GenomeNet

Database: Pfam
Entry: CTK3_C
LinkDB: CTK3_C
Original site: CTK3_C 
#=GF ID   CTK3_C
#=GF AC   PF12350.3
#=GF DE   CTD kinase subunit gamma CTK3 C-terminus
#=GF AU   Wood V, Coggill P
#=GF SE   Pfam-B_12814 (release 23.0)
#=GF GA   25.00 25.00;
#=GF TC   33.20 37.90;
#=GF NC   18.30 18.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   11118453
#=GF RT   Activation of the cyclin-dependent kinase CTDK-I requires the
#=GF RT   heterodimerization of two unstable subunits.
#=GF RA   Hautbergue G, Goguel V;
#=GF RL   J Biol Chem. 2001;276:8005-8013.
#=GF RN   [2]
#=GF RM   16721054
#=GF RT   Bur1/Bur2 and the Ctk complex in yeast: the split personality of
#=GF RT   mammalian P-TEFb.
#=GF RA   Wood A, Shilatifard A;
#=GF RL   Cell Cycle. 2006;5:1066-1068.
#=GF DR   INTERPRO; IPR024637;
#=GF CC   The C-terminal domain kinase (CTDK-1), is a three-subunit
#=GF CC   complex comprised of Ctk1, Ctk2, and Ctk3, that plays a key role
#=GF CC   in regulation of transcription and translation and in
#=GF CC   coordinating these two processes. Both Ctk2 and Ctk3 are
#=GF CC   regulated at the level of protein turnover, and are unstable
#=GF CC   proteins processed through a ubiquitin-proteasome pathway. Their
#=GF CC   physical interaction is required to protect both subunits from
#=GF CC   degradation, and both Ctk2 and Ctk3 are required for Ctk1 CTD
#=GF CC   kinase activation [1]. The mammalian P-TEFb is mirrored by the
#=GF CC   combined complexes in yeast of the CTDK1 and the Bur1/2 [2]. It
#=GF CC   is not clear what independent function this C-terminal domain
#=GF CC   has.
#=GF SQ   130
#=GS G1X440_ARTOA/232-310  AC G1X440.1
#=GS D4CZT4_TRIVH/172-237  AC D4CZT4.1
#=GS G0SHE8_CHATD/185-250  AC G0SHE8.1
#=GS G0WAS8_NAUDC/324-402  AC G0WAS8.1
#=GS F9FB94_FUSOF/176-240  AC F9FB94.1
#=GS G8BK06_CANPC/205-277  AC G8BK06.1
#=GS E7KG57_YEASA/221-286  AC E7KG57.1
#=GS C0SBT8_PARBP/176-241  AC C0SBT8.1
#=GS Q4X0V8_ASPFU/173-238  AC Q4X0V8.1
#=GS A5DDQ1_PICGU/224-296  AC A5DDQ1.2
#=GS B6QK65_PENMQ/169-234  AC B6QK65.1
#=GS Q2H6I6_CHAGB/123-188  AC Q2H6I6.1
#=GS H1UZN1_COLHI/174-239  AC H1UZN1.1
#=GS E9DSP1_METAQ/175-240  AC E9DSP1.1
#=GS C4Y6A2_CLAL4/231-303  AC C4Y6A2.1
#=GS E7KSA6_YEASL/221-292  AC E7KSA6.1
#=GS G8BQW3_TETPH/241-310  AC G8BQW3.1
#=GS A6R2P3_AJECN/177-242  AC A6R2P3.1
#=GS C7YNK1_NECH7/176-241  AC C7YNK1.1
#=GS C1GIQ9_PARBD/176-241  AC C1GIQ9.1
#=GS Q0CYT5_ASPTN/174-239  AC Q0CYT5.1
#=GS B5RUA8_DEBHA/232-304  AC B5RUA8.1
#=GS A2QCN2_ASPNC/179-244  AC A2QCN2.1
#=GS G2X794_VERDV/184-248  AC G2X794.1
#=GS G8YFL3_PICSO/233-305  AC G8YFL3.1
#=GS E7NL69_YEASO/221-292  AC E7NL69.1
#=GS D5GJJ1_TUBMM/176-242  AC D5GJJ1.1
#=GS Q6C0W5_YARLI/180-244  AC Q6C0W5.1
#=GS B3LLE7_YEAS1/221-292  AC B3LLE7.1
#=GS F8PTJ2_SERL3/179-270  AC F8PTJ2.1
#=GS H8X4C9_9ASCO/205-277  AC H8X4C9.1
#=GS Q0U2X2_PHANO/161-226  AC Q0U2X2.1
#=GS G9P4Q4_HYPAI/183-250  AC G9P4Q4.1
#=GS H6QUJ2_PUCGT/194-243  AC H6QUJ2.1
#=GS G7DWG1_MIXOS/154-200  AC G7DWG1.1
#=GS Q55NS7_CRYNB/158-208  AC Q55NS7.1
#=GS G2Y0N2_BOTF4/220-286  AC G2Y0N2.1
#=GS G8JSB3_ERECY/225-291  AC G8JSB3.1
#=GS B2WIA8_PYRTR/172-237  AC B2WIA8.1
#=GS C5FNA0_ARTOC/169-234  AC C5FNA0.1
