GenomeNet

Database: Pfam
Entry: CTK3_C
LinkDB: CTK3_C
Original site: CTK3_C 
#=GF ID   CTK3_C
#=GF AC   PF12350.4
#=GF DE   CTD kinase subunit gamma CTK3 C-terminus
#=GF AU   Wood V, Coggill P
#=GF SE   Pfam-B_12814 (release 23.0)
#=GF GA   25.00 25.00;
#=GF TC   30.10 26.90;
#=GF NC   19.30 18.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   11118453
#=GF RT   Activation of the cyclin-dependent kinase CTDK-I requires the
#=GF RT   heterodimerization of two unstable subunits.
#=GF RA   Hautbergue G, Goguel V;
#=GF RL   J Biol Chem. 2001;276:8005-8013.
#=GF RN   [2]
#=GF RM   16721054
#=GF RT   Bur1/Bur2 and the Ctk complex in yeast: the split personality of
#=GF RT   mammalian P-TEFb.
#=GF RA   Wood A, Shilatifard A;
#=GF RL   Cell Cycle. 2006;5:1066-1068.
#=GF DR   INTERPRO; IPR024637;
#=GF CC   The C-terminal domain kinase (CTDK-1), is a three-subunit
#=GF CC   complex comprised of Ctk1, Ctk2, and Ctk3, that plays a key role
#=GF CC   in regulation of transcription and translation and in
#=GF CC   coordinating these two processes. Both Ctk2 and Ctk3 are
#=GF CC   regulated at the level of protein turnover, and are unstable
#=GF CC   proteins processed through a ubiquitin-proteasome pathway. Their
#=GF CC   physical interaction is required to protect both subunits from
#=GF CC   degradation, and both Ctk2 and Ctk3 are required for Ctk1 CTD
#=GF CC   kinase activation [1]. The mammalian P-TEFb is mirrored by the
#=GF CC   combined complexes in yeast of the CTDK1 and the Bur1/2 [2]. It
#=GF CC   is not clear what independent function this C-terminal domain
#=GF CC   has.
#=GF SQ   282
#=GS B6QK65_PENMQ/170-232      AC B6QK65.1
#=GS W7M9B1_GIBM7/177-239      AC W7M9B1.1
#=GS F8PTJ2_SERL3/180-268      AC F8PTJ2.1
#=GS M2SKM8_COCH5/172-234      AC M2SKM8.1
#=GS A6R2P3_AJECN/178-240      AC A6R2P3.1
#=GS Q2H6I6_CHAGB/124-185      AC Q2H6I6.1
#=GS T5CAD8_AJEDE/178-240      AC T5CAD8.1
#=GS T5AKP1_OPHSC/177-239      AC T5AKP1.1
#=GS A0A022ZDN1_TRIRU/173-235  AC A0A022ZDN1.1
#=GS W6Y805_COCCA/172-234      AC W6Y805.1
#=GS B3LLE7_YEAS1/223-290      AC B3LLE7.1
#=GS S3D1R8_GLAL2/177-241      AC S3D1R8.1
#=GS L7JNS6_MAGOP/178-241      AC L7JNS6.1
#=GS B0D9N2_LACBS/210-286      AC B0D9N2.1
#=GS K0KJG3_WICCF/197-260      AC K0KJG3.1
#=GS M3D671_SPHMS/173-241      AC M3D671.1
#=GS R9AIQ3_WALI9/159-258      AC R9AIQ3.1
#=GS W9KSK1_FUSOX/178-240      AC W9KSK1.1
#=GS E7QIS3_YEASZ/223-290      AC E7QIS3.1
#=GS K9F8J0_PEND2/1041-1103    AC K9F8J0.1
#=GS W7I6Q2_9PEZI/260-338      AC W7I6Q2.1
#=GS J4UPA1_BEAB2/177-239      AC J4UPA1.1
#=GS K1VDL5_TRIAC/185-255      AC K1VDL5.1
#=GS F0UJU6_AJEC8/178-240      AC F0UJU6.1
#=GS M4G5V3_MAGP6/180-242      AC M4G5V3.1
#=GS F0XAN8_GROCL/238-300      AC F0XAN8.1
#=GS G0VAZ5_NAUCC/227-295      AC G0VAZ5.1
#=GS R1GDS1_BOTPV/170-232      AC R1GDS1.1
#=GS A3LWA0_PICST/221-290      AC A3LWA0.2
#=GS U9T537_RHIID/156-218      AC U9T537.1
#=GS E3L3V5_PUCGT/196-277      AC E3L3V5.1
#=GS M1WFN1_CLAP2/176-238      AC M1WFN1.1
#=GS C5JSH2_AJEDS/178-240      AC C5JSH2.1
#=GS A0A028JHG3_TRIRU/173-235  AC A0A028JHG3.1
#=GS F2T3F1_AJEDA/178-240      AC F2T3F1.1
#=GS B2AXB6_PODAN/208-270      AC B2AXB6.1
#=GS A0A059JUT5_TRIRU/173-235  AC A0A059JUT5.1
#=GS M3B532_MYCFI/193-260      AC M3B532.1
#=GS Q5AZG8_EMENI/175-237      AC Q5AZG8.1
#=GS U5GYE5_USTV1/151-272      AC U5GYE5.1
#=GS J8TX76_SACK1/223-290      AC J8TX76.1
#=GS Q4X0V8_ASPFU/174-236      AC Q4X0V8.1
#=GS S7Q763_GLOTA/166-253      AC S7Q763.1
#=GS X0D2Z6_FUSOX/178-240      AC X0D2Z6.1
#=GS E4UMM0_ARTGP/173-235      AC E4UMM0.1
#=GS Q75E03_ASHGO/242-305      AC Q75E03.1
#=GS C5E0M7_ZYGRC/203-268      AC C5E0M7.1
#=GS G2R8Z4_THITE/188-249      AC G2R8Z4.1
#=GS G3ALU7_SPAPN/218-287      AC G3ALU7.1
#=GS S2J881_MUCC1/156-219      AC S2J881.1
#=GS S8AQL7_PENO1/176-238      AC S8AQL7.1
#=GS U7PLA1_SPOS1/230-292      AC U7PLA1.1
#=GS C1GIQ9_PARBD/177-239      AC C1GIQ9.1
#=GS J6EVF3_TRIAS/185-255      AC J6EVF3.1
#=GS M2R3X4_CERS8/153-227      AC M2R3X4.1
#=GS X0MG11_FUSOX/178-240      AC X0MG11.1
#=GS W9Y9K1_9EURO/188-250      AC W9Y9K1.1
#=GS J9MH05_FUSO4/178-240      AC J9MH05.1
#=GS X0K628_FUSOX/178-240      AC X0K628.1
#=GS L2FZI8_COLGN/173-235      AC L2FZI8.1
#=GS G2QDU9_THIHA/183-244      AC G2QDU9.1
#=GS E7KSA6_YEASL/223-290      AC E7KSA6.1
#=GS B9WCX2_CANDC/212-282      AC B9WCX2.1
#=GS CTK3_YEAST/223-290        AC P46963.2
#=GS C4YKX2_CANAW/212-282      AC C4YKX2.1
#=GS E9F120_METAR/176-238      AC E9F120.1
#=GS S6E349_ZYGB2/201-266      AC S6E349.1
#=GS K5W3M7_PHACS/169-257      AC K5W3M7.1
#=GS C0NDA5_AJECG/178-240      AC C0NDA5.1
#=GS A0A023ZE53_YEASX/223-290  AC A0A023ZE53.1
#=GS A7TIV8_VANPO/236-300      AC A7TIV8.1
#=GS W0VCS0_ZYGBA/201-266      AC W0VCS0.1
#=GS W7M9Q9_GIBM7/178-240      AC W7M9Q9.1
#=GS N4WZN6_COCH4/172-234      AC N4WZN6.1
#=GS I8IHM2_ASPO3/170-232      AC I8IHM2.1
#=GS T0JKX4_COLGC/176-238      AC T0JKX4.1
#=GS H1UZN1_COLHI/175-237      AC H1UZN1.1
#=GS C7YNK1_NECH7/177-239      AC C7YNK1.1
#=GS C4R1L6_PICPG/194-259      AC C4R1L6.1
#=GS G8JSB3_ERECY/226-289      AC G8JSB3.1
#=GS A0A022V1Q8_TRIRU/173-235  AC A0A022V1Q8.1
#=GS G8YD60_PICSO/234-303      AC G8YD60.1
#=GS D8PNY1_SCHCM/175-260      AC D8PNY1.1
#=GS B8MLI2_TALSN/170-232      AC B8MLI2.1
#=GS N1RC02_FUSC4/177-239      AC N1RC02.1
#=GS W9IZZ0_FUSOX/178-240      AC W9IZZ0.1
#=GS E3RGG4_PYRTT/173-235      AC E3RGG4.1
#=GS F2QS45_PICP7/194-259      AC F2QS45.1
#=GS A0A024XJI0_YEASX/223-290  AC A0A024XJI0.1
#=GS A5DDQ1_PICGU/225-294      AC A5DDQ1.2
#=GS A0A015KX64_9GLOM/1-55     AC A0A015KX64.1
#=GS G4N7S4_MAGO7/180-243      AC G4N7S4.1
#=GS A0A016PP28_GIBZA/176-238  AC A0A016PP28.1
#=GS A0A024XYK8_YEASX/223-290  AC A0A024XYK8.1
#=GS R7SAN8_TREMS/158-225      AC R7SAN8.1
#=GS R7SME3_DICSQ/168-254      AC R7SME3.1
#=GS G9P4Q4_HYPAI/184-246      AC G9P4Q4.1
