GenomeNet

Database: Pfam
Entry: BSP_II
LinkDB: BSP_II
Original site: BSP_II 
#=GF ID   BSP_II
#=GF AC   PF05432.7
#=GF DE   Bone sialoprotein II (BSP-II)
#=GF AU   Moxon SJ
#=GF SE   Pfam-B_12103 (release 8.0)
#=GF GA   25.10 25.10;
#=GF TC   25.40 25.60;
#=GF NC   23.80 23.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   8061918
#=GF RT   Characterization of the human bone sialoprotein (BSP) gene and
#=GF RT   its promoter sequence. 
#=GF RA   Kim RH, Shapiro HS, Li JJ, Wrana JL, Sodek J; 
#=GF RL   Matrix Biol 1994;14:31-40.
#=GF RN   [2]
#=GF RM   10785518
#=GF RT   Expression of bone sialoprotein in mineralized tissues of tooth
#=GF RT   and bone and in buccal-pouch carcinomas of Syrian golden
#=GF RT   hamsters. 
#=GF RA   Sasaguri K, Ganss B, Sodek J, Chen JK; 
#=GF RL   Arch Oral Biol 2000;45:551-562.
#=GF DR   INTERPRO; IPR008412;
#=GF CC   Bone sialoprotein (BSP) is a major structural protein of the
#=GF CC   bone matrix that is specifically expressed by
#=GF CC   fully-differentiated osteoblasts [1]. The expression of bone
#=GF CC   sialoprotein (BSP) is normally restricted to mineralised
#=GF CC   connective tissues of bones and teeth where it has been
#=GF CC   associated with mineral crystal formation. However, it has been
#=GF CC   found that ectopic expression of BSP occurs in various lesions,
#=GF CC   including oral and extraoral carcinomas, in which it has been
#=GF CC   associated with the formation of microcrystalline deposits and
#=GF CC   the metastasis of cancer cells to bone [2]. 
#=GF SQ   75
#=GS M7AV71_CHEMY/343-611     AC M7AV71.1
#=GS I3J5Y8_ORENI/494-621     AC I3J5Y8.1
#=GS F6TZH2_MACMU/17-315      AC F6TZH2.1
#=GS L9L562_TUPCH/2-276       AC L9L562.1
#=GS K7FG74_PELSI/17-306      AC K7FG74.1
#=GS U6DGM9_NEOVI/1-158       AC U6DGM9.1
#=GS Q3TRM5_MOUSE/17-321      AC Q3TRM5.1
#=GS F6TAB6_CHICK/17-89       AC F6TAB6.1
#=GS G1KML5_ANOCA/17-319      AC G1KML5.2
#=GS L5M3T3_MYODS/1-66        AC L5M3T3.1
#=GS F7G8V1_MONDO/17-304      AC F7G8V1.1
#=GS D2GX57_AILME/17-317      AC D2GX57.1
#=GS G3VPY7_SARHA/17-313      AC G3VPY7.1
#=GS SIAL_BOVIN/17-307        AC Q28862.1
#=GS W5NY83_SHEEP/17-303      AC W5NY83.1
#=GS G0SHS4_CHATD/196-318     AC G0SHS4.1
#=GS G1N6F0_MELGA/17-180      AC G1N6F0.2
#=GS L5M3T3_MYODS/43-214      AC L5M3T3.1
#=GS G3ILN2_CRIGR/17-312      AC G3ILN2.1
#=GS G7P5V9_MACFA/4-286       AC G7P5V9.1
#=GS G7MTD4_MACMU/17-315      AC G7MTD4.1
#=GS U3I5J2_ANAPL/17-72       AC U3I5J2.1
#=GS H2PDV2_PONAB/17-314      AC H2PDV2.1
#=GS E2RPB1_CANFA/17-315      AC E2RPB1.2
#=GS H2QPV2_PANTR/17-314      AC H2QPV2.1
#=GS S9XJT7_9CETA/4-287       AC S9XJT7.1
#=GS G1SEM1_RABIT/1-288       AC G1SEM1.2
#=GS H0X499_OTOGA/17-308      AC H0X499.1
#=GS F7I6C9_CALJA/141-291     AC F7I6C9.1
#=GS G3QVT7_GORGO/17-64       AC G3QVT7.1
#=GS H0YVI3_TAEGU/17-81       AC H0YVI3.1
#=GS I3LYK5_SPETR/17-313      AC I3LYK5.1
#=GS H0VK51_CAVPO/17-307      AC H0VK51.1
#=GS F7I6C9_CALJA/17-146      AC F7I6C9.1
#=GS SIAL_PIG/1-300           AC P31936.2
#=GS W4W7I7_ATTCE/9-123       AC W4W7I7.1
#=GS U3I5J6_ANAPL/5-64        AC U3I5J6.1
#=GS G5BSU4_HETGA/17-316      AC G5BSU4.1
#=GS U3I5J2_ANAPL/139-208     AC U3I5J2.1
#=GS I3J5Y7_ORENI/523-650     AC I3J5Y7.1
#=GS H0YVI3_TAEGU/95-287      AC H0YVI3.1
#=GS G3QVT7_GORGO/60-294      AC G3QVT7.1
#=GS L8IEK2_9CETA/17-307      AC L8IEK2.1
#=GS S7N8U5_MYOBR/17-302      AC S7N8U5.1
#=GS V8NVG6_OPHHA/1-246       AC V8NVG6.1
#=GS A0JPM6_RAT/17-316        AC A0JPM6.1
#=GS M3XT14_MUSPF/17-315      AC M3XT14.1
#=GS SIAL_CHICK/77-273        AC P79780.1
#=GS F7EC64_ORNAN/17-303      AC F7EC64.1
#=GS F7I699_CALJA/17-314      AC F7I699.1
#=GS F6TAB6_CHICK/77-273      AC F6TAB6.1
#=GS R0K986_ANAPL/38-161      AC R0K986.1
#=GS W5NY80_SHEEP/9-278       AC W5NY80.1
#=GS G3TER7_LOXAF/17-319      AC G3TER7.1
#=GS G3SAN1_GORGO/17-301      AC G3SAN1.1
#=GS U3JR86_FICAL/17-309      AC U3JR86.1
#=GS L9L5F1_TUPCH/101-374     AC L9L5F1.1
#=GS E7D7Z0_CERNI/17-308      AC E7D7Z0.1
#=GS Q3HLN4_RAT/17-316        AC Q3HLN4.1
#=GS L5KQL8_PTEAL/1-294       AC L5KQL8.1
#=GS G1PF90_MYOLU/17-305      AC G1PF90.1
#=GS SIAL_HUMAN/17-314        AC P21815.4
#=GS B3SXQ5_PALPA/17-334      AC B3SXQ5.1
#=GS G1N6F0_MELGA/139-259     AC G1N6F0.2
#=GS G1REL7_NOMLE/17-314      AC G1REL7.1
#=GS F6YPI2_HORSE/17-308      AC F6YPI2.1
#=GS P70113_MESAU/17-313      AC P70113.1
#=GS A0A024RDE4_HUMAN/17-314  AC A0A024RDE4.1
#=GS SIAL_RAT/17-317          AC P13839.1
#=GS SIAL_CHICK/17-89         AC P79780.1
#=GS M3WAT3_FELCA/17-317      AC M3WAT3.1
#=GS R0K986_ANAPL/136-200     AC R0K986.1
#=GS H3ALZ7_LATCH/19-308      AC H3ALZ7.1
#=GS K7GP14_PIG/17-316        AC K7GP14.1
#=GS SIAL_MOUSE/17-321        AC Q61711.2
M7AV71_CHEMY/343-611                .................nkalygklmiwf----------------------..---..--------.-----------P.DNSSDSEEE.GDG.DSSEEEEEEE.GQ....EQSNEG.N...NG...ENEGEETTTET..PTGKKAV...GKKglgngitkipkKEQDSQS.PE.....NAETG...---.----Esskkgg.........gckapgK...GGKS-EGS...EGEEDSDENEEEEN.......EEEEEETEKVDENGTGGNGT..S.....TNGTD.....TENGNGGNG.-EA..EE......EEEEENETEA-..---------.--TTIVITTPTDPGRG...DTTPTE.D.E.-----....-GVYDTTTPGDL.WGY..........EngETTTPVYENGYESq..tdYNdgRENGYPRGDSYRTY....EDEY.GYYKGHGYDVY-GHDYY............................
