GenomeNet

Database: Pfam
Entry: DNA_ligase_IV
LinkDB: DNA_ligase_IV
Original site: DNA_ligase_IV 
#=GF ID   DNA_ligase_IV
#=GF AC   PF11411.6
#=GF DE   DNA ligase IV
#=GF AU   Pollington J
#=GF SE   pdb_1ik9
#=GF GA   21.20 21.20;
#=GF TC   21.20 21.40;
#=GF NC   21.10 21.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11702069
#=GF RT   Crystal structure of an Xrcc4-DNA ligase IV complex. 
#=GF RA   Sibanda BL, Critchlow SE, Begun J, Pei XY, Jackson SP, Blundell
#=GF RA   TL, Pellegrini L; 
#=GF RL   Nat Struct Biol. 2001;8:1015-1019.
#=GF DR   INTERPRO; IPR021536;
#=GF CC   DNA ligase IV along with Xrcc4 functions in DNA non-homologous
#=GF CC   end joining. This process is required to mend double-strand
#=GF CC   breaks. Upon ligase binding to an Xrcc4 dimer, the helical tails
#=GF CC   unwind leading to a flat interaction surface [1].
#=GF SQ   188
#=GS G1TA35_RABIT/750-783        AC G1TA35.1
#=GS G4V908_SCHMA/63-93          AC G4V908.1
#=GS A0A0D9ZQB8_9ORYZ/732-765    AC A0A0D9ZQB8.1
#=GS A0A0B2WXE2_9HYPO/833-863    AC A0A0B2WXE2.1
#=GS A0A0E0KUV9_ORYPU/726-759    AC A0A0E0KUV9.1
#=GS G3GTP0_CRIGR/750-783        AC G3GTP0.1
#=GS G6DJA3_DANPL/1164-1197      AC G6DJA3.1
#=GS A0A093YWY0_9PEZI/835-867    AC A0A093YWY0.1
#=GS U6GJ55_EIMAC/884-910        AC U6GJ55.1
#=GS Q23RI5_TETTS/880-907        AC Q23RI5.1
#=GS A0A0D9ZQC2_9ORYZ/720-753    AC A0A0D9ZQC2.1
#=GS I1GES5_AMPQE/778-811        AC I1GES5.1
#=GS M0WXP7_HORVD/289-322        AC M0WXP7.1
#=GS H3CYB9_TETNG/752-783        AC H3CYB9.1
#=GS V9FEY5_PHYPR/799-827        AC V9FEY5.1
#=GS I3NG11_ICTTR/750-783        AC I3NG11.1
#=GS W4YR11_STRPU/691-723        AC W4YR11.1
#=GS F6TM13_CALJA/750-783        AC F6TM13.1
#=GS H2NKF6_PONAB/750-783        AC H2NKF6.1
#=GS A0A091DXN0_FUKDA/816-849    AC A0A091DXN0.1
#=GS W3WI38_9PEZI/834-864        AC W3WI38.1
#=GS A0A0E0KUW0_ORYPU/686-719    AC A0A0E0KUW0.1
#=GS A0A067R3N3_ZOONE/740-772    AC A0A067R3N3.1
#=GS B2AWA2_PODAN/817-847        AC B2AWA2.1
#=GS M3Z4P4_MUSPF/750-783        AC M3Z4P4.1
#=GS D0MXT4_PHYIT/803-833        AC D0MXT4.1
#=GS F4X7Z3_ACREC/752-785        AC F4X7Z3.1
#=GS B3RS92_TRIAD/749-783        AC B3RS92.1
#=GS A0A094DC22_9PEZI/839-871    AC A0A094DC22.1
#=GS A0E0N5_PARTE/4-32           AC A0E0N5.1
#=GS U6KFF2_9EIME/16-42          AC U6KFF2.1
#=GS K3WBD5_PYTUL/805-838        AC K3WBD5.1
#=GS W6Q914_PENRO/821-853        AC W6Q914.1
#=GS M0WXP8_HORVD/627-660        AC M0WXP8.1
#=GS H2LGF6_ORYLA/758-791        AC H2LGF6.1
#=GS A0A0J8CRH1_BETVU/756-788    AC A0A0J8CRH1.1
#=GS F1P275_CHICK/755-788        AC F1P275.1
#=GS G3S2K5_GORGO/750-783        AC G3S2K5.1
#=GS A0A0L0N4T9_9HYPO/834-866    AC A0A0L0N4T9.1
#=GS W9VK48_9EURO/913-945        AC W9VK48.1
#=GS I1PPI3_ORYGL/709-742        AC I1PPI3.1
#=GS V4CSZ7_LOTGI/757-790        AC V4CSZ7.1
#=GS M3XAQ1_FELCA/750-783        AC M3XAQ1.1
#=GS A0A0D9ZQB6_9ORYZ/642-675    AC A0A0D9ZQB6.1
#=GS W9Y3F1_9EURO/854-886        AC W9Y3F1.1
#=GS G0QW01_ICHMG/777-803        AC G0QW01.1
#=GS A0A0D2X3G4_CAPO3/862-895    AC A0A0D2X3G4.1
#=GS A0A068RRY7_9FUNG/774-806    AC A0A068RRY7.1
#=GS J9JYG2_ACYPI/743-772        AC J9JYG2.2
#=GS W2S946_9EURO/834-866        AC W2S946.1
#=GS A0A0F8UVM7_9EURO/828-860    AC A0A0F8UVM7.1
#=GS A0A0C4DGV9_HUMAN/683-716    AC A0A0C4DGV9.1
