GenomeNet

Database: Pfam
Entry: DNA_ligase_IV
LinkDB: DNA_ligase_IV
Original site: DNA_ligase_IV 
#=GF ID   DNA_ligase_IV
#=GF AC   PF11411.4
#=GF DE   DNA ligase IV
#=GF AU   Pollington J
#=GF SE   pdb_1ik9
#=GF GA   21.20 21.20;
#=GF TC   21.20 21.30;
#=GF NC   21.10 21.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11702069
#=GF RT   Crystal structure of an Xrcc4-DNA ligase IV complex. 
#=GF RA   Sibanda BL, Critchlow SE, Begun J, Pei XY, Jackson SP, Blundell
#=GF RA   TL, Pellegrini L; 
#=GF RL   Nat Struct Biol. 2001;8:1015-1019.
#=GF DR   INTERPRO; IPR021536;
#=GF CC   DNA ligase IV along with Xrcc4 functions in DNA non-homologous
#=GF CC   end joining. This process is required to mend double-strand
#=GF CC   breaks. Upon ligase binding to an Xrcc4 dimer, the helical tails
#=GF CC   unwind leading to a flat interaction surface [1].
#=GF SQ   172
#=GS G1TA35_RABIT/750-783      AC G1TA35.1
#=GS G4V908_SCHMA/63-93        AC G4V908.1
#=GS U6CR64_NEOVI/750-783      AC U6CR64.1
#=GS A0A024SHB3_HYPJE/836-863  AC A0A024SHB3.1
#=GS K9J362_DESRO/750-783      AC K9J362.1
#=GS G3GTP0_CRIGR/750-783      AC G3GTP0.1
#=GS G6DJA3_DANPL/1164-1197    AC G6DJA3.1
#=GS L7M031_9ACAR/757-790      AC L7M031.1
#=GS U6GJ55_EIMAC/884-910      AC U6GJ55.1
#=GS K9GB89_PEND1/796-827      AC K9GB89.1
#=GS Q23RI5_TETTS/880-907      AC Q23RI5.1
#=GS I1GES5_AMPQE/778-811      AC I1GES5.1
#=GS M0WXP7_HORVD/289-322      AC M0WXP7.1
#=GS H3CYB9_TETNG/752-783      AC H3CYB9.1
#=GS V9FEY5_PHYPR/799-827      AC V9FEY5.1
#=GS I3NG11_SPETR/750-783      AC I3NG11.1
#=GS W4YR11_STRPU/691-723      AC W4YR11.1
#=GS F6TM13_CALJA/750-783      AC F6TM13.1
#=GS H2NKF6_PONAB/750-783      AC H2NKF6.1
#=GS W3WI38_9PEZI/834-864      AC W3WI38.1
#=GS B2AWA2_PODAN/817-847      AC B2AWA2.1
#=GS L8I3H6_9CETA/755-788      AC L8I3H6.1
#=GS M3Z4P4_MUSPF/750-783      AC M3Z4P4.1
#=GS D0MXT4_PHYIT/803-833      AC D0MXT4.1
#=GS F4X7Z3_ACREC/752-785      AC F4X7Z3.1
#=GS B3RS92_TRIAD/749-783      AC B3RS92.1
#=GS A8K8Q4_HUMAN/683-716      AC A8K8Q4.1
#=GS A0E0N5_PARTE/4-32         AC A0E0N5.1
#=GS U6KFF2_9EIME/16-42        AC U6KFF2.1
#=GS K3WBD5_PYTUL/805-838      AC K3WBD5.1
#=GS W6Q914_PENRO/821-853      AC W6Q914.1
#=GS M0WXP8_HORVD/627-660      AC M0WXP8.1
#=GS H2LGF6_ORYLA/758-791      AC H2LGF6.1
#=GS F1P275_CHICK/755-788      AC F1P275.1
#=GS G3S2K5_GORGO/750-783      AC G3S2K5.1
#=GS W9VK48_9EURO/913-945      AC W9VK48.1
#=GS I1PPI3_ORYGL/709-742      AC I1PPI3.1
#=GS V4CSZ7_LOTGI/757-790      AC V4CSZ7.1
#=GS M3XAQ1_FELCA/750-783      AC M3XAQ1.1
#=GS W9Y3F1_9EURO/854-886      AC W9Y3F1.1
#=GS G0QW01_ICHMG/777-803      AC G0QW01.1
#=GS I7GI79_MACFA/8-41         AC I7GI79.1
#=GS W2LDA3_PHYPR/799-827      AC W2LDA3.1
#=GS J9JYG2_ACYPI/743-772      AC J9JYG2.2
#=GS W2S946_9EURO/834-866      AC W2S946.1
#=GS B9FCD0_ORYSJ/773-806      AC B9FCD0.1
