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Database: Pfam
Entry: CCAP
LinkDB: CCAP
Original site: CCAP 
#=GF ID   CCAP
#=GF AC   PF11105.7
#=GF DE   Arthropod cardioacceleratory peptide 2a
#=GF AU   Pollington J, Finn RD
#=GF SE   PRODOM
#=GF GA   20.30 20.30;
#=GF TC   20.40 20.40;
#=GF NC   20.10 20.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   18521612
#=GF RT   Pleiotropic effects of the neuropeptides CCAP and myosuppressin
#=GF RT   in the beetle, Tenebrio molitor L. 
#=GF RA   Wasielewski O, Skonieczna M; 
#=GF RL   J Comp Physiol [B]. 2008; [Epub ahead of print]
#=GF DR   INTERPRO; IPR024276;
#=GF CC   CCAP exerts a reversible and dose-dependant cardio-stimulatory
#=GF CC   effect on the semi-isolated heart of experimental beetles. CCAP
#=GF CC   also increases free hemolymph sugar concentration in young
#=GF CC   larvae and adults of the meal-worm beetle [1].
#=GF SQ   47
#=GS G6D6R9_DANPL/2-124        AC G6D6R9.1
#=GS Q7PM76_ANOGA/4-148        AC Q7PM76.3
#=GS E0VG48_PEDHC/14-74        AC E0VG48.1
#=GS A0A194QFJ6_PAPXU/3-121    AC A0A194QFJ6.1
#=GS B4LXC8_DROVI/2-136        AC B4LXC8.2
#=GS W5JS42_ANODA/4-148        AC W5JS42.1
#=GS B0WGM9_CULQU/5-150        AC B0WGM9.1
#=GS B4G5V3_DROPE/2-141        AC B4G5V3.1
#=GS A0A088AGJ3_APIME/2-79     AC A0A088AGJ3.1
#=GS A0A158NDE0_ATTCE/1-111    AC A0A158NDE0.1
#=GS B4R0P9_DROSI/2-139        AC B4R0P9.1
#=GS Q29AT4_DROPS/2-141        AC Q29AT4.2
#=GS H9JJA5_BOMMO/80-161       AC H9JJA5.1
#=GS Q17NP9_AEDAE/3-142        AC Q17NP9.1
#=GS X1WNB0_ACYPI/61-110       AC X1WNB0.1
#=GS B3LZU0_DROAN/2-140        AC B3LZU0.1
#=GS N6U4D1_DENPD/5-123        AC N6U4D1.1
#=GS A0A067QIJ7_ZOONE/65-114   AC A0A067QIJ7.1
#=GS B4N9R1_DROWI/2-142        AC B4N9R1.1
#=GS T1J0Y2_STRMM/17-51        AC T1J0Y2.1
#=GS A0A0L0CD54_LUCCU/2-129    AC A0A0L0CD54.1
#=GS A0A0B4J2Q2_NASVI/233-296  AC A0A0B4J2Q2.1
#=GS E2B4A4_HARSA/1-89         AC E2B4A4.1
#=GS B4KAC6_DROMO/2-137        AC B4KAC6.1
#=GS B7Q5V5_IXOSC/6-114        AC B7Q5V5.1
#=GS A0A0Q9WG58_DROVI/1-84     AC A0A0Q9WG58.1
#=GS A0A164V9U8_9CRUS/6-109    AC A0A164V9U8.1
#=GS F1AHD5_RHOPR/59-108       AC F1AHD5.1
#=GS A0A0N0PE17_PAPMA/7-142    AC A0A0N0PE17.1
#=GS F1AHD5_RHOPR/3-65         AC F1AHD5.1
#=GS F0ZYL1_DICPU/49-141       AC F0ZYL1.1
#=GS A0A0L7QVQ8_9HYME/1-73     AC A0A0L7QVQ8.1
#=GS A0A0N1IU45_9HYME/3-106    AC A0A0N1IU45.1
#=GS T1H3H6_MEGSC/3-96         AC T1H3H6.1
#=GS D6WA20_TRICA/1-119        AC D6WA20.1
#=GS B0XKC5_CULQU/5-150        AC B0XKC5.1
#=GS A0A067QIJ7_ZOONE/5-70     AC A0A067QIJ7.1
#=GS H9JJA5_BOMMO/1-84         AC H9JJA5.1
