP..RYYLYKHA.YFYPPLKRFPVQ.SSSDSSEENGNG.DSSEEEEEEEEN....SNEEEN.N...EEnedSDGNEDEDSEA..ENITLST...TTL...........GYGGDVTPG.....TASIG.LAA.LQLPK.....................K...AGDIGKKSAKEEESDEDEEEEE.......-ENEENEAEVDDNEQGTNGT..S.....TNSTE.....VDSGNGHSGGDN..GE......EGDQESVTEA-.QGTTVAGEQ.DNGGAKTTTSPNGGLE...PTPPPQ.D.ISGTTL.PPSGKTTTPEYEGEY..........E..QTGAHEYDNGYEI.....YE..SENGEPRGDSYRAY....EDEY.SYYKGRSYNSYGGHDYY............................
W4W7I7_ATTCE/9-123                  .....................scq------------------AVFR..QRSnrRKLVVDRL.LFYPSNSEIDVR.TVTFFSFDDEDG.TDDDDDDDDDDD....DDDDDD.D...DD...DDNDDDDDDDD..DATTTTT...TTT...........TT-------.....-----.---.-----.....................-...----------------------.......--------------------..-.....-----.....------------..--......-----------.---------.----------------...------.-.------.---------------..........-..-------------.....--..--------------....----.-----------------marrvgharffarrstsfdrarnymtl.
SIAL_MOUSE/17-321                   ........................FSMKNFHRRIKAEDSEENGVFK..YRP..RYFLYKHA.YFYPPLKRFPVQ.GGSDSSEENGDG.DSSEEEGEEEET....SNEEEN.N...ED...SEGNEDQEAEA..ENSTLSTlsgVTA...........SYGAETTPQ.....AQTFE.LAA.LQLPK.....................K...AGDAESRAPKVKESDEEEEEEEe.....eEENENEEAEVDENELAVNGT..S.....TNSTE.....VDGGNGSSGGDN..GEe....aEAEEASVTEAGaEGTTGGREL.TSVGTQTAVLLNG-FQ...QTTPPP.E.AYGTTS.PPIRKSSTVEYGGEY..........E..QTGN-EYNNEYEV.....YD..NENGEPRGDTYRAY....EDEY.SYYKGHGYEGYEGQNYY............................
U3I5J6_ANAPL/5-64                   .....................war----------------------..---..--------.------------.------------.------------....------.-...--...-----------..-------...---...........---------.....-----.---.-----.....................-...----------------------.......--------------------..-.....-----.....------------..--......-----------.---------.----------------...------.-.------.----------RQWQY..........E..VQTQFCGDEGPTEg...sYG..DHEGYARGDSYRAY....EDEY.GYYKGHGYDVY-GQDYY............................
G5BSU4_HETGA/17-316                 ........................LSMKNLHRRFKLEDSEENGVFK..YRP..RYYLYKHG.YFYPPLKQFAVQ.GNSDSSEENGNG.DSSEEEEEEDET....SNEEEN.N...ED...SNGNEDEDSEA..ENTTLST...ITP...........GYGEETTPG.....TDYIG.LAA.IQLPK.....................K...AGDIGNKATKKEESDEEEEEEE.......NENENNEAEVDGNEQAVNGT..S.....TNSTE.....VENGNGSSGADN..GE......EGDKESVTEANtPGTTMSAGQ.STGSSKTTPSPNGVFE...PTTPAP.E.VYGSTP.PPYGKTTTAEYGAEY..........E..QTGANEYDPGYEV.....YD..NENGGPRGDNYRAY....EDEY.SYYKGRGYDGYDGQDYY............................
U3I5J2_ANAPL/139-208                ...................ngtaa----------------------..---..--------.------------.------------.------------....------.-...--...-----------..-------...---...........---------.....-----.---.-----.....................-...----------------------.......--------------------..-.....-----.....------------..--......-----------.---------.----------------...------.-.------.EP--EATTVAATTGL..........D..EATTAXGDEGPTEg...sYG..DHEGYARGDSYRAY....EDEY.GYYKGHGYDVY-GQDYY............................
#=GC seq_cons                       ........................hShKshhRRhKh-DSEENuVFK..aRs..RYYLYKau.YhYPsLKRasVQ..sSDSSEEsGst.-SSEEEEEpE-s....sNEtts.N...E-.....tsE-p-uEu..EssTLSs...sT............uYGpp.Tsu.....st.hG.LAA.lphPK.....................K...sGshtp+uscpc-uDE-EEEEE........EpEEpEAEVDENcQGlNGT..S.....oNSTE.....s-sGNGsuGGDs..tE......EsEEEs.stt..tsps.sttp.ttss.toTssssG.hp...sTTPs....hYtsTs..s.tcsTTst.ttEY..........E...TusscYDsGYEl.....Y-..sENG-PRGDsYRAY....EDEY.SYYKGpGY-uYtGQsYY............................
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