GenomeNet

Database: Pfam
Entry: CENP-F_leu_zip
LinkDB: CENP-F_leu_zip
Original site: CENP-F_leu_zip 
#=GF ID   CENP-F_leu_zip
#=GF AC   PF10473.4
#=GF DE   Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
#=GF PI   Cenp-F_leu_zip;
#=GF AU   Buljan M, Coggill P
#=GF SE   TF101133
#=GF GA   33.00 33.00;
#=GF TC   33.00 33.20;
#=GF NC   32.90 32.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   7542657
#=GF RT   CENP-F is a protein of the nuclear matrix that assembles onto
#=GF RT   kinetochores at late G2 and is rapidly degraded after mitosis. 
#=GF RA   Liao H, Winkfein RJ, Mack G, Rattner JB, Yen TJ; 
#=GF RL   J Cell Biol. 1995;130:507-518.
#=GF RN   [2]
#=GF RM   14555653
#=GF RT   LEK1 is a potential inhibitor of pocket protein-mediated
#=GF RT   cellular processes. 
#=GF RA   Ashe M, Pabon-Pena L, Dees E, Price KL, Bader D; 
#=GF RL   J Biol Chem. 2004;279:664-676.
#=GF DR   INTERPRO; IPR019513;
#=GF CC   Cenp-F, a centromeric kinetochore, microtubule-binding protein
#=GF CC   consisting of two 1,600-amino acid-long coils, is essential for
#=GF CC   the full functioning of the mitotic checkpoint pathway [1,2].
#=GF CC   There are several leucine-rich repeats along the sequence of
#=GF CC   LEK1 that are considered to be zippers, though they do not
#=GF CC   appear to be binding DNA directly in this instance [2].
#=GF SQ   150
#=GS F1PRS3_CANFA/1795-1937  AC F1PRS3.1
#=GS G7NUK3_MACFA/1892-2034  AC G7NUK3.1
#=GS Q90YL2_CHICK/872-1011   AC Q90YL2.1
#=GS G5BUR9_HETGA/2210-2349  AC G5BUR9.1
#=GS H2N3Q4_PONAB/2130-2269  AC H2N3Q4.1
#=GS A4IUK0_YERRU/217-346    AC A4IUK0.1
#=GS G1RW78_NOMLE/1893-2035  AC G1RW78.1
#=GS H3AGZ6_LATCH/1901-2043  AC H3AGZ6.1
#=GS Q4RKR8_TETNG/265-370    AC Q4RKR8.1
#=GS C0GJU0_9FIRM/650-748    AC C0GJU0.1
#=GS C4NVP0_SALCE/217-346    AC C4NVP0.1
#=GS CENPF_HUMAN/1989-2131   AC P49454.2
#=GS G3TYB2_LOXAF/1971-2110  AC G3TYB2.1
#=GS E1BUP9_CHICK/2127-2266  AC E1BUP9.1
#=GS G1MBM9_AILME/2129-2268  AC G1MBM9.1
#=GS G7MEK3_MACMU/2312-2451  AC G7MEK3.1
#=GS H9Z4G9_MACMU/1892-2034  AC H9Z4G9.1
#=GS G1KES2_ANOCA/1773-1915  AC G1KES2.1
#=GS E9Q426_MOUSE/2122-2261  AC E9Q426.1
#=GS F7AGK4_XENTR/1498-1635  AC F7AGK4.1
#=GS G3QIW8_GORGO/2201-2340  AC G3QIW8.1
#=GS Q9QZ84_MOUSE/1607-1746  AC Q9QZ84.1
#=GS D2HFX5_AILME/2310-2449  AC D2HFX5.1
#=GS F6X517_HORSE/2127-2266  AC F6X517.1
#=GS Q155P7_MOUSE/1893-2035  AC Q155P7.1
#=GS F1N1F8_BOVIN/1888-2031  AC F1N1F8.2
#=GS Q9GKN2_RABIT/3-142      AC Q9GKN2.1
#=GS F7A8M3_XENTR/1499-1637  AC F7A8M3.1
#=GS C6GAA1_AERHY/217-346    AC C6GAA1.1
#=GS C4NV61_ECOLX/217-346    AC C4NV61.1
#=GS H0WHX6_OTOGA/1881-2023  AC H0WHX6.1
#=GS H2Z639_CIOSA/491-614    AC H2Z639.1
#=GS Q9GKN4_CANFA/3-142      AC Q9GKN4.1
#=GS Q4RKR8_TETNG/1-143      AC Q4RKR8.1
#=GS H2Q149_PANTR/2131-2270  AC H2Q149.1
#=GS E1C703_CHICK/2134-2273  AC E1C703.1
#=GS G7NUK3_MACFA/2130-2269  AC G7NUK3.1
#=GS G1RW78_NOMLE/2131-2270  AC G1RW78.1
#=GS G3QIW8_GORGO/1781-1923  AC G3QIW8.1
#=GS G1KES2_ANOCA/2011-2150  AC G1KES2.1
#=GS F6X517_HORSE/1889-2031  AC F6X517.1
#=GS C2IBP4_VIBCL/217-346    AC C2IBP4.1
#=GS G9FJQ0_KLEPN/217-346    AC G9FJQ0.1
#=GS CENPF_HUMAN/2409-2548   AC P49454.2
#=GS E1IU41_ECOLX/217-346    AC E1IU41.1
#=GS H2Z641_CIOSA/285-401    AC H2Z641.1
#=GS G0XB14_ECOLX/217-346    AC G0XB14.1
#=GS G3GRF9_CRIGR/2295-2434  AC G3GRF9.1
#=GS F1P3L8_CHICK/857-996    AC F1P3L8.1
#=GS H6URX5_PROST/217-346    AC H6URX5.1
#=GS H2N3Q4_PONAB/2312-2451  AC H2N3Q4.1
#=GS G3UPQ0_MELGA/2069-2208  AC G3UPQ0.1
#=GS F1PRS3_CANFA/2033-2172  AC F1PRS3.1
#=GS F6X517_HORSE/2309-2448  AC F6X517.1
#=GS F6VU99_ORNAN/1377-1514  AC F6VU99.1
#=GS G7MEK3_MACMU/2130-2269  AC G7MEK3.1
#=GS G3X012_SARHA/2287-2369  AC G3X012.1
#=GS H3AGZ6_LATCH/2137-2276  AC H3AGZ6.1
#=GS F1N1F8_BOVIN/2276-2415  AC F1N1F8.2
#=GS E9PT83_RAT/2111-2250    AC E9PT83.1
#=GS F1NYR4_CHICK/872-1011   AC F1NYR4.1
#=GS F1S2Y5_PIG/2095-2234    AC F1S2Y5.1
#=GS F6RLX8_MACMU/2127-2266  AC F6RLX8.1
#=GS F5BQ24_SALDU/217-346    AC F5BQ24.1
#=GS F7EG17_MONDO/1359-1501  AC F7EG17.1
#=GS Q9QZ84_MOUSE/1369-1511  AC Q9QZ84.1
#=GS H2TCK0_TAKRU/58-138     AC H2TCK0.1
#=GS E9Q426_MOUSE/2304-2440  AC E9Q426.1
#=GS G8XD12_KLEPN/217-346    AC G8XD12.1
#=GS G3GRF9_CRIGR/1875-2017  AC G3GRF9.1
#=GS D2HFX5_AILME/2128-2267  AC D2HFX5.1
#=GS Q9QZ84_MOUSE/1789-1925  AC Q9QZ84.1
#=GS G3PUT2_GASAC/2119-2262  AC G3PUT2.1
#=GS G3QIW8_GORGO/2019-2158  AC G3QIW8.1
#=GS G1U7C9_RABIT/2095-2234  AC G1U7C9.1
#=GS Q155P7_MOUSE/2313-2449  AC Q155P7.1
#=GS G1PVZ1_MYOLU/1894-2036  AC G1PVZ1.1
#=GS G3PUT2_GASAC/1881-2023  AC G3PUT2.1
#=GS E9Q3P4_MOUSE/2313-2449  AC E9Q3P4.1
#=GS F7EG17_MONDO/1597-1736  AC F7EG17.1
#=GS F7EG17_MONDO/1807-1923  AC F7EG17.1
#=GS D2YA48_VIBMI/217-345    AC D2YA48.1
#=GS G3GRF9_CRIGR/2113-2252  AC G3GRF9.1
#=GS H0WHX6_OTOGA/2119-2258  AC H0WHX6.1
#=GS A8WGF9_XENTR/1505-1642  AC A8WGF9.1
#=GS F1S2Y5_PIG/1889-2012    AC F1S2Y5.1
#=GS H2TCJ9_TAKRU/1908-2050  AC H2TCJ9.1
#=GS F6RLX8_MACMU/2309-2448  AC F6RLX8.1
#=GS F6RLX8_MACMU/1889-2031  AC F6RLX8.1
