GenomeNet

Database: Pfam
Entry: Bacteriocin_IId
LinkDB: Bacteriocin_IId
Original site: Bacteriocin_IId 
#=GF ID   Bacteriocin_IId
#=GF AC   PF09221.5
#=GF DE   Bacteriocin class IId cyclical uberolysin-like
#=GF PI   Bacterioc_AS-48;
#=GF AU   Sammut SJ, Coggill P, Eberhardt R
#=GF SE   pdb_1o82
#=GF GA   23.00 23.00;
#=GF TC   23.30 23.00;
#=GF NC   22.00 21.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   12620847
#=GF RT   Identification and characterization of two novel clostridial
#=GF RT   bacteriocins, circularin A and closticin 574.
#=GF RA   Kemperman R, Kuipers A, Karsens H, Nauta A, Kuipers O, Kok J;
#=GF RL   Appl Environ Microbiol. 2003;69:1589-1597.
#=GF RN   [2]
#=GF RM   14623193
#=GF RT   Structure of bacteriocin AS-48: from soluble state to membrane
#=GF RT   bound state.
#=GF RA   Sanchez-Barrena MJ, Martinez-Ripoll M, Galvez A, Valdivia E,
#=GF RA   Maqueda M, Cruz V, Albert A;
#=GF RL   J Mol Biol. 2003;334:541-549.
#=GF RN   [3]
#=GF RM   17464077
#=GF RT   Uberolysin: a novel cyclic bacteriocin produced by Streptococcus
#=GF RT   uberis.
#=GF RA   Wirawan RE, Swanson KM, Kleffmann T, Jack RW, Tagg JR;
#=GF RL   Microbiology. 2007;153:1619-1630.
#=GF RN   [4]
#=GF RM   15544534
#=GF RT   The circular bacteriocins gassericin A and circularin A.
#=GF RA   Kawai Y, Kemperman R, Kok J, Saito T;
#=GF RL   Curr Protein Pept Sci. 2004;5:393-398.
#=GF RN   [5]
#=GF RM   19692336
#=GF RT   The three-dimensional structure of carnocyclin A reveals that
#=GF RT   many circular bacteriocins share a common structural motif.
#=GF RA   Martin-Visscher LA, Gong X, Duszyk M, Vederas JC;
#=GF RL   J Biol Chem. 2009;284:28674-28681.
#=GF DR   INTERPRO; IPR020038;
#=GF DR   SCOP; 1o82; fa;
#=GF DR   TC; 1.C.28;
#=GF CC   Members of this family are membrane-interacting peptides,
#=GF CC   produced by Firmicutes that display a broad anti-microbial
#=GF CC   spectrum against Gram-positive and Gram-negative bacteria. They
#=GF CC   adopt a helical structure, with four or five alpha helices
#=GF CC   forming a Saposin-like fold [2,5].  The structure has been found
#=GF CC   to be cyclical [1, 3, 5]. It should be pointed out that one
#=GF CC   reference [4] implies that both circularin A and gassericin A
#=GF CC   are class V or IIc-type bacteriocins; however we find that these
#=GF CC   two proteins fall into different Pfam families families, this
#=GF CC   one and BacteriocIIc_cy, Pfam:PF12173.
