GenomeNet

Database: Pfam
Entry: DFF40
LinkDB: DFF40
Original site: DFF40 
#=GF ID   DFF40
#=GF AC   PF09230.7
#=GF DE   DNA fragmentation factor 40 kDa
#=GF AU   Sammut SJ
#=GF SE   pdb_1v0d
#=GF GA   25.00 25.00;
#=GF TC   48.20 27.40;
#=GF NC   24.30 23.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   DFFB
#=GF RN   [1]
#=GF RM   15149602
#=GF RT   Structural mechanism for inactivation and activation of
#=GF RT   CAD/DFF40 in the apoptotic pathway. 
#=GF RA   Woo EJ, Kim YG, Kim MS, Han WD, Shin S, Robinson H, Park SY, Oh
#=GF RA   BH; 
#=GF RL   Mol Cell. 2004;14:531-539.
#=GF DR   INTERPRO; IPR015311;
#=GF DR   SCOP; 1v0d; fa;
#=GF CC   Members of this family of eukaryotic apoptotic proteins induce
#=GF CC   DNA fragmentation and chromatin condensation during apoptosis
#=GF CC   [1].
#=GF SQ   97
#=GS I3LN88_PIG/103-191        AC I3LN88.1
#=GS M3ZSJ8_XIPMA/102-326      AC M3ZSJ8.1
#=GS H2V7W9_TAKRU/103-327      AC H2V7W9.1
#=GS B0WHX2_CULQU/111-423      AC B0WHX2.1
#=GS E9GG77_DAPPU/121-330      AC E9GG77.1
#=GS DFFB_HUMAN/100-323        AC O76075.1
#=GS H2N9C7_PONAB/169-266      AC H2N9C7.1
#=GS F4WNU5_ACREC/103-410      AC F4WNU5.1
#=GS C3YR00_BRAFL/99-325       AC C3YR00.1
#=GS Q7Q1Q3_ANOGA/113-405      AC Q7Q1Q3.4
#=GS G5CBI1_HETGA/69-238       AC G5CBI1.1
#=GS G3ILD6_CRIGR/103-235      AC G3ILD6.1
#=GS A0A067QYQ3_ZOONE/95-331   AC A0A067QYQ3.1
#=GS K1P4N7_CRAGI/109-334      AC K1P4N7.1
#=GS H2PXW1_PANTR/100-150      AC H2PXW1.1
#=GS DFFB_BOVIN/103-326        AC Q58CZ0.1
#=GS Q29KJ1_DROPS/153-440      AC Q29KJ1.2
#=GS G1R9M5_NOMLE/100-227      AC G1R9M5.1
#=GS B4Q4R0_DROSI/151-435      AC B4Q4R0.1
#=GS H3D014_TETNG/100-323      AC H3D014.1
#=GS B4DZS0_HUMAN/124-347      AC B4DZS0.1
#=GS B4M987_DROVI/148-432      AC B4M987.1
#=GS H2MYH3_ORYLA/98-199       AC H2MYH3.1
#=GS G3ILD5_CRIGR/1-90         AC G3ILD5.1
#=GS H3C5P7_TETNG/101-324      AC H3C5P7.1
#=GS E2BEW9_HARSA/1-84         AC E2BEW9.1
#=GS I3JHL3_ORENI/102-326      AC I3JHL3.1
#=GS G3RC98_GORGO/124-347      AC G3RC98.1
#=GS A7RES0_NEMVE/56-282       AC A7RES0.1
#=GS F6VS33_HORSE/63-285       AC F6VS33.1
#=GS I3M3Q6_SPETR/103-326      AC I3M3Q6.1
#=GS B3MV75_DROAN/151-436      AC B3MV75.1
#=GS W5LKE6_ASTMX/107-333      AC W5LKE6.1
#=GS F7DWB0_ORNAN/1-179        AC F7DWB0.1
#=GS M3Y775_MUSPF/63-286       AC M3Y775.1
#=GS A0A091DI54_FUKDA/69-292   AC A0A091DI54.1
#=GS G7NTB1_MACFA/100-172      AC G7NTB1.1
#=GS U3I6P3_ANAPL/56-279       AC U3I6P3.1
#=GS B4JZC1_DROGR/136-424      AC B4JZC1.1
#=GS U3K4V3_FICAL/17-241       AC U3K4V3.1
#=GS B4IEI7_DROSE/151-435      AC B4IEI7.1
#=GS H2PXW1_PANTR/143-296      AC H2PXW1.1
#=GS F7F2F7_MONDO/103-326      AC F7F2F7.2
#=GS J9KG38_ACYPI/96-331       AC J9KG38.2
#=GS Q9V3H0_DROME/151-435      AC Q9V3H0.1
#=GS E2R6H2_CANFA/103-326      AC E2R6H2.1
#=GS E0VAJ8_PEDHC/96-319       AC E0VAJ8.1
#=GS L5MJY3_MYODS/92-163       AC L5MJY3.1
#=GS J3KT26_HUMAN/1-63         AC J3KT26.1
#=GS G3W2P1_SARHA/63-286       AC G3W2P1.1
#=GS Q17BG6_AEDAE/110-414      AC Q17BG6.1
#=GS H0YWX9_TAEGU/100-324      AC H0YWX9.1
#=GS H3BIK5_LATCH/105-327      AC H3BIK5.1
#=GS A0A096MXP6_PAPAN/100-323  AC A0A096MXP6.1
#=GS A0A087X8J9_POEFO/102-326  AC A0A087X8J9.1
#=GS F7IAB5_CALJA/124-347      AC F7IAB5.1
#=GS F1N2E0_BOVIN/103-326      AC F1N2E0.1
#=GS T1GHI0_MEGSC/21-279       AC T1GHI0.1
#=GS T1HD95_RHOPR/69-208       AC T1HD95.1
#=GS K7J7X5_NASVI/118-445      AC K7J7X5.1
#=GS U4U402_DENPD/143-376      AC U4U402.1
#=GS B7PNY7_IXOSC/49-277       AC B7PNY7.1
#=GS E9ICJ0_SOLIN/1-205        AC E9ICJ0.1
#=GS D6WW09_TRICA/100-329      AC D6WW09.1
#=GS F7I365_CALJA/100-323      AC F7I365.1
#=GS DFFB_RAT/103-324          AC Q99N34.1
#=GS L5MJY3_MYODS/161-293      AC L5MJY3.1
#=GS L5KJ86_PTEAL/103-326      AC L5KJ86.1
#=GS F7EHI4_XENTR/107-330      AC F7EHI4.1
#=GS B4MWI4_DROWI/149-435      AC B4MWI4.1
#=GS H9GDK6_ANOCA/98-319       AC H9GDK6.2
#=GS H0X4M1_OTOGA/103-326      AC H0X4M1.1
#=GS M3WFF9_FELCA/103-326      AC M3WFF9.1
#=GS G1SEV9_RABIT/1-180        AC G1SEV9.1
#=GS F7EHJ0_XENTR/107-330      AC F7EHJ0.1
#=GS W5MFN3_LEPOC/105-329      AC W5MFN3.1
#=GS F1P3V6_CHICK/74-298       AC F1P3V6.2
#=GS B4KK42_DROMO/145-429      AC B4KK42.1
#=GS G1MS59_MELGA/22-246       AC G1MS59.2
#=GS G1Q3M5_MYOLU/1-175        AC G1Q3M5.1
#=GS Q1L9C6_DANRE/102-326      AC Q1L9C6.1
#=GS G3TI43_LOXAF/103-326      AC G3TI43.1
#=GS DFFB_MOUSE/103-324        AC O54788.1
#=GS DFFB_MOUSE/103-324        DR PDB; 1V0D A; 103-324;
#=GS V4B759_LOTGI/1-79         AC V4B759.1
#=GS G6DK22_DANPL/100-352      AC G6DK22.1
#=GS L8YI78_TUPCH/695-918      AC L8YI78.1
#=GS H2N9C7_PONAB/100-171      AC H2N9C7.1
#=GS G3NPN2_GASAC/103-327      AC G3NPN2.1
#=GS W5JGP2_ANODA/113-410      AC W5JGP2.1
#=GS E2AMM4_CAMFO/32-338       AC E2AMM4.1
#=GS H0UTL9_CAVPO/103-326      AC H0UTL9.1
#=GS G1LRH4_AILME/103-326      AC G1LRH4.1
#=GS F6WIJ2_MACMU/100-172      AC F6WIJ2.1
#=GS W5PYX3_SHEEP/103-326      AC W5PYX3.1
#=GS A0A088ARL5_APIME/135-431  AC A0A088ARL5.1
#=GS W4WPJ7_ATTCE/148-455      AC W4WPJ7.1
#=GS G5CBI1_HETGA/299-368      AC G5CBI1.1
I3LN88_PIG/103-191                   ......................................i-QAARQLLS...dERAPLRQKLLADLLGT...VS.E......NIAA...ETRAEDPPWFEGLEARF.RSKSAYLRYSCESRIRSYLREVRLHRR--......---------------------------------............................................................................................................--.-.-----------------...-------......--------------------------.--------------................................-------------------------------------......------------qlcqaglgsqlg
M3ZSJ8_XIPMA/102-326                 ......................................i-EAAKGLLS...dEKSFKRRKVLTDLLQN...LE.D......RSDL...ESREEDEDWFTGVDVRF.KTKSAYMKYNCESRIRGYMKEVDNATNGT......QKAKVKEEFLKTSKCLVEMLKNDKYNGKYFDRT............................................................................................................EK.E.SGRLCTKEGWFTCQGSF...EQKLCQS......LHSINPYGSRESRIVFSTWNLDHRIE.KKRTIIPALLEAL-................................-QTHKTADINLNYFYQMLFTRENLKLVHIVCHKKGAH......-NLMCDTNKMF-r...........