#=GS I1RSW9_GIBZE/175-240  AC I1RSW9.1
#=GS F9X7G0_MYCGM/166-239  AC F9X7G0.1
#=GS Q2UEY0_ASPOR/169-234  AC Q2UEY0.1
#=GS G2WJU4_YEASK/221-292  AC G2WJU4.1
#=GS G0VAZ5_NAUCC/225-297  AC G0VAZ5.1
#=GS G4N7S4_MAGO7/179-245  AC G4N7S4.1
#=GS G2R8Z4_THITE/187-252  AC G2R8Z4.1
#=GS H0EGK1_GLAL7/106-173  AC H0EGK1.1
#=GS CTK3_SCHPO/152-216    AC Q9USJ8.1
#=GS A3LWA0_PICST/220-292  AC A3LWA0.2
#=GS C4YKX2_CANAW/211-284  AC C4YKX2.1
#=GS E7QIS3_YEASZ/221-292  AC E7QIS3.1
#=GS Q6CSE1_KLULA/277-342  AC Q6CSE1.1
#=GS A6RQX5_BOTFB/220-286  AC A6RQX5.1
#=GS C7GV94_YEAS2/221-292  AC C7GV94.1
#=GS E9F120_METAR/175-240  AC E9F120.1
#=GS B5VP19_YEAS6/221-292  AC B5VP19.1
#=GS D8PNY1_SCHCM/174-262  AC D8PNY1.1
#=GS E9D837_COCPS/168-233  AC E9D837.1
#=GS Q5AZG8_EMENI/174-239  AC Q5AZG8.1
#=GS F2T3F1_AJEDA/177-242  AC F2T3F1.1
#=GS A7TIV8_VANPO/234-300  AC A7TIV8.1
#=GS E3L3V5_PUCGT/195-244  AC E3L3V5.1
#=GS C9SUW7_VERA1/184-248  AC C9SUW7.1
#=GS E6ZKK9_SPORE/157-253  AC E6ZKK9.1
#=GS B8P6Q8_POSPM/168-263  AC B8P6Q8.1
#=GS G3J5K0_CORMM/259-324  AC G3J5K0.1
#=GS C5PBY2_COCP7/167-232  AC C5PBY2.1
#=GS F2SLG6_TRIRC/172-237  AC F2SLG6.1
#=GS G0RD12_HYPJQ/174-240  AC G0RD12.1
#=GS A8N4W9_COPC7/199-263  AC A8N4W9.2
#=GS B6JZW0_SCHJY/155-218  AC B6JZW0.1
#=GS G8YD60_PICSO/233-305  AC G8YD60.1
#=GS H6C3G8_EXODN/212-277  AC H6C3G8.1
#=GS Q4PHG1_USTMA/157-221  AC Q4PHG1.1
#=GS Q5A5P9_CANAL/211-284  AC Q5A5P9.1
#=GS E3QCM0_COLGM/174-239  AC E3QCM0.1
#=GS G3Y2S4_ASPNA/179-244  AC G3Y2S4.1
#=GS G7X5B6_ASPKW/179-244  AC G7X5B6.1
#=GS H2AMW6_KAZAF/178-251  AC H2AMW6.1
#=GS CTK3_YEAST/221-292    AC P46963.2
#=GS F0XAN8_GROCL/237-300  AC F0XAN8.1
#=GS D4AWM3_ARTBC/118-183  AC D4AWM3.1
#=GS B2AXB6_PODAN/207-272  AC B2AXB6.1
#=GS H0GLN3_9SACH/221-292  AC H0GLN3.1
#=GS B8MLI2_TALSN/169-234  AC B8MLI2.1
#=GS G4UN83_NEUT9/230-293  AC G4UN83.1
#=GS A1DHB8_NEOFI/174-239  AC A1DHB8.1
#=GS G3ALU7_SPAPN/217-289  AC G3ALU7.1
#=GS C5DDV0_LACTC/232-296  AC C5DDV0.1
#=GS F2S8P6_TRIT1/172-237  AC F2S8P6.1
#=GS F4RIT2_MELLP/198-240  AC F4RIT2.1
#=GS B9WCX2_CANDC/211-284  AC B9WCX2.1
#=GS E3KJD5_PUCGT/195-244  AC E3KJD5.1
#=GS C4R1L6_PICPG/193-258  AC C4R1L6.1
#=GS C0NDA5_AJECG/177-242  AC C0NDA5.1
#=GS B6HHC9_PENCW/167-232  AC B6HHC9.1
#=GS B0D9N2_LACBS/209-288  AC B0D9N2.1
#=GS Q7RYU9_NEUCR/236-299  AC Q7RYU9.1
#=GS E7LYJ3_YEASV/221-292  AC E7LYJ3.1
#=GS A1C6P7_ASPCL/173-238  AC A1C6P7.1
#=GS C8ZE91_YEAS8/221-292  AC C8ZE91.1
#=GS E3RGG4_PYRTT/172-237  AC E3RGG4.1
#=GS F0UJU6_AJEC8/177-242  AC F0UJU6.1
#=GS B8NGF7_ASPFN/169-234  AC B8NGF7.1
#=GS F2QS45_PICP7/193-258  AC F2QS45.1
#=GS G3BCQ9_CANTC/225-297  AC G3BCQ9.1
#=GS C5JSH2_AJEDS/177-242  AC C5JSH2.1
#=GS F8NQE9_SERL9/179-270  AC F8NQE9.1
#=GS Q6FP45_CANGA/276-345  AC Q6FP45.1
#=GS B0XSN6_ASPFC/173-238  AC B0XSN6.1
#=GS C5GDX3_AJEDR/177-242  AC C5GDX3.1
#=GS E5A0V7_LEPMJ/165-230  AC E5A0V7.1
#=GS F2Q3P9_TRIEC/172-237  AC F2Q3P9.1
#=GS G2QDU9_THIHA/182-247  AC G2QDU9.1
#=GS G8ZNJ7_TORDC/216-284  AC G8ZNJ7.1
#=GS C4JXE8_UNCRE/121-186  AC C4JXE8.1
#=GS A5DY84_LODEL/218-292  AC A5DY84.1
#=GS F8ML44_NEUT8/230-293  AC F8ML44.1
#=GS E4UMM0_ARTGP/172-237  AC E4UMM0.1
#=GS C5E0M7_ZYGRC/202-270  AC C5E0M7.1
#=GS A6ZLV2_YEAS7/221-292  AC A6ZLV2.1