#=GS A7SKL4_NEMVE/737-770        AC A7SKL4.1
#=GS F1MB07_BOVIN/750-783        AC F1MB07.2
#=GS A0A066Y0Q3_COLSU/834-866    AC A0A066Y0Q3.1
#=GS M4AL27_XIPMA/755-788        AC M4AL27.1
#=GS K7J781_NASVI/776-809        AC K7J781.1
#=GS A0A094AKN4_9PEZI/835-867    AC A0A094AKN4.1
#=GS T1G253_HELRO/764-796        AC T1G253.1
#=GS G2QBD6_MYCTT/860-892        AC G2QBD6.1
#=GS DNLI4_DICDI/924-957         AC Q54CR9.1
#=GS A0A0E0PDS1_ORYRU/633-666    AC A0A0E0PDS1.1
#=GS M2N1Y8_BAUCO/808-840        AC M2N1Y8.1
#=GS K9G0M2_PEND2/796-827        AC K9G0M2.1
#=GS F4PGQ7_DICFS/816-849        AC F4PGQ7.1
#=GS A0A0E0KUW1_ORYPU/711-744    AC A0A0E0KUW1.1
#=GS D4A0U6_RAT/750-783          AC D4A0U6.1
#=GS A0A096N3D0_PAPAN/750-783    AC A0A096N3D0.1
#=GS G3W6K3_SARHA/732-765        AC G3W6K3.1
#=GS G1NR93_MELGA/755-788        AC G1NR93.1
#=GS G1KPZ8_ANOCA/749-782        AC G1KPZ8.1
#=GS F6X700_HORSE/742-775        AC F6X700.1
#=GS H6BN77_EXODN/861-893        AC H6BN77.1
#=GS DNLI4_PONAB/750-783         AC Q5R6L3.1
#=GS R7YQF8_CONA1/836-866        AC R7YQF8.1
#=GS H2TKB5_TAKRU/752-785        AC H2TKB5.1
#=GS K3Y4S0_SETIT/710-743        AC K3Y4S0.1
#=GS A0A0D9MG81_9EURO/821-853    AC A0A0D9MG81.1
#=GS S3BUX2_OPHP1/891-919        AC S3BUX2.1
#=GS S9XMP9_9CETA/683-716        AC S9XMP9.1
#=GS A0A087X4Q7_POEFO/755-788    AC A0A087X4Q7.2
#=GS H0VQM4_CAVPO/750-783        AC H0VQM4.1
#=GS A0A0D9ZQC1_9ORYZ/597-630    AC A0A0D9ZQC1.1
#=GS A0A0D9ZQC0_9ORYZ/630-663    AC A0A0D9ZQC0.1
#=GS F6SA46_MONDO/750-783        AC F6SA46.1
#=GS A0A0D9W949_9ORYZ/747-780    AC A0A0D9W949.1
#=GS U3I1H5_ANAPL/721-754        AC U3I1H5.1
#=GS X6MLA4_RETFI/449-482        AC X6MLA4.1
#=GS A0A0D9ZQB7_9ORYZ/752-785    AC A0A0D9ZQB7.1
#=GS G1X6G5_ARTOA/796-823        AC G1X6G5.1
#=GS A0A093XUQ6_9PEZI/839-871    AC A0A093XUQ6.1
#=GS W2QEC0_PHYPN/799-827        AC W2QEC0.1
#=GS A0A086TGU3_ACRCH/838-867    AC A0A086TGU3.1
#=GS A0A0F8DG60_CERFI/743-776    AC A0A0F8DG60.1
#=GS L2G8K7_COLGN/835-863        AC L2G8K7.1
#=GS G3PM28_GASAC/754-787        AC G3PM28.1
#=GS U4UGE6_DENPD/704-728        AC U4UGE6.1
#=GS W5B7I6_WHEAT/746-779        AC W5B7I6.1
#=GS M3C742_SPHMS/711-743        AC M3C742.1
#=GS V5FLX0_BYSSN/829-861        AC V5FLX0.1
#=GS V8NTK3_OPHHA/753-786        AC V8NTK3.1
#=GS A0A0J7KRD7_LASNI/266-299    AC A0A0J7KRD7.1
#=GS H2R1R7_PANTR/750-783        AC H2R1R7.1
#=GS A0A075AYN0_9FUNG/294-326    AC A0A075AYN0.1
#=GS A0A0E0KUV8_ORYPU/723-756    AC A0A0E0KUV8.1
#=GS T0JS13_COLGC/835-863        AC T0JS13.1
#=GS G5B8M6_HETGA/750-783        AC G5B8M6.1
#=GS R8BCR9_TOGMI/833-865        AC R8BCR9.1
#=GS G0REV3_HYPJQ/800-827        AC G0REV3.1
#=GS A0A0D9W947_9ORYZ/772-805    AC A0A0D9W947.1
#=GS G1R8S8_NOMLE/750-783        AC G1R8S8.1
#=GS S8CUB9_9LAMI/745-777        AC S8CUB9.1
#=GS W5ASW8_WHEAT/390-423        AC W5ASW8.1
#=GS A0A0D9W951_9ORYZ/732-765    AC A0A0D9W951.1
#=GS K1RAZ9_CRAGI/457-492        AC K1RAZ9.1
#=GS E2BTB8_HARSA/750-778        AC E2BTB8.1
#=GS U3JNN2_FICAL/755-788        AC U3JNN2.1
#=GS F1RLP1_PIG/749-782          AC F1RLP1.2
#=GS A0A015JCI6_9GLOM/276-307    AC A0A015JCI6.1
#=GS U6LHJ7_9EIME/363-389        AC U6LHJ7.1
#=GS A0A0D9ZQB9_9ORYZ/602-635    AC A0A0D9ZQB9.1
#=GS DNLI4_MOUSE/750-783         AC Q8BTF7.2
#=GS A0A022PR34_ERYGU/747-780    AC A0A022PR34.1
#=GS U9UHK1_RHIID/755-786        AC U9UHK1.1
