GenomeNet

Database: Pfam
Entry: Bacteriocin_IIc
LinkDB: Bacteriocin_IIc
Original site: Bacteriocin_IIc 
#=GF ID   Bacteriocin_IIc
#=GF AC   PF10439.8
#=GF DE   Bacteriocin class II with double-glycine leader peptide
#=GF AU   Coggill P
#=GF SE   Manual
#=GF GA   27.00 27.00;
#=GF TC   27.20 27.00;
#=GF NC   26.90 26.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17074857
#=GF RT   The blp bacteriocins of Streptococcus pneumoniae mediate
#=GF RT   intraspecies competition both in vitro and in vivo. 
#=GF RA   Dawid S, Roche AM, Weiser JN; 
#=GF RL   Infect Immun. 2007;75:443-451.
#=GF RN   [2]
#=GF RM   17298586
#=GF RT   Diversity of enterococcal bacteriocins and their grouping in a
#=GF RT   new classification scheme. 
#=GF RA   Franz CM, van Belkum MJ, Holzapfel WH, Abriouel H, Galvez A; 
#=GF RL   FEMS Microbiol Rev. 2007;31:293-310.
#=GF DR   INTERPRO; IPR019493;
#=GF CC   This is a family of bacteriocidal bacteriocins secreted by
#=GF CC   Streptococcal species in order to kill off closely-related
#=GF CC   competitor Gram-positives. The sequence includes the peptide
#=GF CC   precursor, this being cleaved off proteolytically at the
#=GF CC   double-glycine. The family does not carry the YGNGVXC motif
#=GF CC   characteristic of pediocin-like Bacteriocins, Bacteriocin_II
#=GF CC   Pfam:PF01721. The producer bacteria are protected from the
#=GF CC   effects of their own bacteriocins by production of a specific
#=GF CC   immunity protein which is co-transcribed with the genes encoding
#=GF CC   the bacteriocins, eg family EntA_Immun Pfam:PF08951. The
#=GF CC   bacteriocins are structurally more specific than their
#=GF CC   immunity-protein counterparts. Typically, production of the
#=GF CC   bacteriocin gene is from within an operon carrying up to 6 genes
#=GF CC   including a typical two-component regulatory system (R and H), a
#=GF CC   small peptide pheromone (C), and a dedicated ABC transporter (A
#=GF CC   and -B) as well as an immunity protein [1]. The ABC transporter
#=GF CC   is thought to recognise the N termini of both the pheromone and
#=GF CC   the bacteriocins and to transport these peptides across the
#=GF CC   cytoplasmic membrane, concurrent with cleavage at the conserved
#=GF CC   double-glycine motif. Cleaved extracellular C can then bind to
#=GF CC   the sensor kinase, H, resulting in activation of R and
#=GF CC   up-regulation of the entire gene cluster via binding to
#=GF CC   consensus sequences within each promoter [2]. It seems likely
#=GF CC   that this whole regulon is carried on a transmissible plasmid
#=GF CC   which is passed between closely related Firmicute species since
#=GF CC   many clinical isolates from different Firmicutes can produce at
#=GF CC   least two bacteriocins. and the same bacteriocins can be
#=GF CC   produced by different species.