#=GS I1BWB2_RHIO9/153-216  AC I1BWB2.1
#=GS F7WB08_SORMK/232-285  AC F7WB08.1
#=GS C1GNM2_PARBA/176-241  AC C1GNM2.1
#=GS C6HK49_AJECH/177-242  AC C6HK49.1
#=GS F4NU91_BATDJ/167-241  AC F4NU91.1
#=GS G4TB04_PIRID/182-221  AC G4TB04.1
#=GS Q75E03_ASHGO/241-307  AC Q75E03.1
#=GS G9N9Q9_HYPVG/174-239  AC G9N9Q9.1
G1X440_ARTOA/232-310             ..pp--KQVI.EERMEEDRERHKRLRETIWAIYPSRd.....dE.SLdksld.....................gleglVGPEF.EMFWKDVTlvEINEDDMELMAE-----------eaelkv.............
D4CZT4_TRIVH/172-237             ...v-DRKQI.EQRVEEDRERNKRLRENMWAVPPHD.......-.--...............................-MKEF.EKMWDEVS..DVGDDDYLQAAEEAEERRRTAE-a..................
G0SHE8_CHATD/185-250             ....LDKRQI.EQRIEEDRERHKRQRENIWAIPPGE.......-.--...............................-DAEL.QKLWEETS..DLGEDDHRMGEEEYAEWKSQMK-a..................
G0WAS8_NAUDC/324-402             ..pi-----I.IRRMENDRERHKRLKEKSWVVDRNIqr...qrQ.-Kgqpln....................tkklilNVNEF.ESLWNNTN..V--NKLTIDDIKNMKEMNLIAK-q..................
F9FB94_FUSOF/176-240             ....LDKRQI.EQRIEEDRERHKRERESIWAVPKAE.......-.--...............................-NAEM.DRLWEETS..DFGEDDDRLLTEELDDFQK----eme................
G8BK06_CANPC/205-277             ....LTKKQI.ITRIEDDRETHKRLKENKWCVNRDKg.....pK.FI...............................CESEFlNNYWNKCQ..PLTKEENAEFLNNLKELNDMV--ls.................
E7KG57_YEASA/221-286             .ptn---ANIlLHRMEADRELHKRSKETSWYIERPS.......NdIL...............................DESEF.KSLWTHFE..TTDSGFDKERLQKX---------srl................
C0SBT8_PARBP/176-241             ....VDKRQI.EQRIEEDRERNKRLRESMWAVPGND.......-.--...............................-TDEF.DKMWDEVS..DLGEDDYLAAEEEAMERKRIAEE...................
Q4X0V8_ASPFU/173-238             ....VDKRQI.EQRIEEDRERNKRLRESMWTVSGDD.......-.--...............................-GDEH.GKFWDEVS..DIGEDDFLGAQEELMERNQMVA-a..................
A5DDQ1_PICGU/224-296             ....LTKKQI.LMRMEDDRESHKRSKESLWLVNRPRd.....tN.VI...............................TEDEFfTQYWTKIK..PFDDGEKASFLQNLDDLNKMVA-a..................
B6QK65_PENMQ/169-234             ....VDKRQI.EQRIEEDRERNKRLRESMWTVSGDN.......-.--...............................-KGEF.QQCWDEVS..DIGEDDYLGAEEEFGERRQMVT-a..................
Q2H6I6_CHAGB/123-188             ....LDKKQT.EQRIEEDRERHKRQRENIWAVPPGE.......-.--...............................-DAEM.EKLWEETS..DLGEDDHRMGEEEWAEWEA----efea...............
H1UZN1_COLHI/174-239             ....LEKRQI.EQRIEEDRERHKRLRENIWAIGAHD.......-.--...............................-NAEV.DKIWEETS..DFGDDDHILAEEEFTEFTQAMQ-h..................
E9DSP1_METAQ/175-240             ....LDKRQV.EQRIEEDRERHKRQRESIWAIPKT-.......-.--...............................EDAEM.NKLWEETS..DFGEDDDRLLSEEAEDCAKE---mem................
C4Y6A2_CLAL4/231-303             ....LSKKQI.LSRMEDDRETHKKSKETLWVVNRPS......gKsAL...............................TEVEFaNYYWNRSG..NYSEKMKNDFFTAFDELNKIAA-a..................
E7KSA6_YEASL/221-292             .ptn---ANIlLHRMEADRELHKRSKETSWYIERPS.......NdIL...............................DESEF.KSLWTHFE..TTDSGFDKDDYKNIKALNDIAKA...................
G8BQW3_TETPH/241-310             taat----QItLHRMENDRERHKKLKEHSWFIKRDTd.....rS.ML...............................SANEF.EKLWDNTT..G---ELTIEDLNNMQELHDISQ-q..................
