GenomeNet

Database: Pfam
Entry: CDKN3
LinkDB: CDKN3
Original site: CDKN3 
#=GF ID   CDKN3
#=GF AC   PF05706.9
#=GF DE   Cyclin-dependent kinase inhibitor 3 (CDKN3)
#=GF AU   Moxon SJ
#=GF SE   Pfam-B_5217 (release 8.0)
#=GF GA   20.70 20.70;
#=GF TC   20.70 20.70;
#=GF NC   20.60 20.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   8127873
#=GF RT   KAP: a dual specificity phosphatase that interacts with
#=GF RT   cyclin-dependent kinases. 
#=GF RA   Hannon GJ, Casso D, Beach D; 
#=GF RL   Proc Natl Acad Sci U S A 1994;91:1731-1735.
#=GF RN   [2]
#=GF RM   10987270
#=GF RT   Aberrant transcripts of the cyclin-dependent kinase-associated
#=GF RT   protein phosphatase in hepatocellular carcinoma. 
#=GF RA   Yeh CT, Lu SC, Chen TC, Peng CY, Liaw YF; 
#=GF RL   Cancer Res 2000;60:4697-4700.
#=GF DR   INTERPRO; IPR022778;
#=GF DR   SCOP; 1fq1; fa;
#=GF CC   This family consists of cyclin-dependent kinase inhibitor 3 or
#=GF CC   kinase associated phosphatase proteins from several mammalian
#=GF CC   species. The cyclin-dependent kinase (Cdk)-associated protein
#=GF CC   phosphatase (KAP) is a human dual specificity protein
#=GF CC   phosphatase that dephosphorylates Cdk2 on threonine 160 in a
#=GF CC   cyclin-dependent manner [1,2].
#=GF SQ   155
#=GS T1JGM7_STRMM/1-165       AC T1JGM7.1
#=GS A5GFF1_GEOUR/33-169      AC A5GFF1.1
#=GS I3MH53_SPETR/1-167       AC I3MH53.1
#=GS Q55FR4_DICDI/67-216      AC Q55FR4.1
#=GS I0HLL3_RUBGI/11-157      AC I0HLL3.1
#=GS R1BR51_EMIHU/329-401     AC R1BR51.1
#=GS R1E8P7_EMIHU/116-183     AC R1E8P7.1
#=GS H2TMA6_TAKRU/5-174       AC H2TMA6.1
#=GS E1SNA7_FERBD/20-133      AC E1SNA7.1
#=GS Q7NLX9_GLOVI/11-172      AC Q7NLX9.1
#=GS F6XTU8_CALJA/1-161       AC F6XTU8.1
#=GS F9ZVT9_METMM/9-157       AC F9ZVT9.1
#=GS W5LQ75_ASTMX/4-171       AC W5LQ75.1
#=GS D3RQZ9_ALLVD/15-157      AC D3RQZ9.1
#=GS A8J277_CHLRE/170-242     AC A8J277.1
#=GS M9R7L3_9RHOB/40-139      AC M9R7L3.1
#=GS C4LZS6_ENTHI/153-295     AC C4LZS6.1
#=GS F7FIA4_MACMU/1-51        AC F7FIA4.1
#=GS A0A0D9RQQ6_CHLSB/1-168   AC A0A0D9RQQ6.1
#=GS W5N1L8_LEPOC/7-171       AC W5N1L8.1
#=GS B3S0H8_TRIAD/54-130      AC B3S0H8.1
#=GS H7C0S3_HUMAN/1-167       AC H7C0S3.1
#=GS M3X5Z7_FELCA/49-153      AC M3X5Z7.1
#=GS G3H7C0_CRIGR/29-156      AC G3H7C0.1
#=GS F6UZN6_MONDO/1-168       AC F6UZN6.2
#=GS Q7MQA7_VIBVY/11-148      AC Q7MQA7.1
#=GS A0A087WW25_HUMAN/1-35    AC A0A087WW25.1
#=GS F6X5L7_CALJA/1-168       AC F6X5L7.1
#=GS U3IB04_ANAPL/1-127       AC U3IB04.1
#=GS F4F9I4_VERMA/30-135      AC F4F9I4.1
