GenomeNet

Database: Pfam
Entry: CBP
LinkDB: CBP
Original site: CBP 
#=GF ID   CBP
#=GF AC   PF12192.6
#=GF DE   Fungal calcium binding protein
#=GF AU   Mistry J, Gavin OL
#=GF SE   pdb_2jv7
#=GF GA   25.00 25.00;
#=GF TC   26.40 25.90;
#=GF NC   24.90 24.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   19298372
#=GF RT   NMR structure of a fungal virulence factor reveals structural
#=GF RT   homology with mammalian saposin B.
#=GF RA   Beck MR, Dekoster GT, Cistola DP, Goldman WE;
#=GF RL   Mol Microbiol. 2009;72:344-353.
#=GF DR   INTERPRO; IPR022013;
#=GF CC   This domain is found in eukaryotes, and is approximately 60
#=GF CC   amino acids in length. There is a single completely conserved
#=GF CC   residue C that may be functionally important. This is a calcium
#=GF CC   binding domain from the fungal protein CBP (calcium binding
#=GF CC   protein). This protein is a virulence factor with unknown
#=GF CC   virulence mechanisms. CBP complexes as a highly intertwined
#=GF CC   homodimer. Each monomer is comprised of four alpha helices which
#=GF CC   adopt the saposin fold, characteristic of a protein family that
#=GF CC   binds to membranes and lipids.
#=GF SQ   29
#=GS T0KI11_COLGC/40-111      AC T0KI11.1
#=GS D8QCK3_SCHCM/10-91       AC D8QCK3.1
#=GS A6R5I8_AJECN/33-69       AC A6R5I8.1
#=GS M2R218_COCSN/80-140      AC M2R218.1
#=GS C1G5E4_PARBD/30-122      AC C1G5E4.1
#=GS A0A0A1SRZ2_9HYPO/27-99   AC A0A0A1SRZ2.1
#=GS A0A0A1TBN2_9HYPO/14-92   AC A0A0A1TBN2.1
#=GS D8QAZ8_SCHCM/21-84       AC D8QAZ8.1
#=GS A0A0G2J401_9EURO/26-91   AC A0A0G2J401.1
#=GS A0A0G2FLN2_9PEZI/75-128  AC A0A0G2FLN2.1
#=GS Q0U782_PHANO/26-107      AC Q0U782.2
#=GS D8Q8J7_SCHCM/23-82       AC D8Q8J7.1
#=GS B8NW99_ASPFN/24-99       AC B8NW99.1
#=GS F0UVX7_AJEC8/33-108      AC F0UVX7.1
#=GS A0A0L1J0F9_ASPNO/24-98   AC A0A0L1J0F9.1
#=GS A0A0L1JD36_ASPNO/16-91   AC A0A0L1JD36.1
#=GS D8QCK5_SCHCM/44-110      AC D8QCK5.1
#=GS A0A0F0IJY9_ASPPA/24-98   AC A0A0F0IJY9.1
#=GS B8NE81_ASPFN/16-91       AC B8NE81.1
#=GS D8QCK1_SCHCM/36-94       AC D8QCK1.1
#=GS A0A086SVY8_ACRCH/24-98   AC A0A086SVY8.1
#=GS A0A0D9N673_ASPFL/17-91   AC A0A0D9N673.1
#=GS C6H3B8_AJECH/33-108      AC C6H3B8.1
#=GS C1H229_PARBA/30-122      AC C1H229.2
#=GS A0A010SF34_9PEZI/42-112  AC A0A010SF34.1
#=GS A0A086T102_ACRCH/22-98   AC A0A086T102.1
#=GS CBP1_AJECG/33-108        AC O42720.1
#=GS CBP1_AJECG/33-108        DR PDB; 2JV7 A; 1-76;
#=GS CBP1_AJECG/33-108        DR PDB; 2JV7 B; 1-76;
#=GS A0A0F0IAB9_ASPPA/17-93   AC A0A0F0IAB9.1
#=GS Q2TWZ3_ASPOR/24-95       AC Q2TWZ3.1
T0KI11_COLGC/40-111                 ...cetsndlgacnnai-----------------TKLRGHEARGCDVWSCIGAFATVIPTCAAA..VDELFLNPVADLACLGA..............VA----N--------fqgpckdc.
D8QCK3_SCHCM/10-91                  ........alaavasaa------PAADIISSEVVAGNQLADHISCPILDCAKSLASNVSSCGKA..VASLGRNVIADAQCLAA..............AVSTIANAPDSCKQC.........
A6R5I8_AJECN/33-69                  .................DQPSLDEAFNMYNEAVNVFMKVSSAADCDWP----------------..-----------------..............---------------vsahfl...
M2R218_COCSN/80-140                 ..qvgrcrnaiadlrrr-----------------------ELRGCDVFACISAGVSSAASCAAAaaAAEGGLNKILS------..............---------------sslkiqint
C1G5E4_PARBD/30-122                 ................a-QPAVKHALGQFNQAVTMFEKATAAASCNWITCLESLAASSAACAAA..LGELGLGMSFPMQRTITspltspvllllpqpAPRAARDASKSARGP.........
A0A0A1SRZ2_9HYPO/27-99              .............rqdr--------LELFKNEAQIIHTDAAQAGCDWGKCITALAGETAACGAA..AVELGANIFADIACIAS..............VGGAINNAA------canc.....
A0A0A1TBN2_9HYPO/14-92              avsaadnaipagrvaim-------------KSAAEYNAQAAIAGCDWVNCISSLAGATAACAAA..FAQGAANPVLDLACLAS..............----VGSTGPACRGC.........
