GenomeNet

Database: Pfam
Entry: DNA_ligase_IV
LinkDB: DNA_ligase_IV
Original site: DNA_ligase_IV 
#=GF ID   DNA_ligase_IV
#=GF AC   PF11411.3
#=GF DE   DNA ligase IV
#=GF AU   Pollington J
#=GF SE   pdb_1ik9
#=GF GA   21.20 21.20;
#=GF TC   21.20 21.90;
#=GF NC   20.80 21.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11702069
#=GF RT   Crystal structure of an Xrcc4-DNA ligase IV complex. 
#=GF RA   Sibanda BL, Critchlow SE, Begun J, Pei XY, Jackson SP, Blundell
#=GF RA   TL, Pellegrini L; 
#=GF RL   Nat Struct Biol. 2001;8:1015-1019.
#=GF DR   INTERPRO; IPR021536;
#=GF CC   DNA ligase IV along with Xrcc4 functions in DNA non-homologous
#=GF CC   end joining. This process is required to mend double-strand
#=GF CC   breaks. Upon ligase binding to an Xrcc4 dimer, the helical tails
#=GF CC   unwind leading to a flat interaction surface [1].
#=GF SQ   68
#=GS I1EAN9_AMPQE/117-152  AC I1EAN9.1
#=GS H2TKB5_TAKRU/751-786  AC H2TKB5.1
#=GS Q28EB8_XENTR/752-787  AC Q28EB8.1
#=GS G3S2K5_GORGO/749-784  AC G3S2K5.1
#=GS G5B8M6_HETGA/749-784  AC G5B8M6.1
#=GS H2R1R7_PANTR/749-784  AC H2R1R7.1
#=GS I1GES4_AMPQE/777-812  AC I1GES4.1
#=GS E9C8Y6_CAPO3/862-896  AC E9C8Y6.1
#=GS F6SA46_MONDO/749-784  AC F6SA46.1
#=GS H0VQM4_CAVPO/749-784  AC H0VQM4.1
#=GS DNLI4_PONAB/749-784   AC Q5R6L3.1
#=GS F6X700_HORSE/741-776  AC F6X700.1
#=GS Q8BTF5_MOUSE/683-718  AC Q8BTF5.1
#=GS D3B9H0_POLPA/863-898  AC D3B9H0.1
#=GS D4A0U6_RAT/749-784    AC D4A0U6.1
#=GS F1RLP1_PIG/745-780    AC F1RLP1.1
#=GS H2LGF6_ORYLA/757-792  AC H2LGF6.1
#=GS H2NKF6_PONAB/749-784  AC H2NKF6.1
#=GS B3RS92_TRIAD/748-784  AC B3RS92.1
#=GS G1MMZ0_AILME/754-789  AC G1MMZ0.1
#=GS G1R8S8_NOMLE/749-784  AC G1R8S8.1
#=GS Q4SED8_TETNG/739-774  AC Q4SED8.1
#=GS G1TA35_RABIT/749-784  AC G1TA35.1
#=GS E5S760_TRISP/464-497  AC E5S760.1
#=GS A7E283_DANRE/753-788  AC A7E283.1
#=GS DNLI4_DICDI/923-958   AC Q54CR9.1
#=GS DNLI4_MOUSE/749-784   AC Q8BTF7.1
#=GS B2AWA2_PODAN/819-849  AC B2AWA2.1
#=GS G3U8L5_LOXAF/751-786  AC G3U8L5.1
#=GS F4X7Z3_ACREC/751-786  AC F4X7Z3.1
#=GS E2A5G0_CAMFO/744-779  AC E2A5G0.1
#=GS H0XJL8_OTOGA/753-788  AC H0XJL8.1
#=GS E2R0G7_CANFA/749-784  AC E2R0G7.1
#=GS I1GES5_AMPQE/777-812  AC I1GES5.1
#=GS F1P275_CHICK/754-789  AC F1P275.1
#=GS H0ZKK3_TAEGU/748-783  AC H0ZKK3.1
#=GS G7NJL5_MACMU/749-784  AC G7NJL5.1
