GenomeNet

Database: Pfam
Entry: DFF40
LinkDB: DFF40
Original site: DFF40 
#=GF ID   DFF40
#=GF AC   PF09230.5
#=GF DE   DNA fragmentation factor 40 kDa
#=GF AU   Sammut SJ
#=GF SE   pdb_1v0d
#=GF GA   25.00 25.00;
#=GF TC   52.10 36.10;
#=GF NC   23.10 23.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   DFFB
#=GF RN   [1]
#=GF RM   15149602
#=GF RT   Structural mechanism for inactivation and activation of
#=GF RT   CAD/DFF40 in the apoptotic pathway. 
#=GF RA   Woo EJ, Kim YG, Kim MS, Han WD, Shin S, Robinson H, Park SY, Oh
#=GF RA   BH; 
#=GF RL   Mol Cell. 2004;14:531-539.
#=GF DR   INTERPRO; IPR015311;
#=GF DR   SCOP; 1v0d; fa;
#=GF CC   Members of this family of eukaryotic apoptotic proteins induce
#=GF CC   DNA fragmentation and chromatin condensation during apoptosis
#=GF CC   [1].
#=GF SQ   108
#=GS B3NAZ4_DROER/149-435  AC B3NAZ4.1
#=GS Q8BP66_MOUSE/101-324  AC Q8BP66.1
#=GS G1R9M7_NOMLE/1-155    AC G1R9M7.1
#=GS H9IA19_ATTCE/146-455  AC H9IA19.1
#=GS G3RC98_GORGO/122-347  AC G3RC98.1
#=GS C1BL68_OSMMO/101-325  AC C1BL68.1
#=GS Q6NWG2_DANRE/112-338  AC Q6NWG2.1
#=GS B4JZC1_DROGR/138-424  AC B4JZC1.1
#=GS D2HC05_AILME/98-323   AC D2HC05.1
#=GS H2N9C7_PONAB/169-266  AC H2N9C7.1
#=GS H2PXW1_PANTR/98-150   AC H2PXW1.1
#=GS Q3KZL5_DROSN/1-269    AC Q3KZL5.1
#=GS H0UTL9_CAVPO/101-326  AC H0UTL9.1
#=GS E3WNP9_ANODA/111-410  AC E3WNP9.1
#=GS G3ILD6_CRIGR/101-237  AC G3ILD6.1
#=GS G3TI43_LOXAF/101-326  AC G3TI43.1
#=GS Q4SC73_TETNG/98-306   AC Q4SC73.1
#=GS G1LRH4_AILME/101-326  AC G1LRH4.1
#=GS F7I365_CALJA/98-323   AC F7I365.1
#=GS G5CBI1_HETGA/67-239   AC G5CBI1.1
#=GS B4P340_DROYA/149-435  AC B4P340.1
#=GS B4MWI4_DROWI/147-435  AC B4MWI4.1
#=GS G3ILD5_CRIGR/1-90     AC G3ILD5.1
#=GS E2BEW9_HARSA/1-84     AC E2BEW9.1
#=GS H3BIK5_LATCH/103-327  AC H3BIK5.1
#=GS F7EHJ0_XENTR/105-330  AC F7EHJ0.1
#=GS E2AMM4_CAMFO/30-338   AC E2AMM4.1
#=GS E0VAJ8_PEDHC/94-319   AC E0VAJ8.1
#=GS F7F2F7_MONDO/101-328  AC F7F2F7.1
#=GS G3NPN2_GASAC/101-327  AC G3NPN2.1
#=GS F7DWB0_ORNAN/1-179    AC F7DWB0.1
#=GS F1P3V6_CHICK/17-243   AC F1P3V6.1
#=GS D0AB91_9NEOP/98-350   AC D0AB91.1
#=GS B4KK42_DROMO/143-429  AC B4KK42.1
#=GS Q9NDR2_DROME/149-435  AC Q9NDR2.1
#=GS Q7Q1Q3_ANOGA/111-405  AC Q7Q1Q3.4
#=GS F1RJA2_PIG/1-62       AC F1RJA2.1
#=GS G7NTB1_MACFA/98-172   AC G7NTB1.1
#=GS H2V7W9_TAKRU/101-327  AC H2V7W9.1
#=GS E2R6H2_CANFA/101-326  AC E2R6H2.1
#=GS C1BZL4_ESOLU/100-326  AC C1BZL4.1
#=GS G6DK22_DANPL/98-353   AC G6DK22.1
#=GS F1NYL3_CHICK/15-242   AC F1NYL3.1
#=GS H2PXW1_PANTR/143-296  AC H2PXW1.1
#=GS Q1L9C6_DANRE/100-326  AC Q1L9C6.1
#=GS H0X4M1_OTOGA/101-326  AC H0X4M1.1
#=GS B1WBL0_XENTR/105-330  AC B1WBL0.1
#=GS Q3KZL8_DROSN/1-269    AC Q3KZL8.1
#=GS Q3KZM4_DROSN/1-269    AC Q3KZM4.1
#=GS DFFB_BOVIN/101-326    AC Q58CZ0.1
#=GS Q3KZM0_DROYA/1-269    AC Q3KZM0.1
#=GS Q17BG6_AEDAE/108-414  AC Q17BG6.1
#=GS Q3KZM7_DROYA/1-269    AC Q3KZM7.1
#=GS H2MYH3_ORYLA/96-199   AC H2MYH3.1
#=GS G7MGI5_MACMU/286-362  AC G7MGI5.1
#=GS DFFB_HUMAN/98-323     AC O76075.1
#=GS H2N9C7_PONAB/98-171   AC H2N9C7.1
#=GS H9KHC3_APIME/104-324  AC H9KHC3.1
#=GS DFFB_MOUSE/101-324    AC O54788.1
#=GS DFFB_MOUSE/101-324    DR PDB; 1V0D A; 101-324;
#=GS G1MS59_MELGA/20-246   AC G1MS59.2
#=GS Q8UVS5_CHICK/98-324   AC Q8UVS5.1
#=GS Q3L0E4_DROYA/9-282    AC Q3L0E4.1
#=GS H3D014_TETNG/98-323   AC H3D014.1
#=GS G1R9M5_NOMLE/98-227   AC G1R9M5.1
#=GS A9XB03_DROTE/34-308   AC A9XB03.1
#=GS Q3KZN0_DROYA/1-269    AC Q3KZN0.1
#=GS Q3KZM9_DROYA/1-269    AC Q3KZM9.1
#=GS E9ICJ0_SOLIN/1-205    AC E9ICJ0.1
#=GS Q9V3H0_DROME/149-435  AC Q9V3H0.1
#=GS Q3KZM3_DROSN/1-269    AC Q3KZM3.1
#=GS F7EHI4_XENTR/105-330  AC F7EHI4.1
#=GS H0YWX9_TAEGU/98-324   AC H0YWX9.1
#=GS Q9DGL7_DANRE/100-326  AC Q9DGL7.1
#=GS B4Q4R0_DROSI/149-435  AC B4Q4R0.1
#=GS F6WIJ2_MACMU/98-172   AC F6WIJ2.1
#=GS DFFB_RAT/101-324      AC Q99N34.1
#=GS Q7TS81_MOUSE/101-323  AC Q7TS81.1
#=GS Q3KZL9_DROYA/1-269    AC Q3KZL9.1
#=GS G1SEV9_RABIT/1-180    AC G1SEV9.1
#=GS F6VS33_HORSE/61-285   AC F6VS33.1
#=GS B4IEI7_DROSE/149-435  AC B4IEI7.1
#=GS F4WNU5_ACREC/101-410  AC F4WNU5.1
#=GS B7PNY7_IXOSC/51-277   AC B7PNY7.1
#=GS G1Q3M5_MYOLU/1-175    AC G1Q3M5.1
#=GS E9GG77_DAPPU/120-330  AC E9GG77.1
#=GS B3MV75_DROAN/149-436  AC B3MV75.1
#=GS C3YR00_BRAFL/97-325   AC C3YR00.1
#=GS F1N2E0_BOVIN/101-326  AC F1N2E0.1
#=GS H9GDK6_ANOCA/101-324  AC H9GDK6.1
#=GS Q3KZM2_DROYA/1-269    AC Q3KZM2.1
#=GS B1AX96_MOUSE/101-324  AC B1AX96.1
#=GS B4M987_DROVI/146-432  AC B4M987.1
#=GS Q3L0E5_DROSN/9-282    AC Q3L0E5.1
#=GS Q3KZM8_DROYA/1-269    AC Q3KZM8.1
#=GS F7IAB5_CALJA/122-347  AC F7IAB5.1
#=GS G3W2P1_SARHA/61-286   AC G3W2P1.1
#=GS Q29KJ1_DROPS/151-440  AC Q29KJ1.2
#=GS A9XB02_DROOR/36-312   AC A9XB02.1
#=GS G7MGI5_MACMU/98-277   AC G7MGI5.1
#=GS D6WW09_TRICA/98-327   AC D6WW09.1
#=GS H3C5P7_TETNG/99-324   AC H3C5P7.1
#=GS Q5SR21_HUMAN/34-259   AC Q5SR21.1
#=GS H9KHC2_APIME/116-336  AC H9KHC2.1
#=GS G3MSS0_9ACAR/1-194    AC G3MSS0.1
#=GS B0WHX2_CULQU/109-423  AC B0WHX2.1
#=GS B4DZS0_HUMAN/122-347  AC B4DZS0.1
#=GS G5CBI1_HETGA/299-368  AC G5CBI1.1
#=GS A7RES0_NEMVE/54-282   AC A7RES0.1
B3NAZ4_DROER/149-435             ...........QHPEKFRRMITEYEDQKQRCVLDN---..-...--SKAHLSLKDEHVEWFAGG..EER.FHSKEEAMAMRAQTRVRGYYYKAKEQLTRNpl..yrQNVKARQVINAVLEKFRYLLIGCDFFSMIFDRSCKQKHeflqqhlgeeetdagripsk...............................................rlrqvikeytkencildewsTSLCSDLGDFYCQGSYSENgnSC..S..K..Q..HTINPYASRENLILFQVWNL.DHQIELCRTILPALVA.NVEELVshpqik...cslhnkQVVDISVLEYFLEIFSLKNLKLVHIVCHERVQRSNRsngrlLCPDCHEYR.........