H2V7W9_TAKRU/103-327                 ......................................i-EAAKRLLP...dEPTSKRRKIMSDLLQN...LE.D......RSEL...ETRDEDEDWFKGVAPRF.KTKSAYMRVNCESRIRGYTKELLEASKSI......EKAKVRAEFLKASKALVEMLKEAKYNGCYFDRT............................................................................................................GD.E.DHRLCTQEGWFTCQGAF...DQDTCLS......LHSINPYSSQESRIIFSTWNLDHRIE.KRRTVIPALLRAL-................................-ENHRSSEVNLDYFYRLLFTTENLKLVHIVCHKKEAH......-NLPCDSRKVF-r...........
B0WHX2_CULQU/111-423                 .....................................gs--LAKQFVS....NNQTQIARMLEEAQRA...QD.E......RTAK...SRRSEHAEWFEGFDSRAgQTKEEIMQRRGQDRIRGYFYKTKDELTKCai..yrGNVMAKELIDEMLELFRHLLIGFDYFSAIFDRShparlpdnaevsdlvvgsgertvaaaaaasp.............................................dgqedevdaqrivpkrmklaiketlekdgnaiER.Y.RVALCNSRGEFRCMGLW...NERKCKY.....gAHVINPYASRENMILFQVWNLDHQVE.ISRSVLPSIVQNVArvvake....................adavcrVHNRRGKKLSVITYFIELFTLGNLKLVHIVCHDKSIHdm.isrGAIICEKCAEYK............
E9GG77_DAPPU/121-330                 .....................................ae--EIVKFIE....DNKDEKLKLTWQYVSK...LP.S.....tKSHL...SSISEHPEWFSGCNKLV.TTKEEYFRKCAQGRIRSYLRDARNRLSNN......------NLSLCPIDKFKSCLEKQKYFACYFDRK............................................................................................................DK.S.QDKLCDSKGQFQCQGQY...NKTICES......SHQINPYDNAESRVLFSTWNLDHVIE.RVK-ILSDLCLKI-................................---RCNNEFDHLKYFDLLFSKKNLKLVHKNCHVIGPH......T-----------ecqi........
DFFB_HUMAN/100-323                   ......................................i-QAAQQLLC...dEQAPQRQRLLADLLHN...VS.Q......NIAA...ETRAEDPPWFEGLESRF.QSKSGYLRYSCESRIRSYLREVSSYPSTV......-GAEAQEEFLRVLGSMCQRLRSMQYNGSYFDRG............................................................................................................AK.G.GSRLCTPEGWFSCQGPF...DMDSCLS......RHSINPYSNRESRILFSTWNLDHIIE.KKRTIIPTLVEAI-................................-KEQDGREVDWEYFYGLLFTSENLKLVHIVCHKKTTH......-KLNCDPSRIYK............
H2N9C7_PONAB/169-266                 ......................................r---------....----------------...--.-......----...-----------------.-----------------------------......---------------------------------............................................................................................................--.-.-------------EGPF...DMDSCLS......RHSINPYSNRESRILFSTWNLDHIIE.KKRTIIPTLVEAI-................................-KEQDGREVDWEYFYGLLFTSENLKLVHIVCHKKTTH......-KLNCDPSRIYK............
F4WNU5_ACREC/103-410                 ......................................g-DRVTQFLT....ENLKAKVALLNKVLNK...DD.S......KTAL...STREEHSEWFENLETNC.MTKEAYMHRRCQDRIRTYLYKTIEQIKCSdv..fmNDYKARQQLLHTIAFFKLQLKQDHYFGYYFDRSraesdtksdsdetdygrcyehcpcnfgrindetylrqwylrlpq....................ssdtnstadsdkidetdarkclaseknvktanddsescpyrvklRE.K.QIAICNKKGEFKCEGRW...NTDGCPYg....dRHKINPYRSKEDLVLFSTWNLDHKIE.RSRTLIPKLLQIS-................................-RQDTINEEDIYDCYDNLFTVKNLRLVHIVCHDKGSH......------------k...........
C3YR00_BRAFL/99-325                  ......................................t-ENLEDMIA...kESSPERVHALNLYLQS...IP.D......NIDA...ETREEDPDWFEGLDKRY.KTKSQVMAYSAQGRIRGYFSTTKEFISNL......EDPVTKLILKRVLESFRPRLKNNGYHGDYFRRT............................................................................................................AK.P.KKRLCTQAGWFVCHGPY...NTKTCQE......KHMINPYSSRQKRAAFSTWNLDHRIE.KSRSILPSMQQAA-................................MSCPKGKQLNWEYFYELLFTTDNLKLVEISCHKKDAH......KGYDCDEKKYY-t...........
Q7Q1Q3_ANOGA/113-405                 ......................................g-ELAQQFVS....NNQPEISKILFNAQRG...RD.D......LIQR...SAREEHAEWFEGKKKAA.VTKEEVMKRRGQDRIRGYFYKTKDELTKCam..yrGSPMARELIDEMLELFRQLLVGFDYFSCMFDRScqrrmelkpdtedggdepdaq..................................................................rippkrlkllvqsslgrgcriEP.Y.NVALCSERGDFRCMGVW...KDERCRY.....aSHRINPYASRENLILFQVWNLDHQVE.ISRSVLPSILDNVErmvssad..................ggapmckLHRRKGKNLSVITYFLELFTLSNLKLVHIVCHDKTVHel.isnGTIICDRCEEYK............
G5CBI1_HETGA/69-238                  ......................................l-QVARQLLE...dEQAPLRQKLLADLLQS...AS.Q......NIAA...ETRAQDPPWFEGVESRF.RNKSGYLRYSCESRIRGYLREVSTYASGV......-AVGAREEYLRVLDSMCQKLKAAQYHGSYFDRE............................................................................................................AE.A.GGRLCTPEGWFSCQGPF...DLENCAS......KHSINPYSNRESRILFSTWNLDHM--.--------------................................-------------------------------------......------------pgvkvqre....
G3ILD6_CRIGR/103-235                 ......................................i-RAARQLLS...dEQAPRRQKLLADLLHH...VS.Q......NITA...ETREQDPSWFEGLESRF.RNKSGYLRYNCESRIRGYLREVSAYTSVV......-DAAARGEFERVLSSMSQKLKSVKYNGSYFDRG............................................................................................................AE.A.SSRLCTPEGWFSCQVRF...-------......--------------------------.--------------................................-------------------------------------......------------vd..........
A0A067QYQ3_ZOONE/95-331              ......................................g-KEVQKFFT....QNVKEKVMNLAKLLNK...AS.Hi....qNVQL...SKKADDPDWFEGTESRS.ATKEEFMARRSQDRIRGYMYKTQDDLKKSea..yqNDQICQKKLTEALQEMNLRLKANKYFRDYFDRS............................................................................................................-A.V.SDRLCDSAGTFQCKGRW...DLPRCRYkgvvtnHHMINPYASRESRIVFSTWNFDHVVE.RSRSIVPAFLEAAK................................LASNNNTAINTNYFYRLLFTTDNLKLVHIVCHDKGAH......-NVQCDPCKF--tv..........
K1P4N7_CRAGI/109-334                 .....................................as--QIRDLLI...tENAPEKIHIISQYLEL...LE.T......NTSS...EKRQDHEDWFEGLNKKY.KTKSDVMRHSAQTRIRSYYMTAKEQIERE......ADKEYKQDLLDLLEEGFQKLKKSDFHSSYFDRT............................................................................................................AS.E.KQRMCDKQGWFRCEGPF...DMDNCDR......FHTINPYASKGYRQLFGLWNLDHIIE.KSREVIPRFIEAA-................................RSKQKHQDLNIDLLYKLLFTRENLKLVQVGCHKKAAR......E-----------sgkitwndfc..