A6R2P3_AJECN/177-242             ....VDKRQI.EQRIEEDRERNKRLRESMWAVPGND.......-.--...............................-ADEF.DKMWDEVS..DLGEDDYLAAEEEAMERKRIAEE...................
C7YNK1_NECH7/176-241             ....LDKRQI.EQRIEEDRERHKRERESIWAIPK--.......-.-V...............................ENAEM.SKLWEDTS..DFGEDDDRLLTEELADFRK----emem...............
C1GIQ9_PARBD/176-241             ....VDKRQI.EQRIEEDRERNKRLRESMWAVPGND.......-.--...............................-TDEF.DKMWDEVS..DLGEDDYLAAEEEAMERKRIAEE...................
Q0CYT5_ASPTN/174-239             ....VDKRQI.EQRIEEDRERNKRLRESMWTVRGDD.......-.--...............................-GDEH.GRFWDEAS..DIGEDDFLAANEELMERQQMAS-a..................
B5RUA8_DEBHA/232-304             ....LSKKHI.LLRMEDDRETHKRSKENIWVVNRPKd.....aS.IL...............................TEDEFlVHYWNKYR..VMAEEEEKTFMDSLDELNGLV--ve.................
A2QCN2_ASPNC/179-244             ....VDKRQI.EQRIEEDRERNKRLRESMWTVSGDD.......-.--...............................-GDEH.GKFWDEAS..DIGEDDFLAANEEVMERRQMI--ga.................
G2X794_VERDV/184-248             ....LDKRQI.EQRIEEDRERHKRLREDIWAIRD--.......-.--...............................RDAEI.DRLWEETS..DLGEDDHTMGREEFLAREAAVA-q..................
G8YFL3_PICSO/233-305             ...f-TKKQI.LMRMEDDRESHKRSKENLWVVNRPK......dSnSL...............................TEDEFlVYYWNKFG..NVTEEEDKSFRDSLNDLNAMVA-q..................
E7NL69_YEASO/221-292             .ptn---ANIlLHRMEADRELHKRSKETSWYIERPS.......NdIL...............................DESEF.KSLWTHFE..TTDSGFDKDDYKNIKALNDIAKA...................
D5GJJ1_TUBMM/176-242             ...f-DDSII.QQRMEEDRERHKRLRENIWAIPFPG.......D.GL...............................PNPEF.EKSWDQVS..DLNEDDYEIMREEN---------qilaas.............
Q6C0W5_YARLI/180-244             ....MTNAQK.LKRMEEDRERSKMERENAWVIGR--.......-.--...............................NEDEF.ELQWDALD..GGFTALDKYETQEENEMCQLAK-f..................
B3LLE7_YEAS1/221-292             .ptn---ANIlLHRMEADRELHKRSKETSWHIERPS.......NdIL...............................DESEF.KSLWTHFE..TTDSGFDKDDYKNIKALNDIAKA...................
F8PTJ2_SERL3/179-270             ....LSRGEI.FKRIEEDRERHKRLRERRWVQPVSHtp...fsH.-Tqhlaaflplt...........ddqdgaeeltLDIEF.ENEWDATS..DWNEDDVEAATEESELCF-----strd...............
H8X4C9_9ASCO/205-277             ....LTKKQI.ITRIEDDRETHKRLKENRWCVNRDK......gTkFI...............................CENEFiNNYWNKCH..PLTKKENAEFLNNLQELNSMV--ls.................
Q0U2X2_PHANO/161-226             ....MDKRQI.EQRIEEDRERHKRLRESIWAVSGEA.......-.--...............................-DEEM.EKLWEEAS..EIGEDDYVVGREDREERDQAIH-f..................
G9P4Q4_HYPAI/183-250             ....LDKRQV.EQRIEEDRERHKRERERIWAVPKGE.......-.--...............................-DAEM.NKLWEETS..DFGDDDDRLLTEEGDDFT-----kememqq............
H6QUJ2_PUCGT/194-243             ...f-SKKEI.LDRIDDDRERHKRLRERIWVLPIPS......iA.T-...............................-----.--------..-----------------------lspkptpnahpattyt...
G7DWG1_MIXOS/154-200             ...f-SHNDV.LRRIEDDRERHKRLREKIWVLPLPR.......-.--...............................-----.--------..-----------------------qieplrrlasalptaq...
Q55NS7_CRYNB/158-208             ...f-SKTDI.VRRMEEDRERHKRLRERIWILPIPS.......-.LL...............................-----.--------..-----------------------ptknnvaapttlssstsn.
G2Y0N2_BOTF4/220-286             ....LDKRQI.EQRIEEDRERHKRLREHIWAVPATG.......-.--...............................PNSEF.DKLWDETS..DLGDDDMDLYEEEAMERKEAG--re.................
G8JSB3_ERECY/225-291             ...s-SANTI.LHRMENDRERHKKSKEHLWFTERDY.......S.ML...............................EVSEF.DILWEQNR..K---GMTRDDYQDIKQLHRLAQE...................
B2WIA8_PYRTR/172-237             ...m-GKREI.EQRIEEDRERHKRLRESIWAVNGDG.......-.--...............................-YEEL.ERLWEEAS..DIGEDDYVTAREDAEERKRVI--af.................
C5FNA0_ARTOC/169-234             ...v-DRKQI.EQRVEEDRERNKRLRENMWAVPPHD.......-.--...............................-MKEF.EKMWDEVS..DVGEDDYLQAAEEAEERRRTAE-a..................