#=GF SQ   111
#=GS H7K9Y3_STRPN/19-81   AC H7K9Y3.1
#=GS D4RUA8_ENTFC/25-87   AC D4RUA8.1
#=GS CCLA_CARML/5-64      AC B2MVM5.1
#=GS CCLA_CARML/5-64      DR PDB; 2KJF A; 1-60;
#=GS G6S5F1_STRPN/36-98   AC G6S5F1.1
#=GS E9FQC9_9STRE/36-98   AC E9FQC9.1
#=GS C9BRP5_ENTFC/25-87   AC C9BRP5.1
#=GS C3EE61_BACTU/34-99   AC C3EE61.1
#=GS E2YGW1_ENTFL/33-95   AC E2YGW1.1
#=GS A7Z8C8_BACA2/50-112  AC A7Z8C8.1
#=GS G6KA67_STRPN/36-98   AC G6KA67.1
#=GS H7KT96_STRPN/36-98   AC H7KT96.1
#=GS G0ILR6_BACAM/50-112  AC G0ILR6.1
#=GS G8N719_GEOTH/8-76    AC G8N719.1
#=GS G6JKG6_STRPN/36-98   AC G6JKG6.1
#=GS D7D2D1_GEOSC/8-76    AC D7D2D1.1
#=GS H7QL21_STRPN/36-98   AC H7QL21.1
#=GS G6UP78_STRPN/36-98   AC G6UP78.1
#=GS F8FLY6_PAEMK/7-69    AC F8FLY6.1
#=GS G6TJW1_STRPN/36-98   AC G6TJW1.1
#=GS B5V861_BACCE/7-75    AC B5V861.1
#=GS G4CXQ0_9ACTO/11-68   AC G4CXQ0.1
#=GS G2TKB0_BACCO/50-112  AC G2TKB0.1
#=GS C0M842_STRE4/45-106  AC C0M842.1
#=GS A4XGX2_CALS8/5-74    AC A4XGX2.1
#=GS E8SVR1_GEOS2/8-64    AC E8SVR1.1
#=GS B1I7U4_STRPI/36-98   AC B1I7U4.1
#=GS D4ERH7_ENTFL/33-95   AC D4ERH7.1
#=GS I0SLD2_9STRE/36-98   AC I0SLD2.1
#=GS H7NGT7_STRPN/36-98   AC H7NGT7.1
#=GS B9DSR7_STRU0/8-76    AC B9DSR7.1
#=GS D5N1N0_BACPN/49-111  AC D5N1N0.1
#=GS E0U011_BACPZ/49-111  AC E0U011.1
#=GS Q5L226_GEOKA/8-76    AC Q5L226.1
#=GS G6L157_STRPN/36-98   AC G6L157.1
#=GS G6NYT3_STRPN/36-98   AC G6NYT3.1
#=GS G6LJN1_STRPN/36-98   AC G6LJN1.1
#=GS B2E044_STRPN/36-98   AC B2E044.1
#=GS G6J7G3_STRPN/36-98   AC G6J7G3.1
#=GS A8FIF2_BACP2/9-71    AC A8FIF2.1
#=GS E4JJJ4_ENTFC/25-87   AC E4JJJ4.1
#=GS O52963_ENTFL/37-105  AC O52963.1
#=GS H7I4Q6_STRPN/36-98   AC H7I4Q6.1
#=GS H7JCR6_STRPN/36-98   AC H7JCR6.1
#=GS H7LKL7_STRPN/36-98   AC H7LKL7.1
#=GS H7JX44_STRPN/36-98   AC H7JX44.1
#=GS G6PWG8_STRPN/36-98   AC G6PWG8.1
#=GS Q0SUX0_CLOPS/6-69    AC Q0SUX0.1
#=GS G6PPJ1_STRPN/36-98   AC G6PPJ1.1
#=GS F4ELM0_BACAM/50-112  AC F4ELM0.1
#=GS D4RGC3_ENTFC/25-87   AC D4RGC3.1
#=GS C9C5V8_ENTFC/25-87   AC C9C5V8.1
#=GS F4EA67_BACAM/49-111  AC F4EA67.1
#=GS Q8GB47_CLOBE/5-72    AC Q8GB47.1
#=GS F3VLN3_STRPN/36-98   AC F3VLN3.1
#=GS D0ARJ8_ENTFC/25-87   AC D0ARJ8.1
#=GS B9MPP9_ANATD/5-74    AC B9MPP9.1
#=GS B4AJB1_BACPU/34-96   AC B4AJB1.1
#=GS G9SRG7_ENTFC/26-88   AC G9SRG7.1
#=GS B4U083_STREM/45-102  AC B4U083.1
#=GS H2J5C1_MARPK/30-92   AC H2J5C1.1
