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Database: Pfam
Entry: Bacteriocin_IIc
LinkDB: Bacteriocin_IIc
Original site: Bacteriocin_IIc 
#=GF ID   Bacteriocin_IIc
#=GF AC   PF10439.7
#=GF DE   Bacteriocin class II with double-glycine leader peptide
#=GF AU   Coggill P
#=GF SE   Manual
#=GF GA   27.00 27.00;
#=GF TC   27.20 27.00;
#=GF NC   26.90 26.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17074857
#=GF RT   The blp bacteriocins of Streptococcus pneumoniae mediate
#=GF RT   intraspecies competition both in vitro and in vivo. 
#=GF RA   Dawid S, Roche AM, Weiser JN; 
#=GF RL   Infect Immun. 2007;75:443-451.
#=GF RN   [2]
#=GF RM   17298586
#=GF RT   Diversity of enterococcal bacteriocins and their grouping in a
#=GF RT   new classification scheme. 
#=GF RA   Franz CM, van Belkum MJ, Holzapfel WH, Abriouel H, Galvez A; 
#=GF RL   FEMS Microbiol Rev. 2007;31:293-310.
#=GF DR   INTERPRO; IPR019493;
#=GF CC   This is a family of bacteriocidal bacteriocins secreted by
#=GF CC   Streptococcal species in order to kill off closely-related
#=GF CC   competitor Gram-positives. The sequence includes the peptide
#=GF CC   precursor, this being cleaved off proteolytically at the
#=GF CC   double-glycine. The family does not carry the YGNGVXC motif
#=GF CC   characteristic of pediocin-like Bacteriocins, Bacteriocin_II
#=GF CC   Pfam:PF01721. The producer bacteria are protected from the
#=GF CC   effects of their own bacteriocins by production of a specific
#=GF CC   immunity protein which is co-transcribed with the genes encoding
#=GF CC   the bacteriocins, eg family EntA_Immun Pfam:PF08951. The
#=GF CC   bacteriocins are structurally more specific than their
#=GF CC   immunity-protein counterparts. Typically, production of the
#=GF CC   bacteriocin gene is from within an operon carrying up to 6 genes
#=GF CC   including a typical two-component regulatory system (R and H), a
#=GF CC   small peptide pheromone (C), and a dedicated ABC transporter (A
#=GF CC   and -B) as well as an immunity protein [1]. The ABC transporter
#=GF CC   is thought to recognise the N termini of both the pheromone and
#=GF CC   the bacteriocins and to transport these peptides across the
#=GF CC   cytoplasmic membrane, concurrent with cleavage at the conserved
#=GF CC   double-glycine motif. Cleaved extracellular C can then bind to
#=GF CC   the sensor kinase, H, resulting in activation of R and
#=GF CC   up-regulation of the entire gene cluster via binding to
#=GF CC   consensus sequences within each promoter [2]. It seems likely
#=GF CC   that this whole regulon is carried on a transmissible plasmid
#=GF CC   which is passed between closely related Firmicute species since
#=GF CC   many clinical isolates from different Firmicutes can produce at
#=GF CC   least two bacteriocins. and the same bacteriocins can be
#=GF CC   produced by different species.
