#=GF ID   Cas_Csx9
#=GF AC   PF09658.5
#=GF DE   CRISPR-associated protein (Cas_Csx9)
#=GF AU   TIGRFAMs, Coggill P
#=GF SE   TIGRFAMs
#=GF GA   25.00 25.00;
#=GF TC   26.30 25.80;
#=GF NC   22.20 21.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF DR   INTERPRO; IPR013488;
#=GF CC   Clusters of short DNA repeats with nonhomologous spacers, which
#=GF CC   are found at regular intervals in the genomes of
#=GF CC   phylogenetically distinct prokaryotic species, comprise a family
#=GF CC   with recognisable features. This family is known as CRISPR
#=GF CC   (short for Clustered, Regularly Interspaced Short Palindromic
#=GF CC   Repeats). A number of protein families appear only in
#=GF CC   association with these repeats and are designated Cas
#=GF CC   (CRISPR-Associated) proteins. This entry describes archaeal
#=GF CC   proteins encoded in cas gene regions.
#=GF SQ   8
#=GS Q9UZX2_PYRAB/23-393  AC Q9UZX2.1
#=GS E8R9X2_DESM0/58-220  AC E8R9X2.1
#=GS O58615_PYRHO/1-377   AC O58615.1
#=GS D3S4T9_METSF/16-391  AC D3S4T9.1
#=GS H3ZK36_THELI/23-399  AC H3ZK36.1
#=GS C7P9K6_METFA/16-391  AC C7P9K6.1
#=GS Q5JGB3_PYRKO/23-399  AC Q5JGB3.1
#=GS F8AED3_PYRYC/23-397  AC F8AED3.1
Q9UZX2_PYRAB/23-393             .......FSWIVMDAGLSPNPNDFADAIENSMDTLKKRAM.MNSS.....RIGKNDRNSYDRVFSKW.....FGVKAPDTYMELFELVINETIKLLRSGKIDPAKSLQSITRNKNGTYLGQAYNGEYAITPAV.IKQPEYYEFQSEFLKPTAGQKAQIYLDPLWFSLLSMGFLTAFAGYIRKRYYLMTKPGIEVYF..........P-DVEEILIDGIIALTDAGISSRARLDAEELYELRIVMKLAEEGRKVPEMTYPIALH-ISLEGQVYTELKTLQLDLKELSNYLATYVKKIENYRVMGVDLKVKLKEG----EKYPLWALVDIAEKELNKGVSGDRELLAYIFVKDLYRAVNSGRKELIEDSIFRLFRQGRGLLEGE..GRASG..ELRKVLRVFMQEDHLEVLI......
E8R9X2_DESM0/58-220             dacatlr------------------EALLDVIDVFESRKN.IDERggycpKLS-SNRNDFDWVGNRIanemgFQIEKDITICDFFVKLIKASAEIVSREPGVVAEELKSIRMDEGDIYLGRDESAQ---YPQLqVFKLEKYKYGKKYLSFT-EFKGQMKISSIWYSILGAGWLLSFSGYLG---------------..........--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..-----..-------------------slllah
O58615_PYRHO/1-377              .......MSWVVMEAGLEPDKEELIEALEGALNSLESRTR.INTS.....KIGRNDRNSFNDVLQAW.....FNRSTPETYGELFELVIRETIKLLKEDKIDPSASLSTIKTDKNGTYLGVVYKEKQAILPAI.LKQPEYYEYQSSFLKPTTARKAQIRMDPLWFSFMALGFFTSFAGFISGKYYLITKPGIEGFW..........PYEVEDIIEHGILPLTSAGASGRISLTTEELYEMKLAMKLAEEEKNIIDEVYPVTLHVISLEGQSYTELKTIQLNLIELNNYITEYVKKIRASKVGSMSLLVELKEGGATVKKYPLWALVDIAEKEVWKGVKGDEEMLAYIFVKDLYRAINSGKKDIIQDSIFRLFRQGRALLEGS..SRGSG..EFRKVMRTFMWEEHLGVLL......