Q8BP66_MOUSE/101-324             ..........g-VIQAARQLLSDEQAPLRQKLLADLLH..H...VSQNITAETREQDPSWFEGL..ESR.FRNKSGYLRYSCESRIRGYLREVSAYTSMV......-DEAAQEEYLRVLGSMCQKLKSVQYNGSYFDRG-AEAS.......................................................................................SRLCTPEGWFSCQGPFDLE..SC..L..S..K..HSINPYGNRESRILFSTWNL.DHIIEKKRTVVPTLAE.AIQD--...............-GREVNWEYFYSLLFTAENLKLVHIACHKKTTHKLE.....-CDRSRIYR.........
G1R9M7_NOMLE/1-155               ..qvssypstv---------------------------..-...--------------------..---.------------------------------......-GAEAQEEFLRVLGSMCQKLRSVQYNGSYFDRG-AKGG.......................................................................................GRLCTPEGWFSCEVSYAAL..EC..P..S..L..HAHHPCEFTLSRVLADTWCSaQQTIEKKRTIIPTLVE.AIKE-Q...............DGREVDWEYFYGLLFTSENLKLVHIVCHKKTTHKLN.....-CDPSRIYK.........
H9IA19_ATTCE/146-455             .........ta--GDRVTQFLTENLK-GKVALLNKVLN..K...DDSKTALSTREEHPEWFENL..ETN.CITKEAYMHRRCQDRIRTYLYKTIEQIKCSdv..fmNDYKARQQLLHTIAFFKLQLKQDHYFGYYFDRSRAESDtksdndetdydrcyehcpcnfgriddetylhqrylrlpqssdtnsiansdkidetdarkclaseknaktanddsesyfyrvklrekqIAICNKKGEFKCEGRWNTD..GC..PygD..R..HKINPYKSKEDLVLFSTWNL.DHKIERSRTLIPKLLQ.ISRQ-D...............TINEEDIYDCYDNLFTVKNLRLVHIVCHDKGSHK--.....---------.........
G3RC98_GORGO/122-347             .........gl--IQAAQQLLCDEQAPQRQRLLADLLH..N...VSQNIAAETRAEDPPWFEGL..ESR.FQSKSGYLRYSCESRIRSYLREVSSYPSTV......-GAEAQEEFLRVLGSMCQKLRSMQYNGSYFDRG-AKGG.......................................................................................SRLCTPEGWFSCQGPFDMD..SC..L..S..R..HSINPYSNRESRILFSTWNL.DHIIEKKRTIIPTLVE.AIKE-Q...............DGREVDWEYFYGLLFTSENLKLVHIVCHKKTTHKLN.....-CDPSRIYK.........
C1BL68_OSMMO/101-325             ..........h-VIEEARKLPSDEQSPKKRKLLGDLLL..H...LKDCSEAESRKEDGEWFHGI..DVR.FKTKSSYMKYNCESRIRGYMKEVNGYAKNI......EKPKVRAEYIKTAACLVSKLKSDKYHGWYFDRT---EN.......................................................................................DCLCTAEGWFTCQGAFDKE..EC..K..S..L..HSINPYGNRESRIMFSTWNL.DHRIEKKRTVIPALVE.ALQN-H...............KSSDINLDYFYKLLFTTDNLKLVHIVCHKKGTHDLV.....-CDKRKMYQ.........
Q6NWG2_DANRE/112-338             .........ll--VSAAQGLLSDERSPKRRRILGDLLS..N...LRDRSELENRLQDHDWFEGI..DTR.FKTKSAYMKYNCESRIRGYLKEVDGYTQTI......KNAKTKSEYKKVAEALAEKLKAARYNGTYFDRS-EKDA.......................................................................................NRLCTEEGWFSCQGAFDEN..SC..N..F..L..HSINPYGNRESRILFSTWNL.DHLIEKKRTVIPALAK.ALEA-N...............KSNDINVDYFYKLLFTRENLKLVHIVCHKKGAHELS.....-CDSRKIYK.........
B4JZC1_DROGR/138-424             ...........QHPDKFRRMIMEYEQQKQQRALDN---..-...--TKAHLSLKAEHMEWFEGS..EER.FQSKEEAMAMRAQTRVRGYYYKTKEELTRTpl..yrQNSKARQVINSVLEQFRYLLIGCDYFSMMFNRKCQQKHeillqqigeeqpdavsvpnk...............................................rlrqvikdytvrnaildewsVSLCTDLGDFYCQGAYSDNgnFC..S..M..Q..HTINPYASRENLILFQVWNL.DHQIELCRSILPALVD.NVQELVtqpqrk...calhkkRVVDISVLEYFLEIFSLKNLKLVHIVCHEKVQRVNRsngrlLCADCHEYR.........
D2HC05_AILME/98-323              .........gl--IQAARQLLSDEQAPLRQKLLADLLH..T...VSENIAAETRDEDPPWFEGL..ESR.FQSKSGYLRYSCESRIRSYLREVHSYASLV......-SMEARDEYSRVADLMCRKLRASRYNGSYFDRG-AKAG.......................................................................................GRLCTPEGWFCCQGPFDVD..TC..A..S..K..HSINPYGNRESRVLFSTWNL.DHIIEKKRTVVPALAE.AITE-R...............DGREVAWEYFYGLLFTLENLKLVHIACHKKTTHKLG.....-CDPRRIYQ.........
H2N9C7_PONAB/169-266             .........re---------------------------..-...--------------------..---.------------------------------......--------------------------------------.......................................................................................-------------GPFDMD..SC..L..S..R..HSINPYSNRESRILFSTWNL.DHIIEKKRTIIPTLVE.AIKE-Q...............DGREVDWEYFYGLLFTSENLKLVHIVCHKKTTHKLN.....-CDPSRIYK.........
H2PXW1_PANTR/98-150              .........gl--IQAAQQLLCDEQAPQRQRLLADLLH..N...VSQNIAAETRAEDPPWFEV-..---.------------------------------......--------------------------------------.......................................................................................-------------------..--..-..-..-..--------------------.----------------.------...............------------------------------------.....---------ssypst...
Q3KZL5_DROSN/1-269               ...........QHPEKFRRMITEYEHQKQRRVLDN---..-...--SKAHLSLKAEHMEWFAGG..EER.FHSKEEAMAMRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINAVLEKFRYLLIGCDFFSMMFDRNCKQKHeflqqhlgeeetdagripsk...............................................rlrqvikeytkencildewsTSLCSDLGDFYCQGSYSENgnSC..S..K..Q..HXINPYASRENLILFQVWNL.DHQIELCRTILPALVA.NVEELVshpqik...cslhkkXVVDISVLEYFLEIFSLKNLKLVHIVCHEKV-----.....---------q........
H0UTL9_CAVPO/101-326             ..........g-VIQAARQLLADEQAPLRQKLLVDLLQ..S...ASQNIEAEMRAQDPAWFEGL..ESR.FRNKSGYLRYSCESRIRGYLREVNAYTSEV......-ASEAREEYLRVLGAMCRKLKAAQYHGSYFDRG-AEAG.......................................................................................SRLCTPEGWFSCQGAFDLE..DC..A..S..K..HSINPYSNRESRILFSTWNL.DHIIEKKRTIVPTLAD.AIQQ-Q...............DGREVDWEYFYSLLFTPANLKLVHIACHKKTTHKLE.....-CNPHRIYR.........
E3WNP9_ANODA/111-410             ..........n-AGELAKQFVSNNQ-PEISKILIDAQR..G...RDDLIRRSSRNEHEQWFEGI.dDRA.VKTKEEVMKRRGQDRVRGYFYKAKDELTKCam..yrANPVARELIDEMIELFRQLLAGFDYFSCMFDRTCQRRMtvpeetigdakddvadetdakri.........................................ppkrlkllvqrslgsscridqynAALCSVRGDFRCMGLWDDV.rCR..Y..D..S..HRINPYANREALILFQVWNL.DHQIEISRTVLPSILT.NIGRMVsaegeva.ickrhkrKGKQLSVITYFLELFTLHNLKLVHIVCHDKGAHDLVsrgtiICDRCEEYQ.........
G3ILD6_CRIGR/101-237             ..........g-VIRAARQLLSDEQAPRRQKLLADLLH..H...VSQNITAETREQDPSWFEGL..ESR.FRNKSGYLRYNCESRIRGYLREVSAYTSVV......-DAAARGEFERVLSSMSQKLKSVKYNGSYFDRG-AEAS.......................................................................................SRLCTPEGWFSCQVRF---..--..-..-..-..--------------------.----------------.------...............------------------------------------.....---------vdrg.....
G3TI43_LOXAF/101-326             ..........g-VIQAARQLLSDEQSPLRQKLLADFLH..N...VSENIAAETRAEDQQWFEGL..ESR.FRNKSSYLRYSCESRIRSYLREVASCASMV......-SAGAQEEYTRILGRMSQKLKSAQYHGSYFDRG-ARAD.......................................................................................DRLCTPEGWFSCQGPFDMD..DC..L..S..K..HSINPYSNRESRIVFSTWNL.DHIIEKKRTIVPTLAE.AVKE-Q...............DGREVDWEYFYSLLFTSENLKLVHIACHKKTTHNLI.....-CDPSKIYR.........