I1RSW9_GIBZE/175-240             ...f-DKRQI.EQRIEEDRERHKRERESIWAIPK--.......-.-I...............................DNAEM.DRLWEETS..DFGEDDDRLITEEQRDFEKE---mem................
F9X7G0_MYCGM/166-239             ....LDKRQI.EQRIEEDRERHKRAREGIWAIAQQQh....smG.GL..............................aVDAEF.EKLWEDGS..VVDDDDYQMAREEAEERRKH---lef................
Q2UEY0_ASPOR/169-234             ....VDKRQI.EQRIEEDRERNKRLRESMWTVSGDD.......-.--...............................-GDEH.GKFWDETS..DIGEDDFLAANEEFIERRQMV--ga.................
G2WJU4_YEASK/221-292             .ptn---ANIlLHRMEADRELHKRSKETSWYIERPS.......NdIL...............................DESEF.KSLWTHFE..TTDSGFDKDDYKNIKALNDIAKA...................
G0VAZ5_NAUCC/225-297             .vlt---TTI.LHRMENDRERHKRMKEQRWIIERGNql...nkKtIL...............................DEQEF.KLLWENQD..N--NTLTTDDIKNVKEMNLIAN-q..................
G4N7S4_MAGO7/179-245             ....LEKKQI.EQRIEEDRERHKRLREEIWAIPNEG.......-.--...............................YEAEM.DKMWEETS..DLGEDDHIMGEEEKEEREEW---lrr................
G2R8Z4_THITE/187-252             ....LDKKQI.EQRMEEDRERHKRQRENIWAVPPGE.......-.--...............................-DAEM.EKLWEETS..DLGEDDHRMGEEELAEWRA----efea...............
H0EGK1_GLAL7/106-173             ...v-DRKQI.EQRIEEDRERHKRLRENIWAVPN--.......T.GV...............................EDEEF.AKMWEETS..DVGEDDFILYAEEAAERREAAR-e..................
CTK3_SCHPO/152-216               ...i-SKNDI.LKRIEEDRERHKRMRENIWAISE--.......-.--...............................PELEA.EIAWNTTQ..GITESDLESLKDEYEKFNECLH-a..................
A3LWA0_PICST/220-292             ....LTKKNI.ISRMEDDREAHKRSKETLWLVTRPP......kSsYI...............................TEDEFlNHYWNKYH..ALDVEEDNAFLDSLDELNQVVA-e..................
C4YKX2_CANAW/211-284             ....LSKRQI.LVRMEDDREAHKRSKENFWVVNRDKe....kgN.HI...............................TEDEFvSHYWNKFQ..PLNDQENKEFLNSLQELNVIVE-n..................
E7QIS3_YEASZ/221-292             .ptn---ANIlLHRMEADRELHKRSKETSWYIERPS.......NdIL...............................DESEF.KSLWTHFX..TTDSGFDKDDYKNIKALNDIAKA...................
Q6CSE1_KLULA/277-342             .sql---QTL.LHRMENDRERHKKSKEHEWVIDRAT.......-.MT...............................DTLEF.DTVWNSYA..L---GMNRNDYQNIKTIQEIAQQ...................
A6RQX5_BOTFB/220-286             ....LDKRQI.EQRIEEDRERHKRLREHIWAVPATG.......-.--...............................PNSEF.DKLWDETS..DLGDDDMDLYEEEAMERKEAG--re.................
C7GV94_YEAS2/221-292             .ptn---ANIlLHRMEADRELHKRSKETSWYIERPS.......NdIL...............................DESEF.KSLWMHFE..TTDSGFDKDDYKNIKALNDIAKA...................
E9F120_METAR/175-240             ....LDKRQV.EQRIEEDRERHKRQRESIWAIPKT-.......-.--...............................EDAEM.NKLWEETS..DFGEDDDRLLSEEAEDCVK----emem...............
B5VP19_YEAS6/221-292             .ptn---ANIlLHRMEADRELHKRSKETSWYIERPS.......NdIL...............................DESEF.KSLWTHFE..TTDSGFDKDDYKNIKALNDIAKA...................
D8PNY1_SCHCM/174-262             ....LSRNEI.FKRIEEDRERHKRLRERRWVQPVSY.......D.AVptlatflplt...........deadgerelpLDVEF.ENAWETTS..DWNEDDEEAMREENELC------fpkaa..............
E9D837_COCPS/168-233             ...v-DRKQI.EQRVEEDRERNKRLRENMWAVPPND.......-.--...............................-IKEF.EMMWEDVS..DIGEDDYLQAAEEAEERRRA---gda................
Q5AZG8_EMENI/174-239             ....VDKRQI.EQRIEEDRERNKRLRESMWTVRGDD.......-.--...............................-SDEH.RKFWDETS..DIGEDDFTTAHEELMERNEMIN-a..................
F2T3F1_AJEDA/177-242             ....VDKRQI.EQRIEEDRERNKRLRESMWAVPGND.......-.--...............................-ADEL.DKMWDEVS..DLGEDDYLAAEEEAMERKRIAEE...................
A7TIV8_VANPO/234-300             ..tt-STQIT.LHRMESDRERHKRAKEHMWFINKTN.......-.ML...............................DESEF.QNLWNKIP..N---SLTAEDLTSIQEIQSIAK-q..................
E3L3V5_PUCGT/195-244             ...f-SKKEI.LDRIDDDRERHKRLRERIWVLPIPS......iA.T-...............................-----.--------..-----------------------lspkptanahhpatty...