#=GS E9UCK9_ECOLX/217-346    AC E9UCK9.1
#=GS G1NB96_MELGA/2110-2249  AC G1NB96.2
#=GS F1PRS3_CANFA/2215-2354  AC F1PRS3.1
#=GS E9Q3P4_MOUSE/1893-2035  AC E9Q3P4.1
#=GS G1MBM9_AILME/2311-2450  AC G1MBM9.1
#=GS Q155P7_MOUSE/2131-2270  AC Q155P7.1
#=GS E9PT83_RAT/1873-2015    AC E9PT83.1
#=GS H2Q149_PANTR/1893-2035  AC H2Q149.1
#=GS H0WHX6_OTOGA/2301-2440  AC H0WHX6.1
#=GS D7YRB4_ECOLX/217-346    AC D7YRB4.1
#=GS G1PVZ1_MYOLU/2298-2439  AC G1PVZ1.1
#=GS H2Z640_CIOSA/214-338    AC H2Z640.1
#=GS G1PVZ1_MYOLU/2125-2264  AC G1PVZ1.1
#=GS Q9GKN4_CANFA/185-324    AC Q9GKN4.1
#=GS H2N3Q4_PONAB/1892-2034  AC H2N3Q4.1
#=GS Q9GKN1_RABIT/3-142      AC Q9GKN1.1
#=GS E7FB11_DANRE/1494-1636  AC E7FB11.1
#=GS G3X012_SARHA/2118-2256  AC G3X012.1
#=GS H9Z4G9_MACMU/2130-2269  AC H9Z4G9.1
#=GS G3TYB2_LOXAF/1740-1882  AC G3TYB2.1
#=GS A4IV62_YERPE/217-346    AC A4IV62.1
#=GS Q9EQN8_MOUSE/185-324    AC Q9EQN8.1
#=GS G5BUR9_HETGA/1804-1936  AC G5BUR9.1
#=GS H9TIX8_SALET/217-346    AC H9TIX8.1
#=GS H0VQV9_CAVPO/2269-2408  AC H0VQV9.1
#=GS F1N1F8_BOVIN/2094-2233  AC F1N1F8.2
#=GS G3S416_GORGO/1868-2010  AC G3S416.1
#=GS D2HFX5_AILME/1892-2032  AC D2HFX5.1
#=GS E9Q426_MOUSE/1884-2026  AC E9Q426.1
#=GS G9UE79_SALMO/217-346    AC G9UE79.1
#=GS G3S416_GORGO/2288-2427  AC G3S416.1
#=GS G3X012_SARHA/2360-2442  AC G3X012.1
#=GS H2Q149_PANTR/2313-2452  AC H2Q149.1
#=GS F1S2Y5_PIG/2277-2416    AC F1S2Y5.1
#=GS H9Z4G9_MACMU/2312-2451  AC H9Z4G9.1
#=GS A0PBP5_PASPI/217-346    AC A0PBP5.1
#=GS Q9GKN3_BOVIN/3-142      AC Q9GKN3.1
#=GS G3TYB2_LOXAF/2153-2292  AC G3TYB2.1
#=GS G3S416_GORGO/2106-2245  AC G3S416.1
#=GS G5BUR9_HETGA/2028-2167  AC G5BUR9.1
#=GS E7FFC1_DANRE/2025-2168  AC E7FFC1.1
#=GS G7MEK3_MACMU/1892-2034  AC G7MEK3.1
#=GS F6WML7_ORNAN/2151-2297  AC F6WML7.1
#=GS CENPF_HUMAN/2227-2366   AC P49454.2
#=GS F6VU99_ORNAN/1615-1761  AC F6VU99.1
#=GS E9PT83_RAT/2293-2431    AC E9PT83.1
#=GS G1MBM9_AILME/1893-2033  AC G1MBM9.1
#=GS G1U7C9_RABIT/1857-1999  AC G1U7C9.1
#=GS E9Q3P4_MOUSE/2131-2270  AC E9Q3P4.1
#=GS F6WML7_ORNAN/1913-2051  AC F6WML7.1
#=GS H2TCJ9_TAKRU/2146-2283  AC H2TCJ9.1
#=GS A4IVQ2_SALNS/217-346    AC A4IVQ2.1
#=GS F2Z852_SALTM/217-346    AC F2Z852.1
#=GS G1U7C9_RABIT/2277-2416  AC G1U7C9.1
#=GS G1RW78_NOMLE/2313-2452  AC G1RW78.1
#=GS Q98940_CHICK/857-996    AC Q98940.1
#=GS Q9EQN8_MOUSE/3-142      AC Q9EQN8.1
#=GS G7NUK3_MACFA/2312-2451  AC G7NUK3.1
#=GS H0VQV9_CAVPO/2087-2226  AC H0VQV9.1
#=GS E7FFC1_DANRE/1787-1929  AC E7FFC1.1
#=GS F7A8M3_XENTR/1732-1864  AC F7A8M3.1
F1PRS3_CANFA/1795-1937             ..........WRERFLDMENELKRIKSEKGSIEH.HALSVEAELETVQTEKLYLVKDNENKQKAITC....LEEELSVVTSERNQLHGQLDTLS.......KEK..KELDLMSEKMKQKIQELESRE...DE...CLhpSDMA...GAEVK..dKMQLVQRLSSDVTQLLEDNTRLQ-e................
G7NUK3_MACFA/1892-2034             ..........WKERFLDVENELSSIRSEKANIEH.QALSLEADLEIVQTEKLCLEKDNENNQKVIVC....LEEELSVVTSERNQLRGELDTMS.......KKI..MELDQLSEKMKEKTQELESHR...SE...YL..HCIQ...VAEAKvkeKTELLQTLSSDVSELLKDKTHLQE.................
Q90YL2_CHICK/872-1011              ..........DERKTRHIAEKLKENERKSDALLD.KVERLERELEMSEENLEDAVVQLATAKAEAET....FITEKEEMAEKLKCLQSQLDDLT.......SQK..ECLAKDSKEKQERILELESSN...LT...TA..KLLE...EKEEE...KMQIKDEFENAVLLLKSELKGMSE.................
G5BUR9_HETGA/2210-2349             ..........DREKQLHVLQQLKESECHADLLKG.SVESLERELELSGRSQEHAVREAKDSRAEVET....LKAEIQQIAQNLRDLEVDLVNTK.......SEK..ENLTKGLQEEQARVSELEILN...SS...LE..NLLQ...EKEHQ...NVQIKEESEVAVEMLQAQLKVLDE.................
H2N3Q4_PONAB/2130-2269             ..........DEKKQLHVAEKLKERERENDSLKD.KVENLERELQMSEENQELVILDAENSKAEVET....LKTQIEEMARSLKVFELDLVTLR.......SEK..ENLTKQIQEKQGQVSELDKLL...SS...FK..SLLE...EKEQA...EIQIKEESKTAVEMLQNQLKELNE.................
A4IUK0_YERRU/217-346               .......qkg---KSIEQTEKLRAAQEQNTSLKE.QLENVQAKLAQSQDSLATAKAHGESAERECQR....LSGEVEKLDAKLSSAEAEARALV.......QDK..GMMAGQLQEKDQQAKSLEQRL...ND...AL..TKIS...GLEQE...LVKA--------------------gkggkkkeen.......
G1RW78_NOMLE/1893-2035             ..........WKERFLDVENELRRIRSEKANIEH.QALSLEADLEVVQTEKVCLEKDNENKQKVIVC....LEEELSVVTSERNQLRGELDTMS.......KKT..MELDQLSEKMKEKTQELESHQ...SE...CL..HCIQ...VAEAEvkeKTELLQTLSSDVSELLKDKTHLQE.................
H3AGZ6_LATCH/1901-2043             ..........WNEKYLEVENELKRTRSEKANLEK.HILSMEADIEEMQIAKTSLEKEAANSSKCISR....LGEQLSVATADKNQLSQELESSR.......EIQ..EELEQISQNLKEKLEQLASDK...VN...YT..EFIK...VLEAEnkkLTKQLEITKFDVEKLSKERNSI--le...............
Q4RKR8_TETNG/265-370               ..........DERKKKKMGELLKAAQTKSDSLQG.RIDALVREREDVEQSLEEAVLQAETSKAELEE....EQRKVSQLTSGLARLAKERDSAL.......SKM..SLWMKTCKQLQQ---------...--...--..----...-----...------------------------ekeamltstgts.....
C0GJU0_9FIRM/650-748               .......lpe-------ICDKWKEVAATGETVADeRVFALERELRNKEEYLQTVIEELETSNEELQS....TNEEFQSVNEELETSKEELQSLN.......EEL..MIVNAELQKK---IDELS---...--...--..----...-----...------------------------csnnd............
C4NVP0_SALCE/217-346               .......qkg---KSIEQTEKLRAAQEQKTSLKE.QLENVQAKLAQSQDSLATAKAHGESAERECQR....LSGEVEKLDAKLSSAEAEARALV.......QDK..GMMAGQLQEKDQQAKSLEQRL...ND...AL..TKIS...GLEQE...LAKA--------------------gkggkkkeen.......