#=GF SQ   82
#=GS I5BT60_9BACT/1-80       AC I5BT60.1
#=GS Q8DWB6_STRMU/1-76       AC Q8DWB6.1
#=GS A0A139WTX4_9CYAN/1-70   AC A0A139WTX4.1
#=GS G6LSJ9_STREE/1-61       AC G6LSJ9.1
#=GS D9SPP3_CLOC7/1-70       AC D9SPP3.1
#=GS B9DTX8_STRU0/1-88       AC B9DTX8.1
#=GS Q5FI73_LACAC/1-64       AC Q5FI73.1
#=GS D5GZQ7_LACCS/1-62       AC D5GZQ7.1
#=GS A0A139NEU2_9STRE/3-63   AC A0A139NEU2.1
#=GS B7GL23_ANOFW/1-65       AC B7GL23.1
#=GS L0KCR9_HALHC/1-56       AC L0KCR9.1
#=GS Q8DSB5_STRMU/7-81       AC Q8DSB5.1
#=GS T1ZF76_STRIT/6-81       AC T1ZF76.1
#=GS T1ZF07_STRIT/6-72       AC T1ZF07.1
#=GS A0A172Q635_9STRE/1-59   AC A0A172Q635.1
#=GS R2S5N8_9ENTE/3-54       AC R2S5N8.1
#=GS Q9A138_STRP1/1-58       AC Q9A138.1
#=GS Q03ZY1_LEUMM/2-53       AC Q03ZY1.1
#=GS F9HJ90_9STRE/1-55       AC F9HJ90.1
#=GS Q8DWB7_STRMU/1-64       AC Q8DWB7.1
#=GS G6LSK0_STREE/2-49       AC G6LSK0.1
#=GS A0A0U3F8W2_9STRE/6-26   AC A0A0U3F8W2.1
#=GS Q035H7_LACC3/1-69       AC Q035H7.1
#=GS A0A085HK04_9GAMM/1-58   AC A0A085HK04.1
#=GS A0A0U3FA68_9STRE/6-76   AC A0A0U3FA68.1
#=GS J0VAD1_STREE/6-84       AC J0VAD1.1
#=GS B7GL22_ANOFW/1-86       AC B7GL22.1
#=GS A0A0U2UTJ8_9STRE/5-64   AC A0A0U2UTJ8.1
#=GS Q8DW08_STRMU/1-66       AC Q8DW08.1
#=GS S8BAT5_CLOBO/1-58       AC S8BAT5.1
#=GS I0XAR7_9SPIO/62-123     AC I0XAR7.1
#=GS A0A172Q613_9STRE/6-65   AC A0A172Q613.1
#=GS R2SSJ5_9ENTE/1-57       AC R2SSJ5.1
#=GS Q1WQX8_LACS1/1-65       AC Q1WQX8.1
#=GS L0KBX3_HALHC/1-64       AC L0KBX3.1
#=GS Q5M2W2_STRT2/6-69       AC Q5M2W2.1
#=GS A0A0U3DDL2_9STRE/5-62   AC A0A0U3DDL2.1
#=GS D9SSI4_CLOC7/1-70       AC D9SSI4.1
#=GS A0A139NHC3_9STRE/1-58   AC A0A139NHC3.1
#=GS C0MH64_STRS7/1-61       AC C0MH64.1
#=GS W7CPH2_9LIST/1-57       AC W7CPH2.1
#=GS Q8DRN0_STRR6/6-65       AC Q8DRN0.1
#=GS W7CGP1_9LIST/1-63       AC W7CGP1.1
#=GS A0A0U3F7F4_9STRE/6-76   AC A0A0U3F7F4.1
#=GS Q8DS95_STRMU/6-72       AC Q8DS95.1
#=GS A5CZV1_PELTS/2-61       AC A5CZV1.1
#=GS A0A139NEK0_9STRE/1-72   AC A0A139NEK0.1
#=GS C0MFS4_STRS7/6-73       AC C0MFS4.1
#=GS Q1WQX7_LACS1/2-62       AC Q1WQX7.1
#=GS J1P4N6_STREE/6-65       AC J1P4N6.1
#=GS A0A0U3DII5_9STRE/1-59   AC A0A0U3DII5.1
#=GS A0A145WNP8_9GAMM/30-71  AC A0A145WNP8.1
#=GS Q8DSA3_STRMU/1-62       AC Q8DSA3.1
#=GS T1ZF04_STRIT/6-65       AC T1ZF04.1
#=GS M9L947_PAEPP/1-82       AC M9L947.1
#=GS A0A172Q637_9STRE/6-62   AC A0A172Q637.1
#=GS C0MH63_STRS7/6-84       AC C0MH63.1
#=GS Q03D40_LACC3/1-65       AC Q03D40.1
#=GS B7GM69_ANOFW/1-58       AC B7GM69.1
#=GS F9P504_STRCV/6-72       AC F9P504.1
#=GS G6LRH6_STREE/1-64       AC G6LRH6.1
#=GS J0V0Y6_STREE/2-49       AC J0V0Y6.1
#=GS F5IUS8_9PORP/1-57       AC F5IUS8.1
#=GS D9SR35_CLOC7/1-57       AC D9SR35.1
#=GS Q8DSA2_STRMU/6-60       AC Q8DSA2.1
#=GS U2J410_9STRE/2-66       AC U2J410.1
#=GS C0MH54_STRS7/1-82       AC C0MH54.1
