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Database: Pfam
Entry: CompInhib_SCIN
LinkDB: CompInhib_SCIN
Original site: CompInhib_SCIN 
#=GF ID   CompInhib_SCIN
#=GF AC   PF11546.7
#=GF DE   Staphylococcal complement inhibitor SCIN 
#=GF AU   Pollington J
#=GF SE   pdb_2qff
#=GF GA   21.30 21.30;
#=GF TC   21.40 23.10;
#=GF NC   20.90 20.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17709514
#=GF RT   Staphylococcal complement inhibitor: structure and active sites. 
#=GF RA   Rooijakkers SH, Milder FJ, Bardoel BW, Ruyken M, van Strijp JA,
#=GF RA   Gros P; 
#=GF RL   J Immunol. 2007;179:2989-2998.
#=GF DR   INTERPRO; IPR021612;
#=GF CC   SCIN is released by Staphylococcus aureus to counteract the host
#=GF CC   immune defense. The protein binds to and inhibits C3 convertases
#=GF CC   on the bacterial surface, reducing phagocytosis and blocking
#=GF CC   downstream effector functions by C3b deposition on its surface
#=GF CC   [1]. An 18 residue stretch 31-48 is crucial for SCIN activity
#=GF CC   [1].
#=GF SQ   7
#=GS A0A0A8HS07_STAHY/1-115  AC A0A0A8HS07.1
#=GS B9DLL9_STACT/1-113      AC B9DLL9.1
#=GS SCIN_STAA8/1-114        AC Q2FWV6.1
#=GS Q2G1D4_STAA8/5-111      AC Q2G1D4.1
#=GS Q2FZB7_STAA8/1-116      AC Q2FZB7.1
#=GS A0A0N4Y4T3_NIPBR/8-92   AC A0A0N4Y4T3.1
#=GS D4YV90_9LACO/1-81       AC D4YV90.1
A0A0A8HS07_STAHY/1-115             ..........MNMKSLIITGFAATMLATSAFSTVGA.GDAQANTEakvnTTNEYLNKQME..KELKELYDKINVKL.LSSVSQPTYFKRELSAA...KFKARIALKKKNYSLMAQSKGELERLYDQLA-----rtmy.................
B9DLL9_STACT/1-113                 ..........MNFKQFLLSGLAVALLGSAGASVFS-.NQAEAASY....GAYEFRNYDITakENLKNLLDASSYYKaMAKESGATLYQNKLNQA...IYFAKKQQDASNDSQVVTAINRLSTVYNEV------fqihl................
SCIN_STAA8/1-114                   ..........MKIRKSILAGTLAIVLASPLVTNLDK.NEAQASTSl..pTSNEYQNEKLA..NELKSLLDELNVNE.LATGSLNTYYKRTIKIS...GLKAMYALKSKDFKKMSEAKYQLQKIYNEIDEALKS.....................
Q2G1D4_STAA8/5-111                 ..........MKIKTYLVAGIKAALLDTTGIKLASK.SET-----....TSHTYQHQALV..DQLHELIANTDLNK.LSYLNLDAFQKRDILAA...HYIAKSAIRTKNLDQMTKAKQRLESIYNSISNPLHS.....................
Q2FZB7_STAA8/1-116                 ..........MKFKKYILTGTLALLLSSTGIATIEG.NKADASSLdkylTESQFHDKRIA..EELRTLLNKSNVYA.LAAGSLNPYYKRTIMMN...EYRAKAALKKNDFVSMADAKVALEKIYKEIDEIINR.....................
A0A0N4Y4T3_NIPBR/8-92              lllalattcy--------------------------.----ATCK....TLETYNRDNIP..EELKNVLNRCAFFK.VAMRKGHWFYIRKISYNgrtMYIAKVIDRKGE------------------------dafmeipedlstyw.......
D4YV90_9LACO/1-81                  ..........MKIRRFFLTLTASVLLASSGVAIISApTEVQAANY....SSSEAKKVKAF..QAAYHQLDTTNYTQ.-----------------...------------------------------------tnlytissnfaacsrphrlqa
#=GC seq_cons                      ..........Mph+phllsGhhuhlLuosuhshhst.scspAss.....Tsppappppls..cpL+pLLspsshhp.luhhshssaapRpl.hs...hahA+ht.+pps...hspuh.tLpplYppl...........................
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