CENPF_HUMAN/1989-2131              ..........WKERFLDVENELSRIRSEKASIEH.EALYLEADLEVVQTEKLCLEKDNENKQKVIVC....LEEELSVVTSERNQLRGELDTMS.......KKT..TALDQLSEKMKEKTQELESHQ...SE...CL..HCIQ...VAEAEvkeKTELLQTLSSDVSELLKDKTHLQE.................
G3TYB2_LOXAF/1971-2110             ..........DEKRQLHVLEKLKESERRSDSLKD.KVENLERELQMSEENQELVILDAENSKAEVET....LKEKIEEMAEMLKGLEFDLVTVR.......SEK..ENLTEQLQEKQSQVLELEPLL...SS...LK..TLIK...EKEQE...KIQMKEECKAAGELLQAQLKELNE.................
E1BUP9_CHICK/2127-2266             ..........DERKKRHIAEKLKENERKSDALLD.KVERLERELEMSEENLEDAVVQLETAKAEAET....FITEKEEMAEKLKCLQSQIDDLT.......SQK..ECLAKDSKEKQERILELESSN...LT...TA..KLLE...EKEEE...KMQIKDEFENAVLLLKSELKGMSE.................
G1MBM9_AILME/2129-2268             ..........DDKKQLHVLEKLRESERKADSLQD.KVENLERELQMSEENQELVILDAENSKAEVEA....LKTQMELMTKNLRDLELDLGTIR.......FEK..ENLVKQLQDKQGQVSELDTLL...SS...LK..GRLE...EEEQG...KIEMREESKAALEMLQTQLKELNE.................
G7MEK3_MACMU/2312-2451             ..........DEKKQLCVLEQLKESEHHADLLKS.RVENLERELEIAGKNQEHAALEAENSKGEVET....LKAKIEGMTQSLRDLELDLATVR.......SEK..ENLTNKLQKEQERISELEIIN...SS...FE..NILR...EKEQE...KVQMKEKSNTAMEMLQTQLKELHE.................
H9Z4G9_MACMU/1892-2034             ..........WKERFLDVENELSSIRSEKANIEH.QALSLEADLEIVQTEKLCLEKDNENNQKVIVC....LEEELSVVTSERNQLRGELDTMS.......KKI..MELDQLSEKMKEKTQELESHR...SE...YL..HCIQ...VAEAKvkeKTELLQTLSSDVSELLKDKTHLQE.................
G1KES2_ANOCA/1773-1915             ..........WTEKLLEAENELRRIKSEKANVEN.HALFMEADIEELQAKNEQLEREKENELKTIFG....LQDQLCMITAERNQFTQDLSALS.......KDK..EELDQKCQKMQETIKELESRR...VD...ST..EFIR...ILEAEaktQAKLLQAAKAASSQLSTEKEGLT-l................
E9Q426_MOUSE/2122-2261             ..........DEKKHLSAVAKLKESQRESDSLKD.TVETLERELERSEENQELAILDSENLKAEVET....LKAQKDEMTKSLRIFELDLVTVR.......TER..ENLAKQLQEKQSRVSELDERC...SS...LR..RLLE...EKEQA...RVQMEEDSKSAMLMLQMQLKELRE.................
F7AGK4_XENTR/1498-1635             ........ke---QYLETENEVRRVKSERANMEN.HALSLEIDLDTIQAKYQQLQEENEEYRRSAAT....LQDRLSVVVAEKNQIDQELENLT.......EEK..DELEQMCQKLKERVEDLELNK...VH...NR..NLIK...ILETElrsLKAELQGAKASLEQLSAEK-----d................
G3QIW8_GORGO/2201-2340             ..........DEKKQLCVLQQLKESEHHADLLKG.RVENLERELEIARTNQEHAALEAENSKGEVET....LKAKIEGMTQSLRDLELDLVTIR.......SEK..ENLTNELEKEQKRISELEIIN...SS...FE..NILQ...EKEQE...KVQMKEKSSTAMEMLQTQLKELNE.................
Q9QZ84_MOUSE/1607-1746             ..........DEKKHLSAVAKLKESQRESDSLKD.TVETLERELERSEENQELAILDSENLKAEVET....LKAQKDEMTKSLRIFELDLVTVR.......TER..ENLAKQLQEKQSRVSELDERC...SS...LR..RLLE...EKEQA...RVQMEEDSKSAMLMLQMQLKELRE.................
D2HFX5_AILME/2310-2449             ..........DEKEQLQVLGKLTESEHHVDLLKD.RVENLERELERSRENRERVILEAENSKAEVGT....LKAKIEEMAQTLRDLELDLVHIR.......SEK..ENVIKELQKEQGRVSELEILN...SS...FE..NLLQ...EKEQE...KVQIREESKIAVETLQTQLKELNE.................
F6X517_HORSE/2127-2266             ..........DEKKQLHALEKLKESERKNDSLQD.KVENLERELQMSEENQELVILDAENCRAEAET....LKTQIELMTESLKVLEGDLTTVR.......SEK..ENLMKELQEKQGQVSELDTLV...SS...FK..NLLE...EKEQE...KIQMKEQSKAAVEMLQTELKELNE.................
Q155P7_MOUSE/1893-2035             .........y-KEKFLDMERELTRIKSEKANIEH.HILSVETNLEVVQAEKLCLERDTESKQKVIID....LKEELFTVISERNRLREELDNVS.......KES..KALDQMSKKMKEKIEELESHQ...RE...SL..RHIG...AVESEvkdKADLIQTLSFNVGELTKDKAHLQE.................
F1N1F8_BOVIN/1888-2031             ..........WREKCLQVENELQRIQSEKDSMEH.HALSAEASLEAVQTEKLYLEKDNENKQTVITC....LEEGLSVVTSERDQLRGELDTLS.......KEN..QELDQMSEKMKEKIRELESHQ...SEclhLQ..EWLQ...SLEKDsqaLSLVRSELENQIEQLNKEKDS---l................
Q9GKN2_RABIT/3-142                 ..........DEKKQLRVTEKLKESERESDLLKD.KVENLERELQMSEENQELVILDAENSKAEVET....LKAKIEEMTESLKALESDLVIVR.......CDK..DSLTKQLQEKQGQVSELDNLL...SS...FK..SLLA...EKEQV...EIQIKEESETKMEMLQTQLKELNE.................
F7A8M3_XENTR/1499-1637             ........lk--EQYLETENEVRRVKSERANMEN.HALSLEIDLDTIQAKYQQLQEENEEYRRSAAT....LQDRLSVVVAEKNQIDQELENLT.......EEK..DELEQMCQKLKERVEDLELNK...VH...NR..NLIK...ILETElrsLKAELQGAKASLEQLSAEK-----d................
C6GAA1_AERHY/217-346               .......qkg---KSIEQTEKLRAAQEQSTSLKE.QLENAQAKLAQSQDSLATAKAHGESAERECQR....LSGEVEKLETKLSSAEAEARSLV.......QDK..GMIAGQLQEKDQQAKSLEQRL...TD...AL..TKIS...GLEQE...RIKAG-------------------ggekkkeen........
C4NV61_ECOLX/217-346               .......qkg---KSIEQTEKLRAAQEQKTSLKE.QLENVQAKLAQSQDSLATAKAHGESAERECQR....LSGEVEKLDAKLSSAEAEARALV.......QDK..GMMAGQLQEKDQQAKSLEQRL...ND...AL..TKIS...GLEQE...LAKA--------------------gkggkkkeen.......
H0WHX6_OTOGA/1881-2023             ..........WKERFLGVENELNRIKSEKASMEH.HVLSVKADLEIVQTEKLNLEKDNENKQKVIVS....LEEELSVVTSERNRLHGELDIVS.......KEN..KELDRLSEMMKEKTQELEAHQ...GD...CL..HQMQ...VVEAEvknKTEQLQTLSSDVSQLLKDKAHLQE.................
H2Z639_CIOSA/491-614               .......lea----------KLDRAGDDLASSER.EVRSLRRQLDATQTDLAEASRAKETALRENRR....MQDDLSTLTRENQDINMELDDVM.......RDR..DDLKNKVQDHVGRISSLESSV...SS...KD..RELH...DVLDQ...YRKVT-------------------serdsaesry.......
Q9GKN4_CANFA/3-142                 ..........DEKKQLHVLEKLRESERKADALQD.KIENLERELQMSEENQELVILDAENSKAEVET....LKTQMELTTKSLKDLESDLVTVR.......FEK..ENLIKQLQDKQGQVSELDTLL...SS...FK..GQLE...EKERE...KIEMKEESRAALEMLRTQLKELNE.................
Q4RKR8_TETNG/1-143                 ..........WDEKFLQQESELKRVRSEKANLEQ.HILGMESELESLQEERSRLGAELETQRKVCSG....LEQKMGALDTETSRLRCELVSCS.......EER..DHLNQSLGHWRNKADGLEKTN...GD...TR..NLVS...ILEDDiraGRKEYEALKTSTEKLASEKQQLLE.................
H2Q149_PANTR/2131-2270             ..........DEKKQLHVAEELKERERENDSLKD.KVENLERELQMSEENQELVILDAENSKAEVET....LKTQIEEMARSLKVFELDLVTLR.......SEK..ENLTKQIQEKQGQLSELDKLL...SS...FK..SLLE...EKEQA...EIQIKEESKTAVEMLQNQLKELNE.................