#=GS G6LSJ8_STREE/6-84       AC G6LSJ8.1
#=GS B2JC36_NOSP7/14-67      AC B2JC36.1
#=GS D7N233_9NEIS/1-72       AC D7N233.1
#=GS Q03D42_LACC3/1-65       AC Q03D42.1
#=GS Q8DSB1_STRMU/8-94       AC Q8DSB1.1
#=GS LAFA_LACJO/1-75         AC P24022.2
#=GS D9SR36_CLOC7/1-58       AC D9SR36.1
#=GS Q9A139_STRP1/2-63       AC Q9A139.1
#=GS B9JN18_AGRRK/1-51       AC B9JN18.1
#=GS G6ERX6_STRTR/6-77       AC G6ERX6.1
#=GS Q8DVP7_STRMU/6-73       AC Q8DVP7.1
#=GS LAFX_LACJO/1-57         AC Q48509.1
#=GS J1NZV6_STREE/1-61       AC J1NZV6.1
#=GS A0A139P7Q7_9STRE/1-77   AC A0A139P7Q7.1
#=GS Q9PCT5_XYLFA/1-72       AC Q9PCT5.1
I5BT60_9BACT/1-80                  mkggrflkilnrvgvkqnlfim--..........QFEELNNNELAEVNGG............-----LLG.GLLG.GVLGG..NN.SGQN.....................----..---ASGGLLGGFLGGL-lggnnsggfgs.....
Q8DWB6_STRMU/1-76                  ...............mewrintMEln......vnNYKSLTNDELSEVFGG............---DKQAA.DTFL.SAVGG..AA.SGFTyca...............sngVWHP..YILAGCAGVGAVGSVV-f...............
A0A139WTX4_9CYAN/1-70              .........maiikitelqsvn--..........QVEELSNEDLTSVVGG............-----LVG.GLLG.PTEPG..AA.GGGPf...................dIIPI..VGPLLSGLLGGFLGG--pa..............
G6LSJ9_STREE/1-61                  ..................mnty--..........--CNINETMLSEVYGG............----NSGG.AAVV.AALGC..AA.GGVKy..................grLLGP..WGAAIGGIGGAVVCGYL................
D9SPP3_CLOC7/1-70                  ......................MT..........NFETCTMDELVLIDGGdw.......swkSLAQSTVS.GAVG.GAIAG..SA.GGTV.....................TLPV..VGTVGGGVGGGILGAV-ggaa............
B9DTX8_STRU0/1-88                  ...mekllfqkrkvdilmnsni--..........EFDSIDTELLEKVIGG...........kNNWQANVS.GILA.AGAAG..AA.IGAPvcglac.........gyigakTAIT..LWAGVTGATGGF-----k...............
Q5FI73_LACAC/1-64                  ......................ME..........KLMVLNEEKLSYVIGGgnp......kvaHCASQIGR.STAW.GAVSG..AA.TGTA.....................----..VGQAVGALGGALFGGS-m...............
D5GZQ7_LACCS/1-62                  ......................MS..........KVEVLNEEELTTVVGGthskgfhpskgmKCLSGLTT.GFGI.GLM--..--.----.....................----..RGSAFGAAWGL------akasvl..........
A0A139NEU2_9STRE/3-63              ......................FE..........HFETLNENNLRDIYGG............NNAGAAVV.AAMS.CAAGG..IK.LGGK.....................-FGP..WGAAIGGVGGAAICGY-l...............
B7GL23_ANOFW/1-65                  ......................MR..........MFQELNHVELQGIDGGs.........wkSHVVNLVG.VVSG.FGTTG..AV.IGGS.....................FGGP..LGAAAGGFVGAHYGA--va..............
L0KCR9_HALHC/1-56                  ..............mnelstvg--..........NFEELSEDEYLNVDGG............---LVITG.TAVA.AGVGC..LA.GGVT.....................----..----VGYAIGT------viesv...........
Q8DSB5_STRMU/7-81                  ......................LE..........QFDAMDVDMLAAVEGGn.........wgQCIVGTGS.SALA.GGLAG..AG.TGAAvsapa...........aegggLGPI..AGAAIGWDLGAISGAGL................