#=GS A7SKL4_NEMVE/737-770      AC A7SKL4.1
#=GS F1MB07_BOVIN/750-783      AC F1MB07.2
#=GS M4AL27_XIPMA/755-788      AC M4AL27.1
#=GS K7J781_NASVI/776-809      AC K7J781.1
#=GS T1G253_HELRO/764-796      AC T1G253.1
#=GS G2QBD6_THIHA/860-892      AC G2QBD6.1
#=GS DNLI4_DICDI/924-957       AC Q54CR9.1
#=GS T2MFF1_HYDVU/749-782      AC T2MFF1.1
#=GS N6TVZ2_DENPD/715-739      AC N6TVZ2.1
#=GS M2N1Y8_BAUCO/808-840      AC M2N1Y8.1
#=GS K9G0M2_PEND2/796-827      AC K9G0M2.1
#=GS F4PGQ7_DICFS/816-849      AC F4PGQ7.1
#=GS D4A0U6_RAT/750-783        AC D4A0U6.1
#=GS U3DW47_CALJA/750-783      AC U3DW47.1
#=GS G3W6K3_SARHA/732-765      AC G3W6K3.1
#=GS G1NR93_MELGA/755-788      AC G1NR93.1
#=GS G1KPZ8_ANOCA/749-782      AC G1KPZ8.1
#=GS F6X700_HORSE/742-775      AC F6X700.1
#=GS H6BN77_EXODN/861-893      AC H6BN77.1
#=GS DNLI4_PONAB/750-783       AC Q5R6L3.1
#=GS R7YQF8_CONA1/836-866      AC R7YQF8.1
#=GS H2TKB5_TAKRU/752-785      AC H2TKB5.1
#=GS K3Y4S0_SETIT/710-743      AC K3Y4S0.1
#=GS S3BUX2_OPHP1/891-919      AC S3BUX2.1
#=GS S9XMP9_9CETA/683-716      AC S9XMP9.1
#=GS R7UVV7_CAPTE/745-778      AC R7UVV7.1
#=GS H0VQM4_CAVPO/750-783      AC H0VQM4.1
#=GS F6SA46_MONDO/750-783      AC F6SA46.1
#=GS U3I1H5_ANAPL/721-754      AC U3I1H5.1
#=GS G7NJL5_MACMU/750-783      AC G7NJL5.1
#=GS S7NQV6_MYOBR/753-786      AC S7NQV6.1
#=GS X6MLA4_RETFI/449-482      AC X6MLA4.1
#=GS Q01KE4_ORYSA/732-765      AC Q01KE4.1
#=GS G1X6G5_ARTOA/796-823      AC G1X6G5.1
#=GS E9C8Y6_CAPO3/862-895      AC E9C8Y6.1
#=GS W2QEC0_PHYPN/799-827      AC W2QEC0.1
#=GS L2G8K7_COLGN/835-863      AC L2G8K7.1
#=GS S4NLZ5_9NEOP/8-41         AC S4NLZ5.1
#=GS G3PM28_GASAC/754-787      AC G3PM28.1
#=GS U4UGE6_DENPD/704-728      AC U4UGE6.1
#=GS U3BRS6_CALJA/750-783      AC U3BRS6.1
#=GS W5B7I6_WHEAT/746-779      AC W5B7I6.1
#=GS V9D3J0_9EURO/917-949      AC V9D3J0.1
#=GS M3C742_SPHMS/711-743      AC M3C742.1
#=GS V5FLX0_BYSSN/829-861      AC V5FLX0.1
#=GS V8NTK3_OPHHA/753-786      AC V8NTK3.1
#=GS H2R1R7_PANTR/750-783      AC H2R1R7.1
#=GS Q6GLS1_XENLA/753-786      AC Q6GLS1.1
#=GS T0JS13_COLGC/835-863      AC T0JS13.1
#=GS G5B8M6_HETGA/750-783      AC G5B8M6.1
#=GS C1LG27_SCHJA/202-233      AC C1LG27.1
#=GS R8BCR9_TOGMI/833-865      AC R8BCR9.1
#=GS G0REV3_HYPJQ/800-827      AC G0REV3.1
#=GS Q8BTF5_MOUSE/684-717      AC Q8BTF5.1
#=GS Q8UVU0_XENLA/753-786      AC Q8UVU0.1
#=GS A0A024JMI7_GEOCN/775-802  AC A0A024JMI7.1
#=GS W2J9D8_PHYPR/799-827      AC W2J9D8.1
#=GS R0JQQ7_ANAPL/720-753      AC R0JQQ7.1
#=GS G1R8S8_NOMLE/750-783      AC G1R8S8.1
#=GS S8CUB9_9LAMI/745-777      AC S8CUB9.1
#=GS W5ASW8_WHEAT/390-423      AC W5ASW8.1
#=GS K1RAZ9_CRAGI/457-492      AC K1RAZ9.1
#=GS E2BTB8_HARSA/750-778      AC E2BTB8.1
#=GS U3JNN2_FICAL/755-788      AC U3JNN2.1
#=GS F1RLP1_PIG/749-782        AC F1RLP1.2
#=GS A0A015JCI6_9GLOM/276-307  AC A0A015JCI6.1
#=GS U6LHJ7_9EIME/363-389      AC U6LHJ7.1
