GenomeNet

Database: Pfam
Entry: CK2S
LinkDB: CK2S
Original site: CK2S 
#=GF ID   CK2S
#=GF AC   PF15011.1
#=GF DE   Casein Kinase 2 substrate
#=GF AU   Coggill P, Hetherington K
#=GF SE   Jackhmmer:Q9NX04
#=GF GA   27.00 27.00;
#=GF TC   27.10 27.50;
#=GF NC   25.50 25.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   22548824
#=GF RT   Identification and characterization of a novel gene, c1orf109,
#=GF RT   encoding a CK2 substrate that is involved in cancer cell
#=GF RT   proliferation.
#=GF RA   Liu SS, Zheng HX, Jiang HD, He J, Yu Y, Qu YP, Yue L, Zhang Y,
#=GF RA   Li Y;
#=GF RL   J Biomed Sci. 2012;19:49.
#=GF CC   It is suggested that CK2S (C10orf109) is important in the
#=GF CC   regulation of cancer cell proliferation. Studies have indicated
#=GF CC   that CK2S is the downstream target of a protein kinase, casein
#=GF CC   kinase 2 (CK2), which is upregulated in cancer cells. CK2S has
#=GF CC   been found to be upregulated in cancer cells. The precise
#=GF CC   mechanism of CK2 targetting CK2S is not well characterised. It
#=GF CC   is found to be localised in the nucleus and cytoplasm [1]. This
#=GF CC   family of proteins is found in eukaryotes. Proteins in this
#=GF CC   family are typically between 160 and 221 amino acids in length.
#=GF CC   There is a single completely conserved residue P that may be
#=GF CC   functionally important.
#=GF SQ   90
#=GS F2DV89_HORVD/6-169    AC F2DV89.1
#=GS F6QY98_HORSE/12-178   AC F6QY98.1
#=GS G1PK43_MYOLU/16-182   AC G1PK43.1
#=GS F2U670_SALS5/63-196   AC F2U670.1
#=GS H2PYP5_PANTR/12-178   AC H2PYP5.1
#=GS Q7XC07_ORYSJ/6-169    AC Q7XC07.1
#=GS I1I6A6_BRADI/6-169    AC I1I6A6.1
#=GS I1I6A7_BRADI/6-169    AC I1I6A7.1
#=GS C3Z1B0_BRAFL/9-174    AC C3Z1B0.1
#=GS CA109_HUMAN/12-178    AC Q9NX04.1
#=GS I1KYR0_SOYBN/6-170    AC I1KYR0.1
#=GS CA109_DANRE/11-176    AC Q8JHH5.3
#=GS H0YTG6_TAEGU/1-95     AC H0YTG6.1
#=GS E9C2N1_CAPO3/111-232  AC E9C2N1.1
#=GS F7AP43_ORNAN/1-141    AC F7AP43.1
#=GS B9H5J6_POPTR/6-172    AC B9H5J6.1
#=GS H0UVR1_CAVPO/12-178   AC H0UVR1.1
#=GS B8BIB3_ORYSI/6-169    AC B8BIB3.1
#=GS C1BZU8_ESOLU/11-176   AC C1BZU8.1
#=GS E9GHQ1_DAPPU/6-170    AC E9GHQ1.1
#=GS C1MUJ7_MICPC/7-171    AC C1MUJ7.1
#=GS G9L4C3_MUSPF/12-185   AC G9L4C3.1
#=GS Q4SVE4_TETNG/101-144  AC Q4SVE4.1
#=GS E1ZHM7_CHLVA/1-76     AC E1ZHM7.1
#=GS C5X2J8_SORBI/6-169    AC C5X2J8.1
#=GS E9IDL0_SOLIN/9-174    AC E9IDL0.1
#=GS H9ZAJ6_MACMU/12-178   AC H9ZAJ6.1
#=GS D6WF79_TRICA/9-171    AC D6WF79.1
#=GS F7CI18_CALJA/12-88    AC F7CI18.1
#=GS B3RV85_TRIAD/26-183   AC B3RV85.1
#=GS E3TF89_ICTPU/11-176   AC E3TF89.1
#=GS E2R7G1_CANFA/12-178   AC E2R7G1.1
#=GS G1U8S4_RABIT/12-179   AC G1U8S4.1
#=GS G3NDW7_GASAC/33-193   AC G3NDW7.1
#=GS G3QXK0_GORGO/12-178   AC G3QXK0.1
#=GS H9F5E6_MACMU/10-176   AC H9F5E6.1
#=GS B9R8Q5_RICCO/1-156    AC B9R8Q5.1
#=GS G7MFX5_MACMU/12-178   AC G7MFX5.1
#=GS G5C6H3_HETGA/12-187   AC G5C6H3.1
#=GS B7PGK8_IXOSC/1-73     AC B7PGK8.1
#=GS F7E4K1_MONDO/12-177   AC F7E4K1.1
#=GS B9ENA2_SALSA/11-176   AC B9ENA2.1
#=GS F7H9Y6_CALJA/12-178   AC F7H9Y6.1
#=GS H0YTG7_TAEGU/2-91     AC H0YTG7.1
#=GS G7JN62_MEDTR/6-168    AC G7JN62.1
#=GS H0WYY0_OTOGA/12-178   AC H0WYY0.1
#=GS A8IYS4_CHLRE/15-144   AC A8IYS4.1
#=GS CA109_MOUSE/12-178    AC Q499E6.1
#=GS F6Z3K1_XENTR/13-177   AC F6Z3K1.1
#=GS H2T4S8_TAKRU/29-194   AC H2T4S8.1
#=GS D8TIW4_VOLCA/2-150    AC D8TIW4.1
#=GS F1NNY8_CHICK/12-177   AC F1NNY8.1
#=GS F4WDU5_ACREC/10-132   AC F4WDU5.1
#=GS B5G1Z8_TAEGU/10-176   AC B5G1Z8.1
#=GS B7Z9X8_HUMAN/75-241   AC B7Z9X8.1
#=GS CA109_XENTR/12-176    AC Q28I03.1
#=GS G7NUA5_MACFA/12-178   AC G7NUA5.1
#=GS A7RHE6_NEMVE/32-199   AC A7RHE6.1
