GenomeNet

Database: Pfam
Entry: BSP_II
LinkDB: BSP_II
Original site: BSP_II 
#=GF ID   BSP_II
#=GF AC   PF05432.6
#=GF DE   Bone sialoprotein II (BSP-II)
#=GF AU   Moxon SJ
#=GF SE   Pfam-B_12103 (release 8.0)
#=GF GA   25.00 25.00;
#=GF TC   25.00 40.00;
#=GF NC   24.90 24.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   8061918
#=GF RT   Characterization of the human bone sialoprotein (BSP) gene and
#=GF RT   its promoter sequence. 
#=GF RA   Kim RH, Shapiro HS, Li JJ, Wrana JL, Sodek J; 
#=GF RL   Matrix Biol 1994;14:31-40.
#=GF RN   [2]
#=GF RM   10785518
#=GF RT   Expression of bone sialoprotein in mineralized tissues of tooth
#=GF RT   and bone and in buccal-pouch carcinomas of Syrian golden
#=GF RT   hamsters. 
#=GF RA   Sasaguri K, Ganss B, Sodek J, Chen JK; 
#=GF RL   Arch Oral Biol 2000;45:551-562.
#=GF DR   INTERPRO; IPR008412;
#=GF CC   Bone sialoprotein (BSP) is a major structural protein of the
#=GF CC   bone matrix that is specifically expressed by
#=GF CC   fully-differentiated osteoblasts [1]. The expression of bone
#=GF CC   sialoprotein (BSP) is normally restricted to mineralised
#=GF CC   connective tissues of bones and teeth where it has been
#=GF CC   associated with mineral crystal formation. However, it has been
#=GF CC   found that ectopic expression of BSP occurs in various lesions,
#=GF CC   including oral and extraoral carcinomas, in which it has been
#=GF CC   associated with the formation of microcrystalline deposits and
#=GF CC   the metastasis of cancer cells to bone [2]. 
#=GF SQ   53
#=GS F6TZH2_MACMU/17-315   AC F6TZH2.1
#=GS SIAL_CHICK/17-273     AC P79780.1
#=GS F1NSM6_CHICK/17-290   AC F1NSM6.1
#=GS F7EC59_ORNAN/17-303   AC F7EC59.1
#=GS Q3TRM5_MOUSE/17-321   AC Q3TRM5.1
#=GS A0JPM6_RAT/17-316     AC A0JPM6.1
#=GS F7EC69_ORNAN/17-295   AC F7EC69.1
#=GS H0YVI3_TAEGU/17-86    AC H0YVI3.1
#=GS F7G8V1_MONDO/17-304   AC F7G8V1.1
#=GS F7EC51_ORNAN/17-295   AC F7EC51.1
#=GS F7EC64_ORNAN/17-303   AC F7EC64.1
#=GS D2GX57_AILME/17-317   AC D2GX57.1
#=GS H0YVI3_TAEGU/85-287   AC H0YVI3.1
#=GS F7I6C9_CALJA/142-291  AC F7I6C9.1
#=GS G1N6F0_MELGA/165-259  AC G1N6F0.2
#=GS F7I699_CALJA/17-314   AC F7I699.1
#=GS G3VPY7_SARHA/17-313   AC G3VPY7.1
#=GS SIAL_BOVIN/17-307     AC Q28862.1
#=GS G1KML5_ANOCA/17-311   AC G1KML5.1
#=GS G3TER7_LOXAF/17-319   AC G3TER7.1
#=GS G3SAN1_GORGO/17-301   AC G3SAN1.1
#=GS G1SEM1_RABIT/17-312   AC G1SEM1.1
#=GS G3QVT7_GORGO/61-294   AC G3QVT7.1
#=GS G3ILN2_CRIGR/17-312   AC G3ILN2.1
#=GS E7D7Z0_CERNI/17-308   AC E7D7Z0.1
#=GS G7P5V9_MACFA/4-286    AC G7P5V9.1
#=GS Q3HLN4_RAT/17-316     AC Q3HLN4.1
#=GS G7MTD4_MACMU/17-315   AC G7MTD4.1
#=GS H2PDV2_PONAB/17-314   AC H2PDV2.1
#=GS F1RW36_PIG/17-316     AC F1RW36.1
#=GS G1PF90_MYOLU/17-305   AC G1PF90.1
#=GS F7EC55_ORNAN/17-303   AC F7EC55.1
#=GS SIAL_HUMAN/17-314     AC P21815.4
#=GS H2QPV2_PANTR/17-314   AC H2QPV2.1
#=GS B3SXQ5_PALPA/17-334   AC B3SXQ5.1
#=GS G1REL7_NOMLE/17-314   AC G1REL7.1
#=GS F6YPI2_HORSE/17-308   AC F6YPI2.1
#=GS P70113_MESAU/17-313   AC P70113.1
#=GS H0X499_OTOGA/17-308   AC H0X499.1
#=GS F1RW45_PIG/1-299      AC F1RW45.1
#=GS G1N6F0_MELGA/17-181   AC G1N6F0.2
#=GS SIAL_RAT/17-317       AC P13839.1
#=GS F6TAB6_CHICK/17-273   AC F6TAB6.1
#=GS F7ANQ5_MONDO/177-281  AC F7ANQ5.1
#=GS G3QVT7_GORGO/17-63    AC G3QVT7.1
#=GS H0VK51_CAVPO/17-307   AC H0VK51.1
#=GS F7I6C9_CALJA/17-146   AC F7I6C9.1
#=GS SIAL_PIG/1-300        AC P31936.2
#=GS H3ALZ7_LATCH/19-308   AC H3ALZ7.1
#=GS E2RPB1_CANFA/17-322   AC E2RPB1.1
#=GS SIAL_MOUSE/17-321     AC Q61711.2
#=GS F7ANQ5_MONDO/17-192   AC F7ANQ5.1
#=GS G5BSU4_HETGA/17-316   AC G5BSU4.1
F6TZH2_MACMU/17-315              .........................FSMKNLHRRVKIEDSEENGVFK..YRPRYYLYKHA.YFYPPLKRFPVQGS.SDSSEENGDDS.S.EEEEEE.EE..TSNE.GEN.....NEE...S--..NE..DED..SEA..ENTTLSA...TTLGY.GE.DATPGTWYTGL.A.AI......QLPKKA.GD..VTNK.ATKK.EESD.E......E..EEEEEe...eNENEESEAE.VDENEQGINGTSTNST.EA..ENGNGSSGG.........DNGEE.eGEE.ESVTGASAEGT..TATggqgkgsSKTTTSPNGGFEPTTPPP.-V...YRTTSL..PFGKTTTVEYEG.EYEYT...GANEYDNGYEV.....YE.SENGEP.RGDNYRAYEDEYS..Y...FKGQGYDSYDGQNYY...........