H2PXW1_PANTR/100-150                 ......................................i-QAAQQLLC...dEQAPQRQRLLADLLHN...VS.Q......NIAA...ETRAEDPPWFE------.-----------------------------......---------------------------------............................................................................................................--.-.-----------------...-------......--------------------------.--------------................................-------------------------------------......------------vssypst.....
DFFB_BOVIN/103-326                   ......................................i-QAARQLLW...dERAPLRQKLLADLLGT...VS.E......NIAA...ETRAEDPPWFEGLESRF.RSKSGYLRYSCESRIRSYLREVTSGASLV......-GAEAREEYLRLVGSMQQKLQAAQYNSSYFDRG............................................................................................................AK.A.GRRLCTPEGWFSCQGPF...DVDDCTS......RHSINPYSNRESRVLFSTWNLDHVIE.KKRVVVPALAAAV-................................-HDAEGREVDWEYFYRLLFTLENLKLVHIACHKKTTH......-KLHCDPSRVY-c...........
Q29KJ1_DROPS/153-440                 ......................................p-EKFRRMIS....DYEHQKQRLVLDNSKA...H-.-......---L...SLKDEHVEWFEGGEERF.HSKEEAMAVRAQTRVRGYYYKAKEELTRNpl..yrQNPKARQVINSVLEQFRYLLIGCDYFSMMFNRKceqkhdflqqhrqqtgdeepda................................................................gslpskrlrqlikeytkqhsilDD.W.SVSLCTDLGDFYCQGAYs.dNGNCCSL......QHTINPYASRENLILFQVWNLDHQIE.LSRTILPAMVANVEelvtk.....................pqlkcsFHNKRVVDISVLEYFLEIFSLKNLKLVHVVCHEKVQRsn.rsnGRLLCPDCHEYR............
G1R9M5_NOMLE/100-227                 ..........................pqdtksclsepae---------....---CQGLRLLDSQREK...SK.S......NVHV...ATSPATPPFSTGPSERQqSTKSSYLGFPKLSNVP-WFLQVSSYPSTV......-GAEAQEEFLRVLGSMCQKLRSVQYNGSYFDRG............................................................................................................AK.G.GGRLCTPEGWFSCE---...-------......--------------------------.--------------................................-------------------------------------......------------............
B4Q4R0_DROSI/151-435                 ......................................p-EKFRRMIT....EYEHQKQRRVLDNSKA...H-.-......---L...SLKAEHVEWFTGGEERF.HSKEEAMATRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINSVLEKFRYLLIGCDFFSMMFDRNckqkheflqqhlgdeetdag...................................................................ripskrlrqvikeytkencilDE.W.STSLCSDLGDFYCQGSYs.eNGNSCSK......QHTINPYASRENLILFQVWNLDHQIE.LCRTILPALVANVEelvsh.....................pqtkcsLHKKQVVDISVLEYFLEIFSLKNLKLVHIVCHEKAQRsn.rsnGRLLCSHCHEYR............
H3D014_TETNG/100-323                 ......................................v-KAAEDLLR...dERSPKSRKVLSDLLLN...LE.D......RSEL...ETRDQDADWFRGVGPWF.KTKSDYMKHSCRSRIRGYTREVKSS-KSI......KKAKVRKEFQKASESLEEMLKEAKYNGCYFDRS............................................................................................................AE.E.EERLCTPEGWFTCQGSF...DQEACSF......FHSINPYSSYESRIVFSTWNLDHRIE.KRRTVIPTLLGAV-................................-ERHGQARVDLGYFYQLLFTTRNLKLVHIVCHKKEAH......-NLACDGRKL--lr..........
B4DZS0_HUMAN/124-347                 ......................................i-QAAQQLLC...dEQAPQRQRLLADLLHN...VS.Q......NIAA...ETRAEDPPWFEGLESRF.QSKSGYLRYSCESRIRSYLREVSSYPSTV......-GAEAQEEFLRVLGSMCQRLRSMQYNGSYFDRG............................................................................................................AK.G.GSRLCTPEGWFSCQGPF...DMDSCLS......RHSINPYSNRESRILFSTWNLDHIIE.KKRTIIPTLVEAI-................................-KEQDGREVDWEYFYGLLFTSENLKLVHIVCHKKTTH......-KLNCDPSRIYK............
B4M987_DROVI/148-432                 ......................................p-DKFRRMIT....EYEQQKQRRALDNTKA...H-.-......---L...SLKAEHLEWFEGSEERF.QSKEEAMAMRAQTRVRGYYYKTKEELTRNql..yrQNAKARQVINSVLDQFRYLLIGCDYFSMIFNRKcqlkhemlqqqvgveqpdag...................................................................nvpnkrlrqiikdytsrhailDE.W.SVSLCTDLGDFYCQGAYs.dNGNNCSL......RHTINPYASRENLILFQVWNLDHQIE.LCRSILPALVANVKelvsq.....................pqkkcaLHNKRIVDISVLEYFLEIFSLKNLKLVHIVCHEKVQRtn.hsnGRLLCGDCHEYR............
H2MYH3_ORYLA/98-199                  ......................................i-QAAKWLLC...eEESFKRRKILADLLQN...LE.D......RSEL...ESRQEDQDWFSGTRSRF.KTKSAYMKYNCASRIRGYLKEVDLASKSI......NKAKVREEYSRAFKLLVEMLKG-----------............................................................................................................--.-.-----------------...-------......--------------------------.--------------................................-------------------------------------......------------d...........
G3ILD5_CRIGR/1-90                    ......................................m---------....----------------...--.-......----...-----------------.-----------------------------......---------------------------------............................................................................................................--.-.-----------------...--DSCLS......KHSINPYGNRESRILFSTWNLDHIIE.KRRTVVPTLAEAI-................................---QDGREVNWEYFYSLLFTAENLKLVHIACHKKTTH......-RLQCDHSRIYR............
H3C5P7_TETNG/101-324                 ......................................v-KAAEDLLR...dERSPKSRKVLSDLLLN...LE.D......RSEL...ETRDQDADWFRGVGPWF.KTKSDYMKHSCRSRIRGYTREVKSS-KSI......KKAKVRKEFQKASESLEEMLKEAKYNGCYFDRS............................................................................................................AE.E.EERLCTPEGWFTCQGSF...DQEACSF......FHSINPYSSYESRIVFSTWNLDHRIE.KRRTVIPTLLGAV-................................-ERHGQARVDLGYFYQLLFTTRNLKLVHIVCHKKEAH......-NLACDGRKL--lr..........
E2BEW9_HARSA/1-84                    ......................................m---------....----------------...--.-......----...-----------------.-----------------------------......---------------------------------............................................................................................................--.-.-----------------...--DDCAYg....dRHKINPYRSKEEFVLFSTWNLDHKIE.RSRTLVPKLLQIS-................................-LQDIINEQDIYDCYDNLFTVKNLKLVHIVCHDKGLH......------------k...........
I3JHL3_ORENI/102-326                 ......................................i-EAAKGLLS...dEKSSKRRKILTDLLQN...LE.D......RSEL...ESREEDEGWFQGVDSRF.KTKSAYMKYNCESRIRGYLKELDDATKSI......QKAKVRAEFLKTSQSLTEMLKTAKYNGCYFDRT............................................................................................................EK.Q.PDRLCTQEGWFTCQGSF...DEKVCKS......LHSINPYGSREGRIVFSTWNLDHRIE.KKRTVIPALLEAL-................................-QNHRSTDINLNYFYQLLFTRENLKLVHIVCHKKGSH......-NLQCDTKKIY-n...........
G3RC98_GORGO/124-347                 ......................................i-QAAQQLLC...dEQAPQRQRLLADLLHN...VS.Q......NIAA...ETRAEDPPWFEGLESRF.QSKSGYLRYSCESRIRSYLREVSSYPSTV......-GAEAQEEFLRVLGSMCQKLRSMQYNGSYFDRG............................................................................................................AK.G.GSRLCTPEGWFSCQGPF...DMDSCLS......RHSINPYSNRESRILFSTWNLDHIIE.KKRTIIPTLVEAI-................................-KEQDGREVDWEYFYGLLFTSENLKLVHIVCHKKTTH......-KLNCDPSRIYK............
A7RES0_NEMVE/56-282                  ......................................v-DQIRDLMT...gDESSEMYSVMAAFLNQ...LQ.E......NIEA...ETKEDDPLWFEGVSASF.QTKEDAMKASAQSRIRNYFSTAKEYIEKE......GSKRSKPLLLAALSNFQQQLKKDHYFGSYFVRS............................................................................................................AC.E.SQRLCCSDGWFNCMGKF...DSSHCTK......LHKINPYGSKEGRVLFSTWNLDHVIE.KSREILPSMVKAAE................................-ECPKGKQLNWKYFYSLLFTCVNLKLVHITCHFKGEH......EGQVCSTKQFY-e...........
