#=GF ID COG2
#=GF AC PF06148.6
#=GF DE COG (conserved oligomeric Golgi) complex component, COG2
#=GF AU Finn RD
#=GF SE Pfam-B_9559 (release 9.0)
#=GF GA 24.90 24.90;
#=GF TC 24.90 24.90;
#=GF NC 24.80 24.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 11980916
#=GF RT Characterization of a mammalian Golgi-localized protein complex,
#=GF RT COG, that is required for normal Golgi morphology and function.
#=GF RA Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton
#=GF RA JE, Heuser JE, Krieger M, Waters MG;
#=GF RL J Cell Biol 2002;157:405-415.
#=GF RN [2]
#=GF RM 17565980
#=GF RT Structural analysis of conserved oligomeric Golgi complex
#=GF RT subunit 2.
#=GF RA Cavanaugh LF, Chen X, Richardson BC, Ungar D, Pelczer I, Rizo J,
#=GF RA Hughson FM;
#=GF RL J Biol Chem. 2007;282:23418-23426.
#=GF DR INTERPRO; IPR024602;
#=GF CC The COG complex comprises eight proteins COG1-8. The COG complex
#=GF CC plays critical roles in Golgi structure and function [1]. The
#=GF CC proposed function of the complex is to mediate the initial
#=GF CC physical contact between transport vesicles and their membrane
#=GF CC targets. A comparable role in tethering vesicles has been
#=GF CC suggested for at least six additional large multisubunit
#=GF CC complexes, including the exocyst, a complex that mediates
#=GF CC trafficking to the plasma membrane. COG2 structure reveals a
#=GF CC six-helix bundle with few conserved surface features but a
#=GF CC general resemblance to recently determined crystal structures of
#=GF CC four different exocyst subunits. These bundles inCOG2 may act as
#=GF CC platforms for interaction with other trafficing proteins
#=GF CC including SNAREs (soluble N-ethylmaleimide factor attachment
#=GF CC protein receptors) and Rabs [2].
#=GF SQ 316
#=GS Q3TAN4_MOUSE/15-147 AC Q3TAN4.1
#=GS B7Z2Y2_HUMAN/1-88 AC B7Z2Y2.1
#=GS E9CJE7_CAPO3/29-209 AC E9CJE7.1
#=GS G0UCV4_TRYVI/35-223 AC G0UCV4.1
#=GS COG2_DICDI/53-185 AC Q54UC2.1
#=GS D3BKL8_POLPA/52-184 AC D3BKL8.1
#=GS C9SNL1_VERA1/37-129 AC C9SNL1.1
#=GS Q4WEM9_ASPFU/68-201 AC Q4WEM9.1
#=GS F7W2R4_SORMK/124-241 AC F7W2R4.1
#=GS H3HWT6_STRPU/1-123 AC H3HWT6.1
#=GS F6TLT4_MACMU/15-147 AC F6TLT4.1
#=GS H2TPH6_TAKRU/12-144 AC H2TPH6.1
#=GS H0GGN4_9SACH/10-189 AC H0GGN4.1
#=GS G3XLN4_ASPNA/22-155 AC G3XLN4.1
#=GS H3IHY3_STRPU/17-149 AC H3IHY3.1
#=GS H6QRW5_PUCGT/43-175 AC H6QRW5.1
#=GS A6SP25_BOTFB/26-123 AC A6SP25.1
#=GS C0NTP1_AJECG/31-164 AC C0NTP1.1
#=GS E2AX33_CAMFO/15-147 AC E2AX33.1
#=GS C7GUH4_YEAS2/7-176 AC C7GUH4.1
#=GS Q55M87_CRYNB/34-165 AC Q55M87.1
#=GS B4GNT8_DROPE/22-154 AC B4GNT8.1
#=GS E7KCJ1_YEASA/7-176 AC E7KCJ1.1
#=GS G3WZ34_SARHA/15-147 AC G3WZ34.1
#=GS E6ZM72_SPORE/29-184 AC E6ZM72.1
#=GS G2X4E2_VERDV/35-167 AC G2X4E2.1
#=GS COG2_MOUSE/15-147 AC Q921L5.2
#=GS C4Y9X2_CLAL4/33-170 AC C4Y9X2.1
#=GS C5JFC1_AJEDS/31-164 AC C5JFC1.1
#=GS F0W3M8_9STRA/23-155 AC F0W3M8.1
#=GS H6BUY7_EXODN/26-159 AC H6BUY7.1
#=GS C4JM13_UNCRE/27-160 AC C4JM13.1
