GenomeNet

Database: Pfam
Entry: CENP-H
LinkDB: CENP-H
Original site: CENP-H 
#=GF ID   CENP-H
#=GF AC   PF05837.7
#=GF DE   Centromere protein H (CENP-H)
#=GF AU   Moxon SJ
#=GF SE   Pfam-B_8705 (release 8.0)
#=GF GA   23.00 23.00;
#=GF TC   25.30 25.00;
#=GF NC   22.90 22.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   CENPH
#=GF RN   [1]
#=GF RM   10488063
#=GF RT   Characterization of a novel kinetochore protein, CENP-H. 
#=GF RA   Sugata N, Munekata E, Todokoro K; 
#=GF RL   J Biol Chem 1999;274:27343-27346.
#=GF RN   [2]
#=GF RM   11500386
#=GF RT   CENP-H, a constitutive centromere component, is required for
#=GF RT   centromere targeting of CENP-C in vertebrate cells. 
#=GF RA   Fukagawa T, Mikami Y, Nishihashi A, Regnier V, Haraguchi T,
#=GF RA   Hiraoka Y, Sugata N, Todokoro K, Brown W, Ikemura T; 
#=GF RL   EMBO J 2001;20:4603-4617.
#=GF DR   INTERPRO; IPR008426;
#=GF CC   This family consists of several eukaryotic centromere protein H
#=GF CC   (CENP-H) sequences. Macromolecular centromere-kinetochore
#=GF CC   complex plays a critical role in sister chromatid separation,
#=GF CC   but its complete protein composition as well as its precise
#=GF CC   dynamic function during mitosis has not yet been clearly
#=GF CC   determined. CENP-H contains a coiled-coil structure and a
#=GF CC   nuclear localisation signal. CENP-H is specifically and
#=GF CC   constitutively localised in kinetochores throughout the cell
#=GF CC   cycle. CENP-H may play a role in kinetochore organisation and
#=GF CC   function throughout the cell cycle [1]. This the C-terminus of
#=GF CC   the region, which is conserved from fungi to humans.
#=GF SQ   119
#=GS G3QGP4_GORGO/136-241  AC G3QGP4.1
#=GS Q0P4K1_XENTR/138-242  AC Q0P4K1.1
#=GS E3QDF7_COLGM/121-230  AC E3QDF7.1
#=GS F8MZG8_NEUT8/96-205   AC F8MZG8.1
#=GS C1BYA2_ESOLU/126-230  AC C1BYA2.1
#=GS B3KVZ3_HUMAN/117-222  AC B3KVZ3.1
#=GS F0ZEI0_DICPU/172-273  AC F0ZEI0.1
#=GS Q5B994_EMENI/128-236  AC Q5B994.1
#=GS F0U813_AJEC8/137-245  AC F0U813.1
#=GS B8M4Y6_TALSN/133-241  AC B8M4Y6.1
#=GS F7IJ38_CALJA/117-222  AC F7IJ38.1
#=GS F6PLT4_HORSE/135-240  AC F6PLT4.1
#=GS FTA3_SCHPO/111-209    AC O94261.1
#=GS F7BNS0_XENTR/136-239  AC F7BNS0.1
#=GS D4DK94_TRIVH/131-239  AC D4DK94.1
#=GS G4MS99_MAGO7/125-236  AC G4MS99.1
#=GS A6RR02_BOTFB/100-208  AC A6RR02.1
#=GS C5JUC6_AJEDS/137-245  AC C5JUC6.1
#=GS A7RSC2_NEMVE/135-240  AC A7RSC2.1
#=GS F7HY66_CALJA/136-241  AC F7HY66.1
#=GS D4B356_ARTBC/131-239  AC D4B356.1
#=GS C5FS81_ARTOC/123-231  AC C5FS81.1
#=GS B6Q331_PENMQ/133-241  AC B6Q331.1
#=GS G2WZ89_VERDV/119-235  AC G2WZ89.1
#=GS C1GTZ3_PARBA/76-184   AC C1GTZ3.1
#=GS B2AM45_PODAN/106-215  AC B2AM45.1
#=GS C3KH67_ANOFI/127-231  AC C3KH67.1
#=GS G2Q1Y8_THIHA/109-217  AC G2Q1Y8.1
#=GS E9CYZ8_COCPS/133-240  AC E9CYZ8.1
#=GS A7E7B6_SCLS1/121-230  AC A7E7B6.1
#=GS F9GGB7_FUSOF/38-122   AC F9GGB7.1
#=GS G1X4K7_ARTOA/147-251  AC G1X4K7.1
#=GS C0NUZ1_AJECG/137-245  AC C0NUZ1.1
#=GS G3J8R7_CORMM/141-242  AC G3J8R7.1
#=GS Q6CEC4_YARLI/129-231  AC Q6CEC4.1
#=GS G5BKN6_HETGA/97-202   AC G5BKN6.1
#=GS G3Y3L7_ASPNA/131-239  AC G3Y3L7.1
#=GS B0XXC4_ASPFC/129-237  AC B0XXC4.1
#=GS F0XUY0_GROCL/183-294  AC F0XUY0.1
#=GS Q7S057_NEUCR/96-205   AC Q7S057.1
#=GS B8N1N6_ASPFN/129-237  AC B8N1N6.1
#=GS B7FSK2_PHATC/135-244  AC B7FSK2.1
#=GS Q4RUR4_TETNG/31-135   AC Q4RUR4.1
#=GS G0RDU4_HYPJQ/122-231  AC G0RDU4.1
#=GS F7W180_SORMK/114-223  AC F7W180.1
#=GS H2LZ13_ORYLA/11-41    AC H2LZ13.1
#=GS E9EWB2_METAR/125-233  AC E9EWB2.1
#=GS G7XPL2_ASPKW/129-237  AC G7XPL2.1