#=GS A0A084WU59_ANOSI/6-151    AC A0A084WU59.1
#=GS X1WNB0_ACYPI/4-65         AC X1WNB0.1
#=GS B4JIE3_DROGR/2-136        AC B4JIE3.1
#=GS B4HES2_DROSE/2-139        AC B4HES2.1
#=GS A0A0K9Y1I8_9FLAO/2-77     AC A0A0K9Y1I8.1
#=GS E9HE05_DAPPU/6-104        AC E9HE05.1
#=GS CCAP_DROME/2-139          AC Q9VCW0.2
#=GS CCAP_DROME/2-139          DR PDB; 1Y49 A; 1-9;
#=GS E0VG48_PEDHC/69-118       AC E0VG48.1
#=GS H3DZA4_PRIPA/226-301      AC H3DZA4.1
G6D6R9_DANPL/2-124                   ..............................sstsras-------L-LIIALLCL....DCCYSA...TIPR...............PFDPRL..TEev......ilsPKKRPFCNAFTGCGRKRS.Q.......ATPGMPMNEIARQRQFVD-..-.-.----.......EDAIESLVD--.SDMTIDELSRQIL.TEAKLWEAIQEASAEIARRKQKEM-y.................................................
Q7PM76_ANOGA/4-148                   .....................................RTAAKLLLAV-VSLFCVlqmlECGVVD...RQPR...............AYKQYN..TE...........PQKRPFCNAFTGCGKKRS.SasspptaAAAAAAAAMLQRHLQTMDP..G.R.KDRMgsdfdpnEESISSLLDLN.TEPAVEDLLRQIM.SEAKLWEAIQEANREIYLQKSGMK-d.................................................
E0VG48_PEDHC/14-74                   ...............fafiylitltfvtgddvilqkr-----------------....----SE...RNRL...............DMDRFM..YDg.........hAMKRPFCNAFTGCGKKRS.E.......-------------------..-.-.----.......-----------.-------------.-------------------------gsig..............................................
A0A194QFJ6_PAPXU/3-121               ..................................sfs----RVFLLIAIASLYM....ESCHSA...TIPR...............NFDSRL..TDdv......imtPKKRPFCNAFTGCGRKRS.Q.......YAPGMPQDII-RQRQYVD-..-.-.----.......DDTLGSLVE--.SENAVDELSRQIL.SEAKLWEAIQEASAEILRRKQK---..................................................
B4LXC8_DROVI/2-136                   ....................................r-ATVEIFLGLAAIIICL....YTANAS...LEIEnnev......nhklsGVIQWK..YE...........--KRPFCNAFTGCGRKRT.S.......YPSYPPFSLIKRNEPEEKP..Y.N.NEYL.......SEGLSDLIDIN.AEPAVENVQKQIM.SQAKIFEAIKEASKEIFRQKNKQKM..................................................
W5JS42_ANODA/4-148                   ....................................a-TSAKLLLTL-GALFCVlqmlECGVVD...RQPR...............AYRQYS..SE...........PQKRPFCNAFTGCGKKRS.TatsppstAASAAAAAMLQRHLQNMES..A.R.KDRSggdfdpnEESISSLLDLN.TEPAVEDLLRQIM.SEAKLWEAIQEANREIYLQKSG---vnq...............................................
B0WGM9_CULQU/5-150                   ...............................tvtslf----ALTVAMAFFIHVI....DCGVVD...REPR...............AYKQYN..TNsntagggggevPAKRPFCNAFTGCGKKRS.S.......-VAVTPVAMMHRHALTSE-..Q.N.RPKVtegfdpnEDSLANLIDLN.TEPAVEDLMRQIM.SEAKLWEAIQEANREIYLQKQGQK-t.................................................