T1ZF76_STRIT/6-81                  ......................LE..........KYEVLNSEMLASVEGG............YNTSDCLK.DYGK.GFLSG..TA.AGAA.....................-WGS..IAGGIGALPGAFVGAHVgiiggglacignmlg.
T1ZF07_STRIT/6-72                  ......................LE..........KFEVLNSEMLASVEGGkrp.....ggapVTGMTQAH.YTCL.AATWG..AT.FGGM.....................LAPIslIGSV-------------pgvlaacsg.......
A0A172Q635_9STRE/1-59              ......................ME..........QFQLIEDNELEMIVGG............KVSPTCAA.LVAA.SIYGG..LA.IAGP.....................----..VGVGVAMATGGVAAGS-fc..............
R2S5N8_9ENTE/3-54                  ......................ME..........KTKVLNVKEMKKVIGGn.........dvSCAVGIAV.GAGA.GGVIG..AI.GGLL.....................----..-----------------tecvqwgy........
Q9A138_STRP1/1-58                  ......................MD..........NFLELQFEELVNISGGkg.......nigSAIGGCLG.GMLI.AAAGG..PI.TGGA.....................----..-AAFVCVASG-------iaa.............
Q03ZY1_LEUMM/2-53                  ..............hkndlinf-S..........NFSQLDEYQLASVDGG............FIPVAVWA.LWAG.AGAAG..FS.GGIA.....................----..-----------------vgln............
F9HJ90_9STRE/1-55                  ..............mkplnkmd-E..........QFYVLSDEEMATVEGG............------GI.LFGI.VIVGG..II.VGGT.....................----..------FVLGAIDGA--mgar............
Q8DWB7_STRMU/1-64                  .................mdtqaFE..........QFDVMDSQTLSTVEGG............--------.-KVS.GGEAV..AA.IGIC.....................----..--ATASAAIGGLAGAT-lvtpycvgtwgli...
G6LSK0_STREE/2-49                  ..................dtkmMS..........QFAVMDNEMLACVEGGdi........dwG----RKI.SCAA.GVAYG..AI.DGC-.....................----..-----------------attv............
A0A0U3F8W2_9STRE/6-26              ......................FE..........QFDVMTDEALSTVEGG............--------.----.-----..--.----.....................----..-----------------kti.............
Q035H7_LACC3/1-69                  ...................msy--..........NYRQIDDFQLSGVSGG............KKKFDCAA.TFVT.GITAG..IG.SGTI.....................-TGL..AGGPFGIIGGAVVGGNLgavgsai.........
A0A085HK04_9GAMM/1-58              ......................--..........-MRELNKNEMEAVNGG............-----CIE.GALD.GAACA..SA.IGQSkg................wdgFSSF..VFSAFGAAVGAVVG---sd..............
A0A0U3FA68_9STRE/6-76              ......................FE..........QFDVMTDAELAKVEGG............---NKCVN.AIFG.GSLTG..AG.SGFV.....................-GGM..ATLGVTSIPGAFVGAHFgaiagglycvgas...
J0VAD1_STREE/6-84                  ......................ME..........QFHEMDITMLSSIEGG...........kNNWQTNVL.EGGG.AAFGG..WG.LGTAicaasgvgapfmgacgyigakFGVD..LWAGVTGATGG------f...............
B7GL22_ANOFW/1-86                  ..............megvvftm-Elml...ekngSISFLSEEELKEIDGGrgs.....wtnaVIGAGTLS.PIVA.SAVRG..AQ.QGVRf..................grLGGP..WGVVAGAVVGAVVGGYL................
A0A0U2UTJ8_9STRE/5-64              .....................i-E..........QFEVMSTEMLASIEGG...........nKISAGEAG.TALGiCTAGG..AA.VGAV.....................----..FGSAPGAIAGGVYGAQ-f...............
Q8DW08_STRMU/1-66                  .................mdtmaFE..........NFDEIDMNHLASIEGG............-------F.DVKG.VAASY..LA.MGTA.....................--AL..GGLACTTPVGAV-----lylgaevcagaav...
S8BAT5_CLOBO/1-58                  .....................m--..........--ENINLNELQEINGG............----MTAG.GVLY.ATGKG..AV.TGAL.....................TGAG..FGGAPGAILGAVYGAP-fgal............
