GenomeNet

Database: Pfam
Entry: DUF128
LinkDB: DUF128
Original site: DUF128 
#=GF ID   DUF128
#=GF AC   PF01995.13
#=GF DE   Domain of unknown function DUF128
#=GF AU   Enright A, Ouzounis C, Bateman A
#=GF SE   Enright A
#=GF GA   25.00 25.00;
#=GF TC   70.30 30.10;
#=GF NC   22.10 20.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR002846;
#=GF CC   This archaebacterial protein family has no known function. The
#=GF CC   domain is found duplicated in Swiss:O27611. Many of these are
#=GF CC   attached to an N-terminal winged helix domain suggesting these
#=GF CC   are transcriptional regulators and that this domain has a ligand
#=GF CC   binding function.
#=GF SQ   96
#=GS D5E8G5_METMS/85-320      AC D5E8G5.1
#=GS F0T764_METLA/84-314      AC F0T764.1
#=GS J1L4I4_9EURY/16-255      AC J1L4I4.1
#=GS Q2FSW2_METHJ/5-244       AC Q2FSW2.1
#=GS R9SIY3_9EURY/83-313      AC R9SIY3.1
#=GS O28056_ARCFU/83-321      AC O28056.1
#=GS R9SIY3_9EURY/334-563     AC R9SIY3.1
#=GS Q3Z7W5_DEHM1/100-339     AC Q3Z7W5.1
#=GS A6UTI8_META3/327-540     AC A6UTI8.1
#=GS D5VS72_METIM/316-532     AC D5VS72.1
#=GS Q2LQG6_SYNAS/84-323      AC Q2LQG6.1
#=GS L0KT34_METHD/85-324      AC L0KT34.1
#=GS Q2NHI2_METST/78-304      AC Q2NHI2.1
#=GS B5YGF1_THEYD/80-316      AC B5YGF1.1
#=GS E1QIV0_DESB2/84-323      AC E1QIV0.1
#=GS E3GY38_METFV/326-552     AC E3GY38.1
#=GS L0L1G5_METHD/7-246       AC L0L1G5.1
#=GS NRPR_METMP/316-532       AC Q6LZL7.1
#=GS D3E025_METRM/83-313      AC D3E025.1
#=GS D1YVU6_METPS/85-324      AC D1YVU6.1
#=GS NRPR1_METMA/85-322       AC Q8PXY1.1
#=GS E3GY38_METFV/84-307      AC E3GY38.1
#=GS F7XQB9_METZD/8-247       AC F7XQB9.1
#=GS Q46DJ8_METBF/85-322      AC Q46DJ8.1
#=GS D7DT16_METV3/364-580     AC D7DT16.1
#=GS B8GHD6_METPE/5-244       AC B8GHD6.1
#=GS D3SUV6_NATMM/83-193      AC D3SUV6.1
#=GS F0T764_METLA/333-563     AC F0T764.1
#=GS Q8THV7_METAC/119-357     AC Q8THV7.1
#=GS N0BJI1_9EURY/81-319      AC N0BJI1.1
#=GS Q46BP9_METBF/8-247       AC Q46BP9.1
#=GS U6E9K2_9EURY/334-563     AC U6E9K2.1
#=GS D1YUP9_METPS/8-247       AC D1YUP9.1
#=GS A6UTI8_META3/83-310      AC A6UTI8.1
#=GS K4MBG7_9EURY/85-324      AC K4MBG7.1
#=GS B8GJM0_METPE/83-313      AC B8GJM0.1
#=GS NRPR_METJA/86-305        AC Q57623.1
#=GS NRPR_METJA/86-305        DR PDB; 3NEK B; 322-538;
#=GS NRPR_METJA/86-305        DR PDB; 3NEK A; 322-538;
#=GS A0B6Y5_METTP/84-308      AC A0B6Y5.1
#=GS NRPR_METJA/322-538       AC Q57623.1
#=GS NRPR_METJA/322-538       DR PDB; 3NEK B; 322-538;
#=GS NRPR_METJA/322-538       DR PDB; 3NEK A; 322-538;
#=GS H1YYZ9_9EURY/85-316      AC H1YYZ9.1
#=GS K4MEK7_9EURY/7-246       AC K4MEK7.1
#=GS D7EBR2_METEZ/12-251      AC D7EBR2.1
#=GS L0HBK6_METFS/5-244       AC L0HBK6.1
#=GS Q8TYG2_METKA/85-323      AC Q8TYG2.1
#=GS D7E9U3_METEZ/85-323      AC D7E9U3.1
#=GS Q12VH9_METBU/85-323      AC Q12VH9.1
#=GS F6D855_METPW/84-314      AC F6D855.1
#=GS D8K457_DEHLB/90-329      AC D8K457.1
#=GS Q8TSH4_METAC/8-247       AC Q8TSH4.1
#=GS A7I5N3_METB6/83-314      AC A7I5N3.1
#=GS E1RE52_METP4/108-338     AC E1RE52.1
#=GS NRPR_METMP/81-299        AC Q6LZL7.1
#=GS H1YZ00_9EURY/6-245       AC H1YZ00.1
#=GS F7XPA1_METZD/85-323      AC F7XPA1.1
#=GS Q2NHI2_METST/324-552     AC Q2NHI2.1
#=GS I4BXA1_ANAMD/91-331      AC I4BXA1.1
#=GS G7WQV7_METH6/7-236       AC G7WQV7.1
#=GS F6BCA0_METIK/84-303      AC F6BCA0.1
#=GS F4BZP9_METCG/89-328      AC F4BZP9.1
#=GS G2MN03_9ARCH/87-270      AC G2MN03.1
#=GS H3ZNZ7_THELN/85-325      AC H3ZNZ7.1
#=GS A7IAT0_METB6/5-244       AC A7IAT0.1
#=GS E1RE54_METP4/5-243       AC E1RE54.1
#=GS A0B970_METTP/33-262      AC A0B970.1
#=GS D3SUV1_NATMM/226-362     AC D3SUV1.1
#=GS D5VS72_METIM/82-299      AC D5VS72.1
#=GS NRPR2_METMA/8-247        AC Q8PVJ4.1
#=GS Q0W3T7_METAR/85-324      AC Q0W3T7.1
#=GS D3S1I8_FERPA/83-323      AC D3S1I8.1
#=GS D5EGZ4_AMICL/86-326      AC D5EGZ4.1
#=GS A5UN44_METS3/83-311      AC A5UN44.1
#=GS Q0W777_METAR/8-247       AC Q0W777.1