#=GS DNLI4_MOUSE/750-783       AC Q8BTF7.2
#=GS A0A022PR34_MIMGU/747-780  AC A0A022PR34.1
#=GS U9UHK1_RHIID/755-786      AC U9UHK1.1
#=GS B2RBW4_HUMAN/750-783      AC B2RBW4.1
#=GS W2X8B2_PHYPR/799-827      AC W2X8B2.1
#=GS B7QI11_IXOSC/745-777      AC B7QI11.1
#=GS H3A217_LATCH/753-786      AC H3A217.1
#=GS G3U8L5_LOXAF/752-785      AC G3U8L5.1
#=GS DNLI4_ORYSJ/774-806       AC Q7X7E9.2
#=GS E9IXA3_SOLIN/169-202      AC E9IXA3.1
#=GS D3B9H0_POLPA/864-897      AC D3B9H0.1
#=GS Q4SED8_TETNG/740-772      AC Q4SED8.1
#=GS J3M165_ORYBR/362-395      AC J3M165.1
#=GS F0ZI28_DICPU/898-931      AC F0ZI28.1
#=GS E2R0G7_CANFA/750-783      AC E2R0G7.1
#=GS E3Q270_COLGM/823-854      AC E3Q270.1
#=GS A7E283_DANRE/754-787      AC A7E283.1
#=GS A0A024RE06_HUMAN/750-783  AC A0A024RE06.1
#=GS W5MR27_LEPOC/765-798      AC W5MR27.1
#=GS F6SN56_XENTR/753-786      AC F6SN56.1
#=GS E5S760_TRISP/467-493      AC E5S760.1
#=GS C5YFJ3_SORBI/694-727      AC C5YFJ3.1
#=GS M7CF39_CHEMY/754-787      AC M7CF39.1
#=GS M0WXP9_HORVD/141-174      AC M0WXP9.1
#=GS W9Y2V3_9EURO/903-933      AC W9Y2V3.1
#=GS G1Q2N1_MYOLU/750-783      AC G1Q2N1.1
#=GS W5C1K1_WHEAT/628-661      AC W5C1K1.1
#=GS I1GES4_AMPQE/778-811      AC I1GES4.1
#=GS DNLI4_HUMAN/750-783       AC P49917.2
#=GS DNLI4_HUMAN/750-783       DR PDB; 3II6 X; 750-783;
#=GS DNLI4_HUMAN/750-783       DR PDB; 2E2W A; 104-113;
#=GS DNLI4_HUMAN/750-783       DR PDB; 1IK9 C; 755-782;
#=GS DNLI4_HUMAN/750-783       DR PDB; 3II6 Y; 750-783;
#=GS I1EAN9_AMPQE/118-151      AC I1EAN9.1
#=GS S4RIR1_PETMA/473-506      AC S4RIR1.1
#=GS W2ZHX1_PHYPR/799-827      AC W2ZHX1.1
#=GS Q28EB8_XENTR/753-786      AC Q28EB8.1
#=GS H0ZKK3_TAEGU/749-782      AC H0ZKK3.1
#=GS DNLI4_CHICK/755-788       AC Q90YB1.2
#=GS W4W9D9_ATTCE/268-301      AC W4W9D9.1
#=GS W5KLF1_ASTMX/809-842      AC W5KLF1.1
#=GS A0A026WQU9_CERBI/753-786  AC A0A026WQU9.1
#=GS Q7QFQ8_ANOGA/742-766      AC Q7QFQ8.4
#=GS G1MMZ0_AILME/755-788      AC G1MMZ0.1
#=GS T1JBC6_STRMM/750-783      AC T1JBC6.1
#=GS N1PYV5_MYCP1/819-847      AC N1PYV5.1
#=GS E2A5G0_CAMFO/745-778      AC E2A5G0.1
#=GS L9JAZ9_TUPCH/683-716      AC L9JAZ9.1
#=GS D2H2R3_AILME/750-783      AC D2H2R3.1
#=GS H0XJL8_OTOGA/754-787      AC H0XJL8.1
#=GS W1PY88_AMBTC/758-791      AC W1PY88.1
#=GS I1J1I5_BRADI/732-765      AC I1J1I5.1
#=GS L5LFH6_MYODS/860-893      AC L5LFH6.1
#=GS Q533U6_MUNMU/88-121       AC Q533U6.1
#=GS M0WXP5_HORVD/399-432      AC M0WXP5.1
#=GS I3K1S4_ORENI/766-799      AC I3K1S4.1
#=GS U6MY78_9EIME/919-947      AC U6MY78.1
#=GS K7F0E0_PELSI/754-787      AC K7F0E0.1
#=GS F1Q9E8_DANRE/754-787      AC F1Q9E8.1
#=GS B8ATU5_ORYSI/773-806      AC B8ATU5.1
#=GS K1R0N9_CRAGI/755-788      AC K1R0N9.1
#=GS L5KU26_PTEAL/750-783      AC L5KU26.1
#=GS G7PVQ1_MACFA/750-783      AC G7PVQ1.1
G1TA35_RABIT/750-783                 ......TKKHFALEY.DCYGD..SYFVDTDLN.QLKEVFSGIKN......