#=GS F4P172_BATDJ/29-160 AC F4P172.1
#=GS E9J4R1_SOLIN/15-147 AC E9J4R1.1
#=GS F8MDU0_NEUT8/126-241 AC F8MDU0.1
#=GS Q4XLC2_PLACH/26-162 AC Q4XLC2.1
#=GS Q4DNE3_TRYCC/72-246 AC Q4DNE3.1
#=GS B4KAP9_DROMO/20-152 AC B4KAP9.1
#=GS D0A8R7_TRYB9/46-232 AC D0A8R7.1
#=GS D8LMA5_ECTSI/10-143 AC D8LMA5.1
#=GS B2VUT1_PYRTR/39-146 AC B2VUT1.1
#=GS Q84LH7_ORYSJ/24-156 AC Q84LH7.1
#=GS G1SDD2_RABIT/15-147 AC G1SDD2.1
#=GS D8REB4_SELML/1-98 AC D8REB4.1
#=GS Q7QFV1_ANOGA/25-157 AC Q7QFV1.4
#=GS G7JLF2_MEDTR/25-157 AC G7JLF2.1
#=GS E6R5I8_CRYGW/34-165 AC E6R5I8.1
#=GS D8TFL9_SELML/1-69 AC D8TFL9.1
#=GS G7XN41_ASPKW/27-160 AC G7XN41.1
#=GS COG2_SCHPO/14-151 AC O59705.2
#=GS C1E3L3_MICSR/35-168 AC C1E3L3.1
#=GS F7FGY0_ORNAN/1-125 AC F7FGY0.1
#=GS H2ZX23_LATCH/15-147 AC H2ZX23.1
#=GS H2XUV6_CIOIN/19-151 AC H2XUV6.1
#=GS F2QX43_PICP7/24-177 AC F2QX43.1
#=GS G2YDR1_BOTF4/26-158 AC G2YDR1.1
#=GS I1MUP1_SOYBN/25-157 AC I1MUP1.1
#=GS H0VNM8_CAVPO/15-147 AC H0VNM8.1
#=GS H9GU64_ANOCA/1-134 AC H9GU64.1
#=GS F9XIE4_MYCGM/35-168 AC F9XIE4.1
#=GS Q01CT5_OSTTA/52-184 AC Q01CT5.1
#=GS A6ZUD3_YEAS7/7-176 AC A6ZUD3.1
#=GS E9E856_METAQ/42-174 AC E9E856.1
#=GS E7Q444_YEASB/8-176 AC E7Q444.1
#=GS B1ALW7_HUMAN/15-147 AC B1ALW7.1
#=GS C4LZD8_ENTHI/4-159 AC C4LZD8.1
#=GS D2HXR7_AILME/1-125 AC D2HXR7.1
#=GS Q2GWP6_CHAGB/56-194 AC Q2GWP6.1
#=GS H3DXT3_PRIPA/21-147 AC H3DXT3.1
#=GS Q2UA29_ASPOR/27-160 AC Q2UA29.1
#=GS A2QUK9_ASPNC/182-315 AC A2QUK9.1
#=GS B0ELM9_ENTDS/4-159 AC B0ELM9.1
#=GS A7TEZ2_VANPO/15-165 AC A7TEZ2.1
#=GS A5AZC7_VITVI/23-155 AC A5AZC7.1
#=GS G2QVJ6_THITE/61-199 AC G2QVJ6.1
#=GS B8MDL0_TALSN/27-160 AC B8MDL0.1
#=GS A8N6Z4_COPC7/57-188 AC A8N6Z4.2
#=GS A4IE16_LEIIN/77-259 AC A4IE16.1
#=GS G7E6D6_MIXOS/54-224 AC G7E6D6.1
#=GS A1C4Y0_ASPCL/32-165 AC A1C4Y0.1
#=GS C0S8B4_PARBP/33-166 AC C0S8B4.1
#=GS E1ZBJ6_CHLVA/30-162 AC E1ZBJ6.1
#=GS C1GJT2_PARBD/33-166 AC C1GJT2.1
#=GS Q4DIS5_TRYCC/36-210 AC Q4DIS5.1
#=GS H9IL20_ATTCE/15-147 AC H9IL20.1
#=GS F7FGY6_ORNAN/1-125 AC F7FGY6.1
#=GS COG2_DROME/22-154 AC Q9VF78.1
#=GS G9P4M6_HYPAI/43-175 AC G9P4M6.1
#=GS F2RNW8_TRIT1/25-158 AC F2RNW8.1
#=GS A3LQZ6_PICST/19-151 AC A3LQZ6.2
#=GS G0RHK3_HYPJQ/40-172 AC G0RHK3.1
#=GS H2LLR6_ORYLA/15-147 AC H2LLR6.1
#=GS G3R4J5_GORGO/15-147 AC G3R4J5.1
#=GS A8J1K6_CHLRE/27-159 AC A8J1K6.1
#=GS F4X4S0_ACREC/15-147 AC F4X4S0.1
#=GS E1GF00_LOALO/1-128 AC E1GF00.1
#=GS E5L9S2_BACOL/20-152 AC E5L9S2.1
#=GS C5FI29_ARTOC/25-158 AC C5FI29.1
#=GS G2WEK2_YEASK/7-176 AC G2WEK2.1
#=GS E9BUY7_LEIDB/77-259 AC E9BUY7.1
#=GS E2LPL2_MONPE/25-133 AC E2LPL2.1
#=GS Q6BQ04_DEBHA/21-156 AC Q6BQ04.2
#=GS E3QVM8_COLGM/41-173 AC E3QVM8.1
#=GS Q29BE0_DROPS/22-154 AC Q29BE0.2
#=GS Q9SZX4_ARATH/31-163 AC Q9SZX4.1
#=GS D4AR07_ARTBC/25-158 AC D4AR07.1
#=GS G8JTX8_ERECY/5-166 AC G8JTX8.1
#=GS Q9ASS9_ARATH/31-163 AC Q9ASS9.1
#=GS G7J8E7_MEDTR/20-92 AC G7J8E7.1
#=GS H2Q1B6_PANTR/15-147 AC H2Q1B6.1
#=GS F0XNW5_GROCL/47-189 AC F0XNW5.1
#=GS C6HEE8_AJECH/31-164 AC C6HEE8.1