#=GS G3HE14_CRIGR/12-152   AC G3HE14.1
#=GS G1RLM8_NOMLE/74-215   AC G1RLM8.1
#=GS F7CYF0_MACMU/12-178   AC F7CYF0.1
#=GS D2HNA7_AILME/12-178   AC D2HNA7.1
#=GS D7MNK9_ARALL/505-651  AC D7MNK9.1
#=GS B4DRQ5_HUMAN/74-240   AC B4DRQ5.1
#=GS B8LRF9_PICSI/50-214   AC B8LRF9.1
#=GS H2N7Y0_PONAB/12-178   AC H2N7Y0.1
#=GS E5S2G4_TRISP/726-889  AC E5S2G4.1
#=GS G3T9P8_LOXAF/12-178   AC G3T9P8.1
#=GS H2M1W3_ORYLA/14-181   AC H2M1W3.1
#=GS H3AS34_LATCH/13-178   AC H3AS34.1
#=GS D7UDC1_VITVI/6-170    AC D7UDC1.1
#=GS E2AIM6_CAMFO/7-150    AC E2AIM6.1
#=GS G3WJ24_SARHA/14-179   AC G3WJ24.1
#=GS I1KYR1_SOYBN/6-166    AC I1KYR1.1
#=GS F7DU41_CALJA/12-178   AC F7DU41.1
#=GS E1BYL6_CHICK/9-174    AC E1BYL6.1
#=GS I1QW27_ORYGL/6-169    AC I1QW27.1
#=GS G3MPP7_9ACAR/16-182   AC G3MPP7.1
#=GS G1L2L4_AILME/17-183   AC G1L2L4.1
#=GS C1FHE8_MICSR/7-171    AC C1FHE8.1
#=GS A7MB79_BOVIN/12-178   AC A7MB79.1
#=GS H9GP34_ANOCA/12-179   AC H9GP34.1
#=GS D4AB92_RAT/12-178     AC D4AB92.1
#=GS C5WRF1_SORBI/6-169    AC C5WRF1.1
#=GS F1R3X4_DANRE/11-176   AC F1R3X4.1
#=GS A4RYY9_OSTLU/6-175    AC A4RYY9.1
#=GS B6SQG5_MAIZE/6-169    AC B6SQG5.1
#=GS A5C6J5_VITVI/144-246  AC A5C6J5.1
#=GS E1ZHM8_CHLVA/8-92     AC E1ZHM8.1
#=GS Y5382_ARATH/6-167     AC Q6NPG7.1
F2DV89_HORVD/6-169               ..............RKVQQRVRKAREETERWDDLNSRLLSQFSNATTIITRLPVLGDAK....NYGV-.LRCV....P.NIREDLLGKQME.......SLELIFVLM.RETLEELNGIAKGLSKVLRDTNQMVR---GGSALTAK.QLQLKVGILPTITDCLDGLRTLSDMHQA.E.........Y..ALKSSIISLL.TWK..SSSSDIAAMRQL....................
F6QY98_HORSE/12-178              ..............EALRQCFPVVEEQQGLWQSTLRDCQPLLASLGNLAEQLQAAQSLR....FEDVPaLRAF....P.DLKERLRRKQLA.......AGDTVLDKL.GERLAALLKVRDTVSSHVERVLQIYEQHA--DTISID.AVLQASAVSPSVADMLEWLQDIERHYRN.S.........Y..LKRKYLLSSI.QWE..DLVNIQALPKAW....................
G1PK43_MYOLU/16-182              .............a-ALKKCFPVVEEQQRLWRSSLSDCPPLLASLGNLAEQLQAAQNLR....FEDVPaLRAF....P.GLQERLRRKQLE.......AGDAVLDQL.GERLAALLNVRDTVSSHVGQVLQIYEQHA--DAIGID.AVLQASAASPSVADMLEWLQDIERHYQR.R.........Y..LKRKYLLSSI.DWG..DLAGIQALPTAW....................
F2U670_SALS5/63-196              eeqeeqaavpedal---------------------------------------------....---TC.LRKF....P.NLEQRLRLCHAR.......SAEAQHARI.TTAWDKVVEALNDMVRVEADIQASFTQLC--KEHSVS.EMEERGTAHASVAEFVMGAQDVTAYTRT.V.........V..HTNQQLLDNI.RASqrSVASIEKATDEW....................
H2PYP5_PANTR/12-178              ..............EALKKCFPVVEEQQGLWQSALRDCQPLLSSLSNLAEQLQAAQNLR....FEDVPaLRAF....P.DLKERLRRKQLA.......AGDIALDKL.GERLAILLKVRDMVSSHVERVFQIYEQHA--DTVGID.AVLQPSAVSPSVADMLEWLQDIERHYRK.S.........Y..LKRKYLLSSI.QWG..DLANIQALPKAW....................
Q7XC07_ORYSJ/6-169               .............r-RVQQRVRKAREEMDRWDDLNSRLLSQFANAAAIVARLPVLEEVK....NYGV-.LRCV....P.NIRENLLGKQME.......SLEIIFVSM.RETVEEFNSIARSLHKALRDTNQMVR---GGSALSAK.QMQLQVGILPTIADCLDGLRTLCEMHQA.E.........Y..ALKSSVISSL.TWT..SSSSDIAAMRQL....................
I1I6A6_BRADI/6-169               ..............RKVQQRVRKAREETERWDDLNSRFLSQFSNAAAIIARLPVLGDAK....NYGV-.LGCV....P.NVREDLLGKQME.......SLELIFVSM.RETLEEFSGIAKGLNKALRNTNQMVR---GGSTLTAK.QLQLQVGILPTIAYCLDGLQTLSDMHQA.E.........Y..ALKSSVISLL.TWK..SSSSDIAALRQL....................
I1I6A7_BRADI/6-169               ..............RKVQQRVRKAREETERWDDLNSRFLSQFSNAAAIIARLPVLGDAK....NYGV-.LGCV....P.NVREDLLGKQME.......SLELIFVSM.RETLEEFSGIAKGLNKALRNTNQMVR---GGSTLTAK.QLQLQVGILPTIAYCLDGLQTLSDMHQA.E.........Y..ALKSSVISLL.TWK..SSSSDIAALRQL....................
C3Z1B0_BRAFL/9-174               ..............RQLKSAYVTVEKQTVRWKEIHQNSEQYVNSLCNLSEQLDSCERVP....EETAF.LKDF....H.DLKSRLRAKLLG.......EMEKMVGKL.RETLCSLQEVSNSISRQYAASMHTYQTHA--VELGIH.KVVQRSATEPSVADMLEWLGDIDRAVRE.L.........Y..LQKQFLLDTL.NYD..DTRQMQSLHRRW....................