I3J5Y8_ORENI/494-621                ......................pvgllvl----------------------..---..--------.------------.---------.---.----------.--....------.-...--...-----------..-------...---...........-------.--.....-----...---.FCWPK.....................K..sDDNYVYKK...VDPPKADVEEEEEE.......EEEEEEEAAVDEEDKGAEAT..EaapaaANATE.....EAEEDAEAG.GDN..VEg....dDEEEEEEEEEE..EEEDSS---.----------------...------.-.-.-----....------------.---..........-..-------------.....--..--------------....----.-----------------ikpdaslsvpqmkdegdvaeeshkqavr
F6TZH2_MACMU/17-315                 .............................FSMKNLHRRVKIEDSEENGVFK..YRP..RYYLYKHA.YFYPPLKRFPVQ.GSSDSSEEN.GD-.DSSEEEEEEE.ET....SNEGEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDAT.PG.....TWYTG...LAA.IQLPK.....................K...AGDVTNKA...TKKEESDEEEEEEEe.....eNENEESEAEVDENEQGINGT..S.....TNSTE.....AENGNGSSG.GDN.gEE......EGEEESVTGAS.aEGTTATGGQ.GKGSSKTTTSPNGGFE...PTTPPP.-.V.YRTTS....LPFGKTTTVEYE.GEY..........E..YTGANEYDNGYEV.....YE..SENGEPRGDNYRAY....EDEY.SYFKGQGYDSYDGQNYY............................
L9L562_TUPCH/2-276                  ...........................vh-------------------VFK..YRP..RYYLYKHA.YFYPPLRRFPVQ.-SSDSSEEN.GDG.DSSEEEEEGE.EA....SNEEEN.N...ED...SNGNEDEDSEA..ENSTLST...TTL...........GYGEEIT.PG.....TGDTG...LAA.IQLPK.....................E...AGDKRNKA...TKQKESDEEEEEEEe.....eNENEENEAEVDENEQGINGT..S.....TNSTE.....VDNGNGSSG.GDN.gEE......EGEEESVTGAV.aEGTTVTRGQ.DNGGSKTTTSSNGGLV...PTTPPQ.-.I.YGTTS....VS---------Y.EEY..........E..HTGTNHYDNEYEV.....YE..NENGEPRGDNYRAY....EDEY.SYYKGQGYGGYGDQDYY............................
K7FG74_PELSI/17-306                 .............................FSAKSFRRRAKSDDSEENAVFK..NRH..RYYFNRYA.YVYPPQRRIQ--.-NSDSSEEDgGDG.DSSEEEEEEE.EG....-QEQSN.K...GN...--NGENEGEET..TTETLTG...TMAvg......kglGKGETKIpKE.....QDSKGpknAGE.RENSK.....................K...GGKGGKSE...GSEDEEDSDENNEAe.....nEEEEAENEKVDENGNGGNGT..S.....TNSTD.....GENGNGGNG.DAE..EE......EKEENEVT---..---------.---TIVLTTTADQGLD...VTTPAE.D.V.-G---....--VYDTTTPADL.LDY..........EngETTTTGYENGYESp..tdYNdgRENGYPRGDNYRTY....EDEY.GYYKGHGYDVY-GHDYY............................
U6DGM9_NEOVI/1-158                  .............................----------------------..---..--------.------------.---------.---.----------.--....------.-...--...-----------..-------...---...........-------.--.....-----...---.-----.....................-...--------...------------EE.......EEDEENEAEVDENGQGINGT..S.....SNSTE.....AENGNGSSD.GDN..GE......EGEKESVTEAQ.aEGTTVARKQ.DNGGSKTTTSPDGGFE...PTTPPP.E.L.YGTTT....RQSGEATPTGYE.EEY..........E..QTGTNEYDNGYEV.....YE..NENGEPRGDNYRAY....EDEY.SYYKGRSYDGYDGQDYY............................
Q3TRM5_MOUSE/17-321                 .............................FSMKNFHRRIKAEDSEENGVFK..YRP..RYFLYKHA.YFYPPLKRFPVQ.GGSDSSEEN.GDG.DSSEEEGEEE.ET....SNEEEN.N...ED...SEGNEDQEAEA..ENSTLSTlsgVTA...........SYGAETT.PQ.....AQTFE...LAA.LQLPK.....................K...AGDTESRA...PKVKESDEEEEEEEe.....eEENENEEAEVDENELAVNGT..S.....TNSTE.....VDGGNGSSG.GDN..GEe....aEAEEASVTEAG.aEGTTGGREL.TSVGTQTAVLLNG-FQ...QTTPPP.E.A.YGTTS....PPIRKSSTVEYG.GEY..........E..QTGN-EYNNEYEV.....YD..NENGEPRGDTYRAY....EDEY.SYYKGHGYEGYEGQNYY............................
F6TAB6_CHICK/17-89                  .............................FSVRSWLRRARAGDSEENAVLK..SRH..RYYLYRYA.--YPPLHRYK--.-GSDSSEEE.GDG.--SEEEEEGG.A-....------.-...--...-----------..-------...---...........-------.--.....-----...---.-----.....................-...--------...--------------.......--------------------..-.....-----.....---------.---..--......-----------..---------.----------------...------.-.-.-----....------------.---..........-..-------------.....--..--------------....----.-----------------pshagtqaageg................
G1KML5_ANOCA/17-319                 .............................FSVKSFRRRFKADDSEENAVFK..NRF..WPFFYRQP.YLYPPMKR--QQ.FNSDSSEEG.YGG.NSSEEEEEEE.AG....----PS.N...EE...-NEGEQEKEEA..---TKAP...SEP...........ATGDKK-.--.....----G...VSD.SKPPKqvpvkkeplgkpgkeggakkaE...KDKAPEKG...GKEEEEDSDENEEEe....neEEENEEQEKVDENGNGVNGT..S.....TNSTA.....EENGNGGKG.---..-E......EEEEEEENEA-..---------.------TTIVPTTLFTtvvPTTEYQ.D.Q.YDTTT...eEQWHAETTPEDQ.WQYdtttedpwvhD..TTTTTGYENGYETqt.dyYG..SENGYPRGDTFRAY....EDEY.SYYKGHGYDVY-GQDYY............................
L5M3T3_MYODS/1-66                   .............................--MKNFHRRAKLEDSEENAVFK..YRP..RYYLYKHA.YFYPPLKRFAVQ.-AGDVGKKA.TKK.EESEEEEEEE.E-....------.-...--...-----------..-------...---...........-------.--.....-----...---.-----.....................-...--------...--------------.......--------------------..-.....-----.....---------.---..--......-----------..---------.----------------...------.-.-.-----....------------.---..........-..-------------.....--..--------------....----.-----------------e...........................
F7G8V1_MONDO/17-304                 .............................FSAKHLYRRAKLEDSEENGVFN..HRH..RYYLNKYS.YFYPPLKRIPVQ.HNGDSSEE-.GDG.DSSEEEEEEE.ET....SNEEES.E...--...TNGSEDEEEEG.gESTTLSA...TTS...........GYEEENT.TA.....SGDVG...LAA.IQIPK.....................K...GEDSKNNT...KKEE-SDEEEEEEEe.....eEENKESEAEVDKNKEVVNGT..D.....H----.....-GDGNGTSG.---..KE......DGEEEEEVE--..NGTESSVDK.DNNSTELATSPNSRYE...STTPLE.G.T.YEVTS....PPYEESTSNLYD.SGY..........E..EPVTNEYDNGYEI.....YE..NENGEPRGDNYRAY....EDEY.SYYKGHPYNGYEGQDYY............................
D2GX57_AILME/17-317                 .............................FSMKNLHRRAKLEDSEENGVFK..YRP..RYSLYKHA.YFYPPLKRFPVQ.SSSDSSEED.GNG.DSSEEEEEEE.ET....SNEEEN.N...EEnanSDENEDEESEA..ENTTLTA...-TP...........GYGEETT.PG.....TGYIG...LAA.IQLPK.....................K...SGDIGHKA...TKEEESDEEEEEDE.......-ENEENEAEVDENGQGINGT..S.....SNSTE.....AENGNGSSD.GDN..GE......EGEEESVTEAH.tEGTTVVGKQ.DNGGSKTTVSPDGGFE...RTTPPP.E.L.YGTTT....RPSGEATPTGYE.GEY..........E..QTGTNEYDNGYEV.....YE..NENGEPRGDNYRAY....EDEY.SYYKGRSYDGYDGQDYY............................