F6VS33_HORSE/63-285                  ......................................i-QAARQLLS...gELAPLRQKLLVDLLHT...VS.E......NIAA...ETRAEDPPWFEGLESRF.RSKSSYLRYSCESRIRGYLREVGAYSSLV......-GAEAQEEYVQIVEAMSRRLRAMSYNGSYFDRG............................................................................................................AK.-.ASRLCTPEGWFSCQGPF...DVDDCVS......KHSINPYSNRESRVLFSTWNLDHVIE.KKRTIVPTLAEAI-................................-KEQDGREIDWEYFYSLLFTSENLKLVHIACHKKTNH......-KLSCDPDRIYK............
I3M3Q6_SPETR/103-326                 ......................................i-EAARQLLS...gERAPLRQKLLADLLHT...VS.Q......NIEA...ETRAQDPPWFEGLESRF.RSKSGYLRYSCESRIRSYLREVSSCS-RV......LGAEAREEYLRILGAMCQRLRSSQYNGSYFDRG............................................................................................................AE.A.GSRLCTREGWFSCQGPF...DLDSCAS......KHSINPYSNRESRVLFSTWNLDHIIE.KKRTIVPTLAEAI-................................-QEQGGREVDWEYFYSLLFTSENLKLVHIACHKKTTH......-KLECDPGRIYR............
B3MV75_DROAN/151-436                 ......................................p-DKFRRMIT....EYELQKQRRVLDNTKA...H-.-......---L...SLKADHVEWFEGGEERF.HSKEEAMAMRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINSVLEQFRYLLIGCDYFSMMFNRKfeqkheflqqhqlgeeetdav..................................................................svpskrlrqvikeytkensilDE.W.SVSLCTDLGDFYCQGSYs.eNGNCCSM......QHSINPYASRENLILFQVWNLDHQIE.LCRTILPAIVASVEelitq.....................phrkcaVHNKRVVDISVLEYFLEIFSLKNLRLVHIVCHEKTPRkn.rsnGRLLCPECHEYR............
W5LKE6_ASTMX/107-333                 .....................................is--AAKRLLTddgeELPAKRRKLLGDLLNN...LT.D......SAEL...ENRTQDQDWFQGIDSRF.KTKSAYMRFNCEQRIRGYLKEVDGHAQSI......VSVREREKYKKLVVNLVERLKSDRYNGRYFDRT............................................................................................................-E.Q.QHRLCTDDGWFTCQGAF...DEQNCES......LHSINPYGNRESRILFSTWNLDHRIE.KKRAVLPALVEAL-................................-HGQKISSINLDYFYRLLFTRTNLKLVHIVCHKKGAH......-NLSCDPRQLY-n...........
F7DWB0_ORNAN/1-179                   .......................................---------....----------------...--.-......----...-----------GLESRF.KNKSGYMRYSCESRIRSYMKEVNTSASAI......-GPKAQAEYLKIIGCMGEKLKAAQYNGGYFDRR............................................................................................................-E.K.RARLCTPEGWFSCQGPF...DIDSCLS......KHSINPYSNRESRILFSTWNLDHIIE.KKRTVVPTLAEAV-................................-REQDGREVDWEYFYNLLFTSENLKLVHIACHKKTSH......-NLSCDKTRIYR............
M3Y775_MUSPF/63-286                  ......................................i-QAARQLLS...dEQAPLRQKLLADLLHT...VS.E......NIAA...ETRAEDPPWFEGLESRF.RTKSGYLRYSCESRIRSYLREVSSYASVV......-SVEAQEEYSRIVAVMGRELRAAQYHGTYFDRG............................................................................................................AK.A.GHRLCTPEGWFCCQGPF...DVDACAS......KHSINPYGNRESRVLFSTWNLDHIIE.KKRTVVPTLAEAV-................................-TARDGREVAWEYFYDLLFTSENLKLVHIACHKKTTH......-KLSCDPRRLYR............
A0A091DI54_FUKDA/69-292              ......................................l-QAARQLLE...dEQAPLRQKLLADLLQS...AS.Q......NIAA...ETRAQDPPWFDGLESRF.RNKSGYLRYSCESRIRGYLREVSSYASEV......-AVGAREEYLRVLGSMCQKLKAVQYHGSYFDRG............................................................................................................AE.A.GGRLCTLEGWFSCQGPF...DLEDCAS......KHSINPYSNRESRILFSTWNLDHIIE.KKRTVVPTLADAI-................................-QQQGGREVDWEYFYSLLFTPENLKLVHIACHKKTTH......-KLECDPRRIYR............
G7NTB1_MACFA/100-172                 ......................................v-QAAQQLLC...dEQAPQRQRLLADLLHN...VS.Q......NTAA...ETRAEDPPWFEGLESRF.QNKSGYLRYSCESRIRSYLREV-------......---------------------------------............................................................................................................--.-.-----------------...-------......--------------------------.--------------................................-------------------------------------......------------s...........
U3I6P3_ANAPL/56-279                  ......................................i-KAAQKLLS...dEQAPRRQKLLADLIHN...LQ.E......NIAA...EDRQEDSKWFEGLESRF.KNKSSYMRYSCESRIRSYMKEVKVSVVNV......-HPTARDAYKRIIDLMSDKLKSAKYNGCYFDRR............................................................................................................ED.E.AVRLCTTEGWFSCQGPF...DRDDCPC......KHSINPYSNKESRILFSTWNLDHIIE.KKRTVVPELAEAV-................................-KTRDGREVNWEYFYQLLFTIDNLKLVHIACHKKTGH......-NLSCDKTKIYR............
B4JZC1_DROGR/136-424                 ..................................ieqhp-DKFRRMIM....EYEQQKQQRALDNTKA...H-.-......---L...SLKAEHMEWFEGSEERF.QSKEEAMAMRAQTRVRGYYYKTKEELTRTpl..yrQNSKARQVINSVLEQFRYLLIGCDYFSMMFNRKcqqkheillqqigeeqpdav...................................................................svpnkrlrqvikdytvrnailDE.W.SVSLCTDLGDFYCQGAYs.dNGNFCSM......QHTINPYASRENLILFQVWNLDHQIE.LCRSILPALVDNVQelvtq.....................pqrkcaLHKKRVVDISVLEYFLEIFSLKNLKLVHIVCHEKVQRvn.rsnGRLLCADCHEYR............
U3K4V3_FICAL/17-241                  ......................................v-EAARRLLT...dERAPHRQKLLADLIHN...LS.E......NILA...EDKEDDKKWFEGLESRF.KNKSSYLRHSCESRMRGYMREVSGFISNV......-HPAARDAYRGIIDLMADKLKSVKYNGCYFDRK............................................................................................................EE.EeAARLCTAEGWFSCQGPF...DRDDCPC......KHSINPYSNRESRILFSTWNLDHIIE.KKRAVVPELAEAV-................................-KTRDGREVNWEYFYQLLFTLDNLKLVHIACHKKTNH......-NLSCDKTRIYR............
B4IEI7_DROSE/151-435                 ......................................p-EKFRRMIT....EYEQQKQRRVLDNSKA...H-.-......---L...SLKAEHVEWFTGGEERF.HSKEEAMATRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINSVLEKFRYLLIGCDFFSMMFDRNckqkheflqqhlgdeetdag...................................................................ripskrlrqvikeytkencilDE.W.STSLCSDLGDFYCQGSYs.eNGNSCSK......QHTINPYASRENLILFQVWNLDHQIE.LCRTILPALVANVEelvsh.....................pqtkcsLHKKQVVDISVLEYFLEIFSLKNLKLVHIVCHEKAQRsn.rsnGRLLCSDCHEYR............
H2PXW1_PANTR/143-296                 ..............................evssypstv---------....----------------...--.-......----...-----------------.-----------------------------......-GAEAQEEFLRVLGSMCQKLRSVQYNGSYFDRG............................................................................................................AK.G.GSRLCTPEGWFSCQGPF...DMDSCLS......RHSINPYSNRESRILFSTWNLDHIIE.KKRTIIPTLVEAI-................................-KEQDGREVDWEYFYGLLFTSENLKLVHIVCHKKTTH......-KLNCDPSRIYK............
F7F2F7_MONDO/103-326                 ......................................i-QAAQKLLT...dERAPLRQKVLADFLHN...IN.E......NIQA...ETREEDAPWFEGLESRF.RSKSSYLRYSCESRIRSYLKEVNAHATTL......-KPQPQAEYLKIIGHMYEKLKSTRYNGSYFDRR............................................................................................................DK.G.RERLCTAEGWFSCQGPF...DLDSCLS......IHSINPYSNRESRILFSTWNLDHRIE.KKRTIVPALAEAV-................................-AKQDGREVDWEYFYNLLFTSNNLKLVHIACHKKCSH......-NLSCDETRIYK............