#=GS H0VRH0_CAVPO/1-97     AC H0VRH0.1
#=GS E3RR68_PYRTT/165-268  AC E3RR68.1
#=GS F6QC79_MONDO/96-201   AC F6QC79.1
#=GS CENPH_HUMAN/136-241   AC Q9H3R5.1
#=GS H3IHD5_STRPU/160-262  AC H3IHD5.1
#=GS B2WEL0_PYRTR/131-236  AC B2WEL0.1
#=GS CENPH_MOUSE/130-235   AC Q9QYM8.1
#=GS CENPH_CHICK/122-226   AC Q90ZF9.1
#=GS B6K0U9_SCHJY/99-224   AC B6K0U9.1
#=GS C0S3I9_PARBP/140-248  AC C0S3I9.1
#=GS G7P7N4_MACFA/136-241  AC G7P7N4.1
#=GS A8WHV8_DANRE/126-229  AC A8WHV8.1
#=GS A1D6R3_NEOFI/129-237  AC A1D6R3.1
#=GS F9G357_FUSOF/121-229  AC F9G357.1
#=GS C3YVM5_BRAFL/129-233  AC C3YVM5.1
#=GS Q4P7V5_USTMA/156-297  AC Q4P7V5.1
#=GS Q4WY32_ASPFU/129-237  AC Q4WY32.1
#=GS F2TJI4_AJEDA/137-245  AC F2TJI4.1
#=GS G4U9C1_NEUT9/131-240  AC G4U9C1.1
#=GS CENPH_BOVIN/133-238   AC Q3T0L1.1
#=GS F6RXE0_XENTR/138-243  AC F6RXE0.1
#=GS F2PHW1_TRIEC/131-239  AC F2PHW1.1
#=GS E4UNM1_ARTGP/131-239  AC E4UNM1.1
#=GS E9E019_METAQ/124-232  AC E9E019.1
#=GS D2H2T8_AILME/1-56     AC D2H2T8.1
#=GS F2UDY6_SALS5/143-247  AC F2UDY6.1
#=GS G9NA91_HYPVG/112-220  AC G9NA91.1
#=GS C5G7F8_AJEDR/137-245  AC C5G7F8.1
#=GS F2S7D6_TRIT1/131-239  AC F2S7D6.1
#=GS F7GDG6_ORNAN/1-53     AC F7GDG6.1
#=GS E6ZMG3_SPORE/160-297  AC E6ZMG3.1
#=GS C1C3S7_LITCT/86-189   AC C1C3S7.1
#=GS G1QVE6_NOMLE/136-241  AC G1QVE6.1
#=GS D8M956_BLAHO/140-245  AC D8M956.1
#=GS H0Y9E6_HUMAN/76-181   AC H0Y9E6.1
#=GS H0ZVC1_TAEGU/72-176   AC H0ZVC1.1
#=GS E9C9D8_CAPO3/157-269  AC E9C9D8.1
#=GS H1V387_COLHI/121-230  AC H1V387.1
#=GS B6H4J5_PENCW/129-237  AC B6H4J5.1
#=GS F7GYV6_MACMU/136-241  AC F7GYV6.1
#=GS G3W0S9_SARHA/97-202   AC G3W0S9.1
#=GS G9P907_HYPAI/116-225  AC G9P907.1
#=GS G1L8V0_AILME/135-241  AC G1L8V0.1
#=GS H0W563_CAVPO/104-199  AC H0W563.1
#=GS C5P9N1_COCP7/133-240  AC C5P9N1.1
#=GS C4JZ24_UNCRE/132-239  AC C4JZ24.1
#=GS Q0CNP0_ASPTN/129-237  AC Q0CNP0.1
#=GS E2R8X4_CANFA/139-244  AC E2R8X4.1
#=GS C6HRL4_AJECH/137-245  AC C6HRL4.1
#=GS G2YBK7_BOTF4/126-235  AC G2YBK7.1
#=GS H0WK59_OTOGA/135-240  AC H0WK59.1
#=GS B9EMR0_SALSA/129-233  AC B9EMR0.1
#=GS G2R207_THITE/121-227  AC G2R207.1
#=GS H2QR06_PANTR/136-241  AC H2QR06.1
#=GS C1G1C0_PARBD/76-184   AC C1G1C0.1
#=GS A2QDK2_ASPNC/74-182   AC A2QDK2.1
#=GS F2SW09_TRIRC/131-239  AC F2SW09.1
#=GS Q0UIN8_PHANO/130-239  AC Q0UIN8.2
#=GS H2PFR2_PONAB/136-241  AC H2PFR2.1
#=GS G5B8V0_HETGA/131-236  AC G5B8V0.1
#=GS F1M389_RAT/131-236    AC F1M389.1
#=GS G1PLH1_MYOLU/94-199   AC G1PLH1.1
#=GS F7HY65_CALJA/136-242  AC F7HY65.1
#=GS I1RA59_GIBZE/121-230  AC I1RA59.1
#=GS C9SMQ0_VERA1/27-143   AC C9SMQ0.1
#=GS A6QRL1_AJECN/109-208  AC A6QRL1.1
#=GS G1KSK7_ANOCA/91-196   AC G1KSK7.1
#=GS A1CKR0_ASPCL/129-237  AC A1CKR0.1
#=GS C3YVL8_BRAFL/24-107   AC C3YVL8.1
#=GS E5A8D5_LEPMJ/50-159   AC E5A8D5.1
#=GS Q2UKQ1_ASPOR/157-265  AC Q2UKQ1.1
G3QGP4_GORGO/136-241             ...........................................................................LNKLIMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................SMENSERIKIIRQNLQMEIKITTVIQHVFQ.NLILGSKVNWAEDPALKEIVLQLE........
Q0P4K1_XENTR/138-242             ...........................................................................LSSSVMNLQQETRDLEEKM.YDIRKKRLVLKEQGSAKMLEIQTMKSNWKANRE.....................-EMKNEKIKRLHKVLKEEIDSVTVLQNVFQ.NIILASHVDWAKYPQLKDIVLRLE........
E3QDF7_COLGM/121-230             ......................................................................tsvtl-----SETSSDIRAAINEL.TEVEAESLRVGRRNVELTAEILRLTEEAEARRMge.................tgDFGVQGDMYRLQAEVKASRQRWKVMKGTAS.AIVVGSGIDWTRDEALTDIVLD--pe......