SIAL_CHICK/17-273                .........................FSVRSWLRRARAGDSEENAVLK..SRHRYYLYRYA.--YPPLHRY---KG.SDSSEEEGDGS.E.EEEEGG.AP..----.---.....---...--S..HA..GTQ..AAG..EGLTLGD...V--GP.GG.DA---------.A.SA......HQDCKG.G-..--QK.GTRG.DSGD.E......D..SDEEEe...eEEEEEEEEE.VEEQDVSVNGTSTNTTaET..PHGNNTVAAee.....eeDDDEE..EEE.EEEEEEEAEAT..TAA.......------------ATTAQD.EV...TTLGDE..QRSEVTTAGEQW.EYEVT..vGARGDEGPTES.....SY.GDQEEPaRGDSYRAYEDEYG..Y...YKGHGYDMY-GQDYY...........
F1NSM6_CHICK/17-290              .........................FSVRSWLRRARAGDSEENAVLK..SRHRYYLYRYA.--YPPLHRY---KG.SDSSEEEGDGS.E.EEEEGG.VS..MGLQ.RAAiqglaSEP...SYS..FL..GTQ..AAG..EGLTLGD...V--GP.GG.DA---------.A.SA......HQDCKG.G-..--QK.GTRG.DSGD.E......D..SDEEEe...eEEEEEEEEE.VEEQDVSVNGTSTNTTaET..PHGNNTVAAee.....eeDDDEE..EEE.EEEEEEEAEAT..TAA.......------------ATTAQD.EV...TTLGDE..QRSEVTTAGEQW.EYEVT..vGARGDEGPTES.....SY.GDQEEPaRGDSYRAYEDEYG..Y...YKGHGYDMY-GQDYY...........
F7EC59_ORNAN/17-303              .........................FSVKNLHRRAKVEESEENAVFK..HRPRYYIYKYA.YLYPPQKRILSQGQ.SVLSPETSPGT.A.SRDDGE.ND.eTSNE.EN-.....EE-...-NE..EE..DEN..SEG.eESTTVSA...TTPLY.GE.ETTPGRGDNGL.G.AI......KVPKKN.GD..VQNT.GMAN.KMKHiE......N..LTAETr..ksNENEESEAE.VEENEQGINGTSTNST.ED..SGNDGGENG.........GEAAE..EEE.ESVTEANQEEN..GG-.......QETTTFVDSVQGATTPSN.GA...YEVTTP..P----TTS---N.GYEET...VTNEYDSGYEV.....YE.NENAEP.RGDNFRTYEDEYS..N...YKGRGYDGYDGRDYY...........
Q3TRM5_MOUSE/17-321              .........................FSMKNFHRRIKAEDSEENGVFK..YRPRYFLYKHA.YFYPPLKRFPVQGG.SDSSEENGDGD.S.SEEEGE.EE.eTSNE.EEN.....NED...SEG..NE..DQE..AEA..ENSTLSTlsgVTASY.GA.ETTPQAQTFEL.A.AL......QLPKKA.GD..TESR.APKV.KESD.E......E..EEEEEe...eEENENEEAE.VDENELAVNGTSTNST.EV..DGGNGSSGG.........DNGEEaeAEE.ASVTEAGAEGT..TGGrel.tsvGTQTAVLLNGFQQTTPPP.EA...YGTTSP..PIRKSSTVEYGG.EYEQT...G-NEYNNEYEV.....YD.NENGEP.RGDTYRAYEDEYS..Y...YKGHGYEGYEGQNYY...........
A0JPM6_RAT/17-316                .........................FSMKNFHRRIKAEDSEENGVFK..YRPRYFLYKHA.YFYPPLKRFPVQGG.SDSSEENGDGD.S.SEEEGE.EE.eTSNE.EEN.....NED...SEG..NE..DQE..AEA..ENATLSG...VTASY.GV.ETTADAGKLEL.A.AL......QLPKKA.GD..AEGK.APKM.KESD.E......E..EEEEE....eEENENEEAE.VDENEQVVNGTSTNST.EV..DGGNGPSGG.........DNGEE..AEE.ASVTEAGAEGT..TAGareltsyGTTTAVLLNGFQQTTPPP.EA...YGTTSP..PARKSSTVEYGE.EYEQI...G-NEYNTAYET.....YD.ENNGEP.RGDTYRAYEDEYS..Y...YKGHGYEGYEGQDYY...........
F7EC69_ORNAN/17-295              .........................FSVKNLHRRAKVEESEENAVFK..HRPRYYIYKYA.YLYPPQKRILSQGG.NSKL---GEQL.E.RDDGEK.RE..TSNE.ENE.....--E...-NE..EE..DEN..SEG.eESTTVSA...TTPLY.GE.ETTPGRGDNGL.G.AI......KVPKKA.E-..-TRK.STKK.EESD.E......E..EEEEEe...eNENEESEAE.VEENEQGINGTSTNST.ED..SGNDGGENG.........GEAAE..EEE.ESVTEANQEEN..GG-.......QETTTFVDSVQGATTPSN.GA...YEVTTP..P----TTS---N.GYEET...VTNEYDSGYEV.....YE.NENAEP.RGDNFRTYEDEYS..N...YKGRGYDGYDGRDYY...........
H0YVI3_TAEGU/17-86               .........................FSVKNWLLRPRLDDSEENAVFK..RQHRHYLYKYI.YVYSPQRRY---QG.SDSSEEEGDGS.E.EEGEGG.LP..----.---.....---...---..--..---..---..-------...-----.--.-----------.-.--......------.--..----.----.----.-......-..-----.....---------.----------------.--..---------.........-----..---.-----------..---.......------------------.--...------..------------.-----...-----------.....--.------.-------------..-...---------------raamtl.....
