#=GF ID CENP-H
#=GF AC PF05837.7
#=GF DE Centromere protein H (CENP-H)
#=GF AU Moxon SJ
#=GF SE Pfam-B_8705 (release 8.0)
#=GF GA 23.00 23.00;
#=GF TC 25.30 25.00;
#=GF NC 22.90 22.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF WK CENPH
#=GF RN [1]
#=GF RM 10488063
#=GF RT Characterization of a novel kinetochore protein, CENP-H.
#=GF RA Sugata N, Munekata E, Todokoro K;
#=GF RL J Biol Chem 1999;274:27343-27346.
#=GF RN [2]
#=GF RM 11500386
#=GF RT CENP-H, a constitutive centromere component, is required for
#=GF RT centromere targeting of CENP-C in vertebrate cells.
#=GF RA Fukagawa T, Mikami Y, Nishihashi A, Regnier V, Haraguchi T,
#=GF RA Hiraoka Y, Sugata N, Todokoro K, Brown W, Ikemura T;
#=GF RL EMBO J 2001;20:4603-4617.
#=GF DR INTERPRO; IPR008426;
#=GF CC This family consists of several eukaryotic centromere protein H
#=GF CC (CENP-H) sequences. Macromolecular centromere-kinetochore
#=GF CC complex plays a critical role in sister chromatid separation,
#=GF CC but its complete protein composition as well as its precise
#=GF CC dynamic function during mitosis has not yet been clearly
#=GF CC determined. CENP-H contains a coiled-coil structure and a
#=GF CC nuclear localisation signal. CENP-H is specifically and
#=GF CC constitutively localised in kinetochores throughout the cell
#=GF CC cycle. CENP-H may play a role in kinetochore organisation and
#=GF CC function throughout the cell cycle [1]. This the C-terminus of
#=GF CC the region, which is conserved from fungi to humans.
#=GF SQ 119
#=GS G3QGP4_GORGO/136-241 AC G3QGP4.1
#=GS Q0P4K1_XENTR/138-242 AC Q0P4K1.1
#=GS E3QDF7_COLGM/121-230 AC E3QDF7.1
#=GS F8MZG8_NEUT8/96-205 AC F8MZG8.1
#=GS C1BYA2_ESOLU/126-230 AC C1BYA2.1
#=GS B3KVZ3_HUMAN/117-222 AC B3KVZ3.1
#=GS F0ZEI0_DICPU/172-273 AC F0ZEI0.1
#=GS Q5B994_EMENI/128-236 AC Q5B994.1
#=GS F0U813_AJEC8/137-245 AC F0U813.1
#=GS B8M4Y6_TALSN/133-241 AC B8M4Y6.1
#=GS F7IJ38_CALJA/117-222 AC F7IJ38.1
#=GS F6PLT4_HORSE/135-240 AC F6PLT4.1
#=GS FTA3_SCHPO/111-209 AC O94261.1
#=GS F7BNS0_XENTR/136-239 AC F7BNS0.1
#=GS D4DK94_TRIVH/131-239 AC D4DK94.1
#=GS G4MS99_MAGO7/125-236 AC G4MS99.1
#=GS A6RR02_BOTFB/100-208 AC A6RR02.1
#=GS C5JUC6_AJEDS/137-245 AC C5JUC6.1
#=GS A7RSC2_NEMVE/135-240 AC A7RSC2.1
#=GS F7HY66_CALJA/136-241 AC F7HY66.1
#=GS D4B356_ARTBC/131-239 AC D4B356.1
#=GS C5FS81_ARTOC/123-231 AC C5FS81.1
#=GS B6Q331_PENMQ/133-241 AC B6Q331.1
#=GS G2WZ89_VERDV/119-235 AC G2WZ89.1
#=GS C1GTZ3_PARBA/76-184 AC C1GTZ3.1
#=GS B2AM45_PODAN/106-215 AC B2AM45.1
#=GS C3KH67_ANOFI/127-231 AC C3KH67.1
#=GS G2Q1Y8_THIHA/109-217 AC G2Q1Y8.1
#=GS E9CYZ8_COCPS/133-240 AC E9CYZ8.1
#=GS A7E7B6_SCLS1/121-230 AC A7E7B6.1
#=GS F9GGB7_FUSOF/38-122 AC F9GGB7.1
#=GS G1X4K7_ARTOA/147-251 AC G1X4K7.1
#=GS C0NUZ1_AJECG/137-245 AC C0NUZ1.1
#=GS G3J8R7_CORMM/141-242 AC G3J8R7.1
#=GS Q6CEC4_YARLI/129-231 AC Q6CEC4.1
#=GS G5BKN6_HETGA/97-202 AC G5BKN6.1
#=GS G3Y3L7_ASPNA/131-239 AC G3Y3L7.1
#=GS B0XXC4_ASPFC/129-237 AC B0XXC4.1
#=GS F0XUY0_GROCL/183-294 AC F0XUY0.1
#=GS Q7S057_NEUCR/96-205 AC Q7S057.1
#=GS B8N1N6_ASPFN/129-237 AC B8N1N6.1
#=GS B7FSK2_PHATC/135-244 AC B7FSK2.1
#=GS Q4RUR4_TETNG/31-135 AC Q4RUR4.1
#=GS G0RDU4_HYPJQ/122-231 AC G0RDU4.1
#=GS F7W180_SORMK/114-223 AC F7W180.1
#=GS H2LZ13_ORYLA/11-41 AC H2LZ13.1
#=GS E9EWB2_METAR/125-233 AC E9EWB2.1
#=GS G7XPL2_ASPKW/129-237 AC G7XPL2.1
