GenomeNet

Database: Pfam
Entry: CompInhib_SCIN
LinkDB: CompInhib_SCIN
Original site: CompInhib_SCIN 
#=GF ID   CompInhib_SCIN
#=GF AC   PF11546.6
#=GF DE   Staphylococcal complement inhibitor SCIN 
#=GF AU   Pollington J
#=GF SE   pdb_2qff
#=GF GA   21.30 21.30;
#=GF TC   21.40 23.10;
#=GF NC   20.80 20.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17709514
#=GF RT   Staphylococcal complement inhibitor: structure and active sites. 
#=GF RA   Rooijakkers SH, Milder FJ, Bardoel BW, Ruyken M, van Strijp JA,
#=GF RA   Gros P; 
#=GF RL   J Immunol. 2007;179:2989-2998.
#=GF DR   INTERPRO; IPR021612;
#=GF CC   SCIN is released by Staphylococcus aureus to counteract the host
#=GF CC   immune defense. The protein binds to and inhibits C3 convertases
#=GF CC   on the bacterial surface, reducing phagocytosis and blocking
#=GF CC   downstream effector functions by C3b deposition on its surface
#=GF CC   [1]. An 18 residue stretch 31-48 is crucial for SCIN activity
#=GF CC   [1].
#=GF SQ   6
#=GS B9DLL9_STACT/1-113     AC B9DLL9.1
#=GS SCIN_STAA8/1-114       AC Q2FWV6.1
#=GS Q2G1D4_STAA8/5-111     AC Q2G1D4.1
#=GS Q2FZB7_STAA8/1-116     AC Q2FZB7.1
#=GS A0A0N4Y4T3_NIPBR/8-92  AC A0A0N4Y4T3.1
#=GS D4YV90_9LACO/1-81      AC D4YV90.1
B9DLL9_STACT/1-113                ..........MNFKQFLLSGLAVALLGSAGASVFS-.NQAEAASY....GAYEFRNYDITakENLKNLLDASSYYKaMAKESGATLYQNKLNQA...IYFAKKQQDASNDSQVVTAINRLSTVYNEV------fqihl................
SCIN_STAA8/1-114                  ..........MKIRKSILAGTLAIVLASPLVTNLDK.NEAQASTSl..pTSNEYQNEKLA..NELKSLLDELNVNE.LATGSLNTYYKRTIKIS...GLKAMYALKSKDFKKMSEAKYQLQKIYNEIDEALKS.....................
Q2G1D4_STAA8/5-111                ..........MKIKTYLVAGIKAALLDTTGIKLASK.SET-----....TSHTYQHQALV..DQLHELIANTDLNK.LSYLNLDAFQKRDILAA...HYIAKSAIRTKNLDQMTKAKQRLESIYNSISNPLHS.....................
Q2FZB7_STAA8/1-116                ..........MKFKKYILTGTLALLLSSTGIATIEG.NKADASSLdkylTESQFHDKRIA..EELRTLLNKSNVYA.LAAGSLNPYYKRTIMMN...EYRAKAALKKNDFVSMADAKVALEKIYKEIDEIINR.....................
A0A0N4Y4T3_NIPBR/8-92             lllalattcy--------------------------.----ATCK....TLETYNRDNIP..EELKNVLNRCAFFK.VAMRKGHWFYIRKISYNgrtMYIAKVIDRKGE------------------------dafmeipedlstyw.......
D4YV90_9LACO/1-81                 ..........MKIRRFFLTLTASVLLASSGVAIISApTEVQAANY....SSSEAKKVKAF..QAAYHQLDTTNYTQ.-----------------...------------------------------------tnlytissnfaacsrphrlqa
#=GC seq_cons                     ..........MKh+palLsGhhuhLLuSsGlshhst.scspAush....Tuppapcpcls..-pL+sLLsposhhc.lAhtshssaYpRpI.hs...hYhAKht.+pps..phspAh.tLpplYppl...........................
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