J9KG38_ACYPI/96-331                  .....................................si--KIKSFMD....ENIKEKIRILSSVLDV...DD.E......SKKKkisSLRLRDPDWFQGLETRA.RTKEEFMFKRCQERIRSYMYKTKSDMIKSdf..yiKQTKCRKYLDEVFKQFSELLTKNKHHGYYFDRS............................................................................................................--.N.TNGLCDEIGTFKCEGAW...NQSVCSYer..gtGHKINPYQSRESRIIFSTWNLDHWVE.RSRTIIPALFEASK................................MASEVHRSINMNYFYELLFTTVNLKLVHIVCHDKGQH......ISAKCDPN----lylq........
Q9V3H0_DROME/151-435                 ......................................p-EKFRRMIT....EYEHQKQRRVLDNSKT...H-.-......---L...SLKAEHVEWFTGGEERF.HSKEEAMATRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINSVLEKFRYLLIGCDFFSMMFDRNckqkheflkqhlgdeetdag...................................................................ripskrlrqvireytkencilDE.W.STSLCSDLGDFYCQGSYs.eNGNSCSK......QHTINPYASRENLILFQVWNLDHQIE.LCRTILPALVANVEelvsh.....................pqtkcsIHKKQVVDISVLEYFLEIFSLKNLKLVHIVCHEKAQRsn.rsnGRLLCSDCHEYR............
E2R6H2_CANFA/103-326                 ......................................i-QAARQLLS...dERAPLRQKLLADLLHT...IS.E......NIAA...ETRAEDPPWFEGLESRF.QSKSGYLRYSCESRIRSYLREVNSYAPTV......-GEEAQGEYTRIVDLMCQKLRTVQYNGSYFDRG............................................................................................................AR.A.GLRLCTPEGWFCCQGPF...DVDSCAS......KHSINPYGNRESRVLFSTWNLDHIIE.KKRTVVPALAEAV-................................-TERDGREVAWEYFYSLLFTSENLKLVHIACHKKTTH......-KLSCDPHRIYK............
E0VAJ8_PEDHC/96-319                  ......................................g-TKAKELLS....DKSGEMIELLEKYEGRglvEM.D......GVEK...NTREEHPDWFKGLETNS.KTKNEYMYKKSQDRIRGYLYKFREDVRKNdr..yvTDGDFRKKIESCLNFFKCKLKTDGYYGCYFDRTfaestsdyekidspemkrkksksnr.........................................................kneiaikenmnegvnkllfnfknddeNE.L.KISYCDRFGNFQCQGHW...NENKCNFd....kGHRINPYASRETRILFSTWNFDHR--.--------------................................-------------------------------------......------------lv..........
L5MJY3_MYODS/92-163                  ......................................i-QAARQLLS...dEQAPLRQKLLADLLHT...VS.E......NIAA...ETRAEDPPWFEGLESRF.RNKCAYLRFSCASRIRTYLRE--------......---------------------------------............................................................................................................--.-.-----------------...-------......--------------------------.--------------................................-------------------------------------......------------g...........
J3KT26_HUMAN/1-63                    ......................................x---------....----------------...--.-......----...-----------------.-----------------------------......---------------------------------............................................................................................................--.-.-----------------...-------......------------------------IE.KKRTIIPTLVEAI-................................-KEQDGREVDWEYFYGLLFTSENLKLVHIVCHKKTTH......-KLNCDPSRIYK............
G3W2P1_SARHA/63-286                  ......................................i-QAAQKLLS...dERAPLRQKLLADFLHN...VN.E......NIQA...ESREEDGPWFEGLESRF.RNKSSYLRYSCESRIRSYLKEVSAYASTL......-DPKPRAEYLKIIDRMYEKLKSVHYNGSYFDRK............................................................................................................DK.G.KERLCTSEGWFSCQGPF...DLDACLS......THSINPYSNRESRILFSTWNLDHKIE.KKRTIVPTLAEAI-................................-AEQNGREVDWEYFYSLLFTSSNLKLVHIACHKKSCH......-NLSCDETRIYK............
Q17BG6_AEDAE/110-414                 .....................................gt--LVQEFVS....NNQGEIAKLLHNAQRS...QD.E......QTLK...SHRSEHAEWFEGIDEKSgQTKEEVMQRRGQDRIRGYFYKTKDELTKCai..yrQNAMAKELIDEMLDLFRQLLSGFDFFSCIFDRShsrrltegavsnlvltteehkrnqggg.....................................................devdaprimpkrmklaiekslqndgnaiEK.Y.RVALCNDRGDFSCMGLW...NETTCKY.....eAHIINPYVSRENMILFQVWNLDHQVE.IRRTVLPSIVENLKrviene....................adaickIHNRRGKKLSVITYFIELFTLGNLKLVHIVCHDKSIHdm.iskGSIICDKCAEYK............
H0YWX9_TAEGU/100-324                 ......................................v-EAARRMLT...dERAPRRQKLLADLIHN...LS.E......NILA...EDKEDDKKWFEGLESRF.KNKSSYLRHSCESRMRGYMREVSGFISNV......-HPAARDAYRGIIDLMADKLKSVKYNGCYFDRR............................................................................................................EEeE.AARLCTAEGWFSCQGPF...DRDDCPC......KHSINPYSNRESRILFSTWNLDHVIE.KKRAVVPELAEAV-................................-KTRDEREVNWEYFYQLLFTLDNLKLVHIACHKKTNH......-NLSCDKTRIYR............
H3BIK5_LATCH/105-327                 ......................................i-KAAQTLLS...dEQAPKRRKILQDLVYN...LN.E......NSSA...ETKEEDKQWFEGVESRF.KSKSDYMNYSCQSRIRSYMKEVDGYTTRV......-NPTSREEYKRIAEVMLQQLKSAKYNGCYFDRR............................................................................................................E-.K.TKRLCTREGWFSCQGAF...DTEQCST......LHSINPYGNKESRILFSTWNLDHMIE.KKRTIVPALAAAV-................................-EGQSGAEVNWEYFYRLLFTKDNLRLVHVACHKKTSH......-NLSCDKAKIYK............
A0A096MXP6_PAPAN/100-323             ......................................v-QAAQQLLC...dEQAPQRQRLLADLLHN...VS.Q......NIAA...ETRAEDPPWFEGLESRF.QNKSGYLRYSCESRIRSYLREVSSYPSLV......-GAEAQEEFLRVLGSMCQKLRSVQYNGSYFDRG............................................................................................................AK.G.GGRLCTPEGWFSCQGPF...DMDSCLS......RHSINPYSNRESRILFSTWNLDHIIE.KKRTIIPTLVEAI-................................-KEQDGREVDWEYFYGLLFTSENLKLVHIVCHKKTIH......-KLNCDPNRIYK............
A0A087X8J9_POEFO/102-326             ......................................i-EAAKGLLA...dEKSFKRRKVLTDLLQN...LE.D......RSDL...ETREEDEDWFTGVDVRF.KTKSAYMKYNCESRIRGYVKEVDNATNSI......QKAKVKEEFLKASKCLVEMLKNDKYNGKYFDRT............................................................................................................EK.E.SGRLCTKEGWFTCQGSF...EQKLCQL......LHSINPYGSRESRIVFSTWNLDHRIE.KKRTIIPALLEAL-................................-QTHKTADINLNYFYQMLFTRENLKLVHIVCHKKGAH......-DLTCDTNKMF-r...........
F7IAB5_CALJA/124-347                 ......................................i-QAAQQLLC...dERAPQRQRLLADLLHN...AT.Q......NIAA...ETRVEDPPWFEGLESRF.QSKSGYLRYSCESRIRSYLREVSSYPSMV......-GAEAQEEFLRVINSMCQKLRSVQYNGSYFDRG............................................................................................................AK.G.GHRLCTPEGWFSCQGPF...DMDSCLS......RHSINPYSNRESRILFGTWNLDHIIE.KKRAIIPTLVEAI-................................-KDQDGREVDWEYFYGLLFTSENLKLVHIVCHKKTTH......-KLSCDPNRIYK............
F1N2E0_BOVIN/103-326                 ......................................i-QAARQLLW...dERAPLRQKLLADLLGT...VS.E......NIAA...ETRAEDPPWFEGLESRF.RSKSGYLRYSCESRIRSYLREVTSGASLV......-GAEAREEYLRLVGSMQQKLQAAQYNSSYFDRG............................................................................................................AK.A.GRRLCTPEGWFSCQGPF...DVDDCTS......RHSINPYSNRESRVLFSTWNLDHVIE.KKRVVVPALAAAV-................................-HDAEGREVDWEYFYRLLFTLENLKLVHIACHKKTTH......-KLHCDPSRVY-c...........
T1GHI0_MEGSC/21-279                  edyfqtlpsqtlfiisnsnteiksetqheyeklqrrlpm---------....----------------...--.-......----...-----------------.-----------------------EELSKI.....sKTDKSMDKVDDILAKFRYLLIASNYFSMIFDRNhdkkhesvpikdetdatgsh...................................................................pppskrvreaiksycqkthllDK.W.TVSLCNDDGDFYCQGSYsegAGNFCKY......QHIINPYASRENLILFQVWNLDHQIE.LTRSVIPSLIDNIQlllnske..................gklkcpeHPKENAVDVSVVEYFLEIFSLKNLKLVHIVCHEKFQRsenrsnGRLICELCDEYK............