D8QAZ8_SCHCM/21-84                  .......apvaeirtaq-------------------------IKCPIVECLAALAPTVAICGVA..AAQGGADVPNDVVCLAS..............AANSAVNFPDSCNQ-c........
A0A0G2J401_9EURO/26-91              ................r-ATQVASAFADYKNAVNSIQALTASNGCNWVECIQSLSISSGSCIAA..LAELGLEWPL-------..............---------------cghaqiqal
A0A0G2FLN2_9PEZI/75-128             ..............wcw----------------------------DFYKCIAALAPTVVACSTA..LASLGLNPVADANCAAA..............AANNGINLPHACDGC.........
Q0U782_PHANO/26-107                 .........stsmvvrd-----TSAVSALQAQAETFLAAKEAAGCSKLKCIAALAPTAAACAAA..LAEAGLNPLADAACLAT..............LANSVFNVPEPCKGC.........
D8Q8J7_SCHCM/23-82                  ...........vqreaq-------------------------LSCPIVECLAALAPAAAICGVA..AATLGRDTAADVNCLAN..............AANAGVNFPDSCQQC.........
B8NW99_ASPFN/24-99                  ................s-ATNIQSAAD-INNIASAWTKAKEDDGCSWLACISSVVGQSATCAAA..AAELALNPIADVACVAG..............LGTMT----------lsggpags.
F0UVX7_AJEC8/33-108                 .................DQPSVGDAFDKYNEAVKVFTQLSSAANCDWPACLSSLSASSAACIAA..IGELGLDIPLDLACAAT..............---ATTSATQACKGC.........
A0A0L1J0F9_ASPNO/24-98              ................s-ATNIQSAAD-IHNIASAWTKAKENDGCSWLACISSVVGQSATCAAA..AAELALNPIADVACVAG..............L-GTMTVACKPC---v........
A0A0L1JD36_ASPNO/16-91              .........aapastaq-------NIQDVQSNAAAFMEAKKASGCDWLACVSSLAGESAACAAA..AAELGANPIADAACIAS..............VGTSTAS--------crkc.....
D8QCK5_SCHCM/44-110                 .........asplvard--------------------QLADHISCPILDCAKGLASTVSACGKA..AISLGRNVIADAQCLAQ..............AVKTVTNVPDACKQC.........
A0A0F0IJY9_ASPPA/24-98              ................s-ATNIQSAAD-INNIASAWAKAKEDDGCSWLACISSVVGQSATCAAA..AAELALNPIADAACVAG..............L-GTMTVACKPC---v........
B8NE81_ASPFN/16-91                  ..........aapasta------QNLQDLQNNAAAFTEAKKAAGCDWLACVSSLAGESAACAAA..AAELGANPIADAACIAS..............VGTS----TASCK--kc.......
D8QCK1_SCHCM/36-94                  ..........hiscplv---------------------------CNPQSCLGSLAPSVATCGAA..LATAGANIFADISCLTA..............AVKTVTSLPDSCKQC.........
A0A086SVY8_ACRCH/24-98              ...............ra--PEVTA-LD-ISKSAELYTSQLEAQGCNVWSCVVAAAPLLPICAAA..LIEP--TPLGEIACIIA..............IVNLGTNKPAACNGC.........
A0A0D9N673_ASPFL/17-91              ...........apasta------QNLQDVQNNAAAFTEAKKAAGCDWLACVSSLAGESAACAAA..AAELGANPIADAACIAS..............VGTS----TASCK--kc.......
C6H3B8_AJECH/33-108                 .................DQPSVGDAFDKYNEAVKVFTQLSSAANCDWPACLSSLSASSAACIAA..IGELGLDIPLDLACAAT..............---ATTSATQACKGC.........
C1H229_PARBA/30-122                 .................PKPAVTHALNEFKHAVTTFEKATSAASCDWITCLESLAASSAACAAA..LEELGLSMPFPMQRTITspltlpvllllpqpAPKAARDASKSALGP.........
A0A010SF34_9PEZI/42-112             ..etsnnlgacnnaiar-------------------LRGHEARGCDVWSCIGAFAAVIPACGAA..VDELFLNPLADVACLGA..............----VANFQGPCKGC.........
A0A086T102_ACRCH/22-98              .........dkrapels-------ATD-IAKSAELYTSELEAQGCDLWGCIVAAAPLLPVCAAA..LIEP--TPLGEIACIIA..............VVNLGTNKPAPCQGC.........
CBP1_AJECG/33-108                   .................DQPSVGDAFDKYNEAVRVFTQLSSAANCDWAACLSSLSASSAACIAA..VGELGLDVPLDLACAAT..............---ATSSATEACKGC.........
#=GR CBP1_AJECG/33-108        SS    .................--SSHHHHHHHHHHHHHHHHHHHHHHT----HHHHHHTT--HHHHHH..HHSSSSTTTTHHHHHHT..............---SSS---TTT-SS.........
A0A0F0IAB9_ASPPA/17-93              ...........apasta------QNLQDLQNNAAAFTEAKKAAGCDWLACVSSLAGESAACAAA..AAELGANPFADAACIAS..............VGTSTVEVD------kell.....
Q2TWZ3_ASPOR/24-95                  ................s-ATNIQSAAD-INNIASAWTKAKEDDGCSWLACISSVVGQSATCAAA..AAELALNPIADVACVAG..............------LGTMTCFGN.........
#=GC SS_cons                        .................--SSHHHHHHHHHHHHHHHHHHHHHHT----HHHHHHTT--HHHHHH..HHSSSSTTTTHHHHHHT..............---SSS---TTT-SS.........
#=GC seq_cons                       ................t.......shp.hpp.sthatphppssuCsahsCluuLAupsAuCuAA..huELGhNshuDhAClAu..............hstsshshstsC............
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