B4G5V3_DROPE/2-141                   ....................................k-SSLKMCLGLVVLLICM....LSGNAS...LEREnnevnn..lanhklsGVIQWK..YE...........--KRPFCNAFTGCGRKRT.S.......YPSYPPFSLIKRNELEEKP..Y.N.NEYL.......SEGLSDLIDIN.AEPAVENVQKQIM.SQAKIFEAIKEASKEIFRQKSNR--qkm...............................................
A0A088AGJ3_APIME/2-79                .........................kiinyvccilaf-----------VCLMNVi.rsEESQSK...MEQQ...............FLDVFT..TDe........slKMKRPFCNAFTGCGKKRN.F.......-------------------..-.-.----.......-----------.-------------.-------------------------henptdsqdleingnir.................................
A0A158NDE0_ATTCE/1-111               ...............................mkitky---------LCCTLACMc.llKVANTE...ISRDkfe........rllnALNAEK..TI...........KSKRPFCNAFTGCGRFVS.E.......-------------------..-.-.----.......-----------.-------------.-------------------------errmkkkgpstlrdlsdfevtnnnvqlpvslyralldaakqnvwkvvdhe
B4R0P9_DROSI/2-139                   .....................................RTSMRISLRLLALLACA....ICSQAS...LEREnnegpn..manhklsGVIQWK..YE...........--KRPFCNAFTGCGRKRT.-.......YPSYPPFSLFKRNEVEEKP..Y.N.NEYL.......SEGLSDLIDIN.AEPAVENVQKQIM.SQAKIFEAIKEASKEIFRQKNKQKM..................................................
Q29AT4_DROPS/2-141                   ....................................k-SSLKMCLGLVVLLICM....LSGNAS...LEREnnevnn..lanhklsGVIQWK..YE...........--KRPFCNAFTGCGRKRT.S.......YPSYPPFSLIKRNELEEKP..Y.N.NEYL.......SEGLSDLIDIN.AEPAVENVQKQIM.SQAKIFEAIKEASKEIFRQKSNR--qkm...............................................
H9JJA5_BOMMO/80-161                  ..............................cfkhvlf-----------------....------...----...............------..--...........---------YQGCGRKRS.Q.......TAPGMPNQDLMRQRQYVD-..-.-.----.......EDTLGTMLD--.SESAIDELSRQIL.SEAKLWEAIQEASAEIARRKQKE--fy................................................
Q17NP9_AEDAE/3-142                   ....................................s-TAVTILLALAVTILCLahviDCGVVD...REPR...............AYKQYS..NEp.........pPAKRPFCNAFTGCGKKRS.S.......VVPVTPVNMIHRHALTSE-..Q.N.RPKVtegfdpnEDSLANLIDLN.TEPAVEDLMRQIM.SEAKLWEAIQEANREIYLQKQGQK-s.................................................
X1WNB0_ACYPI/61-110                  ....................................s-----------------....------...----...............------..--...........------------------.-.......-------------------..-.-.----.......DESMATLVDLR.SEPAVEEISRQIM.SEAKLWEAIQEARLELIRQQRQNK-a.................................................
B3LZU0_DROAN/2-140                   .................................tspi----KNSLRMAVLLVFV....ISCQAS...LEREnsevnn..lsnhklsGVIQWK..YE...........--KRPFCNAFTGCGRKRT.S.......YPSYPPFSLIKRNEIEEKP..Y.N.NEYL.......SEGLSDLIDIN.AEPAVENVQKQIM.SQAKIFEAIKEASKEIFRQKNKQK-l.................................................
N6U4D1_DENPD/5-123                   .....tlisvvlystamiliieldalfipkrmdpvls-----------------....------...----...............ARERII..LD...........PKKRPFCNAFTGCGRKRS.N.......LPAL-----------FSD-..-.-.GQEM.......ENSINSLLELS.AEPSVEDLSRQIM.SEAKLWEAIQEANLELKKHKNRP--ml................................................