#=GS K2S301_MACPH/170-232      AC K2S301.1
#=GS W9YSG3_9EURO/187-249      AC W9YSG3.1
#=GS G1X440_ARTOA/233-311      AC G1X440.1
#=GS G8ZNJ7_TORDC/217-282      AC G8ZNJ7.1
#=GS W9MYJ2_FUSOX/178-240      AC W9MYJ2.1
#=GS A0A022TH01_TRIRU/173-235  AC A0A022TH01.1
#=GS Q6FP45_CANGA/277-343      AC Q6FP45.1
#=GS A6ZLV2_YEAS7/223-290      AC A6ZLV2.1
#=GS A0A059J137_9EURO/173-235  AC A0A059J137.1
#=GS E7LYJ3_YEASV/223-290      AC E7LYJ3.1
#=GS H2AMW6_KAZAF/179-251      AC H2AMW6.1
#=GS D4CZT4_TRIVH/173-235      AC D4CZT4.1
#=GS R8BUS7_TOGMI/178-241      AC R8BUS7.1
#=GS J3P3U7_GAGT3/180-243      AC J3P3U7.1
#=GS B5RUA8_DEBHA/233-302      AC B5RUA8.1
#=GS M7U356_BOTF1/221-284      AC M7U356.1
#=GS I2GYG1_TETBL/196-282      AC I2GYG1.1
#=GS K3VV79_FUSPC/176-238      AC K3VV79.1
#=GS A0A022UHM2_9EURO/173-235  AC A0A022UHM2.1
#=GS Q0CYT5_ASPTN/175-237      AC Q0CYT5.1
#=GS J3QAW8_PUCT1/203-283      AC J3QAW8.1
#=GS A8N4W9_COPC7/200-302      AC A8N4W9.2
#=GS G2WJU4_YEASK/223-290      AC G2WJU4.1
#=GS R4X7H9_TAPDE/154-217      AC R4X7H9.1
#=GS D4AWM3_ARTBC/119-181      AC D4AWM3.1
#=GS N4TYP7_FUSC1/177-239      AC N4TYP7.1
#=GS E7KG57_YEASA/223-286      AC E7KG57.1
#=GS R0JQS6_SETT2/171-233      AC R0JQS6.1
#=GS W9WHS4_9EURO/194-256      AC W9WHS4.1
#=GS X0GCV7_FUSOX/177-239      AC X0GCV7.1
#=GS B5VP19_YEAS6/223-290      AC B5VP19.1
#=GS W6QL02_PENRO/169-231      AC W6QL02.1
#=GS C8ZE91_YEAS8/223-290      AC C8ZE91.1
#=GS F2S8P6_TRIT1/173-235      AC F2S8P6.1
#=GS F4NU91_BATDJ/168-239      AC F4NU91.1
#=GS G4UN83_NEUT9/231-291      AC G4UN83.1
#=GS W3WPH1_9PEZI/479-541      AC W3WPH1.1
#=GS W9PW16_FUSOX/177-239      AC W9PW16.1
#=GS W9PWC3_FUSOX/178-240      AC W9PWC3.1
#=GS C5PBY2_COCP7/168-230      AC C5PBY2.1
#=GS W4JNU8_9HOMO/169-254      AC W4JNU8.1
#=GS X0D406_FUSOX/177-239      AC X0D406.1
#=GS X0IN32_FUSOX/178-240      AC X0IN32.1
#=GS A1C6P7_ASPCL/174-236      AC A1C6P7.1
#=GS M5FPB2_DACSP/168-250      AC M5FPB2.1
#=GS L7IM82_MAGOY/178-241      AC L7IM82.1
#=GS C5GDX3_AJEDR/178-240      AC C5GDX3.1
#=GS E9DSP1_METAQ/176-238      AC E9DSP1.1
#=GS H0EGK1_GLAL7/107-171      AC H0EGK1.1
#=GS L8G7A6_PSED2/178-245      AC L8G7A6.1
#=GS F8ML44_NEUT8/231-291      AC F8ML44.1
#=GS G3BCQ9_CANTC/226-295      AC G3BCQ9.1
#=GS G3J5K0_CORMM/260-322      AC G3J5K0.1
#=GS C6HK49_AJECH/178-240      AC C6HK49.1
#=GS F2Q3P9_TRIEC/173-235      AC F2Q3P9.1
#=GS R7YR32_CONA1/180-242      AC R7YR32.1
#=GS Q5A5P9_CANAL/212-282      AC Q5A5P9.1
#=GS U1GT24_ENDPU/228-290      AC U1GT24.1
#=GS X0K5R7_FUSOX/177-239      AC X0K5R7.1
#=GS L0P9N6_PNEJ8/155-219      AC L0P9N6.1
#=GS A5DY84_LODEL/219-290      AC A5DY84.1
#=GS Q4PHG1_USTMA/158-233      AC Q4PHG1.1
#=GS S3C5P3_OPHP1/216-278      AC S3C5P3.1
#=GS A0A022XM48_TRISD/173-235  AC A0A022XM48.1
#=GS M7S5V5_EUTLA/174-235      AC M7S5V5.1
#=GS S9PSI1_SCHOY/153-214      AC S9PSI1.1
#=GS J8LK89_SACAR/224-290      AC J8LK89.1
#=GS X0IMK9_FUSOX/177-239      AC X0IMK9.1
#=GS B6HHC9_PENCW/168-230      AC B6HHC9.1
#=GS H0GLN3_SACCK/223-290      AC H0GLN3.1
#=GS W9CJS4_9HELO/218-281      AC W9CJS4.1
#=GS E5A0V7_LEPMJ/166-228      AC E5A0V7.1
#=GS W0VSW7_ZYGBA/201-266      AC W0VSW7.1
#=GS F7WB08_SORMK/233-285      AC F7WB08.1
#=GS Q0U2X2_PHANO/162-224      AC Q0U2X2.1
#=GS C4JXE8_UNCRE/122-184      AC C4JXE8.1
#=GS G8YFL3_PICSO/234-303      AC G8YFL3.1
#=GS W9NBJ7_FUSOX/177-239      AC W9NBJ7.1
#=GS W6MLP6_9ASCO/240-306      AC W6MLP6.1
#=GS X0ACX7_FUSOX/177-239      AC X0ACX7.1
#=GS G8BQW3_TETPH/243-308      AC G8BQW3.1
#=GS R9X8U5_ASHAC/242-305      AC R9X8U5.1
#=GS C1GNM2_PARBA/177-239      AC C1GNM2.1
#=GS A0A022WS74_TRIRU/173-235  AC A0A022WS74.1
#=GS I1RSW9_GIBZE/176-238      AC I1RSW9.1
#=GS V2YX71_MONRO/173-261      AC V2YX71.1
#=GS B6JZW0_SCHJY/156-217      AC B6JZW0.1
#=GS S8BSK5_DACHA/235-314      AC S8BSK5.1
#=GS J7S1C5_KAZNA/201-266      AC J7S1C5.1
#=GS G2X794_VERDV/185-246      AC G2X794.1
#=GS M7XLK5_RHOT1/166-300      AC M7XLK5.1
#=GS Q55NS7_CRYNB/159-289      AC Q55NS7.1
#=GS F4RIT2_MELLP/199-246      AC F4RIT2.1
#=GS G7DWG1_MIXOS/155-264      AC G7DWG1.1
#=GS A0A010S539_9PEZI/177-239  AC A0A010S539.1
#=GS U4L0F8_PYROM/177-242      AC U4L0F8.1
#=GS K1WW13_MARBU/157-220      AC K1WW13.1
#=GS S8EM14_FOMPI/173-262      AC S8EM14.1
#=GS W1QF61_OGAPD/216-279      AC W1QF61.1
#=GS X8J5G1_9HOMO/383-543      AC X8J5G1.1
#=GS T2BPM0_CRYNH/159-291      AC T2BPM0.1
#=GS B8NGF7_ASPFN/170-232      AC B8NGF7.1
#=GS S0E0E8_GIBF5/178-240      AC S0E0E8.1
#=GS CTK3_SCHPO/153-214        AC Q9USJ8.1
#=GS G0WAS8_NAUDC/324-400      AC G0WAS8.1
#=GS E7NL69_YEASO/223-290      AC E7NL69.1
#=GS K9I620_AGABB/173-263      AC K9I620.1
#=GS W0T469_KLUMA/253-316      AC W0T469.1
#=GS N4USW3_COLOR/176-238      AC N4USW3.1
#=GS F8NQE9_SERL9/180-268      AC F8NQE9.1
#=GS E9D837_COCPS/169-231      AC E9D837.1
#=GS F2SLG6_TRIRC/173-235      AC F2SLG6.1
#=GS Q7RYU9_NEUCR/237-297      AC Q7RYU9.1
#=GS G0SHE8_CHATD/186-248      AC G0SHE8.1
#=GS J3KFY1_COCIM/169-231      AC J3KFY1.1
#=GS V5FCA5_BYSSN/174-236      AC V5FCA5.1
#=GS G3Y2S4_ASPNA/180-242      AC G3Y2S4.1
#=GS X0ABL8_FUSOX/178-240      AC X0ABL8.1
#=GS C5FNA0_ARTOC/170-232      AC C5FNA0.1
#=GS G0RD12_HYPJQ/175-237      AC G0RD12.1
#=GS W9ITR4_FUSOX/177-239      AC W9ITR4.1
#=GS X0MFV1_FUSOX/177-239      AC X0MFV1.1
#=GS W7DZ26_COCVI/172-234      AC W7DZ26.1
#=GS A0A022YHJ3_TRIRU/173-235  AC A0A022YHJ3.1
#=GS Q2UEY0_ASPOR/170-232      AC Q2UEY0.1
#=GS W7PBE1_YEASX/223-290      AC W7PBE1.1
#=GS A0A023A8Z7_TRIRU/173-235  AC A0A023A8Z7.1
#=GS M3HPL3_CANMX/213-283      AC M3HPL3.1
#=GS S9X0S8_SCHCR/153-214      AC S9X0S8.1
#=GS M5BZ67_THACB/105-265      AC M5BZ67.1
#=GS I4YBM6_WALSC/154-250      AC I4YBM6.1
#=GS A1DHB8_NEOFI/175-237      AC A1DHB8.1
#=GS B2WIA8_PYRTR/173-235      AC B2WIA8.1
#=GS M2SML1_COCSN/172-234      AC M2SML1.1