F8MZG8_NEUT8/96-205              ...........................................................................ISAEAAEQASASYQVRDHI.LDLELERLRVGQHNATLASELLRLSKTTGTHNVqv.................dgSTKLGRKLGKTKGELRVSRQKWKTIKGATS.ALVAGTGVDWARDERLRDLVLD--pp......
C1BYA2_ESOLU/126-230             ...........................................................................LCLKIKTLQQESFELQDQI.TALQKQRLDLKRLTHEKMKEMEELKTKGEHPVA.....................-EEYRNVLQKAQSYLEKYQKMVAIEQNVLR.GIIIASKVNWREDPKLREIAMTL-e.......
B3KVZ3_HUMAN/117-222             ...........................................................................LNKLIMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................SMENSERIKIIRQNLQMEIKITTVIQHVFQ.NLILGSKVNWAEDPALKEIVLQLE........
F0ZEI0_DICPU/172-273             ............................................................lklskirdegveicl----------------KLI.SQIELNNDEILKIRKKRIEEMK-LNRETYNNLKm...................kLEESKSKTEREQKNYSVLKDKTSLLGFIIQ.NLVYESGIDWVKDDEIT-------yff.....
Q5B994_EMENI/128-236             ...........................................................................LSLALENFTEAQASTLKKL.SSLEVENLQLHRQNQELVRELLELTEDDESWREq..................ldDPELKQQLEQLEAEHKQSKAKWETMKSVAS.AIIVGSGVDWAEDEDLTALVLDD-l.......
F0U813_AJEC8/137-245             ...........................................................................LSLIYVNLSRAHGSCTQSL.SNTKVDGMHGTAKTQELVQTLLGLTSAEKSRREa..................itDPALISQLEAQEKETKAERASWVTMKRVVS.ALIVASGIDWAADEALHDLVVDDE........
B8M4Y6_TALSN/133-241             ...........................................................................LSLVYENLANARTATVEAL.SNAEVENLRLMEQNKGLASELLELTAQETSWRDr..................vdDEALIARMEEIEQEYKKTRAQRDTIKSVLS.ALVVGSGVDWARDDRLRDSVLEE-l.......
F7IJ38_CALJA/117-222             ...........................................................................LNKLVMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................GMENSERIKIIRQNLQMEIKITTVIQHVFQ.NLILGSKVNWAEDPALKETVLQLE........
F6PLT4_HORSE/135-240             ...........................................................................LNKLIMKSQQESWDLEEKL.LDVRKKRLQLKQASESKLLEIQTEKNKQKDDLD.....................SMENSDKIKTIQQNLQMEIQITTVIQHVFQ.NLILGSKANWAEDSAFKETVLQLE........
FTA3_SCHPO/111-209               ...........................................................................LSEENLKIESSITFTSEEI.EKEKENIKSVLLPSVQSISSSLELYASKESDYR.....................-----SSIEGVLADLKLARARWEIVRNVTQ.ILLLESGISFLENKKLAYIM----dl......
F7BNS0_XENTR/136-239             ..........................................................................i-CKMIQAVQSSNRILEEKL.ASVRKSRMEVRLLQQELFKKVKITEERKNKLQE.....................-IEMKTQVV-GKENMDTVANKVIIIQEIFQ.RCILSTHTDWSEDPHLTRLLLK--mk......
D4DK94_TRIVH/131-239             ...........................................................................LSLAYENMLSTHTTCLRKL.SSAEVSNIQNIKQNQELVQSLLKLTSNDKSADEe..................ipDLELKEELNRLKSENKQKKAQWTRIKRIVS.ASIAASGVDWASDEKLESLVLDDD........
G4MS99_MAGO7/125-236             .........................................................................as--IAVANQTTALHETLDKL.TSVEADSLALSRKNVELAAEMLDLVQEHEARRKgvt...............adeDPDTAAEIRRLEGQVQASRRRWRIMKGTAG.AVVVGSGVDWVGDPVLRDVVLDS-e.......
A6RR02_BOTFB/100-208             ...................................................................lkavhags---------NASIMEQEEL.MRESNENIVTGRKNIELATEMLALAEEANSQGKen.................iqDPDVRAQLDELEGAMKNSRQRWRIMKNTAS.AVIVGSGIDWARDPKLLALVLDDD........
C5JUC6_AJEDS/137-245             ...........................................................................LSLIYTNLSRAHASCTQSL.STAKVDSIHSTAKNQKLVQTLLGLTSAQTSWREg..................itDQKLRSQLETLEKETKAEKANWVTIKRIVS.AAIVASGVDWAADEQLHDLVVDDD........
A7RSC2_NEMVE/135-240             ...........................................................................LCSEILRQHQAMLETQQEL.DQVKQQSLAMKKRNRELMAKLKDLQRRQSQGEH.....................NSSEVEAIAKAKDGLNDSKRKLRVVGNIFQ.GLIVGSGINWAADDSLRQLMIEL-g.......
F7HY66_CALJA/136-241             ...........................................................................LNKLVMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................GMENSERIKIIRQNLQMEIKITTVIQHVFQ.NLILGSKVNWAEDPALKETVLQLE........
D4B356_ARTBC/131-239             ...........................................................................LSLAYENMLTTHTTCLRKL.SSAEVSNIQNIKQNQELVQSLLKLTSSEKSADEe..................ipDLELKEELNSLKSENKQKKAQWTRIKRIVS.ASIAASGVDWASDEKLERLVLDDD........
C5FS81_ARTOC/123-231             ...........................................................................LSLAYENIMTSHTACIREL.SSAEVANIQSIQKNQELVQTLLELTRNEKSLDDn..................isDPQLKEELDSLRTENKQKKAHWTRIKRIVS.ASIAASGVDWASDEKLENLVLDDD........
B6Q331_PENMQ/133-241             ...........................................................................LSLVYENLVNARTTTVEAL.SNAEVENLRLMEQNKGLASELLELTAQETLWRDr..................idDEAVIAQMEDIEQEYKKTRARRDTIKSVIS.ALVVGSGVDWARDDRLRSLVLDE-l.......