G3VPY7_SARHA/17-313                 .............................FSVKNLYRRAKLGDSEENGVLN..HRH..RYYIYKYS.YLYPPLKRIPVQ.RNGDSSEE-.GDG.ESSEEEEEEE.DTnrfsKNRLFN.K...EN...SNEEEETESNGseESTTLSA...TTL...........GYGEENT.TA.....SGDIG...LAA.IQNPK.....................K...PEEKNNQV...TKKEESDEEEEEEE.......-ENEESEAEVDENKEGGNST..N.....HENAE.....GDHGNGNGG.---..KE......EGEEEEEVE--..NGTEATENE.ASNSTEVTTSLNG-YE...FTTLLK.G.D.FEVTS....PPYEESTSNLYD.SGY..........E..EPVTNEYDNGYEV.....YE..NENREPRGDNYRAY....EDEY.SYYKGHAYNGYGGQDYY............................
SIAL_BOVIN/17-307                   .............................LSMKNLNRRAKLEDSEENGVFK..YRP..QYYVYKHG.YFYPALKRFAVQ.SSSDSSEEN.GNG.DSSEEEEEEE.ET....SNEEGN.NggnED...SDENEDEESEA..ENTTLST...TTL...........GYGE-IT.PG.....TGDIG...LAA.IWLPR.....................K...AGATGKKA...TKEDESDEEEEEEE.......--EEENEAEVDDNEQGINGT..S.....SNSTE.....VDNGHGSSG.GDN.gEE......DGEEESVTEAN.tEGITVAG--.-----ETTTSPNGGFK...PTTPHQ.E.V.YGTTP....PPFGKITTP---.GEY..........E..QTGTNEYDNGYEI.....YE..SENGDPRGDNYRAY....EDEY.SYYKGRGYDSYDGQDYY............................
W5NY83_SHEEP/17-303                 .............................LSMKNLHRRAKLEDSEENGVFK..YRP..RYYLYKHA.YFYPALKRFAVQ.SSSDSSEEN.GNG.DSSEEEEEEE.ET....SNEEGN.NggnED...SDENEDEESEA..ENSTLST...TTL...........GYGEEIT.PG.....TGHIG...LAA.IRLPK.....................K...AGATGKKA...TKEDESDEEEEEEE.......--EEENEAEVDDHEQGINGT..S.....SNSTE.....ADNGHGTSG.GDN..GE......EDGEEESTE--..-GITVAG--.-----ETTASPNGGFK...STTPPQ.E.V.YGTTP....PPFGETTTP---.GEY..........E..QTGTNEYDNGYEI.....YE..SENGDPRGDSYRAY....EDEY.SYYKGRGYDSYDGQDYY............................
G0SHS4_CHATD/196-318                ..............rarsrravtptpapr----------------------..---..--------.------------.---------.---.----------.--....------.-...--...-----------..-------...---...........------T.AG.....ARAPG..pLAA.FAAAW.....................G...AQRKQKQK...QKQQEEEEEEEEEE......eEEEEEEEKEEEEDRQVFVGV..S.....GNMPAccawhWPPHTGNCG.GDS..DSrgvttpEKEEEGEE---..---------.----------------...------.-.-.-----....------------.---..........-..-------------.....--..--------------....----.-----------------qagvslfv....................
G1N6F0_MELGA/17-180                 .............................FSVRSWLRRARAGDSEENAVLK..SRH..RYYLYRYA.--YPPLHRYKVG.PGSDSSEEE.EDG.--SEEEEDGG.VS....--IGLQ.H...AE...---IQGLASEP..SHSFLDE...CTQ...........AAGEGLT.PG.....DTELG...GDA.ASTHQpcpc............vpqgcK...GGQKGTRG...DSGD-EDSDEEEEE......eEEEEEEEEEEEEA-------..-.....-----.....---------.---..--......-----------..---------.----------------...------.-.-.-----....------------.---..........-..-------------.....--..--------------....----.-----------------eatttaa.....................
L5M3T3_MYODS/43-214                 ...........................qa----------------------..---..--------.------------.---------.---.----------.--....------.-...--...-----------..-------...---...........-------.--.....-----...---.-----.....................-...-GDVGKKA...TKKEESEEEEEEEEee...eeNENEENEAEVDENGQGVNGT..S.....TNSTD.....AENGNGSSG.GDN..GE......EGEEEGEEENA..EGTTVAGEQ.D----------NGGSE...PTTPPQ.E.A.YGTTP....PPQGGTTTTEYE.EEY..........E..QTGTNEYDNGYEV.....YE..NENAEPRGDNYRAY....EDEY.SYYKGRGYDSYDGQNYY............................
G3ILN2_CRIGR/17-312                 .............................FSMKNLHRRVKAEDSEENGVFK..YRP..RYFLYKHA.YFYPPLKRFPVQ.GGSDSSEEN.GDG.DSSDEEGE-E.ET....SNEEEN.N...ED...SEGNEDEEAEA..GNTTLSS...VTA...........SYGAETT.TE.....AGSIG...LAA.LQLPK.....................K...AGDAESKA...AKNKESDEEEEEEE.......-ENENEEAEVEENEQVANGT..S.....ANSTE.....AYGGNSSSG.GDN..G-......EGEEQSVTEAG.vEGTTLDREQ.ISDGPTTAVLPNG-FQ...YTTPPP.E.A.YGTTA....PPFRKPTTAEYW.GEY..........E..QTGNNEDNGEYQI.....YD..NENGEPRGDTYRAY....EDEY.SYYKGRGYEGYDGQDYY............................
G7P5V9_MACFA/4-286                  ...........................af------------------SVFK..YRP..RYYLYKHA.YFYPPLKRFPVQ.GSSDSSEEN.GD-.DSSEEEEEEE.ET....SNEGEN.N...EE...SNEGE--DSEA..ENTTLSA...TTL...........GYGEDAT.PG.....TWYTG...LAA.IQLPK.....................K...AGDVTNKA...TKKEESDEEEEEEEe.....eNENEESEAEVDENEQGINGT..S.....TNSTE.....AENGNGSSG.GDN.gEE......EGEEESVTGAS.aEGTTATGGQ.GKGSSKTTTSPNGGFE...PTTPPP.-.V.YRTTS....LPFGKTTTVEYE.GEY..........E..YTGANEYDNGYEV.....YE..SENGEPRGDNYRAY....EDEY.SYFKGQGYDSYDGQNYY............................
G7MTD4_MACMU/17-315                 .............................FSMKNLHRRVKIEDSEENGVFK..YRP..RYYLYKHA.YFYPPLKRFPVQ.GSSDSSEEN.GD-.DSSEEEEXXX.ET....SNEGEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDAT.PG.....TWYTG...LAA.IQLPK.....................K...AGDVTNKA...TKKEESDEEEEEEEe.....eNENEESEAEVDENEQGINGT..S.....TNSTE.....AENGNGSSG.GDN.gEE......EGEEESVTGAS.aEGTTATGGQ.GKGSSKTTTSPNGGFE...PTTPPP.-.V.YRTTS....LPFGKTTTVEYE.GEY..........E..YTGANEYDNGYEV.....YE..SENGEPRGDNYRAY....EDEY.SYFKGQGYDSYDGQNYY............................
U3I5J2_ANAPL/17-72                  .............................FSVKSWLRRVGGDNSEENAVFK..NRR..RYYLYRYA.YL--PQQRYQ--.-GSDS----.---.----------.--....------.-...--...-----------..-------...---...........-------.--.....-----...---.-----.....................-...--------...--------------.......--------------------..-.....-----.....---------.---..--......-----------..---------.----------------...------.-.-.-----....------------.---..........-..-------------.....--..--------------....----.-----------------llaiggeekkh.................
H2PDV2_PONAB/17-314                 .............................FSMKNLHRRVKIEDSEENGVFK..YRP..RYYLYKHA.YFYPHLKRFPVQ.GSSDSSEEN.GD-.DSSEEEEEEE.ET....SNEGEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDAT.LA.....TGYPG...LAA.IQLPK.....................K...AGDITSKA...TKEEESDEEEEEEEe.....eNENEESEAEVDENEQGINGT..S.....TNSTE.....AENGNGSSG.GDN..GE......EGEEESVTGAN.aEGTTATGGQ.GKGSSKTTTSPNGGFE...PTTPPQ.-.V.YRTTS....PPFGKTTTVEYE.GEY..........E..YTGANEYDNGYEI.....YE..SENGEPRGDNYRAY....EDEY.SYFKGQGYDGYDGQNYY............................