Q4SC73_TETNG/98-306              ..........a-VVKAAEDLLRDERSPKSRKVLSDLLL..N...LEDRSELETRDQDADWFRGV..GPW.FKTKSDYMKHSCRSRIRGYTRELREASKSI......KKAKVRKEFQKASESLEEE-------------------.......................................................................................ERLCTPEGWFTCQGSFDQE..AC..S..F..F..HSINPYSSYESRIVFSTWNL.DHRIEKRRTVIPTLLG.AVER-H...............GQARVDLGYFYQLLFTTRNLKLVHIVCHKKEAHNLA.....-CDGRKLL-r........
G1LRH4_AILME/101-326             .........gl--IQAARQLLSDEQAPLRQKLLADLLH..T...VSENIAAETRDEDPPWFEGL..ESR.FQSKSGYLRYSCESRIRSYLREVHSYASLV......-SMEARDEYSRVADLMCRKLRASRYNGSYFDRG-AKAG.......................................................................................GRLCTPEGWFCCQGPFDVD..TC..A..S..K..HSINPYGNRESRVLFSTWNL.DHIIEKKRTVVPALAE.AITE-R...............DGREVAWEYFYGLLFTLENLKLVHIACHKKTTHKLG.....-CDPRRIYQ.........
F7I365_CALJA/98-323              .........gl--IQAAQQLLCDERAPQRQRLLADLLH..N...ATQNIAAETRVEDPPWFEGL..ESR.FQSKSGYLRYSCESRIRSYLREVSSYPSMV......-GAEAQEEFLRVINSMCQKLRSVQYNGSYFDRG-AKGG.......................................................................................HRLCTPEGWFSCQGPFDMD..SC..L..S..R..HSINPYSNRESRILFGTWNL.DHIIEKKRAIIPTLVE.AIKD-Q...............DGREVDWEYFYGLLFTSENLKLVHIVCHKKTTHKLS.....-CDPNRIYK.........
G5CBI1_HETGA/67-239              .........gv--LQVARQLLEDEQAPLRQKLLADLLQ..S...ASQNIAAETRAQDPPWFEGV..ESR.FRNKSGYLRYSCESRIRGYLREVSTYASGV......-AVGAREEYLRVLDSMCQKLKAAQYHGSYFDRE-AEAG.......................................................................................GRLCTPEGWFSCQGPFDLE..NC..A..S..K..HSINPYSNRESRILFSTWNL.DHM-------------.------...............------------------------------------.....---------pgvkvqrea
B4P340_DROYA/149-435             ...........QHPEKFRRMITEYEHQKQRRVLDN---..-...--SKAHLSLKAEHMEWFTGG..EER.FHSKEEAMAMRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINAVLEKFRYLLIGCDFFSMMFDRNCKQKHeflqqhlgeeetdagripsk...............................................rlrqvikeytkencildewsTSLCSDLGDFYCQGSYSENgnSC..S..K..Q..HTINPYASRENLILFQVWNL.DHQIELCRTILPALVA.NVEELVshpqik...cslhkkQVVDISVLEYFLEIFSLKNLKLVHIVCHEKAQRSNRsngrlLCSDCHEYR.........
B4MWI4_DROWI/147-435             ..........k-HPDKFRRMITQYELQKQRRMLDN---..-...--TKAHLSLREEHMEWFKGG..EER.FHSKEEAMSMRAQTRVRGYYYKTKEELTRNpl..yrQNAKARQVINSVLEQFRYLLIGCDYFSMMFDRKCQQKHeflshqlqqeeeetdgaasvp.............................................krlrqlikdytkrnnildkwsVSLCSNLGDFYCQGSYSDNgnCC..S..R..Q..HSINPYASRENLILFQVWNL.DHQIELCRSILPSLVA.NVEKLItqpqlk...ctlhhkRVIDISVLEYFLEIFSLKNLKLVHITCHEKTQRTNNsngrlVCSECHEYC.........
G3ILD5_CRIGR/1-90                ..........m---------------------------..-...--------------------..---.------------------------------......--------------------------------------.......................................................................................------------------D..SC..L..S..K..HSINPYGNRESRILFSTWNL.DHIIEKRRTVVPTLAE.AIQD--...............-GREVNWEYFYSLLFTAENLKLVHIACHKKTTHRLQ.....-CDHSRIYR.........
E2BEW9_HARSA/1-84                ....mddcayg---------------------------..-...--------------------..---.------------------------------......--------------------------------------.......................................................................................-------------------..--..-..D..R..HKINPYRSKEEFVLFSTWNL.DHKIERSRTLVPKLLQiSLQDII...............NEQ--DIYDCYDNLFTVKNLKLVHIVCHDKGLHK--.....---------.........
H3BIK5_LATCH/103-327             ..........e-IIKAAQTLLSDEQAPKRRKILQDLVY..N...LNENSSAETKEEDKQWFEGV..ESR.FKSKSDYMNYSCQSRIRSYMKEVDGYTTRV......-NPTSREEYKRIAEVMLQQLKSAKYNGCYFDRR--EKT.......................................................................................KRLCTREGWFSCQGAFDTE..QC..S..T..L..HSINPYGNKESRILFSTWNL.DHMIEKKRTIVPALAA.AVEG-Q...............SGAEVNWEYFYRLLFTKDNLRLVHVACHKKTSHNLS.....-CDKAKIYK.........
F7EHJ0_XENTR/105-330             ..........c-IVEAAHKLLADEDAPKRQKLLVDFIS..N...LNENILAENRKDDESWFEGI..ESR.FKNKSSYMRYSCESRVRSYMKEVQSHTDSV......-EPVTRDEYKRIIDAMYDELRAMKYNGCYFDRT-EQKL.......................................................................................NRLCTSEGWFSCQGPFDAD..AC..S..S..R..HSINPYSNRECRILFSTWNL.DHKIEKKRTIIPCLVK.ALKE-R...............NEREVNWQYFFSLLFTKENLNLVHIACHKKTSHNLS.....-LDCSQIYR.........
E2AMM4_CAMFO/30-338              .........ta--GDKVTQFLTENL-KAKVALLNKVLN..K...DDSKTALSTRDEHPEWFKDL..ETN.CITKEAYMHRRCQDRIRTYLYKTIEQIRCSdv..ymNDRKARQQLLRAIAFFKIQLKEDHYFGYYFDRSRAETGnfkddsdetdskqcyehcpcnfghindetylyqpylrlpqssdtsttivdstktdetdarrlvkseknandeilescpygvkpqgkqIAICDRKGEFKCEGRWNANgcAY..S..D..R..HRINPYRSKEELALFSTWNL.DHKIERSRTLIPKLLQ.LSQQ--...............DINEQDIYDCYDNLFTVKNLRLVHIVCHDKGSHK--.....---------.........
E0VAJ8_PEDHC/94-319              .........da--GTKAKELLSDKS-GEMIELLEKYEG..RglvEMDGVEKNTREEHPDWFKGL..ETN.SKTKNEYMYKKSQDRIRGYLYKFREDVRKNdr..yvTDGDFRKKIESCLNFFKCKLKTDGYYGCYFDRTFAESTsdyekidspemkrkksksnrkneia.....................................ikenmnegvnkllfnfknddenelkISYCDRFGNFQCQGHWNEN..KC..N..F..DkgHRINPYASRETRILFSTWNF.DHR-------------.------...............------------------------------------.....---------lv.......
F7F2F7_MONDO/101-328             ..........d-VIQAAQKLLTDERAPLRQKVLADFLH..N...INENIQAETREEDAPWFEGIslESR.FRSKSSYLRYSCESRIRSYLKEVNAHATTL......-KPQPQAEYLKIIGHMYEKLKSTRYNGSYFDRR-DKGR.......................................................................................ERLCTAEGWFSCQGPFDLD..SC..L..S..I..HSINPYSNRESRILFSTWNL.DHRIEKKRTIVPALAE.AVAK-Q...............DGREVDWEYFYNLLFTSNNLKLVHIACHKKCSHNLS.....-CDETRIYK.........
G3NPN2_GASAC/101-327             ..........a-LVEAAKGLLSDEPSPKRRKILTDLLH..N...LQDTSEVEKREDDEDWFTGV..DTR.FKTKSAYMKFNCGSRIRSYMKELDAATKTI......QRAAVRAEFLKTTKCLAEMLRSAKHNGSYFDRT-EKEA.......................................................................................HRLCTAAGWFTCQGSFDQE..VC..R..S..F..HSINPYGSRESRILFSTWNL.DHRIEKKRTIIPALLE.ALQS-H...............KSAEVNLHYFYRLLFTRDNLKLVHIVCHKKEAHHLQ.....-CDANEIF-n........
F7DWB0_ORNAN/1-179               ...........---------------------------..-...------------------GL..ESR.FKNKSGYMRYSCESRIRSYMKEVNTSASAI......-GPKAQAEYLKIIGCMGEKLKAAQYNGGYFDRR--EKR.......................................................................................ARLCTPEGWFSCQGPFDID..SC..L..S..K..HSINPYSNRESRILFSTWNL.DHIIEKKRTVVPTLAE.AVRE-Q...............DGREVDWEYFYNLLFTSENLKLVHIACHKKTSHNLS.....-CDKTRIYR.........
F1P3V6_CHICK/17-243              ..........a-VPEAARRLLEDERAPRRQRLLADLIH..Y...LSGDSAAERRDEDGKWFEGL..ESR.FKNKSSYMRYSCESRIRSYMKEVSNFISNV......-HPTARDAYKRILDLMSDKLKSVKYNGSYFDRTEEEAA.......................................................................................MRLCTKEGWFSCQGPFDRD..DC..P..C..K..HSINPYTNRESRILFSTWNL.DHIIEKKRSVVPELAE.AVKT-R...............DGREVNWEYFYQLLFTMNNLKLVHIACHKKTNHNLS.....-CDKTKIYR.........