#=GS Q8UVU0_XENLA/752-787  AC Q8UVU0.1
#=GS H3IVL1_STRPU/690-724  AC H3IVL1.1
#=GS Q23RI5_TETTS/878-908  AC Q23RI5.1
#=GS Q533U6_MUNMU/87-122   AC Q533U6.1
#=GS G3W6K3_SARHA/731-766  AC G3W6K3.1
#=GS G4V908_SCHMA/61-95    AC G4V908.1
#=GS H9IL96_ATTCE/267-302  AC H9IL96.1
#=GS A7SKL4_NEMVE/736-771  AC A7SKL4.1
#=GS G3GTP0_CRIGR/749-784  AC G3GTP0.1
#=GS E9IXA3_SOLIN/168-203  AC E9IXA3.1
#=GS DNLI4_CHICK/754-789   AC Q90YB1.2
#=GS D2H2R3_AILME/749-784  AC D2H2R3.1
#=GS F4PGQ7_DICFS/815-850  AC F4PGQ7.1
#=GS F0ZI28_DICPU/897-932  AC F0ZI28.1
#=GS B2RBW4_HUMAN/749-784  AC B2RBW4.1
#=GS G2QBD6_THIHA/860-894  AC G2QBD6.1
#=GS G3PM28_GASAC/753-788  AC G3PM28.1
#=GS G1KPZ8_ANOCA/748-783  AC G1KPZ8.1
#=GS F1Q9E8_DANRE/753-788  AC F1Q9E8.1
#=GS G3UWC4_MOUSE/749-784  AC G3UWC4.1
#=GS F6TM13_CALJA/749-784  AC F6TM13.1
#=GS H3A217_LATCH/752-787  AC H3A217.1
#=GS Q6GLS1_XENLA/752-787  AC Q6GLS1.1
#=GS F6SN56_XENTR/752-787  AC F6SN56.1
#=GS G1Q2N1_MYOLU/749-784  AC G1Q2N1.1
#=GS H3CYB9_TETNG/751-784  AC H3CYB9.1
#=GS DNLI4_HUMAN/749-784   AC P49917.2
#=GS DNLI4_HUMAN/749-784   DR PDB; 3II6 Y; 749-784;
#=GS DNLI4_HUMAN/749-784   DR PDB; 3II6 X; 749-784;
#=GS DNLI4_HUMAN/749-784   DR PDB; 2E2W A; 103-113;
#=GS DNLI4_HUMAN/749-784   DR PDB; 1IK9 C; 755-782;
#=GS A8K8Q4_HUMAN/682-717  AC A8K8Q4.1
#=GS G7PVQ1_MACFA/749-784  AC G7PVQ1.1
#=GS F1MB07_BOVIN/749-784  AC F1MB07.2
#=GS G1NR93_MELGA/754-789  AC G1NR93.1
I1EAN9_AMPQE/117-152             .....ETASKFSEVY.DKYGDSYIDDTSE.TTLREIFDKMKD-k....
H2TKB5_TAKRU/751-786             .....STREHFAKEY.DAYGDSYFVDTDE.QQLREVFGRIRSS.....
Q28EB8_XENTR/752-787             .....STAEHFACEY.DCYGDSYITDTSE.YQLREVFHRMSN-i....
G3S2K5_GORGO/749-784             .....STKEHFAREY.DCYGDSYFIDTDL.NQLKEVFSGIKNS.....
G5B8M6_HETGA/749-784             .....STRQHFAREY.DRYGDSYFVDTDL.NQLKEVFSGIKNS.....
H2R1R7_PANTR/749-784             .....STKEHFAREY.DCYGDSYFIDTDL.NQLKEVFSGIKNS.....
I1GES4_AMPQE/777-812             .....ETASKFSEIY.DKYGDSYIHDTSE.TTLREIFDKMKD-k....
E9C8Y6_CAPO3/862-896             trvev------AKFF.DAFGDSYFEDTDE.ATLRTVFASMA--tp...
F6SA46_MONDO/749-784             .....STKEHFACEY.DCYGDSYFADTDV.VQLKEVFSRIKN-v....
H0VQM4_CAVPO/749-784             .....STKQYFAREY.DCYGDSYFVNTDL.TQLKEVFSGIKN-p....
DNLI4_PONAB/749-784              .....STKEHFAREY.DCYGDSYFVDTDL.NQLKEVFSGIKNS.....
