#=GF ID   CCAP
#=GF AC   PF11105.3
#=GF DE   Arthropod cardioacceleratory peptide 2a
#=GF AU   Pollington J, Finn RD
#=GF SE   PRODOM
#=GF GA   20.20 20.20;
#=GF TC   21.20 35.90;
#=GF NC   19.70 19.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   18521612
#=GF RT   Pleiotropic effects of the neuropeptides CCAP and myosuppressin
#=GF RT   in the beetle, Tenebrio molitor L. 
#=GF RA   Wasielewski O, Skonieczna M; 
#=GF RL   J Comp Physiol [B]. 2008; [Epub ahead of print]
#=GF DR   INTERPRO; IPR024276;
#=GF CC   CCAP exerts a reversible and dose-dependant cardio-stimulatory
#=GF CC   effect on the semi-isolated heart of experimental beetles. CCAP
#=GF CC   also increases free hemolymph sugar concentration in young
#=GF CC   larvae and adults of the meal-worm beetle [1].
#=GF SQ   47
#=GS Q29QG1_DROME/1-141   AC Q29QG1.1
#=GS B4KAC6_DROMO/1-139   AC B4KAC6.1
#=GS D6WA20_TRICA/1-121   AC D6WA20.1
#=GS Q1WK20_HOMGA/10-72   AC Q1WK20.1
#=GS B4G5V3_DROPE/1-143   AC B4G5V3.1
#=GS B0XKC5_CULQU/2-152   AC B0XKC5.1
#=GS Q05K63_PROCL/10-69   AC Q05K63.1
#=GS F1AHD5_RHOPR/1-62    AC F1AHD5.1
#=GS E9HE05_DAPPU/1-104   AC E9HE05.1
#=GS B4LXC8_DROVI/1-138   AC B4LXC8.1
#=GS E3VW01_RHOPR/59-110  AC E3VW01.1
#=GS D2J4U0_RHOPR/1-62    AC D2J4U0.1
#=GS H9KMA2_APIME/1-103   AC H9KMA2.1
#=GS C4WWN1_ACYPI/13-74   AC C4WWN1.1
#=GS B4PMD9_DROYA/1-141   AC B4PMD9.1
#=GS CCAP_DROME/1-137     AC Q9VCW0.1
#=GS CCAP_DROME/1-137     DR PDB; 1Y49 A; 1-9;
#=GS E2B4A4_HARSA/2-90    AC E2B4A4.1
#=GS CCAP_PERAM/4-69      AC Q75UG5.1
#=GS B3LZU0_DROAN/1-142   AC B3LZU0.1
#=GS E0VG48_PEDHC/13-72   AC E0VG48.1
#=GS C4WWN1_ACYPI/71-122  AC C4WWN1.1
#=GS G6D6R9_DANPL/1-125   AC G6D6R9.1
#=GS Q7PM76_ANOGA/2-150   AC Q7PM76.3
#=GS B4HES2_DROSE/1-141   AC B4HES2.1
#=GS D2J4U0_RHOPR/59-110  AC D2J4U0.1
#=GS Q17NP9_AEDAE/2-144   AC Q17NP9.1
#=GS E3WZG0_ANODA/2-150   AC E3WZG0.1
#=GS B4R0P9_DROSI/1-141   AC B4R0P9.1
#=GS Q1WK19_9EUCA/9-69    AC Q1WK19.1
#=GS Q1WK21_CARMA/13-73   AC Q1WK21.1
#=GS B7Q5V5_IXOSC/4-114   AC B7Q5V5.1
#=GS H9JJA5_BOMMO/80-163  AC H9JJA5.1
#=GS CCAP_MANSE/1-125     AC Q8WRC7.1
#=GS CCAP_MANSE/1-125     DR PDB; 1V46 A; 1-9;
#=GS B4JIE3_DROGR/1-138   AC B4JIE3.1
#=GS B0WGM9_CULQU/2-152   AC B0WGM9.1
#=GS CCAP_PERAM/65-116    AC Q75UG5.1
#=GS Q05K64_PROCL/10-69   AC Q05K64.1
#=GS E3VW01_RHOPR/1-65    AC E3VW01.1
#=GS H9JJA5_BOMMO/1-80    AC H9JJA5.1
#=GS B4N9R1_DROWI/1-145   AC B4N9R1.1
#=GS Q1WK22_CALSI/9-73    AC Q1WK22.1
#=GS D5FGC7_DAPPU/2-103   AC D5FGC7.1
#=GS B3IUE1_BOMMO/1-125   AC B3IUE1.1
#=GS F1AHD5_RHOPR/59-110  AC F1AHD5.1
#=GS E0VG48_PEDHC/69-120  AC E0VG48.1
#=GS B3P8L0_DROER/1-140   AC B3P8L0.1
#=GS Q29AT4_DROPS/1-143   AC Q29AT4.2
Q29QG1_DROME/1-141              ..................................MRTSMRISLRLLALLAC....AICSQAS..LERENNEGTN..MANH.KLSGviq..wkyEKRPFCNAFTGCGRKRT-YPSYP.......PFSLFKRN..........EVEEKPYNNEy.lsEGLSDLIDINAEPAVENVQKQIMSQAKIFEAIKEASKEIFRQKNKQKMLQ..............................................