G4V908_SCHMA/63-93                   .....a--AKMAQEY.DKFGD..SYSEPITSD.ELK--------fnlndi
U6CR64_NEOVI/750-783                 ......TKEHFAREY.DCYGD..SYFVDTDLN.RLKEVFSGIK-s.....
A0A024SHB3_HYPJE/836-863             ..aeva-----AQNT.DRYGD..SYARDVDVE.ELRE-------lm....
K9J362_DESRO/750-783                 ......TKQHFAREY.DCYGD..SYFVDTDLN.QLKEVFTGIK-s.....
G3GTP0_CRIGR/750-783                 ......TKQHFAREY.DCYGD..SYFVDTDLD.QLKEVFLGIKK......
G6DJA3_DANPL/1164-1197               ......TKLKLSLDY.DPFGD..SYKDEIDEK.TLKKLLDKMD-s.....
L7M031_9ACAR/757-790                 ......TENRLKDLF.DEYGD..SYTVPVTPS.SLCEIFAAIP-k.....
U6GJ55_EIMAC/884-910                 ......-KRQLQQNY.DIYGD..SYLEDTTPN.EL---------eha...
K9GB89_PEND1/796-827                 .eevva-------NV.DQFMD..SYARDTTVE.ELKEVFKQME-q.....
Q23RI5_TETTS/880-907                 ...kll--------Y.DQYGD..SYYKDVDED.ELLDILK----smk...
I1GES5_AMPQE/778-811                 ......TASKFSEIY.DKYGD..SYIHDTSET.TLREIFDKMK-d.....
M0WXP7_HORVD/289-322                 .....a-RHKFPEEI.DLYAD..FYYWDIDVS.DLKQIFINMDK......
H3CYB9_TETNG/752-783                 ......TREHFAKEY.DVYGD..SYFVDSDEG.QLREVFGR---s.....
V9FEY5_PHYPR/799-827                 ......-RELLAKEY.DRYGD..HFTEHITPD.NLQRI------lr....
I3NG11_SPETR/750-783                 ......TKQHFAREY.DPYGD..SYFVDTDLN.LLKEVFSGIKN......
W4YR11_STRPU/691-723                 .....t--AQFALDY.DCHGD..SYTQDVNEE.KLREVFANVEK......
F6TM13_CALJA/750-783                 ......TKEHFAREY.DCYGD..SYFVDTDLN.QLKEVFSGIKN......
H2NKF6_PONAB/750-783                 ......TKEHFAREY.DCYGD..SYFVDTDLN.QLKEVFSGIKN......
W3WI38_9PEZI/834-864                 .....k--EQAQENL.DDYGD..SYARDIDVA.ELKA-------llqdm.
B2AWA2_PODAN/817-847                 ...kla-----AENT.DQYGD..SYVRDVTPD.ELRDI------iddmr.
L8I3H6_9CETA/755-788                 ......TKQHFAQEY.DQYRD..SYFVDTDLH.QLKEVFLGIKN......
M3Z4P4_MUSPF/750-783                 ......TKEHFAREY.DCYGD..SYFVDTDLN.RLKEVFSGIKN......
D0MXT4_PHYIT/803-833                 ......-RQLLAKEY.DRYGD..HFTEHVTPD.DLRRI------lqel..
F4X7Z3_ACREC/752-785                 ......TRRQLTENY.DEYYD..SFVVDADEE.SLKRSFDKIAK......
B3RS92_TRIAD/749-783                 ......TAEVFAKEY.DKYGD..SYTKDIDNPvALKAIFDKINN......
A8K8Q4_HUMAN/683-716                 ......TKEHFAREY.DCYGD..SYFIDTDLN.QLKEVFSGIKN......
A0E0N5_PARTE/4-32                    ..vnkf--------Y.DKFGD..SYFELIDEF.ALKDICDNMK-......
U6KFF2_9EIME/16-42                   .....q--QQLQQAF.DMYGD..SFYKDTTPS.ELK--------ya....
K3WBD5_PYTUL/805-838                 ......TRALLAKEY.DQFGD..HFTEYVKPD.DLRLIFKEV--ar....
W6Q914_PENRO/821-853                 ...eee----VTANV.DKFMD..SYARDTTVD.ELKDVFKQME-q.....
M0WXP8_HORVD/627-660                 .....a-RHKFPEEI.DLYAD..FYYWDIDVS.DLKQIFINMDK......
H2LGF6_ORYLA/758-791                 ......TREHFAKEY.DPHGD..SYFLDTDGQ.QLREVFGRIG-d.....