F7G8V1_MONDO/17-304              .........................FSAKHLYRRAKLEDSEENGVFN..HRHRYYLNKYS.YFYPPLKRIPVQHN.GDSSEE-GDGD.S.SEEEEE.EE.eTSNE.EES.....ETN...GS-..ED..EEE..EGG..ESTTLSA...TTSGY.EE.ENTTASGDVGL.A.AI......QIPKKG.E-..DSKN.NTKK.EESD.E......E..EEEEEe...eEENKESEAE.VDKNKEVVNGTD----.-H..GDGNGTSGK.........EDGEE..EEEvENGTESSVDKD..NNS.......TELATSPNSRYESTTPLE.GT...YEVTSP..PYEESTSNLYDS.GYEEP...VTNEYDNGYEI.....YE.NENGEP.RGDNYRAYEDEYS..Y...YKGHPYNGYEGQDYY...........
F7EC51_ORNAN/17-295              .........................FSVKNLHRRAKVEESEENAVFK..HRPRYYIYKYA.YLYPPQKRILSQVN.SFHLRENIERD.D.GEKRVQ.EE..TSNE.ENE.....--E...-NE..EE..DEN..SEG.eESTTVSA...TTPLY.GE.ETTPGRGDNGL.G.AI......KVPKKV.TH..TLHS.QIPE.AETR.K......S..TKN--.....-ENEESEAE.VEENEQGINGTSTNST.ED..SGNDGGENG.........GEAAE..EEE.ESVTEANQEEN..GG-.......QETTTFVDSVQGATTPSN.GA...YEVTTP..P----TTS---N.GYEET...VTNEYDSGYEV.....YE.NENAEP.RGDNFRTYEDEYS..N...YKGRGYDGYDGRDYY...........
F7EC64_ORNAN/17-303              .........................FSVKNLHRRAKVEESEENAVFK..HRPRYYIYKYA.YLYPPQKRILSQGS.IPSSQERDDGE.K.EGEIDI.NE..TSNE.ENE.....--E...-NE..EE..DEN..SEG.eESTTVSA...TTPLY.GE.ETTPGRGDNGL.G.AI......KVPKKN.GD..VQNT.GMAN.KMKHiE......N..LTAETrk.stNENEESEAE.VEENEQGINGTSTNST.ED..SGNDGGENG.........GEAAE..EEE.ESVTEANQEEN..GG-.......QETTTFVDSVQGATTPSN.GA...YEVTTP..P----TTS---N.GYEET...VTNEYDSGYEV.....YE.NENAEP.RGDNFRTYEDEYS..N...YKGRGYDGYDGRDYY...........
D2GX57_AILME/17-317              .........................FSMKNLHRRAKLEDSEENGVFK..YRPRYSLYKHA.YFYPPLKRFPVQSS.SDSSEEDGNGD.S.SEEEEE.EE.eTSNE.EENn..eeNAN...SDE..NE..DEE..SEA..ENTTLTA...T-PGY.GE.ETTPGTGYIGL.A.AI......QLPKKS.GD..IGHK.ATKE.EESD.E......E..EEEDE.....-ENEENEAE.VDENGQGINGTSSNST.EA..ENGNGSSDG.........DNGEE..GEE.ESVTEAHTEGT..TVVgkqdnggSKTTVSPDGGFERTTPPP.EL...YGTTTR..PSGEATPTGYEG.EYEQT...GTNEYDNGYEV.....YE.NENGEP.RGDNYRAYEDEYS..Y...YKGRSYDGYDGQDYY...........
H0YVI3_TAEGU/85-287              tltsglllpmadcwgvghpagvspe----------------------..-----------.--------------.-----------.-.------.--..----.---.....---...---..--..---..---..-------...-----.--.-----------.-.--......--DCQG.AL..TGDR.TANK.EEDS.E......N..EDSDE.....NEEEEEDEE.VDENENGVNGTSTNTT.EGigPHGNGTVVAee.....atEEEEE..EEE.EEEEEEEAEAT..TIA.......---STTNEEGLTQATTMD.D-...-GGPTD..ATTDATTAGELW.EYDVTardHSRGEEGTTEG.....GY.EEQDEYaRGDSYRAYEDEYG..Y...YKGHGYDVY-GQDYY...........
F7I6C9_CALJA/142-291             ......................nka----------------------..-----------.--------------.-----------.-.------.--..----.---.....---...---..--..---..---..-------...-----.--.-----------.-.--......------.--..----.----.----.-......-..-----.....---------.MDENEQGINGTSTNST.EA..ENGNGSSGG.........DNGEE.eGEV.ESVTGASAEGT..TATrgqgkstSKTTTSPNGDFEPTTPPQ.P-...YRTTSP..PFGKTTTVEYEG.EYEHT...GTSEYDNGYEV.....YE.SENGEP.RGDSYRAYEDEYS..Y...FKGHGYDGYGGQDYY...........
G1N6F0_MELGA/165-259             .........................----------------------..-----------.--------------.-----------.-.------.--..----.---.....---...---..--..---..---..-------...-----.--.-----------.-.--......------.--..----.----.----.-......-..-----.....---------.----------------.--..---------.........-----..--E.EEEEEEEAEAT..TTA.......------------ATTAQD.EV...TTLGNE..QHSEATTAGEQW.EYEVT..vGARGDEGPTEG.....SY.GDQEGPaRGDSYRAYEDEYG..Y...YKGHGYDIY-GQDYY...........
F7I699_CALJA/17-314              .........................FSMKNLHRRVKIEDSEENGVFK..YRPRYYLYKHA.YFYPPLKRFPVQGN.SDSSEENGDDS.S.EEEEEE.EG..ASNE.EEN.....NEE...S--..NE..DED..SEA..ENTTLSA...TTLGY.GE.DATPGTGYTGL.A.AI......QLPKKA.GY..ITNK.AMKK.KESD.E......E..EEEEE....eEENEESEAE.VDENEQGINGTSTNST.EA..ENGNGSSGG.........DNGEE.eGEV.ESVTGASAEGT..TATrgqgkstSKTTTSPNGDFEPTTPPQ.P-...YRTTSP..PFGKTTTVEYEG.EYEHT...GTSEYDNGYEV.....YE.SENGEP.RGDSYRAYEDEYS..Y...FKGHGYDGYGGQDYY...........
