GenomeNet

Database: Pfam
Entry: Bclx_interact
LinkDB: Bclx_interact
Original site: Bclx_interact 
#=GF ID   Bclx_interact
#=GF AC   PF08945.5
#=GF DE   Bcl-x interacting, BH3 domain
#=GF AU   Mistry J, Sammut SJ
#=GF SE   pdb_1pq1
#=GF GA   25.00 25.00;
#=GF TC   62.30 62.20;
#=GF NC   21.80 20.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Bcl-x_interacting_domain
#=GF RN   [1]
#=GF RM   14499110
#=GF RT   The structure of a Bcl-xL/Bim fragment complex: implications for
#=GF RT   Bim function. 
#=GF RA   Liu X, Dai S, Zhu Y, Marrack P, Kappler JW; 
#=GF RL   Immunity. 2003;19:341-352.
#=GF RN   [2]
#=GF RM   9704409
#=GF RT   Bcl-2-family proteins: the role of the BH3 domain in apoptosis.
#=GF RA   Kelekar A, Thompson CB;
#=GF RL   Trends Cell Biol. 1998;8:324-330.
#=GF RN   [3]
#=GF RM   10816098
#=GF RT   Role of the BH3 (Bcl-2 homology 3) domain in the regulation of
#=GF RT   apoptosis and Bcl-2-related proteins.
#=GF RA   Lutz RJ;
#=GF RL   Biochem Soc Trans. 2000;28:51-56.
#=GF DR   INTERPRO; IPR015040;
#=GF CC   This domain is a long alpha helix, required for interaction with
#=GF CC   Bcl-x. It is found in BAM, Bim and Bcl2-like protein 11 [1].
#=GF CC   This domain is also known as the BH3 domain between residues 146
#=GF CC   and 161.
#=GF SQ   51
#=GS G7NAW7_MACMU/130-167  AC G7NAW7.1
#=GS G3R8Z8_GORGO/131-167  AC G3R8Z8.1
#=GS H0UZH8_CAVPO/127-165  AC H0UZH8.1
#=GS Q2YDF0_BOVIN/71-109   AC Q2YDF0.1
#=GS F6Y9Z6_CALJA/71-109   AC F6Y9Z6.1
#=GS F6XLH3_CALJA/131-169  AC F6XLH3.1
#=GS F7A7D2_HORSE/127-165  AC F7A7D2.1
#=GS H0XW23_OTOGA/131-169  AC H0XW23.1
#=GS C1KGB8_PIG/41-79      AC C1KGB8.1
#=GS C1KGB7_PIG/71-109     AC C1KGB7.1
#=GS D2I3R7_AILME/127-165  AC D2I3R7.1
#=GS E2IV78_LEMCA/63-101   AC E2IV78.1
#=GS Q8WXB2_HUMAN/1-34     AC Q8WXB2.1
#=GS Q3U7X3_MOUSE/41-79    AC Q3U7X3.1
#=GS G1PDJ5_MYOLU/1-39     AC G1PDJ5.1
#=GS F6XMC1_CALJA/131-169  AC F6XMC1.1
#=GS F6YSA1_CALJA/41-79    AC F6YSA1.1
#=GS E2RLS5_CANFA/127-165  AC E2RLS5.1
#=GS H2P5E2_PONAB/71-107   AC H2P5E2.1
#=GS G1LDR8_AILME/127-165  AC G1LDR8.1
#=GS E7FF06_DANRE/104-143  AC E7FF06.1
#=GS G7PMY2_MACFA/130-167  AC G7PMY2.1
#=GS F7HHA1_MACMU/70-107   AC F7HHA1.1
#=GS G1MV54_MELGA/5-44     AC G1MV54.1