CA109_HUMAN/12-178               ..............EALKKCFPVVEEQQGLWQSALRDCQPLLSSLSNLAEQLQAAQNLR....FEDVPaLRAF....P.DLKERLRRKQLV.......AGDIVLDKL.GERLAILLKVRDMVSSHVERVFQIYEQHA--DTVGID.AVLQPSAVSPSVADMLEWLQDIERHYRK.S.........Y..LKRKYLLSSI.QWG..DLANIQALPKAW....................
I1KYR0_SOYBN/6-170               ..............KKFQSKFRKVREEMSRWDELQSCLISQFRNASHIVDRLQVLQNSN....NYGV-.LNCA....S.GLKDALLVKQIE.......SLRNILVSM.RKTLEEFHCIVLSLDKIHRDSRQQVKG--GSCHLNMK.QLQQQIGIKPSLIYCLDSLMFIHEIYNS.E.........Y..LLKSSVISAL.SEI..ALKPSDSDL---gal.................
CA109_DANRE/11-176               ..............QELRRGFEALKAAKDTFDGGHAECQELVSSLGNLAPQLKALKQVQ....ISETP.LSGF....P.CLQQRLHYKLSL.......AVDALLAKL.AEKMAALQKVWDAFAQQVFTVVQLYEKNT--DALDIS.VCVSRSAVCPSVSDMLEWLQDADRYYRL.Q.........L..MQSRLLLQTL.TPT..DLTSMETAPNRW....................
H0YTG6_TAEGU/1-95                .............v---------------------------------------------....-----.----....-.------------.......------EQL.GERREELRAVRDAVGAAGSAVLRLLEERG-PAEPRLA.AVLRRGPRCPSLADVLEGLQDVERFYRH.L.........Y..LEIKLLLQRL.SLD..SLADVEALPQSW....................
E9C2N1_CAPO3/111-232             .......eqsssnm---------------------------------------------....RGGAP.LQHF....D.KLNPRLAEKLIV.......YTDTLLRAL.RGSLSTLWEVVEHLERLQHSAERSIA--A--LPLPAA.IASSPSEIPPSV--QVEWIRAIAHMYST.E.........F..QRKTAVVESL.KLD..ASRNSSEA----vi..................
F7AP43_ORNAN/1-141               ............xv---------------------------VDSLGNLAEQVEAAQNVA....FEAAP.LGAF....P.DLRERLKRKQLT.......AGDTILDKL.EERMAVLLGVRDAVSGHVERAFEVYEQHA--RPADID.AILLRSAVIPSIADMLEWLQDIERSYRN.L.........Y..LGKRDLINQI.SWD..NLPFLQALPQAW....................
B9H5J6_POPTR/6-172               ..............KKYQQRFRKVRGLMEEWEQLQSRLISQFSNASAIIERLKVIGDCN....NYGN-.LKSV....D.GIVDAVVRKQLE.......SLQTILLSM.NKTLEEFRGVVLTIEKMYRDGRQLVKGGGGSNQLNVK.QLRQRIGIKPCLADCLDGLMILHEMHQA.E.........Y..LLKSSVVSAL.SAL..TLKPSSSDLGA-l...................
H0UVR1_CAVPO/12-178              ..............EALKKCFPVVEEQQVLWQSALQDCQPLLTSLSNLAEQLQAAQNLR....FEDVPaLGDF....P.DLQERLRRKQLE.......AGDTVLDKL.EEKLDTLLKVRDTVSSHVERVFQTYEQHA--DAIGVD.AVLQPSVVSPSVADMLEWLQDIERHYRS.S.........Y..LKRRYLLSSI.QWG..DLAGIQALPTAW....................
B8BIB3_ORYSI/6-169               .............r-RVQQRVRKAREEMDRWDDLNSRLLSQFANAAAIVARLPVLEEVK....NYGV-.LRCV....P.NIRENLLGKQME.......SLEIIFVSM.RETVEEFNSIARSLHKALRDTNQMVR---GGSALSAK.QMQLQVGILPTIADCLDGLRTLCEMHQA.E.........Y..ALKSSVISSL.TWT..SSSSDIAAMRQL....................
C1BZU8_ESOLU/11-176              ..............QVLKKCFQNLENNQKVWNSALGECTSLVGSLGNLVDQLRALEKVK....IVNTP.LHTF....P.DLQERLNFKLLQ.......ALDIVLVKL.ADKLCSLQQVRDAVSNQVSGAFQLYEHNI--DTLDLA.TCTQRSAIAPSIADMLEWLKDAERYYRQ.Q.........F..LRRKNVLQAL.RPE..DLYLLEAVPKRW....................
E9GHQ1_DAPPU/6-170               ............ts--LLKTYSSIEIHRLKWNEILQGFESSLKVMSGLSDQLECVLKTE....LCE-L.SRKF....P.DLNGRLEQIIRA.......LMEEEMTTM.VLLLEELYQENQRIKNICEVTYKLYVEDF--DTIQADpTFYEGTSLYPPVSLMIEWMDEINMCYAN.R.........L..INAKHLLEVF.NYS..S-Q---------svtnlqnml...........
C1MUJ7_MICPC/7-171               .............g-KYRSLYAKARVVLERWSAAQTRATNLVDSVASIYERLAHLSETS....RYGPL.ADSF....P.DLPARTRDAQYA.......ALDRVLAAL.EDELELFDDLANLLDKIQRDGSALVR---ALRPPPPF.AGALRRAHQPSLAECALGLEDVWRAYHD.E.........A..TLKRVVCDEL.VVD..ASVEDVKTMAK-l...................
G9L4C3_MUSPF/12-185              ..............EALRKCFPVVEEQQGLWQSTLGDCQPLLASLSNLAEQLQAAQNLR....FEDVPpLRAF....P.DLKERLRRKQLAaggtvrgAGDTVLDKL.GERLATLLKVRDTVSRHVEQVFEIYEQHA--DSIGID.AVLQASVLSPSVADMLEWLQDIERHYRH.S.........Y..LKRKYLLSSV.QWG..DLANIQALPEAW....................