#=GS H0VRH0_CAVPO/1-97 AC H0VRH0.1
#=GS E3RR68_PYRTT/165-268 AC E3RR68.1
#=GS F6QC79_MONDO/96-201 AC F6QC79.1
#=GS CENPH_HUMAN/136-241 AC Q9H3R5.1
#=GS H3IHD5_STRPU/160-262 AC H3IHD5.1
#=GS B2WEL0_PYRTR/131-236 AC B2WEL0.1
#=GS CENPH_MOUSE/130-235 AC Q9QYM8.1
#=GS CENPH_CHICK/122-226 AC Q90ZF9.1
#=GS B6K0U9_SCHJY/99-224 AC B6K0U9.1
#=GS C0S3I9_PARBP/140-248 AC C0S3I9.1
#=GS G7P7N4_MACFA/136-241 AC G7P7N4.1
#=GS A8WHV8_DANRE/126-229 AC A8WHV8.1
#=GS A1D6R3_NEOFI/129-237 AC A1D6R3.1
#=GS F9G357_FUSOF/121-229 AC F9G357.1
#=GS C3YVM5_BRAFL/129-233 AC C3YVM5.1
#=GS Q4P7V5_USTMA/156-297 AC Q4P7V5.1
#=GS Q4WY32_ASPFU/129-237 AC Q4WY32.1
#=GS F2TJI4_AJEDA/137-245 AC F2TJI4.1
#=GS G4U9C1_NEUT9/131-240 AC G4U9C1.1
#=GS CENPH_BOVIN/133-238 AC Q3T0L1.1
#=GS F6RXE0_XENTR/138-243 AC F6RXE0.1
#=GS F2PHW1_TRIEC/131-239 AC F2PHW1.1
#=GS E4UNM1_ARTGP/131-239 AC E4UNM1.1
#=GS E9E019_METAQ/124-232 AC E9E019.1
#=GS D2H2T8_AILME/1-56 AC D2H2T8.1
#=GS F2UDY6_SALS5/143-247 AC F2UDY6.1
#=GS G9NA91_HYPVG/112-220 AC G9NA91.1
#=GS C5G7F8_AJEDR/137-245 AC C5G7F8.1
#=GS F2S7D6_TRIT1/131-239 AC F2S7D6.1
#=GS F7GDG6_ORNAN/1-53 AC F7GDG6.1
#=GS E6ZMG3_SPORE/160-297 AC E6ZMG3.1
#=GS C1C3S7_LITCT/86-189 AC C1C3S7.1
#=GS G1QVE6_NOMLE/136-241 AC G1QVE6.1
#=GS D8M956_BLAHO/140-245 AC D8M956.1
#=GS H0Y9E6_HUMAN/76-181 AC H0Y9E6.1
#=GS H0ZVC1_TAEGU/72-176 AC H0ZVC1.1
#=GS E9C9D8_CAPO3/157-269 AC E9C9D8.1
#=GS H1V387_COLHI/121-230 AC H1V387.1
#=GS B6H4J5_PENCW/129-237 AC B6H4J5.1
#=GS F7GYV6_MACMU/136-241 AC F7GYV6.1
#=GS G3W0S9_SARHA/97-202 AC G3W0S9.1
#=GS G9P907_HYPAI/116-225 AC G9P907.1
#=GS G1L8V0_AILME/135-241 AC G1L8V0.1
#=GS H0W563_CAVPO/104-199 AC H0W563.1
#=GS C5P9N1_COCP7/133-240 AC C5P9N1.1
#=GS C4JZ24_UNCRE/132-239 AC C4JZ24.1
#=GS Q0CNP0_ASPTN/129-237 AC Q0CNP0.1
#=GS E2R8X4_CANFA/139-244 AC E2R8X4.1
#=GS C6HRL4_AJECH/137-245 AC C6HRL4.1
#=GS G2YBK7_BOTF4/126-235 AC G2YBK7.1
#=GS H0WK59_OTOGA/135-240 AC H0WK59.1
#=GS B9EMR0_SALSA/129-233 AC B9EMR0.1
#=GS G2R207_THITE/121-227 AC G2R207.1
#=GS H2QR06_PANTR/136-241 AC H2QR06.1
#=GS C1G1C0_PARBD/76-184 AC C1G1C0.1
#=GS A2QDK2_ASPNC/74-182 AC A2QDK2.1
#=GS F2SW09_TRIRC/131-239 AC F2SW09.1
#=GS Q0UIN8_PHANO/130-239 AC Q0UIN8.2
#=GS H2PFR2_PONAB/136-241 AC H2PFR2.1
#=GS G5B8V0_HETGA/131-236 AC G5B8V0.1
#=GS F1M389_RAT/131-236 AC F1M389.1
#=GS G1PLH1_MYOLU/94-199 AC G1PLH1.1
#=GS F7HY65_CALJA/136-242 AC F7HY65.1
#=GS I1RA59_GIBZE/121-230 AC I1RA59.1
#=GS C9SMQ0_VERA1/27-143 AC C9SMQ0.1
#=GS A6QRL1_AJECN/109-208 AC A6QRL1.1
#=GS G1KSK7_ANOCA/91-196 AC G1KSK7.1
#=GS A1CKR0_ASPCL/129-237 AC A1CKR0.1
#=GS C3YVL8_BRAFL/24-107 AC C3YVL8.1
#=GS E5A8D5_LEPMJ/50-159 AC E5A8D5.1
#=GS Q2UKQ1_ASPOR/157-265 AC Q2UKQ1.1
G3QGP4_GORGO/136-241 ...........................................................................LNKLIMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................SMENSERIKIIRQNLQMEIKITTVIQHVFQ.NLILGSKVNWAEDPALKEIVLQLE........
Q0P4K1_XENTR/138-242 ...........................................................................LSSSVMNLQQETRDLEEKM.YDIRKKRLVLKEQGSAKMLEIQTMKSNWKANRE.....................-EMKNEKIKRLHKVLKEEIDSVTVLQNVFQ.NIILASHVDWAKYPQLKDIVLRLE........
E3QDF7_COLGM/121-230 ......................................................................tsvtl-----SETSSDIRAAINEL.TEVEAESLRVGRRNVELTAEILRLTEEAEARRMge.................tgDFGVQGDMYRLQAEVKASRQRWKVMKGTAS.AIVVGSGIDWTRDEALTDIVLD--pe......