#=GS E3QCM0_COLGM/175-237      AC E3QCM0.1
#=GS G2Y0N2_BOTF4/221-284      AC G2Y0N2.1
#=GS R9P245_PSEHS/159-261      AC R9P245.1
#=GS B8P6Q8_POSPM/169-261      AC B8P6Q8.1
#=GS M2NIV7_BAUCO/189-254      AC M2NIV7.1
#=GS M9LVD5_PSEA3/555-657      AC M9LVD5.1
#=GS F9X7G0_MYCGM/167-237      AC F9X7G0.1
#=GS I2G4V8_USTH4/161-262      AC I2G4V8.1
#=GS C4Y6A2_CLAL4/232-301      AC C4Y6A2.1
#=GS V5GW19_PSEBG/158-258      AC V5GW19.1
#=GS W9XQC7_9EURO/195-257      AC W9XQC7.1
#=GS W3VPU4_9BASI/554-656      AC W3VPU4.1
#=GS A0A017SL42_9EURO/171-233  AC A0A017SL42.1
#=GS W9KMZ2_FUSOX/177-239      AC W9KMZ2.1
#=GS C9SUW7_VERA1/185-246      AC C9SUW7.1
#=GS N1JNF4_BLUG1/167-231      AC N1JNF4.1
#=GS G8BK06_CANPC/206-275      AC G8BK06.1
#=GS W6ZDN1_COCMI/172-234      AC W6ZDN1.1
#=GS E6ZKK9_SPORE/159-254      AC E6ZKK9.1
#=GS H8X4C9_CANO9/206-275      AC H8X4C9.1
#=GS Q6CSE1_KLULA/278-340      AC Q6CSE1.1
#=GS W2RSG6_9EURO/187-249      AC W2RSG6.1
#=GS M9MWD3_ASHG1/242-305      AC M9MWD3.1
#=GS H6QUJ2_PUCGT/195-275      AC H6QUJ2.1
#=GS D5GJJ1_TUBMM/177-242      AC D5GJJ1.1
#=GS J9VS12_CRYNH/160-292      AC J9VS12.2
#=GS B0XSN6_ASPFC/174-236      AC B0XSN6.1
#=GS F9FB94_FUSOF/177-239      AC F9FB94.1
#=GS G9N9Q9_HYPVG/175-237      AC G9N9Q9.1
#=GS N1PPQ6_MYCP1/179-246      AC N1PPQ6.1
#=GS C5DDV0_LACTC/233-296      AC C5DDV0.1
#=GS K9FSK0_PEND1/1041-1103    AC K9FSK0.1
#=GS J4GH12_FIBRA/1023-1112    AC J4GH12.1
#=GS V9DMG0_9EURO/193-255      AC V9DMG0.1
#=GS U5GYE4_USTV1/158-279      AC U5GYE4.1
#=GS C7GV94_YEAS2/223-290      AC C7GV94.1
#=GS I1BWB2_RHIO9/154-217      AC I1BWB2.1
#=GS N1NYQ0_YEASC/223-290      AC N1NYQ0.1
#=GS W7R6I4_YEASX/223-290      AC W7R6I4.1
#=GS A2QCN2_ASPNC/180-242      AC A2QCN2.1
#=GS H6C3G8_EXODN/213-275      AC H6C3G8.1
#=GS G7X5B6_ASPKW/180-242      AC G7X5B6.1
#=GS K5WY59_AGABU/173-263      AC K5WY59.1
#=GS L8WKA7_THACA/244-394      AC L8WKA7.1
#=GS A0A024SLR3_HYPJE/175-237  AC A0A024SLR3.1
#=GS C0SBT8_PARBP/177-239      AC C0SBT8.1
#=GS A0A022VWW1_TRIRU/173-235  AC A0A022VWW1.1
#=GS E3KJD5_PUCGT/196-276      AC E3KJD5.1
#=GS X0GNN6_FUSOX/178-240      AC X0GNN6.1
#=GS G4TB04_PIRID/183-298      AC G4TB04.1
#=GS Q6C0W5_YARLI/181-242      AC Q6C0W5.1
B6QK65_PENMQ/170-232                 ......................DKRQIEQRIEEDRERNKRLRESMWTVSGDN.....---..........---...............................................................................................KGEF.QQCWD..EV.S...DIGED..DYLGAEEEFGERRQMV....................................................
W7M9B1_GIBM7/177-239                 ......................DKRQIEQRIEEDRERHKRERESIWAVPKVE.....---..........---...............................................................................................NAEM.DRLWE..ET.S...DFGED..DDRLLTEELDDFHK--em..................................................
F8PTJ2_SERL3/180-268                 ......................SRGEIFKRIEEDRERHKRLRERRWVQPVSHtpfshT--..........--Qhlaaflpltd...........................................................................dqdgaeeltlDIEF.ENEWD..AT.S...DWNED..DVEAATEESELCF---st..................................................
M2SKM8_COCH5/172-234                 ......................DKRQIEQRIEEDRERHKRLRESIWAVPGDG.....---..........---...............................................................................................FEEF.EKLWE..EA.S...DVNED..DYVTAREDAEERRKV-i...................................................
A6R2P3_AJECN/178-240                 ......................DKRQIEQRIEEDRERNKRLRESMWAVPGND.....---..........---...............................................................................................ADEF.DKMWD..EV.S...DLGED..DYLAAEEEAMERKRI-a...................................................
Q2H6I6_CHAGB/124-185                 ......................DKKQTEQRIEEDRERHKRQRENIWAVPPGE.....---..........---...............................................................................................DAEM.EKLWE..ET.S...DLGED..DHRMGEEEWAEWE---ae..................................................
T5CAD8_AJEDE/178-240                 ......................DKRQIEQRIEEDRERNKRLRESMWAVPGND.....---..........---...............................................................................................ADEL.DKMWD..EV.S...DLGED..DYLAAEEEAMERKRI-a...................................................
T5AKP1_OPHSC/177-239                 ......................DKRQIEQRIEEDRERHKRARESIWATPKGE.....---..........---...............................................................................................DAEM.NKLWE..ET.S...DFGED..DDRLLTEEAQDFS---kem.................................................
A0A022ZDN1_TRIRU/173-235             ......................DRKQIEQRVEEDRERNKRLRENMWAVPPHD.....---..........---...............................................................................................MKEF.EKMWD..EV.S...DVGDD..DYLQAAEEAEERRRT-a...................................................
W6Y805_COCCA/172-234                 ......................DKRQIEQRIEEDRERHKRLRESIWAVPGDG.....---..........---...............................................................................................YEEF.EKLWE..EA.S...DVNED..DYVTAREDAEERRKV-i...................................................
B3LLE7_YEAS1/223-290                 ...................nan---ILLHRMEADRELHKRSKETSWHIERPS.....-ND..........ILD...............................................................................................ESEF.KSLWT..HF.E...TTDSG..FDKDDYKNIKALNDI-a...................................................
S3D1R8_GLAL2/177-241                 ......................DRKQIEQRIEEDRERHKRLRENIWAVPNTG.....---..........-VE...............................................................................................DEEF.AKMWE..ET.S...DVGED..DFILYAEEAAERREA-a...................................................