B4KAC6_DROMO/1-139              ..................................MSASVEICFYLTAILIC....MYTANAS..LETENNEVNH..KLSG.VIQWk......yEKRPFCNAFTGCGRKRTSYPSYP.......PFSLIKRN..........ELEEKPYNNNeylsEGLSDLIDINAEPAVENVQKQIMSQAKIFEAIKEASKEIFRQKNKQKML-e.............................................
D6WA20_TRICA/1-121              .....mttaklfvicifaalaiethsrflpksis-----------------....-------..------KNLG..ATER.VLEP........KKRPFCNAFTGCGRKRSNLPALP.......EQS-----..........------EVVD....ENLGSLLELSAEPAVEDLSRQIMSEAKLWEAIQEANMELHRRRQESA---ess...........................................
Q1WK20_HOMGA/10-72              ....vgilgvttvlllvllaahaqagpvakrdig-----------------....-------..----------..--DL.LEGK........DKRPFCNAFTGCGKKRSD-PS--.......--------..........----------....--------------------------------------------------meglass.......................................
B4G5V3_DROPE/1-143              ..................................MKSSLKMCLGLVVLLIC....MLSGNAS..LERENNEVNN..LANH.KLSGviq..wkyEKRPFCNAFTGCGRKRTSYPSYP.......PFSLIKRN..........ELEEKPYNNEy.lsEGLSDLIDINAEPAVENVQKQIMSQAKIFEAIKEASKEIFRQKSNRQ---kmle..........................................
B0XKC5_CULQU/2-152              .............................spttv-----TSLFALTVAMAFfihvIDCGVVD..REPRAYKQYN..TNSN.SAGGggg..evpAKRPFCNAFTGCGKKRS-SVAVT.......PVAMMHRHalts.eqnrpKVTEGFDPNE....DSLANLIDLNTEPAVEDLMRQIMSEAKLWEAIQEANREIYLQKQGQKTQ-s.............................................
Q05K63_PROCL/10-69              .agvmvlpallllvlaahahagplakrdigdlle-----------------....-------..----------..----.--GK........DKRPFCNAFTGCGKKRSD-----.......--------..........----------....--------------------------------------------------pglegva.......................................
F1AHD5_RHOPR/1-62               ............................mqllvp------CFLLFTALVSA....VLTDDVF..LQKRLYFPGE..IAEP.IDPK........MKKPFCNAFTGCGKKRSD-----.......--------..........----------....--------------------------------------------------es............................................
E9HE05_DAPPU/1-104              ..........................mtrplfys-------LLMLAWMIIS....LYISASS..SQPLKNNQND..SDSAeEIEQws....fkEKRPFCNAFAGCGRKRSMIK---.......--------..........----------....--------------------------------------------------dtkhppyekaasnhprlpnadtklldklfakiqhqr..........
B4LXC8_DROVI/1-138              ..................................MRATVEIFLGLAAIIIC....LYTANAS..LEIENNEVNH..KLSG.VIQWk......yEKRPFCNAFTGCGRKRTSYPSYP.......PFSLIKRN..........ELEEKPYNNEy.lsEGLSDLIDINAEPAVENVQKQIMSQAKIFEAIKEASKEIFRQKNKQKML-e.............................................
E3VW01_RHOPR/59-110             .................................s-----------------....-------..----------..----.----........-----------------------.......--------..........---------D....ESMATLVDLNSEPAVEELSRQILSEAKLWEAIQEARMELLNRKQQQSD--ri............................................
D2J4U0_RHOPR/1-62               .............................mqllv-----PCFLLFTALVFA....VLTDDVF..LQKRVYFPGE..IAEP.IDPK........MKKPFCNAFTGCGKKRSD-----.......--------..........----------....--------------------------------------------------es............................................