#=GS A4YTM6_BRASO/25-131      AC A4YTM6.1
#=GS A1K8V5_AZOSB/5-159       AC A1K8V5.1
#=GS F1SFD7_PIG/1-168         AC F1SFD7.2
#=GS B8PPF8_POSPM/381-520     AC B8PPF8.1
#=GS G3TDY3_LOXAF/1-171       AC G3TDY3.1
#=GS CDKN3_PIG/1-168          AC Q9MYN5.1
#=GS A0A0A7KGT1_9DEIO/75-156  AC A0A0A7KGT1.1
#=GS G3QSG9_GORGO/1-168       AC G3QSG9.1
#=GS G1SIX6_RABIT/1-168       AC G1SIX6.1
#=GS D8LRV7_ECTSI/214-293     AC D8LRV7.1
#=GS D8TV47_VOLCA/8-177       AC D8TV47.1
#=GS Q11SI3_CYTH3/224-410     AC Q11SI3.1
#=GS V8PHU9_OPHHA/1-169       AC V8PHU9.1
#=GS F6X4Q9_CALJA/1-50        AC F6X4Q9.1
#=GS F7FIB7_MACMU/1-168       AC F7FIB7.1
#=GS H2Q8C0_PANTR/1-168       AC H2Q8C0.1
#=GS M2QZT8_CERS8/369-513     AC M2QZT8.1
#=GS D2VVL2_NAEGR/6-162       AC D2VVL2.1
#=GS I3L7E6_PIG/1-29          AC I3L7E6.1
#=GS L5LMN1_MYODS/19-176      AC L5LMN1.1
#=GS A0A096NV50_PAPAN/1-168   AC A0A096NV50.1
#=GS M4NDI1_9GAMM/12-160      AC M4NDI1.1
#=GS Q1IZZ9_DEIGD/1-153       AC Q1IZZ9.1
#=GS A4AD49_9GAMM/18-158      AC A4AD49.2
#=GS B8LDA9_THAPS/45-177      AC B8LDA9.1
#=GS H2RZW5_TAKRU/1-136       AC H2RZW5.1
#=GS F7FIA4_MACMU/49-68       AC F7FIA4.1
#=GS CDKN3_RAT/1-168          AC B2RZ50.1
#=GS Q21C89_RHOPB/23-152      AC Q21C89.1
#=GS F0LR07_VIBFN/14-141      AC F0LR07.1
#=GS F6VTZ2_HORSE/1-165       AC F6VTZ2.1
#=GS W5N1L0_LEPOC/1-162       AC W5N1L0.1
#=GS F4PL73_DICFS/58-179      AC F4PL73.1
#=GS J4H4N6_FIBRA/193-321     AC J4H4N6.1
#=GS Q31MW0_SYNE7/5-128       AC Q31MW0.1
#=GS F7C0H9_CALJA/4-123       AC F7C0H9.1
#=GS A0A0C5XSE9_9MYCO/38-139  AC A0A0C5XSE9.1
#=GS G1P8L2_MYOLU/1-66        AC G1P8L2.1
#=GS A9U3E8_PHYPA/415-542     AC A9U3E8.1
#=GS F6X4M9_CALJA/5-128       AC F6X4M9.1
#=GS F1NIB9_CHICK/1-163       AC F1NIB9.2
#=GS H0V2L8_CAVPO/1-163       AC H0V2L8.1
#=GS E2RDA9_CANFA/1-168       AC E2RDA9.1
#=GS E4N6S1_KITSK/28-133      AC E4N6S1.1
#=GS A0A087YGI7_POEFO/1-163   AC A0A087YGI7.2
#=GS A0A0C4ES03_PUCT1/68-161  AC A0A0C4ES03.1
#=GS Q32PC4_BOVIN/1-65        AC Q32PC4.1
#=GS A1T0Q6_PSYIN/2-142       AC A1T0Q6.1
#=GS M3X5Z7_FELCA/1-50        AC M3X5Z7.1
#=GS D5AQF6_RHOCB/62-186      AC D5AQF6.1
#=GS H9GNC7_ANOCA/2-167       AC H9GNC7.1
#=GS Q32PC4_BOVIN/64-123      AC Q32PC4.1
#=GS M3WLX1_FELCA/1-165       AC M3WLX1.1
#=GS G3W4P3_SARHA/1-168       AC G3W4P3.1
#=GS H3DPU4_TETNG/6-172       AC H3DPU4.1
#=GS F6XTN7_CALJA/1-34        AC F6XTN7.1
#=GS G3V1K6_HUMAN/1-144       AC G3V1K6.1
#=GS A0A0C4F787_PUCT1/99-191  AC A0A0C4F787.1
#=GS G1M9X4_AILME/1-165       AC G1M9X4.1
#=GS A0A067RTQ0_ZOONE/1-159   AC A0A067RTQ0.1