#=GF SQ   61
#=GS I5BT60_9BACT/1-80    AC I5BT60.1
#=GS Q8DWB6_STRMU/1-76    AC Q8DWB6.1
#=GS D9SPP3_CLOC7/1-70    AC D9SPP3.1
#=GS B9DTX8_STRU0/1-88    AC B9DTX8.1
#=GS Q8DSA3_STRMU/1-62    AC Q8DSA3.1
#=GS T1ZF04_STRIT/6-65    AC T1ZF04.1
#=GS G5JUV8_9STRE/6-84    AC G5JUV8.1
#=GS Q5FI73_LACAC/1-64    AC Q5FI73.1
#=GS D5GZQ7_LACCS/1-62    AC D5GZQ7.1
#=GS B7GL23_ANOFW/1-65    AC B7GL23.1
#=GS L0KCR9_HALHC/1-56    AC L0KCR9.1
#=GS G5JUX6_9STRE/6-70    AC G5JUX6.1
#=GS C0MH63_STRS7/6-84    AC C0MH63.1
#=GS G5JW56_9STRE/4-52    AC G5JW56.1
#=GS Q8DSB5_STRMU/7-81    AC Q8DSB5.1
#=GS T1ZF76_STRIT/6-81    AC T1ZF76.1
#=GS Q03D40_LACC3/1-65    AC Q03D40.1
#=GS T1ZF07_STRIT/6-72    AC T1ZF07.1
#=GS B7GM69_ANOFW/1-58    AC B7GM69.1
#=GS R2S5N8_9ENTE/3-54    AC R2S5N8.1
#=GS G5JUX5_9STRE/5-59    AC G5JUX5.1
#=GS G5JUX8_9STRE/1-66    AC G5JUX8.1
#=GS Q9A138_STRP1/1-58    AC Q9A138.1
#=GS F5IUS8_9PORP/1-57    AC F5IUS8.1
#=GS D9SR35_CLOC7/1-57    AC D9SR35.1
#=GS Q03ZY1_LEUMM/2-53    AC Q03ZY1.1
#=GS F9HJ90_9STRE/1-55    AC F9HJ90.1
#=GS Q8DWB7_STRMU/1-64    AC Q8DWB7.1
#=GS Q8DSA2_STRMU/6-60    AC Q8DSA2.1
#=GS Q035H7_LACC3/1-69    AC Q035H7.1
#=GS U2J410_9STRE/2-66    AC U2J410.1
#=GS C0MH54_STRS7/1-82    AC C0MH54.1
#=GS G5JUW5_9STRE/1-77    AC G5JUW5.1
#=GS Q8DW08_STRMU/1-66    AC Q8DW08.1
#=GS B7GL22_ANOFW/1-86    AC B7GL22.1
#=GS B2JC36_NOSP7/14-67   AC B2JC36.1
#=GS D7N233_9NEIS/1-72    AC D7N233.1
#=GS I0XAR7_9SPIO/62-123  AC I0XAR7.1
#=GS Q03D42_LACC3/1-65    AC Q03D42.1
#=GS R2SSJ5_9ENTE/1-57    AC R2SSJ5.1
#=GS Q8DSB1_STRMU/8-94    AC Q8DSB1.1
#=GS LAFA_LACJO/1-75      AC P24022.2
#=GS D9SR36_CLOC7/1-58    AC D9SR36.1
#=GS Q1WQX8_LACS1/1-65    AC Q1WQX8.1
#=GS L0KBX3_HALHC/1-64    AC L0KBX3.1
#=GS Q5M2W2_STRT2/6-69    AC Q5M2W2.1
#=GS B9JN18_AGRRK/1-51    AC B9JN18.1
#=GS Q9A139_STRP1/2-63    AC Q9A139.1
#=GS D9SSI4_CLOC7/1-70    AC D9SSI4.1
#=GS G5JUY1_9STRE/2-43    AC G5JUY1.1
#=GS Q8DVP7_STRMU/6-73    AC Q8DVP7.1
#=GS G6ERX6_STRTR/6-77    AC G6ERX6.1
#=GS C0MH64_STRS7/1-61    AC C0MH64.1
#=GS Q8DRN0_STRR6/6-65    AC Q8DRN0.1
#=GS LAFX_LACJO/1-57      AC Q48509.1
#=GS G5JXF5_9STRE/6-67    AC G5JXF5.1
#=GS Q8DS95_STRMU/6-72    AC Q8DS95.1
#=GS A5CZV1_PELTS/2-61    AC A5CZV1.1
#=GS Q9PCT5_XYLFA/1-72    AC Q9PCT5.1
#=GS C0MFS4_STRS7/6-73    AC C0MFS4.1
#=GS Q1WQX7_LACS1/2-62    AC Q1WQX7.1
I5BT60_9BACT/1-80               mkggrflkilnrvgvkqnlfim--..........QFEELNNNELAEVNGG............-----LLG.GLLGGVLGGNNSGQN.....................----..---ASGGL.LGGFLGGL-lggnnsggfgs.....
Q8DWB6_STRMU/1-76               ...............mewrintMEln......vnNYKSLTNDELSEVFGG............---DKQAA.DTFLSAVGGAASGFTyca...............sngVWHP..YILAGCAG.VGAVGSVV-f...............
D9SPP3_CLOC7/1-70               ......................MT..........NFETCTMDELVLIDGGdw.......swkSLAQSTVS.GAVGGAIAGSAGGTV.....................TLPV..VGTVGGGV.GGGILGAV-ggaa............
B9DTX8_STRU0/1-88               ...mekllfqkrkvdilmnsni--..........EFDSIDTELLEKVIGG...........kNNWQANVS.GILAAGAAGAAIGAPvcglac.........gyigakTAIT..LWAGVTGA.TGGF-----k...............