L7JNS6_MAGOP/178-241                 .....................e-KKQIEQRIEEDRERHKRLREEIWAIPNEG.....---..........--Y...............................................................................................EAEM.DKMWE..ET.S...DLGED..DHIMGEEEKEEREE--wl..................................................
B0D9N2_LACBS/210-286                 ......................SRSDVFKRIEEDRERHKRLRERRWVQPVFKa..qgQPG..........LVSfl..........................................................................................ddeDVEF.ENEWE..TT.S...DWNED..DDDAVAEEVRMCFSA-e...................................................
K0KJG3_WICCF/197-260                 .....................t-KDQILMRIEADRERHKRFKEVNWIVNRPS.....--G..........KVE...............................................................................................MKEF.EKIWN..QY.G...ELAEG..DYQDLKE---------lndiak..............................................
M3D671_SPHMS/173-241                 ......................DKRQIEQRIEEDRERHKRARENIWAVPQQR.....GGD..........MAT...............................................................................................DKEF.ENVWD..SG.S...DVDSD..DYRMAEEEADERRR--hl..................................................
R9AIQ3_WALI9/159-258                 .....................p-DKEILRRFEEDRERHKRLKEEMWVLPISTl..srDDA..........MNYhtpspghskhhnlh...................................................................ktnlltltadnaplNTEF.DHAWE..DT.S...DYNED..DVEEMLDDMNNLHSA-q...................................................
W9KSK1_FUSOX/178-240                 ......................DKRQIEQRIEEDRERHKRERESIWAVPKAE.....---..........---...............................................................................................NAEM.DRLWE..ET.S...DFGED..DDRLLTEELDDFQK--em..................................................
E7QIS3_YEASZ/223-290                 ...................nan---ILLHRMEADRELHKRSKETSWYIERPS.....-ND..........ILD...............................................................................................ESEF.KSLWT..HF.X...TTDSG..FDKDDYKNIKALNDI-a...................................................
K9F8J0_PEND2/1041-1103               ......................DKRQIEQRIEEDRERNKRQRESMWAMTGND.....---..........---...............................................................................................LDEY.NQMWE..EL.S...PIGED..DFIRSREEALERAEC-v...................................................
W7I6Q2_9PEZI/260-338                 .....................p-KQVIEERMEEDRERHKRLRETIWAIYPAR.....DDA..........VLDrsleg.....................................................................................leafvGPEF.EMFWS..DA.Te.aEVNED..DMELMAEEAE------lkie................................................
J4UPA1_BEAB2/177-239                 ......................DKRQVEQRLEEDRERHKRERESIWAIPKGE.....---..........---...............................................................................................GAEM.NKLWD..ET.S...DFGED..DDRLITEENADF----dtem................................................
K1VDL5_TRIAC/185-255                 .....................k-RSDVLLRIEEDRERQKRLREKRWILPIPAp...gSEV..........NPA...............................................................................................DVEF.DLMWD..AL.EvapGLDDD..DRERMRHDL-------aaag................................................
F0UJU6_AJEC8/178-240                 ......................DKRQIEQRIEEDRERNKRLRESMWAVPGND.....---..........---...............................................................................................ADEF.DKMWD..EV.S...DLGED..DYLAAEEEAMERKRI-a...................................................
M4G5V3_MAGP6/180-242                 .....................e-RKQVEQRIEEDRERHKRLREDIWAIPKEG.....---..........--Y...............................................................................................DAEM.EKMWE..ET.S...DLGED..DHIMGEEER-------larlew..............................................
F0XAN8_GROCL/238-300                 ......................DKKQIEERIEEDRERHKRLRENIWAVPGGT.....---..........---...............................................................................................DTEM.WKIWE..ET.S...ELGED..DHVMGEEEQAERSR--nl..................................................
G0VAZ5_NAUCC/227-295                 .....................t--TTILHRMENDRERHKRMKEQRWIIERGNq..lnKKT..........ILD...............................................................................................EQEF.KLLWE..NQ.D...--NNT..LTTDDIKNVKEMNL--ia..................................................
R1GDS1_BOTPV/170-232                 ......................DKRQVEQRIEEDRERHKRLREVIWQVDPEN.....---..........---...............................................................................................DGEF.EKLWE..ES.S...DIGDD..DYIAAEEDAEERKQA-i...................................................
A3LWA0_PICST/221-290                 .....................t-KKNIISRMEDDREAHKRSKETLWLVTRPP.....KSS..........YIT...............................................................................................EDEFlNHYWN..KY.H...ALDVE..EDNAFLDSLDELNQV-v...................................................
U9T537_RHIID/156-218                 ....................ta--AEIKQRMEDDRERAKLLREDSWWVDKSV.....---..........--E...............................................................................................DGEA.LALWE..ET.S...DLDEG..DYIDIITE--------nikqdss.............................................
E3L3V5_PUCGT/196-277                 ......................SKKEILDRIDDDRERHKRLRERIWVLPIPS.....---..........---...............................................................................................----.-----..--.-...-----..----------------iatlspkptanahhpattytyhrsatllhtsllsagtgadrpvgphiesdlt
M1WFN1_CLAP2/176-238                 ......................DKRQIEQRIEEDRERHKRQRESIWAIPRMD.....---..........---...............................................................................................NAEL.NKLWE..ET.S...DFGED..DDRLLTEEANDFEK--em..................................................
C5JSH2_AJEDS/178-240                 ......................DKRQIEQRIEEDRERNKRLRESMWAVPGND.....---..........---...............................................................................................ADEL.DKMWD..EV.S...DLGED..DYLAAEEEAMERKRI-a...................................................
A0A028JHG3_TRIRU/173-235             ......................DRKQIEQRVEEDRERNKRLRENMWAVPPHD.....---..........---...............................................................................................MKEF.EKMWD..EV.S...DVGDD..DYLQAAEEAEERRRT-a...................................................
F2T3F1_AJEDA/178-240                 ......................DKRQIEQRIEEDRERNKRLRESMWAVPGND.....---..........---...............................................................................................ADEL.DKMWD..EV.S...DLGED..DYLAAEEEAMERKRI-a...................................................
B2AXB6_PODAN/208-270                 ......................DRKQVEQRIEEDRERHKRQREGIWAVSPEN.....---..........---...............................................................................................EAEL.RKLWE..ET.S...ELGED..DERMCDEEWEEWEEA-m...................................................
A0A059JUT5_TRIRU/173-235             ......................DRKQIEQRVEEDRERNKRLRENMWAVPPHD.....---..........---...............................................................................................MKEF.EKMWD..EV.S...DVGDD..DYLQAAEEAEERRRT-a...................................................
M3B532_MYCFI/193-260                 ......................DKRQIEQRIEEDRERHKRARENIWAIPQPS.....-AN..........LSH...............................................................................................DAEF.EKLWE..EG.S...DVDSD..DYRMAKEEAEERRK--hl..................................................
Q5AZG8_EMENI/175-237                 ......................DKRQIEQRIEEDRERNKRLRESMWTVRGDD.....---..........---...............................................................................................SDEH.RKFWD..ET.S...DIGED..DFTTAHEELMERNEM-i...................................................
U5GYE5_USTV1/151-272                 ......................SRNDILRRIEDDRERHKRLRERIWVLPIPT.....S-L..........FIIptansnptwsnlssikpspispaspsepps...................................srihktntssstlapstsgaavqrgpevpiDLEF.EQTWA..RL.N...E----..----------------erefaelerndveg......................................
J8TX76_SACK1/223-290                 ...................nan---ILLHRMEADRELHKRSKETSWCVERPS.....-ND..........ILD...............................................................................................ESEF.QTLWT..HF.E...TTDSG..FDKDDYKNIKALNDI-a...................................................
Q4X0V8_ASPFU/174-236                 ......................DKRQIEQRIEEDRERNKRLRESMWTVSGDD.....---..........---...............................................................................................GDEH.GKFWD..EV.S...DIGED..DFLGAQEELMERNQMV....................................................
S7Q763_GLOTA/166-253                 ......................SKNDVFKRIEEDRERHKRLRERRWVQPVTH.....NHA..........QLQgqlasflplt..........................................................................ddadgegeltiDIEF.DNEWE..TT.S...DWNED..DDEAAAEENELC----fp..................................................
X0D2Z6_FUSOX/178-240                 ......................DKRQIEQRIEEDRERHKRERESIWAVPKAE.....---..........---...............................................................................................NAEM.DRLWE..ET.S...DFGED..DDRLLTEELDDFQK--em..................................................
E4UMM0_ARTGP/173-235                 ......................DRKQIEQRVEEDRERNKRLRENMWAVPPHD.....---..........---...............................................................................................MKEF.EKMWD..EV.S...DVGED..DYLQAAEEAEERRRT-a...................................................
Q75E03_ASHGO/242-305                 .....................s-ASTILHRMESDRERHKKSKEHLWFTDRDS.....--S..........MLE...............................................................................................LAEF.DALWQ..QH.R...---KG..MTRDDYQDVKQLQRI-a...................................................