E1C703_CHICK/2134-2273             ..........DERKKRHIAEKLKENERKSDALLD.KVERLERELEMSEENLEDAVVQLETAKAEAET....FITEKEEMAEKLKCLQSQIDDLT.......SQK..ECLAKDSKEKQERILELESSN...LT...TA..KLLE...EKEEE...KMQIKDEFENAVLLLKSELKGMSE.................
G7NUK3_MACFA/2130-2269             ..........DERKQLHVAEKLKERERENDSLKD.KVENLERELQMSEENQELVILDAENSKAEVET....LKTQIEEMARSLKVFELDLVTLR.......SEK..ENLTKQIQDKQGQVSELDKLL...AS...VK..SLLE...EKEQA...EIQIKEESKTAVEMLQNQLKELNE.................
G1RW78_NOMLE/2131-2270             ..........DEKKQLLVAEKLKERERENDSLKD.KVENLERELQMSEENQELVILDAENSKAEVET....LKTQIEEMARSLKVFKLDLVTLR.......SEK..ENLTKQIQEKQGQVSELDKLL...SS...FK..SLLE...EKEQA...EIQIKEESKTAVEMLQNQLKELNE.................
G3QIW8_GORGO/1781-1923             ..........WKERFLDVENELSRIRSEKANIEH.QALYLEADLEVVQTEKLCLEKDNENKQKVIVC....LEEELSVVTSERNQLRGELDTMS.......KKT..MELDQLSEKMKEKTQELESHQ...SE...CL..HCIQ...VAEAEvkeKTELLQTLSSDVSELLKDKTHLQE.................
G1KES2_ANOCA/2011-2150             ..........DEKSKHRLAEKWKETQRKADSLVD.KIESLERELQMSEENLEGAILQAEVAKEEAEA....ANAEIENMRVTLQRLEHEISALK.......SEK..VCLESMLEEKQVKVSSLESSH...VV...LL..KQVK...EEEQK...MVKIRGEYERELLSMQSQLNQAHE.................
F6X517_HORSE/1889-2031             ..........WRERFFDAENELKRIKSEKSSIEL.HALSVEADLERVQTEKLYLEKDNENKQNVITC....LEEELSVVTSERNRLHGELDTLS.......KEN..KELDQASEKMKEKVLELESRQ...GE...CL..QHLD...VVGAEvreKTQLLQTLSSEVSELLEDKGHLQE.................
C2IBP4_VIBCL/217-346               .......qkg---KSIEQTEKLRAAQEQKTSLKE.QLENVQAKLAQSQDSLATAKAHGESAERECQR....LSGEVEKLDAKLSSAEAEARALV.......QDK..GMMAGQLQEKDQQAKSLEQRL...ND...AL..TKIS...GLEQE...LAKA--------------------gkggkkkeen.......
G9FJQ0_KLEPN/217-346               .......qkg---KSIEQTEKLRAAQEQKTSLKE.QLENVQAKLAQSQDSLATAKAHGESAERECQR....LSGEVEKLDAKLSSAEAEARALV.......QDK..GMMAGQLQEKDQQAKSLEQRL...ND...AL..TKIS...GLEQE...LAKA--------------------gkggkkkeen.......
CENPF_HUMAN/2409-2548              ..........DEKKQLCVLQQLKESEHHADLLKG.RVENLERELEIARTNQEHAALEAENSKGEVET....LKAKIEGMTQSLRGLELDVVTIR.......SEK..ENLTNELQKEQERISELEIIN...SS...FE..NILQ...EKEQE...KVQMKEKSSTAMEMLQTQLKELNE.................
E1IU41_ECOLX/217-346               .......qkg---KSIEQTEKLRAAQEQKTSLKE.QLENVQAKLAQSQDSLATAKAHGESAERECQR....LSGEVEKLDAKLSSAEAEARALV.......QDK..GMMAGQLQEKDQQAKSLEQRL...ND...AL..TKIS...GLEQE...LAKA--------------------gkggkkkeen.......
H2Z641_CIOSA/285-401               .ragddlass----------------------ER.EVRSLRRQLDATQTDLAEASRAKETALRENRR....MQDDLSTLTRENQDINMELDDVM.......RDR..DDLKNKVQDHVGRISSLESSV...SS...KD..RELH...DVLDQ...YRKVT-------------------serdsaesr........
G0XB14_ECOLX/217-346               .......qkg---KSIEQTEKLRAAQEQKTSLKE.QLENVQAKLAQSQDSLATAKAHGESAERECQR....LSGEVEKLDAKLSSAEAEARALV.......QDK..GMMAGQLQEKDQQAKSLEQRL...ND...AL..TKIS...GLEQE...LAKA--------------------gkggkkkeen.......
G3GRF9_CRIGR/2295-2434             .........g-EKEQHCLLGQLRESKHYADVLKD.RVENLEQELKLSEANREHVTLKAESSKAEIQT....LKSEIQGMVQNIQDLELELTNTR.......SEN..ENLMKGLKQEQKRVSELETKN...SS...IE..NLLK...EKEQE...KVQMEEESKITMERLQTQLRELNE.................
F1P3L8_CHICK/857-996               ..........DERKKRHIAEKLKENERKSDALLD.KVERLERELEMSEENLEDAVVQLETAKAEAET....FITEKEEMAEKLKCLQSQIDDLT.......SQK..ECLAKDSKEKQERILELESSN...LT...TA..KLLE...EKEEE...KMQIKDEFENAVLLLKSELKGMSE.................
H6URX5_PROST/217-346               .......qkg---KSIEQTEKLRAAQEQKTSLKE.QLENVQAKLAQSQDSLATAKAHGESAERECQR....LSGEVEKLDAKLSSAEAEARALV.......QDK..GMMAGQLQEKDQQAKSLEQRL...ND...AL..TKIS...GLEQE...LAKA--------------------gkggkkkeen.......
H2N3Q4_PONAB/2312-2451             ..........DEKKQLCVLEQLKESEHHADLLKG.RVENLERELEIARTNQEHAALEAESSKGEVDT....LKAKIEGMTQSLRDLELDLVTIR.......SEK..ENLTNELQKEQERISELEIIN...SS...FE..NILQ...EKEQE...KVQMKEKSSTVMEMLQTQLKELNE.................
G3UPQ0_MELGA/2069-2208             ..........DERKKHYIAEKLKENERKSDALLD.KVERLERELEMSEENLEDAVVRLETAKAEAET....LTAEKEEMAEKLKRLQSQINDLT.......SQK..ERLAKDSKDKQERILELESSN...LT...TA..KLIE...EKEKE...KMQIKDEFENAVLLLKTELKGMSE.................
F1PRS3_CANFA/2033-2172             ..........DEKKQLHVLEKLRESERKADALQD.KIENLERELQMSEENQELVILDAENSKAEVET....LKTQMELTTKSLKDLESDLVTVR.......FEK..ENLIKQLQDKQGQVSELDTLL...SS...FK..GQLE...EKERE...KIEMKEESRAALEMLRTQLKELNE.................
F6X517_HORSE/2309-2448             ..........DEKKQLHTLGELKESRHHVDLLKD.RVENLERELEISKEKQERVRLEAENSKAEVVT....LKVKIEEMAQSLRDLELDLGNIR.......SEK..ENLTKELQKEQGRVSELEVLN...CS...FE..NLLQ...EKEQE...KVEMKEESKIAVEMLQTQLKELNE.................
F6VU99_ORNAN/1377-1514             ..........WKEKCLEIEKELKRVKSEKANVEN.HALTMESDFEELQTQRRNLENDNENKRETITS....LQEQLSVITSERNQLTEELNALS.......EEK..AIVGQDCEKLKEKIKDFETSE...EE...SI..RHIQ...RVESEvkeKT----------------------vlvqalssdinhlsrdk
G7MEK3_MACMU/2130-2269             ..........DERKQLHVAEKLKERERENDSLKD.KVENLERELQMSEENQELVILDAENSKAEVET....LKTQIEEMARSLKVFELDLVTLR.......SEK..ENLTKQIQDKQGQVSELDKLL...AS...VK..SLLE...EKEQA...EIQIKEESKTAVEMLQNQLKELNE.................
G3X012_SARHA/2287-2369             ..........---------------------LTQ.TIKYLESELAALREEKESISNEVLKEKQY---....RVCELEELTKSLKCLEIEVVSLR.......SEK..ESILKELQKKQSEVSELEELT...KT...L-..----...-----...------------------------r................
H3AGZ6_LATCH/2137-2276             ..........DEKKRHHEAEKLKASERKADSFQD.KVEKLQRELQMSEESLEGMVLEAETVKEEMEK....LVTVKQEISKKLQILETEVNTLS.......SER..DLLDKELQQKQLKISELEGSC...MD...IT..NLLK...KVEEE...KLQVMQEHVVSQKALKSELMELNE.................