#=GS B7QI11_IXOSC/745-777        AC B7QI11.1
#=GS A0A0D3FZW9_9ORYZ/704-737    AC A0A0D3FZW9.1
#=GS A0A084QKS0_9HYPO/826-859    AC A0A084QKS0.1
#=GS H3A217_LATCH/753-786        AC H3A217.1
#=GS G3U8L5_LOXAF/752-785        AC G3U8L5.1
#=GS A0A088A608_APIME/726-759    AC A0A088A608.1
#=GS DNLI4_ORYSJ/774-806         AC Q7X7E9.2
#=GS E9IXA3_SOLIN/169-202        AC E9IXA3.1
#=GS A0A074VI16_9PEZI/805-831    AC A0A074VI16.1
#=GS D3B9H0_POLPA/864-897        AC D3B9H0.1
#=GS J3M165_ORYBR/362-395        AC J3M165.1
#=GS F0ZI28_DICPU/898-931        AC F0ZI28.1
#=GS E2R0G7_CANLF/750-783        AC E2R0G7.1
#=GS E3Q270_COLGM/823-854        AC E3Q270.1
#=GS A0A0L7L3G1_9NEOP/1274-1293  AC A0A0L7L3G1.1
#=GS A0A0E0PDS0_ORYRU/735-768    AC A0A0E0PDS0.1
#=GS A0A0M8PDM9_9EURO/870-902    AC A0A0M8PDM9.1
#=GS W5MR27_LEPOC/765-798        AC W5MR27.1
#=GS F6SN56_XENTR/753-786        AC F6SN56.1
#=GS E5S760_TRISP/467-493        AC E5S760.1
#=GS C5YFJ3_SORBI/694-727        AC C5YFJ3.1
#=GS M7CF39_CHEMY/754-787        AC M7CF39.1
#=GS A0A0E0PDS2_ORYRU/692-725    AC A0A0E0PDS2.1
#=GS M0WXP9_HORVD/141-174        AC M0WXP9.1
#=GS W9Y2V3_9EURO/903-933        AC W9Y2V3.1
#=GS G1Q2N1_MYOLU/750-783        AC G1Q2N1.1
#=GS W5C1K1_WHEAT/628-661        AC W5C1K1.1
#=GS I1GES4_AMPQE/778-811        AC I1GES4.1
#=GS A0A0D9SA95_CHLSB/750-783    AC A0A0D9SA95.1
#=GS A0A0F4Z9G2_9PEZI/859-890    AC A0A0F4Z9G2.1
#=GS DNLI4_HUMAN/750-783         AC P49917.2
#=GS DNLI4_HUMAN/750-783         DR PDB; 3II6 Y; 750-783;
#=GS DNLI4_HUMAN/750-783         DR PDB; 3II6 X; 750-783;
#=GS DNLI4_HUMAN/750-783         DR PDB; 2E2W A; 104-113;
#=GS DNLI4_HUMAN/750-783         DR PDB; 1IK9 C; 755-782;
#=GS I1EAN9_AMPQE/118-151        AC I1EAN9.1
#=GS A0A094BGB9_9PEZI/835-867    AC A0A094BGB9.1
#=GS A0A0A2L2M8_PENIT/821-853    AC A0A0A2L2M8.1
#=GS H0ZKK3_TAEGU/749-782        AC H0ZKK3.1
#=GS A0A0D9W946_9ORYZ/784-817    AC A0A0D9W946.1
#=GS A0A068RU19_9FUNG/777-809    AC A0A068RU19.1
#=GS DNLI4_CHICK/755-788         AC Q90YB1.2
#=GS W4W9D9_ATTCE/268-301        AC W4W9D9.1
#=GS W5KLF1_ASTMX/809-842        AC W5KLF1.1
#=GS Q7QFQ8_ANOGA/742-766        AC Q7QFQ8.4
#=GS G1MMZ0_AILME/755-788        AC G1MMZ0.1
#=GS T1JBC6_STRMM/750-783        AC T1JBC6.1
#=GS N1PYV5_DOTSN/819-847        AC N1PYV5.1
#=GS A0A0D3FZX0_9ORYZ/602-635    AC A0A0D3FZX0.1
#=GS A0A0D9W948_9ORYZ/748-781    AC A0A0D9W948.1
#=GS A0A0E0PDS3_ORYRU/672-705    AC A0A0E0PDS3.1
#=GS E2A5G0_CAMFO/745-778        AC E2A5G0.1
#=GS L9JAZ9_TUPCH/683-716        AC L9JAZ9.1
#=GS H0XJL8_OTOGA/754-787        AC H0XJL8.1
#=GS A0A0A2K821_PENEN/1244-1276  AC A0A0A2K821.1
#=GS A0A0D9W950_9ORYZ/762-795    AC A0A0D9W950.1
#=GS W1PY88_AMBTC/758-791        AC W1PY88.1
#=GS I1J1I5_BRADI/732-765        AC I1J1I5.1
#=GS L5LFH6_MYODS/860-893        AC L5LFH6.1
#=GS M0WXP5_HORVD/399-432        AC M0WXP5.1
#=GS I3K1S4_ORENI/766-799        AC I3K1S4.1
#=GS U6MY78_9EIME/919-947        AC U6MY78.1
#=GS A0A0N1H198_9EURO/868-900    AC A0A0N1H198.1
#=GS F1Q9E8_DANRE/754-787        AC F1Q9E8.1
#=GS B8ATU5_ORYSI/773-806        AC B8ATU5.1
#=GS K1R0N9_CRAGI/755-788        AC K1R0N9.1
#=GS L5KU26_PTEAL/750-783        AC L5KU26.1
#=GS G7PVQ1_MACFA/750-783        AC G7PVQ1.1
G1TA35_RABIT/750-783                   ......TKKHFALEY.DCYGD..SYFVDTDLN.QLKEVFSGIKN......