#=GS D3E025_METRM/333-560     AC D3E025.1
#=GS F6D855_METPW/333-563     AC F6D855.1
#=GS O27611_METTH/332-560     AC O27611.1
#=GS B8E0N2_DICTD/84-325      AC B8E0N2.1
#=GS J1L096_9EURY/85-317      AC J1L096.1
#=GS G7WN74_METH6/89-328      AC G7WN74.1
#=GS L0HK37_METFS/83-314      AC L0HK37.1
#=GS D7DT16_METV3/81-310      AC D7DT16.1
#=GS A0A0A7GEH1_9EURY/80-314  AC A0A0A7GEH1.1
#=GS Q2FTS7_METHJ/83-315      AC Q2FTS7.1
#=GS F8F2H0_TRECH/85-324      AC F8F2H0.1
#=GS F4BX01_METCG/4-233       AC F4BX01.1
#=GS F6BCA0_METIK/320-536     AC F6BCA0.1
#=GS A5UN44_METS3/331-558     AC A5UN44.1
#=GS D5E812_METMS/8-247       AC D5E812.1
#=GS Q12VW5_METBU/8-247       AC Q12VW5.1
#=GS U6E9K2_9EURY/84-315      AC U6E9K2.1
#=GS A3CSY8_METMJ/86-317      AC A3CSY8.1
#=GS D3SUV1_NATMM/83-191      AC D3SUV1.1
#=GS D3SUV6_NATMM/199-332     AC D3SUV6.1
#=GS N0BK59_9EURY/87-323      AC N0BK59.1
#=GS O27611_METTH/88-313      AC O27611.1
#=GS D3RXS6_FERPA/85-322      AC D3RXS6.1
#=GS A3CSS1_METMJ/5-244       AC A3CSS1.1
D5E8G5_METMS/85-320                 ........LDFVITRIEDLIYRTDYDPVKKQGNVIVNVSYVD.......KDDFEKTAGLMRGAV--..DYSISPRVGVFEEDSE....DIFVPAGKVGIATVCSITFDGILLRHGIPVKPNFGGILSVE..NN.EPVVFKDLISYRGTSIDPIKIFLMRQST.....SVTGLLQ.SGSGTILANMRSIPQSAVGDASLLFQQLHESDIGGLLAMDN..ESGNV.LGAPVDV.GLSGIVVSAGV..NALAVVEEYGIDVTTRPVSTIMDYGTMK-t.................................................
F0T764_METLA/84-314                 ........VDFIFSKFEDMIHQTTLNPSDGTGKVIVNTSSFK.......--YEKDIIDLLKSVFER..GVAVSNYVKFHNTPVE....-----GEELKFDTVCGTTIDGMLLGKGIPVIPKYGGIVKVN..DY.VPTRFTELISYKKTSMTPLEAFTDKNMT.....SVLKVIE.NGNGTIPANFRLIPKSARASAASLFKDLEKIGIHGLLKMGK..EGESV.LGIPVDD.NMVGIAVTGGI..SPLCAAKEAGYDVNIKLAENNVEFKGME-n.................................................
J1L4I4_9EURY/16-255                 ........LKFLNHLIEEEAMQVTYDPAENEGKVIYNLSLVD.......ADDLDAVIAIMKETYRA..GISPSGLVQIFQTGEKa..gGYAVPKGKAGICTICSITLDGVMIRRGAPLHPIGGGVVQIE..NG.TPRRFTDMVLYDATTIDPLELLVSQEIT.....NVSGVIA.TGRGNVLANLRECHMEAESTVAAVIEDLERSMIAGVLEIGP..PNAPI.LGFTCSP.QYFGIAILGGT..NVMAAVKEGGYHVEINSLKGLIDVSSLE-p.................................................
Q2FSW2_METHJ/5-244                  .......l-RFVSHQIEDFAMQVTFNPVEGTGTVVYNLSLVR.......VEDLEQTISVFRATCEA..GVSPSSLIRILYAGEEl..dGFVIPQNFCGILTLCSTTLDGLLLQRGIPSNPIGGGVIEVA..EN.IPKRFTHLIKYEYTTIDPLQVLVSQEIT.....SVHQVMK.HGNGSILGNIRECHMEAEDDVEEVLDELTEGYFTGILDLGL..PNTPC.LGVAVDP.QYMGLAALGGT..NWMAALREEGISVTMQAMKGLCDISTME-f.................................................
R9SIY3_9EURY/83-313                 ........IDFTYSKFENYIYQTTFNPYTKTGNVIVNKSNVL.......---DKEALDIIKKAFET..GIAVSPRIQINKEKIG....----GVEGYTVESICGTTIDGVFLKNGIATQPQYGGIIEVK..NY.EPRRFKELISYKKTSITPLDAFIAKNMT.....SVLNVID.NGNGTIPANFRIIPGKVGNRAKKLIEKLNQANINGIIAIGK..KGENI.LGVPVPE.DFIGIAIAGGI..TPFCVAKELDYDVNIKLGEELEDYANLK-p.................................................
O28056_ARCFU/83-321                 .......l-GEFSERIEYNVYLSNFDLYTLSGLVPTNFAFID.......KSLFERAMEIVEECISQ..PISISNRIFIAEEGESl..gGYTVPKNSFALGVISNTIYDVILKTAGVNTTPEYAGLMSVE..NM.EARGLTELISYFGTTLSPGLLLLKAGLT.....SVYSACK.TGRGEIIVAIRSFSRYAMDIARRELEIAESKGLRGVIKILH..PSDRI.FGLPAA-.NRARLVVSAGL..NMIAPLFENGIIPEVRVNEFFVDFRDFR-v.................................................
R9SIY3_9EURY/334-563                .......i-PFFLSKSWNLIEEVDYDMETGEGNIIADISYVN.......KEDLDDSLKVIKNTYKDcpE-YITPYYKIVEDNKN....-----HDRVGIATVCSLSIDGILIKNGIMCKPKYGGLLEVN..DK.--SSFIELISYNGSSIDPHKIFILKDLT.....AINKD-E.TGARRLLASIKEIPNIAQYQSNEILKELSKKDLS-VLKIGK..PREMV.YNAQVNN.YKFGVVAGSGL..NTIAAIREKGIDIDIKAMETSMPLNEMD-r.................................................
Q3Z7W5_DEHM1/100-339                ........VGFVIDKIERLAYLTDFNLDTLSGMVPVNISFFA.......KEQFKPALRAMAQAYKA..NLCVSELVCIAHEGDKi..aDISVPAGQVAFATVCSIVINGTLLKAGIPMDSRFGGTLQFH..QN.KPRRFTDMIYYTGSSLDPSEIFIASRMT.....SVSEVAR.RGEGKVLCNFREIPAASLPLAEKIIAKLRNAGINGVLVVGE..AGKSV.CEMPSGL.NKVGMIMMGGL..NPVAAAVENDIPAASQAMSGLIPYSSFK-n.................................................