I0XAR7_9SPIO/62-123                ...............seqtkes-E..........NTEYLSEDALEEVAGGs..........vTSWMHRNK.DWVI.AATAL..AT.IGAC.....................----..-----------------ymfnkylekksaa...
A0A172Q613_9STRE/6-65              ......................FE..........QFATLTDAELSAVEGG...........gCNWRDADK.AGVA.GGIGG..LI.GGGP.....................VGGI..AGIAGG-----------laaygatc........
R2SSJ5_9ENTE/1-57                  ......................MQ..........NVKELNIQKMQKITGG............---NSCTN.GTIG.GAIAG..AP.GGPL.....................-SFL..AGAAGGAVAGGC-----ikfg............
Q1WQX8_LACS1/1-65                  ................mknldk--..........RFTIMTEDNLASVNGGkngy....ggsgNRWVHCGA.GIVG.GALIG..AI.GGPW.....................----..-----SAVAGGISGGF-t...............
L0KBX3_HALHC/1-64                  ..............mdnlasvg--..........-MVELNEEELMMVDGG............---FFSVT.DLGW.AAAGG..AI.SGAI.....................TYGS..IGGAPGAVAGAFTGAAL................
Q5M2W2_STRT2/6-69                  .....................i-E..........NFNTLDLETLASVEGG............------GC.SWGG.FAKQG..VA.TGVGng.................lrLGIK..TRTWQGAVAGAAGGAIVggvg............
A0A0U3DDL2_9STRE/5-62              .....................mLE..........QFDVMTEAELSTVEGG............KSKEGRNM.GCIL.GTAGM..AG.AGFL.....................VAGP..AGAAALGG---------atal............
D9SSI4_CLOC7/1-70                  ................mnllvn-E..........NFTDLRIDEIEFINGGm.........sdWDWVWCGV.VTAG.CTVIG..AA.IGTA.....................VCPG..IGTIGGANAGSVLGGIF................
A0A139NHC3_9STRE/1-58              ................mttqiv-K..........KFETLDIETLSHVEGG............VNWAACYA.GTIG.SALVG..SA.GGPV.....................----..-GYWGGALVG-------yat.............
C0MH64_STRS7/1-61                  ......................MT..........HYYQIKEEELNDICGG............NPAGAAVI.GAIG.CASRG..VK.LGSR.....................-IGP..WGAVIGGVGSAAV----cgyl............
W7CPH2_9LIST/1-57                  ..................mkke--..........---LLNKNEMSRIIGG............---KINWG.NVGG.SCVGG..AV.IGGA.....................LGGL..GGAGGGCITGAIGS---iw..............
Q8DRN0_STRR6/6-65                  ......................MS..........QFEIMDTEMLACVEGG............------GC.NWGD.FAKAG..VG.GGAVrg.................lqLGIK..TRTWQGAATGAAGGAIL................
W7CGP1_9LIST/1-63                  ......................MH..........KVKKLNNQELQQIVGGys........skDCLKDIGK.GIGA.GTVAG..AA.GGGL.....................----..-AAGLGAIPGAFVGAHFgv..............
A0A0U3F7F4_9STRE/6-76              ......................FE..........QFDVMTDAELSAVEGG...........gCNWKGAAA.TVAV.GAVGG..AI.KGAV.....................TTYS..WQGAALKAVG-------ygikagvaygvtcrw.
Q8DS95_STRMU/6-72                  ......................FE..........QFNVMDNEALSAVEGG............----GRGW.NCAA.GIALG..AG.QGYMata...............ggtAFLG..PYAIGTGAFGAIAGGI-ggal............
A5CZV1_PELTS/2-61                  ......................LE..........QSDELSEEELEQVAGG............-------G.VLAL.VALGL..YA.AGAT.....................---A..VGVGVGAVAGAALAG--avvgvtalvg......
A0A139NEK0_9STRE/1-72              .................manvd-K..........QFQVLTAEELMEIHGGn.........nyGHYNPSAQ.DILK.AAASG..AIqVGATc...................lPAGA..WAVAGCALVGGLWGGY-i...............