C5E0M7_ZYGRC/203-268                 ......................STQTIIHRMESDREKHKRLKENIWVLPRPH.....-AS..........ILN...............................................................................................EFEF.RTLWE..ST.P...Q--EG..LTKGDYRNMSDMNRI-a...................................................
G2R8Z4_THITE/188-249                 ......................DKKQIEQRMEEDRERHKRQRENIWAVPPGE.....---..........---...............................................................................................DAEM.EKLWE..ET.S...DLGED..DHRMGEEELAEWR---ae..................................................
G3ALU7_SPAPN/218-287                 ......................SKRQILSRMEDDREAHKRSKENLWVVNRDK.....NSS..........FIT...............................................................................................EQEFlDNYWN..KY.H...QLNKS..DHEEFLNSLSGLNKL-v...................................................
S2J881_MUCC1/156-219                 ......................SKEDILRRMEEDRERHKRLREEIWIRPAEE.....S--..........--Q...............................................................................................DAEF.EEFWN..TT.E...TLDPE..SDYE------------vmmvqnmlrlp.........................................
S8AQL7_PENO1/176-238                 ......................DKRQIEQRIEEDRERNKRLRESMWAVGGGD.....---..........---...............................................................................................QDEW.HKFND..DL.S...DIDDD..DLGNTEEEMSERDHA-a...................................................
U7PLA1_SPOS1/230-292                 ......................DKRQIEERIEEDRERHKRLRESIWAVPKGR.....---..........---...............................................................................................DAEM.WRLWE..ET.S...DLGED..DHLMGEEEEAERERA-v...................................................
C1GIQ9_PARBD/177-239                 ......................DKRQIEQRIEEDRERNKRLRESMWAVPGND.....---..........---...............................................................................................TDEF.DKMWD..EV.S...DLGED..DYLAAEEEAMERKRI-a...................................................
J6EVF3_TRIAS/185-255                 .....................k-RSDVLLRIEEDRERQKRLREKRWILPIPAp...gSEV..........NPA...............................................................................................DVEF.DLMWD..AL.EvapGLDDD..DRERMRHDL-------aaag................................................
M2R3X4_CERS8/153-227                 rpssaalprtepvshnpqtnma------------------------------.....---..........--Tqlaaflpltd...........................................................................dgdgeeeltlDIEF.ENDWE..TT.S...DWNED..DDDAVVEENDLC----fpa.................................................
X0MG11_FUSOX/178-240                 ......................DKRQIEQRIEEDRERHKRERESIWAVPKAE.....---..........---...............................................................................................NAEM.DRLWE..ET.S...DFGED..DDRLLTEELDDFQK--em..................................................
W9Y9K1_9EURO/188-250                 ......................DKRAIEQRIEEDRERNKRLRESVWAVTGDD.....---..........---...............................................................................................DQEL.DKMWE..EG.S...YLGED..ERVIAGEEAEERL---qft.................................................
J9MH05_FUSO4/178-240                 ......................DKRQIEQRIEEDRERHKRERESIWAVPKAE.....---..........---...............................................................................................NAEM.DRLWE..ET.S...DFGED..DDRLLTEELDDFQK--em..................................................
X0K628_FUSOX/178-240                 ......................DKRQIEQRIEEDRERHKRERESIWAVPKAE.....---..........---...............................................................................................NAEM.DRLWE..ET.S...DFGED..DDRLLTEELDDFQK--em..................................................
L2FZI8_COLGN/173-235                 .....................e-KRQIEQRIEEDRERHKRLRESIWAIPSHD.....---..........---...............................................................................................NAET.DKIWE..ET.S...DMGDD..DHILGQEEFTEWRQ--sm..................................................
G2QDU9_THIHA/183-244                 ......................DKKQIEQRIEEDRERHKRQRENIWAVPPGK.....---..........---...............................................................................................NAEM.EKLWE..ET.S...DLGED..DHRMGEEEWAEWK---ae..................................................
E7KSA6_YEASL/223-290                 ...................nan---ILLHRMEADRELHKRSKETSWYIERPS.....-ND..........ILD...............................................................................................ESEF.KSLWT..HF.E...TTDSG..FDKDDYKNIKALNDI-a...................................................
B9WCX2_CANDC/212-282                 ......................SKRHILVRMEDDREAHKRSKENFWVVNRDK....dKGN..........YIT...............................................................................................EDEFvDHYWN..KF.Q...PLTDQ..ENKEFLNSLQELNGI-v...................................................
CTK3_YEAST/223-290                   ...................nan---ILLHRMEADRELHKRSKETSWYIERPS.....-ND..........ILD...............................................................................................ESEF.KSLWT..HF.E...TTDSG..FDKDDYKNIKALNDI-a...................................................
C4YKX2_CANAW/212-282                 ......................SKRQILVRMEDDREAHKRSKENFWVVNRDK....eKGN..........HIT...............................................................................................EDEFvSHYWN..KF.Q...PLNDQ..ENKEFLNSLQELNVI-v...................................................
E9F120_METAR/176-238                 ......................DKRQVEQRIEEDRERHKRQRESIWAIPKTE.....---..........---...............................................................................................DAEM.NKLWE..ET.S...DFGED..DDRLLSEEAEDCV---kem.................................................
S6E349_ZYGB2/201-266                 ....................sp--QTVIHRMENDREKHKRLKENIWVLPRPN.....-AN..........ILD...............................................................................................PHEF.DLLWN..AT.P...S--EG..LTKGDYRHINEMRKI-a...................................................
K5W3M7_PHACS/169-257                 .....................p-KQEIFKRIEEDRERHKRLRERRWVQPVAH....nPHS..........HLPpqlasflplt..........................................................................ddgdgeeeltlDIEF.ENDWE..TT.S...DWNED..DDEAAQEENALC----fp..................................................
C0NDA5_AJECG/178-240                 ......................DKRQIEQRIEEDRERNKRLRESMWAVPGND.....---..........---...............................................................................................ADEF.DKMWD..EV.S...DLGED..DYLAAEEEAMERKRI-a...................................................
A0A023ZE53_YEASX/223-290             ...................nan---ILLHRMEADRELHKRSKETSWYIERPS.....-ND..........ILD...............................................................................................ESEF.KSLWT..HF.E...TTDSG..FDKDDYKNIKALNDI-a...................................................
A7TIV8_VANPO/236-300                 .....................s-TQITLHRMESDRERHKRAKEHMWFINKTN.....---..........MLD...............................................................................................ESEF.QNLWN..KI.P...NSLTA..EDLTSIQEIQS-----iakq................................................
W0VCS0_ZYGBA/201-266                 ....................sp--QTVIHRMENDREKHKRLKENIWVLPRPN.....-AN..........ILD...............................................................................................PHEF.DLLWN..AT.P...S--EG..LTKGDYRHINEMRKI-a...................................................
W7M9Q9_GIBM7/178-240                 ......................DKRQIEQRIEEDRERHKRERESIWAVPKVE.....---..........---...............................................................................................NAEM.DRLWE..ET.S...DFGED..DDRLLTEELDDFHK--em..................................................
N4WZN6_COCH4/172-234                 ......................DKRQIEQRIEEDRERHKRLRESIWAVPGDG.....---..........---...............................................................................................FEEF.EKLWE..EA.S...DVNED..DYVTAREDAEERRKV-i...................................................
I8IHM2_ASPO3/170-232                 ......................DKRQIEQRIEEDRERNKRLRESMWTVSGDD.....---..........---...............................................................................................GDEH.GKFWD..ET.S...DIGED..DFLAANEEFIERRQM-v...................................................
T0JKX4_COLGC/176-238                 .....................e-KRQIEQRIEEDRERHKRLRESIWAIPSHD.....---..........---...............................................................................................NAET.DKIWE..ET.S...DMGDD..DHILGQEEFTEWRQ--sm..................................................
H1UZN1_COLHI/175-237                 .....................e-KRQIEQRIEEDRERHKRLRENIWAIGAHD.....---..........---...............................................................................................NAEV.DKIWE..ET.S...DFGDD..DHILAEEEFTEFTQA-m...................................................
C7YNK1_NECH7/177-239                 ......................DKRQIEQRIEEDRERHKRERESIWAIPKVE.....---..........---...............................................................................................NAEM.SKLWE..DT.S...DFGED..DDRLLTEELADFR---kem.................................................
C4R1L6_PICPG/194-259                 ......................SEQQILARMEADRERHKRAKEKLWMVTRES.....--Y..........SLS...............................................................................................FNEF.ENIDD..RF.S...SLQDE..DYKELREL--------krlvnks.............................................
G8JSB3_ERECY/226-289                 ......................SANTILHRMENDRERHKKSKEHLWFTERDY.....--S..........MLE...............................................................................................VSEF.DILWE..QN.R...---KG..MTRDDYQDIKQLHRL-a...................................................
A0A022V1Q8_TRIRU/173-235             ......................DRKQIEQRVEEDRERNKRLRENMWAVPPHD.....---..........---...............................................................................................MKEF.EKMWD..EV.S...DVGDD..DYLQAAEEAEERRRT-a...................................................