H9KMA2_APIME/1-103              ...........................mkiinyv---------------CCi..lAFVCLMN..VIRSEESQSK..MEQQ.FLDVfttdeslkMKRPFCNAFTGCGKKRNFHENPT.......--------..........----------....--------------------------------------------------dsqdleingnirlpfsiykallraatrnvneyqvsg..........
C4WWN1_ACYPI/13-74              ..........................psiltlvw----MSILVSLVQTVF-....--ADDVI..MQKRYFDNDNpvAEP-.--IR........RKKPFCNAFTGCGRKRSD-----.......--------..........----------....--------------------------------------------------es............................................
B4PMD9_DROYA/1-141              ..................................MRTSMRISLRLIALLAC....FICSQAS..LERENNEGPN..MANH.KLSGviq..wkyEKRPFCNAFTGCGRKRT-YPSYP.......PFSLFKRN..........EVEEKPYNNEy.lsEGLSDLIDINAEPAVENVQKQIMSQAKIFEAIKEASKEIFRQKNKQKMLQ..............................................
CCAP_DROME/1-137                ..................................----MRISLRLLALLAC....AICSQAS..LERENNEGTN..MANH.KLSGviq..wkyEKRPFCNAFTGCGRKRT-YPSYP.......PFSLFKRN..........EVEEKPYNNEy.lsEGLSDLIDINAEPAVENVQKQIMSQAKIFEAIKEASKEIFRQKNKQKMLQ..............................................
#=GR CCAP_DROME/1-137     SS    ..................................----XXXXXXXXXXXXX....XXXXXXX..XXXXXXXXXX..XXXX.XXXXXXX..XXXXXX--SSSSS--XXXXX-XXXXX.......XXXXXXXX..........XXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..............................................
E2B4A4_HARSA/2-90               .................asseisrdkferqllda-----------------....-------..---------L..TTER.TMK-........PKRPFCNAFTGCGRKRSFSASIP.......TL------..........----------....--------------------------------------------------rdsqdfrandnvrlpvslyralllnaakqntwdaidree.......
CCAP_PERAM/4-69                 ...........................yhvvlgc-------SLAILLVILDi.pqASCDDVV..IQKRQVDPAE..MDRL.LDPK........RKRPFCNAFTGCGKKRSDE----.......--------..........----------....--------------------------------------------------sm............................................
B3LZU0_DROAN/1-142              ..............................mtsp----IKNSLRMAVLLVF....VISCQAS..LERENSEVNN..LSNH.KLSGviq..wkyEKRPFCNAFTGCGRKRTSYPSYP.......PFSLIKRN..........EIEEKPYNNEy.lsEGLSDLIDINAEPAVENVQKQIMSQAKIFEAIKEASKEIFRQKNKQKL--le............................................
E0VG48_PEDHC/13-72              ...............sfafiylitltfvtgddvi-----------------....-------..LQKRSERNRL..DMDR.FMYDg.....haMKRPFCNAFTGCGKKRSEG----.......--------..........----------....--------------------------------------------------s.............................................
C4WWN1_ACYPI/71-122             .................................s-----------------....-------..----------..----.----........-----------------------.......--------..........---------D....ESMATLVDLRSEPAVEEISRQIMSEAKLWEAIQEARLELIRQQRQNKAE-r.............................................
G6D6R9_DANPL/1-125              ...............................mss---TSRASL-LIIALLC....LDCCYSA..TIPRPFDPRL..TEEV.ILSP........KKRPFCNAFTGCGRKRSQATPGM.......PMNEIAR-..........---QRQFVDE....DAIESL--VDSDMTIDELSRQILTEAKLWEAIQEASAEIARRKQKEM---yn............................................
Q7PM76_ANOGA/2-150              .................................t-HRTAAKLLLAVVSLFCvlqmLECGVVD..RQPRAYKQYN..TEP-.----........QKRPFCNAFTGCGKKRSSASSPPtaaaaaaAAAMLQRHlqtmdpgrkdRMGSDFDPNE....ESISSLLDLNTEPAVEDLLRQIMSEAKLWEAIQEANREIYLQKSGMKDQR..............................................
B4HES2_DROSE/1-141              ..................................MRTSMRISLRLLALLAC....AICSQAS..LERENNEGPN..MANH.KLSGviq..wkyEKRPFCNAFTGCGRKRT-YPSYP.......PFSLFKRN..........EVDEKPYNNEy.lsEGLSDLIDINAEPAVENVQKQIMSQAKIFEAIKEASKEIFRQKNKQKMLQ..............................................