F1P275_CHICK/755-788                 ......TREHFAREY.DCYGD..SYTADTDVA.QLKEVFSRVK-d.....
G3S2K5_GORGO/750-783                 ......TKEHFAREY.DCYGD..SYFIDTDLN.QLKEVFSGIKN......
W9VK48_9EURO/913-945                 .....r--DRLGDNA.DEYGD..SYARDTSED.ELREIMDKMG-s.....
I1PPI3_ORYGL/709-742                 .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
V4CSZ7_LOTGI/757-790                 ......TQRKFDEDY.DVYGD..SYYTDTQED.QLKHVFDKMEK......
M3XAQ1_FELCA/750-783                 ......TKQHFAREY.DCYGD..SYFIDTDLN.QLKEVFSGIKN......
W9Y3F1_9EURO/854-886                 ......-RDRFADNV.DEYGD..SYARDTSVD.ELSKCMDRM--vd....
G0QW01_ICHMG/777-803                 ....al--------Y.DKYGD..PYFKEIDVE.ELRDILENM--s.....
I7GI79_MACFA/8-41                    ......TKEHFAREY.DCYGD..SYFVDTDLN.QLKEVFSGIKN......
W2LDA3_PHYPR/799-827                 ......-RELLAKEY.DRYGD..HFTEHITPD.NLQRI------lr....
J9JYG2_ACYPI/743-772                 ...lmd------EKF.DQYGD..SYTELATVE.TLRRAMDRV--e.....
W2S946_9EURO/834-866                 ...dep----FEWNI.DKYGD..PYYRDTGVE.ELRDVFKKMT-s.....
B9FCD0_ORYSJ/773-806                 .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
A7SKL4_NEMVE/737-770                 ......TTAKFREEY.DRHGD..SFTCDATAD.SLKTVFHNIAN......
F1MB07_BOVIN/750-783                 ......TKQHFAQEY.DQYGD..SYFVDTDLH.QLKEVFLGIKN......
M4AL27_XIPMA/755-788                 ......TREHFAKEY.DSYGD..SYFVDTDEQ.QLREVFSRID-g.....
K7J781_NASVI/776-809                 ......TRRKLDDAY.DQYWD..NYTEDLDEE.TLKRVTKRIE-e.....
T1G253_HELRO/764-796                 ......TRQKFADDY.DGYGD..EYFCPTSPQ.QLKCLFDGI--q.....
G2QBD6_THIHA/860-892                 ....mr---KLAEEStDQYGD..SYARDVGVD.ELRDILEQME-......
DNLI4_DICDI/924-957                  ......TKKRFLLDS.DQFGD..SYINETTEQ.SLKDSFNQIDK......
T2MFF1_HYDVU/749-782                 ..tlal----LEVDF.DKFGD..HYLEDINPS.TLSDIFSHMN-a.....
N6TVZ2_DENPD/715-739                 clsdat---------.DRYGD..SYTQEATME.TLKHS------......
M2N1Y8_BAUCO/808-840                 ...agk----FDDAV.DEYGD..SYARDATPD.ELLTLFNRM--ps....
K9G0M2_PEND2/796-827                 .eevva-------NV.DQFMD..SYARDTTVE.ELKEVFKQME-q.....
F4PGQ7_DICFS/816-849                 ......TKQLLLQDI.DRFGD..SFTQDTTVD.ELLDSFNQITK......
D4A0U6_RAT/750-783                   ......TKQHFAREY.DCYGD..SYFVDADLD.QLKEVFLRIK-p.....
U3DW47_CALJA/750-783                 ......TKEHFAREY.DCYGD..SYFVDTDLN.QLKEVFSGIKN......
G3W6K3_SARHA/732-765                 ......TKEHFAREY.DCYGD..SYFADTDLL.QLKEVFSRIKN......
G1NR93_MELGA/755-788                 ......TKEHFAREY.DCYGD..SYTADTDVA.QLKEVFSRVK-d.....
G1KPZ8_ANOCA/749-782                 ......TKQHFAREY.DCYGD..SYTADVGVA.QLKEVFSRMN-d.....
F6X700_HORSE/742-775                 ......TKEHFAREY.DCYGD..SYFVDTDVN.HLKEVFSGIKN......
H6BN77_EXODN/861-893                 ......-KDRYADNV.DQYGD..SFARDTSVD.ELSRCMDQMG-d.....
DNLI4_PONAB/750-783                  ......TKEHFAREY.DCYGD..SYFVDTDLN.QLKEVFSGIKN......
R7YQF8_CONA1/836-866                 ...qie------ANV.DEYGD..SFAQDVTVN.ELRRIFKGMS-s.....
H2TKB5_TAKRU/752-785                 ......TREHFAKEY.DAYGD..SYFVDTDEQ.QLREVFGRIR-s.....
K3Y4S0_SETIT/710-743                 .....a-RHKFPEEI.DSYAD..YYYWDIDIA.DLKQIFSNIDK......