G2WZ89_VERDV/119-235             .........................................................................as--ATLARNATSLRDTLDAL.AATRAKALSAGRRNAELAQEVLRLAEEAARRRGggsgp..........kgsggeDDETRRETQLLRAGLKASRQKWKVMKGTAS.AIVVGSGVDWVGDEGLRWMVLD--pe......
C1GTZ3_PARBA/76-184              ...........................................................................LSLIYENLSRAHASCIQTL.SDAKVENIQHNEKNQQMVQTLLGLTSAEKTWREe..................itDPKLRAQLETVEKECKAEQANWVTIKRIVS.AAIVASGIDWAEDEKLCDLVVDD-v.......
B2AM45_PODAN/106-215             ...................................................................aakrtaeh--------CSALHSAMERL.TKVEVEYLETKQRNVELASETLDLAADNVGQEPnn.................viNTQLKMELDTLETQLRATRGKWRVMKGTAS.AIVAGSGLDWVRDERLRELVLD--id......
C3KH67_ANOFI/127-231             ...........................................................................LCSQIKQLQQESRDLQDGI.TEVQKKRLEMKRLTHEKMKEMDELMSKTGHPDT.....................-EKYRAVLEKGQANLEKYKKMTVMTQNVLR.GILLACKVNWLDDPKLRDIAMTL-g.......
G2Q1Y8_THIHA/109-217             ........................................................................aat---KAANIYSELQTARARL.AELEVGSLKASHWNRELAADVLQLASENHKQDFes.................iqNGRFGSGIADLESQVKSSRHRWRIIKGATS.AIIAGSGIDWVRVKRLRELVLD--p.......
E9CYZ8_COCPS/133-240             ...........................................................................LSLVYENLAGVNNSCVENL.SNAEVSNIRAVKDNRDLVRSLLELTDGNAEEEEi...................kDLKSKEELETLKRENKNRRDEYMTMKRIVS.AVIVASGLDWASDEKLLTLVVEDE........
A7E7B6_SCLS1/121-230             ...........................................................................LSENLAQVSNNLQSSREEL.MKESNENIITGRKNVELATEMMVLAEEASSQGKen.................iqDPEVRAQLDELEAAMKNSRQRWRIMKNTAS.AVVVGSGVDWARDPKLLEIVLDDD........
F9GGB7_FUSOF/38-122              ....................................................................enkkiek------DFQLSINEVRLKL.SDLTGQRSQLKESQSRLARELAKVEAKLSRTTD....................eCQEKVSQLGRIEQDYHASRKKRT-------.------------------------etlhdiwf
G1X4K7_ARTOA/147-251             .......................................................................latt----LIHLTSQLSTLQEAH.NRSSAKLTSLTKSNKSLAEQLKQLSLEHEISEN.....................-ITTNEKLIAAKEETMKAQRQCRTLKGVLQ.GIIAGSGVDWAEDDVLRELVLE--cg......
C0NUZ1_AJECG/137-245             ...........................................................................LSLIYVNLSRAHASCTQSL.SNTKVDSMHGTAKTQELVQTLLGLTSAEKSRREa..................itDPALISQLEAQEKETKAERASWVTMKRVVS.ALIVASGIDWAADEALHDLVVDDE........
G3J8R7_CORMM/141-242             ........................................................................avd----AARSATQAQATRDAL.TDVQVETLRACRRNVQLTSRVFELAAQLEARKA.....................---VDWDGGEEALRVRDEKRKWRAVKGAAS.GIVAGSGVDWASDEALRDMVLD--pe......
Q6CEC4_YARLI/129-231             ..........................................................................k-SRDLLDSLIVVTGLRKQL.DVLICENRASLDTQRSIVRSIEKANDKSADRHQ.....................---NNQAISELEAKLHNTKNKRRVLAEIFT.ALITASGIDWCEDEDLVQLIVG--ag......
G5BKN6_HETGA/97-202              ...........................................................................LNKSVMKLQQESWELEEKL.LDVRKKRFQLKQASESKLLEIQTEKKKQKEELA.....................SMENSDKIKTMKQSLQREIQIATVIQHVFQ.NLILGSKVNWAADPALKETVLELE........
G3Y3L7_ASPNA/131-239             ...........................................................................LSLAHENLNTAHNATLRRL.SSLEVENSQIHQQNQELVRELLALTVDDESWREn..................leDAELKAQLDQLDADRRKSKAKWETMKNIAS.GMVVGSGVNWAEDERLTALVLDE-s.......
B0XXC4_ASPFC/129-237             ...........................................................................LSLAHENLMNAHNATLREL.SNLEVQNLELHQRNQELARQLLESAKDDDSWREa..................ldDDDLKAQLEQLEADRKKSKSRWEVMKSVAS.AIVVGSGVNWAEDDELTALVIDE-s.......
F0XUY0_GROCL/183-294             ..........................................................................a-SQAVAQQAGARRAVLERH.VAVAAESCRVRRQNQALAEQLHRQLAEAVEDDSagg...............dknNDTHDDELTQLQQELKASRQRWKLIKGTAS.AVVVGSGVDWARDPELQNLVLD--pe......
Q7S057_NEUCR/96-205              ...........................................................................ISAEAAEQASASYQVRDHI.LDLELERLRVGQHNATLASELLRLSKTTGTHDVqv.................dgSTKLGRKLGKTKGELRVSRQKWKTIKGATS.ALVAGTGVDWARDERLRDLVLD--pp......
B8N1N6_ASPFN/129-237             ...........................................................................LSLAHENLNTALSSTLKKL.SNAEVENLQLHQKNKALVRELLDLTKNDESWREe..................ldDMSIKELLEQVKADHKRSKAKWETMKSITS.AIVVGSGVNWAEDEELVALVLDD-s.......