#=GS H2ACN4_BACAM/50-112  AC H2ACN4.1
#=GS Q8KNQ6_BACTI/5-73    AC Q8KNQ6.1
#=GS G6RJA9_STRPN/36-98   AC G6RJA9.1
#=GS G6K3X9_STRPN/36-98   AC G6K3X9.1
#=GS D4EIP7_ENTFL/33-95   AC D4EIP7.1
#=GS G6UTF4_STRPN/36-98   AC G6UTF4.1
#=GS H7H8M9_STRPN/19-81   AC H7H8M9.1
#=GS C3IW40_BACTU/1-69    AC C3IW40.1
#=GS UBLA_STRUB/8-76      AC A5H1G9.1
#=GS G6MBM9_STRPN/36-98   AC G6MBM9.1
#=GS H0FPM2_BACAM/49-111  AC H0FPM2.1
#=GS H8XGI1_BACAM/50-112  AC H8XGI1.1
#=GS G6W8N7_STRPN/36-98   AC G6W8N7.1
#=GS G6SX46_STRPN/19-81   AC G6SX46.1
#=GS H7MKY4_STRPN/36-98   AC H7MKY4.1
#=GS C1CHE1_STRZJ/36-98   AC C1CHE1.1
#=GS G6MHV0_STRPN/36-98   AC G6MHV0.1
#=GS E2YRG2_ENTFL/33-95   AC E2YRG2.1
#=GS A5MY21_STRPN/36-98   AC A5MY21.1
#=GS B1BXT7_CLOPF/5-67    AC B1BXT7.1
#=GS G6LCX4_STRPN/36-98   AC G6LCX4.1
#=GS A5LXP4_STRPN/36-98   AC A5LXP4.1
#=GS F8IM19_STREC/25-87   AC F8IM19.1
#=GS D0AJL7_ENTFC/25-87   AC D0AJL7.1
#=GS G0IAT3_STRES/36-98   AC G0IAT3.1
#=GS C7WYP1_ENTFL/33-95   AC C7WYP1.1
#=GS F4BKZ6_CARS1/9-72    AC F4BKZ6.1
#=GS A5LIS8_STRPN/36-98   AC A5LIS8.1
#=GS G6J144_STRPN/36-98   AC G6J144.1
#=GS Q47765_ENTFL/37-105  AC Q47765.1
#=GS Q47765_ENTFL/37-105  DR PDB; 1O83 A; 2-70;
#=GS Q47765_ENTFL/37-105  DR PDB; 1O82 C; 2-70;
#=GS Q47765_ENTFL/37-105  DR PDB; 1O82 A; 2-70;
#=GS Q47765_ENTFL/37-105  DR PDB; 1O82 B; 2-70;
#=GS Q47765_ENTFL/37-105  DR PDB; 1O84 B; 2-70;
#=GS Q47765_ENTFL/37-105  DR PDB; 1O83 D; 2-70;
#=GS Q47765_ENTFL/37-105  DR PDB; 1O82 D; 2-70;
#=GS Q47765_ENTFL/37-105  DR PDB; 1E68 A; 2-70;
#=GS Q47765_ENTFL/37-105  DR PDB; 1O83 C; 2-70;
#=GS Q47765_ENTFL/37-105  DR PDB; 1O84 A; 2-70;
#=GS Q47765_ENTFL/37-105  DR PDB; 1O83 B; 2-70;
#=GS G6JEB8_STRPN/19-81   AC G6JEB8.1
#=GS H7LPS1_STRPN/36-98   AC H7LPS1.1
#=GS F8FLY9_PAEMK/5-64    AC F8FLY9.1
#=GS H7HEU6_STRPN/36-98   AC H7HEU6.1
#=GS G0HDB9_CORVD/44-101  AC G0HDB9.1
#=GS E1UPP4_BACAS/37-99   AC E1UPP4.1
#=GS C1C9U1_STRP7/36-98   AC C1C9U1.1
#=GS G6UFL3_STRPN/36-98   AC G6UFL3.1
#=GS B2DP83_STRPN/36-98   AC B2DP83.1
#=GS H1I378_9BACI/5-73    AC H1I378.1
#=GS B5V862_BACCE/7-75    AC B5V862.1
#=GS H7HYG1_STRPN/36-98   AC H7HYG1.1
#=GS I0W140_9STRE/36-98   AC I0W140.1
#=GS D2KC49_9LACT/4-63    AC D2KC49.1
#=GS C9RXM2_GEOSY/8-64    AC C9RXM2.1
#=GS A5MCD9_STRPN/36-98   AC A5MCD9.1
#=GS G6N7Y0_STRPN/36-98   AC G6N7Y0.1