D3S4T9_METSF/16-391             ......l-SRIIVEDVDEIDNSTLAEIFKNYVDSFKEKLKnAGSS.....KLSRNDKESYTKTYQKW.....FNINPPEEYVSLMLDIIEKTINLLEDNKIDAKKSLETINVGKNSVNFGIPYNESYAILPAI.IKQVEYYEFLSEFLTPTTGKKSMINLDPIWFSILAVGFLTCFAGYYGGKYYLMLKNDIERYYlaikcgleeeKYELLDILED-LEILTDINIQRRFSLEVEEVYELLLSMELAK--KKASGRIFPITLYVIELSGNVYLAKNVIELDLRNSLEFMKKYIDRIKNYFMFDTS------D-----AKAPLEELLNLALSELKNPVNEDNENLAYIMVKDLYRAINSGKVEILENTLYLLLRKGHSIMSSK..SKSKSklNLEKIFKNFAKEG------nvisil
H3ZK36_THELI/23-399             .......MSWVVMDAGIEPDEEELADALEGALKSLGSRMK.AHTS.....KMGRNDRSSFDKVLNAW.....FGRSAPETYGELFELVVTETIKLLRDGDIDPSESLSSIKIDKNGTYLGVTYNGEQAILPAI.IKQPEYYERQSGFLSPTTGQKAQIRMDPLWFSFTALGFFTGFAGFIGGKYYLMTKPGIEGFW..........PYEVEDVIRNGLLQLTGAGASGRISLSTEELYEMKLAMKLAEEGRNVVEEVYPVTLHLISLERQVYTELKTTQLNLAGLSEYMTKYMRKIEAISIGGLPLLVELKEGNATVQKYPLWALLDVAEKELWKGVNGDGEMLAYIFVKDLYRAINSGRRELIRDAVFRLFRQGRALLEGS..SRASG..EFRKVMKTFMWQEHLGVLL......
C7P9K6_METFA/16-391             ...lsri----MVEDFDEIDNTTLAEIFKNYVYGFKEKLKnAGSS.....KLSRNDKESYKKTYQNW.....FNTIPPEEYTSLMLDIIEKTINLLEGNKIDAKKSLRAIKVGKNSVDFGIPYNGSYAILPAI.IKQVEYYEFLSEFLTPTTGKKSMINLDPIWFSILAIGFLTCFAGYYGGKYYLMLKNDIERYYlaikygmeeeKYELLEILED-LEILTDINIQKRFSLEVEEIYELLLSMELAK--KKASGKVFPITLYVIELSGNVYLAKNVLELDLRNSLNFMKKYIDRIKNYSMFES------S-----DAKIPLEELLYLALKELKNPINEDNENLAYIMVKDLYRAINSGKVEILENTLYLLLRKGHSILSSKssSKSKL..NLEKTFKSFAKEG------niisil
Q5JGB3_PYRKO/23-399             .......MSWVVMDAGIEPDEEELADTLEGALKSLGSRVK.IHTS.....KMGRNDRSSFDKVLKAW.....FGRSAPETYGELFELVVTETIKLLRDGNIDPGESLSTIKTDKNGTYLGIAYNGEQAILPAI.IKQPEYYERQSGFLSPTTGQKAQIRMDPLWFSFMALGFFTSFAGFIGGKYYLMTKPGIEVFW..........PYEVEEIIEKGILPLTGAGASGRISLSTEELYEMKLAMKLAEEGRDVIEEVYPVTLHLISLEGQVYTELKTTQLNLTGLSEYMEEYVNRIESASMGGLPILVELKAGNATIQKYPLWALVDIAERELWKGVNGDGEMLAYIFVKDLYRAINSGRRELIRDAVFRLFRQGRALLEGS..GRASG..EFRKVMKTFMWQEHLEVLL......
F8AED3_PYRYC/23-397             .......LSWVVIDAGLSPNADDFADALENSMDTLEKRAR.MNSS.....RMSRNDRSSYNKLLSAW.....YGVKAPDTYTELFELAIREAVKLLRSGKLDPAKSLGSIKWDKNGTYLGQPYNGQYAISPAV.VKQPEYYEFQSDFLKPTAGQKAQIYLDPLWLAILSTGFLTAFAGFIDGRYYLMTKPGIEAYF..........P-DIEDIL-DSLLILTNAGIESRARLETEELYELKITMKLAEEKMNVLEEIYPVTLHLISLEGQVYTELKTLQLDLRELSNYLLAYVERIENYMAMGVNLKVKLKEDNIEVERYPLWALVNIAERELRKGIEGDRELLAYILVKDLYRAVNAGRKELIEDSVFRIFRQGRGLLEGT..GKASG..ELRKVLRAFMQEHHLEVLV......
#=GC seq_cons                   .......hSWlVh-AGlEPDpp-LA-ALEsulcoLcpRh+.hsoS.....KluRNDRsSacKVhpsW.....FshpsPETYsELFELlIcETIKLL+csKIDPucSLpoIKhDKNGTYLGlsYNGp.AILPAI.IKQPEYYEaQScFLoPTTGpKAQIplDPLWFSlLAlGFLTuFAGaIGGKYYLMTKPGIEsaa..........PYElE-Ilccull.LTsAGhpuRhSLpsEELYEh+LuMKLAEEt+pl.-clYPlTLHlISLEGQVYTELKTlQLsLppLspYhpcYlc+IcshphhuhslhVcLK-s....pKYPLWALlslAE+ELhKGVsGDpEhLAYIhVKDLYRAINSG++ElIcDolFRLFRQGRuLLEGp..u+uSG..EhRKVh+sFMhEcHLtVLl......
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