A0A067QIJ7_ZOONE/65-114              ....................................s-----------------....------...----...............------..--...........------------------.-.......-------------------..-.-.----.......DESMGTLVELN.SEPAVEDLSRKIL.SETKLWEAIQEARAELLRRRQEQ--lq................................................
B4N9R1_DROWI/2-142                   ....................................n-ISTKLCLWLALLLFSV....LCGSAS...LERErqtnevnnlsnhklsGVIQWK..YE...........--KRPFCNAFTGCGRKRT.S.......YPSYPPFSLIKRNDIDDKP..Y.N.NEYM.......SEGLSDLIDIN.AEPAVENVQKQIM.SQAKIFEAIKEASKEIFRQKNKQK-l.................................................
T1J0Y2_STRMM/17-51                   ............................fsctigcaa-----------------....------...----...............------..--...........QKRRPFCNAFTGCGRKRS.E.......LPAS---------------..-.-.----.......-----------.-------------.-------------------------nvn...............................................
A0A0L0CD54_LUCCU/2-129               ..............................ltlkpcl------LLCLLSAHLCY...aTEAEAN...HKLS...............GIIQWK..YE...........--KRPFCNAFTGCGKKRT.-.......-SSHPPYPVIKRGDIEDKSlyN.S.NDYI.......SEGLSDLIDIN.AEPAVENVQKQIM.SQAKIYEAIKEASKEIFRQKNKQR-l.................................................
A0A0B4J2Q2_NASVI/233-296             ................................keqvl----KLVLSLLIIIESV....EIARAD...DGLE...............------..IV...........AMKRPFCNAFTGCGRKRDpS.......YA-----------------..-.-.----.......-----------.-------------.-------------------------sglqlpiplyra......................................
E2B4A4_HARSA/1-89                    .....................masseisrdkferqll-----------------....------...----...............--DALT..TEr........tmKPKRPFCNAFTGCGRKRS.F.......SASIPTL------------..-.-.----.......-----------.-------------.-------------------------rdsqdfrandnvrlpvslyralllnaakqntwdaidre............
B4KAC6_DROMO/2-137                   ....................................s-ASVEICFYLTAILICM....YTANAS...LETEnnev......nhklsGVIQWK..YE...........--KRPFCNAFTGCGRKRT.S.......YPSYPPFSLIKRNELEEKP..Y.NnNEYL.......SEGLSDLIDIN.AEPAVENVQKQIM.SQAKIFEAIKEASKEIFRQKNKQKM..................................................
B7Q5V5_IXOSC/6-114                   ...............................stviss------SLYILLLSACL....SAALEK...QDDT...............ADDSYL..VE...........-QKRPFCNAFTGCGGKRS.S.......PNRIDLLARLQNRLL----..-.-.----.......-----------.-------------.-------------------------seirnlelrtrleegpsrrhdeytdnvsrlnkreesisdas.........
A0A0Q9WG58_DROVI/1-84                ...................................mk-----------------....------...----...............------..--...........-----------CCGRKRT.S.......YPSYPPFSLIKRNEPEEKP..Y.N.NEYL.......SEGLSDLIDIN.AEPAVENVQKQIM.SQAKIFEAIKEASKEIFRQKNKQKM..................................................
A0A164V9U8_9CRUS/6-109               ...........................yslvvlawlv--------------ISL....YVSNSL...SQPLtanqn....dsdsieDVEQWS..YK...........-EKRPFCNAFAGCGRKRS.M.......VSKENKHS-----------..-.-.----.......-----------.-------------.-------------------------aygkapsnhprplntntkllenivarlqnkranaiq..............
F1AHD5_RHOPR/59-108                  ....................................s-----------------....------...----...............------..--...........------------------.-.......-------------------..-.-.----.......DESMATLVDLN.SEPAVEELSRQIL.SEAKLWEAIQEARMELLNRKQQQS-d.................................................