T1HD95_RHOPR/69-208                  .....................................gd--AILNFFD....EDIKAKVRVLSELAKE...CD.D......DLDLtlvSTKKDHPDWFIGVDSNA.ETKEEFMEKRCQDRIRNFLYKSVSDWRTSee..ykKNDVSRRSLEHIIKKLKQILSKKRFCGTYFVRG............................................................................................................--.Q.KEALCNARGDFKCSGVW...Y------......--------------------------.--------------................................-------------------------------------......------------avk.........
K7J7X5_NASVI/118-445                 ......................................g-ERAAGFLT....DKLKIKIAVLNRALNN...DD.K......KTLC...SRREDHPEWFAGLETNS.PTKEAYLHRRCQDRIRGYLYKTIEQVRSSev..ydADPQARRQLERVIVFFKLQLRKDHYFGHYFDRTrsvikskpeegvsssqsddetdsaqncpyehcpcklsissyeryilglsvdctdedddevdakkfvrsaterkaeevedelsddpkkskeplreeagekcpyelversKG.E.MTALCDETGEFRCSGVW...KNDKCLYa....dRHKINPYRSREELVLFSTWNLDHKIE.RSRTLVPQLLKVS-................................-KKGDMNEKDVLEFYNNLFTVQNLRLVHIVCHDKGAH......------------k...........
U4U402_DENPD/143-376                 ......................................g-EKVQEFFT....EKMKSKVFKLAEVLKG...LDpD......KVQM...SSRLEHPEWFEGLDTRA.KSKEEYMFRRAQDRIRTYYYKTRDDLLHT......-THLPADKLNALLSDLQTKLKLNKYHGYLFDRHat........................................................................................................agNS.N.LKPLCNSIGMFYCDGRW...DKEGCLYv....pQHSINPYTSREERIIFQTWNLDHQIE.RSRSIIPTIRRSLLqm............................ekIFDDSLPSIDVKSIYNDLFTTNNLKIVHIVCHDKGAH......VT----------kkvssyl.....
B7PNY7_IXOSC/49-277                  ..................................asrsn-----EVVA....ALEPYKSQLIEQMLGN...IE.SlevpehVLLA...DNKDQDPKWFEG-EKRA.TSKRKVMRERAKTRIKGYFYKSKEDLQKC......VSENGKQCLSQLFEEFSALLRAGDHNGHYFVRG............................................................................................................--.E.KEALCCEKGQFLCQGTF...SKPSCDS.....rVHRINPYGSREQLVCFSTWNLDHRVE.RSRSILPAIGKAI-................................-EEANGRILNARYFYKLLFTTDNLKLVHPVCHIKSEH......GGFKCERAHWY-v...........
E9ICJ0_SOLIN/1-205                   ......................................f---------....----------------...--.-......----...-----------------.-SQEAYMHRRCQDRIRTYLYKTIEQIKCSdv..fmNNNKARQQLLHTIAFFKLQLKQDHYFGYYFDRSravtdsksesdetdydrcyehcpcnlgrgindetsylhqrlpq......................ssdtpvdsdnmdetdarklresrknektesdeklescpyrvkvRE.K.QIAICDRKGEFKCEGRW...NTDGCPYg....eRHRINPYRSKEELALFSTWNLDHQ--.--------------................................-------------------------------------......------------............
D6WW09_TRICA/100-329                 ......................................g-EKVQEFFT....EKMKNKVFKLAEVLRG...ID.G......DKAK..fSLKCDHPEWFEGLDTNA.KTKEDYMFRRAQDRIRTYFYKTREELLKE......-PTLPPNRLRSLVDELQNRLKLSKFNGHFFDRS............................................................................................................--.D.NKSLCDERGEFTCQGRW...NKDMCLYs....pQHRINPYESREGRIIFQTWNLDHVIE.RSRAVIPGIVKALKda...........................ectIVNDREASVDVKAIYNDLFTLHNLKFVHIVCHDKGRH......ST----------kkagpyll....
F7I365_CALJA/100-323                 ......................................i-QAAQQLLC...dERAPQRQRLLADLLHN...AT.Q......NIAA...ETRVEDPPWFEGLESRF.QSKSGYLRYSCESRIRSYLREVSSYPSMV......-GAEAQEEFLRVINSMCQKLRSVQYNGSYFDRG............................................................................................................AK.G.GHRLCTPEGWFSCQGPF...DMDSCLS......RHSINPYSNRESRILFGTWNLDHIIE.KKRAIIPTLVEAI-................................-KDQDGREVDWEYFYGLLFTSENLKLVHIVCHKKTTH......-KLSCDPNRIYK............
DFFB_RAT/103-324                     ......................................i-QAARQLLS...dEQAPLRQKLLADLLHH...VS.Q......NITA...ETREQDPSWFEGLESRF.RNKSGYLRYSCESRIRGYLREVSAYISMV......-DAAAREEYLRVLSSMCHKLKSVQYNGSYFDRG............................................................................................................AE.A.SSRLCTPEGWFSCQGPF...DLESCLS......KHSINPYGNRESRILFSTWNLDHIIE.KKRTVVPTLAEAI-................................---QDGREVNWEYFYSLLFTAENLKLVHIACHKKTTH......-KLQCDRSRIYR............
L5MJY3_MYODS/161-293                 ......................................r---------....----------------...--.-......----...-----------------.-----------------------------......---------------------------------............................................................................................................--.-.-------------EGPF...DMADCAS......RHSINPYGSRESRVLFSTWNLDHIGHaLFRVSCPSPWCQSLwwnrpclgapagvtaxxxxxxxxxxxxxlaeaVGAQAGRQVDWEYFYSLLFTCENLKLVHIACHKKTTH......-RLSCDPRRIYR............
L5KJ86_PTEAL/103-326                 ......................................i-QAARQLLS...dERAPLRQKLLADLLHT...VS.E......NSSA...ETRAEDPPWFEGLESRF.RSKSGYLRYSCESRIRSYLREVSCHAPAV......-GAEAREEYVRVVDAMGQKLRAAQYNGGYFDRG............................................................................................................AR.A.GGRLCTPEGWFSCQGPF...DMDDCVS......KHSINPYGNRESRVLFSTWNLDHVIE.KKRTIVPTLAEAI-................................-EDRSGREIDWEYFYSLLFTSENLKLVHIACHKKTTH......-RLSCDPSRIYK............
F7EHI4_XENTR/107-330                 ......................................v-EAAHKLLA...dEDAPKRQKLLVDFISN...LN.E......NILA...ENRKDDESWFEGIESRF.KNKSSYMRYSCESRVRSYMKEVQSHTDSV......-EPVTRDEYKRIIDAMYDELRAMKYNGCYFDRT............................................................................................................EQ.K.LNRLCTSEGWFSCQGPF...DADACSS......RHSINPYSNRECRILFSTWNLDHKIE.KKRTIIPCLVKAL-................................-KERNEREVNWQYFFSLLFTKENLNLVHIACHKKTSH......-NLSLDCSQIYR............
B4MWI4_DROWI/149-435                 ......................................p-DKFRRMIT....QYELQKQRRMLDNTKA...H-.-......---L...SLREEHMEWFKGGEERF.HSKEEAMSMRAQTRVRGYYYKTKEELTRNpl..yrQNAKARQVINSVLEQFRYLLIGCDYFSMMFDRKcqqkheflshqlqqeeeetdg.................................................................aasvpkrlrqlikdytkrnnilDK.W.SVSLCSNLGDFYCQGSYs.dNGNCCSR......QHSINPYASRENLILFQVWNLDHQIE.LCRSILPSLVANVEklitq.....................pqlkctLHHKRVIDISVLEYFLEIFSLKNLKLVHITCHEKTQRtn.nsnGRLVCSECHEY-c...........
H9GDK6_ANOCA/98-319                  ......................................v-RAAQGLLS...gEEAPKRRKLLADLIHN...LS.Q......NIEA...ESREDDEKWFQGVESRF.KTKSGYMRYSCESRIRSYMKEVGAYASSL......-PPSVHAKFRQIAKAMLEKLKSERYNGFYFDRR............................................................................................................AE.K.KACLCTPEGWFSCQGPF...DTKDCPC......RHSINPYGNKESRILFSTWNLDHVIE.KKRTILPTLAEAL-................................---ADRRDVDWEYFYRLLFTVSNLKLVHIACHKKTNH......-NLSCDKRKIFR............