D0AB91_9NEOP/98-350              .......ntgm----AAKEFLNVNF-KEKFKVFQKYIA.aA...NDAKTMLSERTQDPDWFEGI.iKPS.EKTKEQSMSKRVKERMRGYYYKTKSALQSSelyihsKSGRGKKLIDQFLLDLRKLLETNKYNEGYFNRK--NKN.......................................................................................FSICNEHGLFQCGGLWNSD..KC..S..YdgD..HVINPYRSREERIIFQTWNL.DHKIELSRSIVPMILE.AIKKIAqgqvhc..vlcekisNQGFIESDRYYLQLFTRENLKLVHIVCHYKGKHDAHsdvytACSKC----vg.......
B4KK42_DROMO/143-429             ...........QHPDKFRRMITEYEQQKQRRALDN---..-...--TKAHLSLKAEHVEWFEGS..EER.FQSKEEAMAVRAQTRVRGYYYKTKEELTRNpl..yrQNAKARQIINSVLEQFRYLLIGCDYFSMMFNRKCELKHemlqqhgeseepdaasvpnk...............................................rlrqvikdytsrnaildewsVSLCTDLGDFYCQGAYSDNgnYC..S..L..Q..HTINPYASRENLILFQVWNL.DHQIELCRTILPTLVA.NVQELVtqpqrk...calhnkRVVDVSVLEYFLEIFSLKNLKLVHIVCHEKVQRTNQsngrlLCADCHEYR.........
Q9NDR2_DROME/149-435             ...........QHPEKFRRMITEYEHQKQRRVLDN---..-...--SKTHLSLKAEHVEWFTGG..EER.FHSKEEAMATRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINSVLEKFRYLLIGCDFFSMMFDRNCKQKHeflkqhlgdeetdagripsk...............................................rlrqvireytkencildewsTSLCSDLGDFYCQGSYSENgnSC..S..K..Q..HTINPYASRENLILFQVWNL.DHQIELCRTILPALVA.NVEELVshpqtk...csihkkQVVDISVLEYFLEIFSLKNLKLVHIVCHEKAQRSNRsngrlLCSDCHEYR.........
Q7Q1Q3_ANOGA/111-405             ..........h-AGELAQQFVSNNQ-PEISKILFNAQR..G...RDDLIQRSAREEHAEWFEGK..KKA.AVTKEEVMKRRGQDRIRGYFYKTKDELTKCam..yrGSPMARELIDEMLELFRQLLVGFDYFSCMFDRSCQRRMelkpdtedggdepdaqripp..............................................krlkllvqsslgrgcriepynVALCSERGDFRCMGVWKDE.rCR..Y..A..S..HRINPYASRENLILFQVWNL.DHQVEISRSVLPSILD.NVERMVssadggapmcklhrrKGKNLSVITYFLELFTLSNLKLVHIVCHDKTVHELIsngtiICDRCEEYK.........
F1RJA2_PIG/1-62                  ...........---------------------------..-...--------------------..---.------------------------------......--------------------------------------.......................................................................................-------------------..--..-..-..-..--------------------.---IEKKRTVVPTLAA.AVGD-A...............EGRVVDWKYFYSLLFTLDNLKLVHVACHKKTTHRLR.....-CDPSRIYR.........
G7NTB1_MACFA/98-172              ..........g-LVQAAQQLLCDEQAPQRQRLLADLLH..N...VSQNTAAETRAEDPPWFEGL..ESR.FQNKSGYLRYSCESRIRSYLREV-------......--------------------------------------.......................................................................................-------------------..--..-..-..-..--------------------.----------------.------...............------------------------------------.....---------s........
H2V7W9_TAKRU/101-327             ..........a-IIEAAKRLLPDEPTSKRRKIMSDLLQ..N...LEDRSELETRDEDEDWFKGV..APR.FKTKSAYMRVNCESRIRGYTKELLEASKSI......EKAKVRAEFLKASKALVEMLKEAKYNGCYFDRT-GDED.......................................................................................HRLCTQEGWFTCQGAFDQD..TC..L..S..L..HSINPYSSQESRIIFSTWNL.DHRIEKRRTVIPALLR.ALEN-H...............RSSEVNLDYFYRLLFTTENLKLVHIVCHKKEAHNLP.....-CDSRKVFR.........
E2R6H2_CANFA/101-326             .........gl--IQAARQLLSDERAPLRQKLLADLLH..T...ISENIAAETRAEDPPWFEGL..ESR.FQSKSGYLRYSCESRIRSYLREVNSYAPTV......-GEEAQGEYTRIVDLMCQKLRTVQYNGSYFDRG-ARAG.......................................................................................LRLCTPEGWFCCQGPFDVD..SC..A..S..K..HSINPYGNRESRVLFSTWNL.DHIIEKKRTVVPALAE.AVTE-R...............DGREVAWEYFYSLLFTSENLKLVHIACHKKTTHKLS.....-CDPHRIYK.........
C1BZL4_ESOLU/100-326             .........li--IDAAKGLLSEEQSPKRRKLLGDLLL..H...IEDNSETENRSDDEDWFQGI..DVR.FKTKSAYMRYNCESRIRGYMKEVDSYAQTI......QKPKLKDQYRKIVECFVMQLKSDKYNGCYFNRT-EKEH.......................................................................................ERLCTKEGWFTCQGAFDQD..EC..K..S..L..HSINPYGNRESGILFSTWNL.DHRIEKKRTVLPALVE.ALHN-H...............KNSNINLDYFYNLLFTRENLKLVHIVCHKKGAHDLL.....-CDQKKIYQ.........
G6DK22_DANPL/98-353              .........nt--GKAAKEFLNVNL-KEKFKVLERYIS..A..aNDSRAMISERTQDPDWFEGL..DSS.EKTKEQSMSKRAKERMRGYYYKTKTALQSSqlyihtKNGQSKKLIDLFLLELRRRLENSKYNGDYFNRK-GSEG.......................................................................................VRLCNENGLFECGGLWNNK..KC..I..YegE..HVINPYRSREERIIFQTWNL.DHKIELSRSIIPNIQE.AIRNIIhanvkc..vmcnvssGKGHIEIDRYYLQIFTSDNLKLVHIVCHDKGKHSAEssayiLCQKC----fgnyr....
F1NYL3_CHICK/15-242              ..........a-VPEAARRLLEDERAPRRQRLLADLIH..Y...LSGDSAAERRDEDGKWFEGS.lESR.FKNKSSYMRYSCESRIRSYMKEVSNFISNV......-HPTARDAYKRILDLMSDKLKSVKYNGSYFDRTEEEAA.......................................................................................MRLCTKEGWFSCQGPFDRD..DC..P..C..K..HSINPYTNRESRILFSTWNL.DHIIEKKRSVVPELAE.AVKT-R...............DGREVNWEYFYQLLFTMNNLKLVHIACHKKTNHNLS.....-CDKTKIYR.........
H2PXW1_PANTR/143-296             ...evssypst---------------------------..-...--------------------..---.-----------------------------V......-GAEAQEEFLRVLGSMCQKLRSVQYNGSYFDRG-AKGG.......................................................................................SRLCTPEGWFSCQGPFDMD..SC..L..S..R..HSINPYSNRESRILFSTWNL.DHIIEKKRTIIPTLVE.AIKE-Q...............DGREVDWEYFYGLLFTSENLKLVHIVCHKKTTHKLN.....-CDPSRIYK.........
Q1L9C6_DANRE/100-326             .........ll--VSAAQGLLSDERSPKRRRILGDLLS..N...LRDRSELENRLQDHDWFEGI..DTR.FKTKSAYMKYNCESRIRGYLKEVDGYTQTI......QNAKTKSEYKKVAEALAEKLKAARYNGTYFDRS-EKDA.......................................................................................NRLCTEEGWFSCQGAFDEN..SC..N..F..L..HSINPYGNRESRILFSTWNL.DHLIEKKRTVIPALAK.ALEA-N...............KSNDINVDYFYKLLFTRENLKLVHIVCHKKGAHELS.....-CDSRKIYK.........
H0X4M1_OTOGA/101-326             ..........e-VIRAARQLLSGEQAPLRQKLLADLLH..N...VSQNISAETRAEDPPWFEGL..ESR.FRSKRSYLRYSCESRIRTYLREVNSSASSV......-GAEAQEEYARILGAMCEKLKSVQYNGSYFDRG-AKAS.......................................................................................SRLCTPEGWFSCQGPFDMD..NC..L..S..R..HSINPYGNRESRVLFSTWNL.DHIIEKKRTIVPTLAE.AIKE-Q...............NGREIDWEYFYSLLFTSENLKLVHIACHKKTTHKLG.....-CDPGRIYK.........
B1WBL0_XENTR/105-330             ..........c-IVEAAHKLLADEDAPKRQKLLVDFIS..N...LNENILAENRKDDESWFEGI..ESR.FKNKSSYMRYSCESRVRSYMKEVQSHTDSV......-EPVTRDEYKRIIDAMYDELRAVKYNGCYFDRT-EQKL.......................................................................................NRLCTSEGWFSCQGPFDAD..AC..S..S..R..HSINPYSNRECRILFSTWNL.DHKIEKKRTIIPCLVK.ALKE-R...............NEREVNWQYFFSLLFTKENLNLVHIACHKKTSHNLS.....-LDCSQIYR.........
Q3KZL8_DROSN/1-269               ...........QHPEKFRRMITEYEHQKQRRVLDN---..-...--SKAHLSLKAEHMEWFAGG..EER.FHSKEEAMAMRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINAVLEKFRYLLIGCDFFSMMFDRNCKQKHeflqqhlgeeetdagripsk...............................................rlrqvikeytkencildewsTSLCSDLGDFYCQGSYSENgnSC..S..K..Q..HIINPYASRENLILFQVWNL.DHQIELCRTILPALVA.NVEELVshpqik...cslhkkXVVDISVLEYFLEIFSLKNLKLVHIVCHEKV-----.....---------q........