#=GS H7J6K9_STRPN/36-98   AC H7J6K9.1
#=GS G5ELQ0_LEUME/4-63    AC G5ELQ0.1
#=GS G4P873_BACIU/49-111  AC G4P873.1
#=GS F0PZQ6_BACT0/34-99   AC F0PZQ6.1
H7K9Y3_STRPN/19-81              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
D4RUA8_ENTFC/25-87              ......s-ANIGISSYAAKKVIDIINTGSTVATIISIV.AAVVGGGLIT....---AGIVATAKSLIKKYGAKYAAAW.......
CCLA_CARML/5-64                 .....lv--AYGIAQGTAEKVVSLINAGLTVGSIISIL.GGVT------....VGLSGVFTAVKAAIAKQGIKKAIQ-l......
#=GR CCLA_CARML/5-64      SS    .....-T--TTTS-HHHHHHHHHHHTTT--HHHHHHHH.-SS-------....TTTHHHHHHHHHHHHHT-HHHHHH--......
G6S5F1_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
E9FQC9_9STRE/36-98              .......AGTLGISTGSAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYMLKKKSAAKAALW.......
C9BRP5_ENTFC/25-87              ......s-ANIGISSYAAKKVIDIINTGSTVATIISIV.AAVVGGGLIT....---AGIVATAKSLIKKYGAKYAAAW.......
C3EE61_BACTU/34-99              ......t-LQYDISAANAGRIVSALEWASDMGAVIGLA.GAILGAGIGA....AAVSAAVAIAKRRLLKEGKKAAVLY.......
E2YGW1_ENTFL/33-95              ......t-STLGISTYAAKKVIDIISAAGSVWSVVGIV.AAVVGGGGIG....---AAILVTAKSFVKRYGKAFATAW.......
A7Z8C8_BACA2/50-112             .......ASTLGISTAAAKKAIDIIDAASTIASIISLI.GIVTGAGAIS....---YAIVATAKTMIKKYGKKYAAAW.......
G6KA67_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
H7KT96_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
G0ILR6_BACAM/50-112             .......ASTLGISTAAAKKAIDIIDAASTIASIISLI.GIVTGAGAIS....---YAIVATAKTMIKKYGKKYAAAW.......
G8N719_GEOTH/8-76               .......AGTLGVSQAVATTVVSIVLTGSTLISIILGI.TAILSGGVDAi.leIGWSAFVATVKKIVAERGKAAAIAW.......
G6JKG6_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
D7D2D1_GEOSC/8-76               .......AGTLGVSQAVATTVVSIVLTGSTLISIILGI.TAILSGGVDAi.leIGWSAFVATVKKIVAERGKAAAIAW.......
H7QL21_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
G6UP78_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
F8FLY6_PAEMK/7-69               vsmglas-------YTVATTIVKLVSWGLTAASILSLI.ASLSGVGAIG....---VGVIEFIKREIWKQGAAKMVSW.......
G6TJW1_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
B5V861_BACCE/7-75               .......ASKFKVSQGIAGGVVAAVLNAGTLISAIGAV.TVVMSGGIDAi.leVGWTAFVATVKEQAAKRGTAGAVAW.......
G4CXQ0_9ACTO/11-68              .......AGMFGLSTSAASQIVNAVSVGGAALSIAMAV.AS---GG-IA....---AAAVATAKWAIKKWGKKVAIA-.......