#=GS H2NLA0_PONAB/1-168       AC H2NLA0.1
#=GS F7FI99_MACMU/1-79        AC F7FI99.1
#=GS Q5E292_VIBF1/6-142       AC Q5E292.1
#=GS B8A6D9_DANRE/1-163       AC B8A6D9.1
#=GS CDKN3_MOUSE/1-167        AC Q810P3.1
#=GS H0ZS88_TAEGU/1-167       AC H0ZS88.1
#=GS K1P547_CRAGI/12-180      AC K1P547.1
#=GS Q1AWZ2_RUBXD/3-155       AC Q1AWZ2.1
#=GS B0EMD8_ENTDS/146-295     AC B0EMD8.1
#=GS Q2GBR6_NOVAD/25-154      AC Q2GBR6.1
#=GS Q9RSG3_DEIRA/2-151       AC Q9RSG3.1
#=GS L5K451_PTEAL/18-165      AC L5K451.1
#=GS G1P8L2_MYOLU/64-123      AC G1P8L2.1
#=GS W5QIU2_SHEEP/1-71        AC W5QIU2.1
#=GS W0E410_MARPU/7-157       AC W0E410.1
#=GS H3BII6_LATCH/1-163       AC H3BII6.2
#=GS V4L294_9GAMM/25-138      AC V4L294.1
#=GS H0X109_OTOGA/1-165       AC H0X109.1
#=GS A0KFJ7_AERHH/52-164      AC A0KFJ7.1
#=GS W5QIU2_SHEEP/70-129      AC W5QIU2.1
#=GS W4XJA3_STRPU/19-183      AC W4XJA3.1
#=GS F6X4Q9_CALJA/48-67       AC F6X4Q9.1
#=GS E3JTT3_PUCGT/365-503     AC E3JTT3.1
#=GS H2LZB8_ORYLA/6-174       AC H2LZB8.1
#=GS I4B6D8_TURPD/613-749     AC I4B6D8.1
#=GS G5BF85_HETGA/1-164       AC G5BF85.1
#=GS F7D748_ORNAN/1-165       AC F7D748.1
#=GS X6MX87_RETFI/1-139       AC X6MX87.1
#=GS B1XWQ7_LEPCP/34-180      AC B1XWQ7.1
#=GS Q87KK8_VIBPA/11-143      AC Q87KK8.1
#=GS A9UZS3_MONBE/431-522     AC A9UZS3.1
#=GS C1D2W7_DEIDV/2-125       AC C1D2W7.1
#=GS F7FIB2_MACMU/5-128       AC F7FIB2.1
#=GS C3Z3W3_BRAFL/1-161       AC C3Z3W3.1
#=GS G3V2J7_HUMAN/1-168       AC G3V2J7.1
#=GS D3RMS8_ALLVD/22-151      AC D3RMS8.1
#=GS V4C3P3_LOTGI/6-169       AC V4C3P3.1
#=GS B5HAS8_STRPR/101-205     AC B5HAS8.1
#=GS B7PP47_IXOSC/1-160       AC B7PP47.1
#=GS G3PDB3_GASAC/1-168       AC G3PDB3.1
#=GS F5H232_HUMAN/1-146       AC F5H232.1
#=GS M3ZZM5_XIPMA/2-146       AC M3ZZM5.1
#=GS A0A0C4FDG6_PUCT1/1-89    AC A0A0C4FDG6.1
#=GS B2FU04_STRMK/4-155       AC B2FU04.1
#=GS H2G0X6_OCESG/24-140      AC H2G0X6.1
#=GS Q31GI9_THICR/3-115       AC Q31GI9.1
#=GS U3JMH5_FICAL/35-203      AC U3JMH5.1
#=GS F8WD24_HUMAN/1-122       AC F8WD24.1
#=GS CDKN3_HUMAN/1-168        AC Q16667.1
#=GS CDKN3_HUMAN/1-168        DR PDB; 1FPZ A; 21-168;
#=GS CDKN3_HUMAN/1-168        DR PDB; 1FPZ C; 21-168;
#=GS CDKN3_HUMAN/1-168        DR PDB; 1FPZ F; 21-168;
#=GS CDKN3_HUMAN/1-168        DR PDB; 1FQ1 A; 21-168;
#=GS CDKN3_HUMAN/1-168        DR PDB; 1FPZ B; 21-168;
#=GS CDKN3_HUMAN/1-168        DR PDB; 1FPZ E; 21-168;
#=GS CDKN3_HUMAN/1-168        DR PDB; 1FPZ D; 21-168;
#=GS D3SA60_THISK/4-154       AC D3SA60.1
#=GS A7HHK3_ANADF/4-92        AC A7HHK3.1
#=GS A0A087WWK3_HUMAN/1-163   AC A0A087WWK3.1