A6UTI8_META3/327-540                ........ISSVLSKMNSMMHNVNYDIEMERGAVLVNTGYID.......KSYKQDVIEILKECTNK..KQIISDKIGIIDKDNK....--------IQINTLCSTTIDGIFLKYGIPVIPYYGGILELN..KN.---RFIDTISYDGTSLDPHEVFFNK---.....------V.DGKNTILSGIRKAPMSARENLINIMEKL---NWTGIIEIGK..PNNPI.YGIKVEK.GMFGFATIGGI..NPFVVIKNSGIPIEINALHDVMEYSDL--t.................................................
D5VS72_METIM/316-532                ........IKTALSKMINLMAHVNYDIYEKDGDVIVNIGYID.......KKYLDEALDILKEAYSK..GLGISDRFGYEVLKDK....--------VKIKTICAVTLDGIINNLGVPIIPKYGGILEVK..EE.-EMRFIDIIKYSGTSLDPHEIFFNK---.....------V.DCETTFLAGFREIHRICREELERIIELL---EWNGIKCIGE..PNNEL.AGVKVNK.DMCGVITIGGA..NPLSFLNENEISVEIKAMHEITKFSEL--is................................................
Q2LQG6_SYNAS/84-323                 ........VGFLSAKIDTMTYQMNFDLNTASGKVVINVTLVE.......PGIFARSIPLVKKVYEK..GYAMGHLLTFLGPGETl..gYVTVPEGTIGIGTVCSITLNGVLLKHAIPTTSRFGGLLELQ..NG.KPLRFAEIIMYDGTSIDPLEIFIRSGMT.....NYIDAVQ.TGNGRIGASFREFPAESREMVEHLDRKMKRIGLGGLLRIGM..PGQSL.LDIPVSE.GRVGAIIIGGL..NPVSIMEETGVRLYSRALAGLIDFRKL--fh................................................
L0KT34_METHD/85-324                 .......l-DLVITRIEELVYKTTYDLREKKGNVIVNVSIID.......KSDYEKAMDVLKYAINA..GISISPRIRIVDEDSEe..dDIFVPDGKFAIANVCSITYDGILLKNGIPSTPLYGGLMQME..AH.QPVSFVDIIGYSGTSIDPIKIFINRHST.....SVLDYIE.SGNGKLLANLRHIPGSAREKAHEVMELAKDSDINGYLQIGE..TSEDV.FNVPMER.GKAGIPVIVGS..NAISAIAEAGIPVKAYPVSTIMDYNIMKK..................................................
Q2NHI2_METST/78-304                 ........VDFTFSRFQEKMYNVSLDYKKATGSVIVNISSIN.......--DL-DSSKIITDVFKE..GLSVSKHYNIVEKDDK....--------TYIETVCGTTIDGVFQQQGIITKPLYGGLLKVE..DY.VPINFTEQIAYENTSITPLEAFTGHDNT.....SVIDVIN.NGTGVIPANFRIIPEVKKQHALAILDNLKTIGIGGVIHIGN..PGEAV.LGIPVPE.GMVGIAVVGGV..TPLCAAREEGYDLSIKLADGYAEYSNM--in................................................
B5YGF1_THEYD/80-316                 ........VGFIINKIETLSYLSDFDINAMKGRLILNITYIH.......KNKFRKALKAMENVFTS..PYVMSDRILVLEKDSE....NILVPEDHVCIGTVCSVTLNAILLKHGIPIISRFGGVLEIR..EG.ESYRFGALISYDGTSLDPLEIFIRGKMT.....DVLGTIK.NGFGRVLASFREVPIVCLDKVKEIYSIMQKRGFQGIMMFGE..PNQPL.LDIPVGM.DRVGIIVVGGL..NPIAAIEENNIQTYTTAISVLYDCREL--v.................................................
E1QIV0_DESB2/84-323                 ........VGFVAARADALTYGMNFRLRQGKGSVVVNISTFE.......TARAGHAIEVMRRVYQA..GLSMGQRLALAGAGARl..gRLVVQPGEMAVATICSISVNGVLLAEGIPTTNRFGGLLQMR..GG.KPQRFLQIINYDGTTLDPLEIFIKGQMT.....SVSQAAA.TGDGVVGASFREIPTQAAEAARRLGARMERAGLGGILMIGR..PGQPL.LEVPVSQ.GRVGMIVLGGL..NPMAAVEEVGVPTGNRAMGTLLPFEDLR-p.................................................
E3GY38_METFV/326-552                .....ivp---LLTKVWNLIGQVDLDIKKLDGKVIANLSTID.......KKYLNDALEIFQTIIDEkpEYSVFPSIKLKERDNK....--------VDIATVCSLTIDGVLINNGIMSVPRYGGLLEIK..NN.-KKRFVELIDYSGSSFDPHEIYISKNMT.....KIYR--S.SKTSTILASLREIPYLARNKALKVIKKLKKANFQ-IMKVGK..TNEIL.YNAKVER.YRVGIVTPGGL..NLIAALKENGIKVNIKSAELLMDINEF--s.................................................
L0L1G5_METHD/7-246                  ........IQFTSAKIEDLMFRTTFDPVTREGKVIVNLSITN.......KKDLEDVMGIFEMAINS..GLSVSPYIRVLHEGDNi..eGITVGPDQVGFLTVCSITIDGVLLKKGVLVNPRFGGLVEIK..NG.IPLRFTNVLTYHSTTIDPLEVLMSQEVT.....SVTEMLK.TGSGKILANLREAPLAARDDIDRILSDMMDAGITGILEVGE..PNTRI.LDVPVER.DHLGIVVIGGT..NPMAIVQEHGIGIKLNAMSNVVDIKELR-h.................................................
NRPR_METMP/316-532                  .......v-TPVLSKMLSKMQTINYDIEDKKGNVVVNTAKIP.......IEYKEEAINALKDSYEN..KLAISDRLKVECDDKF....--------LNAYTICSLTVDGVFLKNKIPVIPYYGGILEVK..AD.-KKRFIEAIDYEGTSLDPHEVFFNK---.....------A.DGKNYILAGIRKVPMSASEKLIELNEKL---GWNSIIEIGR..PNNDI.CGVRVEK.CMFGITTIGGT..NPFANIRKNNIPVEMKTLHKSIDYSELT-h.................................................