E2RPB1_CANFA/17-315                 .............................FSMKNLHRRAKLEDSEENGVFK..YRP..RYYLYKHS.YFYPPLKRFPVQ.SSSDSSEED.GDG.DSSEEEEEEE.ET....SNEEEN.N...EEnanSDENE-DESDA..ENSTLSA...-TP...........GYGEEIT.PG.....TGYIG...LAA.IQLPK.....................K...AGDIRHKA...TKEEESDEEEEEDE.......-ENEENEAEVDENGQGINST..S.....SNSTE.....AENGNGSSA.GDN..G-......EGEEESVTEAH.sEGTTEAGKQ.NNGGSKTTLSPDGGFE...PTTPPP.E.L.YGTTT....RPSGEATPNGYE.EEY..........E..QTGTNEYDNGYEV.....YE..SENGEPRGDNYRAY....EDEY.SYYKGHSYDSYDGQDYY............................
H2QPV2_PANTR/17-314                 .............................FSMKNLHRRVKIEDSEENGVFK..YRP..RYYLYKHA.YFYPHLKRFPVQ.GSSDSSEEN.GD-.DSSEEEEEEE.ET....SNEGEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDTT.PG.....TGYTR...LAA.IHLPK.....................K...AGDITNKA...TKEKESDEEEEEEEe.....eNENEESEAEVDENEQGINGT..S.....TNSTE.....AENGNGSSG.GDN..GE......EGEEESVTGAN.aEGTTETGGQ.GKGSSKTTTSPNGGFE...PTTPPQ.-.V.YRTTS....PPFGKTTTVEYE.GEY..........E..YTGANEYDNGYEI.....YE..SENGEPRGDNYRAY....EDEY.SYFKGQGYDGYDGQNYY............................
S9XJT7_9CETA/4-287                  ...........................af------------------SVFK..YRP..RYYLYKHA.YFYPPLKRFPVQ.SSSDSSEEN.ADG.DSSEEEEEEE.TS....-NEEEN.N...EEnedSDANEDEDSEA..ENATLST...TTL...........GYGEEIT.PG.....TGNIG...LAG.IQLPK.....................K...AGNIGKKA...TKEEESDEEEEEEE......eNENEENEAEVDDNEQVTNGT..S.....TNSTE.....VDSGNGSSG.GDR..--......-GEEEGVTDAS.aKGTTVAGGQ.GNGGSKVTTSPNGRFV...PTPPPG.E.V.HGTTP....PPAGKTTTPGY-.EEY..........E..QTGTSEYDTGYEI.....YE..NENGDPRGDNFRAY....EDEY.SYYKGRGYDSYDGQDY-sy..........................
G1SEM1_RABIT/1-288                  .............................--MKNLHRRVKLQDSEENGVFK..FRP..QYYLYKHA.YFYPPLKRFPVP.-SSDSSEEN.GEG.DSSDEEEEGE.ET....SNEEEN.N...ED...SNGNEDEESEA..ENSTLSF...TTP...........DYGE-IT.RG.....TGYIG...LAG.IKLPK.....................K...AGAIENKA...TEEEESDEEEEEEE......eNENEENEAEVDENEQSINGT..S.....SNSTE.....AEN------.---..GE......AGEGESVTATD.aAGTATRGEW.ISRAAETTTAPSGGFE...PTTPPP.E.A.YGTTS....PPFGKTTAAEYG.GEY..........E..QTGNHGYDDGYEI.....YE..NENGDPRGDNYRAY....EDEY.SYYKGRGYEGYEGQDYY............................
H0X499_OTOGA/17-308                 .............................FSMKNLHRRVKPEDSEENGVFK..YRP..RYYLYKHA.YFYPALKRFPVQ.SSSDSSEEN.EDG.DSSEEEEEEE.ET....SNEEEK.D...EN...SNGGRYLTREF..KALEKSA...TM-...........GEGVLQV.QG.....HGRMG..sELS.FCFSF.....................Q...AGDMRKQA...TKKEESDEEEEEEEe....eeNENEENEAEVDENDQGVNGT..S.....TNSTE.....TENGNGSSG.GDA..GE......GGEGDSVTG--..--------E.TAGTRGQTTSPNGGFQ...PTTPPP.E.V.YGTPS....PPSGKTTTFEYE.EEY..........E..QTGTNEYDNGYEV.....YD..SENGEPRGDTYRAY....EDEY.SYYKGQSYDGYEGYYY-h...........................
F7I6C9_CALJA/141-291                ..........................tnk----------------------..---..--------.------------.---------.---.----------.--....------.-...--...-----------..-------...---...........-------.--.....-----...---.-----.....................-...--------...--------------.......--------AMDENEQGINGT..S.....TNSTE.....AENGNGSSG.GDN.gEE......EGEVESVTGAS.aEGTTATRGQ.GKSTSKTTTSPNGDFE...PTTPPQ.-.P.YRTTS....PPFGKTTTVEYE.GEY..........E..HTGTSEYDNGYEV.....YE..SENGEPRGDSYRAY....EDEY.SYFKGHGYDGYGGQDYY............................
G3QVT7_GORGO/17-64                  .............................FSMKNLHRRVKIEDSEENGVFK..YRP..RYYLYKHA.YFYPHLKRFPVQ.E--------.---.----------.--....------.-...--...-----------..-------...---...........-------.--.....-----...---.-----.....................-...--------...--------------.......--------------------..-.....-----.....---------.---..--......-----------..---------.----------------...------.-.-.-----....------------.---..........-..-------------.....--..--------------....----.-----------------et..........................
H0YVI3_TAEGU/17-81                  .............................FSVKNWLLRPRLDDSEENAVFK..RQH..RHYLYKYI.YVYSPQRRYQ--.-GSDSSEEE.GDG.--SEEEGE--.--....------.-...--...-----------..-------...---...........-------.--.....-----...---.-----.....................-...--------...--------------.......--------------------..-.....-----.....---------.---..--......-----------..---------.----------------...------.-.-.-----....------------.---..........-..-------------.....--..--------------....----.-----------------gglpr.......................
I3LYK5_SPETR/17-313                 .............................LSMKNLHRRIKLEDSEENGVFK..FRP..RYYLYKHA.YFYPPLKRFPVQ.GSSDSSEEN.GDG.DSSDEEEEEE.ET....SNEEEN.N...ED...SNGNEDEESEA..ENTTLSA...TTP...........GYGEEVT.PG.....TGNMG...LAA.IQLPK.....................K...VGDLGNKA...TKKKESDEEEEEEE.......-ENEENEAEVDENEQGINGT..S.....TNSTE.....VENGNGSSG.GDN.rEE......EGGQESVTRAN.vRGTT---QQ.NNGGYKTTTPQNGGFQ...PTTPPP.E.V.YGTTS....PPFGRTTTVEYE.GEY..........E..QMGTNEYGHDYEV.....YD..NENGEPRGDTYRAY....EDEY.SYYKGQGYGGYDSQNYY............................
H0VK51_CAVPO/17-307                 .............................FSMKNLHRRVKLEDSEENGVFK..YRP..RYYLYKHG.YFYPPLKRFAFP.SSSDSSEEN.GNG.DNSEEEEEEE.ET....SNEEEN.N...ED...SNGNEGEESEA..ENTTLST...ATP...........GYGEEIT.AG.....TEYIG...LAA.IRLPK.....................KlygTKFIRHPC...IKAQDRGAHAEAPE.......CSPAIGEAEVDGNEQVVNGT..S.....TNSTE.....LETSTGSSG.ADN..GE......EGEAEGTT---..AGATLTVGQ.TTGSSHTTPSPDAGFE...PTNQTP.E.A.-----....----KTTTAEYG.GEY..........E..QTGGNEYDPGYDV.....YD.aAENGGPRGDNYRAY....EDEY.SYYKGRGYEGYEGQDYY............................
F7I6C9_CALJA/17-146                 .............................FSMKNLHRRVKIEDSEENGVFK..YRP..RYYLYKHA.YFYPPLKRFPVQqGNSDSSEEN.GD-.DSSEEEEEEE.GA....SNEEEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDAT.PG.....TGYTG...LAA.IQLPK.....................K...AGYITNKA...M-------------.......--------------------..-.....-----.....---------.---..--......-----------..---------.----------------...------.-.-.-----....------------.---..........-..-------------.....--..--------------....----.-----------------d...........................