F1N1F8_BOVIN/2276-2415             ..........DKKKQLQILEKLKESEHQADFLKD.TVENLERELKLSGENQEHVTLEAEKSKAEVET....LKATVEKMDQNLRGLQLDLVNIR.......SEK..EDLTKELQKEQSRVSELETLN...SS...FE..NLLR...EKEQE...KVQMKEESKAAVEMLQTQLKELNE.................
E9PT83_RAT/2111-2250               ..........DEKKHLSAVAKLKESQRESDSLKD.KVENLERELEMSEENQELAILDSENLKAEVET....LKAQMDEMAKSLRVFELDLVNVR.......SER..ENLAKQLQEKQSRVSELDELC...SS...LR..SLSE...EKEQA...RVQMERDSKSAMLMLQTQLKELWE.................
F1NYR4_CHICK/872-1011              ..........DERKKRHIAEKLKENERKSDALLD.KVERLERELEMSEENLEDAVVQLETAKAEAET....FITEKEEMAEKLKCLQSQIDDLT.......SQK..ECLAKDSKEKQERILELESSN...LT...TA..KLLE...EKEEE...KMQIKDEFENAVLLLKSELKGMSE.................
F1S2Y5_PIG/2095-2234               ..........DEKKQLHVSEKLRESERRNDALQD.KVENLERELQMAEENQELVILDAENSKAEVDT....LKTQIELMTESLKTLELDLVTTQ.......SEK..ETLTKQLQEKQGQVSELDTLL...SS...LK..NLLE...GKEQE...KIQMKEESKAAVEMLQTQLKELTE.................
F6RLX8_MACMU/2127-2266             ..........DERKQLHVAEKLKERERENDSLKD.KVENLERELQMSEENQELVILDAENSKAEVET....LKTQIEEMARSLKVFELDLVTLR.......SEK..ENLTKQIQDKQGQVSELDKLL...AS...VK..SLLE...EKEQA...EIQIKEESKTAVEMLQNQLKELNE.................
F5BQ24_SALDU/217-346               .......qkg---KSIEQTEKLRAAQEQKTSLKE.QLENVQAKLAQSQDSLATAKAHGESAERECQR....LSGEVEKLDAKLSSAEAEARALV.......QDK..GMMAGQLQEKDQQAKSLEQRL...ND...AL..TKIS...GLEQE...LAKA--------------------gkggkkkeen.......
F7EG17_MONDO/1359-1501             ..........WKEQFLEIENEFKKVKSEKTSIEN.HAFSLEADLESLQTKNLCLEKDNENKQKVISN....LEEQLSLIISERNQLNGELDILL.......KSK..LKMEEICDELKERVKVLESSQ...RK...SL..QHIQ...VVESEvrdKTQLLQTMSSDVNQLLKDKDYLQE.................
Q9QZ84_MOUSE/1369-1511             .........y-KEKFLDMERELTRIKSEKANIEH.HILSVETNLEVVQAEKLCLERDTESKQKVIID....LKEELFTVISERNRLREELDNVS.......KES..KALDQMSKKMKEKIEELESHQ...RE...SL..RHIG...AVESEvkdKADLIQTLSFNVGELTKDKAHLQE.................
H2TCK0_TAKRU/58-138                .......ktl---KSEDNESELKRVRSEKSNLEQ.HILGMESDLENLQEERTKLKTEVETQRKVCSG....MEQEIDTLRTELDKITED-----.......---..---------------------...--...--..----...-----...------------------------hlsahqn..........
E9Q426_MOUSE/2304-2440             ..........DEKKHQNILEQLKESKHHADLLKD.RVENLEQELILSEKN---MIFQAEKSKAEIQT....LKSEIQRMAQNLQDLQLELISTR.......SEN..ENLMKELKKEQERVSDLETIN...SS...IE..NLLK...DKEQE...KVQMKEEAKITVEMLQTQLKELNE.................
G8XD12_KLEPN/217-346               .......qkg---KSIEQTEKLRAAQEQKTSLKE.QLENVQAKLAQSQDSLATAKAHGESAERECQR....LSGEVEKLDAKLSSAEAEARALV.......QDK..GMMAGQLQEKDQQAKSLEQRL...ND...AL..TKIS...GLEQE...LAKA--------------------gkggkkkeen.......
G3GRF9_CRIGR/1875-2017             ..........WKEKFLDVEKELIRIQSEKANLEH.LILSVEADLKVVQAEKLHLERDTESKQKVIVD....LKEELFVVISERNRLCGELDTVS.......EER..KALDQMSKKMKEKVEELESHQ...SE...SL..RHIE...VVEAEvkdKAELLQTLSFNVSELTKDKAHLQE.................
D2HFX5_AILME/2128-2267             ..........DDKKQLHVLEKLRESERKADSLQD.KVENLERELQMSEENQELVILDAENSKAEVEA....LKTQMELMTKNLRDLELDLGTIR.......FEK..ENLVKQLQDKQGQVSELDTLL...SS...LK..GRLE...EEEQG...KIEMREESKAALEMLQTQLKELNE.................
Q9QZ84_MOUSE/1789-1925             ..........DEKKHQNILEQLKESKHHADLLKD.RVENLEQELILSEKN---MIFQAEKSKAEIQT....LKSEIQRMAQNLQDLQLELISTR.......SEN..ENLIKELKKEQERVSDLETIN...PS...IE..NLLK...DKEQE...KVQMKEEAKITVEMLQTQLKELNE.................
G3PUT2_GASAC/2119-2262             ..........DERKKKKMGELLKAAQRKSDSLHD.RIEALEREKEDQEQSLEEAVLQAETAKAELEEekrkVEEEKRQLREKLSELSAKLENLR.......SEK..DQMERELEPKNREIEDLKAAK...ED...LE..RGLE...RAEVD...RREEEERQKHRVEELTKGMREEAE.................
G3QIW8_GORGO/2019-2158             ..........DEKRQLHVAEKLKERERENDSLKD.KVENLERELQMSEENQELVILDAENSKAEVET....LKTQIEEMARSLKVFELDLVTLR.......SEK..ENLTKQIQEKQGQLSELDKFL...SS...FK..SLLE...EKEQA...EIQIKEESKTAVEMLQNQLKELNE.................
G1U7C9_RABIT/2095-2234             ..........DENKHLRVTEKLKESERESDLLKD.KVENLERELQMSEENQELVILDAENSKAEVET....LKAKIEEMTESLKALESDLVIVR.......SDK..DSLTKQLQEKQGQVSELDNLL...SS...FK..SLLA...EKEQV...EIQIKEESETKMEMLQTQLKELNE.................
Q155P7_MOUSE/2313-2449             ..........DEKKHQNILEQLKESKHHADLLKD.RVENLEQELILSEKN---MIFQAEKSKAEIQT....LKSEIQRMAQNLQDLQLELISTR.......SEN..ENLIKELKKEQERVSDLETIN...PS...IE..NLLK...DKEQE...KVQMKEEAKITVEMLQTQLKELNE.................
G1PVZ1_MYOLU/1894-2036             ..........WRERFLEVENELQRIKLEKGSIEH.HAHSVEADIERVQTEKLQLEKDYESKQQVISH....LEEELSVVTSERNRLHGELDTLS.......KEN..KELDLMSEKMKEKIRELESHQ...EE...CL..QHIE...VVGDElkdKTQLLQNLSSDNARLQEQLQSLE-k................
G3PUT2_GASAC/1881-2023             ..........WDEKFLQQESELKRVRSEKANLEQ.HILGMESELETLQGEKSKLGSAMETQRKACSS....MEQQIETLRTETTQLRSELVLCT.......EER..DELNQSLGQSREKVHSLEKSN...CD...TR..NLIS...ILEDDiraDKKEYDSLQSSMQELKIERQQLLE.................
E9Q3P4_MOUSE/2313-2449             ..........DEKKHQNILEQLKESKHHADLLKD.RVENLEQELILSEKN---MIFQAEKSKAEIQT....LKSEIQRMAQNLQDLQLELISTR.......SEN..ENLMKELKKEQERVSDLETIN...SS...IE..NLLK...DKEQE...KVQMKEEAKITVEMLQTQLKELNE.................
F7EG17_MONDO/1597-1736             ..........DEKKKHHVLEKLKESERKADSFKD.KIEALERELLMSEENQEAIILDAENAKSELET....LKTQMEELTKGLKRSELELSALRse...niSEK..ENVLKELHENQSKVSEFLKYV...ES...IV..SLKS...EKENM...SIELQENHNYLLEELTKTLK----.................
F7EG17_MONDO/1807-1923             ...liqnlkc------------------------.----LEKEV--VLQEKQSQVCELEELTRSLNS....LESESEKLTKNLKCLETELVSLS.......SEK..QNVLKELQEKQAQVEELKMLN...VS...FE..SLLE...KKEEE...KRKLKEESQHTTELLQKQLNDLNE.................
D2YA48_VIBMI/217-345               .......qkg---KSIEQTEKLRAAQEQNTSLKE.QLENVQAKLAQSQDSLATAKAHGESAERECQR....LSGEVEKLDTKLSSAEAEARALV.......QDK..GMMAGQLQEKDQQAKSLEQRL...ND...AL..TKIS...GLEQE...LVKA--------------------gkggkkked........