D3E025_METRM/83-313                 ........VDFTLSKFKERIYLTDFDYKKKEGNVIVNTSNIL.......---ENKAFDIIKEVFAA..GVCVSPLINAKKTEIN....----GKKGYVMKTICGTTIDGVFLKNGIPSIPQYGGLVDIE..DY.YPTKFSELISYRKTSITPLDAFIAKGMT.....SVLEVAE.HGTGTIPANFRIIPESGLEKAKEIFEKLEKAGIGGILEIGE..ISENI.LGIPVPE.GMVGISIIGGI..TPFCAAQEMNYKVDIKTGEEFINYNKLK-e.................................................
D1YVU6_METPS/85-324                 ........LGFVSTRIEEYEFKTTFDPATDTGEAVVNICYIN.......KSDLDRSIDTLKRVVEA..GYAISPRLKVVDEGQEi..lENDVPEGQVALATFCSITIDGVLLKRGIPVNLKYGGLIRVK..DH.NAERFTEVIDYHGTSINPMNVFVSRKMT.....SVLKVLE.TGSGYVLANIREIPVNARENARQIISQLESADIHGIFSGCE..NMRPL.LGVPIET.GKCGIASYSGI..NPFAALTEMGIKTRIIPLSAVMNVNELK-r.................................................
NRPR1_METMA/85-322                  .......f-GFVISRIEEMAFRTTYNPETDKGDVVVNISYFD.......KDDFETVIELISYTAHA..GYMISPRVRIFEEDSL....EMSLPPGKIGIATVCSVTFDGLLLKAGIPVEPAYGGILQIE..NK.KPARFLDLISYSGTSIDPIKIFMNRTPT.....SVLEVLE.KGEGKILANMRQINSSAYEMTGKILKKAEKVGLAGCITLGE..IDEYL.LGAPVET.GKFGAAVVGGI..NGICALEETGIEIETNPISTMLDYQTMK-e.................................................
E3GY38_METFV/84-307                 ........VDFIFSRFENMMYETTLNPKTGEGKVVVNISVIP.......----SEAFNMMKKIFHT..GLCVSPKVGLNKKNGK....--------YEVKTICGTTVDGMLLNEGIPVIPKFGGLVEVE..DF.RPIKFTELIEYKKTSMTPLEAFATKELT.....SVLDVVN.EGKGKIPANFRIIPKSAKEKAINLFKKLRKIGINGLLKIGE..--KKV.LGVPVDD.GMIGIAIVGGI..TPICAVHEAGYDIDIKVAEDLTEFKNLK-t.................................................
F7XQB9_METZD/8-247                  ........LQFTSSKIEDLMYRTTFDPKSGDGDLIVNLSLFR.......EEDLEDVLNIFKTTISS..GLAVSPYVKMLHCGDTi..aGYRIEEGMAGIATVCSITIDGILLKSGVLVKPHFGGLVQIR..DG.MPVRFTDVLRYASTTIDPLEVLMSQEVT.....SVTRMLR.TGSGKILANLRGAPMIAREKVESVLADMMDAGISGILEVGE..PNTRI.LDVSVER.DHFGIVVIGGT..NPMAVVQESGIYIRTNAMSTLIGIDEMR-p.................................................
Q46DJ8_METBF/85-322                 .......f-GFVISRIEEMAFRTTYNPKTNEGVVPVNISYFD.......KDDLETVIEVVSYTAHE..GYMISPRVRIIEEDEE....LLSLPPGKVGIATVCSVVFDGLLLKAGIPVEPAYGGIIQIE..NR.KPARFSDLISYSGTSIDPIQIFMSRKTT.....SVLDVLE.KGEGKILANMRQINCSAYERAREVLKTVEKVGLAGYYPLGE..VDETL.FGAPVET.GKFGIAIVGGI..NGICALEETGIKMKTNPVSTVMEYNTMT-e.................................................
D7DT16_METV3/364-580                ........VKPVLSKMISMMHEVKFDLNNESGRIIVNMAKID.......LKYEEKVLKLLKEIYKR..DLSTSNKLKVEIDVKN....------ECLNIYTVCSLTFDGILLENQIPVIPYYGGLLERP..EM.---RFIEAIAYEGTSLDPHEVFFDK---.....------A.DGKTTILAGLRKVPMYSKSKIEEIYETL---GWNSILEFGR..PNNDL.CGIRVET.EMLGYVSVGGT..NPFAYLNINDIPVKIETHYKIMDYSELE-d.................................................
B8GHD6_METPE/5-244                  ........LKFINHSIEDFAIQVTYNPTEGTGQVVYNLSVFR.......TCDVAPAVEIIRGACRS..GVCVSDLVKFIPEGESl..dGYKIPPGSTGICTVCSITLDGLLLKRGVPLNPIGGGVIEIV..DR.IPRRFTQIIRYEDTTIDPLQVLASQDIT.....SISRVIS.TGNGTILANIRECHMEAEPLVAELLDDLADSRFTGVLEVGM..PNSPL.LGVQISP.QYIGMVAVGGT..NPIAAVKEAGYPVITRAMKGLLDVSEME-e.................................................
D3SUV6_NATMM/83-193                 .......v-EQVRERLADLTSHVTYNPETDDGDVVVGTVTVP.......ATNRSDVESIIAAIDDS..PL--GPAATALESVER....---DGEEFLEIAAPSSVTIDGVLLNEGIDTDLETTGVVEYH..A-.----------------------------.....-------.-----------------------------------------..-----.-------.-----------..-----------------------------dpesvpy...........................................
F0T764_METLA/333-563                ........VKFLLSKTWNLIYQVDFDVETHAGNVITNVSYIR.......KQDLDDAMDIFEEVMKVgpKFCTSKYFATVPGNEK....------DKVGIATVCSLTIDGILTKHGVSTTPQYGGILETN..SK.QP-RFIELTAYNGSSLDPHEIYIAKNMT.....SVNEAI-.KGGGRVLASLREIPYVSRQDAVEVLEEVQDAGFS-ILKIGK..PSELV.YNAKVER.YHVGIVAPGGL..NPIAALKEHGMDVEPKAVETMMKVSDME-e.................................................
Q8THV7_METAC/119-357                .......f-GFVISRIEEMAFRTTYDPETDKGDVVVNISYFD.......KDDFETVVDLVSYTAHA..GYMISPRVRIFEEDSE...sEIHLPPGKIGIATVCSVTFDGLLLKAGIPVEPAYGGILQIE..NK.KPSRFLDLISYSGTSIDPIKIFMNRTPT.....SVLEVLE.KGDGKILANMRQINASAYDTAKGIMKKAEKVDLAGCITIGE..IDEFL.LGAPVET.GKFGVAVVGGI..NGICALEETGIEIETNPISMMLDYRTMS-e.................................................