S3BUX2_OPHP1/891-919                 ....eh-------NT.DEYGD..SFARDVSVA.ELKEIFSKMD-t.....
S9XMP9_9CETA/683-716                 ......TREHFAREY.DCYGD..SYFVDTDLN.QLKEVFSGIK-d.....
R7UVV7_CAPTE/745-778                 ......TKARFSAEY.DSFGD..SFFNDTSVE.ELRETFTHVN-q.....
H0VQM4_CAVPO/750-783                 ......TKQYFAREY.DCYGD..SYFVNTDLT.QLKEVFSGIKN......
F6SA46_MONDO/750-783                 ......TKEHFACEY.DCYGD..SYFADTDVV.QLKEVFSRIKN......
U3I1H5_ANAPL/721-754                 ......TKEHFAREY.DCYGD..SYTADTDVA.QLKEVFSRMK-d.....
G7NJL5_MACMU/750-783                 ......TKEHFAREY.DCYGD..SYFVDTDLN.QLKEVFSGIKN......
S7NQV6_MYOBR/753-786                 ......TKQHFAREY.DCYGD..SYFVDTDLN.QLKEVFSGIK-d.....
X6MLA4_RETFI/449-482                 ......TKKNLQKDY.DRFGD..HYLQYATVD.TLNSIFTKID-l.....
Q01KE4_ORYSA/732-765                 .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
G1X6G5_ARTOA/796-823                 .....s-KDKFEETI.DPYGD..SYYRDTTAE.DL---------skl...
E9C8Y6_CAPO3/862-895                 ......TRVEVAKFF.DAFGD..SYFEDTDEA.TLRTVFASMA-t.....
W2QEC0_PHYPN/799-827                 ......-RELLAKEY.DRYGD..HFTEHITPD.NLQRI------lr....
L2G8K7_COLGN/835-863                 ....iq-------NT.DMYGD..SYARDISVD.ELRQVFKEV--pk....
S4NLZ5_9NEOP/8-41                    ......TKFSLCLEY.DTFGD..SYKEELDEN.TLRKCMTKMD-r.....
G3PM28_GASAC/754-787                 ......TREHFAKEY.DSYGD..SYVADTDEQ.QLREVFGRMS-g.....
U4UGE6_DENPD/704-728                 clsdat---------.DRYGD..SYTQEATME.TLKHS------......
U3BRS6_CALJA/750-783                 ......TKEHFAREY.DCYGD..SYFVDTDLN.QLKEVFSGIKN......
W5B7I6_WHEAT/746-779                 .....a-RHKFPEEI.DSYAD..FYYWDIDVS.DLKQIFINMDK......
V9D3J0_9EURO/917-949                 ......-KDRFEGNV.DEYGD..SYARDTSED.ELREIMNKMG-s.....
M3C742_SPHMS/711-743                 ....eg---KFDDNV.DEFGD..SYARDVTAQ.DLLALFKEM--pt....
V5FLX0_BYSSN/829-861                 ......-KEVISQNV.DPFGD..SYARDTSVE.ELREIFNRMK-a.....
V8NTK3_OPHHA/753-786                 ......TKQHFACEY.DTYGD..SFTADTDPV.ELKAVFSRIN-t.....
H2R1R7_PANTR/750-783                 ......TKEHFAREY.DCYGD..SYFIDTDLN.QLKEVFSGIKN......
Q6GLS1_XENLA/753-786                 ......TAEHFACEY.DCYGD..SYVTDTSEY.PLRDVFHRMSK......
T0JS13_COLGC/835-863                 ....iq-------NT.DMYGD..SYARDIGVD.ELRQVFKEV--pk....
G5B8M6_HETGA/750-783                 ......TRQHFAREY.DRYGD..SYFVDTDLN.QLKEVFSGIKN......
C1LG27_SCHJA/202-233                 .....a--ARMALEY.DKFGD..SYSEFTTPD.ELKLIFDDIS-......
R8BCR9_TOGMI/833-865                 akiaen-------NT.DQYGD..SYARDAEVE.ELREILANM--pk....
G0REV3_HYPJQ/800-827                 ..aeva-----AQNT.DRYGD..SYARDVDVE.ELRE-------lm....
Q8BTF5_MOUSE/684-717                 ......TKQHFAREY.DCYGD..SYFVDTDLD.QLKEVFLGIK-p.....
Q8UVU0_XENLA/753-786                 ......TAEHFACEY.DCYGD..SYVTDTSEY.PLRDVFHRMSK......
A0A024JMI7_GEOCN/775-802             .....k------KNV.DKYGD..SYYEDIHPT.ELRSLMKRM--t.....
W2J9D8_PHYPR/799-827                 ......-RELLAKEY.DRYGD..HFTEHITPD.NLQRI------lr....
R0JQQ7_ANAPL/720-753                 ......TKEHFAREY.DCYGD..SYTADTDVA.QLKEVFSRMK-d.....