#=GS G8Y7T1_PICSO/40-173 AC G8Y7T1.1
#=GS F8PUX6_SERL3/57-186 AC F8PUX6.1
#=GS G4N4C1_MAGO7/53-195 AC G4N4C1.1
#=GS H8X254_9ASCO/26-158 AC H8X254.1
#=GS G1LSZ7_AILME/15-147 AC G1LSZ7.1
#=GS A7EEQ7_SCLS1/26-140 AC A7EEQ7.1
#=GS Q8C205_MOUSE/15-147 AC Q8C205.1
#=GS G0S5N8_CHATD/53-191 AC G0S5N8.1
#=GS F2SNQ6_TRIRC/25-158 AC F2SNQ6.1
#=GS E3RZL9_PYRTT/30-163 AC E3RZL9.1
#=GS B4M5Z3_DROVI/20-152 AC B4M5Z3.1
#=GS B9RAH9_RICCO/26-158 AC B9RAH9.1
#=GS G3BBP8_CANTC/4-144 AC G3BBP8.1
#=GS B8PIP2_POSPM/32-191 AC B8PIP2.1
#=GS E7R5Z2_PICAD/12-153 AC E7R5Z2.1
#=GS G4UG30_NEUT9/126-241 AC G4UG30.1
#=GS G4TBE6_PIRID/11-173 AC G4TBE6.1
#=GS B8NQF9_ASPFN/27-160 AC B8NQF9.1
#=GS H2N3F3_PONAB/15-147 AC H2N3F3.1
#=GS E9F1Y8_METAR/42-174 AC E9F1Y8.1
#=GS E3MK88_CAERE/24-156 AC E3MK88.1
#=GS G7M108_9CLOT/1-101 AC G7M108.1
#=GS E2L3A1_MONPE/25-95 AC E2L3A1.1
#=GS F7BFE3_XENTR/15-147 AC F7BFE3.1
#=GS Q3TZZ9_MOUSE/15-147 AC Q3TZZ9.1
#=GS B9I3P7_POPTR/28-160 AC B9I3P7.1
#=GS I0YMH7_9CHLO/25-157 AC I0YMH7.1
#=GS D2V7C9_NAEGR/22-174 AC D2V7C9.1
#=GS C5M446_CANTT/21-153 AC C5M446.1
#=GS F0Y1H7_AURAN/621-737 AC F0Y1H7.1
#=GS A4HQC3_LEIBR/80-263 AC A4HQC3.1
#=GS D8R5E4_SELML/15-147 AC D8R5E4.1
#=GS E9DBC6_COCPS/27-160 AC E9DBC6.1
#=GS G3MLU7_9ACAR/17-149 AC G3MLU7.1
#=GS H2XKN8_CIOIN/11-143 AC H2XKN8.1
#=GS E9AU39_LEIMU/77-258 AC E9AU39.1
#=GS E3X034_ANODA/23-155 AC E3X034.1
#=GS D8TL51_VOLCA/26-158 AC D8TL51.1
#=GS B2Q3J4_PROST/558-599 AC B2Q3J4.1
#=GS Q1K6A0_NEUCR/131-248 AC Q1K6A0.1
#=GS F1RG46_PIG/1-69 AC F1RG46.1
#=GS A1CZV9_NEOFI/67-200 AC A1CZV9.1
#=GS G0SX59_RHOG2/45-196 AC G0SX59.1
#=GS G5BQI4_HETGA/15-147 AC G5BQI4.1
#=GS H0ZI76_TAEGU/4-136 AC H0ZI76.1
#=GS Q8II59_PLAF7/21-151 AC Q8II59.1
#=GS Q6ZM82_DANRE/11-143 AC Q6ZM82.2
#=GS Q5K8I4_CRYNJ/34-165 AC Q5K8I4.1
#=GS C0PHW0_MAIZE/19-151 AC C0PHW0.1
#=GS Q4RND9_TETNG/12-98 AC Q4RND9.1
#=GS D8SFL5_SELML/15-147 AC D8SFL5.1
#=GS B6ADX4_CRYMR/13-140 AC B6ADX4.1
#=GS A8WN13_CAEBR/23-155 AC A8WN13.1
#=GS G8ZX24_TORDC/5-170 AC G8ZX24.1
#=GS H2KU27_CLOSI/1249-1382 AC H2KU27.1
#=GS E7KZA8_TRYCR/72-246 AC E7KZA8.1
#=GS I1FLD1_AMPQE/461-581 AC I1FLD1.1
#=GS G7JLF3_MEDTR/25-157 AC G7JLF3.1
#=GS E2BXG1_HARSA/15-147 AC E2BXG1.1
#=GS B5DG14_SALSA/10-142 AC B5DG14.1
#=GS A7RJ10_NEMVE/17-149 AC A7RJ10.1
#=GS E1C7Y1_CHICK/15-147 AC E1C7Y1.1
#=GS B6JW11_SCHJY/13-151 AC B6JW11.1
#=GS COG2_HUMAN/15-147 AC Q14746.1
#=GS B6HK70_PENCW/26-159 AC B6HK70.1
#=GS B2B635_PODAN/91-229 AC B2B635.1
#=GS Q4RND9_TETNG/96-220 AC Q4RND9.1
#=GS C5DJ84_LACTC/15-162 AC C5DJ84.1
#=GS Q5A221_CANAL/21-153 AC Q5A221.1
#=GS H0EVU8_GLAL7/26-158 AC H0EVU8.1
#=GS D8STH1_SELML/199-280 AC D8STH1.1
#=GS Q870V4_NEUCS/131-248 AC Q870V4.1
#=GS F6WMU6_ORNAN/1-125 AC F6WMU6.1
#=GS H2YCH7_CIOSA/11-143 AC H2YCH7.1
#=GS G3JPB3_CORMM/38-170 AC G3JPB3.1
#=GS I1GKW4_BRADI/29-161 AC I1GKW4.1
#=GS F6SW28_HORSE/15-147 AC F6SW28.1
#=GS D7SGW9_VITVI/23-155 AC D7SGW9.1
#=GS H1VII0_COLHI/40-172 AC H1VII0.1
#=GS A0CKT7_PARTE/12-141 AC A0CKT7.1