#=GS F7CXT2_MONDO/129-168  AC F7CXT2.1
#=GS G3H020_CRIGR/71-109   AC G3H020.1
#=GS B2L11_RAT/127-165     AC O88498.1
#=GS G3SU55_LOXAF/130-168  AC G3SU55.1
#=GS F7HHA9_MACMU/130-167  AC F7HHA9.1
#=GS B2KKY9_DANRE/104-142  AC B2KKY9.1
#=GS E2IV80_BOVIN/115-153  AC E2IV80.1
#=GS G1SSY0_RABIT/125-163  AC G1SSY0.1
#=GS Q542N5_MOUSE/127-165  AC Q542N5.1
#=GS G3W979_SARHA/130-168  AC G3W979.1
#=GS B2L11_HUMAN/131-167   AC O43521.1
#=GS B2L11_HUMAN/131-167   DR PDB; 2NL9 B; 53-75;
#=GS B2L11_HUMAN/131-167   DR PDB; 2V6Q B; 51-73;
#=GS B2L11_HUMAN/131-167   DR PDB; 3KJ0 B; 1-23;
#=GS B2L11_HUMAN/131-167   DR PDB; 3KJ1 B; 1-21;
#=GS B2L11_HUMAN/131-167   DR PDB; 3FDL B; 84-108;
#=GS B2L11_HUMAN/131-167   DR PDB; 3D7V B; 53-75;
#=GS B2L11_HUMAN/131-167   DR PDB; 3IO8 D; 53-71;
#=GS B2L11_HUMAN/131-167   DR PDB; 2K7W B; 145-164;
#=GS B2L11_HUMAN/131-167   DR PDB; 2VM6 B; 141-165;
#=GS B2L11_HUMAN/131-167   DR PDB; 3IO9 B; 53-75;
#=GS B2L11_HUMAN/131-167   DR PDB; 3KJ2 B; 1-21;
#=GS B2L11_HUMAN/131-167   DR PDB; 2WH6 B; 51-72;
#=GS B2L11_HUMAN/131-167   DR PDB; 3IO8 B; 54-76;
#=GS B8JK68_DANRE/104-142  AC B8JK68.1
#=GS F7HHA7_MACMU/130-167  AC F7HHA7.1
#=GS G5BQZ0_HETGA/131-169  AC G5BQZ0.1
#=GS C1KGB6_PIG/127-165    AC C1KGB6.1
#=GS B2L11_MOUSE/127-165   AC O54918.1
#=GS B2L11_MOUSE/127-165   DR PDB; 1PQ1 B; 83-109;
#=GS Q4KMV9_XENTR/126-164  AC Q4KMV9.1
#=GS F1SU81_PIG/127-165    AC F1SU81.1
#=GS H2R0F7_PANTR/131-167  AC H2R0F7.1
#=GS G1QPE5_NOMLE/131-167  AC G1QPE5.1
#=GS F7FTC8_ORNAN/128-167  AC F7FTC8.1
#=GS E2IV79_SHEEP/118-156  AC E2IV79.1
#=GS Q6JTU4_HUMAN/1-34     AC Q6JTU4.1
#=GS F7HHB1_MACMU/130-167  AC F7HHB1.1
#=GS C3XZ81_BRAFL/409-450  AC C3XZ81.1
#=GS Q3KPZ6_XENLA/126-164  AC Q3KPZ6.1
#=GS F6XLL7_CALJA/131-169  AC F6XLL7.1
G7NAW7_MACMU/130-167             .....aMASRRQ--AEPAD.MRPEIRIAQELRRIGDEFNA-Y.YA.RR-v..
G3R8Z8_GORGO/131-167             ......MASMRQ--AEPAD.MRPEIWIAQELRRIGDEFNA-Y.YA.RR-v..
H0UZH8_CAVPO/127-165             ......MASMRQSQAGPPH.LRPEIWIAQELRRIGDEFNASY.-P.RRV...
Q2YDF0_BOVIN/71-109              ......MASMRQSQAVPAD.TRPEIWIAQELRRIGDEFNA-Y.YP.RRV...
F6Y9Z6_CALJA/71-109              ......MASMRQSQAEPAG.MRPEIWIAQELRRIGDEFNA-Y.YP.RRV...