SIAL_PIG/1-300                      .............................FSMKNFHRRAKLEDPEENGVFK..YRP..RYYLYKHA.YFYPPLKRFPVQ.SSSDSSEEN.GNG.DSSEEEEEEE.EN....SNEEEN.N...EEnedSDGNEDEDSEA..ENITLST...TTL...........GYGGDVT.PG.....TASIG...LAA.LQLPK.....................K...AGDIGKKS...AKEEESDEDEEEEE.......-ENEENEAEVDDNEQGTNGT..S.....TNSTE.....VDSGNGHSG.GDN..GE......EGDQESVTEA-..QGTTVAGEQ.DNGGAKTTTSPNGGLE...PTPPPQ.D.I.SGTTL....PPSGKTTTPEYE.GEY..........E..QTGAHEYDNGYEI.....YE..SENGEPRGDSYRAY....EDEY.SYYKGRSYNSYGGHDYY............................
W4W7I7_ATTCE/9-123                  ..........................scq------------------AVFR..QRSnrRKLVVDRL.LFYPSNSEIDVR.TVTFFSFDD.EDG.TDDDDDDDDD.DD....DDDDDD.D...DD...DDNDDDDDDDD..DATTTTT...TTT...........TT-----.--.....-----...---.-----.....................-...--------...--------------.......--------------------..-.....-----.....---------.---..--......-----------..---------.----------------...------.-.-.-----....------------.---..........-..-------------.....--..--------------....----.-----------------marrvgharffarrstsfdrarnymtl.
U3I5J6_ANAPL/5-64                   ..........................war----------------------..---..--------.------------.---------.---.----------.--....------.-...--...-----------..-------...---...........-------.--.....-----...---.-----.....................-...--------...--------------.......--------------------..-.....-----.....---------.---..--......-----------..---------.----------------...------.-.-.-----....----------RQ.WQY..........E..VQTQFCGDEGPTEg...sYG..DHEGYARGDSYRAY....EDEY.GYYKGHGYDVY-GQDYY............................
G5BSU4_HETGA/17-316                 .............................LSMKNLHRRFKLEDSEENGVFK..YRP..RYYLYKHG.YFYPPLKQFAVQ.GNSDSSEEN.GNG.DSSEEEEEED.ET....SNEEEN.N...ED...SNGNEDEDSEA..ENTTLST...ITP...........GYGEETT.PG.....TDYIG...LAA.IQLPK.....................K...AGDIGNKA...TKKEESDEEEEEEE.......NENENNEAEVDGNEQAVNGT..S.....TNSTE.....VENGNGSSG.ADN..GE......EGDKESVTEAN.tPGTTMSAGQ.STGSSKTTPSPNGVFE...PTTPAP.E.V.YGSTP....PPYGKTTTAEYG.AEY..........E..QTGANEYDPGYEV.....YD..NENGGPRGDNYRAY....EDEY.SYYKGRGYDGYDGQDYY............................
U3I5J2_ANAPL/139-208                ........................ngtaa----------------------..---..--------.------------.---------.---.----------.--....------.-...--...-----------..-------...---...........-------.--.....-----...---.-----.....................-...--------...--------------.......--------------------..-.....-----.....---------.---..--......-----------..---------.----------------...------.-.-.-----....EP--EATTVAAT.TGL..........D..EATTAXGDEGPTEg...sYG..DHEGYARGDSYRAY....EDEY.GYYKGHGYDVY-GQDYY............................
I3J5Y7_ORENI/523-650                ......................pvgllvl----------------------..---..--------.------------.---------.---.----------.--....------.-...--...-----------..-------...---...........-------.--.....-----...---.FCWPK.....................K..sDDNYVYKK...VDPPKADVEEEEEE.......EEEEEEEAAVDEEDKGAEAT..E.....AAPAA....eEAEEDAEAG.GDN..VE.....gDDEEEEEEEEE..EEEEEEGEE.ESKAPGRTLEDE----...------.-.-.-----....------------.---..........-..-------------.....--..--------------....----.-----------------mkdegdvaeeshkqavrk..........
H0YVI3_TAEGU/95-287                 .....adcwgvghpagvspedcqgaltgd----------------------..---..--------.------------.---------.---.----------.--....------.-...--...-----------..-------...---...........-------.--.....-----...---.-----.....................-...------RT...ANKEEDSENEDSDE.......NEEEEEDEEVDENENGVNGT..S.....TNTTEg...iGPHGNGTVV.AEE..AT......EEEEEEEEEE-..---EEEEEA.EATTIASTTNEEGLTQ...ATTMDD.GgP.TDATT....----DATTAGEL.WEY..........D..VTARDH-SRGEEGtteggYE..EQDEYARGDSYRAY....EDEY.GYYKGHGYDVY-GQDYY............................
G3QVT7_GORGO/60-294                 ............................v----------------------..---..--------.------------.---------.---.--------QE.ET....SNEGEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDAT.PG.....TGYAG...LAA.IQLPK.....................K...AGDITNKA...TKEKESDEEEEEEEe.....eNENEESEAEVDENEQGINGT..S.....TNSTE.....AENGNGSSG.GDN..GE......EGEEESVTGAN.aEGTTETGGQ.GKGTSKTTTSPNGGFE...PTTPPQ.-.V.YRTTS....PPFGKITTVEYE.GEY..........E..YTGANEYDNGYEI.....YE..SENGEPRGDNYRAY....EDEY.SYFKGQGYDGYDGQNYY............................
L8IEK2_9CETA/17-307                 .............................LSMKNLNRRAKLEDSEENGVFK..YRP..QYYVYKHG.YFYPALKRFAVQ.SSSDSSEEN.GNG.DSSEEEEEEE.ET....SNEEGN.NggnED...SDENEDEESEA..ENTTLST...TTL...........GYGE-IT.PG.....TGDIG...LAA.IWLPR.....................K...AGATGKKA...TKEDESDEEEEEEE.......--EEENEAEVDDNEQGINGT..S.....SNSTE.....VDNGHGSSG.GDN.gEE......DGKEESVTEAN.tEGITVAG--.-----ETTTSPNGGFK...PTIPHQ.E.V.YGTTP....PPFGKTTTP---.GEY..........E..QTGTNEYDNGYEI.....YE..SENGDPRGDNYRAY....EDEY.SYYKGRGYDSYDGQDYY............................
S7N8U5_MYOBR/17-302                 .............................FSMKNFHRRAKLEDSEENGVFK..YRP..RYYLYKHA.YFYPPLKRFPVQ.-NSDSSEEN.GDG.DSSEEEEGEE.EN....SNEEAN.N...EE...--SNEDEESEA..ENSTLSA...TTP...........GYGEETT.PG.....TGNVG...LAA.IQLPK.....................K...AGDVGKKA...TKKEESEEEEEEEE......eNENEENEAEVDENGQGINGT..S.....TNSTD.....VENGNGSSG.GDN..GE......EEEEGEEENA-..EGTTVAGEQ.D----------NGGFE...PTTPPQ.E.V.YGTTP....PPQGGTTTTEYE.GEY..........E..QTGTNEYDNGYEV.....YE..NENAEPRGDNYRAY....EDEY.SYYKGRGYDSYDGQNYY............................
V8NVG6_OPHHA/1-246                  ...........................mp----------------------..---..--------.-----QNCLSFQ.FNSDSSEEG.FGG.NSSEEEEEEE.GG....-QSNEE.N...EG...GKGS-------..EETTVAP...TTP...........AAGDTNT.DGnaeppTEVPG...VKDpLQKPGkeg...............gdkK...VDNAPKKG...AKEEDSDENEEEEN.......--EEEEEEKVDENGSGANGT..S.....TNSTL.....EETGNGGEE.---..--......--EEEEENEA-..--TTI----.SLTTLVTTVNPT---E...STTGEQ.W.Q.-DGTS....PADQGQYDTEDP.WVH..........D..ATTTNGYEVQTDY.....YG..SENGYPRGDNFRTY....EDEY.SYYKGHGYDVY-GQDYY............................