C9SUW7_VERA1/184-248             ....LDKRQI.EQRIEEDRERHKRLREDIWAIRD--.......-.--...............................RDAEI.DRLWEETS..DLGEDDHTMGREEFLAREAAVA-q..................
E6ZKK9_SPORE/157-253             lppn----EM.QRRIEEDRERHKRLRERSWILPPTAf....shQ.SLfgvrpeqldptyaaspaeqngdaeadriwttQDLDF.SQMWEETS..DFNDDDVDDIVED----------ekl................
B8P6Q8_POSPM/168-263             ..lp--RAEV.FKRIEEDRERHKRLRERRWVQPVSHa.....vTtHLppplaaflplag.......ednggdsagdlpLDIEF.ENDWETTS..DWNEDDDDAAMEENQLC------fpshd..............
G3J5K0_CORMM/259-324             ....LDKRQV.EQRIEEDRERHKRERESIWAVPKGD.......-.--...............................-GAEM.DKLWEETS..DFGEDDDRLITEENADFD-----temem..............
C5PBY2_COCP7/167-232             ...v-DRKQI.EQRVEEDRERNKRLRENMWAVPPND.......-.--...............................-IKEF.EMMWEDVS..DIGEDDYLQAAEEAEERRRA---gda................
F2SLG6_TRIRC/172-237             ...v-DRKQI.EQRVEEDRERNKRLRENMWAVPPHD.......-.--...............................-MKEF.EKMWDEVS..DVGDDDYLQAAEEAEERRRTAE-a..................
G0RD12_HYPJQ/174-240             ....LDKRQV.EQRIEEDRERHKRERERIWAVPKGE.......-.--...............................-DAEM.TKLWEETS..DFGEDDDRLLTEEGDDFT-----kememq.............
A8N4W9_COPC7/199-263             ....MSKNDV.FKRIEEDRERHKRLRERRWVQPISY.......-.--...............................ASSSFnPKHMPLAS..F----------------------lpltttsktsagqdqaape
B6JZW0_SCHJY/155-218             ...f-SREDI.LRRMEEDRERHKRLRETFWAVDS--.......-.--...............................PEEEW.QQTWASLP..ALNDHDLEKIRDEYAKYKSCT--q..................
G8YD60_PICSO/233-305             ...f-TKKQI.LMRMEDDRESHKRSKENLWVVNRPK......dSnSL...............................TEDEFlVYYWNKFG..NVTEEEDKSFRESLNDLNAMVA-q..................
H6C3G8_EXODN/212-277             ....MDKRAI.EQRIEEDRERNKRLRESVWAVSGDD.......-.--...............................-DQEL.DKMWEEGS..QLGEDDQVIAAEEADERLQFA--ry.................
Q4PHG1_USTMA/157-221             ..lp--ASDI.QRRIEEDRERHKRLRERSWILPP--.......-.--...............................TAFSH.TSLFGIKP..EQLDPTYLTRKQDASPCERSE--ds.................
Q5A5P9_CANAL/211-284             ....LSKRQI.LVRMEDDREAHKRSKENFWVVNRDKe....kgN.HI...............................TEDEFvNHYWNKFQ..PLNDQENKEFLNSLQELNVIVE-n..................
E3QCM0_COLGM/174-239             ....LEKRQI.EQRIEEDRERHKRLRENIWAIGTHE.......-.--...............................-TAEI.DKIWDETS..DLGDDDHILAEEEFVACTQAMN-h..................
G3Y2S4_ASPNA/179-244             ....VDKRQI.EQRIEEDRERNKRLRESMWTVSGDD.......-.--...............................-GDEH.GKFWDEAS..DIGEDDFLAANEEVMERRQMI--ga.................
G7X5B6_ASPKW/179-244             ....VDKRQI.EQRIEEDRERNKRLRESMWTVSGDD.......-.--...............................-GDEH.GKFWDEAS..DIGEDDFLAANEEVMERRQMI--ga.................
H2AMW6_KAZAF/178-251             ...i-SQNDV.LNRMEADRERHKRTKESNWIVERATlpndsnkNvML...............................QYSEF.DSMWNGTN..KIDEVDMSYI-------------rqlneistn..........
CTK3_YEAST/221-292               .ptn---ANIlLHRMEADRELHKRSKETSWYIERPS.......NdIL...............................DESEF.KSLWTHFE..TTDSGFDKDDYKNIKALNDIAKA...................
F0XAN8_GROCL/237-300             ....LDKKQI.EERIEEDRERHKRLRENIWAVPGG-.......-.--...............................TDTEM.WKIWEETS..ELGEDDHVMGEEEQAERSR----nl.................
D4AWM3_ARTBC/118-183             ...v-DRKQI.EQRVEEDRERNKRLRENMWAVPPHD.......-.--...............................-MKEF.EKMWDEVS..DVGDDDYLQAAEEAEERRRTAE-a..................
B2AXB6_PODAN/207-272             ....LDRKQV.EQRIEEDRERHKRQREGIWAVSPEN.......-.--...............................-EAEL.RKLWEETS..ELGEDDERMCDEEWEEWEEAM--gg.................
H0GLN3_9SACH/221-292             .ptn---ANIlLHRMEADRELHKRSKETSWYIERPS.......NdIL...............................DESEF.KSLWTHFE..TTDSGFDKDDYKNIKALNDIAKA...................