G4V908_SCHMA/63-93                     .....a--AKMAQEY.DKFGD..SYSEPITSD.ELK--------fnlndi
A0A0D9ZQB8_9ORYZ/732-765               .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
A0A0B2WXE2_9HYPO/833-863               ....ia-----AENT.DRHGD..SYARDVGVD.ELREILGRMAK......
A0A0E0KUV9_ORYPU/726-759               .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
G3GTP0_CRIGR/750-783                   ......TKQHFAREY.DCYGD..SYFVDTDLD.QLKEVFLGIKK......
G6DJA3_DANPL/1164-1197                 ......TKLKLSLDY.DPFGD..SYKDEIDEK.TLKKLLDKMD-s.....
A0A093YWY0_9PEZI/835-867               .....e--ERIQQNV.DRFGD..SYARDVGAE.ELKEICD----gmpk..
U6GJ55_EIMAC/884-910                   ......-KRQLQQNY.DIYGD..SYLEDTTPN.EL---------eha...
Q23RI5_TETTS/880-907                   ...kll--------Y.DQYGD..SYYKDVDED.ELLDILK----smk...
A0A0D9ZQC2_9ORYZ/720-753               .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
I1GES5_AMPQE/778-811                   ......TASKFSEIY.DKYGD..SYIHDTSET.TLREIFDKMK-d.....
M0WXP7_HORVD/289-322                   .....a-RHKFPEEI.DLYAD..FYYWDIDVS.DLKQIFINMDK......
H3CYB9_TETNG/752-783                   ......TREHFAKEY.DVYGD..SYFVDSDEG.QLREVFGR---s.....
V9FEY5_PHYPR/799-827                   ......-RELLAKEY.DRYGD..HFTEHITPD.NLQRI------lr....
I3NG11_ICTTR/750-783                   ......TKQHFAREY.DPYGD..SYFVDTDLN.LLKEVFSGIKN......
W4YR11_STRPU/691-723                   .....t--AQFALDY.DCHGD..SYTQDVNEE.KLREVFANVEK......
F6TM13_CALJA/750-783                   ......TKEHFAREY.DCYGD..SYFVDTDLN.QLKEVFSGIKN......
H2NKF6_PONAB/750-783                   ......TKEHFAREY.DCYGD..SYFVDTDLN.QLKEVFSGIKN......
A0A091DXN0_FUKDA/816-849               ......TKQHFSREY.DRYGD..SYFVDTDLN.QLKEVFSGIKN......
W3WI38_9PEZI/834-864                   .....k--EQAQENL.DDYGD..SYARDIDVA.ELKA-------llqdm.
A0A0E0KUW0_ORYPU/686-719               .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
A0A067R3N3_ZOONE/740-772               .....s--EQLSVEF.DKFGD..SYTQPLTEE.SLKYVLEQVEK......
B2AWA2_PODAN/817-847                   ...kla-----AENT.DQYGD..SYVRDVTPD.ELRDI------iddmr.
M3Z4P4_MUSPF/750-783                   ......TKEHFAREY.DCYGD..SYFVDTDLN.RLKEVFSGIKN......
D0MXT4_PHYIT/803-833                   ......-RQLLAKEY.DRYGD..HFTEHVTPD.DLRRI------lqel..
F4X7Z3_ACREC/752-785                   ......TRRQLTENY.DEYYD..SFVVDADEE.SLKRSFDKIAK......
B3RS92_TRIAD/749-783                   ......TAEVFAKEY.DKYGD..SYTKDIDNPvALKAIFDKINN......
A0A094DC22_9PEZI/839-871               .....e--ERIQKNV.DRFGD..SYARDVGAA.ELKEI------cddmpk
A0E0N5_PARTE/4-32                      ..vnkf--------Y.DKFGD..SYFELIDEF.ALKDICDNMK-......
U6KFF2_9EIME/16-42                     .....q--QQLQQAF.DMYGD..SFYKDTTPS.ELK--------ya....
K3WBD5_PYTUL/805-838                   ......TRALLAKEY.DQFGD..HFTEYVKPD.DLRLIFKEV--ar....