Q8DSA3_STRMU/1-62               ......................MEkq......ynNFKILNTDALENIQGGgr.......aprCAALVGAS.IYDGLAVVGDPVGVA.....................----..-MAAGTIA.AGSF-----c...............
T1ZF04_STRIT/6-65               ......................LE..........KFEALNSEMLARVEGG............------GC.NWGDFAKSGIAGGAGng.................lrLGIK..TRTWQGVV.AGAIIGGV-g...............
G5JUV8_9STRE/6-84               ......................LE..........QFDTMDVDMLAAVEGGn.........wgQCIVGTGS.SALAGGLAGAGTGAGigaavsa.......paaegggLGPI..AGAAIGWD.LGAISGAGL................
Q5FI73_LACAC/1-64               ......................ME..........KLMVLNEEKLSYVIGGgnp......kvaHCASQIGR.STAWGAVSGAATGTA.....................----..VGQAVGAL.GGALFGGS-m...............
D5GZQ7_LACCS/1-62               ......................MS..........KVEVLNEEELTTVVGGthskgfhpskgmKCLSGLTT.GFGIGLM--------.....................----..RGSAFGAA.WGL------akasvl..........
B7GL23_ANOFW/1-65               ......................MR..........MFQELNHVELQGIDGGs.........wkSHVVNLVG.VVSGFGTTGAVIGGS.....................FGGP..LGAAAGGF.VGAHYGA--va..............
L0KCR9_HALHC/1-56               ..............mnelstvg--..........NFEELSEDEYLNVDGG............---LVITG.TAVAAGVGCLAGGVT.....................----..----VGYA.IGT------viesv...........
G5JUX6_9STRE/6-70               ......................FE..........QFDVMDNEALSVVEGG............---YNCTG.DFVTGVASGTAGGAL.....................AGGP..VGAFVGAH.VGVIAGG--lkcvggql........
C0MH63_STRS7/6-84               ......................MK..........QFEIIDADKLAHVEGG...........kNNWQTNVW.EGGTAAVGGWTLGTTicaasgagapfmgacgyigakFGVS..LWAGVTGA.TGGF-----................
G5JW56_9STRE/4-52               ...................mti-E..........KFEVMNAQELAAVEGGiv.......itgTAVALGVG.IAAGSFAIGYTIG--.....................----..--------.---------qsl.............
Q8DSB5_STRMU/7-81               ......................LE..........QFDAMDVDMLAAVEGGn.........wgQCIVGTGS.SALAGGLAGAGTGAAvsapa...........aegggLGPI..AGAAIGWD.LGAISGAGL................
T1ZF76_STRIT/6-81               ......................LE..........KYEVLNSEMLASVEGG............YNTSDCLK.DYGKGFLSGTAAGAA.....................-WGS..IAGGIGAL.PGAFVGAHVgiiggglacignmlg.
Q03D40_LACC3/1-65               ......................MS..........KTRKLSELELQQFVGG............SDSNKCLM.GLVGGWAIGGLNGAGs..................lsGFGP..AGVTIGGL.YGTLSGIL-t...............
T1ZF07_STRIT/6-72               ......................LE..........KFEVLNSEMLASVEGGkrp.....ggapVTGMTQAH.YTCLAATWGATFGGM.....................LAPIslIGSV----.---------pgvlaacsg.......
B7GM69_ANOFW/1-58               ......................--..........-MKELKADELVSIDGG............--ISACGKvSVAAFAHTAAFTGLM.....................TFAG..VSGPVGWV.LGTFVGGA-w...............
R2S5N8_9ENTE/3-54               ......................ME..........KTKVLNVKEMKKVIGGn.........dvSCAVGIAV.GAGAGGVIGAIGGLL.....................----..--------.---------tecvqwgy........
G5JUX5_9STRE/5-59               ..................dymd--..........-YKSLTEDELSQIEGG............---KSGIF.-----KAAGYCAGDA.....................LLGV..WGGPAGMA.AGCAVGV--ve..............
G5JUX8_9STRE/1-66               .....................m-Kni......nqKFTELKNIELSSITGG............---DRRLG.NAVISAAMGAVEGAKa..................csLGGP..WVVAACAAgAGAYSG---yw..............
Q9A138_STRP1/1-58               ......................MD..........NFLELQFEELVNISGGkg.......nigSAIGGCLG.GMLIAAAGGPITGGA.....................----..-AAFVCVA.SG-------iaa.............