A0A0N0PE17_PAPMA/7-142               vvpaclhvdmserderalasgwgatqnrgssadilqk-----------------....------...-IPR...............NFDSRL..SDdv......imtPKKRPFCNAFTGCGRKRS.Q.......YAPGMPQD-IGRQRQYVD-..-.-.----.......DETLGSLVD--.SENAIDELSRQIL.SEAKLWEAIQEASAEVLRRKQKE--yn................................................
F1AHD5_RHOPR/3-65                    ........................llvpcfllftalv--------------SAV....LTDDVF...LQKR...............LYFPGE..IAep......idpKMKKPFCNAFTGCGKKRS.D.......E------------------..-.-.----.......-----------.-------------.-------------------------smat..............................................
F0ZYL1_DICPU/49-141                  .................yniegylnkeinngsiqidt-----------------....------...-YNM...............GTNQPN..YY...........DEIKDFCNVFTNCPYKAG.S.......FSESISFNMNNNNKNNNNN..N.N.NNNL.......-----------.-------------.-------------------------ffttflaideidiktlhp................................
A0A0L7QVQ8_9HYME/1-73                ...........mclinagqsekplnkidqqlldafnv-----------------....------...----...............------..-Dr........slRMKRPFCNAFTGCGRKRS.F.......SEYLTDLQELKS-------..-.-.----.......-----------.-------------.-------------------------sdsiripvslyk......................................
A0A0N1IU45_9HYME/3-106               ............nnvccififvwlvnaahsegpqdki-----------------....------...-EQQ...............FLDTFT..TDe........llKIKRPFCNAFTGCGKKRN.F.......-------------------..-.-.----.......-----------.-------------.-------------------------henpvdsqdmgasgsirlpifvykallraaaqniqntiqrnmndyq....
T1H3H6_MEGSC/3-96                    ......................qrevsvcqetqypav-----------------....------...----...............------..--...........---------VKGCGRKRS.-.......---RPDINQLPYHQTPTQ-..Y.Q.PKSV.......HEILSDFIDLD.AEPAVKDVQQQIM.SQAKFLEAIKEATKEIYDGETK---pke...............................................
D6WA20_TRICA/1-119                   ................mttaklfvicifaalaieths-----------------....------...---Rflpks.....isknlGATERV..LE...........PKKRPFCNAFTGCGRKRS.N.......LPALP--------------..E.Q.SEVV.......DENLGSLLELS.AEPAVEDLSRQIM.SEAKLWEAIQEANMELHRRRQE---sae...............................................
B0XKC5_CULQU/5-150                   ...............................tvtslf----ALTVAMAFFIHVI....DCGVVD...REPR...............AYKQYN..TNsnsagggggevPAKRPFCNAFTGCGKKRS.S.......-VAVTPVAMMHRHALTSE-..Q.N.RPKVtegfdpnEDSLANLIDLN.TEPAVEDLMRQIM.SEAKLWEAIQEANREIYLQKQGQK-t.................................................
A0A067QIJ7_ZOONE/5-70                .............................hvvigcsv----AVL----LMIIGLp.laSCDSVI...IQKR...............QIDPAD..VDri......ldpKRKRPFCNAFTGCGKKRS.D.......-------------------..-.-.----.......-----------.-------------.-------------------------esmg..............................................
H9JJA5_BOMMO/1-84                    ...................................mt---SRVLLVLVVALLCA....ECCVTA...TIPR...............NFDPRS..NEem......vtmPKKRPFCNAFTAVTVTRY.S.......QSFSKNYLSIRRLRALTKP..I.-.----.......-----------.-------------.-------------------------kcfkhv............................................
A0A084WU59_ANOSI/6-151               ..................................knc---AKMMLAVMVT-FCVlqmlECGVVD...RQPR...............AYKQYN..TE...........PQKRPFCNAFTGCGKKRS.SasspptaSAAAAAAAILQRHMQNMEA..NsK.KERVtsdyepnEESISSLLDLN.TEPAVEDLLRQIM.SEAKLWEAIQEANREIFLQKSGMK-e.................................................