G1R8S8_NOMLE/750-783                 ......TKEHFAREY.DCYGD..SYFVNTDLN.ELKEVFSGIKN......
S8CUB9_9LAMI/745-777                 ......-RKKFEGEI.DEFSD..SFYSDINAT.ELKQILGNID-e.....
W5ASW8_WHEAT/390-423                 .....a-RHKFPEEI.DSYAD..FYYWDIDVS.DLKQIFINMDK......
K1RAZ9_CRAGI/457-492                 ......TQMALKKDY.DKFGDtcSYMQDTTPD.QLKYTFQHMDN......
E2BTB8_HARSA/750-778                 ....sm-------EY.DIYYD..YYYIDATAS.TLQHSFARID-e.....
U3JNN2_FICAL/755-788                 ......TKEHFAREY.DCYGD..SYTANTDVA.QLREVFSRMK-d.....
F1RLP1_PIG/749-782                   ......TKQHFARQY.DCHGD..SYFVDTDVN.QLKEVFSGIK-t.....
A0A015JCI6_9GLOM/276-307             ......TKQEFLTRM.DEWGD..SYTDEVTIE.DLQETFD----lm....
U6LHJ7_9EIME/363-389                 .....q--QQLQQNF.DVYGD..SYYEDTSPN.ELRH-------a.....
DNLI4_MOUSE/750-783                  ......TKQHFAREY.DCYGD..SYFVDTDLD.QLKEVFLGIK-p.....
A0A022PR34_MIMGU/747-780             .....s-KKKLEEEI.DEFSD..SYYMDLNVA.DLKQILSNVDK......
U9UHK1_RHIID/755-786                 ......TKQEFLTRM.DEWGD..SYTDEVTIE.DLQETFD----lm....
B2RBW4_HUMAN/750-783                 ......TKEHFAREY.DCYGD..SYFIDTDLN.QLKEVFSGIKN......
W2X8B2_PHYPR/799-827                 ......-RELLAKEY.DRYGD..HFTEHITPD.NLQRI------lr....
B7QI11_IXOSC/745-777                 ......TERRLKAAF.DEWGD..SYTVPVTAE.SLRDLFEAI--p.....
H3A217_LATCH/753-786                 ......TEQHFACEY.DRYGD..SFYADTAEH.QLKEVFLRISK......
G3U8L5_LOXAF/752-785                 ......TKQHFALEY.DCYGD..SYFVDTDLN.QLREVFSVIK-h.....
DNLI4_ORYSJ/774-806                  .....m--HKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
E9IXA3_SOLIN/169-202                 ......TKHKITKNY.DEYYD..NFTVYADEE.SLKRSFGKIGK......
D3B9H0_POLPA/864-897                 ......TRDIFSKEI.DPYGD..SFTEDTDVQ.TLKDAFKQIE-r.....
Q4SED8_TETNG/740-772                 ......TREHFAKEY.DVYGD..SYFVDSDEG.QLREVFGRM--r.....
J3M165_ORYBR/362-395                 .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
F0ZI28_DICPU/898-931                 ......TKKKFLLES.DPFGD..SYFNETNFS.ELKDCFNQVDK......
E2R0G7_CANFA/750-783                 ......TKEHFAREY.DCYGD..SYFVDLDLN.QLKEVFSGIKN......
E3Q270_COLGM/823-854                 ..tval------QNT.DMYGD..SYARDISLD.ELRAIFKSM--pk....
A7E283_DANRE/754-787                 ......TREHFAKEY.DQYGD..SYYVDTSEQ.QLRDVIERIS-s.....
A0A024RE06_HUMAN/750-783             ......TKEHFAREY.DCYGD..SYFIDTDLN.QLKEVFSGIKN......
W5MR27_LEPOC/765-798                 ......TKQHFATEY.DCFGD..SYYADTDEK.ELKEVFSRISK......
F6SN56_XENTR/753-786                 ......TAEHFACEY.DCYGD..SYITDTSEY.QLREVFHRMSN......
E5S760_TRISP/467-493                 ......-KRHFKRNF.DQYGD..SYTDPVDSE.TLHD-------l.....
C5YFJ3_SORBI/694-727                 .....a-RHKFPEEI.DSYAD..YYYWDIEIA.DLKQIFSNIDK......
M7CF39_CHEMY/754-787                 ......TKQRFACEY.DCYGD..SYTADTEVT.QLKEVFSRINN......
M0WXP9_HORVD/141-174                 .....a-RHKFPEEI.DLYAD..FYYWDIDVS.DLKQIFINMDK......
W9Y2V3_9EURO/903-933                 .elyed-------NV.DEYGD..SFARDVSEE.ELKEIMAKM--g.....
G1Q2N1_MYOLU/750-783                 ......TKQHFAREY.DCYGD..SYFVDTDLN.QLKEVFSGIK-d.....
W5C1K1_WHEAT/628-661                 .....a-RHKFPEEI.DSYAD..FYYWDIDVS.DLKQIFINMDK......