Q4SVE4_TETNG/101-144             ..........lrha---------------------------------------------....-----.----....-.------------.......---------.-------------------------------------.---------------VTGCKDAERHYQR.Q.........F..VRRKALLQTL.RAD..DLSLLESFPKSW....................
E1ZHM7_CHLVA/1-76                .............m---------------------------------------------....-----.----....-.------------.......---------.--------------ARQAQQAQRMIR---QDRSLTPA.VCAVAAGPIPSIAQCLQGLEDISRMHAE.E.........L..RLKDALVLEV.RYD..TSEPDMQQVAA-l...................
C5X2J8_SORBI/6-169               ..............RKVQQRVRKAREEMDQWDDLNTRLLSQFSNAAAVISRLQALGEDK....NYG-P.LHGV....P.NIREDLIGNQME.......VLEFIFVKI.RDTLEKFNGVVKALNKALRDTKQMVR---GGSALTAK.QMQLQVGILPSIADCLDGFQTLCEMHHA.E.........F..TLKSSVFSLL.TWK..SSSSDIAVLRQL....................
E9IDL0_SOLIN/9-174               ...........lir-----YFARLERLDDKWKELSQKAERPLEVLANRAEQLRHVTNSE....EIDGV.EDSV....DqETRERLIFKILM.......GFEEEIALL.SNILTQLNDANQDLKNYLINLENARS-KVSLKDETMQ.ELIKGTPYRPTLELLLEWAVEGFQFFHN.M.........Y..LRISDCMRLI.DYK..EEETINNLT---ssf.................
H9ZAJ6_MACMU/12-178              ..............EALKKCFLVVEEQQGLWQSALQDCQPLLSSLSNLAEQLQAAQNLR....FEDVPaLQAF....P.DLKERLRRKQLA.......AGDIVLDKL.GERLAILLKVRDVVSSHVERVFQIYEQHA--DTVGID.AVLQPSAVSPSVADMLEWLQDIERHYRK.S.........Y..LNRKYLLSSI.QWG..DLANIQALPKAW....................
D6WF79_TRICA/9-171               ..............KYLVTFCKALPAHVDCWRSALQDSVKPLQNLANLCEQQRAIQNVK....LCN--.FGDY....S.DAQGVILHRIAI.......GIEEELLCI.KKLVDKVNECNIDLKNKLLVFERSTL---NLNWEENN.ELIRGNGSQPPLAKLLQYSLQFLNYFTK.G.........A..KDISDKLKVL.NVK..NVKSVKQLKNSF....................
F7CI18_CALJA/12-88               ..............EALKKCFPVVEEQQGLWQSALLDCQPLLVSLSNLAEQLQAAQNLR....FEDMPaLRTF....P.DLKERLRQ----.......---------.-------------------------------------.----------------------------.-.........-..----------.---..------------psssrcktqsaam.......
B3RV85_TRIAD/26-183              ...........ymg----SRAKKILDQLVLWEAAHNSSKKCLQSLTNLADQLQATRTCDqkglWQKTQ.LGQF....Q.DLIIRLNYKQVQ.......AMEALMNAL.KTDLMTCNDITNTIARFKASAFSIYQKYA--DEIQLQ.DAVMPTATCPALVDLLDWYLTKKRALHD.-.........-..----------.---..------------inyedidtintmqelw....
E3TF89_ICTPU/11-176              ..............QELRKCFQSLKANQTVWNGVLEECTPLLSSLGNLAEQLRALKSVE....IANTP.LSTF....P.NLPERLQHKLLN.......AVDTVLGEL.SEKVNALDLMRASVCKQVAAVFQMYEQNS--ELLPIS.TCVARCALSPSIADMLEWLQDTERYYRM.Q.........C..IQRKNLLQLL.KPD..DLTLLETAPKRW....................
E2R7G1_CANFA/12-178              ..............EALRGCFPAVQEQQRRWRGALGDCQPLLAALGSLAEQLQAAQVAR....LDDAPpLRAF....P.GLRERLRRKQLE.......AGDDVLDKL.GETLATLLKVRDVVSRHVEQVFEVYEQHA--DAIGID.AVQRASAVSPSVADMLEWLQDIERHYRR.S.........Y..LKRKYLLSSI.QWG..DLANIQALPKAW....................
G1U8S4_RABIT/12-179              ..............EALRRCFPAVEEQQGLWQGALRDCQPLVAALSNLAEQMQASQSVR....FEDVPaLRAF....P.DLQERLRRKQLE.......AGDAVLDKL.GERLATLLKVRDTVSSQVERVFQVYEQHA--DTLGLD.AVLQPSAASPSVADMLEWLQDMDRHYPSgR.........Y..LKRKDLLSSI.QWG..DLASIQALPQAW....................
G3NDW7_GASAC/33-193              ..............QALRKSFQTLEKNQKVWTSVLAECSPLMESLGNLAEQSRALSNVQ....ISNTP.LRDF....P.DLEGRLRFKLSQ.......ATDTVLGKL.NEHMSSLQSVRDSISGQVSAVFQLYELNT--ESLDLP.TLTERSAAAPSVADMLEWLQDAERHYRQ.-.........-..---KTLLLTL.RAD..NLSLLESAPKRW....................
G3QXK0_GORGO/12-178              ..............EALKKCFPVVEEQQGLWQSALRDCQPLLSSLSNLAEQLQAAQNLR....FEDVPaLRAF....P.DLKERLRRKQLA.......AGDIVLDKL.GERLAILLKVRDMVSSHVERVFQIYEQHA--DTVGID.AVLQPSAVSPSVADMLEWLQDIERHYRK.S.........Y..LKRKYLLSSI.QWG..DLANIQALPKAW....................
H9F5E6_MACMU/10-176              ..............EALKKCFLVVEEQQGLWQSALQDCQPLLSSLSNLAEQLQAAQNLR....FEDVPaLQAF....P.DLKERLRRKQLA.......AGDIVLDKL.GERLAILLKVRDMVSSHVERVFQIYEQHA--DTVGID.AVLQPSAVSPSVADMLEWLQDIERHYRK.S.........Y..LNRKYLLSSI.QWG..DLANIQALPKAW....................