#=GS E4URX8_ARTGP/25-158 AC E4URX8.1
#=GS D8RHU5_SELML/1-98 AC D8RHU5.1
#=GS B9IF93_POPTR/30-162 AC B9IF93.1
#=GS F1P8W5_CANFA/10-147 AC F1P8W5.1
#=GS C1N3K6_MICPC/26-159 AC C1N3K6.1
#=GS B7PSB3_IXOSC/17-149 AC B7PSB3.1
#=GS G8BBN1_CANPC/24-158 AC G8BBN1.1
#=GS B3LIA9_YEAS1/11-176 AC B3LIA9.1
#=GS Q0C728_AEDAE/17-149 AC Q0C728.1
#=GS C5WSX1_SORBI/27-159 AC C5WSX1.1
#=GS Q7ZUD7_DANRE/11-143 AC Q7ZUD7.1
#=GS C5GHY8_AJEDR/31-164 AC C5GHY8.1
#=GS I1GE75_AMPQE/49-167 AC I1GE75.1
#=GS B9WL69_CANDC/22-158 AC B9WL69.1
#=GS F6ZMV7_MONDO/15-147 AC F6ZMV7.1
#=GS A9V223_MONBE/2-132 AC A9V223.1
#=GS E4Y086_OIKDI/26-157 AC E4Y086.1
#=GS E7QF35_YEASZ/7-176 AC E7QF35.1
#=GS G4VDD4_SCHMA/1250-1383 AC G4VDD4.1
#=GS E3RPR2_PYRTT/39-146 AC E3RPR2.1
#=GS B0D0M4_LACBS/49-180 AC B0D0M4.1
#=GS G0V1W2_TRYCI/35-217 AC G0V1W2.1
#=GS Q75EH5_ASHGO/16-164 AC Q75EH5.1
#=GS I1PHD6_ORYGL/24-156 AC I1PHD6.1
#=GS B8ANN3_ORYSI/24-156 AC B8ANN3.1
#=GS B3MST9_DROAN/21-153 AC B3MST9.1
#=GS Q4Q0F6_LEIMA/80-262 AC Q4Q0F6.1
#=GS F2PS01_TRIEC/25-158 AC F2PS01.1
#=GS F4JRR1_ARATH/31-163 AC F4JRR1.1
#=GS H2YCH5_CIOSA/11-143 AC H2YCH5.1
#=GS A2DSK9_TRIVA/4-138 AC A2DSK9.1
#=GS B4JU40_DROGR/20-152 AC B4JU40.1
#=GS C3XRH4_BRAFL/13-146 AC C3XRH4.1
#=GS Q0TYI9_PHANO/26-159 AC Q0TYI9.2
#=GS F0VIR0_NEOCL/72-189 AC F0VIR0.1
#=GS A4RU98_OSTLU/57-189 AC A4RU98.1
#=GS H9FRE0_MACMU/15-147 AC H9FRE0.1
#=GS F2TFR3_AJEDA/31-164 AC F2TFR3.1
#=GS B0Y2V4_ASPFC/68-201 AC B0Y2V4.1
#=GS G3AI78_SPAPN/2-151 AC G3AI78.1
#=GS A6QT44_AJECN/31-164 AC A6QT44.1
#=GS H9KMM4_APIME/15-147 AC H9KMM4.1
#=GS E0W329_PEDHC/16-148 AC E0W329.1
#=GS D5GMB3_TUBMM/26-132 AC D5GMB3.1
#=GS F1MQ89_BOVIN/15-147 AC F1MQ89.1
#=GS G7MFR5_MACMU/15-147 AC G7MFR5.1
#=GS D8T6K6_SELML/1-69 AC D8T6K6.1
#=GS B2WLY9_PYRTR/30-163 AC B2WLY9.1
#=GS B0WLZ0_CULQU/17-149 AC B0WLZ0.1
#=GS A8PRA6_MALGO/6-156 AC A8PRA6.1
#=GS B5VJ66_YEAS6/10-189 AC B5VJ66.1
#=GS Q5A272_CANAL/21-153 AC Q5A272.1
#=GS B3P0W0_DROER/22-154 AC B3P0W0.1
#=GS G3SPU2_LOXAF/15-147 AC G3SPU2.1
#=GS F2E2E1_HORVD/37-169 AC F2E2E1.1
#=GS H2YCH6_CIOSA/1-125 AC H2YCH6.1
#=GS D7MGM2_ARALL/31-163 AC D7MGM2.1
#=GS H2AS74_KAZAF/19-184 AC H2AS74.1
#=GS H2W479_CAEJA/24-114 AC H2W479.1
#=GS D8QCD3_SCHCM/40-171 AC D8QCD3.1
#=GS G3P5P9_GASAC/15-147 AC G3P5P9.1
#=GS F6TD23_CALJA/15-147 AC F6TD23.1
#=GS F9FDQ5_FUSOF/42-174 AC F9FDQ5.1
#=GS G8F2E0_MACFA/15-147 AC G8F2E0.1
#=GS C5DR02_ZYGRC/4-163 AC C5DR02.1
#=GS C4R3U8_PICPG/24-177 AC C4R3U8.1
#=GS D0N3C0_PHYIT/6-138 AC D0N3C0.1
#=GS G0WIH4_NAUDC/3-174 AC G0WIH4.1
#=GS Q5BZC0_SCHJA/41-174 AC Q5BZC0.2
#=GS G9MZD3_HYPVG/43-175 AC G9MZD3.1
#=GS I1RPG2_GIBZE/43-175 AC I1RPG2.1
#=GS G6D862_DANPL/17-149 AC G6D862.1
#=GS A9SCH7_PHYPA/34-166 AC A9SCH7.1
#=GS D8TLK5_VOLCA/174-267 AC D8TLK5.1
#=GS Q6CGB8_YARLI/16-136 AC Q6CGB8.1
#=GS B4PS38_DROYA/22-154 AC B4PS38.1
#=GS A9S4S7_PHYPA/34-166 AC A9S4S7.1
#=GS Q0CE29_ASPTN/87-220 AC Q0CE29.1
#=GS C8V7E6_EMENI/29-162 AC C8V7E6.1
#=GS D3ZT01_RAT/15-147 AC D3ZT01.1