F6X700_HORSE/741-776             .....STKEHFAREY.DCYGDSYFVDTDV.NHLKEVFSGIKN-c....
Q8BTF5_MOUSE/683-718             .....STKQHFAREY.DCYGDSYFVDTDL.DQLKEVFLGIKPS.....
D3B9H0_POLPA/863-898             .....ATRDIFSKEI.DPYGDSFTEDTDV.QTLKDAFKQIE--rq...
D4A0U6_RAT/749-784               .....STKQHFAREY.DCYGDSYFVDADL.DQLKEVFLRIKPS.....
F1RLP1_PIG/745-780               .....STKQHFARQY.DCHGDSYFVDTDV.NQLKEVFSGIKT-p....
H2LGF6_ORYLA/757-792             ....t-TREHFAKEY.DPHGDSYFLDTDG.QQLREVFGRIGD-a....
H2NKF6_PONAB/749-784             .....STKEHFAREY.DCYGDSYFVDTDL.NQLKEVFSGIKNS.....
B3RS92_TRIAD/748-784             ....k-TAEVFAKEY.DKYGDSYTKDIDNpVALKAIFDKINN-e....
G1MMZ0_AILME/754-789             .....STKEHFAREY.DHYGDSYFIDTDL.NQLKEVFSGIKNS.....
G1R8S8_NOMLE/749-784             .....STKEHFAREY.DCYGDSYFVNTDL.NELKEVFSGIKNS.....
Q4SED8_TETNG/739-774             .....STREHFAKEY.DVYGDSYFVDSDE.GQLREVFGRMRG-p....
G1TA35_RABIT/749-784             .....STKKHFALEY.DCYGDSYFVDTDL.NQLKEVFSGIKNS.....
E5S760_TRISP/464-497             ..atm--KRHFKRNF.DQYGDSYTDPVDS.ETLHD--------llttv
A7E283_DANRE/753-788             .....STREHFAKEY.DQYGDSYYVDTSE.QQLRDVIERISS-a....
DNLI4_DICDI/923-958              .....STKKRFLLDS.DQFGDSYINETTE.QSLKDSFNQIDK-l....
DNLI4_MOUSE/749-784              .....STKQHFAREY.DCYGDSYFVDTDL.DQLKEVFLGIKPS.....
B2AWA2_PODAN/819-849             ....a------AENT.DQYGDSYVRDVTP.DELRDIIDDMR--tk...
G3U8L5_LOXAF/751-786             .....STKQHFALEY.DCYGDSYFVDTDL.NQLREVFSVIKH-s....
F4X7Z3_ACREC/751-786             ....i-TRRQLTENY.DEYYDSFVVDADE.ESLKRSFDKIAK-p....
E2A5G0_CAMFO/744-779             ....k-TKHRLTENY.DEYYDNFIVDADE.ETLRRSFDKIGK-p....
H0XJL8_OTOGA/753-788             .....STKEHFAREY.DCYGDSYFVDTDL.NQLKEVFSGIRSS.....
E2R0G7_CANFA/749-784             .....STKEHFAREY.DCYGDSYFVDLDL.NQLKEVFSGIKNS.....
I1GES5_AMPQE/777-812             .....ETASKFSEIY.DKYGDSYIHDTSE.TTLREIFDKMKD-k....
F1P275_CHICK/754-789             .....ETREHFAREY.DCYGDSYTADTDV.AQLKEVFSRVKDN.....
H0ZKK3_TAEGU/748-783             ....d-TKEHFAREY.DCYGDSYTANTDV.TQLKEVFSRMKD-r....
G7NJL5_MACMU/749-784             .....STKEHFAREY.DCYGDSYFVDTDL.NQLKEVFSGIKNS.....
Q8UVU0_XENLA/752-787             .....STAEHFACEY.DCYGDSYVTDTSE.YPLRDVFHRMSKI.....
H3IVL1_STRPU/690-724             ....m--TAQFALDY.DCHGDSYTQDVNE.EKLREVFANVEK-k....
Q23RI5_TETTS/878-908             rnkll---------Y.DQYGDSYYKDVDE.DELLDILKSMK--i....
Q533U6_MUNMU/87-122              .....STKQHFAQEY.DQYGDSYFVDTDV.HQLKEVFSGIKN-a....
