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Database: Pfam
Entry: Bclx_interact
LinkDB: Bclx_interact
Original site: Bclx_interact 
#=GF ID   Bclx_interact
#=GF AC   PF08945.8
#=GF DE   Bcl-x interacting, BH3 domain
#=GF AU   Mistry J, Sammut SJ
#=GF SE   pdb_1pq1
#=GF GA   25.00 25.00;
#=GF TC   27.50 27.50;
#=GF NC   24.00 24.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Bcl-x_interacting_domain
#=GF RN   [1]
#=GF RM   14499110
#=GF RT   The structure of a Bcl-xL/Bim fragment complex: implications for
#=GF RT   Bim function. 
#=GF RA   Liu X, Dai S, Zhu Y, Marrack P, Kappler JW; 
#=GF RL   Immunity. 2003;19:341-352.
#=GF RN   [2]
#=GF RM   9704409
#=GF RT   Bcl-2-family proteins: the role of the BH3 domain in apoptosis.
#=GF RA   Kelekar A, Thompson CB;
#=GF RL   Trends Cell Biol. 1998;8:324-330.
#=GF RN   [3]
#=GF RM   10816098
#=GF RT   Role of the BH3 (Bcl-2 homology 3) domain in the regulation of
#=GF RT   apoptosis and Bcl-2-related proteins.
#=GF RA   Lutz RJ;
#=GF RL   Biochem Soc Trans. 2000;28:51-56.
#=GF DR   INTERPRO; IPR015040;
#=GF CC   This domain is a long alpha helix, required for interaction with
#=GF CC   Bcl-x. It is found in BAM, Bim and Bcl2-like protein 11 [1].
#=GF CC   This domain is also known as the BH3 domain between residues 146
#=GF CC   and 161.
#=GF SQ   49
#=GS F6YSA1_CALJA/42-79        AC F6YSA1.1
#=GS B2L11_RAT/128-165         AC O88498.1
#=GS G1LDR8_AILME/128-165      AC G1LDR8.1
#=GS L5KV50_PTEAL/128-166      AC L5KV50.1
#=GS H2R0F7_PANTR/130-166      AC H2R0F7.1
#=GS E7FF06_DANRE/105-142      AC E7FF06.1
#=GS F7HHA9_MACMU/130-166      AC F7HHA9.1
#=GS F7HHA1_MACMU/70-106       AC F7HHA1.1
#=GS W5PY58_SHEEP/128-165      AC W5PY58.1
#=GS H2P5E2_PONAB/70-106       AC H2P5E2.1
#=GS A0A096NYC3_PAPAN/130-166  AC A0A096NYC3.1
#=GS G3W979_SARHA/131-168      AC G3W979.1
#=GS Q4KMV9_XENTR/128-164      AC Q4KMV9.1
#=GS M3W6B4_FELCA/128-165      AC M3W6B4.1
#=GS F7CXT2_MONDO/130-168      AC F7CXT2.1
#=GS V4AL96_LOTGI/255-299      AC V4AL96.1
#=GS H0UZH8_CAVPO/128-164      AC H0UZH8.1
#=GS G3SU55_LOXAF/131-168      AC G3SU55.1
#=GS B2L11_MOUSE/128-165       AC O54918.1
#=GS B2L11_MOUSE/128-165       DR PDB; 1PQ1 B; 83-109;
#=GS A0A091DA59_FUKDA/42-78    AC A0A091DA59.1
#=GS Q2YDF0_BOVIN/72-109       AC Q2YDF0.1
#=GS C3XZ81_BRAFL/410-450      AC C3XZ81.1
#=GS G3H020_CRIGR/72-109       AC G3H020.1
#=GS F7A7D2_HORSE/128-164      AC F7A7D2.1
#=GS G7PMY2_MACFA/130-166      AC G7PMY2.1
#=GS A0A0D9RWE0_CHLSB/70-106   AC A0A0D9RWE0.1
#=GS F7HHA7_MACMU/130-166      AC F7HHA7.1
#=GS G3R8Z8_GORGO/130-166      AC G3R8Z8.1
#=GS L5LIN7_MYODS/72-110       AC L5LIN7.1
#=GS G5BQZ0_HETGA/132-168      AC G5BQZ0.1