#=GS Q4P841_USTMA/80-240 AC Q4P841.1
#=GS B4HM21_DROSE/22-154 AC B4HM21.1
#=GS Q7RRR2_PLAYO/32-177 AC Q7RRR2.1
#=GS F1KUU6_ASCSU/32-166 AC F1KUU6.1
#=GS D3ZC30_RAT/15-147 AC D3ZC30.1
#=GS A5DRX4_LODEL/23-155 AC A5DRX4.1
#=GS F0ZWS2_DICPU/82-214 AC F0ZWS2.1
#=GS E5A9D0_LEPMJ/32-165 AC E5A9D0.1
#=GS A8QDF1_BRUMA/33-165 AC A8QDF1.1
#=GS C8Z911_YEAS8/7-176 AC C8Z911.1
#=GS F4QE05_DICFS/47-179 AC F4QE05.1
#=GS A5DQ90_PICGU/9-142 AC A5DQ90.2
#=GS F6RGY5_HORSE/15-147 AC F6RGY5.1
#=GS E9Q5N6_MOUSE/15-147 AC E9Q5N6.1
#=GS Q5AU04_EMENI/25-158 AC Q5AU04.1
#=GS H3BJK5_MOUSE/15-101 AC H3BJK5.1
#=GS COG2_YEAST/7-176 AC P53271.2
#=GS COG2_YEAST/7-176 DR PDB; 2JQQ A; 109-176;
#=GS H9J6D4_BOMMO/1-103 AC H9J6D4.1
#=GS H0X4H4_OTOGA/15-147 AC H0X4H4.1
#=GS C5P4R2_COCP7/27-160 AC C5P4R2.1
#=GS COG2_CAEEL/24-156 AC Q21444.1
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E9Q5N6_MOUSE/15-147 ............................................LCFDKDEFMK..................................................EDF.D.V...DHFVS..........D...C..........R.....K..RV..QLEE...L...R...D...D...LELY...Y....KLLKTAMVELINKDYAD.FVN.......LST...NLVG..M.D.....R....A.....LNQL..................SV..PL...G...Q...L...R.E..E...V..LS.L..RS.S.....V.SEGILAVDERMSKQEDIRKKK.......MSVLRLIQV.IRSVEKIEKIL...............................................................................................................................
Q5AU04_EMENI/25-158 ..........................................ep--LSRSSFLA..................................................PDF.D.P...ATYLS..........S..lT..........N.....R..HQ..SLED...L...R...Q...E...LRNL...D....QLLSRELLDLVNENYQD.FLS.......LGS...ALEG..G.E.....E....K.....VEQV..................RV..GL...L...A...F...Q.R..D...V..QS.I..RD.K.....V.EARQREVAGLLNEKKRLRANA.......NIGCALLEF.ADRIEELEKR-l..............................................................................................................................
H3BJK5_MOUSE/15-101 ............................................LCFDKDEFMK..................................................EDF.D.V...DHFVS..........D...C..........R.....K..RV..QLEE...L...R...D...D...LELY...Y....KLLKTAMVELINKDYAD.FVN.......LST...NLVG..M.D.....R....A.....LNQL..................SV..PL...G...Q...L...R.E..E...V..L-.-..--.-.....-.---------------------.......---------.-----------s..............................................................................................................................
COG2_YEAST/7-176 ..........deldldlpvtaeiskelfateiekyresetngtd---------V..................................................DNF.D.V...DRFLV..........Q..kN..........F.....H..YL..PLDS...L...I...R...D...LSGL...S....QKMVQTLLEQIRSNYDD.YLT.......FSN...TYTD..E.E.....N....Etl.inLEKT..................QS..DL...Q...K...F...M.T..Q...L..DH.L.iKD.D.....I.SNTQEIIKDVLEYLKKLDEIY.......GSLRNHSQL.T----------ealslgkrlskslhem...............................................................................................................