G3GRF9_CRIGR/2113-2252             ..........DEKKHFSTEEKLKESQRENDSLKD.KVENLERELEMSEEHQELVILDAENSKAEVET....LKAQMDEMAKNLSVFELDLVTVR.......SER..ENLTRQLQDKQSRVSELDELC...SS...FR..SLLE...EKEKA...RVQMEEDSNSAVLMLQTQLQEFSE.................
H0WHX6_OTOGA/2119-2258             ..........DEKKQLHVAEKLKENELENDLLKD.KVESLERELQMSEENQELVIVDAENLKAEIET....LKSQVEEMAESLKVLELDLDMVR.......SEK..ENLTKELQEKQNQVLELDKLH...SS...YQ..SLLE...KKEQV...TIQIKEASKTVAEMLQNQLKELNE.................
A8WGF9_XENTR/1505-1642             ........ke---QYLETENEVRRVKSERANMEN.HALSLEIDLDTIQAKYQQLQEENEEYRRSAAT....LQDRLSVVVAEKNQIDQELENLT.......EEK..DELEQMCQKLKERVEDLELNK...VH...NR..NLIK...ILETElrsLKAELQGAKASLEQLSAEK-----d................
F1S2Y5_PIG/1889-2012               ..........WGERYFDMNNELQRIKSEKGSTEH.HALSAEADLEVVQTEKLYLEKDNENKQKVITC....LEEELSVVTRERDRLREDLDTLS.......KEN..KELDQLSEKMKEKIGELESLQgerLH...LQ..EQLQ...RLEED...S-----------------------qals.............
H2TCJ9_TAKRU/1908-2050             ..........WDDKFLQQESELKRVRSEKSNLEQ.HILGMESDLENLQEERTKLKTEVETQRKVCSG....MEQEIDTLRTELTQLRAELVSCS.......EER..DDLNQSLGQWRNKVDTLERTN...CD...TR..NLIS...ILEDDirtGRREHKVLKTSIEELASEKQQLLE.................
F6RLX8_MACMU/2309-2448             ..........DEKKQLCVLEQLKESEHHADLLKS.RVENLERELEIAGKNQEHAALEAENSKGEVET....LKAKIEGMTQSLRDLELDLATVR.......SEK..ENLTNKLQKEQERISELEIIN...SS...FE..NILR...EKEQE...KVQMKEKSNTAMEMLQTQLKELHE.................
F6RLX8_MACMU/1889-2031             ..........WKERFLDVENELSSIRSEKANIEH.QALSLEADLEIVQTEKLCLEKDNENNQKVIVC....LEEELSVVTSERNQLRGELDTMS.......KKI..MELDQLSEKMKEKTQELESHR...SE...YL..HCIQ...VAEAKvkeKTELLQTLSSDVSELLKDKTHLQE.................
E9UCK9_ECOLX/217-346               .......qkg---KSIEQTEKLRAAQEQKTSLKE.QLENVQAKLAQSQDSLATAKAHGESAERECQR....LSGEVEKLDAKLSSAEAEARALV.......QDK..GMMAGQLQEKDQQAKSLEQRL...ND...AL..TKIS...GLEQE...LAKA--------------------gkggkkkeen.......
G1NB96_MELGA/2110-2249             ..........DERKKHYIAEKLKENERKSDALLD.KVERLERELEMSEENLEDAVVRLETAKAEAET....LTAEKEEMAEKLKRLQSQINDLT.......SQK..ERLAKDSKDKQERILELESSN...LT...TA..KLIE...EKEKE...KMQIKDEFENAVLLLKTELKGMSE.................
F1PRS3_CANFA/2215-2354             ..........DEKEQLRVLGKLKETEHQASLLKD.RVESLERELEISGKNQECVVLEAENSKAEVGT....LKVKIEEMAQNLRDLELDLVHIR.......SEK..ENMIKELQKEQERVSELELLN...SS...FE..NLLQ...EKEQE...KVQMSEESKTAVGMLQTQLKELNE.................
E9Q3P4_MOUSE/1893-2035             .........y-KEKFLDMERELTRIKSEKANIEH.HILSVETNLEVVQAEKLCLERDTESKQKVIID....LKEELFTVISERNRLREELDNVS.......KES..KALDQMSKKMKEKIEELESHQ...RE...SL..RHIG...AVESEvkdKADLIQTLSFNVGELTKDKAHLQE.................
G1MBM9_AILME/2311-2450             ..........DEKEQLQVLGKLTESEHHVDLLKD.RVENLERELERSRENRERVILEAENSKAEVGT....LKAKIEEMAQTLRDLELDLVHIR.......SEK..ENVIKELQKEQGRVSELEILN...SS...FE..NLLQ...EKEQE...KVQIREESKIAVETLQTQLKELNE.................
Q155P7_MOUSE/2131-2270             ..........DEKKHLSAVAKLKESQRESDSLKD.TVETLERELERSEENQELAILDSENLKAEVET....LKAQKDEMTKSLRIFELDLVTVR.......TER..ENLAKQLQEKQSRVSELDERC...SS...LR..RLLE...EKEQA...RVQMEEDSKSAMLMLQMQLKELRE.................
E9PT83_RAT/1873-2015               .........y-KEKFLDMERELTRIKSEKANIEH.HIVSVKANLEVVQAEKLCLERDTESKQKVIVD....LKGELFTVISERNRLREELDNVS.......KES..KALDQMSKKMKEKIEELESHQ...RE...SL..HHIG...AVESEvkdKAELIQTLSFSVDELTKDKAHLQE.................
H2Q149_PANTR/1893-2035             ..........WKERFLDVENELSRIRSEKANIEH.QALYLEADLEIVQTEKLCLEKDNENKQKVIVC....LEEELSVVTSERNQLRGELDTMS.......KKT..MELDQLSEKMKEKTRELESHQ...SE...CL..HCIQ...VAEAEvkeKTELLQTLSSDVSELLKDKTHLQE.................
H0WHX6_OTOGA/2301-2440             ..........DGKKQLHVLEQLKESKHHADFLKG.RAENLERELEIVGKNQEHVILEAENAKAEVET....LKGKIEGMASNLRDLELDLVNIK.......SEK..ENLTKELQKEQERVSELEILN...SS...FE..NLLL...EKEQE...LVHIKEETDTAIDMLHLQSNELNE.................
D7YRB4_ECOLX/217-346               .......qkg---KSIEQTEKLRAAQEQKTSLKE.QLENVQAKLAQSQDSLATAKAHGESAERECQR....LSGEVEKLDAKLSSAEAEARALV.......QDK..GMMAGQLQEKDQQAKSLEQRL...ND...AL..TKIS...GLEQE...LAKA--------------------gkggkkkeen.......
G1PVZ1_MYOLU/2298-2439             eklkihletd--------EKKQQESKHHADLLKD.RVENLERELEMSRKNHERAILEAENSKAEVDT....LTAKIEEMAPNLRDLELNLVNIR.......SEK..ENLTKELEKEQGRVSELETLN...SS...FE..NLLQ...VREQE...KLQLKEESKLAEERLQAQLKELKE.................
H2Z640_CIOSA/214-338               .......dle---------AKLDRAGDDLASSER.EVRSLRRQLDATQTDLAEASRAKETALRENRR....MQDDLSTLTRENQDINMELDDVM.......RDR..DDLKNKVQDHVGRISSLESSV...SS...KD..RELH...DVLDQ...YRKVT-------------------serdsaesry.......
G1PVZ1_MYOLU/2125-2264             ..........DEKKQLHVLEKLKESERKNDSLQD.KLENLERELQMAEENQEMVILDAENSKAEVET....LKTQIELTTERLKALESNLVAIQ.......SEK..ENLTKQLQEKQGQVSELDTLL...SS...LK..NLLE...EKEQE...NMQTKEESKAAVEMLQTELKELNE.................
Q9GKN4_CANFA/185-324               ..........DEKEQLRVLGKLKETEHQARLLKD.RVESLERELEISGKNQECVVLEAENSKAEVGT....LKVKIEEMAQNLRDLELDLVHIR.......SEK..ENMIKELQKEQERVSELELLN...SS...FE..NLLQ...EKEQE...KVQMSEESKTAVGMLQTQLKELNE.................
H2N3Q4_PONAB/1892-2034             ..........WKERFLDVENELSRIRSEKANIEH.QALSLEADLEVVQTEKLCLEKDSENKQKVIVC....LEEELSVVTSERNQLRGQLDTMS.......KKT..MELDQLSEKMKEKTQELESHQ...SE...CL..HCIQ...VAEAEvkeKTELLQTLSSDVSELLKDKTHLQE.................
Q9GKN1_RABIT/3-142                 ..........DEKKQLHVLEQLKESGHHADLLKN.QVKNLERELELSVKNQQHVLLEAENSKAEAEA....LKSKIGEMASNLRDLELDLFNMR.......SEK..ESMTKELQKEQERVSELEVLN...SS...LE..NTLQ...EKEQE...KIQIKEKSEIAVEMLQAQLKELNE.................