Q3KZM4_DROSN/1-269               ...........QHPEKFRRMITEYEHQKQRRVLDN---..-...--SKAHLSLKAEHMEWFAGG..EER.FHSKEEAMAMRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINAVLEKFRYLLIGCDFFSMMFDRNCKQKHeflqqhlgeeetdagripsk...............................................rlrqvikeytkencildewsTSLCSDLGDFYCQGSYSENgnSC..S..K..Q..HIINPYASRENLILFQVWNL.DHQIELXRTILPALVA.NVEELVshpqik...cslhkkQVVDISVLEYFLEIFSLKNLKLVHIVCHEKV-----.....---------q........
DFFB_BOVIN/101-326               ..........g-VIQAARQLLWDERAPLRQKLLADLLG..T...VSENIAAETRAEDPPWFEGL..ESR.FRSKSGYLRYSCESRIRSYLREVTSGASLV......-GAEAREEYLRLVGSMQQKLQAAQYNSSYFDRG-AKAG.......................................................................................RRLCTPEGWFSCQGPFDVD..DC..T..S..R..HSINPYSNRESRVLFSTWNL.DHVIEKKRVVVPALAA.AVHD-A...............EGREVDWEYFYRLLFTLENLKLVHIACHKKTTHKLH.....-CDPSRVYC.........
Q3KZM0_DROYA/1-269               ...........QHPEKFRRMITEYEHQKQRRVLDN---..-...--SKAHLSLKAEHVEWFXGG..EER.FHSKEEAMAMRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINAVLEKFRYLLIGCDFFSMMFDRNCKQKHeflqqhlgeeetdagripsk...............................................rlrqvikeytkencildewsTSLCSDLGDFYCQGSYSENgnSC..S..K..Q..HTINPYASRENLILFQVWNL.DHQIELCRTILPALVA.NVEELVshpqik...cslhkkQVVDISVLEYFLEIFSLKNLKLVHIVCHEKA-----.....---------q........
Q17BG6_AEDAE/108-414             ..........q-AGTLVQEFVSNNQ-GEIAKLLHNAQR..S...QDEQTLKSHRSEHAEWFEGI.dEKS.GQTKEEVMQRRGQDRIRGYFYKTKDELTKCai..yrQNAMAKELIDEMLDLFRQLLSGFDFFSCIFDRSHSRRLtegavsnlvltteehkrnqgggdevda.................................primpkrmklaiekslqndgnaiekyrVALCNDRGDFSCMGLWNET.tCK..Y..E..A..HIINPYVSRENMILFQVWNL.DHQVEIRRTVLPSIVE.NLKRVIeneada..ickihnrRGKKLSVITYFIELFTLGNLKLVHIVCHDKSIHDMIskgsiICDKCAEYK.........
Q3KZM7_DROYA/1-269               ...........QHPEKFRRMITEYEHQKQRRVLDN---..-...--SKAHLSLKAEHVEWFTGG..EER.FHSKEEAMAMRAQTRVRGYYYKAKEELTRNpl..yrQNXKARQVINAVLEKFRYLLIGCDFFSMMFDRNCKQKHeflqqhlgeeetdagripsk...............................................rlrqvikeytkencildewsTSLCSDLGDFYCQGSYSENgnSC..S..K..Q..HTINPYASRENLILFQVWNL.DHQIELCRTILPALVA.NVEELVshpqik...cslhkkQVVDISVLEYFLEIFSLKNLKLVHIVCHEKA-----.....---------q........
H2MYH3_ORYLA/96-199              .........gl--IQAAKWLLCEEESFKRRKILADLLQ..N...LEDRSELESRQEDQDWFSGT..RSR.FKTKSAYMKYNCASRIRGYLKEVDLASKSI......NKAKVREEYSRAFKLLVEMLKG----------------.......................................................................................-------------------..--..-..-..-..--------------------.----------------.------...............------------------------------------.....---------d........
G7MGI5_MACMU/286-362             saavclgrswl---------------------------..-...--------------------..---.------------------------------......--------------------------------------.......................................................................................-------------------..--..-..-..-..-------------------Q.WGVIEKKRTIIPTLVE.AIKE-Q...............DGREVDWEYFYGLLFTSENLKLVHIVCHKKTIHKLN.....-CDPNRIYK.........
DFFB_HUMAN/98-323                .........gl--IQAAQQLLCDEQAPQRQRLLADLLH..N...VSQNIAAETRAEDPPWFEGL..ESR.FQSKSGYLRYSCESRIRSYLREVSSYPSTV......-GAEAQEEFLRVLGSMCQRLRSMQYNGSYFDRG-AKGG.......................................................................................SRLCTPEGWFSCQGPFDMD..SC..L..S..R..HSINPYSNRESRILFSTWNL.DHIIEKKRTIIPTLVE.AIKE-Q...............DGREVDWEYFYGLLFTSENLKLVHIVCHKKTTHKLN.....-CDPSRIYK.........
H2N9C7_PONAB/98-171              .........gl--IQAAQQLLCDEQAPQRQRLLADLLH..N...VSQNIAAETRAEDPPWFEGL..ESR.FQSKSGYLRYSCESRIRSYLRE--------......--------------------------------------.......................................................................................-------------------..--..-..-..-..--------------------.----------------.------...............------------------------------------.....---------g........
H9KHC3_APIME/104-324             ...isfttpkv-------------------AVLNNALN..K...DDSKTAYSSREEHPDWFQGL..ETN.CATKEAYLHRRCQDRIRGYLYKTIDQIKSSdv..fsKDPRARKQLLYAIAFFKMQLKEDHYFGYYFDRSRAKIGsrtg...............................................................................edtcVALCDQTGEFKCYGVWNEE..KC..LygD..R..HKINPYRSREELILFSTWNF.DHKIERSRTLIPLLLK.LATQ-G...............TANEMDLFEIYDNLFTMKNLRLVHIVCHDKGSHK--.....---------.........
DFFB_MOUSE/101-324               ..........g-VIQAARQLLSDEQAPLRQKLLADLLH..H...VSQNITAETREQDPSWFEGL..ESR.FRNKSGYLRYSCESRIRGYLREVSAYTSMV......-DEAAQEEYLRVLGSMCQKLKSVQYNGSYFDRG-AEAS.......................................................................................SRLCTPEGWFSCQGPFDLE..SC..L..S..K..HSINPYGNRESRILFSTWNL.DHIIEKKRTVVPTLAE.AIQD--...............-GREVNWEYFYSLLFTAENLKLVHIACHKKTTHKLE.....-CDRSRIYR.........
#=GR DFFB_MOUSE/101-324    SS    ..........T-THHHHHHHHHS---HHHHHHHHHHHH..H...HS--TT--BTTT-TTTTTTS..-TT.--BHHHHHHHHHHHHHHHHHHHHHGGGGGS......--TTTHHHHHHHHHHHHHHHHHGGGGGGGG-SS-S-TT.......................................................................................T-SS-TT--EE----TTSS..S-..T..T..-..-EE-GGG-HHHHHHTTTSEE.EESS-TTTTHHHHHHH.HHHH--...............-SS-B-HHHHHHHHHSTTTEEEE-GGG---S-----.....---TTTSB-.........
G1MS59_MELGA/20-246              ..........a-VLEAARKLLEDERAPRRQRLLTDLIH..N...LSGDGAAERRDEDGKWFEGL..ESR.FKNKSSYMRYSCESRIRSYMKEFSNFISNV......-HPTARDAYKRILDLMSDKLKSVKYNGSYFDRTEEEAA.......................................................................................MRLCTKEGWFSCQGPFDRD..DC..P..C..K..HSINPYTNRESRILFSTWNL.DHIIEKKRSVVPELAE.AVKT-R...............DGREVNWEYFYQLLFTLNNLKLVHIACHKKTNHNLS.....-CDKTKIYR.........
Q8UVS5_CHICK/98-324              ..........a-VVEAARRLLEDERAPRRQRLLADLIH..N...LSGDSAAERRDEDGKWFEGL..ESR.FKNKSSYMRYSCESRIRSYMKEVSNFISNV......-HPTARDAYKRILDLMSDKLKSVKYNGSYFDRTEEEAA.......................................................................................MRLCTKEGWFSCQGPFDRD..DC..P..C..K..HSINPYTNRESRILFSTWNL.DHIIEKKRSVVPELAE.AVKT-R...............DGREVNWEYFYQLLFTMNNLKLVHIACHKKTNHNLS.....-CDKTKIYR.........
Q3L0E4_DROYA/9-282               ...........QHPEKFRRMITEYEHQKQRRVLDN---..-...--SKAHLSLKAEHMEWFTGG..EER.FHSKEEAMAMRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINAVLEKFRYLLIGCDFFSMMFDRNCKQKHeflqqhlgeeetdagripsk...............................................rlrqvikeytkencildewsTSLCSDLGDFYCQGSYSENgnSC..S..K..Q..HTINPYASRENLILFQVWNL.DHQIELCRTILPALVA.NVEELVshpqik...cslhkkQVVDISVLEYFLEIFSLKNLKLVHIVCHEKAQRSN-.....---------rs.......
H3D014_TETNG/98-323              ..........a-VVKAAEDLLRDERSPKSRKVLSDLLL..N...LEDRSELETRDQDADWFRGV..GPW.FKTKSDYMKHSCRSRIRGYTREVKSS-KSI......KKAKVRKEFQKASESLEEMLKEAKYNGCYFDRS-AEEE.......................................................................................ERLCTPEGWFTCQGSFDQE..AC..S..F..F..HSINPYSSYESRIVFSTWNL.DHRIEKRRTVIPTLLG.AVER-H...............GQARVDLGYFYQLLFTTRNLKLVHIVCHKKEAHNLA.....-CDGRKLL-r........
G1R9M5_NOMLE/98-227              ......qlpqd-----TKSCLSEPAECQGLRLLDSQRE..K...SKSNVHVATSPATPPFSTGP.sERQ.QSTKSSYLGFPKLSNVP-WFLQVSSYPSTV......-GAEAQEEFLRVLGSMCQKLRSVQYNGSYFDRG-AKGG.......................................................................................GRLCTPEGWFSC-------..--..-..-..-..--------------------.----------------.------...............------------------------------------.....---------e........