G8YD60_PICSO/234-303                 ......................TKKQILMRMEDDRESHKRSKENLWVVNRPK.....DSN..........SLT...............................................................................................EDEFlVYYWN..KF.G...NVTEE..EDKSFRESLNDLNAM-v...................................................
D8PNY1_SCHCM/175-260                 ......................SRNEIFKRIEEDRERHKRLRERRWVQPVSY.....-DA..........VPTlatflpltd............................................................................eadgerelplDVEF.ENAWE..TT.S...DWNED..DEEAMREENELC----fpk.................................................
B8MLI2_TALSN/170-232                 ......................DKRQIEQRIEEDRERNKRLRESMWTVSGNN.....---..........---...............................................................................................KGEF.QQCWD..DV.S...DIGDD..DFLGAEEECAERKQMV....................................................
N1RC02_FUSC4/177-239                 ......................DKRQIEQRIEEDRERHKRERESIWAVPKAE.....---..........---...............................................................................................NAEM.DRLWE..ET.S...DFGED..DDRLLTEELDDFQK--em..................................................
W9IZZ0_FUSOX/178-240                 ......................DKRQIEQRIEEDRERHKRERESIWAVPKAE.....---..........---...............................................................................................NAEM.DRLWE..ET.S...DFGED..DDRLLTEELDDFQK--em..................................................
E3RGG4_PYRTT/173-235                 .....................g-KREIEQRIEEDRERHKRLRESIWAVNGDG.....---..........---...............................................................................................YEEL.ERLWE..EA.S...DIGED..DYVTAREDAEERRRV-i...................................................
F2QS45_PICP7/194-259                 ......................SEQQILARMEADRERHKRAKEKLWMVTRES.....--Y..........SLS...............................................................................................FNEF.ENIDD..RF.S...SLQDE..DYKELREL--------krlvnks.............................................
A0A024XJI0_YEASX/223-290             ...................nan---ILLHRMEADRELHKRSKETSWYIERPS.....-ND..........ILD...............................................................................................ESEF.KSLWT..HF.E...TTDSG..FDKDDYKNIKALNDI-a...................................................
A5DDQ1_PICGU/225-294                 ......................TKKQILMRMEDDRESHKRSKESLWLVNRPR.....DTN..........VIT...............................................................................................EDEFfTQYWT..KI.K...PFDDG..EKASFLQNLDDLNKMV....................................................
A0A015KX64_9GLOM/1-55                ......................--------MEDDRERAKLLREDSWWVDKSV.....---..........--E...............................................................................................DGEA.LALWE..ET.S...DLDEG..DYIDIITE--------nikqdss.............................................
G4N7S4_MAGO7/180-243                 .....................e-KKQIEQRIEEDRERHKRLREEIWAIPNEG.....---..........--Y...............................................................................................EAEM.DKMWE..ET.S...DLGED..DHIMGEEEKEEREE--wl..................................................
A0A016PP28_GIBZA/176-238             ......................DKRQIEQRIEEDRERHKRERESIWAIPKID.....---..........---...............................................................................................NAEM.DRLWE..ET.S...DFGED..DDRLITEEQRDFE---kem.................................................
A0A024XYK8_YEASX/223-290             ...................nan---ILLHRMEADRELHKRSKETSWYIERPS.....-ND..........ILD...............................................................................................ESEF.KSLWT..HF.E...TTDSG..FDKDDYKNIKALNDI-a...................................................
R7SAN8_TREMS/158-225                 ......................SKNDILRRMEEDRERHKRLRERIWILPIPPl..leE--..........--Kdrtk......................................................................................gmdplNVEF.DQLWE..NV.S...DLDED..DLEKMKE---------....................................................
R7SME3_DICSQ/168-254                 ...................dpf---EIKKRMEEDRERHKRLRERRWVQPISHn...lY--..........--Glhplasflplt.........................................................................ddgdgpgeltlDIEF.DNEWE..TT.S...DWNED..DDEAIAEENAMC----yp..................................................
G9P4Q4_HYPAI/184-246                 ......................DKRQVEQRIEEDRERHKRERERIWAVPKGE.....---..........---...............................................................................................DAEM.NKLWE..ET.S...DFGDD..DDRLLTEEGDDF----tkem................................................
K2S301_MACPH/170-232                 ......................DKRQVEQRIEEDRERHKRLREVIWQVDPEN.....---..........---...............................................................................................DGEF.EKMWE..ES.S...DIGDD..DYMAAEEDAEERKQA-i...................................................
W9YSG3_9EURO/187-249                 ......................DKRAIEQRIEEDRERNKRLRESVWAVTGDD.....---..........---...............................................................................................DQEL.EKMWE..EG.N...YLGED..ERVIAAEEAEERL---qft.................................................
G1X440_ARTOA/233-311                 .....................p-KQVIEERMEEDRERHKRLRETIWAIYPSR.....DDE..........SLDksldg.....................................................................................leglvGPEF.EMFWK..DV.Tl.vEINED..DMELMAEEAE------lkve................................................
G8ZNJ7_TORDC/217-282                 .....................s-SSTILHRMENDREKHKRLKENNWVLERPS.....-IS..........IVD...............................................................................................PQEF.RSMWE..NE.P...Y--NT..LTKQDYKNIKDLNRI-a...................................................
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A0A022TH01_TRIRU/173-235             ......................DRKQIEQRVEEDRERNKRLRENMWAVPPHD.....---..........---...............................................................................................MKEF.EKMWD..EV.S...DVGDD..DYLQAAEEAEERRRT-a...................................................
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W0T469_KLUMA/253-316                 ....................lp---TVLHRMENDRERHKKSKEHRWFIERDD.....---..........MMD...............................................................................................TIEF.DTIWN..SF.S...L---G..MNRNDYQNIKTIQEI-aqa.................................................
N4USW3_COLOR/176-238                 .....................e-KRQIEQRIEEDRERHKRLRESIWAIPPQP.....---..........---...............................................................................................NAET.DKIWE..ET.S...DLGDD..DHILGEEELAEWGQA-m...................................................
F8NQE9_SERL9/180-268                 ......................SRGEIFKRIEEDRERHKRLRERRWVQPVSHtpfshT--..........--Qhlaaflpltd...........................................................................dqdgaeeltlDIEF.ENEWD..AT.S...DWNED..DVEAATEESELCF---st..................................................
E9D837_COCPS/169-231                 ......................DRKQIEQRVEEDRERNKRLRENMWAVPPND.....---..........---...............................................................................................IKEF.EMMWE..DV.S...DIGED..DYLQAAEEAEERRRA-g...................................................
F2SLG6_TRIRC/173-235                 ......................DRKQIEQRVEEDRERNKRLRENMWAVPPHD.....---..........---...............................................................................................MKEF.EKMWD..EV.S...DVGDD..DYLQAAEEAEERRRT-a...................................................
Q7RYU9_NEUCR/237-297                 ......................DKKQVEQRIEEDRERHKRLRENIWAVPSGD.....---..........---...............................................................................................--EL.DRLLE..ET.S...ELGDD..DMRAIWEEQEEWER--sl..................................................
G0SHE8_CHATD/186-248                 ......................DKRQIEQRIEEDRERHKRQRENIWAIPPGE.....---..........---...............................................................................................DAEL.QKLWE..ET.S...DLGED..DHRMGEEEYAEWKS--qm..................................................
J3KFY1_COCIM/169-231                 ......................DRKQIEQRVEEDRERNKRLRENMWAVPPND.....---..........---...............................................................................................IKEF.EMMWE..DV.S...DIGED..DYLQAAEEAEERRRA-g...................................................
V5FCA5_BYSSN/174-236                 ......................DKRQIEQRIEEDRERNKRLRESMWAVNGDD.....---..........---...............................................................................................GEEN.GKFWD..DA.S...DTGED..DFLGAEEEIMERRQM-f...................................................
G3Y2S4_ASPNA/180-242                 ......................DKRQIEQRIEEDRERNKRLRESMWTVSGDD.....---..........---...............................................................................................GDEH.GKFWD..EA.S...DIGED..DFLAANEEVMERRQM-i...................................................
X0ABL8_FUSOX/178-240                 ......................DKRQIEQRIEEDRERHKRERESIWAVPKAE.....---..........---...............................................................................................NAEM.DRLWE..ET.S...DFGED..DDRLLTEELDDFQK--em..................................................
C5FNA0_ARTOC/170-232                 ......................DRKQIEQRVEEDRERNKRLRENMWAVPPHD.....---..........---...............................................................................................MKEF.EKMWD..EV.S...DVGED..DYLQAAEEAEERRRT-a...................................................
G0RD12_HYPJQ/175-237                 ......................DKRQVEQRIEEDRERHKRERERIWAVPKGE.....---..........---...............................................................................................DAEM.TKLWE..ET.S...DFGED..DDRLLTEEGDDF----tkem................................................