F8MZG8_NEUT8/96-205 ...........................................................................ISAEAAEQASASYQVRDHI.LDLELERLRVGQHNATLASELLRLSKTTGTHNVqv.................dgSTKLGRKLGKTKGELRVSRQKWKTIKGATS.ALVAGTGVDWARDERLRDLVLD--pp......
C1BYA2_ESOLU/126-230 ...........................................................................LCLKIKTLQQESFELQDQI.TALQKQRLDLKRLTHEKMKEMEELKTKGEHPVA.....................-EEYRNVLQKAQSYLEKYQKMVAIEQNVLR.GIIIASKVNWREDPKLREIAMTL-e.......
B3KVZ3_HUMAN/117-222 ...........................................................................LNKLIMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................SMENSERIKIIRQNLQMEIKITTVIQHVFQ.NLILGSKVNWAEDPALKEIVLQLE........
F0ZEI0_DICPU/172-273 ............................................................lklskirdegveicl----------------KLI.SQIELNNDEILKIRKKRIEEMK-LNRETYNNLKm...................kLEESKSKTEREQKNYSVLKDKTSLLGFIIQ.NLVYESGIDWVKDDEIT-------yff.....
Q5B994_EMENI/128-236 ...........................................................................LSLALENFTEAQASTLKKL.SSLEVENLQLHRQNQELVRELLELTEDDESWREq..................ldDPELKQQLEQLEAEHKQSKAKWETMKSVAS.AIIVGSGVDWAEDEDLTALVLDD-l.......
F0U813_AJEC8/137-245 ...........................................................................LSLIYVNLSRAHGSCTQSL.SNTKVDGMHGTAKTQELVQTLLGLTSAEKSRREa..................itDPALISQLEAQEKETKAERASWVTMKRVVS.ALIVASGIDWAADEALHDLVVDDE........
B8M4Y6_TALSN/133-241 ...........................................................................LSLVYENLANARTATVEAL.SNAEVENLRLMEQNKGLASELLELTAQETSWRDr..................vdDEALIARMEEIEQEYKKTRAQRDTIKSVLS.ALVVGSGVDWARDDRLRDSVLEE-l.......
F7IJ38_CALJA/117-222 ...........................................................................LNKLVMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................GMENSERIKIIRQNLQMEIKITTVIQHVFQ.NLILGSKVNWAEDPALKETVLQLE........
F6PLT4_HORSE/135-240 ...........................................................................LNKLIMKSQQESWDLEEKL.LDVRKKRLQLKQASESKLLEIQTEKNKQKDDLD.....................SMENSDKIKTIQQNLQMEIQITTVIQHVFQ.NLILGSKANWAEDSAFKETVLQLE........
FTA3_SCHPO/111-209 ...........................................................................LSEENLKIESSITFTSEEI.EKEKENIKSVLLPSVQSISSSLELYASKESDYR.....................-----SSIEGVLADLKLARARWEIVRNVTQ.ILLLESGISFLENKKLAYIM----dl......
F7BNS0_XENTR/136-239 ..........................................................................i-CKMIQAVQSSNRILEEKL.ASVRKSRMEVRLLQQELFKKVKITEERKNKLQE.....................-IEMKTQVV-GKENMDTVANKVIIIQEIFQ.RCILSTHTDWSEDPHLTRLLLK--mk......
D4DK94_TRIVH/131-239 ...........................................................................LSLAYENMLSTHTTCLRKL.SSAEVSNIQNIKQNQELVQSLLKLTSNDKSADEe..................ipDLELKEELNRLKSENKQKKAQWTRIKRIVS.ASIAASGVDWASDEKLESLVLDDD........
G4MS99_MAGO7/125-236 .........................................................................as--IAVANQTTALHETLDKL.TSVEADSLALSRKNVELAAEMLDLVQEHEARRKgvt...............adeDPDTAAEIRRLEGQVQASRRRWRIMKGTAG.AVVVGSGVDWVGDPVLRDVVLDS-e.......
A6RR02_BOTFB/100-208 ...................................................................lkavhags---------NASIMEQEEL.MRESNENIVTGRKNIELATEMLALAEEANSQGKen.................iqDPDVRAQLDELEGAMKNSRQRWRIMKNTAS.AVIVGSGIDWARDPKLLALVLDDD........
C5JUC6_AJEDS/137-245 ...........................................................................LSLIYTNLSRAHASCTQSL.STAKVDSIHSTAKNQKLVQTLLGLTSAQTSWREg..................itDQKLRSQLETLEKETKAEKANWVTIKRIVS.AAIVASGVDWAADEQLHDLVVDDD........
A7RSC2_NEMVE/135-240 ...........................................................................LCSEILRQHQAMLETQQEL.DQVKQQSLAMKKRNRELMAKLKDLQRRQSQGEH.....................NSSEVEAIAKAKDGLNDSKRKLRVVGNIFQ.GLIVGSGINWAADDSLRQLMIEL-g.......
F7HY66_CALJA/136-241 ...........................................................................LNKLVMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................GMENSERIKIIRQNLQMEIKITTVIQHVFQ.NLILGSKVNWAEDPALKETVLQLE........
D4B356_ARTBC/131-239 ...........................................................................LSLAYENMLTTHTTCLRKL.SSAEVSNIQNIKQNQELVQSLLKLTSSEKSADEe..................ipDLELKEELNSLKSENKQKKAQWTRIKRIVS.ASIAASGVDWASDEKLERLVLDDD........
C5FS81_ARTOC/123-231 ...........................................................................LSLAYENIMTSHTACIREL.SSAEVANIQSIQKNQELVQTLLELTRNEKSLDDn..................isDPQLKEELDSLRTENKQKKAHWTRIKRIVS.ASIAASGVDWASDEKLENLVLDDD........
B6Q331_PENMQ/133-241 ...........................................................................LSLVYENLVNARTTTVEAL.SNAEVENLRLMEQNKGLASELLELTAQETLWRDr..................idDEAVIAQMEDIEQEYKKTRARRDTIKSVIS.ALVVGSGVDWARDDRLRSLVLDE-l.......