A9XB03_DROTE/34-308              ...........QHPEKFRRMIMEYEHQKQRRVLDN---..-...--SKAHLSLKAEHVEWFVGG..EER.FHSKEEAMAMRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINAVLEKFRYLLIGCDFFSMMFDRNCQQKHeflqqhlgeeetdavripsk...............................................rlrqvikeytkencildewsTSLCSDLGDFYCQGSYSENgnSC..S..K..Q..HTINPYASRENLILFQVWNL.DHQIELGRTILPALVA.NVEELVshpqik...cslhkkQVVDISVLEYFLEIFSLKNLKLVHIVCHEKVQRSNR.....---------sn.......
Q3KZN0_DROYA/1-269               ...........QHPEKFRRMITEYEHQKQRRVLDN---..-...--SKAHLSLKAEHVEWFTGG..EER.FHSKEEAMAMRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINAVLEKFRYLLIGCDFFSMMFDRNCKQKHeflqqhlgeeetdagripsk...............................................rlrqvikeytkencildewsTSLCSDLGDFYCQGSYSENgnSC..S..K..Q..HTINPYASRENLILFQVWNL.DHQIELCRTILPALVA.NVEELVshpqik...cslhxkQVVDISVLEYFLEIFSLKNLKLVHIVCHEKA-----.....---------q........
Q3KZM9_DROYA/1-269               ...........QHPEKFRRMITEYEHQKQRRVLDN---..-...--SKAHLSLKAEHMEWFTGG..EER.FHSKEEAMAMRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINAVLEKFRYLLIGCDFFSMMFDRNCKQKHeflqqhlgeeetdagripsk...............................................rlrqvikeytkencildewsTSLCSDLGDFYCQGSYSENgnSC..S..K..Q..HTINPYASRENLILFQVWNL.DHQIELCRTILPALVA.NVEELVshpqik...cslxkkQVVDISVLEYFLEIFSLKNLKLVHIVCHEKA-----.....---------q........
E9ICJ0_SOLIN/1-205               ..........f---------------------------..-...--------------------..---.--SQEAYMHRRCQDRIRTYLYKTIEQIKCSdv..fmNNNKARQQLLHTIAFFKLQLKQDHYFGYYFDRSRAVTDsksesdetdydrcyehcpcnlgrgindetsylhqrlpqssdt..pvdsdnmdetdarklresrknektesdeklescpyrvkvrekqIAICDRKGEFKCEGRWNTD..GC..PygE..R..HRINPYRSKEELALFSTWNL.DHQ-------------.------...............------------------------------------.....---------.........
Q9V3H0_DROME/149-435             ...........QHPEKFRRMITEYEHQKQRRVLDN---..-...--SKTHLSLKAEHVEWFTGG..EER.FHSKEEAMATRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINSVLEKFRYLLIGCDFFSMMFDRNCKQKHeflkqhlgdeetdagripsk...............................................rlrqvireytkencildewsTSLCSDLGDFYCQGSYSENgnSC..S..K..Q..HTINPYASRENLILFQVWNL.DHQIELCRTILPALVA.NVEELVshpqtk...csihkkQVVDISVLEYFLEIFSLKNLKLVHIVCHEKAQRSNRsngrlLCSDCHEYR.........
Q3KZM3_DROSN/1-269               ...........QHPEKFRRMITEYEHQKQRRVLDN---..-...--SKAHLSLKAEHMEWFAGG..EER.FHSKEEAMAMRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINAVLEKFRYLLIGCDFFSMMFDRNCKQKHeflqqhlgeeetdagripsk...............................................rlrqvikeytkencildewsTSLCSDLGDFYCQGSYSENgnSC..S..K..Q..HIINPYASRENLILFQVWNL.DHQIELCRTILPALVA.NVEELVshpqik...cslhkkQVVDISVLEYFLEIFSLKNLKLVHIVCHEKV-----.....---------q........
F7EHI4_XENTR/105-330             ..........c-IVEAAHKLLADEDAPKRQKLLVDFIS..N...LNENILAENRKDDESWFEGI..ESR.FKNKSSYMRYSCESRVRSYMKEVQSHTDSV......-EPVTRDEYKRIIDAMYDELRAMKYNGCYFDRT-EQKL.......................................................................................NRLCTSEGWFSCQGPFDAD..AC..S..S..R..HSINPYSNRECRILFSTWNL.DHKIEKKRTIIPCLVK.ALKE-R...............NEREVNWQYFFSLLFTKENLNLVHIACHKKTSHNLS.....-LDCSQIYR.........
H0YWX9_TAEGU/98-324              ..........a-VVEAARRMLTDERAPRRQKLLADLIH..N...LSENILAEDKEDDKKWFEGL..ESR.FKNKSSYLRHSCESRMRGYMREVSGFISNV......-HPAARDAYRGIIDLMADKLKSVKYNGCYFDRREEEEA.......................................................................................ARLCTAEGWFSCQGPFDRD..DC..P..C..K..HSINPYSNRESRILFSTWNL.DHVIEKKRAVVPELAE.AVKT-R...............DEREVNWEYFYQLLFTLDNLKLVHIACHKKTNHNLS.....-CDKTRIYR.........
Q9DGL7_DANRE/100-326             .........ll--VSAAQGLLSDERSPKRRRILGDLLS..N...LRDRSELENRLQDHDWFEGI..DTR.FKTKSAYMKYNCESRIRGYLKEVDGYTQTI......KNAKTKSEYKKVAEALAEKLKAARYNGTYFDRS-EKDA.......................................................................................NRLCTEEGWFSCQGAFDEN..SC..N..F..L..HSINPYGNRESRILFSTWNL.DHLIEKKRTVIPALAK.ALEA-N...............KSNDINVDYFYKLLFTRENLKLVHIVCHKKGAHELS.....-CDSRKIYK.........
B4Q4R0_DROSI/149-435             ...........QHPEKFRRMITEYEHQKQRRVLDN---..-...--SKAHLSLKAEHVEWFTGG..EER.FHSKEEAMATRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINSVLEKFRYLLIGCDFFSMMFDRNCKQKHeflqqhlgdeetdagripsk...............................................rlrqvikeytkencildewsTSLCSDLGDFYCQGSYSENgnSC..S..K..Q..HTINPYASRENLILFQVWNL.DHQIELCRTILPALVA.NVEELVshpqtk...cslhkkQVVDISVLEYFLEIFSLKNLKLVHIVCHEKAQRSNRsngrlLCSHCHEYR.........
F6WIJ2_MACMU/98-172              ..........g-LVQAAQQLLCDEQAPQRQRLLADLLH..N...VSQNIAAETRAEDPPWFEGL..ESR.FQNKSGYLRYSCESRIRSYLREV-------......--------------------------------------.......................................................................................-------------------..--..-..-..-..--------------------.----------------.------...............------------------------------------.....---------s........
DFFB_RAT/101-324                 ..........g-VIQAARQLLSDEQAPLRQKLLADLLH..H...VSQNITAETREQDPSWFEGL..ESR.FRNKSGYLRYSCESRIRGYLREVSAYISMV......-DAAAREEYLRVLSSMCHKLKSVQYNGSYFDRG-AEAS.......................................................................................SRLCTPEGWFSCQGPFDLE..SC..L..S..K..HSINPYGNRESRILFSTWNL.DHIIEKKRTVVPTLAE.AIQD--...............-GREVNWEYFYSLLFTAENLKLVHIACHKKTTHKLQ.....-CDRSRIYR.........
Q7TS81_MOUSE/101-323             ..........g-VIQAARQLLSDEQAPLRQKLLADLLH..H...VSQNITAETREQDPSWFEGL..ESR.FRNKSGYLRYSCESRIRGYLREVSAYTSMV......-DEAAQEEYLRVLGSMCQKLKSVQYNGSYFDRG-AEAS.......................................................................................SRLCTPEGWFSCQGPFDLE..SC..L..S..K..HSINPYGNRESRILFSTWNL.DHIIEKKRTVVPTLAE.AIQD--...............-GREVNWEYFYSLLFTAENLKLVHIACHKKT-HKLE.....-CDRSRIYR.........
Q3KZL9_DROYA/1-269               ...........QHPEKFRRMITEYEHQKQRRVLDN---..-...--SKAHLSLKAEHVEWFTGG..EER.FHSKEEAMAMRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINAVLEKFRYLLIGCDFFSMMFDRNCKQKHeflqqhlgeeetdagripsk...............................................rlrqvikeytkencildewsTSLCSDLGDFYCQGSYSENgnSC..S..K..Q..HTINPYASRENLILFQVWNL.DHQIELCRTILPALVA.NVEELVshpqik...cslhkkQVVDISVLEYFLEIFSLKNLKLVHIVCHEKA-----.....---------q........
G1SEV9_RABIT/1-180               ...........---------------------------..-...------------------GL..ESR.FRSKSSYLRFSCESRIRSYLREVSSYVTWW......-ARRPEEEYLRVLGAMEQKLKSVRYNGSYFDRG-AEAG.......................................................................................SRLCTPEGWFSCQGPFDQD..GC..L..S..R..HSINPYSNRESRVLFSTWNL.DHIIEKKRTIVPTLAE.AVGA-Q...............NGREVDWEYFYGLLFTTQNLKLVHVVCHKKTTHKLS.....-CDPGRVYR.........
F6VS33_HORSE/61-285              .........gl--IQAARQLLSGELAPLRQKLLVDLLH..T...VSENIAAETRAEDPPWFEGL..ESR.FRSKSSYLRYSCESRIRGYLREVGAYSSLV......-GAEAQEEYVQIVEAMSRRLRAMSYNGSYFDRG--AKA.......................................................................................SRLCTPEGWFSCQGPFDVD..DC..V..S..K..HSINPYSNRESRVLFSTWNL.DHVIEKKRTIVPTLAE.AIKE-Q...............DGREIDWEYFYSLLFTSENLKLVHIACHKKTNHKLS.....-CDPDRIYK.........