B7FSK2_PHATC/135-244             .......................................................................ddll-------LQQAQQVCQRQV.QRALEKSRELEQVQQDVMTATEDSRRMQTESRScwe..............slvrEGEDDVVISNASTKESKDERQLRVLGRVLV.DLVTSSNIDWYEDDKLQEIMQ---rle.....
Q4RUR4_TETNG/31-135              ...........................................................................LCSHIKQLQQESRELQDEI.IDIQKRRLEMKRLTHEKIKEMEELMAKKEPPDS.....................-QKYKAALEKGQSNLEKYKKMAVMTQNVLR.GIILACKINWMDDPKLRDIAMSLE........
G0RDU4_HYPJQ/122-231             ........................................................................tsi---SVAKHADSMAKLRRDL.ASVQVQSIRVCRENVKLTAQVFELAEQAKQRKAvr.................ldDPDVQREMDKLTREVKASRQRWKVMKGVAS.GIVAGSGVDWAADEELRNIVLD--pe......
F7W180_SORMK/114-223             ..........................................................................v-SAKAAQQASASYEVRDRM.LTLELNRIRVGQQNATLASELLRLSKTTGATDVev.................dgATKLQRQLDKTKGELQVSRQRWKTIKGATS.VLVAGSGVDWVRDERLRGLVLD--pp......
H2LZ13_ORYLA/11-41               .....................................................................nvllsh-------------------.---------------------------------.....................-----------------------------Q.GLLLACKINWLDDPKLRHVAMTLE........
E9EWB2_METAR/125-233             ........................................................................ain----VAKHATEVAFIRNDL.TEVQSDTARVIRRNVDLTSTLFELAEEVKQKQAsr.................ldDEETQSEIRQLEVAMRASRQRWRVIKGVAS.GIVAGSGVDWARDAKLREVVLDLD........
G7XPL2_ASPKW/129-237             ...........................................................................LSLAHENLNTAHSATLRRL.ASLEVENSQIHRQNQELVRELLALTEDDESWREn..................leDAELKAQLDQLDADRRKSKAKWETMKNIAS.GMVVGSGVNWAEDERLTALVLDE-s.......
H0VRH0_CAVPO/1-97                ...........................................................................---------QESWELEEKL.LDIRKKRLQLKHASENKLLEIQTEKKKRKEELN.....................SMGNSDKIKTMQQILQTEMEIATVIQHVFQ.NIILGSKVNWAADPALKETVLQLE........
E3RR68_PYRTT/165-268             .......................................................................lets----------KLAGVRRAL.SVAEQGNILAKQKNRELAQTMVALAEEMKKQSAqd.................ieDAQLRQRVEGVEKEVKESRRRVRTVRGMLS.AMVVGSGINWAADEALTELVMDDE........
F6QC79_MONDO/96-201              ...........................................................................LNSSILKAQQETHDLEEKL.LEVKKKRLRLKQAGEEKLLEIQAEDKKKKEKLE.....................LLEDSALLSKLKKNLQREIESTTVIQNVFQ.HIIIATKIDWASDPDLKVLVLQLE........
CENPH_HUMAN/136-241              ...........................................................................LNKLIMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................SMENSERIKIIRQNLQMEIKITTVIQHVFQ.NLILGSKVNWAEDPALKEIVLQLE........
H3IHD5_STRPU/160-262             ...........................................................................LSSDILAHLNACQSLQDDV.DQGKKDIRDIQAGNVELMKKLQSRESADKMNDT.....................---PSNSVQRQQEKLDDLISHITMEKGILQ.GLIIGSGVNWAKDPALKEVVIGL-g.......
B2WEL0_PYRTR/131-236             .....................................................................hglets----------KLAAVTRTL.SVAEQGNIAAKQKNRELAQTMLALAEEMKKQSAqd.................iqDAQLRQRVDAVEKEVKESRRRVSTLKGILS.AMVVGSGINWAADEALTELVMDDE........
CENPH_MOUSE/130-235              ...........................................................................LQKLIMKSQEESSELEKKL.LDVRKKRLQLKQASRSKLLEIQIEKNKQKEDVD.....................KMENSEMIKTMKKKLQTEIKITTVVQHTFQ.GLILASKTNWAEDPALRETVLQLE........
CENPH_CHICK/122-226              ...........................................................................LNWEIIQAHQQARVIRENL.NDIRRKRYFLKQAEGEKALRIFTTVRKKKEVVR.....................-MKIAEKLKFIHRNVQYERKVTTLVQNILQ.NIIVGCQINWAKDPSLRAIILQLE........
B6K0U9_SCHJY/99-224              .........................................cdaqstatvrqldtsplgllsllsrqadltkscl-------------QMLHRA.QEERDHGIRLSAMLQDTVAECSELYKRIQITSR....................kQEAASQSIGDVVTQYRQVRGRWEVLRNVVQ.TLVLESGVDWTDNPTIMDIM----sa......
C0S3I9_PARBP/140-248             ...........................................................................LSLIYENLSRAHASCIQTL.SDAKVENIQHNEKNQQMVQTLLGLTSAEKTWREe..................itDPKLRAQLETVEKECKAEQANWVTIKRIVS.AAIVASGIDWAEDEKLRDLVVDD-v.......
G7P7N4_MACFA/136-241             ...........................................................................LNKLIMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................SMENSDRIKIIRQNLQMEIKITTIIQHVFQ.NLILGSKVNWAEDPALKEIVLQLE........
A8WHV8_DANRE/126-229             ...........................................................................ICEKTIQILKETRELQDQI.TDVQKQRLDLKGQIKKKMQEINELKQEKENQGE.....................--VQQKTKERAEAVLQKYQRITTILQNVLR.GIILASKVNWREDPKLSDIVMKLE........
A1D6R3_NEOFI/129-237             ...........................................................................LSLTHENLMNAHNATLREL.SNVEVQNLQLHQKNQELARQLLESTKDDDSWREa..................ldDDDLKAQLEQLEADRKRSKSRWEVMKSVAS.AIVVGSGVNWAEDDELTALVIDE-s.......