N0BJI1_9EURY/81-319                 .......l-GEFSERVEYNVFMSNFSIDEFKGTIPTNIAILD.......KKHYEKAMTILNEVSQS..RFIVSDLITVIDESERa..gYLEIPKNKFAVGIVSNTIFDVILRKYGVVLTPEASGLLHVE..KK.VPQGFSELISYSGTTLSPGWLFVKSRLT.....SVFRAEK.KGYGDVIATIRSFNVHLIDVVKRRVSEIEEKGIRGIISISY..PLENH.IIQSIN-.FKANLIIYAGV..NYLAPLQEKGLNPEIHINEQLIEISEFKK..................................................
Q46BP9_METBF/8-247                  ........VQFTSSRIKDLMYRTTFDPKKMDGDIILNLSLID.......KKDLDDVLGIFKMVISS..GLSVTPYVKIVSEGESi..gDLTVEKGKVGVGTVCSITIDGVLLKAGIPVNPKLGGVVQIR..NG.VPVRFTDVLTYVSTTVDPLEILMSQGIT.....SVSEMLR.TGSGKVLANLREAPMVARDEIESCLSDLLDAGFSGILEVGE..PNTRV.LDVPIER.DHLGIVVIGGT..NPMAVVQEYGIAIDTSAMSRLISFKEMS-r.................................................
U6E9K2_9EURY/334-563                ........VKFLLSKAWNLINEVDFDPETQQGKVIVNISYLK.......EENVEEGLKVFDEVMASrpEYCTSKYFQIVPGP--....-----HGKKGLATVCSLTIDGILTKKGIASTPQYGGILETK..GK.SP-RFIELTAYSGSSLDPHEIYVAKGLT.....SVNKSLK.KG-GRILASLREIPYVARPEALDILDETEEAGFS-ILKVGK..PSELI.YNAKVDR.YHAGIVAPGGL..NPIAAIKEAGIPVEAKAVETLMDISEME-e.................................................
D1YUP9_METPS/8-247                  ......mm--FTNARIEEIMYNVTFNPKTRDGDIVVNLSVVD.......KNNLDEVLELFRQVMYS..GLSVCSYVKLFDEGETf..sGYRVAPGKAGIATACSITIDGVFLKQGIPVRPKFGGIVQVK..DR.QPIRFTDMIRYDSTTIDPLEVLMSQELT.....SVKEMTR.TGSGKVLANFREVPMTAKDDVDHTINRLLTAGFYGILEVGE..PNTPV.LGVDVDR.DHMGVIITGGT..NPMAAVQESGIPIVTKAIKGTLDFREMKK..................................................
A6UTI8_META3/83-310                 ........IGSVFSQIMDKLYLSNF-----PTKVIINKTTIE.......-GDYAEIKNLALKVMEH..GYSIGDYMNISKECNA...nIKNDNDDLITVETLCSITFDNFLLKNGILSNPKYGGIIKFE..DY.EPAYFDGTIDFKKTSIDPLDAFISRGKT.....DILGIIE.NGEGYIPANFRVIPKSTKDKFKNL---LNRDLLNGVLSYGE..--ENV.LGIDLNE.NEIGVALVGGL..CPICPAVELGHVVNIGAATSLTDLSLMEK..................................................
K4MBG7_9EURY/85-324                 ........LGFIITRIEELIYRTDYDLKTGKGNVIVNVTYID.......KDDFDNAIDVTRYAMSQ..GATISSRIAVFEEDSTe..fDIYVPEGQIALATVCSITFDGLLLKSGIPVSPAYGGLMQIE..NH.EPEGFIDLISYNGTSIDPIKLFLRRKST.....SVLQTFD.TGSGKMLANMREIPAAAASRALEVIELAKKADIQGHICIGE..PGEEV.FYAPVSR.GMVGIPVMAGI..NAVAAVEEAGIKVETLPVSTVVEYRRMK-q.................................................
B8GJM0_METPE/83-313                 ........IGFIISKLERLAFRSTFNPITGTGDVAYNLSTIP.......EERVDEVTAAFDQVIDA..GCGFFNAYRIIDRHPK....---VPAGHVGFITLCSITMDGVFQQHGIPVKVAYGGTLAVE..NR.KAIEFTNLIGYRGTTIDPLQLFISSGLT.....AIKPLVT.TRSGIALANIRQVPLPAESQVSDLINAMRNNGFVLPVEMGQ..---TV.FNVPPDP.HRISIVSYSGM..NLIGNCVELGIPIKTEIGAGNIQFSKV--v.................................................
NRPR_METJA/86-305                   .......l-GSIYSNILEKTISANY----RFGYVVINRCQV-.......YADFNDVLKIIKSVYES..GLAVGDRVGIIDREKF....--------VEINTLCSLNFDNILLQNGIFPLHVCAGVVKYE..DG.KPVEFKEIIDYKSTSIDPLRAFIEKKET.....DVMGIIE.NGEGYLPANFRYFGVEFLERFETI---LEIDELKCIISYGT..--ENV.LGLDVGD.DKVGVALIGGL..TPIAPFVENNYCVEICPMSSIVRLESLH-k.................................................
#=GR NRPR_METJA/86-305        SS    .......X-XXXXXXXXXXXXXXXX----XXXXXXXXXXXX-.......XXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXX....--------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XX.XXXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXX..--XXX.XXXXXXX.XXXX---HHHH..HHHCC---BTTTTB-EEEEEEEEEEGGG-H.................................................
A0B6Y5_METTP/84-308                 ........IGFVNTLIEEYMLRTTFDFAS--GDLVANISLID.......RNDLERALEIMEMVAES..GYS-GDLVRVHHKDDC....--------AEIGTVCSITVDGLLLRAGIPVNTTFAGVLEIR..NG.EPCRFSDLIAYAGTSIDPMRAFMARRIA.....RVMDAVR.SGSGKVLANVREVPVSALEDAMRVLDRA--RSIVGRIAVGA..PGDDV.LGCPVAP.GRVGIAICAGV..NAPVAVAECGIRIRTCPISTLIPCGEMS-r.................................................
NRPR_METJA/322-538                  ........IKTALSKMFNAMAKVTYDIDEADGDVIVNTAFID.......KKYLDEAFDILKEAYKK..GLGISDRFGIVEENDR....--------IKIQTICAVTLDGIFLRNSVPLIPKYGGILEIT..ED.-KERFIDIIGYDGSSLDPHEVFFNF---.....------V.DCEKTFLAGFREVHRVAREKLEEVLKKL---NWNGIKAIGE..PNNEL.YGIGVNK.DMCGVVTMGGI..NPLVLLKENEIPIELKAMHEVVRFSDLK-s.................................................