#=GS H8GT31_DEIGI/28-119      AC H8GT31.1
#=GS M3Y281_MUSPF/1-168       AC M3Y281.1
#=GS E1ZPG6_CHLVA/203-291     AC E1ZPG6.1
#=GS A9B1P9_HERA2/24-151      AC A9B1P9.1
#=GS G7PAA5_MACFA/1-165       AC G7PAA5.1
#=GS F0Z7V7_DICPU/85-202      AC F0Z7V7.1
#=GS F7G9Y7_CALJA/1-146       AC F7G9Y7.1
#=GS A8IRQ3_CHLRE/16-184      AC A8IRQ3.1
#=GS F7YSG3_VIBA7/10-144      AC F7YSG3.1
#=GS Q23R35_TETTS/4-148       AC Q23R35.1
#=GS I3KU47_ORENI/1-163       AC I3KU47.1
#=GS G1RQ90_NOMLE/1-168       AC G1RQ90.1
#=GS G1NLR3_MELGA/1-166       AC G1NLR3.1
T1JGM7_STRMM/1-165                  ........................................................................ma--------SSRFD.SS.SD.EEA.E..SpptD...T.Q.PLRIDWVD...LSIIGYPNSVGISQMP.G...C..KF..KN.....N.......W......RN.LKND.LETM.T.N.A.G...IQS.V.YV.LLTT.GEL..RK.....Y..R..A....S.....Q...L...L..D...E.YNS.S.G......I.....N.V..H..HYPFPD...G..T..V.P..T........V....D...I...V....V....N...F.I...Y...D....L...K..ED...L.G.......N..Q.R....K..TL.I..HCYG..GLGRS.C...F...L.V.ACFMLE....MDESLSPDRVI..................
#=GR T1JGM7_STRMM/1-165       pAS   .............................................................................................................................................................................................................................................................................................................................................................................................................*.............................................................
A5GFF1_GEOUR/33-169                 ..................................................esggvigmticpgkkdngyfsgfw-------------.--.--.---.-..-...-...-.-.--------...----------------.-...-..--..--.....-.......E......RN.LDAD.LQAI.K.D.W.G...AVA.L.VS.LIEG.FEF..RF.....L..Q..V....Q.....D...L...P..E...K.AGI.F.G......L.....R.W..M..HLPIPE...A..S..I.P..D........Q....-...S...F....E....E...I.W...Q...EagpqL...R..QW...L.K.......E..G.K....K..IV.L..HCNE..GFGRT.G...I...I.A.ARLLVE....LG---------vepddai...........
#=GR A5GFF1_GEOUR/33-169      pAS   .............................................................................................................................................................................................................................................................................................................................................................................................................*.............................................................