B9R8Q5_RICCO/1-156               ..............-------------MEKWDNFQSRLVSQFRNASSIIDRLQMIRESN....NYGS-.LNCV....G.GIADVVMRKQME.......SLQTILISI.NKTLDEFQGIVMILERMHRDGKQLVQ-GGGSNHLTAK.QLQQRVGIKPCLADCLDGLMILRDMHRS.E.........Y..LLKSSLVSAL.PAL..VLKPSSSDLAA-lqql................
G7MFX5_MACMU/12-178              ..............EALKKCFLVVEEQQGLWQSALQDCQPLLSSLSNLAEQLQAAQNLR....FEDVPaLRAF....P.DLKERLRRKQLA.......AGDIVLDKL.GERLAILLKVRDVVSSHVERVFQIYEQHA--DTVGID.AVLQPSAVSPSVADMLEWLQDIERHYRK.S.........Y..LNRKYLLSSI.RWE..DLANIQALPKAW....................
G5C6H3_HETGA/12-187              ..............EALKKCFPVVEEQQGLWQSTLQDCQPLLASLSNLAEQLQAAQNLR....FEDVPaLRAF....P.DLQERLRRKQLE.......TGDTVLDRL.EEKLDTLLKVRDTVSSHVERVFHTYEQHA--DALGID.AVLQPSVVSPSVADMLEWLQDIERHYRS.SyplhpfervY..LKRKYLLSSI.QWG..DLAGIQALPTTW....................
B7PGK8_IXOSC/1-73                ...........mls---------------------------------------------....-----.----....-.------------.......---------.---------------GACQKALHVYEEQR--QGLRVE.DICLRTETEPSIADMVEWVMDAERHFSS.Q.........Y..----------.---..------------pfealnlphvslqvlrhcsl
F7E4K1_MONDO/12-177              ..............EALKKAFHVVEHQHGLWKSTLSDCSPLLASLSNLAEQLQASQNVR....LEETP.LRAF....P.DLKDRLRRKLLA.......AGDAILDQL.GEKLTSLLQVRDTVSSHVEQVFELYEQKA--DELGLD.AVLQPSAVSPSLADMLAWLQDIDRHYRN.A.........Y..LARKQLVAQI.RWG..DVRHVQTLPPAW....................
B9ENA2_SALSA/11-176              ..............QTLKKCFQSLENNQKVWNSVLSECKPLMVSLGNLEEQLRAFQKVQ....IANTP.LHTF....P.DLHQRLHFKLIQ.......AVDIVLGKL.TDKMCSLQSVRDAISNQVSGAFQLYEQNI--GSLDLA.TCTQRSPVAPSIADMLEWLQDAERYYRQ.Q.........F..LRRKNLLLTL.RAD..DLSLLETAPKRW....................
F7H9Y6_CALJA/12-178              ..............EALKKCFPVVEEQQGLWQSALLDCQPLLVSLSNLAEQLQAAQNLR....FEDMPaLRTF....P.DLKERLRRKQLA.......AGDIVLDKL.GERLAILLKVQDTVSSHVERVFQIYEQHA--DTVGID.AVLQSSAVSPSVADMLEWLRDIERHYRR.R.........Y..LKRKYLLSSI.QWG..DLANIQALPKAW....................
H0YTG7_TAEGU/2-91                ............ag---------------------------------------------....-----.----....-.------------.......---------.---REELRAVRDAVGAAGSAVLRLLEERG-PAEPRLA.AVLRRGPRCPSLADVLEGLQDVERFYRH.L.........Y..LEIKLLLQRL.SLD..SLADVEALPQSW....................
G7JN62_MEDTR/6-168               ..............KKFQSKFNKVREEMNQWDELQSRLISQFRNASHIVDRLQVLQKSS....NYGI-.LNCV....G.AVSDVLLQKQID.......SLNTISFSM.RKTLEEFHCIVLSLEKMHRDGRQLVKGSS--SRPTMK.QLQQRVGVKPTLIDCLDGLSFLHEIYYS.E.........Y..LLKTSIVSAL.SSM..ALI---------psnasdl.............
H0WYY0_OTOGA/12-178              ..............EALRKCFPVVEAQEGLWQSTLRDCQPLLTSLSNLAEQLQAAQNLR....FEDVPaLRAF....P.DLKERLRRKQLA.......AGDIVLDKL.AEKLAILLKVRDTVSSHVEQVFQTYEQHA--DVVGID.AVLQPSVVSPSVADMLEWLQDIERHYRR.R.........Y..LKRKSLFSSI.QWG..DLANIQALPKAW....................
A8IYS4_CHLRE/15-144              ......eclerwla-------------------------------------LQVLHDRR....NYAA-.LPDS....Q.QLQTLVLAKQIR.......ALESVFGRL.QENISEMASVTRAQERLVVESWKLLGEHP-----SAA.ACGAVQSGGASVAQLVECMEDVWRCCRD.D.........L..AVRAAALAGM.SHT..TS----------pqqfarl.............
CA109_MOUSE/12-178               ..............EALRKCFPVVEEQQNLWQSTLQDCSPLLSSLSNLAEQLQAAQSLR....FEDVPaLRPF....P.DLQERLRRKQLE.......AGDVVLDKL.AERLATLLKVRNTINSHVEQVFQAYEQHA--AVLDID.TVLRPSVVSPSVADMLEWLQDIDRHYGS.S.........Y..LKRKYLLSSI.HWG..DLASIQALPKAW....................
F6Z3K1_XENTR/13-177              ..............QSLRKSFDAIEPLHEEWNNTLLECNPHLTSLSNLAEQLQACQRVL....FKKTP.LSSF....I.NLQEHLRFKLQA.......AMEFNLEIL.NQKLSTLQRIRDSVSQVVGSVLYMYETSI--EKIGLE.AILERSSLCPSIADMLEWLQDIEKHYRN.Q.........Y..LQRKLLLQVC.GGH..-LSDIQALPQSW....................
H2T4S8_TAKRU/29-194              ..............QALRKSFQRLESSQKVWASVLAECSPLIASVGNLAEQLRALSSLH....LPSTP.LNVF....P.DLEDRLRFKLLH.......AVDTALVRL.NEQMCSLQSVRDSFSNQVSAVFQLYEQNR--DSLDAS.TVMERSAMAPSICDMMGWLQDAEHHYRQ.Q.........F..VRRKALLQTL.RAD..ELSLLESSPKRW....................