A0JPM6_RAT/17-316                   .............................FSMKNFHRRIKAEDSEENGVFK..YRP..RYFLYKHA.YFYPPLKRFPVQ.GGSDSSEEN.GDG.DSSEEEGEEE.ET....SNEEEN.N...ED...SEGNEDQEAEA..ENATLSG...VTA...........SYGVETT.AD.....AGKLE...LAA.LQLPK.....................K...AGDAEGKA...PKMKESDEEEEEEE......eEENENEEAEVDENEQVVNGT..S.....TNSTE.....VDGGNGPSG.GDN..GE......EAEEASVTEAG.aEGTTAGARElTSYGTTTAVLLNG-FQ...QTTPPP.E.A.YGTTS....PPARKSSTVEYG.EEY..........E..QIGN-EYNTAYET.....YD..ENNGEPRGDTYRAY....EDEY.SYYKGHGYEGYEGQDYY............................
M3XT14_MUSPF/17-315                 .............................FSMKNLHRRAKLQDSEENGVFK..YRP..RYSLYKHA.YFYPPLKRFLAQ.SSSDSSEED.GNG.DSSEEEEEEE.ET....SNEEEN.N...EEnanSDENED-EDEA..ENTTLST...-TP...........GYGE-TT.PG.....TGYIG...LAA.IQLPK.....................K...AGDKGHKA...TEEEESDEEEEEDE.......-ENEENEAEVDENGQGINGT..S.....SNSTE.....AENGNGSSD.GDN..GE......EGEEQSVTEAQ.tEGTTVARKQ.DNGDSKTTTSPDGGFE...PTTPPP.E.F.YGTTT....QQSGEATPTGYE.EEY..........E..QTGTNEYDNGYEV.....YE..NENGEPRGDNYRAY....EDEY.SYYKGRSYDGYDGQDYY............................
SIAL_CHICK/77-273                   .......apshagtqaagegltlgdvgpg----------------------..---..--------.------------.---------.---.----------.--....------.-...--...-----------..-------...---...........-------.--.....----G...DAA.SAHQD.....................C...KGGQKGTR...GDSGDEDSDEEEEE.......EEEEEEEEEVEEQDVSVNGT..S.....TNTTA....eTPHGNNTVA.AEE..EE......DDDEEEEEEEE..----EEEEA.EATTAAA---------...-TTAQD.E.V.TTLGD....EQRSEVTTAGEQ.WEY..........E..VTVGARGDEGPTEs...sYG..DQEEPARGDSYRAY....EDEY.GYYKGHGYDMY-GQDYY............................
F7EC64_ORNAN/17-303                 .............................FSVKNLHRRAKVEESEENAVFK..HRP..RYYIYKYA.YLYPPQKRILSQ.GSIPSSQER.DDG.EKEGEIDINE.TS....NEENEE.N...EE...----EDENSEG.eESTTVSA...TTP...........LYGEETT.PG.....RGDNG...LGA.IKVPK.....................K...NGDVQNTG...MANKMKHIENLTAEtr..kstNENEESEAEVEENEQGINGT..S.....TNSTE.....DS---GNDG.GEN.gGEa....aEEEEESVTEAN..-------QE.ENGGQETTTFVDSVQG...ATTPSN.G.A.YEVTT....PP---TTSN---.-GY..........E..ETVTNEYDSGYEV.....YE..NENAEPRGDNFRTY....EDEY.SNYKGRGYDGYDGRDYY............................
F7I699_CALJA/17-314                 .............................FSMKNLHRRVKIEDSEENGVFK..YRP..RYYLYKHA.YFYPPLKRFPVQ.GNSDSSEEN.GD-.DSSEEEEEEE.GA....SNEEEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDAT.PG.....TGYTG...LAA.IQLPK.....................K...AGYITNKA...MKKKESDEEEEEEE......eEENEESEAEVDENEQGINGT..S.....TNSTE.....AENGNGSSG.GDN.gEE......EGEVESVTGAS.aEGTTATRGQ.GKSTSKTTTSPNGDFE...PTTPPQ.-.P.YRTTS....PPFGKTTTVEYE.GEY..........E..HTGTSEYDNGYEV.....YE..SENGEPRGDSYRAY....EDEY.SYFKGHGYDGYGGQDYY............................
F6TAB6_CHICK/77-273                 .......apshagtqaagegltlgdvgpg----------------------..---..--------.------------.---------.---.----------.--....------.-...--...-----------..-------...---...........-------.--.....----G...DAA.SAHQD.....................C...KGGQKGTR...GDSGDEDSDEEEEE.......EEEEEEEEEVEEQDVSVNGT..S.....TNTTA....eTPHGNNTVA.AEE..EE......DDDEEEEEEEE..----EEEEA.EATTAAA---------...-TTAQD.E.V.TTLGD....EQRSEVTTAGEQ.WEY..........E..VTVGARGDEGPTEs...sYG..DQEEPARGDSYRAY....EDEY.GYYKGHGYDMY-GQDYY............................
R0K986_ANAPL/38-161                 hpgtqvagegvapgdgglggdaaspqkgc----------------------..---..--------.------------.---------.---.----------.--....------.-...--...-----------..-------...---...........-------.--.....-----...---.-----.....................-...--------...-KGAPKGKGGDEDS.......-GEEEEEEEVEEQESSVNGT..S.....TNTTAg..teGPHGNGTAA.AEE..EE......EEDEEEEEEEEeeEEPEATTVA.ATTGLDEA--------...------.-.-.-----....------------.---..........-..-------------.....--..--------------....----.-----------------ttaxgdegpt..................
W5NY80_SHEEP/9-278                  ............................m------------------QVFK..YRP..RYYLYKHA.YFYPALKRFAVQ.SSSDSSEEN.GNG.DSSEEEEEEE.ET....SNEEGN.NggnED...SDENEDEESEA..ENSTLST...TTL...........GYGEEIT.PG.....TGHIG...LAA.IRLPK.....................K...AGATGKKA...TKEDESDEEEEEEE.......--EEENEAEVDDHEQGINGT..S.....SNSTE.....ADNGHGTSG.GDN..GE......EDGEEESTE--..-GITVAG--.-----ETTASPNGGFK...STTPPQ.E.V.YGTTP....PPFGETTTP---.GEY..........E..QTGTNEYDNGYEI.....YE..SENGDPRGDSYRAY....EDEY.SYYKGRGYDSYDGQDYY............................
G3TER7_LOXAF/17-319                 .............................FSMKNLHRRAKLEDSEENRVFK..FRP..QYYLYKHA.YFYPPQKRFPVL.SNSDSSEEN.GDG.YSSEEEEEEE.ES....SNEGEN.N...EEneeSNENEEEESEA..ENTTLST...ATP...........GYGEETT.PG.....TGSLG...LAA.IQLPK.....................K...AKVIPTLN...VPSLVQSHFREENS......kIEKVSRKAEVDENEQGINGT..S.....TNSTD.....TENGNGSNG.GDH.gEE......EGEEESVTEAN.aEEATVTGEQ.GNGGLETTASPNAGFQ...PTAPPQ.D.I.YGTTT....PPFGEITTTGY-.-EY..........E..QTGTNEYDNGYEV.....YE..NENGEPRGDNYRAY....EDEY.SYYKGRSYDGYDGQDYY............................
G3SAN1_GORGO/17-301                 .............................FSMKNLHRRVKIEDSEENGVFK..YRP..RYYLYKHA.YFYPHLKRFPVQ.GNKDSSQEH.THTtHTSLKRGEVK.ET....SNEGEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDAT.PG.....TGYAG...LAA.IQLPK.....................K...AGDITNKA...TKEKE---------.......----SGEAEVDENEQGINGT..S.....TNSTE.....AENGNGSSG.GDN..GE......EGEEESVTGAN.aEGTTETGGQ.GKGTSKTTTSPNGGFE...PTTPPQ.-.V.YRTTS....PPFGKITTVEYE.GEY..........E..YTGANEYDNGYEI.....YE..SENGEPRGDNYRAY....EDEY.SYFKGQGYDGYDGQNYY............................
U3JR86_FICAL/17-309                 .............................FSVKSWLRRPKWDNSEENAVFK..SRH..RHYLYRYI.YVYPPQRRYQ--.-GSDSSEEE.GDG.--SEEEEGGE.PF....YAGTKA.A...G-...------HPAGA..APGDCQD...ALG...........GYVSSPQ.QG.....KDCQG..tLKG.I----.....................-...RQRIASKG...EDSENEDSDENEEE.......-EEEEEEEEVDENENGVNGT..S.....TNTTEg...iGPHGNGTVA.AEEgtGEa...eeEEEEEEEEEEE..EEEEEEEET.EATTIPSTTNDEGLTQ...ATTMDDgG.P.TDATT....DATTDATTAGEL.WEY..........D..VTAR-EHSRGEEGttepgYE..EQDEYARGDSYRAY....EDEY.GYYKGHGYDVY-GQDYY............................