G2WZ89_VERDV/119-235 .........................................................................as--ATLARNATSLRDTLDAL.AATRAKALSAGRRNAELAQEVLRLAEEAARRRGggsgp..........kgsggeDDETRRETQLLRAGLKASRQKWKVMKGTAS.AIVVGSGVDWVGDEGLRWMVLD--pe......
C1GTZ3_PARBA/76-184 ...........................................................................LSLIYENLSRAHASCIQTL.SDAKVENIQHNEKNQQMVQTLLGLTSAEKTWREe..................itDPKLRAQLETVEKECKAEQANWVTIKRIVS.AAIVASGIDWAEDEKLCDLVVDD-v.......
B2AM45_PODAN/106-215 ...................................................................aakrtaeh--------CSALHSAMERL.TKVEVEYLETKQRNVELASETLDLAADNVGQEPnn.................viNTQLKMELDTLETQLRATRGKWRVMKGTAS.AIVAGSGLDWVRDERLRELVLD--id......
C3KH67_ANOFI/127-231 ...........................................................................LCSQIKQLQQESRDLQDGI.TEVQKKRLEMKRLTHEKMKEMDELMSKTGHPDT.....................-EKYRAVLEKGQANLEKYKKMTVMTQNVLR.GILLACKVNWLDDPKLRDIAMTL-g.......
G2Q1Y8_THIHA/109-217 ........................................................................aat---KAANIYSELQTARARL.AELEVGSLKASHWNRELAADVLQLASENHKQDFes.................iqNGRFGSGIADLESQVKSSRHRWRIIKGATS.AIIAGSGIDWVRVKRLRELVLD--p.......
E9CYZ8_COCPS/133-240 ...........................................................................LSLVYENLAGVNNSCVENL.SNAEVSNIRAVKDNRDLVRSLLELTDGNAEEEEi...................kDLKSKEELETLKRENKNRRDEYMTMKRIVS.AVIVASGLDWASDEKLLTLVVEDE........
A7E7B6_SCLS1/121-230 ...........................................................................LSENLAQVSNNLQSSREEL.MKESNENIITGRKNVELATEMMVLAEEASSQGKen.................iqDPEVRAQLDELEAAMKNSRQRWRIMKNTAS.AVVVGSGVDWARDPKLLEIVLDDD........
F9GGB7_FUSOF/38-122 ....................................................................enkkiek------DFQLSINEVRLKL.SDLTGQRSQLKESQSRLARELAKVEAKLSRTTD....................eCQEKVSQLGRIEQDYHASRKKRT-------.------------------------etlhdiwf
G1X4K7_ARTOA/147-251 .......................................................................latt----LIHLTSQLSTLQEAH.NRSSAKLTSLTKSNKSLAEQLKQLSLEHEISEN.....................-ITTNEKLIAAKEETMKAQRQCRTLKGVLQ.GIIAGSGVDWAEDDVLRELVLE--cg......
C0NUZ1_AJECG/137-245 ...........................................................................LSLIYVNLSRAHASCTQSL.SNTKVDSMHGTAKTQELVQTLLGLTSAEKSRREa..................itDPALISQLEAQEKETKAERASWVTMKRVVS.ALIVASGIDWAADEALHDLVVDDE........
G3J8R7_CORMM/141-242 ........................................................................avd----AARSATQAQATRDAL.TDVQVETLRACRRNVQLTSRVFELAAQLEARKA.....................---VDWDGGEEALRVRDEKRKWRAVKGAAS.GIVAGSGVDWASDEALRDMVLD--pe......
Q6CEC4_YARLI/129-231 ..........................................................................k-SRDLLDSLIVVTGLRKQL.DVLICENRASLDTQRSIVRSIEKANDKSADRHQ.....................---NNQAISELEAKLHNTKNKRRVLAEIFT.ALITASGIDWCEDEDLVQLIVG--ag......
G5BKN6_HETGA/97-202 ...........................................................................LNKSVMKLQQESWELEEKL.LDVRKKRFQLKQASESKLLEIQTEKKKQKEELA.....................SMENSDKIKTMKQSLQREIQIATVIQHVFQ.NLILGSKVNWAADPALKETVLELE........
G3Y3L7_ASPNA/131-239 ...........................................................................LSLAHENLNTAHNATLRRL.SSLEVENSQIHQQNQELVRELLALTVDDESWREn..................leDAELKAQLDQLDADRRKSKAKWETMKNIAS.GMVVGSGVNWAEDERLTALVLDE-s.......
B0XXC4_ASPFC/129-237 ...........................................................................LSLAHENLMNAHNATLREL.SNLEVQNLELHQRNQELARQLLESAKDDDSWREa..................ldDDDLKAQLEQLEADRKKSKSRWEVMKSVAS.AIVVGSGVNWAEDDELTALVIDE-s.......
F0XUY0_GROCL/183-294 ..........................................................................a-SQAVAQQAGARRAVLERH.VAVAAESCRVRRQNQALAEQLHRQLAEAVEDDSagg...............dknNDTHDDELTQLQQELKASRQRWKLIKGTAS.AVVVGSGVDWARDPELQNLVLD--pe......
Q7S057_NEUCR/96-205 ...........................................................................ISAEAAEQASASYQVRDHI.LDLELERLRVGQHNATLASELLRLSKTTGTHDVqv.................dgSTKLGRKLGKTKGELRVSRQKWKTIKGATS.ALVAGTGVDWARDERLRDLVLD--pp......
B8N1N6_ASPFN/129-237 ...........................................................................LSLAHENLNTALSSTLKKL.SNAEVENLQLHQKNKALVRELLDLTKNDESWREe..................ldDMSIKELLEQVKADHKRSKAKWETMKSITS.AIVVGSGVNWAEDEELVALVLDD-s.......
B7FSK2_PHATC/135-244 .......................................................................ddll-------LQQAQQVCQRQV.QRALEKSRELEQVQQDVMTATEDSRRMQTESRScwe..............slvrEGEDDVVISNASTKESKDERQLRVLGRVLV.DLVTSSNIDWYEDDKLQEIMQ---rle.....