D2J4U0_RHOPR/59-110             .................................s-----------------....-------..----------..----.----........-----------------------.......--------..........---------D....ESMATLVDLNSEPAVEELSRQILSEAKLWEAIQEARMELLNRKQQQSD--ri............................................
Q17NP9_AEDAE/2-144              .................................n-STAVTILLALAVTILClahvIDCGVVD..REPRAYKQYS..NEP-.--PP........AKRPFCNAFTGCGKKRSSVVPVT.......PVNMIHRHalts.eqnrpKVTEGFDPNE....DSLANLIDLNTEPAVEDLMRQIMSEAKLWEAIQEANREIYLQKQGQKSE-s.............................................
E3WZG0_ANODA/2-150              ...............................tpa---TSAKLLLTLGALFCvlqmLECGVVD..RQPRAYRQYS..SEP-.----........QKRPFCNAFTGCGKKRSTATSPPstaasaaAAAMLQRHlqnmesarkdRSGGDFDPNE....ESISSLLDLNTEPAVEDLLRQIMSEAKLWEAIQEANREIYLQKSGVNQ--hr............................................
B4R0P9_DROSI/1-141              ..................................MRTSMRISLRLLALLAC....AICSQAS..LERENNEGPN..MANH.KLSGviq..wkyEKRPFCNAFTGCGRKRT-YPSYP.......PFSLFKRN..........EVEEKPYNNEy.lsEGLSDLIDINAEPAVENVQKQIMSQAKIFEAIKEASKEIFRQKNKQKMLQ..............................................
Q1WK19_9EUCA/9-69               ragvmvltallllvlaahahagplvkrdigdlle-----------------....-------..----------..----.--GK........DKRPFCNAFTGCGKKRSD-----.......--------..........----------....--------------------------------------------------pglegva.......................................
Q1WK21_CARMA/13-73              ........wlvtagsllllvflvtnaqagpvakr-----------------....-------..----DIDSLL..DGK-.----........IKRPFCNAFTGCGKKRSD-----.......--------..........----------....--------------------------------------------------peleglas......................................
B7Q5V5_IXOSC/4-114              .........................dlstvisss----------LYILLL-....SACLSAA..LEKQ--DDT-..ADDS.YLVE........QKRPFCNAFTGCGGKRSSPN---.......RIDLLARL..........----------....--------------------------------------------------qnrllseirnlelrtrleegpsrrhdeytdnvsrlnkreesisdas
H9JJA5_BOMMO/80-163             ...........................cfkhvlf-----------------....-------..----------..----.----........--------YQGCGRKRSQTAPGM.......PNQ----D..........LMRQRQYVDE....DTLGTM--LDSESAIDELSRQILSEAKLWEAIQEASAEIARRKQKEF---yns...........................................
CCAP_MANSE/1-125                ..................................MTVSRVCLLLLVALVY-....LDCCYAA..SIPRNFDPRL..SEEI.VMAP........KKRPFCNAFTGCGRKRSQGPPGM.......PAQ-----..........DLRTKQYLDE....EALGSI--LDSESAIDELSRQILSEAKLWEAIQEASAEIARRKQKEAYIQ..............................................
#=GR CCAP_MANSE/1-125     SS    ..................................XXXXXXXXXXXXXXXX-....XXXXXXX..XXXXXXXXXX..XXXX.XXXX........XXX----SSS--XXXXXXXXXXX.......XXX-----..........XXXXXXXXXX....XXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..............................................
B4JIE3_DROGR/1-138              ..................................MRTTLEIFLCLAAIFLF....AYSADAS..LETENNEVNH..KLS-.---Gviq..wkfEKRPFCNAFTGCGRKRTSYPSYP.......PFSLFKRN..........EIEEKPYNNEy.lsEGLSDLIDINAEPAVENVQKQIMSQAKIFEAIKEASKEIFRQKNKQKL--le............................................
B0WGM9_CULQU/2-152              .............................spttv-----TSLFALTVAMAFfihvIDCGVVD..REPRAYKQYN..TNSN.TAGGggg..evpAKRPFCNAFTGCGKKRS-SVAVT.......PVAMMHRHalts.eqnrpKVTEGFDPNE....DSLANLIDLNTEPAVEDLMRQIMSEAKLWEAIQEANREIYLQKQGQKTQ-s.............................................