W6Q914_PENRO/821-853                   ...eee----VTANV.DKFMD..SYARDTTVD.ELKDVFKQME-q.....
M0WXP8_HORVD/627-660                   .....a-RHKFPEEI.DLYAD..FYYWDIDVS.DLKQIFINMDK......
H2LGF6_ORYLA/758-791                   ......TREHFAKEY.DPHGD..SYFLDTDGQ.QLREVFGRIG-d.....
A0A0J8CRH1_BETVU/756-788               ......-RKKLQEEI.DEFSD..SYFWDLNVA.ELKQIFCNVNK......
F1P275_CHICK/755-788                   ......TREHFAREY.DCYGD..SYTADTDVA.QLKEVFSRVK-d.....
G3S2K5_GORGO/750-783                   ......TKEHFAREY.DCYGD..SYFIDTDLN.QLKEVFSGIKN......
A0A0L0N4T9_9HYPO/834-866               ......TRAAAAQNT.DRYGD..SYARDVSMD.ELREI------madmp.
W9VK48_9EURO/913-945                   .....r--DRLGDNA.DEYGD..SYARDTSED.ELREIMDKMG-s.....
I1PPI3_ORYGL/709-742                   .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
V4CSZ7_LOTGI/757-790                   ......TQRKFDEDY.DVYGD..SYYTDTQED.QLKHVFDKMEK......
M3XAQ1_FELCA/750-783                   ......TKQHFAREY.DCYGD..SYFIDTDLN.QLKEVFSGIKN......
A0A0D9ZQB6_9ORYZ/642-675               .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
W9Y3F1_9EURO/854-886                   ......-RDRFADNV.DEYGD..SYARDTSVD.ELSKCMDRM--vd....
G0QW01_ICHMG/777-803                   ....al--------Y.DKYGD..PYFKEIDVE.ELRDILENM--s.....
A0A0D2X3G4_CAPO3/862-895               ......TRVEVAKFF.DAFGD..SYFEDTDEA.TLRTVFASMA-t.....
A0A068RRY7_9FUNG/774-806               ......TEEAFSASI.DKWGD..SYMQDATEQ.SLREVMERM--p.....
J9JYG2_ACYPI/743-772                   ...lmd------EKF.DQYGD..SYTELATVE.TLRRAMDRV--e.....
W2S946_9EURO/834-866                   ...dep----FEWNI.DKYGD..PYYRDTGVE.ELRDVFKKMT-s.....
A0A0F8UVM7_9EURO/828-860               .....q--EEISSNL.DRFND..SYTRDTTSE.ELRELLNQMSK......
A0A0C4DGV9_HUMAN/683-716               ......TKEHFAREY.DCYGD..SYFIDTDLN.QLKEVFSGIKN......
A7SKL4_NEMVE/737-770                   ......TTAKFREEY.DRHGD..SFTCDATAD.SLKTVFHNIAN......
F1MB07_BOVIN/750-783                   ......TKQHFAQEY.DQYGD..SYFVDTDLH.QLKEVFLGIKN......
A0A066Y0Q3_COLSU/834-866               .ktval------RNT.DRYGD..SYARDISLD.ELRAIFKSM--pk....
M4AL27_XIPMA/755-788                   ......TREHFAKEY.DSYGD..SYFVDTDEQ.QLREVFSRID-g.....
K7J781_NASVI/776-809                   ......TRRKLDDAY.DQYWD..NYTEDLDEE.TLKRVTKRIE-e.....
A0A094AKN4_9PEZI/835-867               .....e--ERIQKNV.DRFGD..SYARDVGAA.ELKEI------cddmpk
T1G253_HELRO/764-796                   ......TRQKFADDY.DGYGD..EYFCPTSPQ.QLKCLFDGI--q.....
G2QBD6_MYCTT/860-892                   ....mr---KLAEEStDQYGD..SYARDVGVD.ELRDILEQME-......
DNLI4_DICDI/924-957                    ......TKKRFLLDS.DQFGD..SYINETTEQ.SLKDSFNQIDK......
A0A0E0PDS1_ORYRU/633-666               .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
M2N1Y8_BAUCO/808-840                   ...agk----FDDAV.DEYGD..SYARDATPD.ELLTLFNRM--ps....
K9G0M2_PEND2/796-827                   .eevva-------NV.DQFMD..SYARDTTVE.ELKEVFKQME-q.....
F4PGQ7_DICFS/816-849                   ......TKQLLLQDI.DRFGD..SFTQDTTVD.ELLDSFNQITK......
A0A0E0KUW1_ORYPU/711-744               .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
D4A0U6_RAT/750-783                     ......TKQHFAREY.DCYGD..SYFVDADLD.QLKEVFLRIK-p.....
A0A096N3D0_PAPAN/750-783               ......TKEHFAREY.DCYGD..SYFVDTDLN.QLKEVFSGIKN......
G3W6K3_SARHA/732-765                   ......TKEHFAREY.DCYGD..SYFADTDLL.QLKEVFSRIKN......
G1NR93_MELGA/755-788                   ......TKEHFAREY.DCYGD..SYTADTDVA.QLKEVFSRVK-d.....
G1KPZ8_ANOCA/749-782                   ......TKQHFAREY.DCYGD..SYTADVGVA.QLKEVFSRMN-d.....
F6X700_HORSE/742-775                   ......TKEHFAREY.DCYGD..SYFVDTDVN.HLKEVFSGIKN......