F9G357_FUSOF/121-229             ........................................................................tsi---SVATQAAETNKVLSVL.TNVQSNTLRKSRENVTSAAEMLELAEQVKLKKRv..................ppNSKMMQEQEELEADVKASKQRWRVMKGVAS.GIIVGSGIDWVHDDELQDVVLD--pe......
C3YVM5_BRAFL/129-233             .......................................................................lvfe----LGKYHKDIQDLQENL.DRVKKDSFEQQVRNRELMTQVQQRKEGQQQRSQ.....................-DDSSDRVKMFESHLEQAMSKISSLQHIFQ.ALMIGSQVHWADDPDMEQLMISL-g.......
Q4P7V5_USTMA/156-297             ............................................deqkadqktyastrkllderddqaleflrvf----------------NQI.RSIKKQRIEVKARIREQRLETMKLLENIKAIKAdirsrqlrpaasgtqtsgaspDIVVVQKVQQMQREINEARSKKELVKGILR.GLIIESGRDWTKNASTRALMLSL-d.......
Q4WY32_ASPFU/129-237             ...........................................................................LSLAHENLMNAHNATLREL.SNLEVQNLELHQRNQELARQLLESAKDDDSWREa..................ldDDDLKAQLEQLEADRKKSKSRWEVMKSVAS.AIVVGSGVNWAEDDELTALVIDE-s.......
F2TJI4_AJEDA/137-245             ...........................................................................LSLIYTNLSRAHASCTQSL.STAKVDSIHSTAKNQKLVQTLLGLTSAQTSWREg..................itDQKLRSQLETLEKETKAEKANWVTIKRIVS.AAIVASGVDWAADEQLHDLVVDDD........
G4U9C1_NEUT9/131-240             ...........................................................................ISAEAAEQALASYQVRDHI.LDLELERLRVGQHNATLASELLRLSKTTGTHDVqv.................dgSTKLGRKLGKTKGELRVSRQKWKTIKGATS.ALVAGTGVDWARDERLRDLVLD--pp......
CENPH_BOVIN/133-238              ...........................................................................LNKLIMKSQQETWDLEEKL.LDVRKKRLQLKQASERKLLEIQTEKNKQKDDLD.....................SMENSDKIKAIQQNLETEIQITTVIQHVFQ.NLILGSKVNWAEDPALKETVLQLE........
F6RXE0_XENTR/138-243             ...........................................................................LSSSVMNLQQKEFKILNKIlISICIYYIVLKEQGSAKMLEIQTMKSNWKANRE.....................-EMKNEKIKRLHKVLKEEIDSVTVLQNVFQ.NIILASHVDWAKYPQLKDIVLRLE........
F2PHW1_TRIEC/131-239             ...........................................................................LSLAYENMLTTHTTCLRKL.SNAEVSNIQSIKQNQELVQSLLKLTSREKSADEe..................ipDLELKEELNSLKSENKQKKAQWTRIKRIVS.ASIAASGVDWASDEKLERLVLDDD........
E4UNM1_ARTGP/131-239             ...........................................................................LSLAYENILTTHTTCIREL.SNAEVSNIQSIKQNQELVQSLLKLTRNEKSADEe..................ipDQELKEELNSLISENKQKKAQWTRMKRIVS.ASIAASGVDWASDEKLERLVLDDD........
E9E019_METAQ/124-232             ........................................................................ain----VAKHATEVAFIRNDL.TQVQSDTARVIRRNVGLTSTLFELAEEVKQKQAsr.................ldDEETQSEIRQLEVAMMASRQRWRVIKGVAS.GIVAGSGVDWARDAKLREVVLDLD........
D2H2T8_AILME/1-56                ..........................................................................i-------------------.--------ELKQASESKLLEIQTEKNKQKDDLV.....................DMENSDKIKTIQQNLQMEIQITTVIQHVFQ.------------------------........
F2UDY6_SALS5/143-247             ...........................................................................LCSACLRLSDRYRDLTQEL.EMINADIRDTMLRNRQIYSDIQDLEQQLEAGTQ.....................-EPPSQALDNERQKLENEYVKNAILRNTLQ.LLIVASGVDWAADENLLETMLSL-d.......
G9NA91_HYPVG/112-220             ........................................................................tsi---SVAKQAESTTKLRRDL.TKVQVQSIRICRENVKLTEQLFELAEQAKQKAIr..................lnNPEVQREMDKLTREVKYSRQRWKVMKGVAS.GIIAGSGVDWAGDEDLRNIVLD--pe......
C5G7F8_AJEDR/137-245             ...........................................................................LSLIYTNLSRAHASCTQSL.STAKVDSLHSTAKNQKLVQTLLGLTSAQTSWREg..................itDQKLRSQLETLEKETKAEKANWVTIKRIVS.AAIVASGVDWAADEQLHDLVVDDD........
F2S7D6_TRIT1/131-239             ...........................................................................LSLAYENMLTTHTTCLRKL.SNAEVSNIQSIKQNQELVQSLLKLTSREKSADEe..................ipDLELKEELNSLKSENKQKKAQWTRIKRIVS.ASIAASGVDWASDEKLERLVLDDD........
F7GDG6_ORNAN/1-53                ..........................................................................m-------------------.---------------------------------.....................--EASDLLKRIKENVRKEIQMTVVIQNVFQ.NIIIGTQVNWAEDPALKNIVLQLE........
E6ZMG3_SPORE/160-297             dgdkqyastrkllderddqaleflrvfnetraikqqrvevkarireqrletmkqldtiktikadirtcqlhpsas-------------------.------------------------ARQDSDASQ.....................DLATVQKVQQVQREINEARSKKELVKGILR.GLILESGRDWTKNASTRALMLSL-d.......
C1C3S7_LITCT/86-189              .......................................................................vasl----TLKEQKESRSLEKQL.IDIREKRMALKEKSTALMTEVLSIVDELRFQKE.....................--PKEEKLKKIFKHVKRETDTTFMLQNIFQ.RLIHASRVNWVEDPKLREAVIK--ag......