D8TIW4_VOLCA/2-150               ...........dfa---------------KFKAAVQRANDCLERWFSL-QRLPALSDVR....NFSA-.LPSA....P.QLQQLVFAKQAR.......ALEAVFGRL.QANLVELESVVRSQERLVVEMWRLLG-----ESPSPG.ACGAVQPGGASVAQMVESVEDVWRMCRD.D.........L..AVRGAALASL.SHT..TTPR--------kfaevqaa............
F1NNY8_CHICK/12-177              ..............EALREWAVAAARRDAAWRAAVAACAPLLASLAGLAAQMRAAQRLA....WDGTP.LGAF....S.ELRERLWRKQRG.......AAEALLEEL.CERREELRAVRDAVGAGAAAVLRLYEERA--AELSLT.EVLRRGPRCPSLADALEGLQDVERYYRH.M.........Y..LEIRLFLLLI.SCD..SLADMEALPQAW....................
F4WDU5_ACREC/10-132              ..kidgaensidqe---------------------------------------------....-----.----....-.-TRERLIFKVLM.......SLEEEMAFL.SNILTQFNDINQDLKNYLVNLENARS-KISLKDKLMQ.ELIKGTSYRPALELLLQWATEGYQFFHN.M.........Y..LRISDCMKSI.DYK..TEETVSNLI---ssf.................
B5G1Z8_TAEGU/10-176              .............a-ALRAWAEAVARAAEAARAAVAAAAPALGSLAALAAQVRALRRLP....RGAAP.LGAF....P.DLRARLWLKQRG.......AAEALLEQL.GERREELRAVRDAVGAAGSAVLRLLEQRG-PAEPRLA.AVLRRGPRCPSLADVLEGLQDVERYYRH.L.........Y..LEIKLLLQRL.SLD..SLADVEALPQSW....................
B7Z9X8_HUMAN/75-241              ..............EALKKCFPVVEEQQGLWQSALRDCQPLLSSLSNLAEQLQAAQNLR....FEDVPaLRAF....P.DLKERLRRKQLV.......AGDIVLDKL.GERLAILLKVRDMVSSHVERVFQIYEQHA--DTVGID.AVLQPSAVSPSVADMLEWLQDIERHYRK.S.........Y..LKRKYLLSSI.QWG..DLANIQALPKAW....................
CA109_XENTR/12-176               ..............QSLRKSFDAIEPLHEEWNNTLLECNPHLTSLSNLAEQLQACQRVL....FKKTP.LSSF....I.NLQEHLRFKLQA.......AMEFNLEIL.NQKLSTLQRIRDSVSQVVGSVLYMYETSI--EKIGLE.AILERSSLCPSIADMLEWLQDIEKHYRN.Q.........Y..LQRKLLLQVC.GGH..-LSDIQALPQSW....................
G7NUA5_MACFA/12-178              ..............EALKKCFLVVEEQQGLWQSALQDCQPLLSSLSNLAEQLQAAQNLR....FEDVPaLRAF....P.DLKERLRRKQLA.......AGDIVLDKL.GERLAILLKVRDVVSSHVERVFQIYEQHA--DTVGID.AVLQPSAVSPSVADMLEWLQDIERHYRK.S.........Y..LNRKYLLSSI.RWG..DLANIQALPKAW....................
A7RHE6_NEMVE/32-199              ..............RKLRKVFTSVEKQIVKADDALTHSNGLISSLLNLLEQLAACEKVS....FDTEP.LAHF....G.DLQGRLRFKLTS.......AIEPVLVKI.HEDLNTIKEVASRFAEFRRSSFDVYNQHASKGNLSVA.EAITAGPVCPSIASMLEWLQQLERMYAG.L.........C..EEKTEILEGI.TYN..DLPQSQKELRRW....................
G3HE14_CRIGR/12-152              .............e-VLRKCFPVVQEQQDLWQSTLQGCSSLLSSLSNLAEQLQASQNLR....FEDVPaLRPF....P.DLQERLRRKQLE.......AGDIVLDKL.AERLATLLKVRDTISSHVERVFQTYEQHS--AALDMD.AVLQPSVVSPSVADMLEWLQDIDRHYRS.-.........-..----------.---..------------s...................
G1RLM8_NOMLE/74-215              ..............EALKKCFPVVEEQQGLWQSALRDCQPLLSSLSNLAEQLQAAQNLR....FEDVPaLRAF....P.DLKERLRRKQLA.......AGDIILDKL.GERLAILLKVRDMVSSHVERVFQIYEQHA--DTVGID.AVLQPSAVSPSVADMLEWLQDIERHYRK.S.........Y..----------.---..------------....................
F7CYF0_MACMU/12-178              ..............EALKKCFLVVEEQQGLWQSALQDCQPLLSSLSNLAEQLQAAQNLR....FEDVPaLRAF....P.DLKERLRRKQLA.......AGDIVLDKL.GERLAILLKVRDVVSSHVERVFQIYEQHA--DTVGID.AVLQPSAVSPSVADMLEWLQDIERHYRK.S.........Y..LNRKYLLSSI.RWG..DLANIQALPKAW....................
D2HNA7_AILME/12-178              ..............EALRKCFPVVEEQQGLWQSSLRDCQLLLASLSNLAEQLQAAQNLR....FEDVPpLRAF....P.DLKERLRRKQLA.......AGDTVLDKL.GERLAALLKVRDTVSRHVEQVLEIYGQHA--GSIGVG.AVLQASAASPSVADMLEWLQDVERHYRD.S.........Y..LKRKYLLSSI.QWG..DLANIQALPKAW....................
D7MNK9_ARALL/505-651             ..............RKWQQKFRKAKEEMEKWEALQVRWVFLFRNASSITQRLQDMQNHG....SYGA-.LRCL....K.GIEDAVVQQQMG.......QLESLLRSM.KNVLEEFWGCVLTFEKLHRDGLQLLE-----VESSKR.RVEERIGVKPCIADCLEGLSIVYDMHQS.-.........-..----------.---..------------dpgdlnalqylv........
B4DRQ5_HUMAN/74-240              ..............EALKKCFPVVEEQQGLWQSALRDCQPLLSSLSNLAEQLQAAQNLR....FEDVPaLRAF....P.DLKERLRRKQLV.......AGDIVLDKL.GERLAILLKVRDMVSSHVERVFQIYEQHA--DTVGID.AVLQPSAVSPSVADMLEWLQDIERHYRK.S.........Y..LKRKYLLSSI.QWG..DLANIQALPKAW....................