G2TKB0_BACCO/50-112             .......ASTLGISTAAAKKAIDIIDTASTIASIISLI.GVVTGAGAIS....---YAVVATAKAMIKKYGKKYAAAW.......
C0M842_STRE4/45-106             .......AGALGISTANANTTVNLLSAYSTVSSVVAIV.GAVTGVGSIG....---AGIAATVLYLIKQKGKAA-ALW.......
A4XGX2_CALS8/5-74               .......AATLGIPETLATTIVNIILTGSTIVSIILAL.TSILTAGVSAvilaGGWTAFINLVKSKVAQLGLRGAILW.......
E8SVR1_GEOS2/8-64               .......AGTLGVSQAVATTVVSIVLTGSTLISIILGI.TAILSGGVDAi.leIGWSAFVATVKK-------------n......
B1I7U4_STRPI/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
D4ERH7_ENTFL/33-95              ......t-STLGISTYAAKKVIDIISAAGSVWSVVGIV.AAVVGGGGIG....---AAILVTAKSFVKRYGKAFATAW.......
I0SLD2_9STRE/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
H7NGT7_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
B9DSR7_STRU0/8-76               .......AGYTGIASGTAKKVVDAIDKGAAAFVIISII.STVISAGALGa.vsASADFIILTVKNYISRNLKAQAVIW.......
D5N1N0_BACPN/49-111             .......ASTLGISTAAAKKAIDIIDAASTVASIISLI.GIVTGAGAIS....---YAIVATAKSMIKKYGKKYAAAW.......
E0U011_BACPZ/49-111             .......ASTLGISTAAAKKAIDIIDAASTVASIISLI.GIVTGAGAIS....---YAIVATAKSMIKKYGKKYAAAW.......
Q5L226_GEOKA/8-76               .......AGTLGVSQSIATTVVSIVLTGSTLISIILGI.TAILSGGVDAi.leIGWSAFVATVKKIVAERGKAAAIAW.......
G6L157_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
G6NYT3_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
G6LJN1_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
B2E044_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
G6J7G3_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
A8FIF2_BACP2/9-71               .......AANLGVSTATAATVVNFLDTWSSVATVITIV.GVFTGVGTIS....---SGVAATILAILKKQGKAKAAAF.......
E4JJJ4_ENTFC/25-87              ......s-ANIGISSYAAKKVIDIINTGSTVATIISIV.AAVVGGGLIT....---AGIVATAKSLIKKYGAKYAAAW.......
O52963_ENTFL/37-105             .......AKEFGIPAAVAGTVLNVVEAGGWVTTIVSNL.TAVGSGGLSLl.aaAGRESIKAYLKKEIKKKGKRAVIAW.......
H7I4Q6_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
H7JCR6_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
H7LKL7_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
H7JX44_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
G6PWG8_STRPN/36-98              .......TGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
Q0SUX0_CLOPS/6-69               .......AALLGISSNWAMKIVDLIATGASIWAIAAAV.AA--SGGILA....IGIVVLRELVMKKIKQVGYAAAVTY.......
G6PPJ1_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
F4ELM0_BACAM/50-112             .......ASTLGISAAAAKKAIDIIDAASTIASIISLI.GIVTGAGAIS....---YAIVATAKTMIKKYGKKYAAAW.......
D4RGC3_ENTFC/25-87              ......s-ANIGISSYAAKKVIDIINTGSTVATIISIV.AAVVGGGLIT....---AGIVATAKSLIKKYGAKYAAAW.......
C9C5V8_ENTFC/25-87              ......s-ANIGISSYAAKKVIDIINTGSTVATIISIV.AAVVGGGLIT....---AGIVATAKSLIKKYGAKYAAAW.......
F4EA67_BACAM/49-111             .......ASTLGISTAAAKKAIDIIDAASTIASIISLI.GIVTGAGAIS....---YAIVATAKTMIKKYGKKYAAAW.......