I3MH53_SPETR/1-167                  ..........................................................................MKPPISIQASEFD.SS.DE.EPI.E..D...E...Q.T.PIQISWLP...LSQVNCSQFLGLCALP.G...C..KF..KD.....V.......R......RN.IQKD.TEEL.K.S.Y.G...IQD.I.FV.FCTR.GEL..SK.....Y..R..V....P.....N...L...L..D...L.YQQ.Y.G......I.....T.T..H..HHPIPD...G..G..T.P..D........I....A...S...C....C....D...I.M...E...E....L...A..IC...L.K.......N..N.R....K..TL.I..HCYG..GLGRS.C...L...-.A.ACLLLY....LSDTVSPQQAI..................
#=GR I3MH53_SPETR/1-167       pAS   .............................................................................................................................................................................................................................................................................................................................................................................................................*.............................................................
Q55FR4_DICDI/67-216                 .....................................ddsddmkgpldttnwivkdsilcgeypgnkdddivhf-------------.--.--.---.-..-...-...-.-.--------...----------------.-...-..--..--.....-.......-......--.--KT.LSTL.L.D.S.G...IRV.F.VC.LQEQ.DEL..KK.....F..RpyR....E.....D...I...L..K...L.SKE.K.G......Idv.dsV.T..F.vHFPIED...G..G..I.A..E........N...nE...D...L....V....D...L.I...E...R....L...L..NL...L.S.......L..D.N....K..VY.L..HCWA..GRGRT.G...I...I.G.ACLLGR....L----------yqvtglea..........
#=GR Q55FR4_DICDI/67-216      pAS   .............................................................................................................................................................................................................................................................................................................................................................................................................*.............................................................
I0HLL3_RUBGI/11-157                 .......................................plqiaavraspahgrigvtfcpgkhdraaatgawa-------------.--.--.---.-..-...-...-.-.--------...----------------.-...-..--..--.....-.......-......RD.LGMD.LDTI.A.A.W.G...AKL.V.LT.LVEP.AEL..TA.....L..K..V....P.....Q...L...G..H...E.VKR.R.G......I.....A.W..W..HLPIPD...F..G..V.P..G........E....H...F...E....R....E...W.VaagA...E....I...R..AL...L.R.......A..G.D....D..VL.V..HCKG..GLGRA.G...M...I.A.ARLLAE....LG--VEPNQAI..................
#=GR I0HLL3_RUBGI/11-157      pAS   .............................................................................................................................................................................................................................................................................................................................................................................................................*.............................................................
R1BR51_EMIHU/329-401                ...................................................................apegaqf-------------.--.--.---.-..-...-...-.-.--------...----------------.-...-..--..--.....-.......-......--.----.----.-.-.-.-...---.-.--.----.---..--.....-..-..-....-.....-...-...-..-...-.---.-.-......-.....-.-..L..HFPIPD...R..G..V.A..D........S....P...E...A....L....D..gL.V...S...E....L...S..RR...A.L.......D..G.Q....V..LY.I..HCWG..GRGRT.G...M...V.A.ACLLGS....LYRYVGAE---eal...............
#=GR R1BR51_EMIHU/329-401     pAS   .............................................................................................................................................................................................................................................................................................................................................................................................................*.............................................................
R1E8P7_EMIHU/116-183                ......................................................................lkfa-------------.--.--.---.-..-...-...-.-.--------...----------------.-...-..--..--.....-.......-......--.----.----.-.-.-.-...---.-.--.----.---..--.....-..-..-....-.....-...-...-..-...-.---.-.-......-.....-.-..-..HFGIRD...M..H.pA.D..D........V....A...A...L....R....S...L.V...Y...E....L...A..RR...V.R.......T..G.E....V..LY.V..HCWG..GKGRA.G...L...V.C.ACLLAY....LYN--------igaeeal...........
#=GR R1E8P7_EMIHU/116-183     pAS   .............................................................................................................................................................................................................................................................................................................................................................................................................*.............................................................