W9ITR4_FUSOX/177-239                 ......................DKRQIEQRIEEDRERHKRERESIWAVPKAE.....---..........---...............................................................................................NAEM.DRLWE..ET.S...DFGED..DDRLLTEELDDFQK--em..................................................
X0MFV1_FUSOX/177-239                 ......................DKRQIEQRIEEDRERHKRERESIWAVPKAE.....---..........---...............................................................................................NAEM.DRLWE..ET.S...DFGED..DDRLLTEELDDFQK--em..................................................
W7DZ26_COCVI/172-234                 ......................DKRQIEQRIEEDRERHKRLRESIWAVPGDG.....---..........---...............................................................................................YEEF.EKLWE..EA.S...DVNED..DYVTAREDAEERRKV-i...................................................
A0A022YHJ3_TRIRU/173-235             ......................DRKQIEQRVEEDRERNKRLRENMWAVPPHD.....---..........---...............................................................................................MKEF.EKMWD..EV.S...DVGDD..DYLQAAEEAEERRRT-a...................................................
Q2UEY0_ASPOR/170-232                 ......................DKRQIEQRIEEDRERNKRLRESMWTVSGDD.....---..........---...............................................................................................GDEH.GKFWD..ET.S...DIGED..DFLAANEEFIERRQM-v...................................................
W7PBE1_YEASX/223-290                 ...................nan---ILLHRMEADRELHKRSKETSWYIERPS.....-ND..........ILD...............................................................................................ESEF.KSLWT..HF.E...TTDSG..FDKDDYKNIKALNDI-a...................................................
A0A023A8Z7_TRIRU/173-235             ......................DRKQIEQRVEEDRERNKRLRENMWAVPPHD.....---..........---...............................................................................................MKEF.EKMWD..EV.S...DVGDD..DYLQAAEEAEERRRT-a...................................................
M3HPL3_CANMX/213-283                 ......................SKRSILARMEDDREAHKRSKENLWMVNRDQ....aKGN..........FVT...............................................................................................EDEFiEHYWN..RF.Q...PLNEE..ENKEFLTSLQDLNES-v...................................................
S9X0S8_SCHCR/153-214                 ......................SRADILKRLEEDRERHKRMRENIWAIAKP-.....---..........---...............................................................................................EIEP.EIAWN..TI.E...PITEG..DLESLNDDFVRFNEC-i...................................................
M5BZ67_THACB/105-265                 .....................e-RDEIFKRIEEDRERHKLLRQRRWNVPTRVgq.pyA--..........--PrlasavptarilplnpvptsptspivpshltsptasthpldpnpstgagpggmpppapkhlpprhalrksyteaqrerqrqrsrtggedaqetalDIEF.EQAWE..TT.S...DWNED..DIDAVIEES-------glcw................................................
I4YBM6_WALSC/154-250                 ......................STKDILRRFEEDRERHKRLREDIWVLPISNf..tkEDA..........MNYqtpspevkqqfa......................................................................snlltfndnnkslDIEF.DNRWD..EI.S...DYNED..DVEEMLDDLNSLHRA-q...................................................
A1DHB8_NEOFI/175-237                 ......................DKRQIEQRIEEDRERNKRLRESMWTVSGDD.....---..........---...............................................................................................GDEH.GKFWD..EV.S...DIGED..DFLGAQEELMERNQMV....................................................
B2WIA8_PYRTR/173-235                 .....................g-KREIEQRIEEDRERHKRLRESIWAVNGDG.....---..........---...............................................................................................YEEL.ERLWE..EA.S...DIGED..DYVTAREDAEERKRV-i...................................................
M2SML1_COCSN/172-234                 ......................DKRQIEQRIEEDRERHKRLRESIWAVPGDG.....---..........---...............................................................................................YEEF.EKLWE..EA.S...DVNED..DYVTAREDAEERRKV-i...................................................
E3QCM0_COLGM/175-237                 .....................e-KRQIEQRIEEDRERHKRLRENIWAIGTHE.....---..........---...............................................................................................TAEI.DKIWD..ET.S...DLGDD..DHILAEEEFVACTQA-m...................................................
G2Y0N2_BOTF4/221-284                 ......................DKRQIEQRIEEDRERHKRLREHIWAVPATG.....---..........--P...............................................................................................NSEF.DKLWD..ET.S...DLGDD..DMDLYEEEAMERKEA-g...................................................
R9P245_PSEHS/159-261                 ....................pn---DMQRRIEEDRERHKRLRERSWILPPTA....fSHT..........--Tlfgtrpeqldptyltrkqs.........................................................asprekkedtdgeriwttqDLDF.SAMWE..ET.S...DFNDD..DEEDLREG--------ektfwa..............................................
B8P6Q8_POSPM/169-261                 .....................p-RAEVFKRIEEDRERHKRLRERRWVQPVSH.....--A..........VTThlppplaaflpla....................................................................gednggdsagdlplDIEF.ENDWE..TT.S...DWNED..DDDAAMEENQLC----fps.................................................
M2NIV7_BAUCO/189-254                 ......................DKRQIEQRIEEDRERHKRARETIWAVPQEG.....-ST..........LKD...............................................................................................DAEF.DKTWD..GA.S...EVNDD..DWQLTAEGAEER----av..................................................
M9LVD5_PSEA3/555-657                 ..................eagd----MQRRIEEDRERHKRLRERAWILPATAy...tSQS..........L-Fgtrpeqldptyltrtqta...........................................................spraerhdvdgdrvwttqDLDF.SHMWE..ET.S...DFNDD..DVEAIQEDLK------lsw.................................................
F9X7G0_MYCGM/167-237                 ......................DKRQIEQRIEEDRERHKRAREGIWAIAQQQ.....-HSm.......ggLAV...............................................................................................DAEF.EKLWE..DG.S...VVDDD..DYQMAREEAEERRK--hl..................................................
I2G4V8_USTH4/161-262                 ....................pn---DMQRRIEEDRERHKRLRERSWILPPTA....fTHQ..........--Slfgtrpeqldsthltrvqr.........................................................psnkveekdadgdgvwntqDLDF.NQMWE..ET.S...DFNDD..DVEDILEDEK------lsw.................................................
C4Y6A2_CLAL4/232-301                 ......................SKKQILSRMEDDRETHKKSKETLWVVNRPS.....GKS..........ALT...............................................................................................EVEFaNYYWN..RS.G...NYSEK..MKNDFFTAFDELNKI-a...................................................
V5GW19_PSEBG/158-258                 ...................ptd----MQRRIEEDRERHKRLRERSWILPPTA....fSHQ..........SLFgtrpeqldptyltrkqpa...........................................................spreqredtdgdrvwstqDLDF.SQMWD..ET.S...DFNDD..DVEGIVEDEK------tg..................................................
W9XQC7_9EURO/195-257                 ......................DKRAIEQRIEEDRERNKRLRESVWAVTGDD.....---..........---...............................................................................................DQEL.DKMWE..EG.A...LLGED..EHVIAEEEAEERLQ--fv..................................................
W3VPU4_9BASI/554-656                 ..................eagd----MQRRIEEDRERHKRLRERAWILPATAy...tSQS..........L-Fgtrpeqldptyltrtqta...........................................................spraerddvdgdrvwttqDLDF.SHMWE..ET.S...DFNDD..DVEAIQEDLK------lsw.................................................
A0A017SL42_9EURO/171-233             ......................DKRQIEQRIEEDRERNKRLRESMWTVSGDD.....---..........---...............................................................................................GEEH.GRFWD..EL.S...DVGED..DFVNANEEHMERKQMV....................................................
W9KMZ2_FUSOX/177-239                 ......................DKRQIEQRIEEDRERHKRERESIWAVPKAE.....---..........---...............................................................................................NAEM.DRLWE..ET.S...DFGED..DDRLLTEELDDFQK--em..................................................
C9SUW7_VERA1/185-246                 ......................DKRQIEQRIEEDRERHKRLREDIWAIRDR-.....---..........---...............................................................................................DAEI.DRLWE..ET.S...DLGED..DHTMGREEFLAREA--av..................................................
N1JNF4_BLUG1/167-231                 .....................d-RKVAEQRIEEDRERHKRLRENIWAIPTPS.....---..........-AE...............................................................................................ITEA.DDLWD..NT.S...EIGED..DIDLYKEEAEERDI--cv..................................................
G8BK06_CANPC/206-275                 ......................TKKQIITRIEDDRETHKRLKENKWCVNRDK.....GPK..........FIC...............................................................................................ESEFlNNYWN..KC.Q...PLTKE..ENAEFLNNLKELNDMV....................................................
W6ZDN1_COCMI/172-234                 ......................DKRQIEQRIEEDRERHKRLRESIWAVPGEG.....---..........---...............................................................................................YEEF.EKLWE..EA.S...DVNED..DYVTAREDAEERRKV-i...................................................
E6ZKK9_SPORE/159-254                 ....................pn---EMQRRIEEDRERHKRLRERSWILPPTA....fSHQ..........SLFgvrpeqldptyaasp................................................................aeqngdaeadriwttqDLDF.SQMWE..ET.S...DFNDD..DVDDIVEDE-------klg.................................................