B8MLI2_TALSN/169-234             ....VDKRQI.EQRIEEDRERNKRLRESMWTVSGNN.......-.--...............................-KGEF.QQCWDDVS..DIGDDDFLGAEEECAERKQMVT-a..................
G4UN83_NEUT9/230-293             ....LDKKQV.EQRIEEDRERHKRLRENIWAVPS--.......-.--...............................-GEEM.DRLLEETS..ELGDDDMRAIWEEQEEWERSLQ-a..................
A1DHB8_NEOFI/174-239             ....VDKRQI.EQRIEEDRERNKRLRESMWTVSGDD.......-.--...............................-GDEH.GKFWDEVS..DIGEDDFLGAQEELMERNQMVA-a..................
G3ALU7_SPAPN/217-289             ....LSKRQI.LSRMEDDREAHKRSKENLWVVNRDK......nSsFI...............................TEQEFlDNYWNKYH..QLNKSDHEEFLNSLSGLNKLVA-d..................
C5DDV0_LACTC/232-296             ...t-TNSTI.LHRMESDRERHKKSKEHMWFTER--.......DfML...............................DPREF.DLLWGSLD..G----MSKNDFADVRDINNIAQ-n..................
F2S8P6_TRIT1/172-237             ...v-DRKQI.EQRVEEDRERNKRLRENMWAVPPHD.......-.--...............................-MKEF.EKMWDEVS..DVGDDDYLQAAEEAEERRRTAE-a..................
F4RIT2_MELLP/198-240             ...f-SKRDI.LDRIDDDRERHKRLRERIWVLPIPP.......-.--...............................-----.--------..-----------------------tsslsirpgpsn.......
B9WCX2_CANDC/211-284             ....LSKRHI.LVRMEDDREAHKRSKENFWVVNRDKd....kgN.YI...............................TEDEFvDHYWNKFQ..PLTDQENKEFLNSLQELNGIVE-n..................
E3KJD5_PUCGT/195-244             ...f-SKKEI.LDRIDDDRERHKRLRERIWVLPIPS......iA.T-...............................-----.--------..-----------------------lspkptanahhpatty...
C4R1L6_PICPG/193-258             ....LSEQQI.LARMEADRERHKRAKEKLWMVTRES.......Y.SL...............................SFNEF.ENIDDRFS..S----LQDEDYKELRELKRLVN-k..................
C0NDA5_AJECG/177-242             ....VDKRQI.EQRIEEDRERNKRLRESMWAVPGND.......-.--...............................-ADEF.DKMWDEVS..DLGEDDYLAAEEEAMERKRIAEE...................
B6HHC9_PENCW/167-232             ....LDKKQI.EQRIEEDRERNKRQRESMWAMTGSD.......-.--...............................-RDEY.NQMWEELS..PTGEDDFIRSREEALERAECVR-k..................
B0D9N2_LACBS/209-288             ....LSRSDV.FKRIEEDRERHKRLRERRWVQPVFKa....qgQpGLvsf.........................lddEDVEF.ENEWETTS..DWNEDDDDAVAEEVRMCFSAEE-r..................
Q7RYU9_NEUCR/236-299             ....LDKKQV.EQRIEEDRERHKRLRENIWAVPS--.......-.--...............................-GDEL.DRLLEETS..ELGDDDMRAIWEEQEEWERSLQ-a..................
E7LYJ3_YEASV/221-292             .ptn---ANIlLHRMEADRELHKRSKETSWYIERPS.......NdIL...............................DESEF.KSLWTHFE..TTDSGFDKDDYKNIKALNDIAKA...................
A1C6P7_ASPCL/173-238             ....VDKRQI.EQRIEEDRERNKRLRESMWTVSGDD.......-.--...............................-GDEH.GKFWDEVS..DIGEDDFLGAQEELMERNQMVS-a..................
C8ZE91_YEAS8/221-292             .ptn---ANIlLHRMEADRELHKRSKETSWYIERPS.......NdIL...............................DESEF.KSLWTHFE..TTDSGFDKDDYKNIKALNDIAKA...................
E3RGG4_PYRTT/172-237             ...m-GKREI.EQRIEEDRERHKRLRESIWAVNGDG.......-.--...............................-YEEL.ERLWEEAS..DIGEDDYVTAREDAEERRRVI--af.................
F0UJU6_AJEC8/177-242             ....VDKRQI.EQRIEEDRERNKRLRESMWAVPGND.......-.--...............................-ADEF.DKMWDEVS..DLGEDDYLAAEEEAMERKRIAEE...................
B8NGF7_ASPFN/169-234             ....VDKRQI.EQRIEEDRERNKRLRESMWTVSGDD.......-.--...............................-GDEH.GKFWDETS..DIGEDDFLAANEEFIERRQMV--ga.................
F2QS45_PICP7/193-258             ....LSEQQI.LARMEADRERHKRAKEKLWMVTRES.......Y.SL...............................SFNEF.ENIDDRFS..S----LQDEDYKELRELKRLVN-k..................
G3BCQ9_CANTC/225-297             ....LSRKQI.LSRMEDDRETHKRSKENLWVVNRPK......eVpYV...............................TEHEFqQYYWNRYD..SLSDKDEKALLETLDDFNTVV--ma.................
C5JSH2_AJEDS/177-242             ....VDKRQI.EQRIEEDRERNKRLRESMWAVPGND.......-.--...............................-ADEL.DKMWDEVS..DLGEDDYLAAEEEAMERKRIAEE...................