B4IEI7_DROSE/149-435             ...........QHPEKFRRMITEYEQQKQRRVLDN---..-...--SKAHLSLKAEHVEWFTGG..EER.FHSKEEAMATRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINSVLEKFRYLLIGCDFFSMMFDRNCKQKHeflqqhlgdeetdagripsk...............................................rlrqvikeytkencildewsTSLCSDLGDFYCQGSYSENgnSC..S..K..Q..HTINPYASRENLILFQVWNL.DHQIELCRTILPALVA.NVEELVshpqtk...cslhkkQVVDISVLEYFLEIFSLKNLKLVHIVCHEKAQRSNRsngrlLCSDCHEYR.........
F4WNU5_ACREC/101-410             .........ta--GDRVTQFLTENL-KAKVALLNKVLN..K...DDSKTALSTREEHSEWFENL..ETN.CMTKEAYMHRRCQDRIRTYLYKTIEQIKCSdv..fmNDYKARQQLLHTIAFFKLQLKQDHYFGYYFDRSRAESDtksdsdetdygrcyehcpcnfgrindetylrqwylrlpqssdtnstadsdkidetdarkclaseknvktanddsescpyrvklrekqIAICNKKGEFKCEGRWNTD..GC..PygD..R..HKINPYRSKEDLVLFSTWNL.DHKIERSRTLIPKLLQ.ISRQ-D...............TINEEDIYDCYDNLFTVKNLRLVHIVCHDKGSHK--.....---------.........
B7PNY7_IXOSC/51-277              ...rsnevvaa---------LEPYKSQLIEQMLGNIESleV...PEHVLLADNKDQDPKWFEG-..EKR.ATSKRKVMRERAKTRIKGYFYKSKEDLQKC......VSENGKQCLSQLFEEFSALLRAGDHNGHYFVRG---EK.......................................................................................EALCCEKGQFLCQGTFSKP.sCD..S..R..V..HRINPYGSREQLVCFSTWNL.DHRVERSRSILPAIGK.AIEE-A...............NGRILNARYFYKLLFTTDNLKLVHPVCHIKSEHGGF.....KCERAHWY-v........
G1Q3M5_MYOLU/1-175               ...........---------------------------..-...--------------------..--R.FRNKCAYLRFSCASRIRTYLREVSSHASVV......-GAQAREEYARAVAAMAQKLRAAQYNGSYFDRG-AKGG.......................................................................................GRLCTPEGWFSCQGPFDMA..DC..A..S..R..HSINPYGSRESRVLFSTWNL.DHIIEKKRTVIPALAA.AAGA--...............AGRQVDWEYFYSLLFTCQNLKLVHIACHKKTTHGLS.....-CDPRRIYR.........
E9GG77_DAPPU/120-330             .........na---EEIVKFIEDNKDEKLKLTWQYVSK..L...PSTKSHLSSISEHPEWFSGC..NKL.VTTKEEYFRKCAQGRIRSYLRDARNRLSNN......------NLSLCPIDKFKSCLEKQKYFACYFDRK-DKSQ.......................................................................................DKLCDSKGQFQCQGQYNKT..IC..E..S..S..HQINPYDNAESRVLFSTWNL.DHVIERV-KILSDLCL.KIRC--...............-NNEFDHLKYFDLLFSKKNLKLVHKNCHVIGPH---.....---------tecqi....
B3MV75_DROAN/149-436             ...........QHPDKFRRMITEYELQKQRRVLDN---..-...--TKAHLSLKADHVEWFEGG..EER.FHSKEEAMAMRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINSVLEQFRYLLIGCDYFSMMFNRKFEQKHeflqqhqlgeeetdavsvps..............................................krlrqvikeytkensildewsVSLCTDLGDFYCQGSYSENgnCC..S..M..Q..HSINPYASRENLILFQVWNL.DHQIELCRTILPAIVA.SVEELItqphrk...cavhnkRVVDISVLEYFLEIFSLKNLRLVHIVCHEKTPRKNRsngrlLCPECHEYR.........
C3YR00_BRAFL/97-325              ..........q-LTENLEDMIAKESSPERVHALNLYLQ..S...IPDNIDAETREEDPDWFEGL..DKR.YKTKSQVMAYSAQGRIRGYFSTTKEFISNL......EDPVTKLILKRVLESFRPRLKNNGYHGDYFRRT-AKPK.......................................................................................KRLCTQAGWFVCHGPYNTK..TC..Q..E..K..HMINPYSSRQKRAAFSTWNL.DHRIEKSRSILPSMQQ.AAMSCP...............KGKQLNWEYFYELLFTTDNLKLVEISCHKKDAHKGY.....DCDEKKYY-t........
F1N2E0_BOVIN/101-326             ..........g-VIQAARQLLWDERAPLRQKLLADLLG..T...VSENIAAETRAEDPPWFEGL..ESR.FRSKSGYLRYSCESRIRSYLREVTSGASLV......-GAEAREEYLRLVGSMQQKLQAAQYNSSYFDRG-AKAG.......................................................................................RRLCTPEGWFSCQGPFDVD..DC..T..S..R..HSINPYSNRESRVLFSTWNL.DHVIEKKRVVVPALAA.AVHD-A...............EGREVDWEYFYRLLFTLENLKLVHIACHKKTTHKLH.....-CDPSRVYC.........
H9GDK6_ANOCA/101-324             ..........g-IVRAAQGLLSGEEAPKRRKLLADLIH..N...LSQNIEAESREDDEKWFQGV..ESR.FKTKSGYMRYSCESRIRSYMKEVGAYASSL......-PPSVHAKFRQIAKAMLEKLKSERYNGFYFDRR-AEKK.......................................................................................ACLCTPEGWFSCQGPFDTK..DC..P..C..R..HSINPYGNKESRILFSTWNL.DHVIEKKRTILPTLAE.ALAD--...............-RRDVDWEYFYRLLFTVSNLKLVHIACHKKTNHNLS.....-CDKRKIFR.........
Q3KZM2_DROYA/1-269               ...........QHPEKFRRMITEYEHQKQRRVLDN---..-...--SKAHLSLKAEHVEWFAGG..EER.FHSKEEAMAMRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINAVLEKFRYLLIGCDFFSMMFDRNCKQKHeflqqhlgeeetdagripsk...............................................rlrqvikeytkencildewsTSLCSDLGDFYCQGSYSENgnSC..S..K..Q..HTINPYASRENLILFQVWNL.DHQIELCRTILPALVA.NVEELVshpqik...cslhkkQVVDISVLEYFLEIFSLKNLKLVHIVCHEKA-----.....---------q........
B1AX96_MOUSE/101-324             ..........g-VIQAARQLLSDEQAPLRQKLLADLLH..H...VSQNITAETREQDPSWFEGL..ESR.FRNKSGYLRYSCESRIRGYLREVSAYTSMV......-DEAAQEEYLRVLGSMCQKLKSVQYNGSYFDRG-AEAS.......................................................................................SRLCTPEGWFSCQGPFDLE..SC..L..S..K..HSINPYGNRESRILFSTWNL.DHIIEKKRTVVPTLAE.AIQD--...............-GREVNWEYFYSLLFTAENLKLVHIACHKKTTHKLE.....-CDRSRIYR.........
B4M987_DROVI/146-432             ...........QHPDKFRRMITEYEQQKQRRALDN---..-...--TKAHLSLKAEHLEWFEGS..EER.FQSKEEAMAMRAQTRVRGYYYKTKEELTRNql..yrQNAKARQVINSVLDQFRYLLIGCDYFSMIFNRKCQLKHemlqqqvgveqpdagnvpnk...............................................rlrqiikdytsrhaildewsVSLCTDLGDFYCQGAYSDNgnNC..S..L..R..HTINPYASRENLILFQVWNL.DHQIELCRSILPALVA.NVKELVsqpqkk...calhnkRIVDISVLEYFLEIFSLKNLKLVHIVCHEKVQRTNHsngrlLCGDCHEYR.........
Q3L0E5_DROSN/9-282               ...........QHPEKFRRMITEYEHQKQRRVLDN---..-...--SKAHLSLKAEHMEWFAGG..EER.FHSKEEAMAMRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINAVLEKFRYLLIGCDFFSMMFDRNCKQKHeflqqhlgeeetdagripsk...............................................rlrqvikeytkencildewsTSLCSDLGDFYCQGSYSENgnSC..S..K..Q..HIINPYASRENLILFQVWNL.DHQIELCRTILPALVA.NVEELVshpqik...cslhkkQVVDISVLEYFLEIFSLKNLKLVHIVCHEKVQRSN-.....---------rs.......
Q3KZM8_DROYA/1-269               ...........QHPEKFRRMITEYEHQKQRRVLDN---..-...--SKAHLSLKAEHVEWFXGG..EER.FHSKEEAMAMRAQTRVRGYYYKAKEELTRNpl..yrQNAKARQVINAVLEKFRYLLIGCDFFSMMFDRNCKQKHxflqqhlgeeetdagripsk...............................................rlrqvikeytkencildewsTSLCSDLGDFYCQGSYSENgnSC..S..K..Q..HTINPYASRENLILFQVWNL.DHQIELCRTILPALVA.NVEELVshpqik...cslhkkQVVDISVLEYFLEIFSLKNLKLVHIVCHEKA-----.....---------q........