F6XLH3_CALJA/131-169             ......MASMRQSQAEPAG.MRPEIWIAQELRRIGDEFNA-Y.YP.RR-i..
F7A7D2_HORSE/127-165             ......MASMRQSQAVPAD.MRPEVWIAQELRRIGDEFNASY.-P.RRV...
H0XW23_OTOGA/131-169             ......MASMRQSQAEPAD.LRPEMWIAQELRRIGDEFNA-Y.YP.TR-v..
C1KGB8_PIG/41-79                 .....q-ASMRQSQAEPAD.MRPEIWIAQELRRIGDEFNA-Y.YP.RRV...
C1KGB7_PIG/71-109                ......MASMRQSQAEPAD.MRPEIWIAQELRRIGDEFNA-Y.YP.RRV...
D2I3R7_AILME/127-165             ......MASMRQSQAVPAD.MRPEIWIAQELRRIGDEFNA-Y.YP.RRV...
E2IV78_LEMCA/63-101              ......MASMRQFQAEPAD.MRPEIWIAQELRRIGDEFNA-Y.YP.RRV...
Q8WXB2_HUMAN/1-34                ....mr-------QAEPAD.MRPEIWIAQELRRIGDEFNA-Y.YA.RR-v..
Q3U7X3_MOUSE/41-79               .....q-ASIRQSQEEPED.LRPEIRIAQELRRIGDEFNETY.TR.R--v..
G1PDJ5_MYOLU/1-39                ......--SMQQSQALPVD.MRPEMWIAQELRRIGDEFNNSYrNP.RR-d..
F6XMC1_CALJA/131-169             ......MASMRQSQAEPAG.MRPEIWIAQELRRIGDEFNA-Y.YP.RRV...
F6YSA1_CALJA/41-79               .....q-ASMRQSQAEPAG.MRPEIWIAQELRRIGDEFNA-Y.YP.RR-l..
E2RLS5_CANFA/127-165             ......MASMRQSQAVPAD.MRPEIWIAQELRRIGDEFNA-Y.YP.RRV...
H2P5E2_PONAB/71-107              ......MASMRQ--AEPAD.MRPEIWIAQELRRIGDEFNA-Y.YA.RR-v..
G1LDR8_AILME/127-165             ......MASMRQSQAVPAD.MRPEIWIAQELRRIGDEFNA-Y.YP.RRV...
E7FF06_DANRE/104-143             ......HSHQHLQMAAPVAaLPPEMVVARELRRIGDEFNRLY.C-.---elk
G7PMY2_MACFA/130-167             .....aMASRRQ--AEPAD.MRPEIRIAQELRRIGDEFNA-Y.YA.RR-v..
F7HHA1_MACMU/70-107              .....aMASRRQ--AEPAD.MRPEIRIAQELRRIGDEFNA-Y.YA.RR-v..
G1MV54_MELGA/5-44                .....a-ASRWRSHSLAEE.IQPEIWIAQELRRIGDEFNASY.CP.RRG...
F7CXT2_MONDO/129-168             ......MASMRQSQSIPAD.MRPEIWIAQELRRIGDEFNASY.YP.RRG...
G3H020_CRIGR/71-109              ......MASIRQSQEEPAD.IRPEIWIAQELRRIGDEFNESY.-R.RR-a..
B2L11_RAT/127-165                ......MASIRQSQEEPED.LRPEIRIAQELRRIGDEFNETY.T-.RR-a..
G3SU55_LOXAF/130-168             ......MASMRQSQALPAD.LRPEIWIARELRRIGDEFNA-Y.YP.RRA...
F7HHA9_MACMU/130-167             .....aMASRRQ--AEPAD.MRPEIRIAQELRRIGDEFNA-Y.YA.RR-l..
B2KKY9_DANRE/104-142             ......HSHQHLQMAAPVAaLPPEMVVARELRRIGDEFNRLY.C-.---ea.