X1WNB0_ACYPI/4-65                    .............................siltlvwm----------SILVSLV....QTVFADdviMQKR...............YFDNDNpvAEp.........iRRKKPFCNAFTGCGRKRS.D.......-------------------..-.-.----.......-----------.-------------.-------------------------esm...............................................
B4JIE3_DROGR/2-136                   .....................................RTTLEIFLCLAAIFLFA....YSADAS...LETEnnev......nhklsGVIQWK..FE...........--KRPFCNAFTGCGRKRT.S.......YPSYPPFSLFKRNEIEEKP..Y.N.NEYL.......SEGLSDLIDIN.AEPAVENVQKQIM.SQAKIFEAIKEASKEIFRQKNKQK-l.................................................
B4HES2_DROSE/2-139                   .....................................RTSMRISLRLLALLACA....ICSQAS...LEREnnegpn..manhklsGVIQWK..YE...........--KRPFCNAFTGCGRKRT.-.......YPSYPPFSLFKRNEVDEKP..Y.N.NEYL.......SEGLSDLIDIN.AEPAVENVQKQIM.SQAKIFEAIKEASKEIFRQKNKQKM..................................................
A0A0K9Y1I8_9FLAO/2-77                ....................reiyqskkrsikymqal-----------------....------...----...............------..--...........------------------.-.......--------------QEKKM..E.L.AEKL.......EEFQNYHIELTkKEEDFKNMGKQIM.HNAKCWENLKKSSKEHIVRN-----sqn...............................................
E9HE05_DAPPU/6-104                   ..................................fys------LLMLAWMIISL....YISASS...SQPLknnqn....dsdsaeEIEQWS..FK...........-EKRPFCNAFAGCGRKRS.M.......IK-----------------..-.-.----.......-----------.-------------.-------------------------dtkhppyekaasnhprlpnadtklldklfakiqhqr..............
CCAP_DROME/2-139                     .....................................RTSMRISLRLLALLACA....ICSQAS...LEREnnegtn..manhklsGVIQWK..YE...........--KRPFCNAFTGCGRKRT.-.......YPSYPPFSLFKRNEVEEKP..Y.N.NEYL.......SEGLSDLIDIN.AEPAVENVQKQIM.SQAKIFEAIKEASKEIFRQKNKQKM..................................................
#=GR CCAP_DROME/2-139          SS    .....................................XXXXXXXXXXXXXXXXX....XXXXXX...XXXXXXXXXX..XXXXXXXXXXXXX..XX...........--XX--SSSSS--XXXXX.-.......XXXXXXXXXXXXXXXXXXX..X.X.XXXX.......XXXXXXXXXXX.XXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXX..................................................
E0VG48_PEDHC/69-118                  ....................................s-----------------....------...----...............------..--...........------------------.-.......-------------------..-.-.----.......EGSIGNILGFN.TEPESDELLKQFL.TEAKLWETIQEAKMELERRRQGRQ-n.................................................
H3DZA4_PRIPA/226-301                 ........................gygrvgavvflet-----------------....------...----...............------..--...........------------------.-.......------------RLDLSKE..Q.A.RNRL.......DEAINEMIDIN.SHRRVEEKLQCLLrCSHKIFDSLRESGTDINHES-----lkmsr.............................................
#=GC SS_cons                         .....................................XXXXXXXXXXXXXXXXX....XXXXXX...XXXXXXXXXX..XXXXXXXXXXXXX..XX...........--XX--SSSSS--XXXXX.-.......XXXXXXXXXXXXXXXXXXX..X.X.XXXX.......XXXXXXXXXXX.XXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXX..................................................
#=GC seq_cons                        ....................................h................h......s.s.......p...............th.th...h-.............KRPFCNAFTGCG+KRo.p........s..................................p-shsshl-...sE.sl-pl.+QIh.opAKlaEuIpEAphElhhpppt.....................................................
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