H6BN77_EXODN/861-893                   ......-KDRYADNV.DQYGD..SFARDTSVD.ELSRCMDQMG-d.....
DNLI4_PONAB/750-783                    ......TKEHFAREY.DCYGD..SYFVDTDLN.QLKEVFSGIKN......
R7YQF8_CONA1/836-866                   ...qie------ANV.DEYGD..SFAQDVTVN.ELRRIFKGMS-s.....
H2TKB5_TAKRU/752-785                   ......TREHFAKEY.DAYGD..SYFVDTDEQ.QLREVFGRIR-s.....
K3Y4S0_SETIT/710-743                   .....a-RHKFPEEI.DSYAD..YYYWDIDIA.DLKQIFSNIDK......
A0A0D9MG81_9EURO/821-853               ....ee---EVAANV.DKFMD..SYARDTTVD.ELKDIFKQME-q.....
S3BUX2_OPHP1/891-919                   ....eh-------NT.DEYGD..SFARDVSVA.ELKEIFSKMD-t.....
S9XMP9_9CETA/683-716                   ......TREHFAREY.DCYGD..SYFVDTDLN.QLKEVFSGIK-d.....
A0A087X4Q7_POEFO/755-788               ......TREHFAKEY.DSYGD..SYFVDTDEQ.QLREVFSRID-g.....
H0VQM4_CAVPO/750-783                   ......TKQYFAREY.DCYGD..SYFVNTDLT.QLKEVFSGIKN......
A0A0D9ZQC1_9ORYZ/597-630               .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
A0A0D9ZQC0_9ORYZ/630-663               .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
F6SA46_MONDO/750-783                   ......TKEHFACEY.DCYGD..SYFADTDVV.QLKEVFSRIKN......
A0A0D9W949_9ORYZ/747-780               .....a-RHKFPEEI.DSYAD..YFYCDIDIS.DLKQIFSNMDK......
U3I1H5_ANAPL/721-754                   ......TKEHFAREY.DCYGD..SYTADTDVA.QLKEVFSRMK-d.....
X6MLA4_RETFI/449-482                   ......TKKNLQKDY.DRFGD..HYLQYATVD.TLNSIFTKID-l.....
A0A0D9ZQB7_9ORYZ/752-785               .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
G1X6G5_ARTOA/796-823                   .....s-KDKFEETI.DPYGD..SYYRDTTAE.DL---------skl...
A0A093XUQ6_9PEZI/839-871               .....e--ERIQKNV.DRFGD..SYARDVGAA.ELKEI------cddmpk
W2QEC0_PHYPN/799-827                   ......-RELLAKEY.DRYGD..HFTEHITPD.NLQRI------lr....
A0A086TGU3_ACRCH/838-867               ....ae------ENS.DPYGD..SYARDVSVE.ELREI------ladmpk
A0A0F8DG60_CERFI/743-776               ......TQKQVSETI.DIFGD..SFARDISIE.ELKDLFASM--pk....
L2G8K7_COLGN/835-863                   ....iq-------NT.DMYGD..SYARDISVD.ELRQVFKEV--pk....
G3PM28_GASAC/754-787                   ......TREHFAKEY.DSYGD..SYVADTDEQ.QLREVFGRMS-g.....
U4UGE6_DENPD/704-728                   clsdat---------.DRYGD..SYTQEATME.TLKHS------......
W5B7I6_WHEAT/746-779                   .....a-RHKFPEEI.DSYAD..FYYWDIDVS.DLKQIFINMDK......
M3C742_SPHMS/711-743                   ....eg---KFDDNV.DEFGD..SYARDVTAQ.DLLALFKEM--pt....
V5FLX0_BYSSN/829-861                   ......-KEVISQNV.DPFGD..SYARDTSVE.ELREIFNRMK-a.....
V8NTK3_OPHHA/753-786                   ......TKQHFACEY.DTYGD..SFTADTDPV.ELKAVFSRIN-t.....
A0A0J7KRD7_LASNI/266-299               ......TQHRLAENY.DEYYD..NFIVDADEE.TLKRSFDKIAK......
H2R1R7_PANTR/750-783                   ......TKEHFAREY.DCYGD..SYFIDTDLN.QLKEVFSGIKN......
A0A075AYN0_9FUNG/294-326               ......TLQSFRNLV.DCYGD..SYTEPVTVE.EFKELISKID-......
A0A0E0KUV8_ORYPU/723-756               .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
T0JS13_COLGC/835-863                   ....iq-------NT.DMYGD..SYARDIGVD.ELRQVFKEV--pk....
G5B8M6_HETGA/750-783                   ......TRQHFAREY.DRYGD..SYFVDTDLN.QLKEVFSGIKN......
R8BCR9_TOGMI/833-865                   akiaen-------NT.DQYGD..SYARDAEVE.ELREILANM--pk....
G0REV3_HYPJQ/800-827                   ..aeva-----AQNT.DRYGD..SYARDVDVE.ELRE-------lm....
A0A0D9W947_9ORYZ/772-805               .....a-RHKFPEEI.DSYAD..YFYCDIDIS.DLKQIFSNMDK......
G1R8S8_NOMLE/750-783                   ......TKEHFAREY.DCYGD..SYFVNTDLN.ELKEVFSGIKN......
S8CUB9_9LAMI/745-777                   ......-RKKFEGEI.DEFSD..SFYSDINAT.ELKQILGNID-e.....