CCAP_PERAM/65-116               .................................s-----------------....-------..----------..----.----........-----------------------.......--------..........---------D....ESMGTLVEMNSEPAVDDLSRQILSEVKLWEAIQEARVELLRRRQEQLQQQ..............................................
Q05K64_PROCL/10-69              .agvmvlpallllvlaahahagplakrdigdlle-----------------....-------..----------..----.--GK........DKRPFCNAFTGCGKKRSD-----.......--------..........----------....--------------------------------------------------pglegva.......................................
E3VW01_RHOPR/1-65               ............................mqllvp------CFLLFTALVSA....VLTDDVF..LQKRVYFPGE..IAEP.IDPK........MKKPFCNAFTGCGKKRSDES---.......--------..........----------....--------------------------------------------------mat...........................................
H9JJA5_BOMMO/1-80               .................................m---TSRVLLVLVVALLC....AECCVTA..TIPRNFDPRS..NEEM.VTMP........KKRPFCNAFTAVTVTRYSQSFS-.......--------..........----------....--------------------------------------------------knylsirrlraltkpikc............................
B4N9R1_DROWI/1-145              .................................m-NISTKLCLWLALLLFS....VLCGSASleRERQTNEVNN..LSNH.KLSGviq..wkyEKRPFCNAFTGCGRKRTSYPSYP.......PFSLIKRN..........DIDDKPYNNEy.msEGLSDLIDINAEPAVENVQKQIMSQAKIFEAIKEASKEIFRQKNKQKL--les...........................................
Q1WK22_CALSI/9-73               .....sgraglmtawtilllaflianteagivak-----------------....-------..--------RD..IDS-.VLDG.......kIKRPFCNAFTGCGKKRSD-----.......--------..........----------....--------------------------------------------------peleglas......................................
D5FGC7_DAPPU/2-103              ............................rplfys-------LLMLAWMIIS....LYISASS..SQPLKNNQND..SDSAeEIEQws....fkEKRPFCNAFAGCGRKRSMIKD--.......--------..........----------....--------------------------------------------------tkhppyekaasnhlrlpnadtklldklfakiqhqr...........
B3IUE1_BOMMO/1-125              .................................m---TSRVLLVLVVALLC....AECCVTA..TIPRNFDPRS..NEEM.VTMP........KKRPFCNAFTGCGRKRSQTAPGM.......PNQ----D..........LMRQRQYVDE....DTLGTM--LDSESAIDELSRQILSEAKLWEAIQEASAEIARRKQKEF---yns...........................................
F1AHD5_RHOPR/59-110             .................................s-----------------....-------..----------..----.----........-----------------------.......--------..........---------D....ESMATLVDLNSEPAVEELSRQILSEAKLWEAIQEARMELLNRKQQQSD--ri............................................
E0VG48_PEDHC/69-120             .................................s-----------------....-------..----------..----.----........-----------------------.......--------..........---------E....GSIGNILGFNTEPESDELLKQFLTEAKLWETIQEAKMELERRRQGRQ---nav...........................................
B3P8L0_DROER/1-140              ..................................MRTFMRISLRLVALLVC....FICSQAS..LEREN-EGPN..MANH.KLSGviq..wkyEKRPFCNAFTGCGRKRT-YPSYP.......PFSLFKRN..........EIEEKPYNNEy.lsEGLSDLIDINAEPAVENVQKQIMSQAKIFEAIKEASKEIFRQKNKQKMLQ..............................................
Q29AT4_DROPS/1-143              ..................................MKSSLKMCLGLVVLLIC....MLSGNAS..LERENNEVNN..LANH.KLSGviq..wkyEKRPFCNAFTGCGRKRTSYPSYP.......PFSLIKRN..........ELEEKPYNNEy.lsEGLSDLIDINAEPAVENVQKQIMSQAKIFEAIKEASKEIFRQKSNRQ---kmle..........................................
#=GC SS_cons                    ..................................XXXXXXXXXXXXXXXX-....XXXXXXX..XXXXXXXXXX..XXXX.XXXX........XXX--SSSSS--XXXXXXXXXXX.......XXX-----..........XXXXXXXXXX....XXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..............................................
#=GC seq_cons                   ..........................................h.hhhhhh.....h.ss.s...h..p..p..p...tp..............pKRPFCNAFTGCG+KRop.......................................p....tshtsh..hps-.t.-pl.+QhhopsKlaEsIpEAphEl..pppt...................................................
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