H0X4M1_OTOGA/103-326                 ......................................i-RAARQLLS...gEQAPLRQKLLADLLHN...VS.Q......NISA...ETRAEDPPWFEGLESRF.RSKRSYLRYSCESRIRTYLREVNSSASSV......-GAEAQEEYARILGAMCEKLKSVQYNGSYFDRG............................................................................................................AK.A.SSRLCTPEGWFSCQGPF...DMDNCLS......RHSINPYGNRESRVLFSTWNLDHIIE.KKRTIVPTLAEAI-................................-KEQNGREIDWEYFYSLLFTSENLKLVHIACHKKTTH......-KLGCDPGRIYK............
M3WFF9_FELCA/103-326                 ......................................i-QAARQLLS...gEQAPLRQKLLADLLHT...VS.E......NTEA...ETRAEDPPWFEGLESRF.KNKSGYLRYSCESRIRSYLREVSASASTV......-GAEAQEEYVRIVGLMCRKLRAEQYHSSYFDRG............................................................................................................AK.A.DSRLCTPEGWFSCQGPF...DVDSCAS......KHSINPYGNRESRILFSTWNLDHIIE.KRRTVIPTLEAAV-................................-AERAGREVSWEYFYSLLFTAHNLKLVHIACHKKTSH......-GLSCDPRRIYR............
G1SEV9_RABIT/1-180                   .......................................---------....----------------...--.-......----...-----------GLESRF.RSKSSYLRFSCESRIRSYLREVSSYVTWW......-ARRPEEEYLRVLGAMEQKLKSVRYNGSYFDRG............................................................................................................AE.A.GSRLCTPEGWFSCQGPF...DQDGCLS......RHSINPYSNRESRVLFSTWNLDHIIE.KKRTIVPTLAEAV-................................-GAQNGREVDWEYFYGLLFTTQNLKLVHVVCHKKTTH......-KLSCDPGRVYR............
F7EHJ0_XENTR/107-330                 ......................................v-EAAHKLLA...dEDAPKRQKLLVDFISN...LN.E......NILA...ENRKDDESWFEGIESRF.KNKSSYMRYSCESRVRSYMKEVQSHTDSV......-EPVTRDEYKRIIDAMYDELRAMKYNGCYFDRT............................................................................................................EQ.K.LNRLCTSEGWFSCQGPF...DADACSS......RHSINPYSNRECRILFSTWNLDHKIE.KKRTIIPCLVKAL-................................-KERNEREVNWQYFFSLLFTKENLNLVHIACHKKTSH......-NLSLDCSQIYR............
W5MFN3_LEPOC/105-329                 ......................................i-ESARGLLT...dEHAPKRRKILQELLHN...LK.E......TSDL...ESREEDEDWFEGVDSRF.KTKSAYMKYNCENRVRGYLKEVDGYTQHI......KCPRARGEYKKTVDMMTEKLKAIKYNGCYFDRK............................................................................................................EK.E.PNRLCTEEGWFSCQGAF...DQDECLS......LHSINPYGNRESRILFSTWNLDHRIE.KKRTIIPTLAEAL-................................-KKHKSSEINLDYFYRLLFTRENLKLVHIVCHKKSVH......-DLVCDKNKIYK............
F1P3V6_CHICK/74-298                  ......................................v-EAARRLLE...dERAPRRQRLLADLIHN...LS.G......DSAA...ERRDEDGKWFEGLESRF.KNKSSYMRYSCESRIRSYMKEVSNFISNV......-HPTARDAYKRILDLMSDKLKSVKYNGSYFDRT............................................................................................................EE.EaAMRLCTKEGWFSCQGPF...DRDDCPC......KHSINPYTNRESRILFSTWNLDHIIE.KKRSVVPELAEAV-................................-KTRDGREVNWEYFYQLLFTMNNLKLVHIACHKKTNH......-NLSCDKTKIYR............
B4KK42_DROMO/145-429                 ......................................p-DKFRRMIT....EYEQQKQRRALDNTKA...H-.-......---L...SLKAEHVEWFEGSEERF.QSKEEAMAVRAQTRVRGYYYKTKEELTRNpl..yrQNAKARQIINSVLEQFRYLLIGCDYFSMMFNRKcelkhemlqqhgeseepdaa...................................................................svpnkrlrqvikdytsrnailDE.W.SVSLCTDLGDFYCQGAYs.dNGNYCSL......QHTINPYASRENLILFQVWNLDHQIE.LCRTILPTLVANVQelvtq.....................pqrkcaLHNKRVVDVSVLEYFLEIFSLKNLKLVHIVCHEKVQRtn.qsnGRLLCADCHEYR............
G1MS59_MELGA/22-246                  ......................................l-EAARKLLE...dERAPRRQRLLTDLIHN...LS.G......DGAA...ERRDEDGKWFEGLESRF.KNKSSYMRYSCESRIRSYMKEFSNFISNV......-HPTARDAYKRILDLMSDKLKSVKYNGSYFDRT............................................................................................................EE.EaAMRLCTKEGWFSCQGPF...DRDDCPC......KHSINPYTNRESRILFSTWNLDHIIE.KKRSVVPELAEAV-................................-KTRDGREVNWEYFYQLLFTLNNLKLVHIACHKKTNH......-NLSCDKTKIYR............
G1Q3M5_MYOLU/1-175                   .......................................---------....----------------...--.-......----...---------------RF.RNKCAYLRFSCASRIRTYLREVSSHASVV......-GAQAREEYARAVAAMAQKLRAAQYNGSYFDRG............................................................................................................AK.G.GGRLCTPEGWFSCQGPF...DMADCAS......RHSINPYGSRESRVLFSTWNLDHIIE.KKRTVIPALAAAA-................................--GAAGRQVDWEYFYSLLFTCQNLKLVHIACHKKTTH......-GLSCDPRRIYR............
Q1L9C6_DANRE/102-326                 ......................................v-SAAQGLLS...dERSPKRRRILGDLLSN...LR.D......RSEL...ENRLQDHDWFEGIDTRF.KTKSAYMKYNCESRIRGYLKEVDGYTQTI......QNAKTKSEYKKVAEALAEKLKAARYNGTYFDRS............................................................................................................EK.D.ANRLCTEEGWFSCQGAF...DENSCNF......LHSINPYGNRESRILFSTWNLDHLIE.KKRTVIPALAKAL-................................-EANKSNDINVDYFYKLLFTRENLKLVHIVCHKKGAH......-ELSCDSRKIYK............
G3TI43_LOXAF/103-326                 ......................................i-QAARQLLS...dEQSPLRQKLLADFLHN...VS.E......NIAA...ETRAEDQQWFEGLESRF.RNKSSYLRYSCESRIRSYLREVASCASMV......-SAGAQEEYTRILGRMSQKLKSAQYHGSYFDRG............................................................................................................AR.A.DDRLCTPEGWFSCQGPF...DMDDCLS......KHSINPYSNRESRIVFSTWNLDHIIE.KKRTIVPTLAEAV-................................-KEQDGREVDWEYFYSLLFTSENLKLVHIACHKKTTH......-NLICDPSKIYR............
DFFB_MOUSE/103-324                   ......................................i-QAARQLLS...dEQAPLRQKLLADLLHH...VS.Q......NITA...ETREQDPSWFEGLESRF.RNKSGYLRYSCESRIRGYLREVSAYTSMV......-DEAAQEEYLRVLGSMCQKLKSVQYNGSYFDRG............................................................................................................AE.A.SSRLCTPEGWFSCQGPF...DLESCLS......KHSINPYGNRESRILFSTWNLDHIIE.KKRTVVPTLAEAI-................................---QDGREVNWEYFYSLLFTAENLKLVHIACHKKTTH......-KLECDRSRIYR............
#=GR DFFB_MOUSE/103-324        SS    ......................................--TTTTTS-T...BHHHHHHHHHHHHHHHH...HH.G......TTHH...HHHHHHHHHHHHGGGGG.GG-SSS-TTT-SS-TT--EE----TTSSS......--GGG-HHHHHHTTTSEEEESS-TTTTHHHHHH............................................................................................................XX.X.XXXXXXXXXXXXXXXXX...XXXXXXX......XXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXX-................................---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX......-XXXXXXXXXXX............
V4B759_LOTGI/1-79                    .......................................---------....----------------...--.-......----...-----------------.-----------------------------......-----RELLLELIEEVYNELKDNDFHGQYFDRT............................................................................................................AP.A.KKRLCDNKGWFKCQGAF...DLERCAL......LHTINPYASRGYRQLFGLWNLDHV--.--------------................................-------------------------------------......------------............
G6DK22_DANPL/100-352                 ......................................g-KAAKEFLN....VNLKEKFKVLERYISA...AN.D......SRAM..iSERTQDPDWFEGLDSSE.KTKEQSMSKRAKERMRGYYYKTKTALQSSqlyihtKNGQSKKLIDLFLLELRRRLENSKYNGDYFNRK............................................................................................................GS.E.GVRLCNENGLFECGGLW...NNKKCIYe....gEHVINPYRSREERIIFQTWNLDHKIE.LSRSIIPNIQEAIRniihan...................vkcvmcnVSSG-KGHIEIDRYYLQIFTSDNLKLVHIVCHDKGKHsa.essAYILCQKC----fgny........