Q8GB47_CLOBE/5-72               .......AGALGVQTAAATTIVNVILNAGTLVTVLGII.ASIASGGAGTl.mtIGWATFKATVQK-LAKQSMARAIAY.......
F3VLN3_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
D0ARJ8_ENTFC/25-87              ......s-ANIGISSYAAKKVIDIINTGSTVATIISIV.AAVVGGGLIT....---AGIVATAKSLIKKYGAKYAAAW.......
B9MPP9_ANATD/5-74               .......AATLGIPETLAVTIVNIILTGSTIVSIIIAL.TSILTAGVSAiileGGWTAFINLVKSKVAQLGLRGTILW.......
B4AJB1_BACPU/34-96              .......AANLGVSTATAATVVNFLDTWSSVATVITIV.GVFTGVGTIS....---SGVAAAILAILKKEGKAKAAAF.......
G9SRG7_ENTFC/26-88              ......s-ANIGISSYAAKKVIDIINTGSTVATIISIV.AAVVGGGLIT....---AGIVATAKSLIKKYGAKYAAAW.......
B4U083_STREM/45-102             .......AGALGISTSSASTTVNLLSAYSTVSSVIAIV.GAITGVGSIG....AGIAATVYTL---------------sntkerl
H2J5C1_MARPK/30-92              .......ASMLGISKHAAEKVIDIIDTFSTVTTIISII.TAVIGAGAIT....---AGLVAVAKKMIKKYGKRYATMW.......
H2ACN4_BACAM/50-112             .......ASTLGISTAAAKKAIDIIDAASTIASIISLI.GIVTGAGAIS....---YAIVATAKTMIKKYGKKYAAAW.......
Q8KNQ6_BACTI/5-73               .......MGYFGVDRGWATKIVNAIDAVGWGVAAASAI.AAIVTAGGLAv.tsAMIDVAIFTVKDFLRRNLKAQAVAW.......
G6RJA9_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
G6K3X9_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
D4EIP7_ENTFL/33-95              ......t-STLGISTYAAKKVIDIISAAGSVWSVVGIV.AAVVGGGGIG....---AAILVTAKSFVKRYGKAFATAW.......
G6UTF4_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
H7H8M9_STRPN/19-81              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
C3IW40_BACTU/1-69               .......MGYFGVDRGWATKIVNAIDAVGWGVAAASAI.AAIVTAGGLAv.tsAMIDVAIFTVKDFLRRNLKAQAVAW.......
UBLA_STRUB/8-76                 .......AGYTGIASGTAKKVVDAIDKGAAAFVIISII.STVISAGALGa.vsASADFIILTVKNYISRNLKAQAVIW.......
G6MBM9_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
H0FPM2_BACAM/49-111             .......ASTLGISTAAAKKAIDIIDAASTIASIISLI.GIVTGAGAIS....---YAIVATAKTMIKKYGKKYAAAW.......
H8XGI1_BACAM/50-112             .......ASTLGISTAAAKKAIDIIDAASTIASIISLI.GIVTGAGAIS....---YAIVATAKTMIKKYGKKYAAAW.......
G6W8N7_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
G6SX46_STRPN/19-81              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
H7MKY4_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
C1CHE1_STRZJ/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
G6MHV0_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
E2YRG2_ENTFL/33-95              ......t-STLGISTYAAKKVIDIISAAGSVWSVVGIV.AAVVGGGGIG....---AAILVTAKSFVKRYGKAFATAW.......
A5MY21_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
B1BXT7_CLOPF/5-67               .......AGMLGVDFYAAKKVIDIVATAGTVASVIGIV.AAVAGTGGIG....---VGILAAAKALAKKYGTKAAATW.......
G6LCX4_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
A5LXP4_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
F8IM19_STREC/25-87              .......AGALGISTANANTTVNLLSAYSTVSSVVAIV.GAVTGVGSIG....---AGIAATVLYLIKQKGKAAAALW.......
D0AJL7_ENTFC/25-87              ......s-ANIGISSYAAKKVIDIINTGSTVATIISIV.AAVVGGGLIT....---AGIVATAKSLIKKYGAKYAAAW.......