H8X4C9_CANO9/206-275                 ......................TKKQIITRIEDDRETHKRLKENRWCVNRDK.....GTK..........FIC...............................................................................................ENEFiNNYWN..KC.H...PLTKK..ENAEFLNNLQELNSMV....................................................
Q6CSE1_KLULA/278-340                 ....................ql--QTLLHRMENDRERHKKSKEHEWVIDRAT.....---..........MTD...............................................................................................TLEF.DTVWN..SY.A...---LG..MNRNDYQNIKTIQEI-a...................................................
W2RSG6_9EURO/187-249                 ......................DRKAIEQRIEEDRERNKRLREGVWAVAGDD.....---..........---...............................................................................................EQEL.EKMWD..DG.S...DLGEE..DYAIAQEEADERAQF-a...................................................
M9MWD3_ASHG1/242-305                 .....................s-ASTILHRMESDRERHKKSKEHLWFTDRDS.....--S..........MLE...............................................................................................LAEF.DALWQ..QH.R...---KG..MTRDDYQDVKQLQRI-a...................................................
H6QUJ2_PUCGT/195-275                 ......................SKKEILDRIDDDRERHKRLRERIWVLPIPS.....---..........---...............................................................................................----.-----..--.-...-----..----------------iatlspkptpnahpattytyhrsatllhtsllsagtgadrpvgphiesdlt.
D5GJJ1_TUBMM/177-242                 ....................dd--SIIQQRMEEDRERHKRLRENIWAIPFPG.....--D..........GLP...............................................................................................NPEF.EKSWD..QV.S...DLNED..DYEIMREENQI-----laas................................................
J9VS12_CRYNH/160-292                 ......................SKTDIVRRMEEDRERHKRLRERIWILPIPSl..lpSKN..........TVAapttlssstsnaspatpasphpsslvslsq..................................hqpqslhlsasvsagagagaeddmavsesalDVEF.EQIWD..RV.P...EEGLD..DDDIL-----------qmradmrrakl.........................................
B0XSN6_ASPFC/174-236                 ......................DKRQIEQRIEEDRERNKRLRESMWTVSGDD.....---..........---...............................................................................................GDEH.GKFWD..EV.S...DIGED..DFLGAQEELMERNQMV....................................................
F9FB94_FUSOF/177-239                 ......................DKRQIEQRIEEDRERHKRERESIWAVPKAE.....---..........---...............................................................................................NAEM.DRLWE..ET.S...DFGED..DDRLLTEELDDFQK--em..................................................
G9N9Q9_HYPVG/175-237                 ......................DKRQVEQRIEEDRERHKRERERIWAVPKGE.....---..........---...............................................................................................DAEM.NKLWE..ET.S...DFGDD..DDRLLTEEGDDF----tkem................................................
N1PPQ6_MYCP1/179-246                 ......................DKRQIEQRIEEDRERHKRAREGMWAVPQGD.....-QN..........LAI...............................................................................................DVEF.DKTYD..EG.S...DVDED..DYREAKEEAEERRK--hl..................................................
C5DDV0_LACTC/233-296                 .....................t-NSTILHRMESDRERHKKSKEHMWFTERDF.....---..........MLD...............................................................................................PREF.DLLWG..SL.D...GMSKN..DFADVRD---------inniaqn.............................................
K9FSK0_PEND1/1041-1103               ......................DKRQIEQRIEEDRERNKRQRESMWAMTGND.....---..........---...............................................................................................LDEY.NQMWE..EL.S...PIGED..DFIRSREEALERAEC-v...................................................
J4GH12_FIBRA/1023-1112               ....................ar--GEVFKRIEEDRERHKRLRERRWVQPVSH....nPHT..........--Hlppqlasflpl........................................................................tddgdgegeltlDIEF.ENDWE..TT.S...DWNED..DDEAAADENHLC----fps.................................................
V9DMG0_9EURO/193-255                 ......................DKRAIEQRIEEDRERNKRLRESVWTVSGDD.....---..........---...............................................................................................DQEL.DMMWE..DG.A...TLGED..EHDIADEEAEERLQ--fv..................................................
U5GYE4_USTV1/158-279                 ......................SRNDILRRIEDDRERHKRLRERIWVLPIPT.....S-L..........FIIptansnptwsnlssikpspispaspsepps...................................srihktntssstlapstsgaavqrgpevpiDLEF.EQTWA..RL.N...E----..----------------erefaelerndveg......................................
C7GV94_YEAS2/223-290                 ...................nan---ILLHRMEADRELHKRSKETSWYIERPS.....-ND..........ILD...............................................................................................ESEF.KSLWM..HF.E...TTDSG..FDKDDYKNIKALNDI-a...................................................
I1BWB2_RHIO9/154-217                 ......................SKQDILRRMEEDRERHKRIKEEIWIRPPEE.....S--..........--K...............................................................................................NAEF.EDFWN..SI.D...KLNPEvdYEQMMLQN--------rqrlp...............................................
N1NYQ0_YEASC/223-290                 ...................nan---ILLHRMEADRELHKRSKETSWYIERPS.....-ND..........ILD...............................................................................................ESEF.KSLWT..HF.E...TTDSG..FDKDDYKNIKALNDI-a...................................................
W7R6I4_YEASX/223-290                 ...................nan---ILLHRMEADRELHKRSKETSWYIERPS.....-ND..........ILD...............................................................................................ESEF.KSLWT..HF.E...TTDSG..FDKDDYKNIKALNDI-a...................................................
A2QCN2_ASPNC/180-242                 ......................DKRQIEQRIEEDRERNKRLRESMWTVSGDD.....---..........---...............................................................................................GDEH.GKFWD..EA.S...DIGED..DFLAANEEVMERRQM-i...................................................
H6C3G8_EXODN/213-275                 ......................DKRAIEQRIEEDRERNKRLRESVWAVSGDD.....---..........---...............................................................................................DQEL.DKMWE..EG.S...QLGED..DQVIAAEEADERLQ--fa..................................................
G7X5B6_ASPKW/180-242                 ......................DKRQIEQRIEEDRERNKRLRESMWTVSGDD.....---..........---...............................................................................................GDEH.GKFWD..EA.S...DIGED..DFLAANEEVMERRQM-i...................................................
K5WY59_AGABU/173-263                 ......................SRNEIFKRVEEDRERHKRLRERRWVQSITHd..ttDHR..........SLTlacflplae............................................................................saageralgiDIEF.ENEWE..TA.S...DWNED..DDDAAAEESELCFRA-e...................................................
L8WKA7_THACA/244-394                 ...................iak-------------EYHKLLRQRRWNVPTRVgq.pyA--..........--PrlasavptarilplnpvptsptspimsshlaspiapahpldsntsagtgqggmpppapkhlpprhalrksyteaqrerqrqrsrtggedaqetalDIEF.EQAWE..TT.S...DWNED..DIDAVVEECG------lcw.................................................
A0A024SLR3_HYPJE/175-237             ......................DKRQVEQRIEEDRERHKRERERIWAVPKGE.....---..........---...............................................................................................DAEM.TKLWE..ET.S...DFGED..DDRLLTEEGDDF----tkem................................................
C0SBT8_PARBP/177-239                 ......................DKRQIEQRIEEDRERNKRLRESMWAVPGND.....---..........---...............................................................................................TDEF.DKMWD..EV.S...DLGED..DYLAAEEEAMERKRI-a...................................................
A0A022VWW1_TRIRU/173-235             ......................DRKQIEQRVEEDRERNKRLRENMWAVPPHD.....---..........---...............................................................................................MKEF.EKMWD..EV.S...DVGDD..DYLQAAEEAEERRRT-a...................................................
E3KJD5_PUCGT/196-276                 ......................SKKEILDRIDDDRERHKRLRERIWVLPIPS.....---..........---...............................................................................................----.-----..--.-...-----..----------------iatlspkptanahhpattytyhrsatllhtsllsagtgadrpvgphiesdl.
X0GNN6_FUSOX/178-240                 ......................DKRQIEQRIEEDRERHKRERESIWAVPKAE.....---..........---...............................................................................................NAEM.DRLWE..ET.S...DFGED..DDRLLTEELDDFQK--em..................................................
G4TB04_PIRID/183-298                 ......................SRSQAMRRIEEDRERHKLLRERRWVQQVDR.....SDS..........TQPtlavllpnslppiavsksmpptps..............................................damdtdetaragsdsrpqnspqlaiDIEF.ENAWE..TT.S...DWNED..DIDAVYEEYMLC----fp..................................................
Q6C0W5_YARLI/181-242                 .....................t-NAQKLKRMEEDRERSKMERENAWVIGRN-.....---..........---...............................................................................................EDEF.ELQWD..AL.D...GGFTA..LDKYETQEENEMCQL-a...................................................
#=GC seq_cons                        ......................s++pIppRIEEDRERHKRhREshWslPtss....................................................................................................................psEa.-phW-..-s.S...Dhs-D..D.thhtEEhp-hpp..t...................................................
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