G3VPY7_SARHA/17-313              .........................FSVKNLYRRAKLGDSEENGVLN..HRHRYYIYKYS.YLYPPLKRIPVQRN.GDSSEE-GDGE.S.SEEEEE.EE..DTNRfSKNrl.fnKEN...SNE..EE..ETE..SNGseESTTLSA...TTLGY.GE.ENTTASGDIGL.A.AI......QNPKKP.EE..KNNQ.VTKK.EESD.E......E..EEEEE.....-ENEESEAE.VDENKEGGNSTNHENA.EG..DHGNGNGGK.........EEGEE..EEEvENGTEATENEA..SNS.......TEVTTS-LNGYEFTTLLK.GD...FEVTSP..PYEESTSNLYDS.GYEEP...VTNEYDNGYEV.....YE.NENREP.RGDNYRAYEDEYS..Y...YKGHAYNGYGGQDYY...........
SIAL_BOVIN/17-307                .........................LSMKNLNRRAKLEDSEENGVFK..YRPQYYVYKHG.YFYPALKRFAVQSS.SDSSEENGNGD.S.SEEEEE.EE.eTSNE.EGNn..ggNED...SDE..NE..DEE..SEA..ENTTLST...TTLGY.G-.EITPGTGDIGL.A.AI......WLPRKA.GA..TGKK.ATKE.DESD.E......E..EEEEE.....--EEENEAE.VDDNEQGINGTSSNST.EV..DNGHGSSGG.........DNGEE.dGEE.ESVTEANTEGI..TVA.......GETTTSPNGGFKPTTPHQ.EV...YGTTPP..PFGKITTP---G.EYEQT...GTNEYDNGYEI.....YE.SENGDP.RGDNYRAYEDEYS..Y...YKGRGYDSYDGQDYY...........
G1KML5_ANOCA/17-311              .........................FSVKSFRRRFKADDSEENAVFK..NRFWPFFYRQP.YLYPPMKRQ--QFN.SDSSEEGYGGN.S.SEEEEE.EE.aGPSN.EEN.....EGE...QEK..EE..ATK..APS..EPATGDK...SMQVP.VKkEPLGKPGKEGG.A.KK......AEKDKA.PE..KGGK.EE-E.EDSD.E......N..EEEEN.....EEEENEEQEkVDENGNGVNGTSTNST.AE..ENGNGGKGE.........EEEEE..EEN.EATTIVPTTLF..TTV.......V-PTTEYQDQYDTTTEEQwHA...ETTPED..QWQYDTTTEDPW.VHDTT...TTTGYENGYETqt.dyYG.SENGYP.RGDTFRAYEDEYS..Y...YKGHGYDVY-GQDYY...........
G3TER7_LOXAF/17-319              .........................FSMKNLHRRAKLEDSEENRVFK..FRPQYYLYKHA.YFYPPQKRFPVLSN.SDSSEENGDGY.S.SEEEEE.EE.eSSNE.GENn..eeNEE...SNE..NE..EEE..SEA..ENTTLST...ATPGY.GE.ETTPGTGSLGL.A.AI......QLPKKA.KV..IPTL.NVPSlVQSH.F......R..EENSK.....IEKVSRKAE.VDENEQGINGTSTNST.DT..ENGNGSNGG.........DHGEE.eGEE.ESVTEANAEEA..TVTgeqgnggLETTASPNAGFQPTAPPQ.DI...YGTTTP..PFGEITTTG--Y.EYEQT...GTNEYDNGYEV.....YE.NENGEP.RGDNYRAYEDEYS..Y...YKGRSYDGYDGQDYY...........
G3SAN1_GORGO/17-301              .........................FSMKNLHRRVKIEDSEENGVFK..YRPRYYLYKHA.YFYPHLKRFPVQGN.KDSSQEHTHTT.HtSLKRGE.VK.eTSNE.GEN.....NEE...S--..NE..DED..SEA..ENTTLSA...TTLGY.GE.DATPGTGYAGL.A.AI......QLPKKA.GD..ITNK.ATKE.KES-.-......-..-----.....-----GEAE.VDENEQGINGTSTNST.EA..ENGNGSSGG.........DNGEE..GEE.ESVTGANAEGT..TETggqgkgtSKTTTSPNGGFEPTTPPQ.-V...YRTTSP..PFGKITTVEYEG.EYEYT...GANEYDNGYEI.....YE.SENGEP.RGDNYRAYEDEYS..Y...FKGQGYDGYDGQNYY...........
G1SEM1_RABIT/17-312              .........................FSMKNLHRRVKLQDSEENGVFK..FRPQYYLYKHA.YFYPPLKRFPVPDS.SDSSEENGEGD.S.SDEEEEgEE..TSNE.EEN.....NED...SNG..NE..DEE..SEA..ENSTLSF...TTPDY.G-.EITRGTGYIGL.A.GI......KLPKKK.IL..GEQL.GTDK.QVLR.DgitfqiP..RQKEN.....DAYNKRAGA.IENKEQSINGTSSNST.EA..ENGEAGEGE.........SVT--..ATD.AAGTATRGEWI..SRA.......AETTTAPSGGFEPTTPPP.EA...YGTTSP..PFGKTTAAEYGG.EYEQT...GNHGYDDGYEI.....YE.NENGDP.RGDNYRAYEDEYS..Y...YKGRGYEGYEGQDYY...........
G3QVT7_GORGO/61-294              ........................q----------------------..-----------.--------------.-----------.-.------.EE..TSNE.GEN.....NEE...S--..NE..DED..SEA..ENTTLSA...TTLGY.GE.DATPGTGYAGL.A.AI......QLPKKA.GD..ITNK.ATKE.KESD.E......E..EEEEEe...eNENEESEAE.VDENEQGINGTSTNST.EA..ENGNGSSGG.........DNGEE..GEE.ESVTGANAEGT..TETggqgkgtSKTTTSPNGGFEPTTPPQ.-V...YRTTSP..PFGKITTVEYEG.EYEYT...GANEYDNGYEI.....YE.SENGEP.RGDNYRAYEDEYS..Y...FKGQGYDGYDGQNYY...........
G3ILN2_CRIGR/17-312              .........................FSMKNLHRRVKAEDSEENGVFK..YRPRYFLYKHA.YFYPPLKRFPVQGG.SDSSEENGDGD.S.SDEEGE.EE..TSNE.EEN.....NED...SEG..NE..DEE..AEA..GNTTLSS...VTASY.GA.ETTTEAGSIGL.A.AL......QLPKKA.GD..AESK.AAKN.KESD.E......E..EEEEE.....-ENENEEAE.VEENEQVANGTSANST.EA..YGGNSSSGG.........DNGE-..GEE.QSVTEAGVEGT..TLDreq.isdGPTTAVLPNGFQYTTPPP.EA...YGTTAP..PFRKPTTAEYWG.EYEQT...GNNEDNGEYQI.....YD.NENGEP.RGDTYRAYEDEYS..Y...YKGRGYEGYDGQDYY...........