G3W6K3_SARHA/731-766             .....STKEHFAREY.DCYGDSYFADTDL.LQLKEVFSRIKN-v....
G4V908_SCHMA/61-95               ...sv--AAKMAQEY.DKFGDSYSEPITS.DELKFNLND----isc..
H9IL96_ATTCE/267-302             ....i-TRRQITENY.DEYYDSFVVDADE.ESLKRSFGKIAK-p....
A7SKL4_NEMVE/736-771             .....ATTAKFREEY.DRHGDSFTCDATA.DSLKTVFHNIANS.....
G3GTP0_CRIGR/749-784             .....STKQHFAREY.DCYGDSYFVDTDL.DQLKEVFLGIKK-a....
E9IXA3_SOLIN/168-203             ....i-TKHKITKNY.DEYYDNFTVYADE.ESLKRSFGKIGK-p....
DNLI4_CHICK/754-789              .....ETREHFAREY.DCYGDSYTADTDV.AQLKEVFSRVKDN.....
D2H2R3_AILME/749-784             .....STKEHFAREY.DHYGDSYFIDTDL.NQLKEVFSGIKNS.....
F4PGQ7_DICFS/815-850             ....k-TKQLLLQDI.DRFGDSFTQDTTV.DELLDSFNQITK-q....
F0ZI28_DICPU/897-932             .....STKKKFLLES.DPFGDSYFNETNF.SELKDCFNQVDK-e....
B2RBW4_HUMAN/749-784             .....STKEHFAREY.DCYGDSYFIDTDL.NQLKEVFSGIKNS.....
G2QBD6_THIHA/860-894             .mrkl------AEEStDQYGDSYARDVGV.DELRDILEQME--lp...
G3PM28_GASAC/753-788             .....STREHFAKEY.DSYGDSYVADTDE.QQLREVFGRMSG-a....
G1KPZ8_ANOCA/748-783             .....ETKQHFAREY.DCYGDSYTADVGV.AQLKEVFSRMND-l....
F1Q9E8_DANRE/753-788             .....STREHFAKEY.DQYGDSYYVDTSE.QQLRDVIERISS-a....
G3UWC4_MOUSE/749-784             .....STKQHFAREY.DCYGDSYFVDTDL.DQLKEVFLGIKPS.....
F6TM13_CALJA/749-784             .....STKEHFAREY.DCYGDSYFVDTDL.NQLKEVFSGIKNS.....
H3A217_LATCH/752-787             .....STEQHFACEY.DRYGDSFYADTAE.HQLKEVFLRISK-t....
Q6GLS1_XENLA/752-787             .....STAEHFACEY.DCYGDSYVTDTSE.YPLRDVFHRMSKI.....
F6SN56_XENTR/752-787             .....STAEHFACEY.DCYGDSYITDTSE.YQLREVFHRMSN-i....
G1Q2N1_MYOLU/749-784             .....STKQHFAREY.DCYGDSYFVDTDL.NQLKEVFSGIKDS.....
H3CYB9_TETNG/751-784             .....STREHFAKEY.DVYGDSYFVDSDE.GQLREVFGR----sa...
DNLI4_HUMAN/749-784              .....STKEHFAREY.DCYGDSYFIDTDL.NQLKEVFSGIKNS.....
#=GR DNLI4_HUMAN/749-784   SS    .....HHHHHHHHHB.-TTS-BSSS---H.HHHHHHHHCS-XX.....
A8K8Q4_HUMAN/682-717             .....STKEHFAREY.DCYGDSYFIDTDL.NQLKEVFSGIKNS.....
G7PVQ1_MACFA/749-784             .....STKEHFAREY.DCYGDSYFVDTDL.NQLKEVFSGIKNS.....
F1MB07_BOVIN/749-784             .....STKQHFAQEY.DQYGDSYFVDTDL.HQLKEVFLGIKN-a....
G1NR93_MELGA/754-789             ....d-TKEHFAREY.DCYGDSYTADTDV.AQLKEVFSRVKDN.....
#=GC SS_cons                     .....HHHHHHHHHB.-TTS-BSSS---H.HHHHHHHHCS-XX.....
#=GC seq_cons                    .....ST+cHFA+EY.DsYGDSYasDTDh.sQLKEVFstI+s......
//
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