C0MFS4_STRS7/6-73                  .....................i-E..........QFSTMIADMLASVEGG............NCIWHDFT.Q--A.AVFSG..AG.NGFR.....................LGVK..TRTWQGAAAGAAGGL--vigavgygsv......
Q1WQX7_LACS1/2-62                  ......................MK..........EFTVLTECELAKVDGG............KRGPNCVG.NFLG.GLFAG..AA.AGVP.....................-LGP..AGIVGGANLGMVGGAL-t...............
J1P4N6_STREE/6-65                  ......................MS..........QFEIMDTEMLACVEGG............------GC.NWGD.FAKAG..VG.GGAArg.................lqLGIK..TRTWQGAATGAVGGAIL................
A0A0U3DII5_9STRE/1-59              ......................ME..........QFQIIEENELEMIVGG............KVSPTCAA.LVAA.SIYGG.lAV.AGPA.....................GVGL..AMAVGGAAAGSF-----c...............
A0A145WNP8_9GAMM/30-71             .................skksr--..........----------------............------FS.PTVK.GALIG..AA.AGSV.....................-LPV..FGTISGAVIGAVSG---kiy.............
Q8DSA3_STRMU/1-62                  ......................MEkq......ynNFKILNTDALENIQGGgr.......aprCAALVGAS.IYDG.LAVVG..DP.VGVA.....................----..-MAAGTIAAGSF-----c...............
T1ZF04_STRIT/6-65                  ......................LE..........KFEALNSEMLARVEGG............------GC.NWGD.FAKSG..IA.GGAGng.................lrLGIK..TRTWQGVVAGAIIGGV-g...............
M9L947_PAEPP/1-82                  ......................MS..........RFVELNRNELEQVDGGgfsw....eglgKCVAGTAG.GVVA.GGTSG..FL.AGVSagrag..........gpqataAGGT..IGGVGGAIGGGLTGA--aas.............
A0A172Q637_9STRE/6-62              ......................LE..........QFVTLTDTELSAVEGG............KNKDGRDL.ACVL.GTAGM..AG.AGFL.....................FAGP..GGAA---VLGG------atal............
C0MH63_STRS7/6-84                  ......................MK..........QFEIIDADKLAHVEGG...........kNNWQTNVW.EGGT.AAVGG..WT.LGTTicaasgagapfmgacgyigakFGVS..LWAGVTGATGGF-----................
Q03D40_LACC3/1-65                  ......................MS..........KTRKLSELELQQFVGG............SDSNKCLM.GLVG.GWAIG..GL.NGAGs..................lsGFGP..AGVTIGGLYGTLSGIL-t...............
B7GM69_ANOFW/1-58                  ......................--..........-MKELKADELVSIDGG............--ISACGKvSVAA.FAHTA..AF.TGLM.....................TFAG..VSGPVGWVLGTFVGGA-w...............
F9P504_STRCV/6-72                  ......................LE..........KFEVLNSEMLASVEGGkrp.....ggapVTGMTQAH.YTCL.AATWG..AT.FGGM.....................LAPIslIGSV-------------pgvlaacsg.......
G6LRH6_STREE/1-64                  ......................MS..........QFEIMDTEMLACVEGG............------GC.NWGD.FAKAG..VG.GGAVrg.................lqLGIK..TRTWQGAATGAAGGAILggva............
J0V0Y6_STREE/2-49                  ..................dtkmMS..........QFAVMDNEMLACVEGGdi........dwG----RKI.SCAA.GVAYG..AI.DGC-.....................----..-----------------attv............
F5IUS8_9PORP/1-57                  .....................m-EkelttlnetsEFKELTKEEMAAINGGya........igDYLKDLYE.SAGA.AVAAG..AA.AGAA.....................----..-----------------ai..............
D9SR35_CLOC7/1-57                  ......................ME..........NFVSLTEVELHEIEGGrw........swKKIAKVAF.AVIK.TATTI..AS.GGAV.....................---I..PAVI-------------kgaitii.........
Q8DSA2_STRMU/6-60                  ......................LE..........QFDVMDSQVPSAIEGG............------GC.SWKG.ADKAG..FS.GGVG.....................---G..LIGAGGNPVGGVLGIA-ggl.............