F5IUS8_9PORP/1-57               .....................m-EkelttlnetsEFKELTKEEMAAINGGya........igDYLKDLYE.SAGAAVAAGAAAGAA.....................----..--------.---------ai..............
D9SR35_CLOC7/1-57               ......................ME..........NFVSLTEVELHEIEGGrw........swKKIAKVAF.AVIKTATTIASGGAV.....................---I..PAVI----.---------kgaitii.........
Q03ZY1_LEUMM/2-53               ..............hkndlinf-S..........NFSQLDEYQLASVDGG............FIPVAVWA.LWAGAGAAGFSGGIA.....................----..--------.---------vgln............
F9HJ90_9STRE/1-55               ..............mkplnkmd-E..........QFYVLSDEEMATVEGG............------GI.LFGIVIVGGIIVGGT.....................----..------FV.LGAIDGA--mgar............
Q8DWB7_STRMU/1-64               .................mdtqaFE..........QFDVMDSQTLSTVEGG............--------.-KVSGGEAVAAIGIC.....................----..--ATASAA.IGGLAGAT-lvtpycvgtwgli...
Q8DSA2_STRMU/6-60               ......................LE..........QFDVMDSQVPSAIEGG............------GC.SWKGADKAGFSGGVG.....................---G..LIGAGGNP.VGGVLGIA-ggl.............
Q035H7_LACC3/1-69               ...................msy--..........NYRQIDDFQLSGVSGG............KKKFDCAA.TFVTGITAGIGSGTI.....................-TGL..AGGPFGII.GGAVVGGNLgavgsai.........
U2J410_9STRE/2-66               ................mktqai-E..........KFDVMDTEALSTVEGG............-----GTG.ACLASAATAIGLGAAavgs.............svlpAAAL..YLGAQAFA.AGA------n...............
C0MH54_STRS7/1-82               ...............mntetin--..........QFDVMNIEALATVEGG............YSGKDCLK.DMGGYMLIGAGSGAL.....................-WGA..PAGGIGVL.PGAFVGAHVgtigggfacmggmign
G5JUW5_9STRE/1-77               .................meikaLD..........QFETMDTDMLAAVEGGfgwgs..iwrgfKCVAGTAG.TIGTGALGGSTTGGL.....................TLPI..IGHVSGGI.IGGISGAGV................
Q8DW08_STRMU/1-66               .................mdtmaFE..........NFDEIDMNHLASIEGG............-------F.DVKGVAASYLAMGTA.....................--AL..GGLACTTP.VGAV-----lylgaevcagaav...
B7GL22_ANOFW/1-86               ..............megvvftm-Elml...ekngSISFLSEEELKEIDGGrgs.....wtnaVIGAGTLS.PIVASAVRGAQQGVRf..................grLGGP..WGVVAGAV.VGAVVGGYL................
B2JC36_NOSP7/14-67              .................ekevl--..........-LSELSDEEMATIQGG............--SNAPAE.VLAVCAVGGAVLGGP.....................----..----AGFL.GGAFVGAIL................
D7N233_9NEIS/1-72               .............mqafyadkt--..........EIRTLSMDELSLVAGGf..........nWDKVQWGK.AVAVGAVTGLSAGVA....................gLTGG..PGVAAAAA.AGGFVGGF-g...............
I0XAR7_9SPIO/62-123             ...............seqtkes-E..........NTEYLSEDALEEVAGGs..........vTSWMHRNK.DWVIAATALATIGAC.....................----..--------.---------ymfnkylekksaa...
Q03D42_LACC3/1-65               ......................MK..........DVSVLNVTELAQVTGGg.........igKCIAGTVG.GGVMGALTGGGLGSK.....................TKNL..YVIGGLGI.LGGVGGAIY................
R2SSJ5_9ENTE/1-57               ......................MQ..........NVKELNIQKMQKITGG............---NSCTN.GTIGGAIAGAPGGPL.....................-SFL..AGAAGGAV.AGGC-----ikfg............
Q8DSB1_STRMU/8-94               ...........dkmdemriymm-Eik.....aldQFETMDTDMLAAVEGGfgwds..iwrgfKCVAGTAG.TIGTGALGGSATGGL.....................TLPI..IGHVSGGI.IGGISGAGV................
LAFA_LACJO/1-75                 ......................MK..........QFNYLSHKDLAVVVGG...........rNNWQTNVG.GAVGSAMIGATVGGTicgpac.........avagahYLPI..LWTAVTAA.TGGFGKI--rk..............