F7IAB5_CALJA/122-347             .........gl--IQAAQQLLCDERAPQRQRLLADLLH..N...ATQNIAAETRVEDPPWFEGL..ESR.FQSKSGYLRYSCESRIRSYLREVSSYPSMV......-GAEAQEEFLRVINSMCQKLRSVQYNGSYFDRG-AKGG.......................................................................................HRLCTPEGWFSCQGPFDMD..SC..L..S..R..HSINPYSNRESRILFGTWNL.DHIIEKKRAIIPTLVE.AIKD-Q...............DGREVDWEYFYGLLFTSENLKLVHIVCHKKTTHKLS.....-CDPNRIYK.........
G3W2P1_SARHA/61-286              ..........d-VIQAAQKLLSDERAPLRQKLLADFLH..N...VNENIQAESREEDGPWFEGL..ESR.FRNKSSYLRYSCESRIRSYLKEVSAYASTL......-DPKPRAEYLKIIDRMYEKLKSVHYNGSYFDRK-DKGK.......................................................................................ERLCTSEGWFSCQGPFDLD..AC..L..S..T..HSINPYSNRESRILFSTWNL.DHKIEKKRTIVPTLAE.AIAE-Q...............NGREVDWEYFYSLLFTSSNLKLVHIACHKKSCHNLS.....-CDETRIYK.........
Q29KJ1_DROPS/151-440             ...........QHPEKFRRMISDYEHQKQRLVLDN---..-...--SKAHLSLKDEHVEWFEGG..EER.FHSKEEAMAVRAQTRVRGYYYKAKEELTRNpl..yrQNPKARQVINSVLEQFRYLLIGCDYFSMMFNRKCEQKHdflqqhrqqtgdeepdagslp............................................skrlrqlikeytkqhsilddwsVSLCTDLGDFYCQGAYSDNgnCC..S..L..Q..HTINPYASRENLILFQVWNL.DHQIELSRTILPAMVA.NVEELVtkpqlk...csfhnkRVVDISVLEYFLEIFSLKNLKLVHVVCHEKVQRSNRsngrlLCPDCHEYR.........
A9XB02_DROOR/36-312              ...........QHPEKFRRMITEYEDQKQRCVLDN---..-...--SKAHLSLKDEHVEWFAGG..EER.FHSKEEAMAMRAQTRVRGYYYKAKEQLTRNpl..yrQNVRARQVINAVLEKFRYLLIGCDFFSMIFDRSCKQKHeflhqhlgeeetdagripsk...............................................rlrqvikeytkencildewsTSLCSDLGDFYCQGSFSENgnSC..S..K..Q..HTINPYASRENLILFQVWNL.DHQIELCRTILPALVA.NVEELVshpqik...csihnkKVVDISVLEYFLEIFSLKNLKLVHIVCHERVQRSNR.....---------sngr.....
G7MGI5_MACMU/98-277              .........gl--VQAAQQLLCDEQAPQRQRLLADLLH..N...VSQNIAAETRAEDPPWFEGL..ESR.FQNKSGYLRYSCESRIRSYLREVSSYPSLV......-GAEAQEEFLRVLGSMCQKLRSVQYNGSYFDRG-AKGG.......................................................................................GRLCTPEGWFSCQGPFDMD..SC..L..S..R..HSINPYSNRESRILFSTWNL.DHIV--SRAFIVALV-.------...............------------------------------------.....---------ellllc...
D6WW09_TRICA/98-327              ..........s-AGEKVQEFFTEKMKNKVFKLAEVLRG..I...DGDKAKFSLKCDHPEWFEGL..DTN.AKTKEDYMFRRAQDRIRTYFYKTREELLKE......-PTLPPNRLRSLVDELQNRLKLSKFNGHFFDRS---DN.......................................................................................KSLCDERGEFTCQGRWNKD..MClyS..P..Q..HRINPYESREGRIIFQTWNL.DHVIERSRAVIPGIVK.ALKDAEcti.........vndREASVDVKAIYNDLFTLHNLKFVHIVCHDKGRHSTK.....---------kagpy....
H3C5P7_TETNG/99-324              ..........a-VVKAAEDLLRDERSPKSRKVLSDLLL..N...LEDRSELETRDQDADWFRGV..GPW.FKTKSDYMKHSCRSRIRGYTREVKSS-KSI......KKAKVRKEFQKASESLEEMLKEAKYNGCYFDRS-AEEE.......................................................................................ERLCTPEGWFTCQGSFDQE..AC..S..F..F..HSINPYSSYESRIVFSTWNL.DHRIEKRRTVIPTLLG.AVER-H...............GQARVDLGYFYQLLFTTRNLKLVHIVCHKKEAHNLA.....-CDGRKLL-r........
Q5SR21_HUMAN/34-259              .........gl--IQAAQQLLCDEQAPQRQRLLADLLH..N...VSQNIAAETRAEDPPWFEGL..ESR.FQSKSGYLRYSCESRIRSYLREVSSYPSTV......-GAEAQEEFLRVLGSMCQRLRSMQYNGSYFDRG-AKGG.......................................................................................SRLCTPEGWFSCQGPFDMD..SC..L..S..R..HSINPYSNRESRILFSTWNL.DHIIEKKRTIIPTLVE.AIKE-Q...............DGREVDWEYFYGLLFTSENLKLVHIVCHKKTTHKLN.....-CDPSRIYK.........
H9KHC2_APIME/116-336             ...isfttpkv-------------------AVLNNALN..K...DDSKTAYSSREEHPDWFQGL..ETN.CATKEAYLHRRCQDRIRGYLYKTIDQIKSSdv..fsKDPRARKQLLYAIAFFKMQLKEDHYFGYYFDRSRAKIGsrtg...............................................................................edtcVALCDQTGEFKCYGVWNEE..KC..LygD..R..HKINPYRSREELILFSTWNF.DHKIERSRTLIPLLLK.LATQ-G...............TANEMDLFEIYDNLFTMKNLRLVHIVCHDKGSHK--.....---------.........
G3MSS0_9ACAR/1-194               ..........m---------------------------..-...------ADSREEDPKWFEG-..EKR.ATSKRAVLRERAKTRIKGYYYKSKDEMQKR.....lGDRAANGCVRHLFEEFLQILKQRDHNGHYFVRG---ET.......................................................................................DALCLSDGKFSCQGTFSRD.lCS..G..R..L..HVINPYSSREQLVLFSTWNL.DHRIERSRSILPTIVS.AIQH-A...............NGRAINVDYFFRLLFTTENLKLVHPVCHIKSEHGGF.....SCDPRNWY-a........
B0WHX2_CULQU/109-423             .........ea--GSLAKQFVSNNQ-TQIARMLEEAQR..A...QDERTAKSRRSEHAEWFEGF..DSRaGQTKEEIMQRRGQDRIRGYFYKTKDELTKCai..yrGNVMAKELIDEMLELFRHLLIGFDYFSAIFDRSHPARLpdnaevsdlvvgsgertvaaaaaaspdgqed.........................evdaqrivpkrmklaiketlekdgnaieryrVALCNSRGEFRCMGLWNER.kCK..Y..G..A..HVINPYASRENMILFQVWNL.DHQVEISRSVLPSIVQ.NVARVVakeada..vcrvhnrRGKKLSVITYFIELFTLGNLKLVHIVCHDKSIHDMIsrgaiICEKCAEYK.........
B4DZS0_HUMAN/122-347             .........gl--IQAAQQLLCDEQAPQRQRLLADLLH..N...VSQNIAAETRAEDPPWFEGL..ESR.FQSKSGYLRYSCESRIRSYLREVSSYPSTV......-GAEAQEEFLRVLGSMCQRLRSMQYNGSYFDRG-AKGG.......................................................................................SRLCTPEGWFSCQGPFDMD..SC..L..S..R..HSINPYSNRESRILFSTWNL.DHIIEKKRTIIPTLVE.AIKE-Q...............DGREVDWEYFYGLLFTSENLKLVHIVCHKKTTHKLN.....-CDPSRIYK.........
G5CBI1_HETGA/299-368             .....rvlsll---------------------------..-...--------------------..---.------------------------------......--------------------------------------.......................................................................................-------------------..--..-..-..-..--------------------.-TAIEKKRAIVPTLVD.AIQQ-R...............DGREVAWEYFYSLLFTPENLKLVHIACHKKTTHKLE.....-CDPRRIYR.........
A7RES0_NEMVE/54-282              ...........QIVDQIRDLMTGDESSEMYSVMAAFLN..Q...LQENIEAETKEDDPLWFEGV..SAS.FQTKEDAMKASAQSRIRNYFSTAKEYIEKE......GSKRSKPLLLAALSNFQQQLKKDHYFGSYFVRS-ACES.......................................................................................QRLCCSDGWFNCMGKFDSS..HC..T..K..L..HKINPYGSKEGRVLFSTWNL.DHVIEKSREILPSMVK.AAEECP...............KGKQLNWKYFYSLLFTCVNLKLVHITCHFKGEHEGQ.....VCSTKQFYE.........
#=GC SS_cons                     ..........T-THHHHHHHHHS---HHHHHHHHHHHH..H...HS--TT--BTTT-TTTTTTS..-TT.--BHHHHHHHHHHHHHHHHHHHHHGGGGGS......--TTTHHHHHHHHHHHHHHHHHGGGGGGGG-SS-S-TT.......................................................................................T-SS-TT--EE----TTSS..S-..T..T..-..-EE-GGG-HHHHHHTTTSEE.EESS-TTTTHHHHHHH.HHHH--...............-SS-B-HHHHHHHHHSTTTEEEE-GGG---S-----.....---TTTSB-.........
#=GC seq_cons                    ..........h...pthcphls-.pt.ppp+lLssh.........ppphthpp+sEcspWFcGh..EpR.F+oKpthhphpspoRlRuYhhcspp.hops.......sscA+p.h.pllpthp.hLpuscY.u.aFDRs.tptt.......................................................................................spLCospG.FpCQGsasts..sC.....p..p..HoINPYusREshILFpTWNL.DHhIEhpRTllPsLst.slcc.................pst-lsh..aa..LFThcNLKLVHIsCHcKspHp.t......Cs.pc.Yp.........
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