Q4RUR4_TETNG/31-135 ...........................................................................LCSHIKQLQQESRELQDEI.IDIQKRRLEMKRLTHEKIKEMEELMAKKEPPDS.....................-QKYKAALEKGQSNLEKYKKMAVMTQNVLR.GIILACKINWMDDPKLRDIAMSLE........
G0RDU4_HYPJQ/122-231 ........................................................................tsi---SVAKHADSMAKLRRDL.ASVQVQSIRVCRENVKLTAQVFELAEQAKQRKAvr.................ldDPDVQREMDKLTREVKASRQRWKVMKGVAS.GIVAGSGVDWAADEELRNIVLD--pe......
F7W180_SORMK/114-223 ..........................................................................v-SAKAAQQASASYEVRDRM.LTLELNRIRVGQQNATLASELLRLSKTTGATDVev.................dgATKLQRQLDKTKGELQVSRQRWKTIKGATS.VLVAGSGVDWVRDERLRGLVLD--pp......
H2LZ13_ORYLA/11-41 .....................................................................nvllsh-------------------.---------------------------------.....................-----------------------------Q.GLLLACKINWLDDPKLRHVAMTLE........
E9EWB2_METAR/125-233 ........................................................................ain----VAKHATEVAFIRNDL.TEVQSDTARVIRRNVDLTSTLFELAEEVKQKQAsr.................ldDEETQSEIRQLEVAMRASRQRWRVIKGVAS.GIVAGSGVDWARDAKLREVVLDLD........
G7XPL2_ASPKW/129-237 ...........................................................................LSLAHENLNTAHSATLRRL.ASLEVENSQIHRQNQELVRELLALTEDDESWREn..................leDAELKAQLDQLDADRRKSKAKWETMKNIAS.GMVVGSGVNWAEDERLTALVLDE-s.......
H0VRH0_CAVPO/1-97 ...........................................................................---------QESWELEEKL.LDIRKKRLQLKHASENKLLEIQTEKKKRKEELN.....................SMGNSDKIKTMQQILQTEMEIATVIQHVFQ.NIILGSKVNWAADPALKETVLQLE........
E3RR68_PYRTT/165-268 .......................................................................lets----------KLAGVRRAL.SVAEQGNILAKQKNRELAQTMVALAEEMKKQSAqd.................ieDAQLRQRVEGVEKEVKESRRRVRTVRGMLS.AMVVGSGINWAADEALTELVMDDE........
F6QC79_MONDO/96-201 ...........................................................................LNSSILKAQQETHDLEEKL.LEVKKKRLRLKQAGEEKLLEIQAEDKKKKEKLE.....................LLEDSALLSKLKKNLQREIESTTVIQNVFQ.HIIIATKIDWASDPDLKVLVLQLE........
CENPH_HUMAN/136-241 ...........................................................................LNKLIMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................SMENSERIKIIRQNLQMEIKITTVIQHVFQ.NLILGSKVNWAEDPALKEIVLQLE........
H3IHD5_STRPU/160-262 ...........................................................................LSSDILAHLNACQSLQDDV.DQGKKDIRDIQAGNVELMKKLQSRESADKMNDT.....................---PSNSVQRQQEKLDDLISHITMEKGILQ.GLIIGSGVNWAKDPALKEVVIGL-g.......
B2WEL0_PYRTR/131-236 .....................................................................hglets----------KLAAVTRTL.SVAEQGNIAAKQKNRELAQTMLALAEEMKKQSAqd.................iqDAQLRQRVDAVEKEVKESRRRVSTLKGILS.AMVVGSGINWAADEALTELVMDDE........
CENPH_MOUSE/130-235 ...........................................................................LQKLIMKSQEESSELEKKL.LDVRKKRLQLKQASRSKLLEIQIEKNKQKEDVD.....................KMENSEMIKTMKKKLQTEIKITTVVQHTFQ.GLILASKTNWAEDPALRETVLQLE........
CENPH_CHICK/122-226 ...........................................................................LNWEIIQAHQQARVIRENL.NDIRRKRYFLKQAEGEKALRIFTTVRKKKEVVR.....................-MKIAEKLKFIHRNVQYERKVTTLVQNILQ.NIIVGCQINWAKDPSLRAIILQLE........
B6K0U9_SCHJY/99-224 .........................................cdaqstatvrqldtsplgllsllsrqadltkscl-------------QMLHRA.QEERDHGIRLSAMLQDTVAECSELYKRIQITSR....................kQEAASQSIGDVVTQYRQVRGRWEVLRNVVQ.TLVLESGVDWTDNPTIMDIM----sa......
C0S3I9_PARBP/140-248 ...........................................................................LSLIYENLSRAHASCIQTL.SDAKVENIQHNEKNQQMVQTLLGLTSAEKTWREe..................itDPKLRAQLETVEKECKAEQANWVTIKRIVS.AAIVASGIDWAEDEKLRDLVVDD-v.......
G7P7N4_MACFA/136-241 ...........................................................................LNKLIMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................SMENSDRIKIIRQNLQMEIKITTIIQHVFQ.NLILGSKVNWAEDPALKEIVLQLE........
A8WHV8_DANRE/126-229 ...........................................................................ICEKTIQILKETRELQDQI.TDVQKQRLDLKGQIKKKMQEINELKQEKENQGE.....................--VQQKTKERAEAVLQKYQRITTILQNVLR.GIILASKVNWREDPKLSDIVMKLE........
A1D6R3_NEOFI/129-237 ...........................................................................LSLTHENLMNAHNATLREL.SNVEVQNLQLHQKNQELARQLLESTKDDDSWREa..................ldDDDLKAQLEQLEADRKRSKSRWEVMKSVAS.AIVVGSGVNWAEDDELTALVIDE-s.......
F9G357_FUSOF/121-229 ........................................................................tsi---SVATQAAETNKVLSVL.TNVQSNTLRKSRENVTSAAEMLELAEQVKLKKRv..................ppNSKMMQEQEELEADVKASKQRWRVMKGVAS.GIIVGSGIDWVHDDELQDVVLD--pe......