H2TMA6_TAKRU/5-174                  ........................................................................vv--PVSGMRTSEFD.SSsEE.EEV.G..E...E...QlT.PLHISWLP...LSVVECSQFLGICALP.G...C..KY..KD.....V.......R......RS.LERD.VEEL.Q.N.Q.G...VQE.V.FV.FCSR.AEL..HR.....Y..R..V....P.....S...L...L..D...V.YQQ.R.G......F.....C.V..H..HMPFPD...G..D..V.P..E........L....E...Q...C....C....R...I.L...E...E....L...Q..TS...L.E.......N..N.R....R..TV.I..HCYG..GLGRS.G...L...I.A.ACLLLR....LSVSLTENKV-i.................
#=GR H2TMA6_TAKRU/5-174       pAS   .............................................................................................................................................................................................................................................................................................................................................................................................................*.............................................................
E1SNA7_FERBD/20-133                 ...................................................................apglegr-------------.--.--.---.-..-...-...-.-.--------...----------------.-...-..--..--.....-.......-......--.LKED.VALL.A.A.A.G...VAA.V.VT.TLTE.EEL..TR.....F..G..I....P.....T...L...G..Q...E.VEA.A.G......M.....Q.W..V..HLPVQD...K..S..L.P..D........Ae..fD...A...A....W...aE...Q.R...E...M....L...T..AL...M.E.......S..G.K....R..VS.V..HCRG..GTGRT.G...L...V.A.AKLLL-....-----------dsgadwq...........
#=GR E1SNA7_FERBD/20-133      pAS   .............................................................................................................................................................................................................................................................................................................................................................................................................*.............................................................
Q7NLX9_GLOVI/11-172                 ...............................................................dleldpparts-------------.--.--.---.-..-...D...T.D.PIRVDFLP...EGALGLAGRTGMCFAP.Gk.hClgKF..AL.....W.......R......RD.LEKD.LDRL.RrH.Y.G...SNW.L.VT.LVQA.HEL..VE.....L..K..I....P.....D...L...L..E...R.ARA.W.G......L.....T.S..R..WFPVRD...Y..G..I.P.tS........I....A...S...T....L....M...L.V...E...D....I...L..IA...N.G.......Q..G.K....T..VV.I..HCKG..GLGRT.G...L...V.A.ACCLVA....-----------rgyshseafe........
#=GR Q7NLX9_GLOVI/11-172      pAS   .............................................................................................................................................................................................................................................................................................................................................................................................................*.............................................................
F6XTU8_CALJA/1-161                  ........................................................................lk---PSSIQASEFD.SS.DE.EPI.E..D...E...Q.T.PIQISWLP...LSRVNCSQFLGLCALP.G...C..KF..KN.....V.......R......RN.VEKD.TEEL.K.S.C.G...IQD.I.FV.FCTR.GEL..SK.....Y..R..V....P.....N...L...L..D...L.YQQ.C.G......I.....I.T..H..HHPIAD...G..G..T.P..D........I....A...C...C....C....E...I.M...E...E....L...A..IC...L.P.......-..-.-....-..--.F..QCYG..GLGRS.C...L...V.A.ACLLLY....LSDTVSPEQAI..................
#=GR F6XTU8_CALJA/1-161       pAS   .............................................................................................................................................................................................................................................................................................................................................................................................................*.............................................................
F9ZVT9_METMM/9-157                  .....................................shplqiaevraspahgrigitfcpgkhdhfahtgawe-------------.--.--.---.-..-...-...-.-.--------...----------------.-...-..--..--.....-.......-......RD.LGID.LDVI.A.A.W.G...AKL.V.LT.LVEP.AEL..AA.....L..K..V....P.....Q...L...G..H...E.IRR.R.G......I.....A.W..H..HLPIAD...Y..S..V.P..T........Q....A...F...E....Q....Q...W.LskgR...E....I...R..EM...L.H.......N..G.D....D..IL.V..HCKG..GLGRA.G...M...I.A.ARLLAE....LG---------mdpedai...........
#=GR F9ZVT9_METMM/9-157       pAS   .............................................................................................................................................................................................................................................................................................................................................................................................................*.............................................................
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#=GR G1NLR3_MELGA/1-166       pAS   .............................................................................................................................................................................................................................................................................................................................................................................................................*.............................................................
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