G1QVE6_NOMLE/136-241             ...........................................................................LNKLIMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................GMENSERIKIIRQNLQMEIKITTVIQHVFQ.NLILGSKVNWAEDPALKEIVLQLE........
D8M956_BLAHO/140-245             .........................................................................lr--KEYERKLQENASLLEEN.QSLKAACDTLRGQIHEQETVLQEMEEKESKSVN.....................REKQQHELKIAISKYEVQRRQNEILRNIYS.SLVLASRIDWARKDRIREMML---cve.....
H0Y9E6_HUMAN/76-181              ...........................................................................LNKLIMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................SMENSERIKIIRQNLQMEIKITTVIQHVFQ.NLILGSKVNWAEDPALKEIVLQLE........
H0ZVC1_TAEGU/72-176              ...........................................................................LSQTIIDYQKKIHEKEQQL.INIRRERLSLKVYGGQKLQQIQTMMKRQKEKQA.....................-SMDVRKIEKMLANLEKEREMTTIIQNVFQ.NIIVGSKVNWAEDPSLKAIVLQL-g.......
E9C9D8_CAPO3/157-269             ...........................................................................LSTEALAWSQSVAAKHALL.HKLEQEAKVLRTANRELSATVRAHRQELDAMSApaa..............lgpaRHSAANKLHEARINFGLQRSRSRMVRNVFQ.ALVLESGVNWMDDPAFASLVLSLE........
H1V387_COLHI/121-230             ........................................................................asi---ALSKTSSDIRSAVDEL.TDVEAESLRVGRRNIELAAEVLRLAKETEMRRTge.................tdDPAVQAEMARLQVELKSSRQRWKVMKGTAS.AVVVGSGVDWARDEALTDIVLD--pe......
B6H4J5_PENCW/129-237             ...........................................................................LALAHENLASAHDLVLRQL.SNLEVKNLQINRENQELVRQLLELTKEDSSWREk..................leDHELLSQLDSLETDLKARKAQWETMKSIAS.AVVVASGLNWADDDMLRALVLDE-s.......
F7GYV6_MACMU/136-241             ...........................................................................LNKLIMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................SMENSDRIKIIRQNLQMEIKITTIIQHVFQ.NLILGSKVNWAEDPALKEIVLQLE........
G3W0S9_SARHA/97-202              ........................................................................vng---SILKAQQLTRDLEEKM.LEVKKKRLMFKKAGEEKVLEIKAEKKRKKDESS.....................LLNNSPLIIKMKKNLQKEIDTTVIIQNVFQ.HIVMAAKIDWAADPDLKALILQ--fe......
G9P907_HYPAI/116-225             ........................................................................tsi---SVAQHADSVAKLRDDL.TAVQVQSIRVCRQNMDLTSELFALAEQAKQKKAvr.................vdDPRVQQEIEKLTREVKTSRQRWRVMKGVAS.GVVAGSGVDWAKDEDLRNIVLD--pe......
G1L8V0_AILME/135-241             ...........................................................................LNKLIMKSHQESWDLEEKL.LDVRKKRLQLKQASESKLLEIQTEKNKQKDDLV.....................DMENSDKIKTIQQNLQMEIQITTVIQHVFQqNLILGSKANWAEDSAFKETVLQLE........
H0W563_CAVPO/104-199             ........................................................................ttk---EVLKLNKLHWKL-EEL.LDLRKKRLQLKLASESKLLETQTDFSKKEIQTE.....................KKQRSLTIKTMQQSLQMEMEITTVIR----.-----SEVNWAVDPALKESVLQL-k.......
C5P9N1_COCP7/133-240             ...........................................................................LSLVYENLAGVNNSCVENL.SNAEVSNIRAVKDNRDLVRSLLELTDGNAEEEEi...................kDLKSKEELETLKRENKNRRDEYMTMKRIVS.AVIVASGLDWASDEKLLTLVVEDE........
C4JZ24_UNCRE/132-239             ...........................................................................LSLAYENLASINSSCSERL.SNAEVDNIQTATENRDLVQSLLELTRGKDEKLQi...................eDPDLRSELETLERKTKKAKADYVTMKRIIS.ASIVASGIDWASDETLLKLVVDDE........
Q0CNP0_ASPTN/129-237             ...........................................................................LSLAHENLNAAQNSTLRKL.SDVEVENLQLHRKNKDLVQELLSLTKNDESWREk..................leDADLRAQLDQVRTDYKKSKAKWDTMKSVAS.AIVVGSGVNWAEDEDLLSLVLDE-s.......
E2R8X4_CANFA/139-244             ...........................................................................LNKLIMKSHQESWDLEEKL.LDVRKKRLELKQSSENKLLEIQTEKNKQKDDLA.....................NMENSNKIKAMQRNLKMEIQITTVIQNVFQqNLILGSK-AWAEDPTLKEIVLRLE........
C6HRL4_AJECH/137-245             ...........................................................................LSLIYVNLSRAHGSCTQSL.SNTKVDGMHGTAKTQELVQTLLGLTSAEKSRREa..................itDPALISQLEAQEKETKAERASWVTMKRVVS.ALIVASGIDWAADEALHDLVVDDE........
G2YBK7_BOTF4/126-235             ..........................................................................m-SETLAQISNQIQSSREEL.MRESNENIVTGRKNIELATEMLALAEEANSQGKen.................iqDPDVRAQLDELEGAMKNSRQRWRIMKNTAS.AVIVGSGIDWARDPKLLAIVLDDD........
H0WK59_OTOGA/135-240             ...........................................................................LNKLIMKSQQESWDLEEKL.VDVRKKRLELKQASESKLLEIQMEKNKQKNELD.....................SMENSDKVKTIQQNLQMEIQITTVVQHVFQ.NIILGSKVNWAENSALKETVLQLE........
B9EMR0_SALSA/129-233             ...........................................................................LCLKIKTLQQESCELQDQI.TDLKKQRLDLKRLTHEKMKEMDELKRKREHPEA.....................-EKYRNVLQKGQSHLEKYQKMATITQNVLR.GIIIASKVNWRDDPKLRDIAMTL-e.......