E7D7Z0_CERNI/17-308              .........................LSMKNLHQRAKLEDSEENGVFK..YRPRYYLYKHA.YFYPALKRFAVQSS.SDSSEENGNGD.S.SEEEEE.EE.eTSNE.EGNn..ggNED...SDE..NE..DEE..SEA..ENATLST...TTLGY.GE.EITPGTGHIGL.A.AI......RLPKKA.GA..TGKK.ATEE.DESD.E......E..EEEEE.....--EEENEAE.VDDNEQGINGTSSNST.EV..DNGHGSSGG.........DNGEE.eGEE.ESVTEANTEGT..AVA.......GETTISPNGGFKSTTPPQ.EV...YGTTPP..LFGKTTTP---G.EYEQT...GTNEYDNGYEI.....YE.SENGDP.RGDSYRAYEDEYS..Y...YKGRGYDSYDGQDYY...........
G7P5V9_MACFA/4-286               .......................af------------------SVFK..YRPRYYLYKHA.YFYPPLKRFPVQGS.SDSSEENGDDS.S.EEEEEE.EE..TSNE.GEN.....NEE...S--..NE..GED..SEA..ENTTLSA...TTLGY.GE.DATPGTWYTGL.A.AI......QLPKKA.GD..VTNK.ATKK.EESD.E......E..EEEEEe...eNENEESEAE.VDENEQGINGTSTNST.EA..ENGNGSSGG.........DNGEE.eGEE.ESVTGASAEGT..TATggqgkgsSKTTTSPNGGFEPTTPPP.-V...YRTTSL..PFGKTTTVEYEG.EYEYT...GANEYDNGYEV.....YE.SENGEP.RGDNYRAYEDEYS..Y...FKGQGYDSYDGQNYY...........
Q3HLN4_RAT/17-316                .........................FSMKNFHRRIKAEDSEENGVFK..YRPRYFLYKHA.YFYPPLKRFPVQGG.SDSSEENGDGD.S.SEEEGE.EE.eTSNE.EEN.....NED...SEG..NE..DQE..AEA..ENATLSG...VTASY.GV.ETTADAGKLEL.A.AL......QLPKKA.GD..AEGK.APKM.KESD.E......E..EEEEE....eEENENEEAE.VDENEQVVNGTSTNST.EV..DGGNGPSGG.........DNGEE..AEE.ASVTEAGAEGT..TAGvreltsyGTTTAVLLNGFQQTTPPP.EA...YGTTSP..PARKSSTVEYGE.EYEQI...G-NEYNTAYET.....YD.ENNGEP.RGDTYRAYEDEYS..Y...YKGHGYEGYEGQDYY...........
G7MTD4_MACMU/17-315              .........................FSMKNLHRRVKIEDSEENGVFK..YRPRYYLYKHA.YFYPPLKRFPVQGS.SDSSEENGDDS.S.EEEEXX.XE..TSNE.GEN.....NEE...S--..NE..DED..SEA..ENTTLSA...TTLGY.GE.DATPGTWYTGL.A.AI......QLPKKA.GD..VTNK.ATKK.EESD.E......E..EEEEEe...eNENEESEAE.VDENEQGINGTSTNST.EA..ENGNGSSGG.........DNGEE.eGEE.ESVTGASAEGT..TATggqgkgsSKTTTSPNGGFEPTTPPP.-V...YRTTSL..PFGKTTTVEYEG.EYEYT...GANEYDNGYEV.....YE.SENGEP.RGDNYRAYEDEYS..Y...FKGQGYDSYDGQNYY...........
H2PDV2_PONAB/17-314              .........................FSMKNLHRRVKIEDSEENGVFK..YRPRYYLYKHA.YFYPHLKRFPVQGS.SDSSEENGDDS.S.EEEEEE.EE..TSNE.GEN.....NEE...S--..NE..DED..SEA..ENTTLSA...TTLGY.GE.DATLATGYPGL.A.AI......QLPKKA.GD..ITSK.ATKE.EESD.E......E..EEEEEe...eNENEESEAE.VDENEQGINGTSTNST.EA..ENGNGSSGG.........DNGEE..GEE.ESVTGANAEGT..TATggqgkgsSKTTTSPNGGFEPTTPPQ.-V...YRTTSP..PFGKTTTVEYEG.EYEYT...GANEYDNGYEI.....YE.SENGEP.RGDNYRAYEDEYS..Y...FKGQGYDGYDGQNYY...........
F1RW36_PIG/17-316                .........................FSMKNFHRRAKLEDPEENGVFK..YRPRYYLYKHA.YFYPPLKRFPVQSS.SDSSEENGNGD.S.SEEEEE.EE.eNSNE.EENn..eeNED...SDG..NE..DED..SEA..ENITLST...TTLGY.GG.DVTPGTASIGL.A.AL......QLPKKA.GD..IGKK.SAKE.EESD.E......D..EEEEE.....-ENEENEAE.VDDNEQGTNGTSTNST.EV..DSGNGHSGG.........DNGEE..GDQ.ESVTEA--QGT..TVAgeqdnggAKTTTSPNGGLEPTPPPQ.DI...SGTTLP..PSGKTTTPEYEG.EYEQT...GAHEYDNGYEI.....YE.SENGEP.RGDSYRAYEDEYS..Y...YKGRSYNSYGGHDYY...........
G1PF90_MYOLU/17-305              .........................FSMKNFHRRAKLEDSEENGVFK..YRPRYYLYKHA.YFYPPLKRFPVQN-.SDSSEENGDGD.S.SEEEEG.EE.eNSNE.EAN.....NEE...S--..NE..DEE..SEA..ENSTLSA...TTPGY.GE.ETTPGTGNVGL.A.AI......QLPKKA.GD..VGKK.ATKK.EESE.E......E..EEEEEe..eeNENEENEAE.VDENGQGVNGTSTNST.DV..ENGNGSSGG.........DNGEE..EEE.EGEEET-AEGT..TVA.......GE---QDNGGFEPTTPPQ.EV...YGTTPP..PQGGTTTTEYEG.EYEQT...GTNEYDNGYEV.....YE.NENAEP.RGDNYRAYEDEYS..Y...YKGRGYDSYDGQNYY...........