F8NQE9_SERL9/179-270             ....LSRGEI.FKRIEEDRERHKRLRERRWVQPVSHtp...fsH.-Tqhlaaflplt...........ddqdgaeeltLDIEF.ENEWDATS..DWNEDDVEAATEESELCF-----strd...............
Q6FP45_CANGA/276-345             .nnv---SNI.LHRMENDRERHKRQKENNWVVERVS.......QsML...............................DENEF.KAAWNSIT..SLP-SLSRSDQKDIRQLHTIAR-g..................
B0XSN6_ASPFC/173-238             ....VDKRQI.EQRIEEDRERNKRLRESMWTVSGDD.......-.--...............................-GDEH.GKFWDEVS..DIGEDDFLGAQEELMERNQMVA-a..................
C5GDX3_AJEDR/177-242             ....VDKRQI.EQRIEEDRERNKRLRESMWAVPGND.......-.--...............................-ADEL.DKMWDEVS..DLGEDDYLAAEEEAMERKRIAEE...................
E5A0V7_LEPMJ/165-230             ....MDKRQI.EHRIEEDRERHKRLRESIWAVPGEK.......-.--...............................-EEEM.ERLWEEAS..EVGEDDVVMGREDREERRQAVA-f..................
F2Q3P9_TRIEC/172-237             ...v-DRKQI.EQRVEEDRERNKRLRENMWAVPPHD.......-.--...............................-MKEF.EKMWDEVS..DVGDDDYLQAAEEAEERRRTAE-a..................
G2QDU9_THIHA/182-247             ....LDKKQI.EQRIEEDRERHKRQRENIWAVPPGK.......-.--...............................-NAEM.EKLWEETS..DLGEDDHRMGEEEWAEWKA----efea...............
G8ZNJ7_TORDC/216-284             ...s-SSSTI.LHRMENDREKHKRLKENNWVLERPS......iS.IV...............................DPQEF.RSMWENEP..Y--NTLTKQDYKNIKDLNRIAQQ...................
C4JXE8_UNCRE/121-186             ....VDKRQI.EQRIEEDRERNKRLRENMWAVPPSD.......-.--...............................-MKEF.EMMWEDVS..DIGEDDYLQAAEEAEERRRAGE-a..................
A5DY84_LODEL/218-292             ....LSKRQI.IARMEDERESHKRSKENIWCVNRNVg....ssSrFV...............................SEDEFfENYWTKCQ..PLSKAEDHEFVRNLQELNEMA--lk.................
F8ML44_NEUT8/230-293             ....LDKKQV.EQRIEEDRERHKRLRENIWAVPS--.......-.--...............................-GEEM.DRLLEETS..ELGDDDMRAIWEEQEEWERSLQ-a..................
E4UMM0_ARTGP/172-237             ...v-DRKQI.EQRVEEDRERNKRLRENMWAVPPHD.......-.--...............................-MKEF.EKMWDEVS..DVGEDDYLQAAEEAEERRRTAE-a..................
C5E0M7_ZYGRC/202-270             ...p-STQTI.IHRMESDREKHKRLKENIWVLPRPH......aS.IL...............................NEFEF.RTLWESTP..Q--EGLTKGDYRNMSDMNRIAHA...................
A6ZLV2_YEAS7/221-292             .ptn---ANIlLHRMEADRELHKRSKETSWYIERPS.......NdIL...............................DESEF.KSLWTHFE..TTDSGFDKDDYKNIKALNDIAKA...................
I1BWB2_RHIO9/153-216             ...f-SKQDI.LRRMEEDRERHKRIKEEIWIRPPEE.......-.-S...............................KNAEF.EDFWNSID..KLNPEVD----------------yeqmmlqnrqrl.......
F7WB08_SORMK/232-285             ....LDKKQV.EQRIEEDRERHKRLRENIWAVPS--.......-.--...............................-REEM.ERLLDETS..ELGEDDMRGD-------------vgg................
C1GNM2_PARBA/176-241             ....VDKRQI.EQRIEEDRERNKRLRESMWAVPGND.......-.--...............................-ADEF.DKMWDEVS..DLGEDDYLAAEEEAMERKRIAEE...................
C6HK49_AJECH/177-242             ....VDKRQI.EQRIEEDRERNKRLRESMWAVPGND.......-.--...............................-ADEF.DKMWDEVS..DLGEDDYLAAEEEAMERKRIAEE...................
F4NU91_BATDJ/167-241             ..qa--KDAI.LRRMEEDRERQKKSREETWLRPILD.......-.TLdga.........................ppdIDPEF.LQAWGKPH..SVTEADISAMKTYRER-------idtsvee............
G4TB04_PIRID/182-221             ...i-SRSQA.MRRIEEDRERHKLLRERRWVQQVDR.......-.--...............................-----.--------..-----------------------sdstqptla..........
Q75E03_ASHGO/241-307             ...t-SASTI.LHRMESDRERHKKSKEHLWFTDRDS.......S.ML...............................ELAEF.DALWQQHR..K---GMTRDDYQDVKQLQRIAQE...................
G9N9Q9_HYPVG/174-239             ....LDKRQV.EQRIEEDRERHKRERERIWAVPKGE.......-.--...............................-DAEM.NKLWEETS..DFGDDDDRLLTEEGDDFT-----kemei..............
#=GC seq_cons                    .....sK+QI..pRlEEDRERHKRhREshWslstss...........................................psEa.cphW-cso..shs--D.htsh--ht-hpphh..t..................
//
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