L9L5F1_TUPCH/101-374                .....kflalgthygkvylldvqgnitqk----------------------..---..--------.----------FD.VSSDSSEEN.GDG.DSSEEEEEGE.EA....SNEEEN.N...ED...SNGNEDEDSEA..ENSTLST...TTL...........GYGEEIT.PG.....TGDTG...LAA.IQLPK.....................E...AGDKRNKA...TKQKESDEEEEEEEe.....eNENEENEAEVDENEQGINGT..S.....TNSTE.....VDNGNGSSG.GDN.gEE......EGEEESVTGAV.aEGTTVTRGQ.DNGGSKTTTSSNGGLV...PTTPPQ.-.I.YGTTS....VS---------Y.EEY..........E..HTGTNHYDNEYEV.....YE..NENGEPRGDNYRAY....EDEY.SYYKGQGYGGYGDQDYY............................
E7D7Z0_CERNI/17-308                 .............................LSMKNLHQRAKLEDSEENGVFK..YRP..RYYLYKHA.YFYPALKRFAVQ.SSSDSSEEN.GNG.DSSEEEEEEE.ET....SNEEGN.NggnED...SDENEDEESEA..ENATLST...TTL...........GYGEEIT.PG.....TGHIG...LAA.IRLPK.....................K...AGATGKKA...TEEDESDEEEEEEE.......--EEENEAEVDDNEQGINGT..S.....SNSTE.....VDNGHGSSG.GDN.gEE......EGEEESVTEAN.tEGTAV----.---AGETTISPNGGFK...STTPPQ.E.V.YGTTP....PLFGKTTTP---.GEY..........E..QTGTNEYDNGYEI.....YE..SENGDPRGDSYRAY....EDEY.SYYKGRGYDSYDGQDYY............................
Q3HLN4_RAT/17-316                   .............................FSMKNFHRRIKAEDSEENGVFK..YRP..RYFLYKHA.YFYPPLKRFPVQ.GGSDSSEEN.GDG.DSSEEEGEEE.ET....SNEEEN.N...ED...SEGNEDQEAEA..ENATLSG...VTA...........SYGVETT.AD.....AGKLE...LAA.LQLPK.....................K...AGDAEGKA...PKMKESDEEEEEEE......eEENENEEAEVDENEQVVNGT..S.....TNSTE.....VDGGNGPSG.GDN..GE......EAEEASVTEAG.aEGTTAGVRE.LTSYGTTTAVLLNGFQ...QTTPPP.E.A.YGTTS....PPARKSSTVEYG.EEY..........E..QIGN-EYNTAYET.....YD..ENNGEPRGDTYRAY....EDEY.SYYKGHGYEGYEGQDYY............................
L5KQL8_PTEAL/1-294                  .............................--MKNFHRRAKLEDSEENGVFK..YRP..RYYLYKHA.YFYPPLKRFPVQ.-SSDSSEEN.EDG.DSSDEEEEEE.ET....SNEEAN.N...EE...SDENEDEESEA..ENSTLSA...TTP...........GYGEETT.PE.....AGNIG...LAA.IQLPK.....................K...TGDTGKKA...TKKEESDEEEEEEEeeeeeeeNENEENEAEVDENGQGVNGT..S.....TNSTE.....VENGNGSSG.GDN..EE......EREEESVPDAN.aEGNTVAGEQ.----------DNGRLE...PTTPPQ.E.V.YGATT....PTLEKTTTTEYE.GEY..........E..QTGTNEYDNGYEV.....YE..NENGEPRGDNFRAY....EDEY.SYYKGHSYDGYDGQNYY............................
G1PF90_MYOLU/17-305                 .............................FSMKNFHRRAKLEDSEENGVFK..YRP..RYYLYKHA.YFYPPLKRFPVQ.-NSDSSEEN.GDG.DSSEEEEGEE.EN....SNEEAN.N...EE...--SNEDEESEA..ENSTLSA...TTP...........GYGEETT.PG.....TGNVG...LAA.IQLPK.....................K...AGDVGKKA...TKKEESEEEEEEEEe....eeNENEENEAEVDENGQGVNGT..S.....TNSTD.....VENGNGSSG.GDN..GE......EEEEEGEEETA..EGTTVAGEQ.D----------NGGFE...PTTPPQ.E.V.YGTTP....PPQGGTTTTEYE.GEY..........E..QTGTNEYDNGYEV.....YE..NENAEPRGDNYRAY....EDEY.SYYKGRGYDSYDGQNYY............................
SIAL_HUMAN/17-314                   .............................FSMKNLHRRVKIEDSEENGVFK..YRP..RYYLYKHA.YFYPHLKRFPVQ.GSSDSSEEN.GD-.DSSEEEEEEE.ET....SNEGEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDAT.PG.....TGYTG...LAA.IQLPK.....................K...AGDITNKA...TKEKESDEEEEEEEe.....gNENEESEAEVDENEQGINGT..S.....TNSTE.....AENGNGSSG.GDN..GE......EGEEESVTGAN.aEDTTETGRQ.GKGTSKTTTSPNGGFE...PTTPPQ.-.V.YRTTS....PPFGKTTTVEYE.GEY..........E..YTGANEYDNGYEI.....YE..SENGEPRGDNYRAY....EDEY.SYFKGQGYDGYDGQNYY............................
B3SXQ5_PALPA/17-334                 .............................FSIKSFRRRAKSDDSEENAVFK..NRH..RYYFYRYA.YVYPPQRRMQ--.-SSDSSEEE.GDG.DSSDEEEEEGqEQ....SNEGEN.E...GD...-----ETTTEA..PTGKVPV...DKKgf.......skGETKAPK.KG.....QDCKG...PGK.EEMSEa...................lKrggKGKAPEKGgmsKGSENEDSDENEEE......dNEEEENEEKVDENGNGINGT..S.....TNTTE.....AETGNGGNGlGEN..GE......GNGNEGAEEGNeeEEEEEENET.EAMTVITTTGDQGLYD...TTTTED.E.VpYDTATtedeVPYDTTTTVDQGgYGY..........E..ESPTPGYENGYESqtdynYG..SENGYPRGDTYRTY....EDEY.SYYKGHGYDVY-GHDYY............................
G1N6F0_MELGA/139-259                .......................ggqkgt----------------------..---..--------.------------.---------.---.----------.--....------.-...--...-----------..-------...---...........-------.--.....-----...---.-----.....................-...--------...--------------.......--------------------..-.....-----.....----RGDSG.-DE..DS......DEEEEEEEEE-..-EEE--EEE.EEEAEATTT------A...ATTAQD.E.V.TTLGN....EQHSEATTAGEQ.WEY..........E..VTVGARGDEGPTEg...sYG..DQEGPARGDSYRAY....EDEY.GYYKGHGYDIY-GQDYY............................
G1REL7_NOMLE/17-314                 .............................FSMKNLHRRVKIEDSEENGVFK..HRP..RYYLYKHA.YFYPHLKRFPVQ.GSSDSSEEN.GD-.DSSEEEEEEE.ET....SNEGEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDAT.PG.....IGYTG...LAA.IQLPK.....................K...AGDITNKA...TKEKESDEEEEEEEe.....eNENEESEAEVDENEQGINGT..S.....TNSTE.....AENGNGSSG.GDN..GE......EGEEESVTGAN.aEGTTATGGQ.GKGSSKTTTSPNGGFE...PTTPPQ.-.V.YRTIS....PPFGKTTTVQYE.GEY..........E..YTGANEYDDGYEI.....YE..SENGEPRGDNYRAY....EDEY.SYFKGQGYDGYDGQNYY............................
F6YPI2_HORSE/17-308                 .............................LSMKNLHRRAKLEDSEENGVYK..YRP..QYSLYKHA.YFYPPLKRFPVQ.TSSDSSEEN.GDG.DSSEEEEEEE.ET....SNEEGN.N...GEnedSEGNEDEESDA..ENTTLST...ITP...........GYGEEPT.PG.....MGNIG...LAA.IQLPK.....................K...AGDKGNKG...TKEEESDEEEEEEE.......DENEENEAEVDENGQGINGT..S.....SNSTE.....AENGHGSSG.GDN..GE......EEGEEEANA--..EGTAVPAEQ.DNAGSKTTTSPNGGFA...PTTPPQ.E.V.YRTTT....--------TAYE.GEY..........E..QTGTNEYDNGYEV.....YE..NENGEPRGDNYRAY....EDEY.SYYKGRSYDGYDGQDYY............................