G2R207_THITE/121-227             .............................................................kvaslcadldsawg-----------------RL.AELETESLRATQRNMELASEVLRLAAGTNDKTPsq.................leGGRLEMELAGHEAEMKSNRRRWRIMKGAAS.AIVAGSGIDWVRDERLRDLVLDL-p.......
H2QR06_PANTR/136-241             ...........................................................................LNKLIMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTKKNKQKIDLD.....................SMENSERIKIIRQNLQMEIKITTVIQHVFQ.NLILGSKVNWAEDPALKEIVLQLE........
C1G1C0_PARBD/76-184              ...........................................................................LSLIYENLSRAHASCIQTL.SDAKVENIQHNEKNQQMVQTLLGLTSAEKTWREe..................itDPKLRAQLETVEKECKAEQANWVTIKRIVS.AAIVASGIDWAEDEKLRDLVVDD-v.......
A2QDK2_ASPNC/74-182              ...........................................................................LSLAHENLNTAHNATLRRL.SSLEVENSQIHQQNQELVRELLALTVDDESWREn..................leDAELKAQLDQLDADRRKSKAKWETMKNIAS.GMVVGSGVNWAEDERLTALVLDE-s.......
F2SW09_TRIRC/131-239             ...........................................................................LSLAYENMLTTYTTCIRKL.SSTEVSNIQNIKQNQELVQSLLKLTNSEKSADEe..................ipDLELKEELNSLKSENKQKKAQWTRIKRIVS.ASVAASGVDWASDEKLERLVLDDD........
Q0UIN8_PHANO/130-239             .....................................................................vsmvhg------SLTSKLVSTQRTI.NTAAQANIVASRKNRELAAEMLALAEDMKAQSAkd.................ieDPRLRDQVSAVEKELRESRRRAKTLKGVLS.AMVVGSGINWAADEGLTELVMDDE........
H2PFR2_PONAB/136-241             ...........................................................................LNKLIMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................SMENSERIKIIRQNLQMEIKITTVIQHVFQ.NLILGSKVNWAEDPALKEIVLQLE........
G5B8V0_HETGA/131-236             ....................................................................lklnksv-------MKQESWELEEKL.LDVRKKRFQLKQASESKLLEIETEKKKRKEELG.....................SMENSDKIKTMKQSLQRERQIATVIQHVFQ.NLILGSKVNWAADPALKETVLELE........
F1M389_RAT/131-236               ...........................................................................LQKLIMKSQEESKELEKKL.LDVRKKRLQLKQASRSKLLEIQTERNKQKEDVD.....................KMENSEVVKAMKDKLQLEIKITTVIQHAFQ.GLILGSKTNWAEDPTLRELVLQLE........
G1PLH1_MYOLU/94-199              ...........................................................................LNKIIMKLQQESWDLEEKL.LDVKKKRFELKRASESKFLEIQTEKNKEKDALA.....................SMENSDKIKTLQQKLQKEIQITTVIQHVFQ.NLILGSKVNWAEDSAFKETVLQLE........
F7HY65_CALJA/136-242             ...........................................................................LNKLVMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................GMENSERIKIIRQNLQMEIKITTVIQHVFQqNLILGSKVNWAEDPALKETVLQLE........
I1RA59_GIBZE/121-230             .........................................................................as--VSVARQASQTNEVWKAL.TTAQSDTLRKSRENVTLAAELFELADQAKLKKRvp.................pnNSKMMEEQKRLEAEVKASKQKWRVMKGVAG.GIIVGSGVDWVQDDELRDVVLD--pe......
C9SMQ0_VERA1/27-143              .........................................................................as--ATLARNATNLRDTLDAL.AATRAGALAAGRRNAELAQEVLRLAEEAARRRDggsep..........qggggeDDEARREMQLLRAGLKASRQKWKVMKGTAS.AIVVGSGVDWVGDEGLRWMVLD--pe......
A6QRL1_AJECN/109-208             ..................................................................dpsiqsvhs------------------I.TDSPAESMQGTAKTQESVQTLLGLTSVEKSRREa..................itDPALISQLEAQEKETKAERASWVTMKRVVS.ALIVASGIDWAADEGLHDLVVDDE........
G1KSK7_ANOCA/91-196              ...........................................................................LSTAILQSEQQSRELEEKL.NEVKRSRIALKRAGECKLAQIRDIKRKRKAELE.....................NMKVGEILEKVHGDLQKKIKITTIVQNVFQ.NIIFASKVNWEEDSDLKAIVLQLE........
A1CKR0_ASPCL/129-237             ...........................................................................LSLAYENLTTADNATLREL.SNVEVQNLQLNQRNQELVGQLLDMTKDDMSWREd..................lqDEDLRAQLEELESERRKSRARWETMKSIAS.AIVVGSGVNWAEDDSLTALVLDE-h.......
C3YVL8_BRAFL/24-107              .........................................................satstisnksvysettpt-------------------.------------------------PSQDKQGVEe..................egDVTELVELKGFESHLEQAMSKISSLQHIFQ.ALMIGSQVHWAEDPDMEQLMISL-g.......
E5A8D5_LEPMJ/50-159              .....................................................................vsmvhg------AQTTKLASVTRAL.STAEQANMIANRKNRELAQRMLALAEDMKAQSVkd.................ieDPQLRAQVDAVEKALKESRRRKKTVKGILS.AMIVGSGIHWAADAELTELVMDDD........
Q2UKQ1_ASPOR/157-265             ...........................................................................LSLAHENLNTALSSTLKKL.SNAEVENLQLHQKNKALVRELLDLTKNDESWREe..................ldDMSIKELLEQVKADHKRSKAKWETMKSITS.AIVVGSGVNWAEDEELVALVLDD-s.......
#=GC seq_cons                    ...........................................................................ls..h.p.tptptsh.ccL.tslchcplplpppspphhtclhplppcpcpppc.....................s.chppplcplcpphctp+pphpsl+plhp.ullluSGVsWAcDtpL+clVLc..........
//
DBGET integrated database retrieval system