U2J410_9STRE/2-66                  ................mktqai-E..........KFDVMDTEALSTVEGG............-----GTG.ACLA.SAATA..IG.LGAAavgs.............svlpAAAL..YLGAQAFAAGA------n...............
C0MH54_STRS7/1-82                  ...............mntetin--..........QFDVMNIEALATVEGG............YSGKDCLK.DMGG.YMLIG..AG.SGAL.....................-WGA..PAGGIGVLPGAFVGAHVgtigggfacmggmign
G6LSJ8_STREE/6-84                  ......................ME..........QFHEMDITMLSSIEGG...........kNNWQTNVL.EGGG.AAFGG..WG.LGTAicaasgvgapfmgacgyigakFGVD..LWAGVTGATGG------f...............
B2JC36_NOSP7/14-67                 .................ekevl--..........-LSELSDEEMATIQGG............--SNAPAE.VLAV.CAVGG..AV.LGGP.....................----..----AGFLGGAFVGAIL................
D7N233_9NEIS/1-72                  .............mqafyadkt--..........EIRTLSMDELSLVAGGf..........nWDKVQWGK.AVAV.GAVTG..LS.AGVA....................gLTGG..PGVAAAAAAGGFVGGF-g...............
Q03D42_LACC3/1-65                  ......................MK..........DVSVLNVTELAQVTGGg.........igKCIAGTVG.GGVM.GALTG..GG.LGSK.....................TKNL..YVIGGLGILGGVGGAIY................
Q8DSB1_STRMU/8-94                  ...........dkmdemriymm-Eik.....aldQFETMDTDMLAAVEGGfgwds..iwrgfKCVAGTAG.TIGT.GALGG..SA.TGGL.....................TLPI..IGHVSGGIIGGISGAGV................
LAFA_LACJO/1-75                    ......................MK..........QFNYLSHKDLAVVVGG...........rNNWQTNVG.GAVG.SAMIG..AT.VGGTicgpac.........avagahYLPI..LWTAVTAATGGFGKI--rk..............
D9SR36_CLOC7/1-58                  ......................ME..........NFKTLSEVELHQIDGGkw........kwKKIIKIAA.AVAG.TVVTI..AS.GGAA.....................----..---APAVIGGAI-----avan............
Q9A139_STRP1/2-63                  ...................ikf--..........-AEEIQKEELFHIIGG............YSATDCKN.HLIG.GITSG..AI.AGGV.....................GAGM..ATLGVGGVAGAFAGAHV................
B9JN18_AGRRK/1-51                  ......................MS..........NITEINADMLDLVSGG............---ASTVA.STVT.IGADG..AV.SGSY.....................TFGS..-----------------rsgtfsatl.......
G6ERX6_STRTR/6-77                  .....................i-E..........NFNTLDLETLASVEGG...........gCSWGGTGG.ATVQ.GAIGG..AF.GGNV.....................VLPV..VGSVPGYLAGGVLGGA-ggtvaygatc......
Q8DVP7_STRMU/6-73                  ......................FE..........QFNVMDNEALSTVEGGg.........miRCALGTAG.SAGL.GFVGG..MG.AGTV.....................TLPV..VGTVSGAALGGWSGAAVgaa.............
LAFX_LACJO/1-57                    .....................m--..........---KLNDKELSKIVGG............----NRWG.DTVL.SAASG..AG.TGIKa..................ckSFGP..WGMAICGVGGAAIGGYF................
J1NZV6_STREE/1-61                  ..................mnty--..........--CNINETMLSEVYGG............----NSGG.AAVV.AALGC..AA.GGVKy..................grLLGP..WGAAIGGIGGAVVCGYL................
A0A139P7Q7_9STRE/1-77              ................mttkti-S..........QFDVMDENMLAAVEGGgv........dwGKAVSCAG.SIAM.GAMEGygMA.AGST....................iYLGP..FAIGTGAVGGIIGGI--ggafy...........
Q9PCT5_XYLFA/1-72                  ..mdiailvyrdvylnsfkesl--..........KMRELTFEEALKVDGQ............--------.GWAG.AFLTG..AG.TGAY.....................AGGL..IAEVPGAVVGAVVGGV-i...............
#=GC seq_cons                      .......................p..........pFphlspcpLupVpGG................ttss.shss.uuhsG..us.sGss......................h....htsshuuhsGuh.s...h...............
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