#=GS H0XW23_OTOGA/132-168      AC H0XW23.1
#=GS B8JK68_DANRE/105-142      AC B8JK68.1
#=GS G1QPE5_NOMLE/130-166      AC G1QPE5.1
#=GS F6XMC1_CALJA/132-169      AC F6XMC1.1
#=GS F6XLL7_CALJA/132-168      AC F6XLL7.1
#=GS M3YDI3_MUSPF/164-201      AC M3YDI3.1
#=GS C1KGB6_PIG/128-165        AC C1KGB6.1
#=GS G1MV54_MELGA/6-44         AC G1MV54.1
#=GS J9NWV6_CANLF/128-165      AC J9NWV6.1
#=GS G1SSY0_RABIT/126-163      AC G1SSY0.1
#=GS C1KGB7_PIG/72-109         AC C1KGB7.1
#=GS F7FTC8_ORNAN/75-113       AC F7FTC8.2
#=GS F6XLH3_CALJA/132-169      AC F6XLH3.1
#=GS F6Y9Z6_CALJA/72-109       AC F6Y9Z6.1
#=GS G1PDJ5_MYOLU/1-38         AC G1PDJ5.1
#=GS B2L11_HUMAN/130-166       AC O43521.1
#=GS B2L11_HUMAN/130-166       DR PDB; 4ZIH B; 144-159;
#=GS B2L11_HUMAN/130-166       DR PDB; 3KJ1 B; 1-21;
#=GS B2L11_HUMAN/130-166       DR PDB; 4A1W P; 207-223;
#=GS B2L11_HUMAN/130-166       DR PDB; 4YJ4 B; 146-163;
#=GS B2L11_HUMAN/130-166       DR PDB; 2YQ6 B; 147-164;
#=GS B2L11_HUMAN/130-166       DR PDB; 5AGX C; 1-21;
#=GS B2L11_HUMAN/130-166       DR PDB; 2WH6 B; 51-72;
#=GS B2L11_HUMAN/130-166       DR PDB; 2V6Q B; 51-73;
#=GS B2L11_HUMAN/130-166       DR PDB; 5AGW C; 1-19;
#=GS B2L11_HUMAN/130-166       DR PDB; 3IO8 D; 53-71;
#=GS B2L11_HUMAN/130-166       DR PDB; 2YQ7 B; 147-164;
#=GS B2L11_HUMAN/130-166       DR PDB; 3KJ2 B; 1-21;
#=GS B2L11_HUMAN/130-166       DR PDB; 4A1W R; 207-223;
#=GS B2L11_HUMAN/130-166       DR PDB; 2NL9 B; 53-75;
#=GS B2L11_HUMAN/130-166       DR PDB; 3KJ0 B; 1-23;
#=GS B2L11_HUMAN/130-166       DR PDB; 5AGX D; 1-21;
#=GS B2L11_HUMAN/130-166       DR PDB; 3FDL B; 84-108;
#=GS B2L11_HUMAN/130-166       DR PDB; 2K7W B; 145-164;
#=GS B2L11_HUMAN/130-166       DR PDB; 3D7V B; 53-75;
#=GS B2L11_HUMAN/130-166       DR PDB; 4A1W Q; 206-223;
#=GS B2L11_HUMAN/130-166       DR PDB; 2VM6 B; 141-165;
#=GS B2L11_HUMAN/130-166       DR PDB; 4D2M D; 53-73;
#=GS B2L11_HUMAN/130-166       DR PDB; 4ZIE C; 143-164;
#=GS B2L11_HUMAN/130-166       DR PDB; 4QVF B; 54-74;
#=GS B2L11_HUMAN/130-166       DR PDB; 4ZIF B; 144-159;
#=GS B2L11_HUMAN/130-166       DR PDB; 5AGW D; 1-21;
#=GS B2L11_HUMAN/130-166       DR PDB; 4UF3 B; 56-73;
#=GS B2L11_HUMAN/130-166       DR PDB; 4D2M B; 53-74;
#=GS B2L11_HUMAN/130-166       DR PDB; 4B4S B; 53-76;
#=GS B2L11_HUMAN/130-166       DR PDB; 3IO9 B; 53-75;
#=GS B2L11_HUMAN/130-166       DR PDB; 3IO8 B; 54-76;
#=GS B2L11_HUMAN/130-166       DR PDB; 4A1W S; 206-223;
#=GS F7HHB1_MACMU/130-167      AC F7HHB1.1
#=GS I3NFA5_ICTTR/128-165      AC I3NFA5.1
#=GS R4G9R5_ANOCA/50-88        AC R4G9R5.1
F6YSA1_CALJA/42-79                   ............ASMRQSQAEPAG.MRPEIWIAQELRRIGDEFNAYYP-R..R-l.....