P70113_MESAU/17-313                 .............................FSMKNFHRRVKAEDSEDNGVFK..YRP..RYFLYKHA.YFYPSLKRFSVQ.GGSDSSEEN.GDG.DSSEEEGE-E.ET....SNEEEN.N...EE...SEGNEDEEAEA..ENTTLSS...VTT...........SYGAETT.TG.....TGNIG...LAA.LQLPK.....................K...AGNAESKA...AKKKESDEEEEEEE.......-ENENEEAEVEENEQVTNGT..S.....TNSTE.....VYGGNGSSG.GYN..GE......EGEEQSVTEAG.vEGTTVGREQ.ISDGPTTAVLMNG-FQ...YTTPPP.E.A.YGTTS....PPFRKPTTVEYW.GEY..........E..QTGNNEYNGEYQI.....YD..NENGEPRGDNYRAY....EDEY.SYYKGRGYEGYDGQDYY............................
A0A024RDE4_HUMAN/17-314             .............................FSMKNLHRRVKIEDSEENGVFK..YRP..RYYLYKHA.YFYPHLKRFPVQ.GSSDSSEEN.GD-.DSSEEEEEEE.ET....SNEGEN.N...EE...--SNEDEDSEA..ENTTLSA...TTL...........GYGEDAT.PG.....TGYTG...LAA.IQLPK.....................K...AGDITNKA...TKEKESDEEEEEEEe.....gNENEESEAEVDENEQGINGT..S.....TNSTE.....AENGNGSSG.EDN..GE......EGEEESVTGAN.aEGTTETGRQ.GKGTSKTTTSPNGGFE...PTTPPQ.-.V.YRTTS....PPFGKTTTVEYE.GEY..........E..YTGANDYDNGYEI.....YE..SENGEPRGDNYRAY....EDEY.SYFKGQGYDGYDGQNYY............................
SIAL_RAT/17-317                     .............................FSMKNFHRRIKAEDSEENGVFK..YRP..RYFLYKHAtYFYPPLKRFPVQ.GGSDSSEEN.GDG.DSSEEEGEEE.ET....SNEEEN.N...ED...SEGNEDQEAEA..ENATLSG...VTA...........SYGVETT.AD.....AGKLE...LAA.LQLPK.....................K...AGDAEGKA...PKMKESDEEEEEEE......eEENENEEAEVDENEQVVNGT..S.....TNSTE.....VDGGNGPSG.GDN..GE......EAEEASVTEAG.aEGTTAGVRE.LTSYGTTTAVLLNGFQ...QTTPPP.E.A.YGTTS....PPARKSSTVEYG.EEY..........E..QIGN-EYNTAYET.....YD..ENNGEPRGDTYRAY....EDEY.SYYKGHGYEGYEGQDYY............................
SIAL_CHICK/17-89                    .............................FSVRSWLRRARAGDSEENAVLK..SRH..RYYLYRYA.--YPPLHRYK--.-GSDSSEEE.GDG.--SEEEEEGG.A-....------.-...--...-----------..-------...---...........-------.--.....-----...---.-----.....................-...--------...--------------.......--------------------..-.....-----.....---------.---..--......-----------..---------.----------------...------.-.-.-----....------------.---..........-..-------------.....--..--------------....----.-----------------pshagtqaageg................
M3WAT3_FELCA/17-317                 .............................FSTKNLHRRAKLEDSEENGVFK..YRP..RYYLYKNA.YFYPPLKRFPVQ.SSSDSSEEN.GDG.DSSEEEEEEE.EA....SNEEEN.N...EEnanSDENEDEESEA..ENTTLSA...-TP...........GYGEETT.PG.....TGNIG...LAA.IQLPK.....................K...AGDTK-KA...TREEESDEEEEEDE.......-ENEETE-EVDENEQGINSTstS.....TNSTE.....VENGNGSSD.GNT..GE......EGEEESVTEVN.aEGTTMAGRQ.DNGGSTTTTSPNGGFQ...PTTPPP.E.F.YGTTI....RPSREATTTGYE.EEY..........E..QTGTNEYDNGYEV.....YE..NENGEPRGDNYRAY....EDEY.SYYKGRSYDSYDGQDYY............................
R0K986_ANAPL/136-200                ...........................ep----------------------..---..--------.------------.---------.---.----------.--....------.-...--...-----------..-------...---...........-------.--.....-----...---.-----.....................-...--------...--------------.......--------------------..-.....-----.....---------.---..--......-----------..---------.----------------...------.-.-.-----....----EATTVAAT.TGL..........D..EATTAXGDEGPTEg...sYG..DHEGYARGDSYRAY....EDEY.GYYKGHGYDVY-GQDYY............................
H3ALZ7_LATCH/19-308                 .........................ayrr------YRKAKADDSDENGVTKnnHRH..RYYVYKYV.YMNSPQKHAAAQ.KNVDSSEEN.GD-.DSSNELETKK.EG....DSEEDNgN...GNn.nSNGNEEDDNGG..ENGDGGN...GN-...........GYDEDN-.-G.....KNH--...-RQ.VKYKT.....................K...IEVGRKYI...TQNKDRGDDHDDYG.......-DNGNHGRNGDNGNYGHNGN..Y.....GHHGD....nGVNGNGENG.GED.nGD......DSNGENGGEH-..NGD--VSNG.ENGGEHNGYGSNG---...ENAGEH.N.G.YGSNG....ENAGEDNEQENN.ADY..........N..KGSEDNGENGDEE.....YE.dNDNGE-NGDGYRYIngenEEDYdEHYNGYAYH--------gny.........................
K7GP14_PIG/17-316                   .............................FSMKNFHRRAKLEDPEENGVFK..YRP..RYYLYKHA.YFYPPLKRFPVQ.SSSDSSEEN.GNG.DSSEEEEEEE.EN....SNEEEN.N...EEnedSDGNEDEDSEA..ENITLST...TTL...........GYGGDVT.PG.....TASIG...LAA.LQLPK.....................K...AGDIGKKS...AKEEESDEDEEEEE.......-ENEENEAEVDDNEQGTNGT..S.....TNSTE.....VDSGNGHSG.GDN..GE......EGDQESVTEA-..QGTTVAGEQ.DNGGAKTTTSPNGGLE...PTPPPQ.D.I.SGTTL....PPSGKTTTPEYE.GEY..........E..QTGAHEYDNGYEI.....YE..SENGEPRGDSYRAY....EDEY.SYYKGRSYNSYGGHDYY............................
SIAL_MOUSE/17-321                   .............................FSMKNFHRRIKAEDSEENGVFK..YRP..RYFLYKHA.YFYPPLKRFPVQ.GGSDSSEEN.GDG.DSSEEEGEEE.ET....SNEEEN.N...ED...SEGNEDQEAEA..ENSTLSTlsgVTA...........SYGAETT.PQ.....AQTFE...LAA.LQLPK.....................K...AGDAESRA...PKVKESDEEEEEEEe.....eEENENEEAEVDENELAVNGT..S.....TNSTE.....VDGGNGSSG.GDN..GEe....aEAEEASVTEAG.aEGTTGGREL.TSVGTQTAVLLNG-FQ...QTTPPP.E.A.YGTTS....PPIRKSSTVEYG.GEY..........E..QTGN-EYNNEYEV.....YD..NENGEPRGDTYRAY....EDEY.SYYKGHGYEGYEGQNYY............................
#=GC seq_cons                       .............................hShKshhRRhKh-DSEENuVFK..aRs..RYYLYKaA.YFYPsLKRasVQ..sSDSSEEs.GcG.DSSEEEEEcE.Es....sNEttN.N...E-.....tsE-p-uEA..EssTLSs...sT............uYGtphT.su.....ss.hG...LAA.lphPK.....................K...uGshtpKu...s+pcEuDE-EEEEE........EpEEpEAEVDENcQGlNGT..S.....oNSTE.....s-sGNGoSG.GDs..tE......EsEEEsssts...pGss.sttt.ttss.poTssssGhhp...sTTPs....s.YtoTs.....s.tcsTTst.t.tEY..........E..pTGssEYDsGYEl.....Y-..sENG-PRGDsYRAY....EDEY.SYYKG+GYDuYtGQsYY............................
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