C3YVM5_BRAFL/129-233 .......................................................................lvfe----LGKYHKDIQDLQENL.DRVKKDSFEQQVRNRELMTQVQQRKEGQQQRSQ.....................-DDSSDRVKMFESHLEQAMSKISSLQHIFQ.ALMIGSQVHWADDPDMEQLMISL-g.......
Q4P7V5_USTMA/156-297 ............................................deqkadqktyastrkllderddqaleflrvf----------------NQI.RSIKKQRIEVKARIREQRLETMKLLENIKAIKAdirsrqlrpaasgtqtsgaspDIVVVQKVQQMQREINEARSKKELVKGILR.GLIIESGRDWTKNASTRALMLSL-d.......
Q4WY32_ASPFU/129-237 ...........................................................................LSLAHENLMNAHNATLREL.SNLEVQNLELHQRNQELARQLLESAKDDDSWREa..................ldDDDLKAQLEQLEADRKKSKSRWEVMKSVAS.AIVVGSGVNWAEDDELTALVIDE-s.......
F2TJI4_AJEDA/137-245 ...........................................................................LSLIYTNLSRAHASCTQSL.STAKVDSIHSTAKNQKLVQTLLGLTSAQTSWREg..................itDQKLRSQLETLEKETKAEKANWVTIKRIVS.AAIVASGVDWAADEQLHDLVVDDD........
G4U9C1_NEUT9/131-240 ...........................................................................ISAEAAEQALASYQVRDHI.LDLELERLRVGQHNATLASELLRLSKTTGTHDVqv.................dgSTKLGRKLGKTKGELRVSRQKWKTIKGATS.ALVAGTGVDWARDERLRDLVLD--pp......
CENPH_BOVIN/133-238 ...........................................................................LNKLIMKSQQETWDLEEKL.LDVRKKRLQLKQASERKLLEIQTEKNKQKDDLD.....................SMENSDKIKAIQQNLETEIQITTVIQHVFQ.NLILGSKVNWAEDPALKETVLQLE........
F6RXE0_XENTR/138-243 ...........................................................................LSSSVMNLQQKEFKILNKIlISICIYYIVLKEQGSAKMLEIQTMKSNWKANRE.....................-EMKNEKIKRLHKVLKEEIDSVTVLQNVFQ.NIILASHVDWAKYPQLKDIVLRLE........
F2PHW1_TRIEC/131-239 ...........................................................................LSLAYENMLTTHTTCLRKL.SNAEVSNIQSIKQNQELVQSLLKLTSREKSADEe..................ipDLELKEELNSLKSENKQKKAQWTRIKRIVS.ASIAASGVDWASDEKLERLVLDDD........
E4UNM1_ARTGP/131-239 ...........................................................................LSLAYENILTTHTTCIREL.SNAEVSNIQSIKQNQELVQSLLKLTRNEKSADEe..................ipDQELKEELNSLISENKQKKAQWTRMKRIVS.ASIAASGVDWASDEKLERLVLDDD........
E9E019_METAQ/124-232 ........................................................................ain----VAKHATEVAFIRNDL.TQVQSDTARVIRRNVGLTSTLFELAEEVKQKQAsr.................ldDEETQSEIRQLEVAMMASRQRWRVIKGVAS.GIVAGSGVDWARDAKLREVVLDLD........
D2H2T8_AILME/1-56 ..........................................................................i-------------------.--------ELKQASESKLLEIQTEKNKQKDDLV.....................DMENSDKIKTIQQNLQMEIQITTVIQHVFQ.------------------------........
F2UDY6_SALS5/143-247 ...........................................................................LCSACLRLSDRYRDLTQEL.EMINADIRDTMLRNRQIYSDIQDLEQQLEAGTQ.....................-EPPSQALDNERQKLENEYVKNAILRNTLQ.LLIVASGVDWAADENLLETMLSL-d.......
G9NA91_HYPVG/112-220 ........................................................................tsi---SVAKQAESTTKLRRDL.TKVQVQSIRICRENVKLTEQLFELAEQAKQKAIr..................lnNPEVQREMDKLTREVKYSRQRWKVMKGVAS.GIIAGSGVDWAGDEDLRNIVLD--pe......
C5G7F8_AJEDR/137-245 ...........................................................................LSLIYTNLSRAHASCTQSL.STAKVDSLHSTAKNQKLVQTLLGLTSAQTSWREg..................itDQKLRSQLETLEKETKAEKANWVTIKRIVS.AAIVASGVDWAADEQLHDLVVDDD........
F2S7D6_TRIT1/131-239 ...........................................................................LSLAYENMLTTHTTCLRKL.SNAEVSNIQSIKQNQELVQSLLKLTSREKSADEe..................ipDLELKEELNSLKSENKQKKAQWTRIKRIVS.ASIAASGVDWASDEKLERLVLDDD........
F7GDG6_ORNAN/1-53 ..........................................................................m-------------------.---------------------------------.....................--EASDLLKRIKENVRKEIQMTVVIQNVFQ.NIIIGTQVNWAEDPALKNIVLQLE........
E6ZMG3_SPORE/160-297 dgdkqyastrkllderddqaleflrvfnetraikqqrvevkarireqrletmkqldtiktikadirtcqlhpsas-------------------.------------------------ARQDSDASQ.....................DLATVQKVQQVQREINEARSKKELVKGILR.GLILESGRDWTKNASTRALMLSL-d.......
C1C3S7_LITCT/86-189 .......................................................................vasl----TLKEQKESRSLEKQL.IDIREKRMALKEKSTALMTEVLSIVDELRFQKE.....................--PKEEKLKKIFKHVKRETDTTFMLQNIFQ.RLIHASRVNWVEDPKLREAVIK--ag......
G1QVE6_NOMLE/136-241 ...........................................................................LNKLIMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................GMENSERIKIIRQNLQMEIKITTVIQHVFQ.NLILGSKVNWAEDPALKEIVLQLE........