B2L11_RAT/128-165                    ............ASIRQSQEEPED.LRPEIRIAQELRRIGDEFNETYT-R..R-a.....
G1LDR8_AILME/128-165                 ............ASMRQSQAVPAD.MRPEIWIAQELRRIGDEFNAYYP-R..R-v.....
L5KV50_PTEAL/128-166                 ............ASLRQSQALPAD.LRPETWIAQELRRIGDEFNASYP-R..R-vr....
H2R0F7_PANTR/130-166                 .......amasm-----RQAEPAD.MRPEIWIAQELRRIGDEFNAYYA--..RR......
E7FF06_DANRE/105-142                 ............SHQHLQMAAPVAaLPPEMVVARELRRIGDEFNRLYC--..--el....
F7HHA9_MACMU/130-166                 .........ama---SRRQAEPAD.MRPEIRIAQELRRIGDEFNAYYA--..RR......
F7HHA1_MACMU/70-106                  .........ama---SRRQAEPAD.MRPEIRIAQELRRIGDEFNAYYA--..RR......
W5PY58_SHEEP/128-165                 ............ASMRQSQAVPAD.TRPEIWIAQELRRIGDEFNAYYP-R..R-v.....
H2P5E2_PONAB/70-106                  .......amasm-----RQAEPAD.MRPEIWIAQELRRIGDEFNAYYA--..RR......
A0A096NYC3_PAPAN/130-166             .........ama---SRRQAEPAD.MRPEIRIAQELRRIGDEFNAYYA--..RR......
G3W979_SARHA/131-168                 ............ASMRQSQSIPAD.MRPEIWIAQELRRIGDEFNASYP-R..RG......
Q4KMV9_XENTR/128-164                 .......amadr--------NPVNqMSPELWIAQELRRIGDDFNASFSPR..RG......
M3W6B4_FELCA/128-165                 ............ASMRQPQAVPAD.MRPEIWIAQELRRIGDEFNAYYP-R..R-v.....
F7CXT2_MONDO/130-168                 ............ASMRQSQSIPAD.MRPEIWIAQELRRIGDEFNASYYPR..RG......
V4AL96_LOTGI/255-299                 vrdrsvslpdmq---------ALR.VQRELEVGRELRRLSDEFNTSYS-R..--grerrr
H0UZH8_CAVPO/128-164                 ............ASMRQSQAGPPH.LRPEIWIAQELRRIGDEFNASYP--..RR......
G3SU55_LOXAF/131-168                 ............ASMRQSQALPAD.LRPEIWIARELRRIGDEFNAYYP-R..R-a.....
B2L11_MOUSE/128-165                  ............ASIRQSQEEPED.LRPEIRIAQELRRIGDEFNETYT--..RRv.....
#=GR B2L11_MOUSE/128-165       SS    ............XXXXXXXXXXX-.--HHHHHHHHHHHHHHHHHHHHH--..HHH.....
A0A091DA59_FUKDA/42-78               ............ASLRQSQAEPPD.MRPEIWIAQELRRIGDEFNASYP--..RR......
Q2YDF0_BOVIN/72-109                  ............ASMRQSQAVPAD.TRPEIWIAQELRRIGDEFNAYYP-R..R-v.....
C3XZ81_BRAFL/410-450                 ............QFRARSRSEPVR.VSPEELVARELRRISDEFDSLVFSPtqRR......
G3H020_CRIGR/72-109                  ............ASIRQSQEEPAD.IRPEIWIAQELRRIGDEFNESYR-R..R-a.....
F7A7D2_HORSE/128-164                 ............ASMRQSQAVPAD.MRPEVWIAQELRRIGDEFNASYP--..RR......
G7PMY2_MACFA/130-166                 .........ama---SRRQAEPAD.MRPEIRIAQELRRIGDEFNAYYA--..RR......