G0IAT3_STRES/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKSAAQAALW.......
C7WYP1_ENTFL/33-95              ......t-STLGISTYAAKKVIDIISAAGSVWSVVGIV.AAVVGGGGIG....---AAILVTAKSFVKRYGKAFATAW.......
F4BKZ6_CARS1/9-72               ....mns---MNIGRSTATHVIDLAVAGASAWAIVASI.AA--GGGIIA....IGAVAVRTLIKSKLKKLGYTALVAW.......
A5LIS8_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
G6J144_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
Q47765_ENTFL/37-105             .......AKEFGIPAAVAGTVLNVVEAGGWVTTIVSIL.TAVGSGGLSLl.aaAGRESIKAYLKKEIKKKGKRAVIAW.......
#=GR Q47765_ENTFL/37-105  SS    .......HHHHT--HHHHHHHHHHHHTT--HHHHHHHH.HHHSHHHHHHH.HHTTTS-HHHHHHHHHHHHHHHHHHH-.......
G6JEB8_STRPN/19-81              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
H7LPS1_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
F8FLY9_PAEMK/5-64               .....vq--HLGVTMATALAIVNAIKLGFTIAAIISLI.SGVG--GWIA....----FWYGSIQRKVWELGATAAAFW.......
H7HEU6_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
G0HDB9_CORVD/44-101             .......AGQLGISAAAASQVVNAIDKGGWALA---AV.GALVGGGISG....----AIIATTRAIIVKKGKTVAAA-.......
E1UPP4_BACAS/37-99              .......ASTLGISAAAAKKAIDIIDAASTIASIISLI.GIVTGAGAIS....---YAIVATAKTMIKKYGKKYAAAW.......
C1C9U1_STRP7/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
G6UFL3_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
B2DP83_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
H1I378_9BACI/5-73               ......m-GFFGVGKTLATQIVNVVDAVGYAAIAVSTI.MAILSAGGLAp.taAAIDFAIIYIKKKIANNLKAQAIVW.......
B5V862_BACCE/7-75               .......ASKLSISKGVAAGVVSTVLNAGTLITAIGAV.TVALSGGIDAi.leVGWATFVATVKEQAAKRGTAGAVAW.......
H7HYG1_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
I0W140_9STRE/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKSAAQAALW.......
D2KC49_9LACT/4-63               .....lv--ATGMAAGVAKTIVNAVSAGMDIATALSLFsGAFTAAGGIM....---ALIKKYAQKKLWKQLIA-----a......
C9RXM2_GEOSY/8-64               .......AGTLGVSQAVATTVVSIVLTGSTLISIILGI.TAILSGGVDAi.leIGWSAFVATVKK-------------n......
A5MCD9_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
G6N7Y0_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
H7J6K9_STRPN/36-98              .......AGTLGISTKAAATVVNLISAYSTVTAVISIV.GAITGVGSIG....---SGIAATVLYILKKKGAAKAALW.......
G5ELQ0_LEUME/4-63               .....vn--QLGISKSLANTILGAIA-VGNLASW--LL.ALVPGPGWAT....---KAALATAETIVKHEGKAAAIAW.......
G4P873_BACIU/49-111             .......ASTLGISTAAAKKAIDIIDAASTVASIISLI.GIVTGAGAIS....---YAIVATAKTMIKKYGKKYAAAW.......
F0PZQ6_BACT0/34-99              ......t-LQYDISAVNAGRIVSALEWASDMGAVIGLA.GAILGAGIGA....AAISAAVAIAKRKLLKEGKKAAVLY.......
#=GC SS_cons                    ......THHCCTS-HHHHHHHHHHHCTT--HHHHHHHH.HCCSHHHHHHH.HHTTTCHHHHHHHHHHHHCHHHHHHH-.......
#=GC seq_cons                   .......AGTLGISTtAAsTVVNlIsAhSTVsulISIV.GAlTGsGuIu.......uGIsATVhhllKKpGtAtAAhW.......
//
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