#=GR COG2_YEAST/7-176 SS ..........XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---------X..................................................XXX.X.X...XXXXX..........X..XX..........X.....X..XX..XXXX...X...X...X...X...XXXX...X....XXXXXXXXXXXXXXXXX.XXX.......XXX...XXXX..X.X.....X....XXX.XXXX-H..................HH..HH...H...H...H...H.H..H...H..HH.H.HHH.S.....-.STTHHHHHHHHHHHHHHHHHH.......HT-SSSSHH.H----------HHHHHHHHHHHHHHHH...............................................................................................................
H9J6D4_BOMMO/1-103 ............................................----------..................................................---.-.-...-----..........-...-..........-.....-..--..----...M...R...D...D...LGMY...L....KVLRLAMIELINKDYAN.FVN.......LCA...TLIG..F.D.....K....A.....IAKV..................HV..PL...E...Q...L...N.K..D...V..LN.V..KR.S.....L.EDAMKETSMWMSQRHNLQSKK.......QLLKYYSQT.INSLNRLDNV-l..............................................................................................................................
H0X4H4_OTOGA/15-147 ............................................LCFDKEEFMK..................................................EDF.D.V...DHFVS..........D...C..........R.....K..RV..QLEE...L...R...D...D...LELY...Y....RLLKTAMVELINKDYAD.FVN.......LST...NLVG..M.D.....K....A.....LNQL..................SV..PL...G...Q...L...R.E..E...V..LS.L..RS.S.....V.SEGIRAVDERMSKQEDIRKKK.......MCVLRLIQV.IRSVEKIEKIL...............................................................................................................................
C5P4R2_COCP7/27-160 ..........................................kp--LSRSSFTT..................................................PDF.D.P...AKFLS..........S..lS..........N.....R..HQ..SLAD...L...Q...T...E...LRDL...S....QSLSKELLNLVNDNYQD.FLS.......LGT...ALKG..G.E.....E....R.....VEEI..................RA..VL...L...G...F...Q.R..D...V..QS.V..KE.K.....F.ENRTATIKGLLDDKKRLRSDI.......AIGYYLLDI.AEKIELLERK-l..............................................................................................................................
COG2_CAEEL/24-156 ............................................LCFNKTHFNR..................................................EDF.N.V...ERFMN..........L...A..........R.....Q..KS..DLKT...I...Q...Q...D...LRLY...L....KSVQNSMIELINDDYAD.FVH.......LSS...NLVS..L.Q.....D....S.....LNKI..................EQ..DI...N...R...I...W.D..E...F..KE.S..TR.E.....S.VGMAERIEQKCDELCSNREKQ.......IEIRDRIYF.LVAIEKLSEM-l..............................................................................................................................
C1H0J1_PARBA/33-166 ..........................................kp--LSRSSFLS..................................................PTF.D.P...ATFLS..........S..lT..........N.....R..HQ..TLSD...L...Q...T...E...LREL...S....QSLNNELLDLVNENYQD.FLS.......LGS...ALRG..G.E.....E....K.....VEQV..................RV..GL...L...G...F...Q.R..D...V..KG.L..RD.L.....F.EKRIGEMAELVEEKKKLRKGI.......MVAHELLDV.EYSIGELEES-l..............................................................................................................................
Q383M1_TRYB2/46-232 ............................................LCFGEHEFGVvldsdnttehdtegecisaganyv..nasddaeqmdfehhnepgetmlaaFEF.D.P...VQFVQ..........N..kL..........S.....H..GV..PLDD...L...C...R...D...LETY...M....SLLNKIILRHVNTDVHDaFVK.......VSG...HLVG..M.Q.....D....D.....LRLV..................QH..PV...A...V...A...V.K..K...V..EE.N..IA.K.....L.NEMENTVTSQIAEATELELMRif...dvNFLKVLLLY.DHLCVQLEALP...............................................................................................................................
D6W7T3_TRICA/8-138 ..........................................vw----KESFFK..................................................ENF.N.V...DQCLS..........K...Y..........T.....L..KS..DLET...L...R...N...D...LKNY...G....NDLHQQMAEILKTETEA.IVN.......LAE...YLTN..L.N.....S....K.....IDDL..................SL..PL...R...Q...L...R.E..E...I..KT.L..YD.L.....I.KSAEESYFTTLETIKNNNTRR.......NYLNLKFGI.-----------issalyidnmi....................................................................................................................
F7HW85_CALJA/1-88 ............................................----------..................................................---.-.-...-----..........-...-..........-.....-..--..----...-...-...-...-...----...-....------MVELINKDYAD.FVN.......LST...NLVG..M.D.....K....A.....LNQL..................SV..PL...G...Q...L...R.E..E...V..LS.L..RS.S.....V.SEGIRAVDERMCKQEDIRKKK.......MCVLRLIQV.IRSVEKIEKIL...............................................................................................................................
H3HUS8_STRPU/1-44 ............................................----------..................................................---.-.-...-----..........-...-..........-.....-..--..----...-...-...-...-...----...-....------MVELINKDYAD.FVN.......LSS...NLVG..M.D.....K....A.....IGNL..................SV..PL...G...Q...L...R.E..E...V..M-.-..--.-.....-.---------------------.......---------.-----------vsf............................................................................................................................