A0A0D9RWE0_CHLSB/70-106              .........ama---SRRQAEPAD.MRPEIRIAQELRRIGDEFNAYYA--..RR......
F7HHA7_MACMU/130-166                 .........ama---SRRQAEPAD.MRPEIRIAQELRRIGDEFNAYYA--..RR......
G3R8Z8_GORGO/130-166                 .......amasm-----RQAEPAD.MRPEIWIAQELRRIGDEFNAYYA--..RR......
L5LIN7_MYODS/72-110                  ............ASMRQSQALPAD.MRPEMWIAQELRRIGDEFNNSYRNP..RR......
G5BQZ0_HETGA/132-168                 ............ASMRQSQAEPPD.MRPEIWIAQELRRIGDEFNASYP--..RR......
H0XW23_OTOGA/132-168                 ............ASMRQSQAEPAD.LRPEMWIAQELRRIGDEFNAYYP--..--tr....
B8JK68_DANRE/105-142                 ............SHQHLQMAAPVAaLPPEMVVARELRRIGDEFNRLYC--..--ea....
G1QPE5_NOMLE/130-166                 .......amasm-----RQAEPAD.MRPEIWIAQELRRIGDEFNAYYA--..RR......
F6XMC1_CALJA/132-169                 ............ASMRQSQAEPAG.MRPEIWIAQELRRIGDEFNAYYP-R..R-v.....
F6XLL7_CALJA/132-168                 ............ASMRQSQAEPAG.MRPEIWIAQELRRIGDEFNAYYP-R..R-......
M3YDI3_MUSPF/164-201                 ............ASRRQSQAVPAD.MRPEMWIAQELRRIGDEFNAYYP-R..R-v.....
C1KGB6_PIG/128-165                   ............ASMRQSQAEPAD.MRPEIWIAQELRRIGDEFNAYYP-R..R-v.....
G1MV54_MELGA/6-44                    ............ASRWRSHSLAEE.IQPEIWIAQELRRIGDEFNASYCPR..RG......
J9NWV6_CANLF/128-165                 ............ASMRQSQAVPAD.MRPEIWIAQELRRIGDEFNAYYP-R..R-v.....
G1SSY0_RABIT/126-163                 ............ASMRQSQAEPAD.TRPETWIAQELRRIGDEFNAYYP-R..R-v.....
C1KGB7_PIG/72-109                    ............ASMRQSQAEPAD.MRPEIWIAQELRRIGDEFNAYYP-R..R-v.....
F7FTC8_ORNAN/75-113                  ............ASIRQPQSVPED.MRPEIWIAQELRRIGDEFNASYCPR..RG......
F6XLH3_CALJA/132-169                 ............ASMRQSQAEPAG.MRPEIWIAQELRRIGDEFNAYYP-R..R-i.....
F6Y9Z6_CALJA/72-109                  ............ASMRQSQAEPAG.MRPEIWIAQELRRIGDEFNAYYP-R..R-v.....
G1PDJ5_MYOLU/1-38                    ............-SMQQSQALPVD.MRPEMWIAQELRRIGDEFNNSYRNP..RR......
B2L11_HUMAN/130-166                  .......amasm-----RQAEPAD.MRPEIWIAQELRRIGDEFNAYYA--..RR......
#=GR B2L11_HUMAN/130-166       SS    .......XXXXX-----XXXXXXX.XHHHHHHHHHHHHHHHHHHHHHH--..HX......
F7HHB1_MACMU/130-167                 .........ama---SRRQAEPAD.MRPEIRIAQELRRIGDEFNAYYA-R..R-m.....
I3NFA5_ICTTR/128-165                 ............ASMRESQAEPAD.MRPEIWIAQELRRIGDEFN-LYYPR..R-v.....
R4G9R5_ANOCA/50-88                   ...........t-SRWQSRPIPED.MQPEIWIAQELRRIGDEFNASHCPR..RG......
#=GC SS_cons                         .......XXXXX-----XXXXXXX.XHHHHHHHHHHHHHHHHHHHHHH--..HHH.....
#=GC seq_cons                        ............ASh+QSQAtPAD.MRPEIWIAQELRRIGDEFNAhYs....R.......
//
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