F7EC55_ORNAN/17-303              .........................FSVKNLHRRAKVEESEENAVFK..HRPRYYIYKYA.YLYPPQKRILSQVN.SFHLSENSNLEcN.SEDFSS.QE..TSNE.ENE.....--E...-NE..EE..DEN..SEG.eESTTVSA...TTPLY.GE.ETTPGRGDNGL.G.AI......KVPKKN.GD..VQNT.GMAN.KMKHiE......N..LTAETr..ksNENEESEAE.VEENEQGINGTSTNST.ED..SGNDGGENG.........GEAAE..EEE.ESVTEANQEEN..GG-.......QETTTFVDSVQGATTPSN.GA...YEVTTP..P----TTS---N.GYEET...VTNEYDSGYEV.....YE.NENAEP.RGDNFRTYEDEYS..N...YKGRGYDGYDGRDYY...........
SIAL_HUMAN/17-314                .........................FSMKNLHRRVKIEDSEENGVFK..YRPRYYLYKHA.YFYPHLKRFPVQGS.SDSSEENGDDS.S.EEEEEE.EE..TSNE.GEN.....NEE...S--..NE..DED..SEA..ENTTLSA...TTLGY.GE.DATPGTGYTGL.A.AI......QLPKKA.GD..ITNK.ATKE.KESD.E......E..EEEEEe...gNENEESEAE.VDENEQGINGTSTNST.EA..ENGNGSSGG.........DNGEE..GEE.ESVTGANAEDT..TETgrqgkgtSKTTTSPNGGFEPTTPPQ.-V...YRTTSP..PFGKTTTVEYEG.EYEYT...GANEYDNGYEI.....YE.SENGEP.RGDNYRAYEDEYS..Y...FKGQGYDGYDGQNYY...........
H2QPV2_PANTR/17-314              .........................FSMKNLHRRVKIEDSEENGVFK..YRPRYYLYKHA.YFYPHLKRFPVQGS.SDSSEENGDDS.S.EEEEEE.EE..TSNE.GEN.....NEE...S--..NE..DED..SEA..ENTTLSA...TTLGY.GE.DTTPGTGYTRL.A.AI......HLPKKA.GD..ITNK.ATKE.KESD.E......E..EEEEEe...eNENEESEAE.VDENEQGINGTSTNST.EA..ENGNGSSGG.........DNGEE..GEE.ESVTGANAEGT..TETggqgkgsSKTTTSPNGGFEPTTPPQ.-V...YRTTSP..PFGKTTTVEYEG.EYEYT...GANEYDNGYEI.....YE.SENGEP.RGDNYRAYEDEYS..Y...FKGQGYDGYDGQNYY...........
B3SXQ5_PALPA/17-334              .........................FSIKSFRRRAKSDDSEENAVFK..NRHRYYFYRYA.YVYPPQRRM---QS.SDSSEEEGDGD.S.SDEEEE.EGqeQSNE.GEN.....EGD...ETT..TEapTGKvpVDK..KGFSKGE...TKAPKkGQ.DC-KGPGKEEM.SeALkrggkgKAPEKG.G-..-MSK.GSEN.EDSD.E......N..EEEDN.....-EEEENEEK.VDENGNGINGTSTNTT.EA..ETGNGGNGLgengegngnEGAEEgnEEE.EEEEENETEAM..TVI.......--TTTGDQGLYDTTTTED.EVpydTATTEDevPYDTTTTVDQGGyGYEES...PTPGYENGYESqtdynYG.SENGYP.RGDTYRTYEDEYS..Y...YKGHGYDVY-GHDYY...........
G1REL7_NOMLE/17-314              .........................FSMKNLHRRVKIEDSEENGVFK..HRPRYYLYKHA.YFYPHLKRFPVQGS.SDSSEENGDDS.S.EEEEEE.EE..TSNE.GEN.....NEE...S--..NE..DED..SEA..ENTTLSA...TTLGY.GE.DATPGIGYTGL.A.AI......QLPKKA.GD..ITNK.ATKE.KESD.E......E..EEEEEe...eNENEESEAE.VDENEQGINGTSTNST.EA..ENGNGSSGG.........DNGEE..GEE.ESVTGANAEGT..TATggqgkgsSKTTTSPNGGFEPTTPPQ.-V...YRTISP..PFGKTTTVQYEG.EYEYT...GANEYDDGYEI.....YE.SENGEP.RGDNYRAYEDEYS..Y...FKGQGYDGYDGQNYY...........
F6YPI2_HORSE/17-308              .........................LSMKNLHRRAKLEDSEENGVYK..YRPQYSLYKHA.YFYPPLKRFPVQTS.SDSSEENGDGD.S.SEEEEE.EE.eTSNE.EGNn..geNED...SEG..NE..DEE..SDA..ENTTLST...ITPGY.GE.EPTPGMGNIGL.A.AI......QLPKKA.GD..KGNK.GTKE.EESD.E......E..EEEEE.....DENEENEAE.VDENGQGINGTSSNST.EA..ENGHGSSGG.........DNGEE..EGE.E---EANAEGT..AVPaeqdnagSKTTTSPNGGFAPTTPPQ.EV...YRT---..-----TTTAYEG.EYEQT...GTNEYDNGYEV.....YE.NENGEP.RGDNYRAYEDEYS..Y...YKGRSYDGYDGQDYY...........
P70113_MESAU/17-313              .........................FSMKNFHRRVKAEDSEDNGVFK..YRPRYFLYKHA.YFYPSLKRFSVQGG.SDSSEENGDGD.S.SEEEGE.EE..TSNE.EEN.....NEE...SEG..NE..DEE..AEA..ENTTLSS...VTTSY.GA.ETTTGTGNIGL.A.AL......QLPKKA.GN..AESK.AAKK.KESD.E......E..EEEEE.....-ENENEEAE.VEENEQVTNGTSTNST.EV..YGGNGSSGG.........YNGEE..GEE.QSVTEAGVEGT..TVGreq.isdGPTTAVLMNGFQYTTPPP.EA...YGTTSP..PFRKPTTVEYWG.EYEQT...GNNEYNGEYQI.....YD.NENGEP.RGDNYRAYEDEYS..Y...YKGRGYEGYDGQDYY...........