W5ASW8_WHEAT/390-423                   .....a-RHKFPEEI.DSYAD..FYYWDIDVS.DLKQIFINMDK......
A0A0D9W951_9ORYZ/732-765               .....a-RHKFPEEI.DSYAD..YFYCDIDIS.DLKQIFSNMDK......
K1RAZ9_CRAGI/457-492                   ......TQMALKKDY.DKFGDtcSYMQDTTPD.QLKYTFQHMDN......
E2BTB8_HARSA/750-778                   ....sm-------EY.DIYYD..YYYIDATAS.TLQHSFARID-e.....
U3JNN2_FICAL/755-788                   ......TKEHFAREY.DCYGD..SYTANTDVA.QLREVFSRMK-d.....
F1RLP1_PIG/749-782                     ......TKQHFARQY.DCHGD..SYFVDTDVN.QLKEVFSGIK-t.....
A0A015JCI6_9GLOM/276-307               ......TKQEFLTRM.DEWGD..SYTDEVTIE.DLQETFD----lm....
U6LHJ7_9EIME/363-389                   .....q--QQLQQNF.DVYGD..SYYEDTSPN.ELRH-------a.....
A0A0D9ZQB9_9ORYZ/602-635               .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
DNLI4_MOUSE/750-783                    ......TKQHFAREY.DCYGD..SYFVDTDLD.QLKEVFLGIK-p.....
A0A022PR34_ERYGU/747-780               .....s-KKKLEEEI.DEFSD..SYYMDLNVA.DLKQILSNVDK......
U9UHK1_RHIID/755-786                   ......TKQEFLTRM.DEWGD..SYTDEVTIE.DLQETFD----lm....
B7QI11_IXOSC/745-777                   ......TERRLKAAF.DEWGD..SYTVPVTAE.SLRDLFEAI--p.....
A0A0D3FZW9_9ORYZ/704-737               .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
A0A084QKS0_9HYPO/826-859               ......TKEVVAQNT.DQYGD..SYARDVSID.ELREI------iagmpk
H3A217_LATCH/753-786                   ......TEQHFACEY.DRYGD..SFYADTAEH.QLKEVFLRISK......
G3U8L5_LOXAF/752-785                   ......TKQHFALEY.DCYGD..SYFVDTDLN.QLREVFSVIK-h.....
A0A088A608_APIME/726-759               ......TRQRLAQYY.DDYYD..HYTIDANEE.TLLRSFKKLEK......
DNLI4_ORYSJ/774-806                    .....m--HKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
E9IXA3_SOLIN/169-202                   ......TKHKITKNY.DEYYD..NFTVYADEE.SLKRSFGKIGK......
A0A074VI16_9PEZI/805-831               .....e--DSFKENI.DEYGD..SFARDVDIE.EL---------ekl...
D3B9H0_POLPA/864-897                   ......TRDIFSKEI.DPYGD..SFTEDTDVQ.TLKDAFKQIE-r.....
J3M165_ORYBR/362-395                   .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
F0ZI28_DICPU/898-931                   ......TKKKFLLES.DPFGD..SYFNETNFS.ELKDCFNQVDK......
E2R0G7_CANLF/750-783                   ......TKEHFAREY.DCYGD..SYFVDLDLN.QLKEVFSGIKN......
E3Q270_COLGM/823-854                   ..tval------QNT.DMYGD..SYARDISLD.ELRAIFKSM--pk....
A0A0L7L3G1_9NEOP/1274-1293             ......TRLHFAREY.DAFGD..SYTEE----.-----------e.....
A0A0E0PDS0_ORYRU/735-768               .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
A0A0M8PDM9_9EURO/870-902               ...eee----VTANV.DKFMD..SYARDTTVD.ELKDIFKQME-q.....
W5MR27_LEPOC/765-798                   ......TKQHFATEY.DCFGD..SYYADTDEK.ELKEVFSRISK......
F6SN56_XENTR/753-786                   ......TAEHFACEY.DCYGD..SYITDTSEY.QLREVFHRMSN......
E5S760_TRISP/467-493                   ......-KRHFKRNF.DQYGD..SYTDPVDSE.TLHD-------l.....
C5YFJ3_SORBI/694-727                   .....a-RHKFPEEI.DSYAD..YYYWDIEIA.DLKQIFSNIDK......
M7CF39_CHEMY/754-787                   ......TKQRFACEY.DCYGD..SYTADTEVT.QLKEVFSRINN......
A0A0E0PDS2_ORYRU/692-725               .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
M0WXP9_HORVD/141-174                   .....a-RHKFPEEI.DLYAD..FYYWDIDVS.DLKQIFINMDK......
W9Y2V3_9EURO/903-933                   .elyed-------NV.DEYGD..SFARDVSEE.ELKEIMAKM--g.....
G1Q2N1_MYOLU/750-783                   ......TKQHFAREY.DCYGD..SYFVDTDLN.QLKEVFSGIK-d.....
W5C1K1_WHEAT/628-661                   .....a-RHKFPEEI.DSYAD..FYYWDIDVS.DLKQIFINMDK......
I1GES4_AMPQE/778-811                   ......TASKFSEIY.DKYGD..SYIHDTSET.TLREIFDKMK-d.....
A0A0D9SA95_CHLSB/750-783               ......TKEHFAREY.DCYGD..SYFVDTDLN.QLKEVFSGIKN......