D8M956_BLAHO/140-245 .........................................................................lr--KEYERKLQENASLLEEN.QSLKAACDTLRGQIHEQETVLQEMEEKESKSVN.....................REKQQHELKIAISKYEVQRRQNEILRNIYS.SLVLASRIDWARKDRIREMML---cve.....
H0Y9E6_HUMAN/76-181 ...........................................................................LNKLIMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................SMENSERIKIIRQNLQMEIKITTVIQHVFQ.NLILGSKVNWAEDPALKEIVLQLE........
H0ZVC1_TAEGU/72-176 ...........................................................................LSQTIIDYQKKIHEKEQQL.INIRRERLSLKVYGGQKLQQIQTMMKRQKEKQA.....................-SMDVRKIEKMLANLEKEREMTTIIQNVFQ.NIIVGSKVNWAEDPSLKAIVLQL-g.......
E9C9D8_CAPO3/157-269 ...........................................................................LSTEALAWSQSVAAKHALL.HKLEQEAKVLRTANRELSATVRAHRQELDAMSApaa..............lgpaRHSAANKLHEARINFGLQRSRSRMVRNVFQ.ALVLESGVNWMDDPAFASLVLSLE........
H1V387_COLHI/121-230 ........................................................................asi---ALSKTSSDIRSAVDEL.TDVEAESLRVGRRNIELAAEVLRLAKETEMRRTge.................tdDPAVQAEMARLQVELKSSRQRWKVMKGTAS.AVVVGSGVDWARDEALTDIVLD--pe......
B6H4J5_PENCW/129-237 ...........................................................................LALAHENLASAHDLVLRQL.SNLEVKNLQINRENQELVRQLLELTKEDSSWREk..................leDHELLSQLDSLETDLKARKAQWETMKSIAS.AVVVASGLNWADDDMLRALVLDE-s.......
F7GYV6_MACMU/136-241 ...........................................................................LNKLIMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................SMENSDRIKIIRQNLQMEIKITTIIQHVFQ.NLILGSKVNWAEDPALKEIVLQLE........
G3W0S9_SARHA/97-202 ........................................................................vng---SILKAQQLTRDLEEKM.LEVKKKRLMFKKAGEEKVLEIKAEKKRKKDESS.....................LLNNSPLIIKMKKNLQKEIDTTVIIQNVFQ.HIVMAAKIDWAADPDLKALILQ--fe......
G9P907_HYPAI/116-225 ........................................................................tsi---SVAQHADSVAKLRDDL.TAVQVQSIRVCRQNMDLTSELFALAEQAKQKKAvr.................vdDPRVQQEIEKLTREVKTSRQRWRVMKGVAS.GVVAGSGVDWAKDEDLRNIVLD--pe......
G1L8V0_AILME/135-241 ...........................................................................LNKLIMKSHQESWDLEEKL.LDVRKKRLQLKQASESKLLEIQTEKNKQKDDLV.....................DMENSDKIKTIQQNLQMEIQITTVIQHVFQqNLILGSKANWAEDSAFKETVLQLE........
H0W563_CAVPO/104-199 ........................................................................ttk---EVLKLNKLHWKL-EEL.LDLRKKRLQLKLASESKLLETQTDFSKKEIQTE.....................KKQRSLTIKTMQQSLQMEMEITTVIR----.-----SEVNWAVDPALKESVLQL-k.......
C5P9N1_COCP7/133-240 ...........................................................................LSLVYENLAGVNNSCVENL.SNAEVSNIRAVKDNRDLVRSLLELTDGNAEEEEi...................kDLKSKEELETLKRENKNRRDEYMTMKRIVS.AVIVASGLDWASDEKLLTLVVEDE........
C4JZ24_UNCRE/132-239 ...........................................................................LSLAYENLASINSSCSERL.SNAEVDNIQTATENRDLVQSLLELTRGKDEKLQi...................eDPDLRSELETLERKTKKAKADYVTMKRIIS.ASIVASGIDWASDETLLKLVVDDE........
Q0CNP0_ASPTN/129-237 ...........................................................................LSLAHENLNAAQNSTLRKL.SDVEVENLQLHRKNKDLVQELLSLTKNDESWREk..................leDADLRAQLDQVRTDYKKSKAKWDTMKSVAS.AIVVGSGVNWAEDEDLLSLVLDE-s.......
E2R8X4_CANFA/139-244 ...........................................................................LNKLIMKSHQESWDLEEKL.LDVRKKRLELKQSSENKLLEIQTEKNKQKDDLA.....................NMENSNKIKAMQRNLKMEIQITTVIQNVFQqNLILGSK-AWAEDPTLKEIVLRLE........
C6HRL4_AJECH/137-245 ...........................................................................LSLIYVNLSRAHGSCTQSL.SNTKVDGMHGTAKTQELVQTLLGLTSAEKSRREa..................itDPALISQLEAQEKETKAERASWVTMKRVVS.ALIVASGIDWAADEALHDLVVDDE........
G2YBK7_BOTF4/126-235 ..........................................................................m-SETLAQISNQIQSSREEL.MRESNENIVTGRKNIELATEMLALAEEANSQGKen.................iqDPDVRAQLDELEGAMKNSRQRWRIMKNTAS.AVIVGSGIDWARDPKLLAIVLDDD........
H0WK59_OTOGA/135-240 ...........................................................................LNKLIMKSQQESWDLEEKL.VDVRKKRLELKQASESKLLEIQMEKNKQKNELD.....................SMENSDKVKTIQQNLQMEIQITTVVQHVFQ.NIILGSKVNWAENSALKETVLQLE........
B9EMR0_SALSA/129-233 ...........................................................................LCLKIKTLQQESCELQDQI.TDLKKQRLDLKRLTHEKMKEMDELKRKREHPEA.....................-EKYRNVLQKGQSHLEKYQKMATITQNVLR.GIIIASKVNWRDDPKLRDIAMTL-e.......