#=GR NRPR_METJA/322-538       SS    ........HHHHCC---BTTTTB-EEEEEEEEEEGGGHHHHH.......HTT-SSSSEEEEEE-SS..EEEEE-CHHHHHHHHC....--------EEE-SS-EEEEEEEESTT-SS-HHHHCGGG--S..EE.-EEEEEETTTHHHHHHHHHHHT-TT---.....-------.-TTEEEEEEE-TTHHHHHHHHTT---EE---EEEEEGGGSE..XXXXX.XXXXXXX.XXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXX-X.................................................
H1YYZ9_9EURY/85-316                 ........VGFVISKLEKLAFRSNFDPETCTGNVAYNLSFVP.......EEEEEGVAKAFDDVIGA..DYGFFTSYKIIDSDPR....---IPKGHVGFITVCSVTMDGILQKNGIPVHMAFGGTMKIR..DK.IPVGFTELIGYRGTTVDPLILFINSGMT.....SISETTK.SGNGIMLANIREIPESSEDSVMSIASSMQKAGFRFPVTTGC..---GV.MNIRPDS.YRTSIVAYTGM..NLIGCGIERGYNIKTEIGAGNIPYSKFE-l.................................................
K4MEK7_9EURY/7-246                  ........IQFTSAKIEDLMFRTTFDPRTREGDVIVNLSLIS.......SKDYDDVIKIFSMAMNS..GLTVSPMIKVLHEGDMi..gSMTIGKDEVGFATVCSITIDGILLKAGVMIKPKFGGLVEIR..EG.LPVRFTNVLTYQSTTIDPLEVLMSQELT.....SVMEMLR.TGTGKILANLREAPMIARDVIDSTLSDMVEAGITGILEVGE..PNTRI.LDVPVER.DHLGIVVIGGT..NPMAIVQEHGISIRTNAMSTLMSFSEMKH..................................................
D7EBR2_METEZ/12-251                 ........VQFTLSKIVNLMFSTTYDPKTGKGDVIANVSIIN.......KHDLNRVLEIFKTAMMS..GLTVSPFIKILHEGESi..gDLTIKEGKIGLATMCSITIDGILLKRGILVNPKFGGLVQIE..EG.SPVRFTDVLTYASTSIDPLEALMSQEIT.....SVTQMIS.TGSGKILANLREVPIAARYDIDHVLSDIMDAGLSGILEVGE..PNRKI.LDVPIER.DHLGIVVIGGT..NPMAIVREHGIPIETNAMSTIVDITEMS-d.................................................
L0HBK6_METFS/5-244                  ........LKFVNNKIEDYALQTTYDPAKNEGSIVYNLSLVK.......TGDLEFAISVLKDANRS..GISMSGLVKFLEPEKKi..sGLTIPPGCTGICTMCSISFDGILIRHGIPVRPIGGGIVEIE..NR.TPVRFTHMILYEHTTIDPLQVLMSQKTT.....SVTDVMR.KGSGNILANIREFHMEAEPLVGQVLDELSGSNFSGVLDVGM..PNVPL.LGVPVSP.QFIGIAAIGGT..NPLAAIREADRWIQVQAMKGLIDVSEMD-e.................................................
Q8TYG2_METKA/85-323                 ........VGMYISLIEEMAYRCSFDPEVMKGKVVCNISVVK.......REHLDDFLDAVVETYRA..GISPSPLVAVKEDLSD...hDVEVGEDEVAVLTVCSVTIDGVLINRGIPVTPVCGGLLYLE..DG.EPLGMQEYIKYEGSTVDPLHVFVAKGMT.....QVERVLE.TGTGLVPANVRYVPWAALEDVEHVERELEKADIRGIVDVPK..VEGEI.LGIPLPP.RSLGIVAYGGL..VPVALLEERGISTRTYPTRTLVEYSSLE-d.................................................
D7E9U3_METEZ/85-323                 .......l-SFVSTRIEELMYRMNFDPETEEGNVIVNISLVD.......NNDLEDALEIIKIVTAN..GITISPRIQIFDENSD...sKIDVPEGKTAIATVCSITIDGILLNQGVPVEPAYGGTLNIK..NN.EPVNFQDLISYSGTSIDPIKIFMSRKTT.....SVLDVLD.TGTGKILANMRTIPASASEKALDVINRINASEIGGVIRTGE..SGEYV.FGAPVDF.GMSGVPVYVGT..NVICAVEEAGIDVATYPVSTVLEYSNMS-k.................................................
Q12VH9_METBU/85-323                 ........LGFVITRIEELIYNTNYDPISKEGNVIVNLSTLD.......KNDFDNALDVMKYAASG..GMCISPNIKIFEEDSD...sGVYVPEGSVGIATVCSITYDGVLLRNGIPVKPVYGGILEME..HN.DPVQFRDLISYSGTSIDPVKIFMIRHAT.....SVLDVLD.TGNGRILANIRTIPSSAVDKAQEVLHQLEASGLGNVMNIGS..SAYDL.CGAPVEE.GLSGILVGVGV..NMISAVEEAGIPVSTSPVSTVLDYKVMS-k.................................................
F6D855_METPW/84-314                 ........VDFIFSKFEDMIYQTTLDPSKGKGAVVVNNSTFT.......--YSKKVMDIIEKVFKM..GIAVSPYTNTYPIKDG....-----NNKIKVETVCGTTIDGMLLNQGIPVIPQYGGVVKVE..DH.VPVRFTELIAYKKTSMTPLEAFTDREMT.....SVLQVID.EGNGLIPANFRIIPASAKTQAMEIFKDLEKIGIFGLLKIGD..DGESV.LGIPVDD.NMVGIAVIGGI..SPLCAANEAGFDVDIKLAENTAEFSEMK-s.................................................
D8K457_DEHLB/90-329                 ........VGFVSDKIELLAYQSTFDVNRQEGLIPVNISLFP.......GNQFGDAMKVMAPIFRA..GICVSDLIAVEQAGGNl..gGMPVPEGYIGLATVCSITINATLLKSGVPMDSRFGGTLQYR..QN.RPWRFTDLIHYTGSSLDPSEIFIASRMT.....GVTETAR.RGSGKILANFREVPAMSLPMVRDLMFGLEKAGIRGLVDIGE..SGKPV.CEVPVGL.NKVGLILCGGL..NPVAAAAEAGIATRNRAMSGLMDFHRLR-r.................................................