B8LRF9_PICSI/50-214              ..............KKYEQKYRKAREEMDKWDALQLRLLKQFRNAAAIIERLKVLGDKE....NYGV-.LKVF....S.HIAKELPAKQVE.......SLEFIFVSM.RSTLDEFNKVVKSLKKMWQDGCHLLKGET--LQPTLQ.QIQMRVGLRPSLSDCLDGLKAIYEMHLS.E.........Y..LLKVSIISAL.SYD..SRAGDVAALQ--av..................
H2N7Y0_PONAB/12-178              ..............EALKKCFPVVEEQQGLWQSALRDCQPLLSSLSNLAEQLQAAQNLR....FEDVPaLRAF....P.DLKERLRRKQLA.......AGDIVLDKL.GERLAVLLKVRDVVSSHVERVFQIYEQHA--DTVGID.AVLQPSAVSPSVADMLEWLQDIERHYRK.S.........Y..LKRKYLLSSI.QWG..DLANIQALPEAW....................
E5S2G4_TRISP/726-889             ............ea---RRTFRQIRRLIELAKEMESDGLERIDFLGNLLMQRQSVEEVD....LDGSP.LASL....P.EFQTTLMAEIDM.......EVTSVFANL.MEMVIHCQNVCAELERDLNTANWHSENQV------EK.SARLATPFWPAVDQLQMWASEIVVMYSA.D.........L..HRRKSDLDVL.FVD..TLTPLTKV----tqlkqnw.............
G3T9P8_LOXAF/12-178              ..............EALRQCFPAVEEQQGLWRSTLSDCQPLVASLSNLAEQLQAARNVR....FDDVPpLRAF....P.DLEEQLRRKQLA.......AGDTVLDKL.GERLATLLKVRDTVSSYVEQVFQVYEQHA--DAVGID.AVLQPSAVSPSLADMLEWLQDIERHYRN.S.........Y..MKRKYLLSSI.HWG..DLANIQALPKAW....................
H2M1W3_ORYLA/14-181              ..............QAFRNSFAALESNQRLWGSELAECSPLLGSLGNLAEQMRALSNVR....VSSTP.LGTF....P.KLEERLRFKLQE.......AADTVLEKL.NEKMCRLQSARDAISNQVRSVMQLYEQNA--TSLDLQ.AVTERSAVTPSVADMLEWLQDAERHYRQ.Q.........YpfLQRKVLLQTL.RPN..DLALLESLPERW....................
H3AS34_LATCH/13-178              ..............QALRKCFQVISQQEAVWQSTLSECSPLLHSLGNLGEQLQSCNTVA....LKKTP.LKDF....L.DLEQCLKHKLIM.......AMECVLEKL.SGKMAFLQKVRDTITNQVATVFQLYEQHT--GALELS.TITERSAVTPSLANMMEWLQDIERFYRR.R.........Y..LKRKLLLQAI.RDD..DLSYIQALPESW....................
D7UDC1_VITVI/6-170               ..............KKYQQKFRKVRDETKRWDELQSRLLSQFRNASSIIERLQSIQNSK....NYGT-.LKCI....D.GIGDAVLRKQME.......SLETILLSL.KKTLKEFHGIVLSLEKIVRDGRQLVKG--GSVKLTMK.QLQQRIGVKPSLADCLDGLSLLHEMHQS.E.........Y..LLKSSVVSAL.STL..TLKPSASDLG--al..................
E2AIM6_CAMFO/7-150               ............ac--LVRYFARLQKLDEKWKELSAKAERPLEALANQAEQFRHVANVN....INETE.NDMD....G.ETRERLMFKILM.......GLEDEIALL.QDILTQFNDANQDLKNYLIKLENARSQVS-LKDETMQ.ELIKGTSYRPKLNLLLEWAVESFQFYHN.M.........Y..L---------.---..------------l...................
G3WJ24_SARHA/14-179              ............dv--LKKAFHVVEHQHGLWKSTLNDCLPLLTSLSNLAEQLQASQNVQ....LEETP.LRAF....P.DLKDRLRGKLLA.......AGDAILDQL.GEKLNSLLQVRDTVSSHVEQVFELYVQKA--DELGLD.IVLQPSAVSPSLADMLAWLQDIDRHYRN.S.........Y..LERKYLLSQI.QWE..NLPNIQTLPQAW....................
I1KYR1_SOYBN/6-166               ..............KKFQSKFRKVREEMSRWDELQSCLISQFRNASHIVDRLQVLQNSN....NYGV-.LNCA....S.GLKDALLVKQIE.......SLRNILVSM.RKTLEEFHCIVLSLDKIHRDSRQQVKG--GSCHLNMK.QLQQQIGIKPSLIYCLDSLMFIHEIYNS.E.........Y..LLKSSVISAL.SEI..AL----------kprcen..............
F7DU41_CALJA/12-178              ..............EALKKCFPVVEEQQGLWQSALLDCQPLLVSLSNLAEQLQAAQNLR....FEDMPaLRTF....P.DLKERLRRKQLA.......AGDIVLDKL.GERLAILLKVQDTVSSHVERVFQIYEQHA--DTVGID.AVLQSSAVSPSVADMLEWLRDIERHYRN.S.........Y..LKRKYLLSSI.QWG..DLANIQALPKAW....................
E1BYL6_CHICK/9-174               ..............EALREWAVAAARRDAAWRAAVAACAPLLASLAGLAAQMRAAQRLA....WDGTP.LGAF....S.ELRERLWRKQRG.......AAEALLEEL.CERREELRAVRDAVGAGAAAVLRLYEERA--AELSLT.EVLRRGPRCPSLADALEGLQDVERYYRH.M.........Y..LEIRLFLLLI.SCD..SLADMEALPQAW....................
I1QW27_ORYGL/6-169               .............r-RVQQRVRKAREEMDRWDDLNSRLLSQFANAAAIVARLPVLEEVK....NYGV-.LRCV....P.NIRENLLGKQME.......SLEIIFVSM.RETVEEFNSIARSLHKALRDTNQMVR---GGSALSAK.QMQLQVGILPTIADCLDGLRTLCEMHQA.E.........Y..ALKSSVISSL.TWT..SSSSDIAAMRQL....................
