GenomeNet

Database: Pfam
Entry: CBP
LinkDB: CBP
Original site: CBP 
#=GF ID   CBP
#=GF AC   PF12192.5
#=GF DE   Fungal calcium binding protein
#=GF AU   Mistry J, Gavin OL
#=GF SE   pdb_2jv7
#=GF GA   25.00 25.00;
#=GF TC   26.90 25.90;
#=GF NC   23.90 23.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   19298372
#=GF RT   NMR structure of a fungal virulence factor reveals structural
#=GF RT   homology with mammalian saposin B.
#=GF RA   Beck MR, Dekoster GT, Cistola DP, Goldman WE;
#=GF RL   Mol Microbiol. 2009;72:344-353.
#=GF DR   INTERPRO; IPR022013;
#=GF CC   This domain is found in eukaryotes, and is approximately 60
#=GF CC   amino acids in length. There is a single completely conserved
#=GF CC   residue C that may be functionally important. This is a calcium
#=GF CC   binding domain from the fungal protein CBP (calcium binding
#=GF CC   protein). This protein is a virulence factor with unknown
#=GF CC   virulence mechanisms. CBP complexes as a highly intertwined
#=GF CC   homodimer. Each monomer is comprised of four alpha helices which
#=GF CC   adopt the saposin fold, characteristic of a protein family that
#=GF CC   binds to membranes and lipids.
#=GF SQ   17
#=GS T0KI11_COLGC/40-111  AC T0KI11.1
#=GS D8QCK3_SCHCM/10-91   AC D8QCK3.1
#=GS A6R5I8_AJECN/33-69   AC A6R5I8.1
#=GS M2R218_COCSN/80-140  AC M2R218.1
#=GS C1G5E4_PARBD/30-122  AC C1G5E4.1
#=GS D8QAZ8_SCHCM/21-84   AC D8QAZ8.1
#=GS Q0U782_PHANO/26-107  AC Q0U782.2
#=GS B8NW99_ASPFN/24-99   AC B8NW99.1
#=GS D8Q8J7_SCHCM/23-82   AC D8Q8J7.1
#=GS F0UVX7_AJEC8/33-108  AC F0UVX7.1
#=GS D8QCK5_SCHCM/44-110  AC D8QCK5.1
#=GS D8QCK1_SCHCM/36-94   AC D8QCK1.1
#=GS B8NE81_ASPFN/16-91   AC B8NE81.1
#=GS C6H3B8_AJECH/33-108  AC C6H3B8.1
#=GS C1H229_PARBA/30-122  AC C1H229.2
#=GS CBP1_AJECG/33-108    AC O42720.1
#=GS CBP1_AJECG/33-108    DR PDB; 2JV7 A; 1-76;
#=GS CBP1_AJECG/33-108    DR PDB; 2JV7 B; 1-76;
#=GS Q2TWZ3_ASPOR/24-95   AC Q2TWZ3.1
T0KI11_COLGC/40-111             .cetsndlgacnnai-----------------TKLRGHEARGCDVWSCIGAFATVIPTCAAA..VDELFLNPVADLACLGA..............VA----N--------fqgpckdc.
D8QCK3_SCHCM/10-91              ......alaavasaa------PAADIISSEVVAGNQLADHISCPILDCAKSLASNVSSCGKA..VASLGRNVIADAQCLAA..............AVSTIANAPDSCKQC.........
A6R5I8_AJECN/33-69              ...............DQPSLDEAFNMYNEAVNVFMKVSSAADCDWP----------------..-----------------..............---------------vsahfl...
M2R218_COCSN/80-140             qvgrcrnaiadlrrr-----------------------ELRGCDVFACISAGVSSAASCAAAaaAAEGGLNKILS------..............---------------sslkiqint
C1G5E4_PARBD/30-122             ..............a-QPAVKHALGQFNQAVTMFEKATAAASCNWITCLESLAASSAACAAA..LGELGLGMSFPMQRTITspltspvllllpqpAPRAARDASKSARGP.........
D8QAZ8_SCHCM/21-84              .....apvaeirtaq-------------------------IKCPIVECLAALAPTVAICGVA..AAQGGADVPNDVVCLAS..............AANSAVNFPDSCNQ-c........
Q0U782_PHANO/26-107             .......stsmvvrd-----TSAVSALQAQAETFLAAKEAAGCSKLKCIAALAPTAAACAAA..LAEAGLNPLADAACLAT..............LANSVFNVPEPCKGC.........
B8NW99_ASPFN/24-99              ..............s-ATNIQSAAD-INNIASAWTKAKEDDGCSWLACISSVVGQSATCAAA..AAELALNPIADVACVAG..............LGTMT----------lsggpags.
D8Q8J7_SCHCM/23-82              .........vqreaq-------------------------LSCPIVECLAALAPAAAICGVA..AATLGRDTAADVNCLAN..............AANAGVNFPDSCQQC.........
F0UVX7_AJEC8/33-108             ...............DQPSVGDAFDKYNEAVKVFTQLSSAANCDWPACLSSLSASSAACIAA..IGELGLDIPLDLACAAT..............---ATTSATQACKGC.........
D8QCK5_SCHCM/44-110             .......asplvard--------------------QLADHISCPILDCAKGLASTVSACGKA..AISLGRNVIADAQCLAQ..............AVKTVTNVPDACKQC.........
D8QCK1_SCHCM/36-94              ........hiscplv---------------------------CNPQSCLGSLAPSVATCGAA..LATAGANIFADISCLTA..............AVKTVTSLPDSCKQC.........
B8NE81_ASPFN/16-91              ........aapasta------QNLQDLQNNAAAFTEAKKAAGCDWLACVSSLAGESAACAAA..AAELGANPIADAACIAS..............VGTS----TASCK--kc.......
C6H3B8_AJECH/33-108             ...............DQPSVGDAFDKYNEAVKVFTQLSSAANCDWPACLSSLSASSAACIAA..IGELGLDIPLDLACAAT..............---ATTSATQACKGC.........
C1H229_PARBA/30-122             ...............PKPAVTHALNEFKHAVTTFEKATSAASCDWITCLESLAASSAACAAA..LEELGLSMPFPMQRTITspltlpvllllpqpAPKAARDASKSALGP.........
CBP1_AJECG/33-108               ...............DQPSVGDAFDKYNEAVRVFTQLSSAANCDWAACLSSLSASSAACIAA..VGELGLDVPLDLACAAT..............---ATSSATEACKGC.........
#=GR CBP1_AJECG/33-108    SS    ...............HHHHHHHHHHHT----HHHHHHTT--HHHHHHHHSSSSTTTTHHHHH..SSS---TTT-SSXXXXX..............---XXXXXXXXXXXX.........
Q2TWZ3_ASPOR/24-95              ..............s-ATNIQSAAD-INNIASAWTKAKEDDGCSWLACISSVVGQSATCAAA..AAELALNPIADVACVAG..............------LGTMTCFGN.........
#=GC SS_cons                    ...............HHHHHHHHHHHT----HHHHHHTT--HHHHHHHHSSSSTTTTHHHHH..SSS---TTT-SSXXXXX..............---XXXXXXXXXXXX.........
#=GC seq_cons                   ......................sht.hpt.s.sh.phppstuCshhsCluuLuusuAsCuAA..huELGhsh.hDhsChAs..............hs.ss.shspuCpts.........
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