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Database: Pfam
Entry: Bacteriocin_IId
LinkDB: Bacteriocin_IId
Original site: Bacteriocin_IId 
#=GF ID   Bacteriocin_IId
#=GF AC   PF09221.7
#=GF DE   Bacteriocin class IId cyclical uberolysin-like
#=GF PI   Bacterioc_AS-48;
#=GF AU   Sammut SJ, Coggill P, Eberhardt R
#=GF SE   pdb_1o82
#=GF GA   23.50 23.50;
#=GF TC   24.20 25.10;
#=GF NC   22.00 23.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   12620847
#=GF RT   Identification and characterization of two novel clostridial
#=GF RT   bacteriocins, circularin A and closticin 574.
#=GF RA   Kemperman R, Kuipers A, Karsens H, Nauta A, Kuipers O, Kok J;
#=GF RL   Appl Environ Microbiol. 2003;69:1589-1597.
#=GF RN   [2]
#=GF RM   14623193
#=GF RT   Structure of bacteriocin AS-48: from soluble state to membrane
#=GF RT   bound state.
#=GF RA   Sanchez-Barrena MJ, Martinez-Ripoll M, Galvez A, Valdivia E,
#=GF RA   Maqueda M, Cruz V, Albert A;
#=GF RL   J Mol Biol. 2003;334:541-549.
#=GF RN   [3]
#=GF RM   17464077
#=GF RT   Uberolysin: a novel cyclic bacteriocin produced by Streptococcus
#=GF RT   uberis.
#=GF RA   Wirawan RE, Swanson KM, Kleffmann T, Jack RW, Tagg JR;
#=GF RL   Microbiology. 2007;153:1619-1630.
#=GF RN   [4]
#=GF RM   15544534
#=GF RT   The circular bacteriocins gassericin A and circularin A.
#=GF RA   Kawai Y, Kemperman R, Kok J, Saito T;
#=GF RL   Curr Protein Pept Sci. 2004;5:393-398.
#=GF RN   [5]
#=GF RM   19692336
#=GF RT   The three-dimensional structure of carnocyclin A reveals that
#=GF RT   many circular bacteriocins share a common structural motif.
#=GF RA   Martin-Visscher LA, Gong X, Duszyk M, Vederas JC;
#=GF RL   J Biol Chem. 2009;284:28674-28681.
#=GF DR   INTERPRO; IPR020038;
#=GF DR   SCOP; 1o82; fa;
#=GF DR   TC; 1.C.28;
#=GF CC   Members of this family are membrane-interacting peptides,
#=GF CC   produced by Firmicutes that display a broad anti-microbial
#=GF CC   spectrum against Gram-positive and Gram-negative bacteria. They
#=GF CC   adopt a helical structure, with four or five alpha helices
#=GF CC   forming a Saposin-like fold [2,5].  The structure has been found
#=GF CC   to be cyclical [1, 3, 5]. It should be pointed out that one
#=GF CC   reference [4] implies that both circularin A and gassericin A
#=GF CC   are class V or IIc-type bacteriocins; however we find that these
#=GF CC   two proteins fall into different Pfam families families, this
#=GF CC   one and BacteriocIIc_cy, Pfam:PF12173.
#=GF SQ   12
#=GS Q5L226_GEOKA/8-76        AC Q5L226.1
#=GS V9WBZ6_9BACL/47-109      AC V9WBZ6.1
#=GS V9WDA0_9BACL/5-73        AC V9WDA0.1
#=GS A0A077J5A4_9BACI/37-105  AC A0A077J5A4.1
#=GS G2TKB0_BACCO/50-112      AC G2TKB0.1
#=GS A4XGX2_CALS8/5-74        AC A4XGX2.1
#=GS H2J5C1_MARPK/30-92       AC H2J5C1.1
#=GS K8EIV9_CARML/9-72        AC K8EIV9.2
#=GS G0HDB9_CORVD/44-101      AC G0HDB9.1
#=GS A8FIF2_BACP2/9-71        AC A8FIF2.1
#=GS B9DSR7_STRU0/8-76        AC B9DSR7.1
#=GS N0APL7_9BACI/5-73        AC N0APL7.1
Q5L226_GEOKA/8-76                   ..AGTLGVSQSIATTVVSIVLTGSTLISIILGITAILSGGVd.aILEIGWSA..FVATVKKIVAERGKAAAIAW
V9WBZ6_9BACL/47-109                 ..ASTLGISTAAAKKAIDIIDAASTIASIISLIGIVTGAGA...VSYA----..IVATAKTMIKKYGKKYAAAW
V9WDA0_9BACL/5-73                   ..AGYFGISTGMAKKIVDVIDAAGWAFVAVSTIMAILSAGG...LAVTSAMVdyAIIYVKDLLKRNLKAQAIVW
A0A077J5A4_9BACI/37-105             ak--EFGVPSAVGSVVAWYLDLGAAASIIIGLLTGFLSGGLg.lIAAAGRET..LKAFLLAELRKRGTKAFVAW
G2TKB0_BACCO/50-112                 ..ASTLGISTAAAKKAIDIIDTASTIASIISLIGVVTGAGA...ISYA----..VVATAKAMIKKYGKKYAAAW
A4XGX2_CALS8/5-74                   ..AATLGIPETLATTIVNIILTGSTIVSIILALTSILTAGVsavILAGGWTA..FINLVKSKVAQLGLRGAILW
H2J5C1_MARPK/30-92                  ..ASMLGISKHAAEKVIDIIDTFSTVTTIISIITAVIGAGA...ITAG----..LVAVAKKMIKKYGKRYATMW
K8EIV9_CARML/9-72                   ..ASSMGISWGVASKVIDLVLAGSSAWAIVA---AIVSGGG...IIAIGAVA..IKALIQSKLKQMGRAAVITW
G0HDB9_CORVD/44-101                 ..AGQLGISAAAASQVVNAIDKGGWALAAVG---ALVG-GG...ISGA----..IIATTRAIIVKKGKTVAAA-
A8FIF2_BACP2/9-71                   ..AANLGVSTATAATVVNFLDTWSSVATVITIVGVFTGVGT...ISSG----..VAATILAILKKQGKAKAAAF
B9DSR7_STRU0/8-76                   ..AGYTGIASGTAKKVVDAIDKGAAAFVIISIISTVISAGA...LGAVSASAdfIILTVKNYISRNLKAQAVIW
N0APL7_9BACI/5-73                   .m-GFFGVGKTLATQIVNVVDAVGYAAIAVSTIMAILSAGG...LAPTAAAIdfAIIYIKKKIANNLKAQAIVW
#=GC seq_cons                       ..AuphGISpusAppllsllDsuusshsIIuhlsulluuGu...Iuss......llAhlKshlp+hGKttAhsW
//
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