E7FB11_DANRE/1494-1636             ..........WNEKFFQIESELKRVRSEKANLEK.HILSMEADIEEMQEQKQKQEAELETARRTNCS....LEQQLNITMAEGGRLKEELILCT.......DER..ESETHSLMKLKEKADLLEKRE...TD...TK..ELIK...ELEDDirvGKKQNEVASDQISVLLKEKEQLI-q................
G3X012_SARHA/2118-2256             ..........DEKKKHYVLEKLKESERNADSFKD.KVEALERELQMSEENQEAVILDAESTKSELET....LKTQMEELTKGLKCSELELFALR.......AEK..ENILKELQEKQDQVSQLEQLA...YN...LK..FVLSlslEKERM...SIELQENSDHELEELAKNLK----.................
H9Z4G9_MACMU/2130-2269             ..........DERKQLHVAEKLKERERENDSLKD.KVENLERELQMSEENQELVILDAENSKAEVET....LKTQIEEMARSLKVFELDLVTLR.......SEK..ENLTKQIQDKQGQVSELDKLL...AS...VK..SLLE...EKEQA...EIQIKEESKTAVEMLQNQLKELNE.................
G3TYB2_LOXAF/1740-1882             ..........WKEKFLHVENKLERIRSEKVSMEH.HILSVEANLETFQTEKLNLEKDNENKQKVINC....LEEELSVVTTERNQLHGELSTVS.......REN..KELSQMSDRMQKELQELENHH...DE...CL..HHIQ...IVEAEvkeKTVLLQTLSSEKVDLQEQLQSLE-k................
A4IV62_YERPE/217-346               .......qkg---KSIEQTEKLRAAQEQKTSLKE.QLENVQAKLAQSQDSLATAKAHGESAERECQR....LSGEVEKLDAKLSSAEAEARALV.......QDK..GMMAGQLQEKDQQAKSLEQRL...ND...AL..TKIS...GLEQE...LAKA--------------------gkggkkkeen.......
Q9EQN8_MOUSE/185-324               ..........DKKKQCHILEQLKESKHHADLFKD.RVENLEQELMLSEKNKEHLIFQAENSKAEIQT....LKTEIQTMDQNLQDLELELTNTR.......SEK..ENLMKELKNEQEQISKLETIN...SS...IE..RLLK...DKEQE...KVQVKEEARITVEMLQTQLKELNE.................
G5BUR9_HETGA/1804-1936             ..........WKERFLDVENELNRMKAENARIEH.RALTMEADLEVAQTEKLCLEKDNGNSQKVIIH....LEEELSVATSERNRLHGELDAVT.......KEN..KTLAQMSEVMKEKVQALEAEV...RD...RA..AALQ...TLSLQ...VSELSENKRNLQEQL---------rr...............
H9TIX8_SALET/217-346               .......qkg---KSIEQTEKLRAAQEQKTSLKE.QLENVQAKLAQSQDSLATAKAHGESAERECQR....LSGEVEKLDAKLSSAEAEARALV.......QDK..GMMAGQLQEKDQQAKSLEQRL...ND...AL..TKIS...GLEQE...LAKA--------------------gkggkkkeen.......
H0VQV9_CAVPO/2269-2408             ..........DRKEQLQVLEQLKESQCREDLLKG.RVEGLERELELSGRDLEQAVREAENSRAEVQT....LKAEVQELSQHLRDLEADLVNIK.......SEK..EKLTKGLREEQAQVSELEILN...SS...LE..KRLQ...EKEDQ...KVQMREESETAMHMLQAQIKLLTE.................
F1N1F8_BOVIN/2094-2233             ..........DEKKQLHVSEKLKESERRNDSLQD.KVETLERELQMAEENQELVILDAENCKAEVET....LKTQIELMTERLKDLELDLVTIR.......SEK..ENLLKQLQEKQGQASELDTLL...SS...LK..NLLE...EKERE...KIQTKEEAKSAVEMLQTQLRELTE.................
G3S416_GORGO/1868-2010             ..........WKERFLDVENELSRIRSEKANIEH.QALYLEADLEVVQTEKLCLEKDNENKQKVIVC....LEEELSVVTSERNQLRGELDTMS.......KKT..MELDQLSEKMKEKTQELESHQ...SE...CL..HCIQ...VAEAEvkeKTELLQTLSSDVSELLKDKTHLQE.................
D2HFX5_AILME/1892-2032             ..........WRERLLDVENELKRIQSEKGSIEH.HALSLEADLETVQTEKLYLEKDNENQQNVIIR....LEEELSVVTSERNRLHGELDTLS.......KEN..KELDLMSEKMKQKIRELESHQ...GE...CH..IDVA...GAEVR..eQTQLIETLSSDVTKLLEENTHLQE.................
E9Q426_MOUSE/1884-2026             .........y-KEKFLDMERELTRIKSEKANIEH.HILSVETNLEVVQAEKLCLERDTESKQKVIID....LKEELFTVISERNRLREELDNVS.......KES..KALDQMSKKMKEKIEELESHQ...RE...SL..RHIG...AVESEvkdKADLIQTLSFNVGELTKDKAHLQE.................
G9UE79_SALMO/217-346               .......qkg---KSIEQTEKLRAAQEQSTSLKE.QLENAQAKLAQSQDSLATAKAHGESAERECQR....LSGEVEKLETKLSSAEAEARSLV.......QDK..GMIAGQLQEKDQQAKSLEQRL...TD...AL..TKIS...GLEQE...RIKAG-------------------ggekkkeen........
G3S416_GORGO/2288-2427             ..........DEKKQLCVLQQLKESEHHADLLKG.RVENLERELEIARTNQEHAALEAENSKGEVET....LKAKIEGMTQSLRDLELDLVTIR.......SEK..ENLTNELEKEQKRISELEIIN...SS...FE..NILQ...EKEQE...KVQMKEKSSTAMEMLQTQLKELNE.................
G3X012_SARHA/2360-2442             ..........------------------------.--------------------------------....---ELEELTKTLRCVETEVVSLR.......SEKdkENILKELQEKQDQIAELKMLN...VS...FE..SLLE...KKEEE...KRKLKEESNHTVELLQKQLNDLNE.................
H2Q149_PANTR/2313-2452             ..........DEKKQLCVLQQLKESEHHADLLKG.RVENLERELEIARTNQEHAAHEAENSKGEVEA....LKAKIEGMTQSLRDLELDLVTIR.......SEK..ENLTNELQKEQERISELEIIN...AS...FE..NILQ...EKEQE...KVEMKEKSSTAMEMLQTQLKELSE.................
F1S2Y5_PIG/2277-2416               ..........DEKKQLHILEKLKESEHHADLLKD.RVKNLERELEVSGKNQEHAILEAEKSKAEVET....LEAKIEEMAQNLRDSELDLVNIR.......SEK..QDLMKELQKEQGRVSELEKLN...SS...FE..KLLQ...DKEQE...KEQMKEDSKAAVEMFQMQLQELKE.................
H9Z4G9_MACMU/2312-2451             ..........DEKKQLCVLEQLKESEHHADLLKS.RVENLERELEIAGKNQEHAALEAENSKGEVET....LKAKIEGMTQSLRDLELDLATVR.......SEK..ENLTNKLQKEQERISELEIIN...SS...FE..NILR...EKEQE...KVQMKEKSNTAMEMLQTQLKELHE.................
A0PBP5_PASPI/217-346               .......qkg---KSIEQTEKLRAAQEQKTSLKE.QLENVQAKLAQSQDSLATAKAHGESAERECQR....LSGEVEKLDAKLSSAEAEARALV.......QDK..GMMAGQLQEKDQQAKSLEQRL...ND...AL..TKIS...GLEQE...LAKA--------------------gkggkkkeen.......
Q9GKN3_BOVIN/3-142                 ..........DEKKQLHVSEKLKESERRNDSLQD.KVETLERELQMAEENQELVILDAENCKAEVET....LKTQIELMTERLKDLELDLVTIR.......SEK..ENLLKQLQEKQGQASELDTLL...SS...LK..NLLE...EKERE...KILTKEEAKSAVEMLQTQLKELNE.................
G3TYB2_LOXAF/2153-2292             ..........DKKKQLHVLEKLQESEQSANLLKG.RVVNLERKLEVAGKNQELVILDAENSKAEKET....LKIKMGELAQNLRDLELDLANIR.......SEK..ESLTRELQTEQGRVSELEMLN...SS...FE..NLLQ...EKEQE...KVQMKEESKIAVELLQTQLKELNE.................
G3S416_GORGO/2106-2245             ..........DEKRQLHVAEKLKERERENDSLKD.KVENLERELQMSEENQELVILDAENSKAEVET....LKTQIEEMARSLKVFELDLVTLR.......SEK..ENLTKQIQEKQGQLSELDKFL...SS...FK..SLLE...EKEQA...EIQIKEESKTAVEMLQNQLKELNE.................