F6TLS1_MACMU/15-147 ............................................LCFDKDEFMK..................................................EDF.D.V...DHFVS..........D...C..........R.....K..RV..QLEE...L...R...D...D...LELY...Y....KLLKTAMVELINKDYAD.FVN.......LST...NLVG..M.D.....K....A.....LNQL..................SV..PL...G...Q...L...R.E..E...V..LS.L..RS.S.....V.SEGIRAVDERVSKQEDIRKKK.......MCVLRLIQV.IRSVEKIEKIL...............................................................................................................................
G1PBX4_MYOLU/15-147 ............................................LCFDKDEFMK..................................................EDF.D.V...DHFVS..........D...C..........R.....K..RV..QLEE...L...R...D...D...LELY...Y....KLLKTAMVELINKDYAD.FVN.......LST...NLVG..M.D.....K....V.....LNQL..................SV..PL...G...Q...L...R.E..E...V..LS.L..RS.S.....V.SEGIRAVDERMSKQEDIRGKK.......MCVLRLIQV.IRSVEKIEKIL...............................................................................................................................
C7YV16_NECH7/46-178 .........................................alp----RADFLA..................................................PNF.Q.P...AAYLS..........A..lP..........N.....R..HQ..TLED...L...R...S...D...LRDR...S....AAISSELLELVNSNYTA.FLS.......LGS...ELRG..G.D.....D....K.....VEDV..................KV..SL...L...G...F...R.R..A...V..EE.V..KG.R.....V.SSRKEETNALNDELRGVRSAI.......EQGRKMIEL.SERLTSLEEH-l..............................................................................................................................
D4DDP3_TRIVH/25-158 .........................................kpi---SRASFLT..................................................PDF.D.A...TTFLA..........S..lS..........N.....R..HQ..SLAD...L...Q...T...E...LREL...N....EALNKELLDLVNENYQE.FLS.......LGA...ALKG..G.Q.....D....K.....VEEI..................RA..GL...L...G...F...Q.R..N...V..QG.I..KD.Q.....F.EAKKKEIRECLDEKKRLRSKI.......SVGYELLDV.AERIELLET--nl.............................................................................................................................
I1K0A3_SOYBN/25-157 ............................................LWFKPASFLS..................................................PDF.D.S...ESYIS..........E...L..........R.....T..FV..PFDT...L...R...S...E...LNSY...L....SSLNHELIDLINRDYAD.FVN.......LST...KLVD..V.D.....A....V.....VVRM..................RA..PL...V...E...L...R.D..K...I..EQ.F..RG.S.....V.EVSLVAIKSRLRQRSEVASAR.......ETLELLLDA.FHVVSKVEKLI...............................................................................................................................
G1QM65_NOMLE/1-126 .........................................ifq----------..................................................EDF.D.V...DHFVS..........D...C..........R.....K..RV..QLEE...L...R...D...D...LELY...Y....KLLKTAMVELINKDYAD.FVN.......LST...NLVG..M.D.....K....A.....LNQL..................SV..PL...G...Q...L...R.E..E...V..LS.L..RS.S.....V.SEGIRAVDERMSKQEDIRKKK.......MCVLRLIQV.IRSVEKIEKIL...............................................................................................................................
C5LCT4_PERM5/6-137 .........................................vpl-----SEFTE..................................................PGA.D.P...VAIIQ..........R..yR..........R.....R..GV..PMTE...L...V...K...S...FKRH...G....NKIQEELVQLINDHYSE.FIG.......LST...KMEE..V.S.....R....K.....TAQL..................RP..PL...S...A...A...L.K..S...S..TA.S..TS.S.....V.KEQVDKAEALMRKKEDIRRER.......RLLGLYYEN.RSLLKKISD--rl.............................................................................................................................
B3S0S2_TRIAD/29-161 ............................................LCFVTEDFVS..................................................EEF.N.V...DGFIT..........S...C..........R.....S..SV..SPEV...L...R...N...D...LKTY...F....DILKSSMVELINKDYAD.FVN.......LST...NLVG..L.D.....K....A.....ISNI..................SA..PL...E...Q...I...K.T..E...V..GS.V..KD.C.....I.GQAMNGINRRLKKRTELREKK.......ARLQRLLNI.SDSVDKIEKLL...............................................................................................................................
F0UQ07_AJEC8/31-164 .........................................kpl---SRASFIS..................................................PNF.D.P...ATFLS..........S..lT..........N.....R..HQ..TLSD...L...Q...T...E...LREL...S....QSLNNELLDLVNENYQD.FLS.......LGS...ALTG..G.E.....E....K.....VEQV..................RV..GL...L...A...F...Q.R..D...V..KG.I..RD.G.....F.EKRIDDISALLEEKKGLRKEV.......MLAYDLLDI.EESIGELEDR-l..............................................................................................................................
B6QFM9_PENMQ/27-160 ..........................................kp--LSRSSFLA..................................................PEF.D.P...ATFLS..........S..lT..........N.....R..HQ..TLED...L...R...Q...E...LREL...S....QGLNKELLDVVNENYQD.FLS.......LGG...ALQG..G.E.....E....K.....VEEI..................SV..GL...L...G...F...Q.R..D...V..AA.I..HA.K.....V.EARKAEMESLLQEKKAYRIKA.......NIGMALLDI.AERIEELEQR-l..............................................................................................................................