I1GES4_AMPQE/778-811                 ......TASKFSEIY.DKYGD..SYIHDTSET.TLREIFDKMK-d.....
DNLI4_HUMAN/750-783                  ......TKEHFAREY.DCYGD..SYFIDTDLN.QLKEVFSGIKN......
#=GR DNLI4_HUMAN/750-783       SS    ......HHHHHHHHB.-TTS-..BSSS---HH.HHHHHHHCS--......
I1EAN9_AMPQE/118-151                 ......TASKFSEVY.DKYGD..SYIDDTSET.TLREIFDKMK-d.....
S4RIR1_PETMA/473-506                 ......TKQEYTKEF.DEHGD..SYFSPTDDA.QLREVFGRMA-e.....
W2ZHX1_PHYPR/799-827                 ......-RELLAKEY.DRYGD..HFTEHITPD.NLQRI------lr....
Q28EB8_XENTR/753-786                 ......TAEHFACEY.DCYGD..SYITDTSEY.QLREVFHRMSN......
H0ZKK3_TAEGU/749-782                 ......TKEHFAREY.DCYGD..SYTANTDVT.QLKEVFSRMK-d.....
DNLI4_CHICK/755-788                  ......TREHFAREY.DCYGD..SYTADTDVA.QLKEVFSRVK-d.....
W4W9D9_ATTCE/268-301                 ......TRRQITENY.DEYYD..SFVVDADEE.SLKRSFGKIAK......
W5KLF1_ASTMX/809-842                 ......TREHFAKEY.DRYGD..SYYINTDEQ.QLRDIFKRIDQ......
A0A026WQU9_CERBI/753-786             ......TRHRLAQNY.DEYYD..NFTVDADRE.SLQRSSDRIDN......
Q7QFQ8_ANOGA/742-766                 ......TRMRLAQQY.DRYGD..SYTRPTTPT.-----------sf....
G1MMZ0_AILME/755-788                 ......TKEHFAREY.DHYGD..SYFIDTDLN.QLKEVFSGIKN......
T1JBC6_STRMM/750-783                 ......TIDRLALDF.DEYGD..SYTEEIDEK.KLKSIFQQID-v.....
N1PYV5_MYCP1/819-847                 ....dn-------NV.DEYGD..SYTRDVTPQ.ELLELFKKM--ps....
E2A5G0_CAMFO/745-778                 ......TKHRLTENY.DEYYD..NFIVDADEE.TLRRSFDKIGK......
L9JAZ9_TUPCH/683-716                 ......TKQHFAHQY.DCYGD..SYFVDTDLN.QLKEVFSGIK-h.....
D2H2R3_AILME/750-783                 ......TKEHFAREY.DHYGD..SYFIDTDLN.QLKEVFSGIKN......
H0XJL8_OTOGA/754-787                 ......TKEHFAREY.DCYGD..SYFVDTDLN.QLKEVFSGIR-s.....
W1PY88_AMBTC/758-791                 .....s-KKKLKEEI.DAFSD..YYYWDLDVT.DLRELFNKIDK......
I1J1I5_BRADI/732-765                 .....a-RHKFLEEI.DSYAD..FYYWDIDVA.DLKQIFSNMN-t.....
L5LFH6_MYODS/860-893                 ......TKQHFAREY.DRYGD..SYFVDTDLN.QLKEVFSGIK-d.....
Q533U6_MUNMU/88-121                  ......TKQHFAQEY.DQYGD..SYFVDTDVH.QLKEVFSGIKN......
M0WXP5_HORVD/399-432                 .....a-RHKFPEEI.DLYAD..FYYWDIDVS.DLKQIFINMDK......
I3K1S4_ORENI/766-799                 ......TREHFAKEY.DNYGD..SYFVDTDEQ.QLREVFNRIS-s.....
U6MY78_9EIME/919-947                 .....q--QQLAQDY.DQYGD..SYYDSTTPE.ELRHC------lq....
K7F0E0_PELSI/754-787                 ......TKQHFACEY.DCYGD..SYTADTDLT.QIKEVFSRIN-e.....
F1Q9E8_DANRE/754-787                 ......TREHFAKEY.DQYGD..SYYVDTSEQ.QLRDVIERIS-s.....
B8ATU5_ORYSI/773-806                 .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
K1R0N9_CRAGI/755-788                 ......TQMALKKDY.DEFGD..SYMQDTTPD.QLKYTFQHMDN......
L5KU26_PTEAL/750-783                 ......TKQHFAREY.DCYGD..SYFIDTDLN.QLKEVFSGIKN......
G7PVQ1_MACFA/750-783                 ......TKEHFAREY.DCYGD..SYFVDTDLN.QLKEVFSGIKN......
#=GC SS_cons                         ......HHHHHHHHB.-TTS-..BSSS---HH.HHHHHHHCS--......
#=GC seq_cons                        ......T+p+FucEY.DpYGD..SYhhDschs.pL+-lFsthp.......
//
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