G2R207_THITE/121-227 .............................................................kvaslcadldsawg-----------------RL.AELETESLRATQRNMELASEVLRLAAGTNDKTPsq.................leGGRLEMELAGHEAEMKSNRRRWRIMKGAAS.AIVAGSGIDWVRDERLRDLVLDL-p.......
H2QR06_PANTR/136-241 ...........................................................................LNKLIMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTKKNKQKIDLD.....................SMENSERIKIIRQNLQMEIKITTVIQHVFQ.NLILGSKVNWAEDPALKEIVLQLE........
C1G1C0_PARBD/76-184 ...........................................................................LSLIYENLSRAHASCIQTL.SDAKVENIQHNEKNQQMVQTLLGLTSAEKTWREe..................itDPKLRAQLETVEKECKAEQANWVTIKRIVS.AAIVASGIDWAEDEKLRDLVVDD-v.......
A2QDK2_ASPNC/74-182 ...........................................................................LSLAHENLNTAHNATLRRL.SSLEVENSQIHQQNQELVRELLALTVDDESWREn..................leDAELKAQLDQLDADRRKSKAKWETMKNIAS.GMVVGSGVNWAEDERLTALVLDE-s.......
F2SW09_TRIRC/131-239 ...........................................................................LSLAYENMLTTYTTCIRKL.SSTEVSNIQNIKQNQELVQSLLKLTNSEKSADEe..................ipDLELKEELNSLKSENKQKKAQWTRIKRIVS.ASVAASGVDWASDEKLERLVLDDD........
Q0UIN8_PHANO/130-239 .....................................................................vsmvhg------SLTSKLVSTQRTI.NTAAQANIVASRKNRELAAEMLALAEDMKAQSAkd.................ieDPRLRDQVSAVEKELRESRRRAKTLKGVLS.AMVVGSGINWAADEGLTELVMDDE........
H2PFR2_PONAB/136-241 ...........................................................................LNKLIMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................SMENSERIKIIRQNLQMEIKITTVIQHVFQ.NLILGSKVNWAEDPALKEIVLQLE........
G5B8V0_HETGA/131-236 ....................................................................lklnksv-------MKQESWELEEKL.LDVRKKRFQLKQASESKLLEIETEKKKRKEELG.....................SMENSDKIKTMKQSLQRERQIATVIQHVFQ.NLILGSKVNWAADPALKETVLELE........
F1M389_RAT/131-236 ...........................................................................LQKLIMKSQEESKELEKKL.LDVRKKRLQLKQASRSKLLEIQTERNKQKEDVD.....................KMENSEVVKAMKDKLQLEIKITTVIQHAFQ.GLILGSKTNWAEDPTLRELVLQLE........
G1PLH1_MYOLU/94-199 ...........................................................................LNKIIMKLQQESWDLEEKL.LDVKKKRFELKRASESKFLEIQTEKNKEKDALA.....................SMENSDKIKTLQQKLQKEIQITTVIQHVFQ.NLILGSKVNWAEDSAFKETVLQLE........
F7HY65_CALJA/136-242 ...........................................................................LNKLVMKSQQESWDLEEKL.LDIRKKRLQLKQASESKLLEIQTEKNKQKIDLD.....................GMENSERIKIIRQNLQMEIKITTVIQHVFQqNLILGSKVNWAEDPALKETVLQLE........
I1RA59_GIBZE/121-230 .........................................................................as--VSVARQASQTNEVWKAL.TTAQSDTLRKSRENVTLAAELFELADQAKLKKRvp.................pnNSKMMEEQKRLEAEVKASKQKWRVMKGVAG.GIIVGSGVDWVQDDELRDVVLD--pe......
C9SMQ0_VERA1/27-143 .........................................................................as--ATLARNATNLRDTLDAL.AATRAGALAAGRRNAELAQEVLRLAEEAARRRDggsep..........qggggeDDEARREMQLLRAGLKASRQKWKVMKGTAS.AIVVGSGVDWVGDEGLRWMVLD--pe......
A6QRL1_AJECN/109-208 ..................................................................dpsiqsvhs------------------I.TDSPAESMQGTAKTQESVQTLLGLTSVEKSRREa..................itDPALISQLEAQEKETKAERASWVTMKRVVS.ALIVASGIDWAADEGLHDLVVDDE........
G1KSK7_ANOCA/91-196 ...........................................................................LSTAILQSEQQSRELEEKL.NEVKRSRIALKRAGECKLAQIRDIKRKRKAELE.....................NMKVGEILEKVHGDLQKKIKITTIVQNVFQ.NIIFASKVNWEEDSDLKAIVLQLE........
A1CKR0_ASPCL/129-237 ...........................................................................LSLAYENLTTADNATLREL.SNVEVQNLQLNQRNQELVGQLLDMTKDDMSWREd..................lqDEDLRAQLEELESERRKSRARWETMKSIAS.AIVVGSGVNWAEDDSLTALVLDE-h.......
C3YVL8_BRAFL/24-107 .........................................................satstisnksvysettpt-------------------.------------------------PSQDKQGVEe..................egDVTELVELKGFESHLEQAMSKISSLQHIFQ.ALMIGSQVHWAEDPDMEQLMISL-g.......
E5A8D5_LEPMJ/50-159 .....................................................................vsmvhg------AQTTKLASVTRAL.STAEQANMIANRKNRELAQRMLALAEDMKAQSVkd.................ieDPQLRAQVDAVEKALKESRRRKKTVKGILS.AMIVGSGIHWAADAELTELVMDDD........
Q2UKQ1_ASPOR/157-265 ...........................................................................LSLAHENLNTALSSTLKKL.SNAEVENLQLHQKNKALVRELLDLTKNDESWREe..................ldDMSIKELLEQVKADHKRSKAKWETMKSITS.AIVVGSGVNWAEDEELVALVLDD-s.......
#=GC seq_cons ...........................................................................ls..h.p.tptptsh.ccL.tslchcplplpppspphhtclhplppcpcpppc.....................s.chppplcplcpphctp+pphpsl+plhp.ullluSGVsWAcDtpL+clVLc..........
//