H0X499_OTOGA/17-308              .........................FSMKNLHRRVKPEDSEENGVFK..YRPRYYLYKHA.YFYPALKRFPVQSS.SDSSEENEDGD.S.SEEEEE.EE.eTSNE.EEK.....DEN...SNG..GR..YLT..REF..KALEKSA...T-MGE.GV.LQVQGHGRMGSeL.SF......CFSFQA.GD..MRKQ.ATKK.EESD.E......E..EEEEEe..eeNENEENEAE.VDENDQGVNGTSTNST.ET..ENGNGSSGG.........DAGEG..GEG.DSVTGE-TAGT..-RG.......--QTTSPNGGFQPTTPPP.EV...YGTPSP..PSGKTTTFEYEE.EYEQT...GTNEYDNGYEV.....YD.SENGEP.RGDTYRAYEDEYS..Y...YKGQSYDGYEGYYY-h..........
F1RW45_PIG/1-299                 ........................q--MKNFHRRAKLEDPEENGVFK..YRPRYYLYKHA.YFYPPLKRFPVQSS.SDSSEENGNGD.S.SEEEEE.EE.eNSNE.EENn..eeNED...SDG..NE..DED..SEA..ENITLST...TTLGY.GG.DVTPGTASIGL.A.AL......QLPKKA.GD..IGKK.SAKE.EESD.E......D..EEEEE.....-ENEENEAE.VDDNEQGTNGTSTNST.EV..DSGNGHSGG.........DNGEE..GDQ.ESVTEA--QGT..TVAgeqdnggAKTTTSPNGGLEPTPPPQ.DI...SGTTLP..PSGKTTTPEYEG.EYEQT...GAHEYDNGYEI.....YE.SENGEP.RGDSYRAYEDEYS..Y...YKGRSYNSYGGHDYY...........
G1N6F0_MELGA/17-181              .........................FSVRSWLRRARAGDSEENAVLK..SRHRYYLYRYA.--YPPLHRYKVGPG.SDSSEEEEDGS.E.EEEDGG.VS.iG-LQ.HAEiqglaSEP...SHSflDE..CTQ..AAG..EGLTPGD...T--EL.GG.DA--ASTHQPC.P.CV......PQGCKG.G-..--QK.GTRG.DSGD.E......D..SDEEE.....EEEEEEEEE.EEEEEEA-EATTTA--.--..---------.........-----..---.-----------..---.......------------------.--...------..------------.-----...-----------.....--.------.-------------..-...---------------at.........
SIAL_RAT/17-317                  .........................FSMKNFHRRIKAEDSEENGVFK..YRPRYFLYKHAtYFYPPLKRFPVQGG.SDSSEENGDGD.S.SEEEGE.EE.eTSNE.EEN.....NED...SEG..NE..DQE..AEA..ENATLSG...VTASY.GV.ETTADAGKLEL.A.AL......QLPKKA.GD..AEGK.APKM.KESD.E......E..EEEEE....eEENENEEAE.VDENEQVVNGTSTNST.EV..DGGNGPSGG.........DNGEE..AEE.ASVTEAGAEGT..TAGvreltsyGTTTAVLLNGFQQTTPPP.EA...YGTTSP..PARKSSTVEYGE.EYEQI...G-NEYNTAYET.....YD.ENNGEP.RGDTYRAYEDEYS..Y...YKGHGYEGYEGQDYY...........
F6TAB6_CHICK/17-273              .........................FSVRSWLRRARAGDSEENAVLK..SRHRYYLYRYA.--YPPLHRY---KG.SDSSEEEGDGS.E.EEEEGG.AP..----.---.....---...--S..HA..GTQ..AAG..EGLTLGD...V--GP.GG.DA---------.A.SA......HQDCKG.G-..--QK.GTRG.DSGD.E......D..SDEEEe...eEEEEEEEEE.VEEQDVSVNGTSTNTTaET..PHGNNTVAAee.....eeDDDEE..EEE.EEEEEEEAEAT..TAA.......------------ATTAQD.EV...TTLGDE..QRSEVTTAGEQW.EYEVT..vGARGDEGPTES.....SY.GDQEEPaRGDSYRAYEDEYG..Y...YKGHGYDMY-GQDYY...........
F7ANQ5_MONDO/177-281             ............dhgdgngtnkdnn----------------------..-----------.--------------.-----------.-.------.--..----.---.....---...---..--..---..---..-------...-----.--.-----------.-.--......------.--..----.----.----.-......-..-----.....---------.----------------.--..---------.........-----..---.-----------..--S.......TELATSPNSRYESTTPLE.GT...YEVTSP..PYEESTSNLYDS.GYEEP...VTNEYDNGYEI.....YE.NENGEP.RGDNYRAYEDEYS..Y...YKGHPYNGYEGQDYY...........
G3QVT7_GORGO/17-63               .........................FSMKNLHRRVKIEDSEENGVFK..YRPRYYLYKHA.YFYPHLKRFPVQE-.-----------.-.------.--..----.---.....---...---..--..---..---..-------...-----.--.-----------.-.--......------.--..----.----.----.-......-..-----.....---------.----------------.--..---------.........-----..---.-----------..---.......------------------.--...------..------------.-----...-----------.....--.------.-------------..-...---------------e..........
H0VK51_CAVPO/17-307              .........................FSMKNLHRRVKLEDSEENGVFK..YRPRYYLYKHG.YFYPPLKRFAFPSS.SDSSEENGNGD.N.SEEEEE.EE.eTSNE.EEN.....NED...SNG..NE..GEE..SEA..ENTTLST...ATPGY.GE.EITAGTEYIGL.A.AI......RLPKKLyGTkfIRHP.CIKA.QDRG.A......H..AEAPE.....CSPAIGEAE.VDGNEQVVNGTSTNST.EL..ETSTGSSGA.........DNGEE..GEA.--------EGT..TAG.......ATLTVGQTTGSSHTTPSP.DAg.fEPTNQT..PEAKTTTAEYGG.EYEQT...GGNEYDPGYDV.....YDaAENGGP.RGDNYRAYEDEYS..Y...YKGRGYEGYEGQDYY...........