E9HN66_DAPPU/12-144 ...........................................v-CFKREIFIQ..................................................DSF.S.A...DVFLQ..........D...L..........W.....N..SV..PLEV...L...R...D...D...LGSY...L....KVLRSAMIELINRDYAD.FVN.......LSG...NLVG..L.D.....I....A.....IANL..................QQ..PL...I...S...M...H.S..D...I..LA.V..EK.V.....L.HNAHSTLLISLSERQCLREQK.......LLLESLMKI.PTSLDNLEKLI...............................................................................................................................
B4NAU2_DROWI/22-154 ............................................LCFDKNEFMK..................................................ANF.S.V...DEFLH..........K...N..........R.....N..AP..SLEQ...L...R...D...N...LGLY...L....KGLRAAMIDLINEDYAD.FVN.......LSA...NLVG..L.D.....Q....S.....IEII..................QR..PL...E...Q...F...R.N..E...I..ES.I..HN.L.....I.DENVSQLRAQLEEKRQLREFK.......RSLQSLKTV.YETTKKLQDL-m..............................................................................................................................
G1X2I7_ARTOA/31-163 ........................................qplp----RSAFIT..................................................TDF.S.A...SSYLA..........S...L..........H.....R..HQ..TLED...L...R...A...E...LRTR...S....KDLERELVELVNRDYAD.FVG.......LGS...SLRG..G.E.....G....K.....VNDL..................KL..GV...M...G...F...A.R..E...I..EG.V..KE.K.....V.VKVSNEMEKDMVVKKEIARKK.......ALARNLLTF.DSRLSQLESLL...............................................................................................................................
F8NV43_SERL9/57-195 ..........................................ls--HDNPYLTA..................................................EPF.D.V...DQFLL..........S...-..........R.....S..YT..SLPD...L...R...S...E...LRDY...L....STLKEELVQLINDDYEA.FIS.......LST...DLKG..E.G.....A....R.....MERL..................RL..PL...N...S...I...K.S..E...I..LE.V..RK.S.....L.QTIQDTTQEKLDERAKIREEKesfllllALLHLLLKI.SESVTRLESLL...............................................................................................................................
C4YL86_CANAW/21-153 ......................................iqtdfk------NFDS..................................................DSH.E.I...DLFLY..........K...N..........Y.....R..FS..SIDS...I...I...K...E...LTEL...S....TNLNQNLLDLVNDDYHD.FID.......LGK...SIND..G.L.....D....L.....INAI..................VE..DL...K...N...F...E.I..E...L..VN.Y..YK.K.....F.SDLDNRLYQILQNRKFLNNLK.......TCIKLNLIL.HDQITEFD---ncm............................................................................................................................
I1MUP2_SOYBN/25-157 ............................................LWFKPASFLS..................................................PDF.D.S...ESYIS..........E...L..........R.....T..FV..PFDT...L...R...S...E...LNSY...L....SSLNHELIDLINRDYAD.FVN.......LST...KLVD..V.D.....A....V.....VVRM..................RA..PL...V...E...L...R.D..K...I..EQ.F..RG.S.....V.EVSLVAIKNRLRQRSEVASAR.......ETLELLLDA.FHVVSKVEKLI...............................................................................................................................
E7LU90_YEASV/7-176 ..........deldldlpvtaeiskelfateiekyresetngtd---------V..................................................DNF.D.V...DRFLV..........Q..kN..........F.....H..YL..PLDS...L...I...R...D...LSGL...S....QXMVQTLLEQIRSNYDD.YLT.......FSN...TYTD..E.E.....N....Etl.inLEKT..................QS..DL...Q...K...F...M.T..Q...L..DH.L.iKD.D.....I.SNTQEIIKDVLEYLKKLDEIY.......GSLRNHSQL.T----------ealslgkrlskslhem...............................................................................................................
H3DI24_TETNG/15-149 ............................................LCFDKDVFIR..................................................DDF.D.V...DQFVA..........E...C..........R.....K..QV..QLEE...L...R...E...D...LELY...Y....KLLKTAMVELINKDYAD.FVN.......LST...NLVG..M.D.....K....A.....LNQL..................SV..PL...G...Q...L...R.E..E...VlkQS.L..RS.C.....V.SGVIQAIDDQLIKHEDLQHKK.......VCVMRLIQV.VRSVEKIEKIL...............................................................................................................................
#=GC SS_cons ..........XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---------X..................................................XXX.X.X...XXXXX..........X..XX..........X.....X..XX..XXXX...X...X...X...X...XXXX...X....XXXXXXXXXXXXXXXXX.XXX.......XXX...XXXX..X.X.....X....XXX.XXXX-H..................HH..HH...H...H...H...H.H..H...H..HH.H.HHH.S.....-.STTHHHHHHHHHHHHHHHHHH.......HT-SSSSHH.H----------HHHHHHHHHHHHHHHH...............................................................................................................
#=GC seq_cons ...............................................tpttFht..................................................ssF.D.s...-pFls..........p...s..........c.....+..ts..sL-s...L...+...s...-...Lcth...h....phLpspll-LINcDYsD.Fls.......LSs...sLsG..h.-.....c....t.....lppl..................ps..sL...t...p...h...+.c..c...l..ts.l..+s.p.....l.ppthptlpptlpcpcplcppc.......thlptllpl.hcplpclEph................................................................................................................................
//