D9SR36_CLOC7/1-58               ......................ME..........NFKTLSEVELHQIDGGkw........kwKKIIKIAA.AVAGTVVTIASGGAA.....................----..---APAVI.GGAI-----avan............
Q1WQX8_LACS1/1-65               ................mknldk--..........RFTIMTEDNLASVNGGkngy....ggsgNRWVHCGA.GIVGGALIGAIGGPW.....................----..-----SAV.AGGISGGF-t...............
L0KBX3_HALHC/1-64               ..............mdnlasvg--..........-MVELNEEELMMVDGG............---FFSVT.DLGWAAAGGAISGAI.....................TYGS..IGGAPGAV.AGAFTGAAL................
Q5M2W2_STRT2/6-69               .....................i-E..........NFNTLDLETLASVEGG............------GC.SWGGFAKQGVATGVGng.................lrLGIK..TRTWQGAV.AGAAGGAIVggvg............
B9JN18_AGRRK/1-51               ......................MS..........NITEINADMLDLVSGG............---ASTVA.STVTIGADGAVSGSY.....................TFGS..--------.---------rsgtfsatl.......
Q9A139_STRP1/2-63               ...................ikf--..........-AEEIQKEELFHIIGG............YSATDCKN.HLIGGITSGAIAGGV.....................GAGM..ATLGVGGV.AGAFAGAHV................
D9SSI4_CLOC7/1-70               ................mnllvn-E..........NFTDLRIDEIEFINGGm.........sdWDWVWCGV.VTAGCTVIGAAIGTA.....................VCPG..IGTIGGAN.AGSVLGGIF................
G5JUY1_9STRE/2-43               ....................ti-E..........KFEVMNAQELAAVEGG............--SKISAG.DLARAGAICTASGAC.....................----..--------.---------yw..............
Q8DVP7_STRMU/6-73               ......................FE..........QFNVMDNEALSTVEGGg.........miRCALGTAG.SAGLGFVGGMGAGTV.....................TLPV..VGTVSGAA.LGGWSGAAVgaa.............
G6ERX6_STRTR/6-77               .....................i-E..........NFNTLDLETLASVEGG...........gCSWGGTGG.ATVQGAIGGAFGGNV.....................VLPV..VGSVPGYL.AGGVLGGA-ggtvaygatc......
C0MH64_STRS7/1-61               ......................MT..........HYYQIKEEELNDICGG............NPAGAAVI.GAIGCASRGVKLGSR.....................-IGP..WGAVIGGV.GSAAV----cgyl............
Q8DRN0_STRR6/6-65               ......................MS..........QFEIMDTEMLACVEGG............------GC.NWGDFAKAGVGGGAVrg.................lqLGIK..TRTWQGAA.TGAAGGAIL................
LAFX_LACJO/1-57                 .....................m--..........---KLNDKELSKIVGG............----NRWG.DTVLSAASGAGTGIKa..................ckSFGP..WGMAICGV.GGAAIGGYF................
G5JXF5_9STRE/6-67               ......................FE..........QFDVMNKETLSAIEGG............KMGDACLS.AGAASLAAGAGALASsa.................vpVVSM..YLGAQ---.---------alatgatl........
Q8DS95_STRMU/6-72               ......................FE..........QFNVMDNEALSAVEGG............----GRGW.NCAAGIALGAGQGYMata...............ggtAFLG..PYAIGTGA.FGAIAGGI-ggal............
A5CZV1_PELTS/2-61               ......................LE..........QSDELSEEELEQVAGG............-------G.VLALVALGLYAAGAT.....................---A..VGVGVGAV.AGAALAG--avvgvtalvg......
Q9PCT5_XYLFA/1-72               ..mdiailvyrdvylnsfkesl--..........KMRELTFEEALKVDGQ............--------.GWAGAFLTGAGTGAY.....................AGGL..IAEVPGAV.VGAVVGGV-i...............
C0MFS4_STRS7/6-73               .....................i-E..........QFSTMIADMLASVEGG............NCIWHDFT.Q--AAVFSGAGNGFR.....................LGVK..TRTWQGAA.AGAAGGL--vigavgygsv......
Q1WQX7_LACS1/2-62               ......................MK..........EFTVLTECELAKVDGG............KRGPNCVG.NFLGGLFAGAAAGVP.....................-LGP..AGIVGGAN.LGMVGGAL-t...............
#=GC seq_cons                   .......................c..........pFchlsp-pLupVpGG................tsss.shssuussGussGss......................h....hhss.uss.hGuh.Gh..h...............
//
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