Q8TSH4_METAC/8-247                  ........IQFTSSRIRDLMYMTTFNPKKMDGDVILNLSVIE.......KKDLDDVLGIFKMVISS..GLSVTPYVKVISEGESi..gNLTVGKGKVGIGTVCSITIDGVLLKAGIPVHPKLGGVVQIR..NG.IPIRFTDVLTYVSTTVDPLEVLMSQGIT.....SVSEMLR.TGSGKVLANLREAPMVARDAIESTLSDLLDAGFSGILEVGE..PNTRV.LDIPIER.DHLGIVVIGGT..NPMAVVQEYGIPIDTSAMSRLIPFKEMS-r.................................................
A7I5N3_METB6/83-314                 ........IGFVISKLERLAFRSTFDPATGTGDVAYNLSFVQ.......KDDLDRALVAFDEVNRA..GCGFFNSYRILDDDPR....---VPSDCVGVITLCSITMDGLFQRNGIPVKMAYGGRLEIE..NN.VPQRFRDLIGYRGTTIDPLELFISSGLT.....SIHDFTR.TKTGIALANVREVPRSAQGEIKQIIRLMNDCGFIYPVTMGN..---HI.FNLPDSS.YRLSIVAYSGL..NYIGNCVEQGIAIRTEIGAGNIPFSKV--ad................................................
E1RE52_METP4/108-338                ........IGFIISRLEKLAFKSDFNPETGRGNVGYNLSVVP.......EDQVNGVSGAFDEVIES..GYSFFSRYKIIDTDPR....---IPSGYAGFLTVCSITMDGVLQKMGVPVRMAYGGVIDIK..NG.KPLGFSNLIGYRGTTIDPLSLFITSGNT.....SIGQTCA.EKAGSVLANVRQVPQDAADLVSEGSRLMRECGFLFPVDMGS..---GV.LNTPVDP.CRISLIAYSGM..NLIGNAVEKGFELRNEIGAGNMPFSFF--e.................................................
NRPR_METMP/81-299                   ........IGSVFSQVIEKLYLSDF-----PSKVLINTAKFE.......-GDYKTIKEMVLRSFEA..GYSVGDYLNIKKKGNT....--------VSVETLCSITFDNFLLKNGIIPTPEYGGIVKFE..DY.EPVNFEGVIDFKSSSIDPLVAFIMQGKT.....DVIGVIE.NGEGLVPANFRVIPKSSEKQFETI---LKKDMLNSVLAYGT..--ENV.LGMNLNP.EQIGVVLVGGL..TPLCVPHESGYTADISAATQLKDISSMEK..................................................
H1YZ00_9EURY/6-245                  ........LKFVNHKIEENATKVTYRPAENTGTVIYNLSLIE.......SGDYEFAIDIFREAFRA..GLVVSDRVSFLKEGDEi..eSYKIPEGKTGICTICSMTLDSLLLRKGIPINPIGGGMVEIE..NM.IPRRFTAMLKYEYTTIDPISVMISQGNT.....KVTEVIK.TGNGSITGNIREFHMEAESTVFGVVEELNSSGFTGVLDVGA..PNTSL.LGVPVTP.DYQGFAMIGGT..NPVAAIIESGRSAEVRSMKGLIDISKI--ny................................................
F7XPA1_METZD/85-323                 ........LGFVINRIDELIYLTDYDLNEKKGNVIVNISHID.......KNDIDASIEIMKYAADS..DIGISPKIRIFEEDSD...sNITVPPGSVAVATLCSITFDGLLLKGGIPVEPYYGGTLQIK..DR.DPVKFLDLISYNGTSIDPIKIFMSRRST.....SVLNIMD.TGEGTMLANVRYIPTSAREKADEILKKAGLSDMAGTITIGG..SGEEL.FGAPADI.GKSGIPIFVGV..NTIAAVQEAGIKVNTYPISTILDYSTMY-k.................................................
Q2NHI2_METST/324-552                ........VSFVLNKIYNLLSTVNFDIESGEGDVIVNVSFVD.......RNNLDTSLEILSKMYKSkpEFCIGNRYSLVDGPDN....-------KVGIATICSLTIDGILTKHGISSFPKYSGILDIY..GN.-SRRFIELISYKGSSVDPHEIFINKNMC.....ELN--VS.GDSCKILASVHSVPYIARDKTVDILDKLGEYGFE-VLNIGK..PNEYT.YNAKIEK.YHFGYVLAGGL..NPIAAIKKEGIPTDVKSIETMKNFNSFE-e.................................................
I4BXA1_ANAMD/91-331                 .......i-GLSSMETEILITKSDLDLCSNKGKAIVNITAVQ.......EERFDEAVSILKEVSNS..NIIVSPLVAFLEGGQRi..wNYRVPEGHRAILCLSSANYDVVLRRCGVHVETVATGLFRIQ..DH.KYKGFADIISHSGTTLSPGELLVRGGFT.....DVMSAVR.TGRGYVTAAIKTFPSFMYETVVEAIKNCKNDNISGLFELGY..LMPQK.YQMSIKDrTRGYMLVFGGA..NYFAPLVEWGITSALSIASGLFNIQDMH-v.................................................
G7WQV7_METH6/7-236                  ......lv--FSLSRIENLMHQVSFDPRRMEGEIITNTSLVD.......LKMLDPTLRIFRDVIES..GLAVSPYLKVETLGTK....--------AKIMSACSITISGVLLKAGVPIRPRGGGVIEVI..DR.EPVRFTDMLMYWATTIDPIDVLISQELT.....SVVEMME.TGSGRILGNLQEAPMIAAERIEERLDLLAEAGFSGVLDLGD..PNMNV.LGVSVER.DHVGLSLVGGT..NIVAAAMSHGIRIETESISSLTKIQEMT-h.................................................
F6BCA0_METIK/84-303                 ........LGSIFSQIMEKLYLADY----RNGIAVVNKSIV-.......YGDHNEIKDTILKVLEF..GLGVGDKVNIVEEKNY....--------TRIETLCSVTFDNWLLSHGILPIPKYGGIVKFE..DY.EPVQFEGVINYKSTSVDPLEAFIMQRKT.....DVWGVIE.NGEGYVPANFRVIPKEAKEKFEKL---LKKDTLNCILSYGE..--DNV.LGLNVEE.DEIGIALVGGL..SPVAALVEKGYYVELNAASTIKKVSFMEK..................................................
F4BZP9_METCG/89-328                 ........IGFVNTRIEEYMYKSNFDPCSGQGQVIANTSIVD.......KADAEEVLDMLGRAFDQ..GYTISRRVLILDEGDAi..sTLEVPAGSLGLATVCSITMDGILMKKGIAVLTSFAGLAKIK..EK.QPIEFTDLIAYAGSSLDPVKVFMGRKVT.....SVANAIR.LGSGRVLANVREIPVAAAGHALELLEASRSAGFGGLIKVGG..PAEPI.LGCPVAA.GKIGIAFYAGV..NGTVAAEEMGARMKTLPISMLVDYSRMT-d.................................................