A0A0F4Z9G2_9PEZI/859-890               marvpe-------TI.DRYGD..SFARDITLQ.ELRDV------lagmt.
DNLI4_HUMAN/750-783                    ......TKEHFAREY.DCYGD..SYFIDTDLN.QLKEVFSGIKN......
#=GR DNLI4_HUMAN/750-783         SS    ......HHHHHHHHB.-TTS-..BSSS---HH.HHHHHHHCS-X......
I1EAN9_AMPQE/118-151                   ......TASKFSEVY.DKYGD..SYIDDTSET.TLREIFDKMK-d.....
A0A094BGB9_9PEZI/835-867               .....e--ERIQQNV.DKFGD..SYARDIGAE.ELKEICD----gmpk..
A0A0A2L2M8_PENIT/821-853               eeevaa-------SV.DKFMD..SYARDTTSA.ELKDIFKQME-q.....
H0ZKK3_TAEGU/749-782                   ......TKEHFAREY.DCYGD..SYTANTDVT.QLKEVFSRMK-d.....
A0A0D9W946_9ORYZ/784-817               .....a-RHKFPEEI.DSYAD..YFYCDIDIS.DLKQIFSNMDK......
A0A068RU19_9FUNG/777-809               ......TEEAFSASI.DKWGD..SYMQDATEQ.SLREVMERM--p.....
DNLI4_CHICK/755-788                    ......TREHFAREY.DCYGD..SYTADTDVA.QLKEVFSRVK-d.....
W4W9D9_ATTCE/268-301                   ......TRRQITENY.DEYYD..SFVVDADEE.SLKRSFGKIAK......
W5KLF1_ASTMX/809-842                   ......TREHFAKEY.DRYGD..SYYINTDEQ.QLRDIFKRIDQ......
Q7QFQ8_ANOGA/742-766                   ......TRMRLAQQY.DRYGD..SYTRPTTPT.-----------sf....
G1MMZ0_AILME/755-788                   ......TKEHFAREY.DHYGD..SYFIDTDLN.QLKEVFSGIKN......
T1JBC6_STRMM/750-783                   ......TIDRLALDF.DEYGD..SYTEEIDEK.KLKSIFQQID-v.....
N1PYV5_DOTSN/819-847                   ....dn-------NV.DEYGD..SYTRDVTPQ.ELLELFKKM--ps....
A0A0D3FZX0_9ORYZ/602-635               .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
A0A0D9W948_9ORYZ/748-781               .....a-RHKFPEEI.DSYAD..YFYCDIDIS.DLKQIFSNMDK......
A0A0E0PDS3_ORYRU/672-705               .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
E2A5G0_CAMFO/745-778                   ......TKHRLTENY.DEYYD..NFIVDADEE.TLRRSFDKIGK......
L9JAZ9_TUPCH/683-716                   ......TKQHFAHQY.DCYGD..SYFVDTDLN.QLKEVFSGIK-h.....
H0XJL8_OTOGA/754-787                   ......TKEHFAREY.DCYGD..SYFVDTDLN.QLKEVFSGIR-s.....
A0A0A2K821_PENEN/1244-1276             ....ee---EVAANV.DKFMD..SYARDTTVE.ELKDIFKQMEK......
A0A0D9W950_9ORYZ/762-795               .....a-RHKFPEEI.DSYAD..YFYCDIDIS.DLKQIFSNMDK......
W1PY88_AMBTC/758-791                   .....s-KKKLKEEI.DAFSD..YYYWDLDVT.DLRELFNKIDK......
I1J1I5_BRADI/732-765                   .....a-RHKFLEEI.DSYAD..FYYWDIDVA.DLKQIFSNMN-t.....
L5LFH6_MYODS/860-893                   ......TKQHFAREY.DRYGD..SYFVDTDLN.QLKEVFSGIK-d.....
M0WXP5_HORVD/399-432                   .....a-RHKFPEEI.DLYAD..FYYWDIDVS.DLKQIFINMDK......
I3K1S4_ORENI/766-799                   ......TREHFAKEY.DNYGD..SYFVDTDEQ.QLREVFNRIS-s.....
U6MY78_9EIME/919-947                   .....q--QQLAQDY.DQYGD..SYYDSTTPE.ELRHC------lq....
A0A0N1H198_9EURO/868-900               ....kg---TFDENV.DKYGD..AFYRETTVE.ELEQLFNKMD-d.....
F1Q9E8_DANRE/754-787                   ......TREHFAKEY.DQYGD..SYYVDTSEQ.QLRDVIERIS-s.....
B8ATU5_ORYSI/773-806                   .....a-RHKFPEEI.DSYAD..YFYWDIDIS.DLKQIFSNMD-r.....
K1R0N9_CRAGI/755-788                   ......TQMALKKDY.DEFGD..SYMQDTTPD.QLKYTFQHMDN......
L5KU26_PTEAL/750-783                   ......TKQHFAREY.DCYGD..SYFIDTDLN.QLKEVFSGIKN......
G7PVQ1_MACFA/750-783                   ......TKEHFAREY.DCYGD..SYFVDTDLN.QLKEVFSGIKN......
#=GC SS_cons                           ......HHHHHHHHB.-TTS-..BSSS---HH.HHHHHHHCS-X......
#=GC seq_cons                          .......+c+Fsc-h.DpYGD..SYhhDssls.pLKclFsphc.......
//
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