G5BUR9_HETGA/2028-2167             ..........DEKKQLHVLGKLKGSERDNDVLRD.KVEGLQRELQMSEENQELVVLDAENAKAEMET....LRAQLDELAESLRGSQVDLAVLR.......SEK..GDLTKQLQEKQGQVSELDGLL...SS...LK..SLLE...EKEQA...RAQMQEESKTAVEMIQAQLRELTE.................
E7FFC1_DANRE/2025-2168             ..........DERKKNHMSQLLKAAQRKADVLQD.NIEKLEREKELSEQNLEDAILQAETAKAELEE....IQAETQDLTKKIEEMTSELKDLK.......EEK..YKLEQELDQKNKLIEELQLSI...QE...AS..VKLK...SAEEAtlnQEQMIKDFQFKVGAMEEEL-----rlfqte...........
G7MEK3_MACMU/1892-2034             ..........WKERFLDVENELSSIRSEKANIEH.QALSLEADLEIVQTEKLCLEKDNENNQKVIVC....LEEELSVVTSERNQLRGELDTMS.......KKI..MELDQLSEKMKEKTQELESHR...SE...YL..HCIQ...VAEAKvkeKTELLQTLSSDVSELLKDKTHLQE.................
F6WML7_ORNAN/2151-2297             ..........DEKEKQHITGKLKESERKADSLQD.KIEALERQLQMAEENQEAMILDAETAKMEAET....LKTKIEELTGRLQGLELEFGALRlekenviEEK..ETIAKDLQEKQDRMSELESCN...SS...FE..KLLE...NKEQE...IVRMEEESKNAIELLQVQLKDLK-d................
CENPF_HUMAN/2227-2366              ..........DEKKQLHIAEKLKERERENDSLKD.KVENLERELQMSEENQELVILDAENSKAEVET....LKTQIEEMARSLKVFELDLVTLR.......SEK..ENLTKQIQEKQGQLSELDKLL...SS...FK..SLLE...EKEQA...EIQIKEESKTAVEMLQNQLKELNE.................
F6VU99_ORNAN/1615-1761             ..........DEKEKQHITGKLKESERKADSLQD.KIEALERQLQMAEENQEAMILDAETAKMEAET....LKTKIEELTGRLQGLELEFGALRlekenviEEK..ETIAKDLQEKQDRMSELESCN...SS...FE..KLLE...NKEQE...IVRMEEESKNAIELLQVQLKDLK-d................
E9PT83_RAT/2293-2431               ..........DKKKQCHILEQLKESKHHADLFKD.RVENLEQELMLSEKNKEHLIFQAENSKAEIQT....LKTEIQTMDQNLQDLELELTNTR.......SEK..ENLMKELKNEQEQISKLETIN...SS...IE..RLLK...DKEQE...KVQGKEEA-IPVEMLQTQLKELNE.................
G1MBM9_AILME/1893-2033             ..........WRERLLDVENELKRIQSEKGSIEH.HALSLEADLETVQTEKLYLEKDNENQQNVIIR....LEEELSVVTSERNRLHGELDTLS.......KEN..KELDLMSEKMKQKIRELESHQ...GE...CH..IDVA...GAEVR..eQTQLIETLSSDVTKLLEENTHLQE.................
G1U7C9_RABIT/1857-1999             ..........WKERFLDVENELNMMKSEKASIEL.QALSVKKDLEIVQTEKLDLEKNNENKQKVIEC....LEEELSVVTSERNQFHEELDTVL.......KEK..KALDRMSEEMKEKMQELESRH...SE...CL..HHIQ...VVEAEvkeKTDCVQTLSSEVNKLLKDKTHLQE.................
E9Q3P4_MOUSE/2131-2270             ..........DEKKHLSAVAKLKESQRESDSLKD.TVETLERELERSEENQELAILDSENLKAEVET....LKAQKDEMTKSLRIFELDLVTVR.......TER..ENLAKQLQEKQSRVSELDERC...SS...LR..RLLE...EKEQA...RVQMEEDSKSAMLMLQMQLKELRE.................
F6WML7_ORNAN/1913-2051             ..........WKEKCLEIEKELKRVKSEKANVEN.HALTMESDFEELQTQRRNLENDNENKRETITS....LQEQLSVITSERNQLTEELNALS.......EEK..AIVGQDCEKLKEKIKDFETSE...EE...SI..RHIQ...RVESEvkeKTVLVQAL----------------ssdinhlsrdkd.....
H2TCJ9_TAKRU/2146-2283             ..........DERKKKKMRELLKAAQRKSDSLQD.HIDALVREHADIESSLEEAVLQAETSKEELEE....VEEEKMVLSNKLSEFSIALQHLR.......SEK..KHV--ELELKNREIEDLKAAK...ED...ME..RGLE...RAEAG...KRQKEERQKHRVEQLEKEVKEDAE.................
A4IVQ2_SALNS/217-346               .......qkg---KSIEQTEKLRAAQEQKTSLKE.QLENVQAKLAQSQDSLATAKAHGESAERECQR....LSGEVEKLDAKLSSAEAEARALV.......QDK..GMMAGQLQEKDQQAKSLEQRL...ND...AL..TKIS...GLEQE...LAKA--------------------gkggkkkeen.......
F2Z852_SALTM/217-346               .......qkg---KSIEQTEKLRAAQEQKTSLKE.QLENVQAKLAQSQDSLATAKAHGESAERECQR....LSGEVEKLDAKLSSAEAEARALV.......QDK..GMMAGQLQEKDQQAKSLEQRL...ND...AL..TKIS...GLEQE...LAKA--------------------gkggkkkeen.......
G1U7C9_RABIT/2277-2416             ..........DEKKQLHVLEQLKESGHHADLLKN.QVKNLERELELSVKNQQHVLLEAENSKAEAEA....LKSKIGEMASNLRDLELDLFNMR.......SEK..ESMTKELQKEQERVSELEVLN...SS...LE..NTLQ...EKEQE...KIQIKEKSEIAVEMLQAQLKELNE.................
G1RW78_NOMLE/2313-2452             ..........DEKKQLCVLEQLKESEHHADLLKG.RVENLERELEIARTNQEHAALEAENSKGEVET....LKAKIEGMTQSLRDLELDLVTIR.......SEK..ENLTNELQRELERISELEIIN...SS...FE..NILQ...EKEQE...KVQMKEKSSTAMEMLQTQLKALNE.................
Q98940_CHICK/857-996               ..........DERKTRHIAEKLKENERKSDALLD.KVERLERELEMSEENLEDAVVQLATAKAEAET....FITEKEEMAEKLKCLQSQLDDLT.......SQK..ECLAKDSKEKQERILELESSN...LT...TA..KLLE...EKEEE...KMQIKDEFENAVLLLKSELKGMSE.................
Q9EQN8_MOUSE/3-142                 ..........DEKKQLSAVAKLKESQRESDSLKD.KVENLERELEMSEENQELAILDSENLKAEVET....LKAQMDEMAKSLRVFELDLVNVR.......SER..ENLAKQLQEKQSRVSELDELC...SS...LR..SLSE...EKEQA...RVQMERDSKSAMLMLQTQLKELWE.................
G7NUK3_MACFA/2312-2451             ..........DEKKQLCVLEQLKESEHHADLLKS.RVENLERELEIAGKNQEHAALEAENSKGEVET....LKAKIEGMTQSLRDLELDLATVR.......SEK..ENLTNKLQKEQERISELEIIN...SS...FE..NILR...EKEQE...KVQMKEKSNTAMEMLQTQLKELHE.................
H0VQV9_CAVPO/2087-2226             ..........DEKRQLDVLQKLRGSERENDVLRD.KVEGLQRELQMSEENQELVILDAENAKAEVEI....LRAQVEEVGESLRDSQADLAVLR.......SEK..GDLAKQLQEKQGHVEELEALV...SS...LR..SLVE...EKERA...RVQMQEDSKTMVETIQAQLRELTE.................
E7FFC1_DANRE/1787-1929             ..........WNEKFFQIESELKRVRSEKANLEK.HILSMEADIEEMQEQKQKQEAELETARRTNCS....LEQQLNITMAEGGRLKEELILCT.......DER..ESETHSLMKLKEKADLLEKRE...TD...TK..ELIK...ELEDDirvGKKQNEVASDQISVLLKEKEQLI-q................
F7A8M3_XENTR/1732-1864             ..........DEKKKNHLIGKLKETERNSDHLKD.KIENLERELLMSEENLESTILQSESSKEEVEK....LKSMKEA-------LEANVNTFR.......RRI..VDLERELEKSKERIEELETRV...LT...LS..NALE...KSEME...KSCLNEESGQELLLLRAQLNELQE.................
#=GC seq_cons                      ...........ccKpLcltpcL+cscccpssLcc.+lEsLEp-Lphupcspppshh-uEsu+tElps....Lcscl-phsppLpsLch-Lsslp.......pEK..csLsppLpccpp+lpELEphp...ss...hp..phlp...ptEpE...chphtcp.psshp.LppphpcLpE.................
//
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