L8YI78_TUPCH/695-918                 ......................................v-QAARQLMC...dEQAPLRQKLLADLLHN...LS.Q......NIEA...ETRAEDPPWFEGLESRF.RSKSSYLRYSCESRIRSYLREVSSYTSMV......-DAEAQEEYMRILDSMGQKLKSAQYNGSYFDRG............................................................................................................AK.A.SGRLCTPEGWFSCQGPF...DMDDCLS......KHSINPYGNRESRVLFSTWNLDHIIE.KKRTIVPTLAEAV-................................-KEQDGREVDWEYFYGLLFTLENLKLVHIACHKKTTH......-KLSCDPRRIYK............
H2N9C7_PONAB/100-171                 ......................................i-QAAQQLLC...dEQAPQRQRLLADLLHN...VS.Q......NIAA...ETRAEDPPWFEGLESRF.QSKSGYLRYSCESRIRSYLRE--------......---------------------------------............................................................................................................--.-.-----------------...-------......--------------------------.--------------................................-------------------------------------......------------g...........
G3NPN2_GASAC/103-327                 ......................................v-EAAKGLLS...dEPSPKRRKILTDLLHN...LQ.D......TSEV...EKREDDEDWFTGVDTRF.KTKSAYMKFNCGSRIRSYMKELDAATKTI......QRAAVRAEFLKTTKCLAEMLRSAKHNGSYFDRT............................................................................................................EK.E.AHRLCTAAGWFTCQGSF...DQEVCRS......FHSINPYGSRESRILFSTWNLDHRIE.KKRTIIPALLEAL-................................-QSHKSAEVNLHYFYRLLFTRDNLKLVHIVCHKKEAH......-HLQCDANEIF-n...........
W5JGP2_ANODA/113-410                 ......................................g-ELAKQFVS....NNQPEISKILIDAQRG...RD.D......LIRR...SSRNEHEQWFEGIDDRAvKTKEEVMKRRGQDRVRGYFYKAKDELTKCam..yrANPVARELIDEMIELFRQLLAGFDYFSCMFDRTcqrrmtvpeetigdakddvadet.............................................................dakrippkrlkllvqrslgsscriDQ.Y.NAALCSVRGDFRCMGLW...DDVRCRY.....dSHRINPYANREALILFQVWNLDHQIE.ISRTVLPSILTNIGrmvsae...................gevaickRHKRKGKQLSVITYFLELFTLHNLKLVHIVCHDKGAHdl.vsrGTIICDRCEEYQ............
E2AMM4_CAMFO/32-338                  ......................................g-DKVTQFLT....ENLKAKVALLNKVLNK...DD.S......KTAL...STRDEHPEWFKDLETNC.ITKEAYMHRRCQDRIRTYLYKTIEQIRCSdv..ymNDRKARQQLLRAIAFFKIQLKEDHYFGYYFDRSraetgnfkddsdetdskqcyehcpcnfghindetylyqpylrlp....................qssdtsttivdstktdetdarrlvkseknandeilescpygvkpQG.K.QIAICDRKGEFKCEGRW...NANGCAYs....dRHRINPYRSKEELALFSTWNLDHKIE.RSRTLIPKLLQLS-................................--QQDINEQDIYDCYDNLFTVKNLRLVHIVCHDKGSH......------------k...........
H0UTL9_CAVPO/103-326                 ......................................i-QAARQLLA...dEQAPLRQKLLVDLLQS...AS.Q......NIEA...EMRAQDPAWFEGLESRF.RNKSGYLRYSCESRIRGYLREVNAYTSEV......-ASEAREEYLRVLGAMCRKLKAAQYHGSYFDRG............................................................................................................AE.A.GSRLCTPEGWFSCQGAF...DLEDCAS......KHSINPYSNRESRILFSTWNLDHIIE.KKRTIVPTLADAI-................................-QQQDGREVDWEYFYSLLFTPANLKLVHIACHKKTTH......-KLECNPHRIYR............
G1LRH4_AILME/103-326                 ......................................i-QAARQLLS...dEQAPLRQKLLADLLHT...VS.E......NIAA...ETRDEDPPWFEGLESRF.QSKSGYLRYSCESRIRSYLREVHSYASLV......-SMEARDEYSRVADLMCRKLRASRYNGSYFDRG............................................................................................................AK.A.GGRLCTPEGWFCCQGPF...DVDTCAS......KHSINPYGNRESRVLFSTWNLDHIIE.KKRTVVPALAEAI-................................-TERDGREVAWEYFYGLLFTLENLKLVHIACHKKTTH......-KLGCDPRRIYQ............
F6WIJ2_MACMU/100-172                 ......................................v-QAAQQLLC...dEQAPQRQRLLADLLHN...VS.Q......NIAA...ETRAEDPPWFEGLESRF.QNKSGYLRYSCESRIRSYLREV-------......---------------------------------............................................................................................................--.-.-----------------...-------......--------------------------.--------------................................-------------------------------------......------------s...........
W5PYX3_SHEEP/103-326                 ......................................i-QAARQLLS...dERSPLRQKLLADLLGT...VS.E......NTAA...ETGAEAPPWFEGLESRF.RSKSGYLRYSCESRIRSYLREVTSGASLV......-GAEAREEYLRLVGSMQQKLQAAQYNSSYFDRG............................................................................................................AK.A.GRRLCTPEGWFSCQGPF...DVDDCTS......RHSINPYSNRESRVLFSTWNLDHVIE.KKRAVVPTLAAAV-................................-HDAEGRKVDWEYFYRLLFTLENLKLVHIACHKKTTH......-KLHCDPSRVY-c...........
A0A088ARL5_APIME/135-431             .................................xxxxxx---------....---KAKVAVLNNALNK...DD.S......KTAY...SSREEHPDWFQGLETNC.ATKEAYLHRRCQDRIRGYLYKTIDQIKSSdv..fsKDPRARKQLLYAIAFFKMQLKEDHYFGYYFDRSrakigslegrderdssascydhcpcrlkwldestyfrlfgt.........................igqhcddvdavkrrnernsggkgeeeekeaeetcpykirrtgED.T.CVALCDQTGEFKCYGVW...NEEKCLYg....dRHKINPYRSREELILFSTWNFDHKIE.RSRTLIPLLLKLA-................................-TQGTANEMDLFEIYDNLFTMKNLRLVHIVCHDKGSH......------------k...........
W4WPJ7_ATTCE/148-455                 ......................................g-DRVTQFLT....ENLKGKVALLNKVLNK...DD.S......KTAL...STREEHPEWFENLETNC.ITKEAYMHRRCQDRIRTYLYKTIEQIKCSdv..fmNDYKARQQLLHTIAFFKLQLKQDHYFGYYFDRSraesdtksdndetdydrcyehcpcnfgriddetylhqrylrlpq....................ssdtnsiansdkidetdarkclaseknaktanddsesyfyrvklRE.K.QIAICNKKGEFKCEGRW...NTDGCPYg....dRHKINPYKSKEDLVLFSTWNLDHKIE.RSRTLIPKLLQIS-................................-RQDTINEEDIYDCYDNLFTVKNLRLVHIVCHDKGSH......------------k...........
G5CBI1_HETGA/299-368                 .................................rvlsll---------....----------------...--.-......----...-----------------.-----------------------------......---------------------------------............................................................................................................--.-.-----------------...-------......----------------------TAIE.KKRAIVPTLVDAI-................................-QQRDGREVAWEYFYSLLFTPENLKLVHIACHKKTTH......-KLECDPRRIYR............
#=GC SS_cons                         ......................................--TTTTTS-T...BHHHHHHHHHHHHHHHH...HH.G......TTHH...HHHHHHHHHHHHGGGGG.GG-SSS-TTT-SS-TT--EE----TTSSS......--GGG-HHHHHHTTTSEEEESS-TTTTHHHHHH............................................................................................................XX.X.XXXXXXXXXXXXXXXXX...XXXXXXX......XXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXX-................................---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX......-XXXXXXXXXXX............
#=GC seq_cons                        ......................................h.ptApphLs....Eptst+p+lLsDhlps...hs.p......phth...psRt-cs.WFEGlEoRF.coKpuYh+hsCpoRIRuYhhcsps.hpps.......sspu+pph.clltthpppL+uspYpGsYFDRs............................................................................................................tc.t.stpLCoscGhFpCQGsa...chcsC........pHoINPYusREsRILFSTWNLDHhIE.+pRollPsLspAl..................................ppppsp-lshphFYthLFThcNLKLVHIsCHcKssH.......pL.C-.p+.Y.............
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