G3MPP7_9ACAR/16-182              .............k-AFKLVFCSLKEQKLVWEKCMNDARLHLTAIATLREIQVNCRTAK....LAGSElLTRY....P.DIRQRVVRCVEY.......ELFQEKTKL.EFIMKSLKKSQNVFSSSCQQAIKVFEKMS--QDINTE.DIFYRSEIYPSLADMLEWITCVEQQFSS.H.........F..YARELLLEET.NFG..DDYRADAFIKEW....................
G1L2L4_AILME/17-183              ..............EALRKCFPVVEEQQGLWQSSLRDCQLLLASLSNLAEQLQAAQNLR....FEDVPpLRAF....P.DLKERLRRKQLA.......AGDTVLDKL.GERLAALLKVRDTVSRHVEQVLEIYGQHA--GSIGVG.AVLQASAASPSVADMLEWLQDVERHYRG.S.........Y..LKRKYLLSSI.QWG..DLANIQALPKAW....................
C1FHE8_MICSR/7-171               ..............QKFRALFVKANDTLGRWTATQSRASALVVSAAMVIERLPELADDQ....RFGPL.KERF....P.TLPQATREAQAV.......ALDRVMTNL.REEIEYFDELVKELDRLQRNAASLLG---GMDPPPPG.GGGLRRGPTPAVAECVLGLRDLWRIHRD.E.........L..AIKRALVDEL.TCD..ALMSDLEEVKAL....................
A7MB79_BOVIN/12-178              ..............EALRKCFPVVDEQQGLWQSALRDCPPLLVSLSNLAEQLQAAQNLR....FEDVPsLRPF....P.DLQERLRRKQLA.......AGDTILDKL.GERLATLLKVRDVVSSHVERVLQIYEQHA--DTIGLD.AVLQASAASPSVAEMLEWLQDIERHYRN.S.........Y..LKRKYLLSSI.QWE..DLGNIQALPRAW....................
H9GP34_ANOCA/12-179              .............s-ALRKAFRGVQEQYGAWKGTLAAVAPLLDSLSSLAEQAQALQVAD....LDRSP.LRPF....P.GLRGRLQTKHRA.......AAEVLLANLlQKMLPELQKARDTMGTQVTGIFLLCE--APKAELGLE.SLFQRQPLCPSLADMLEWLLDIERLYHQiR.........Y..LEAKLLLLQI.RYE..NLAGMQALPKAW....................
D4AB92_RAT/12-178                ..............EALKKCFPVVEEQQDLWQSTLQDCLPLLSSLSNLAEQLQAAQSLR....FEDVLaLRPF....P.DLQERLRRKQLE.......AGDIVLDKL.TERLATLLRVRNTISSHVEQVFQTYEQHA--DVLDID.TLLRPSVVSPSVTDMLEWLQDIDRHFRS.S.........Y..LKRKHLLSSI.HWG..DLASIQALPKAW....................
C5WRF1_SORBI/6-169               ..............RKVQQRLRKAQEEMNQWDDLNTHLLSYFSNAGTVISRFQALGEDK....NYG-P.LRGV....P.NIREDLVGNQME.......VLELIFVNA.REILEKFNGIVKALNKALHDTKQIVR---GGSALTAK.QMQLRVGILPTIAECLDGFQTLCEMHQA.E.........F..TLKSSIIFLL.TWK..SSSSDTVVLRQL....................
F1R3X4_DANRE/11-176              ..............QELRRGFEALKAAKDAFDGGHAECQELVSSLGNLALQLKALKQVQ....ISKTP.LSGF....P.CLQQRLHYKLSL.......AVDALLAKL.AEKMAALQKVRDAFAQQVFTVVQLYEKNT--DALDIS.VCVSRSAVCPSVSDMLEWLQDADRYYRL.Q.........L..MQSRLLLQTL.TPT..DLTSMETAPNRW....................
A4RYY9_OSTLU/6-175               .............n-AFRDAYGALARCRARWDDAQGASVALLGTAVNAFERLPAIHDAA....RARAV.DGSEilidD.AFASRVVEAQYA.......ALDRVFARL.REECARFDALTRELERAKTDAWTRTR---NLKPPPKR.AGGERSGPQPSIADCVLGLEEAWRMHKD.E.........C..ALKREIVKRAsTCE..DAEELK------mllrlf..............
B6SQG5_MAIZE/6-169               ..............RKVQQRVRKAREEMDQWDDLNTRLLSQFSNAAAVISRLQALGEDK....NYG-P.LRAV....P.NIRVDLIGNQME.......VLELIFVKI.RETLEKFNDVVKALNKALRDTKQMVR---GGSALTAK.QMQLQVGILPSIAECLDGFQTLCEMHHD.E.........F..TLKSSAISLL.TWK..TCSSDIAVLRQL....................
A5C6J5_VITVI/144-246             ............rc---------------------------------------------....-----.----....-.-----VLRKQME.......SLETILLSL.KKTLKEFHGIVSSLEKIVRDGRQLVKG--GSVKLIMK.QLQQRIGVKPSLADCLDGLSLLHEMHQS.E.........Y..LLKSSVVSAL.STF..ALK---------psai................
E1ZHM8_CHLVA/8-92                ..............EKLRQLYGKVEADVKRWTTLQEEALSLLRTTANVLARLPALEDAG....SYGT-.LAPL....P.GLPRLLLAKQLV.......ALDELIAQL.QEFLDGMQ-----------------------------.----------------------------.-.........-..----------.---..------------as..................
Y5382_ARATH/6-167                ..............RKWQQKFRKGKEEMEKWEALQVRWVSLFRNASSIIQRLQEMQNHG....SYGA-.LRCL....K.GIEDAVVQQQMG.......QLESLLRSM.KNVMEEFWGCVLTFEKLHRDGLQLRE--I---ESSKR.RVEERIGVKPCITDCLEGLSILYDMHQS.E.........Y..HLKSSILSVL.SCL..ILKPS-------pgdlnal.............
#=GC seq_cons                    ..............ptl+ppF.hlccppshWpsshpcs.shlsuLusLsEQLpAhpslc....htsss.LpsF....P.sLp-RLhtKQht.......Ah-hlLspL.tEpLspL.pVpcslsptlcpshplhcpps..sslslc.slhptuulsPSlADhLEWLpDl-RaY+p.p.........Y..lp+c.lLssl.phs..sLsshpuh.pth....................
//
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