F7I6C9_CALJA/17-146              .........................FSMKNLHRRVKIEDSEENGVFK..YRPRYYLYKHA.YFYPPLKRFPVQQGnSDSSEENGDDS.S.EEEEEE.EG..ASNE.EEN.....NEE...S--..NE..DED..SEA..ENTTLSA...TTLGY.GE.DATPGTGYTGL.A.AI......QLPKKA.GY..ITNK.A---.----.-......-..-----.....---------.----------------.--..---------.........-----..---.-----------..---.......------------------.--...------..------------.-----...-----------.....--.------.-------------..-...---------------md.........
SIAL_PIG/1-300                   .........................FSMKNFHRRAKLEDPEENGVFK..YRPRYYLYKHA.YFYPPLKRFPVQSS.SDSSEENGNGD.S.SEEEEE.EE.eNSNE.EENn..eeNED...SDG..NE..DED..SEA..ENITLST...TTLGY.GG.DVTPGTASIGL.A.AL......QLPKKA.GD..IGKK.SAKE.EESD.E......D..EEEEE.....-ENEENEAE.VDDNEQGTNGTSTNST.EV..DSGNGHSGG.........DNGEE..GDQ.ESVTEA--QGT..TVAgeqdnggAKTTTSPNGGLEPTPPPQ.DI...SGTTLP..PSGKTTTPEYEG.EYEQT...GAHEYDNGYEI.....YE.SENGEP.RGDSYRAYEDEYS..Y...YKGRSYNSYGGHDYY...........
H3ALZ7_LATCH/19-308              .....................ayrr------YRKAKADDSDENGVTKnnHRHRYYVYKYV.YMNSPQKHAAAQKN.VDSSEENGDDS.S.NELETK.KE..GDSE.EDNg..ngNNN...SNG..NE..EDD..NGG..ENGDGGN...---GN.GY.DEDNGKNHR--.-.QV......KYKTKI.E-..VGRKyITQNkDRGD.D......H..DDY--.....GDNGNHGRN.GDNGNYGHNGNYGHHGdNG..VNGNGENGG........eDNGDD..SNG.ENGGEHNGDVSngENG.......GEHNGYGSNG--ENAGEH.NG...YGSNGE..NAGEDNEQENNA.DYNKG...SEDNGENGDEE.....YE.DNDNGE.NGDGYRYINGENEedYdehYNGYAYH--------gny........
E2RPB1_CANFA/17-322              .........................FSMKNLHRRAKLEDSEENGVFK..YRPRYYLYKHS.YFYPPLKRFPVQSS.SDSSEEDGDGD.S.SEEEEE.EE.eTSNE.EEN.....NEEnanSDE..NE..D-E..SDA..ENSTLSA...T-PGY.GE.EITPGTGYIGL.A.AI......QLPKKE.I-..YNHP.DTKH.RVFH.I......NllKKQEQvqfphLQIRKDIFP.VDENGQGINSTSSNST.EA..ENGNGSSAG.........DNGE-..GEE.ESVTEAHSEGT..TEAgkqnnggSKTTLSPDGGFEPTTPPP.EL...YGTTTR..PSGEATPNGYEE.EYEQT...GTNEYDNGYEV.....YE.SENGEP.RGDNYRAYEDEYS..Y...YKGHSYDSYDGQDYY...........
SIAL_MOUSE/17-321                .........................FSMKNFHRRIKAEDSEENGVFK..YRPRYFLYKHA.YFYPPLKRFPVQGG.SDSSEENGDGD.S.SEEEGE.EE.eTSNE.EEN.....NED...SEG..NE..DQE..AEA..ENSTLSTlsgVTASY.GA.ETTPQAQTFEL.A.AL......QLPKKA.GD..AESR.APKV.KESD.E......E..EEEEEe...eEENENEEAE.VDENELAVNGTSTNST.EV..DGGNGSSGG.........DNGEEaeAEE.ASVTEAGAEGT..TGGrel.tsvGTQTAVLLNGFQQTTPPP.EA...YGTTSP..PIRKSSTVEYGG.EYEQT...G-NEYNNEYEV.....YD.NENGEP.RGDTYRAYEDEYS..Y...YKGHGYEGYEGQNYY...........
F7ANQ5_MONDO/17-192              .........................FSAKHLYRRAKLEDSEENGVFN..HRHRYYLNKYS.YFYPPLKRIPVQHN.GDSSEE-GDGD.S.SEEEEE.EE.eTSNE.EES.....ETN...GS-..ED..EEE..EGG..ESTTLSA...TTSGY.EE.ENTTASGDVGL.A.AI......QIPKKV.RM..H---.FFQM.DVLE.K......N..NNKKT....tYPKTSSEAE.VDKNKEVVNGTDHGDG.--..---------.........-----..---.-----------..---.......------------------.--...------..------------.-----...-----------.....--.------.-------------..-...---------------ngtnkdnnste
G5BSU4_HETGA/17-316              .........................LSMKNLHRRFKLEDSEENGVFK..YRPRYYLYKHG.YFYPPLKQFAVQGN.SDSSEENGNGD.S.SEEEEE.ED.eTSNE.EEN.....NED...SNG..NE..DED..SEA..ENTTLST...ITPGY.GE.ETTPGTDYIGL.A.AI......QLPKKA.GD..IGNK.ATKK.EESD.E......E..EEEEE.....NENENNEAE.VDGNEQAVNGTSTNST.EV..ENGNGSSGA.........DNGEE..GDK.ESVTEANTPGT..TMSagqstgsSKTTPSPNGVFEPTTPAP.EV...YGSTPP..PYGKTTTAEYGA.EYEQT...GANEYDPGYEV.....YD.NENGGP.RGDNYRAYEDEYS..Y...YKGRGYDGYDGQDYY...........
#=GC seq_cons                    .........................FShKNhHRRsKlEDSEENGVFK..aRPRYYLYKHA.YFYPPLKRFsVQsu.SDSSEEsGDGs.S.pEEEtE.EE..TSNE.cEN.....NE-...Spt..NE..DE-..uEu..ENoTLSs...oT.uY.Gt.-sTsGsG.hGL.A.Al......plPKKu.Gt..htpK.us+p.cESD.E......-..EEEEE.....tENEcpEAE.VDENEQGlNGTSTNST.Es..-sGNGuuGG.........DsGEE..tEE.ESVTEAssEuT..Tss.......scTTssssuGapsTTPsp.ts...YtTTsP..PhtcsTTstYts.EYEpT...GsNEYDsGYEl.....Y-.sENGEP.RGDsYRAYEDEYS..Y...YKG+GYDuY-GQDYY...........
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