GenomeNet

Database: Pfam
Entry: CompInhib_SCIN
LinkDB: CompInhib_SCIN
Original site: CompInhib_SCIN 
#=GF ID   CompInhib_SCIN
#=GF AC   PF11546.5
#=GF DE   Staphylococcal complement inhibitor SCIN 
#=GF AU   Pollington J
#=GF SE   pdb_2qff
#=GF GA   21.30 21.30;
#=GF TC   21.40 142.20;
#=GF NC   20.50 20.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17709514
#=GF RT   Staphylococcal complement inhibitor: structure and active sites. 
#=GF RA   Rooijakkers SH, Milder FJ, Bardoel BW, Ruyken M, van Strijp JA,
#=GF RA   Gros P; 
#=GF RL   J Immunol. 2007;179:2989-2998.
#=GF DR   INTERPRO; IPR021612;
#=GF CC   SCIN is released by Staphylococcus aureus to counteract the host
#=GF CC   immune defense. The protein binds to and inhibits C3 convertases
#=GF CC   on the bacterial surface, reducing phagocytosis and blocking
#=GF CC   downstream effector functions by C3b deposition on its surface
#=GF CC   [1]. An 18 residue stretch 31-48 is crucial for SCIN activity
#=GF CC   [1].
#=GF SQ   4
#=GS B9DLL9_STACT/1-113  AC B9DLL9.1
#=GS SCIN_STAA8/1-114    AC Q2FWV6.1
#=GS Q2G1D4_STAA8/5-111  AC Q2G1D4.1
#=GS Q2FZB7_STAA8/1-116  AC Q2FZB7.1
B9DLL9_STACT/1-113             MNFKQFLLSGLAVALLGSAGASVFS-NQAEAASY....GAYEFRNYDITakENLKNLLDASSYYKaMAKESGATLYQNKLNQAIYFAKKQQDASNDSQVVTAINRLSTVYNEV------fqihl
SCIN_STAA8/1-114               MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSl..pTSNEYQNEKLA..NELKSLLDELNVNE.LATGSLNTYYKRTIKISGLKAMYALKSKDFKKMSEAKYQLQKIYNEIDEALKS.....
Q2G1D4_STAA8/5-111             MKIKTYLVAGIKAALLDTTGIKLASKSET-----....TSHTYQHQALV..DQLHELIANTDLNK.LSYLNLDAFQKRDILAAHYIAKSAIRTKNLDQMTKAKQRLESIYNSISNPLHS.....
Q2FZB7_STAA8/1-116             MKFKKYILTGTLALLLSSTGIATIEGNKADASSLdkylTESQFHDKRIA..EELRTLLNKSNVYA.LAAGSLNPYYKRTIMMNEYRAKAALKKNDFVSMADAKVALEKIYKEIDEIINR.....
#=GC seq_cons                  MKhKpalLuGhhAhLLuSsGlsshstNcApAuo.....Tuppapspcls..-pL+sLLsposl.c.LAttSLssaYKRsIhhutYhAKtAl+spshspMscAK.pLppIYNEIsp.lpp.....
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