E2IV80_BOVIN/115-153             ......MASMRQSQAVPAD.TRPEIWIAQELRRIGDEFNA-Y.YP.RRV...
G1SSY0_RABIT/125-163             ......MASMRQSQAEPAD.TRPETWIAQELRRIGDEFNA-Y.YP.RRV...
Q542N5_MOUSE/127-165             ......MASIRQSQEEPED.LRPEIRIAQELRRIGDEFNETY.TR.R--v..
G3W979_SARHA/130-168             .....t-ASMRQSQSIPAD.MRPEIWIAQELRRIGDEFNASY.-P.RRG...
B2L11_HUMAN/131-167              ......MASMRQ--AEPAD.MRPEIWIAQELRRIGDEFNA-Y.YA.RR-v..
#=GR B2L11_HUMAN/131-167   SS    ......XXXXXX--XXXXX.XHHHHHHHHHHHHHHHHHHH-H.HH.H--X..
B8JK68_DANRE/104-142             ......HSHQHLQMAAPVAaLPPEMVVARELRRIGDEFNRLY.C-.---ea.
F7HHA7_MACMU/130-167             .....aMASRRQ--AEPAD.MRPEIRIAQELRRIGDEFNA-Y.YA.RR-v..
G5BQZ0_HETGA/131-169             ......MASMRQSQAEPPD.MRPEIWIAQELRRIGDEFNASY.-P.RRV...
C1KGB6_PIG/127-165               ......MASMRQSQAEPAD.MRPEIWIAQELRRIGDEFNA-Y.YP.RRV...
B2L11_MOUSE/127-165              ......MASIRQSQEEPED.LRPEIRIAQELRRIGDEFNETY.TR.R--v..
#=GR B2L11_MOUSE/127-165   SS    ......XXXXXXXXXXXX-.--HHHHHHHHHHHHHHHHHHHH.HH.H--H..
Q4KMV9_XENTR/126-164             lsamad--------RNPVNqMSPELWIAQELRRIGDDFNASF.SP.RRG...
F1SU81_PIG/127-165               ......MASMRQSQAEPAD.MRPEIWIAQELRRIGDEFNA-Y.YP.RRV...
H2R0F7_PANTR/131-167             ......MASMRQ--AEPAD.MRPEIWIAQELRRIGDEFNA-Y.YA.RR-v..
G1QPE5_NOMLE/131-167             ......MASMRQ--AEPAD.MRPEIWIAQELRRIGDEFNA-Y.YA.RR-v..
F7FTC8_ORNAN/128-167             .....a-ASIRQPQSVPED.MRPEIWIAQELRRIGDEFNASY.CP.RRG...
E2IV79_SHEEP/118-156             ......MASMRQSQAVPAD.TRPEIWIAQELRRIGDEFNA-Y.YP.RRV...
Q6JTU4_HUMAN/1-34                ....mr-------QAEPAD.MRPEIWIAQELRRIGDEFNA-Y.YA.RR-l..
F7HHB1_MACMU/130-167             .....aMASRRQ--AEPAD.MRPEIRIAQELRRIGDEFNA-Y.YA.RR-m..
C3XZ81_BRAFL/409-450             ......LQFRARSRSEPVR.VSPEELVARELRRISDEFDSLVfSPtQRR...
Q3KPZ6_XENLA/126-164             lsamaa--------RNPVDqMTPELWIAQELRRIGDEFNASF.TP.RRA...
F6XLL7_CALJA/131-169             ......MASMRQSQAEPAG.MRPEIWIAQELRRIGDEFNA-Y.YP.RR-l..
#=GC SS_cons                     ......XXXXXXXXXXXX-.-HHHHHHHHHHHHHHHHHHHHH.HH.H--H..
#=GC seq_cons                    ......MAShRQSQAEPAD.MRPEIWIAQELRRIGDEFNA.Y.Ys.RR....
//
DBGET integrated database retrieval system