G2MN03_9ARCH/87-270                 .....laq---VRERIATLQSRVSYDPADDAGDLVVAEAVVP.......DEQFGDALADLRALEAA..GM--GPVVTAAEPIEG....-------GYRLAFPSSVTLDGSLLVRGIRSELQTAGLVEYNpdAG.AVTRYVDAISGEGSTMDVVRLLIEADRT.....GVDAVVE.GETGLLIVDNREFPLTRYDETNGIAHAL-RETLGGVLSISR..PRE--.-------.-----------..-----------------------------dgp...............................................
H3ZNZ7_THELN/85-325                 ...igips-----IEIEKLITNSDYDIDKNKGKVMVNAIMVP.......KDKYDLVVPLLLDISKT..NVITSPLLAILDEKESi..wHFEVKEGHVGILGISSRTYDIIFQKNGICLQSTATGLYQLE..NN.TPKGFMEIISHLGTTISPGELLIRGGYT.....SVHKVAS.TGSGYVTAAIKTFSSFLYEDTIKILEKLKKNNISGIAEHSCviPENKR.VNI-MDK.NKGYLVVYGGA..NYFAPIVETGVSKKLEIARDLYDIQKMKK..................................................
A7IAT0_METB6/5-244                  ........LKFVNHSIDDYAMQVTYDPAKGTGKVVYNITLVK.......NEDFEYAVSVLRDAYKT..GVSVSGLVRFASSNEKi..eDFVVPDGFTAICTVCSLTFDGLLIRRGIPINPIGGGVVEVE..DR.SPIRFTHIILYEHTTIDPLQVLISQQIT.....SVNDVMR.KGSGNILANIREFHMEAEPLVGQVLDELVESSFTGILEVGV..PNIPL.LGVPGSP.QYVSIAAVGGT..NPIAAIREGGRFVQTQALKGVMDVEKF--ve................................................
E1RE54_METP4/5-243                  ........LKFINHQIEENAIKVTYNPTENTGKVIYNISLIK.......SEDLDYSIDIYNEAFHA..GLCLSDRVRFAEQGCKf..gDYKIPAGHTGIITICSLTLDALLYKKGVPLNPIGGGLVEVR..KM.TPRRFTAMVRYEYTTIDPITVMISHGNT.....SVQEVIH.NGNGTITANIRECHMEAEPSVFEVLDDLNEAGFSGILDVGV..PNTSL.LGVPVTP.NYMGIAMVGGT..NPAAAIMESGRGVEINSMKGLIAISEI--g.................................................
A0B970_METTP/33-262                 ......lv--FALGRIENLVHQVSLDAKKGTGRVITNRSLVA.......RDDLHEALEIFKDAIDS..GLAVSPLVRLEDVGER....--------FMIHTVCSMTIDGYLIKHGIPVRPKGGGLIEVI..DR.ETVRFTDIIMYWATTIDPLDLLIAQELT.....GICEMMR.TGTGRILGNLHEAPMIAHDTIEDLLDELRDAGIMGVIELGD..PNMDV.LGMPVER.DHLGVALIGGT..NPAAAAVEFGLDIETASISGLTEISEMC-h.................................................
D3SUV1_NATMM/226-362                .ldiqsgg----------------------------------.......-----------------..----------------....-----------------------------------------..--.RIVRYVDVINGEGSSIDVISLLIESGRT.....DVRSVLEgEGSGLLVGDGRQFPINRYEEARDL-AVASRDAIGGVLDFQR..PREQ-.-------.-----------..-----------------------------dklpngssawafgsltyvgvgelllsalseydvttewdtlygtaersmfe
D5VS72_METIM/82-299                 .......l-GNIYSNILEKVILSDY----QAGLVVVNRSIV-.......YTDYEKALSLIKKVYEN..GLAIGDRVGIVDREKY....--------IELYTLCSLNLDGLLVKNGIPVYHICGGIVKYE..NY.EPVEFKEIIKYKATSIDPLLAFIERKKT.....DVLGIIE.NGEGYLPANFRVIGANYRERFERIIKKL-----DGIISYGS..--ENV.LGLDVGE.EHIGIVMIGGL..SPIAPFVEKDIPTEIIPMSSIVRLSSLH-k.................................................
NRPR2_METMA/8-247                   ........IQFTSSRIRDLMYRTTFDPKKMDGDIILNLSLID.......KKDLDDVLGIFKMVISS..GLSVTPYVKVISEGESi..gDMTIEKGKVGIGTVCSITIDGVLLKAGIPVNPKLGGVVQIR..NG.IPVRFTDVLTYVSTTVDPLEILMSQGIT.....SVSEMLR.TGSGKVLANLREAPMVARDEIESNLSDLLDAGFSGILEVGE..PNTRV.LDVPIER.DHLGIVVIGGT..NPMAVVQEYGIPIDTSAMSRLISFKEMS-r.................................................
Q0W3T7_METAR/85-324                 ........IGFISTRIKEIELMTTYDPATNTGEVAVNICYIP.......KDRFEDALGAIKRVVNA..GYAISPRIKIVDEGEEi..lENDVPLGSVAFASVCSITLDGVLLKNGIPVNLKYGGILWIQ..NG.EVQRFTDVIDYSGTSINPMSVFTSRKMT.....SVNKAIE.TGTGGVLANVREIPVAAREKAQELIYQMKAAEFLGVVSGCE..PVRPL.LGVPIEL.GKCGIVEYSGI..NPFAAFVELGIKTRIMPLATVINIRELKK..................................................
D3S1I8_FERPA/83-323                 ........IGYSISRVHECVFYSDFDVESGEGKVVANLAIFP.......REYLEEVLDMFYRCWKK..GLTFSDKVIVDENIPF....---IEENEVGLYYISSFTLDAILYRNGIVSSPRFAGSIEIS..NF.NFVRFTQVIGLEESSITALDLFIQRMYSdkdeeSISNLLE.KGEGEVYGMYREIPFVAREKTIEILEKLKEYGISPLYVIGE..LDKSV.CGIPPKGvNKVGLVCVGPS..TPVGILRALKVPIRVHISSEIIEFSKFK-s.................................................
D5EGZ4_AMICL/86-326                 vgtpsfet--------EKLSSFYSFNGEKKKGFIVANCLLLE.......KNKLSIALQELKKAAFT..NVWVSSLLGISKEPEKl..wKCDLPDKYVGLVCVSSRNYDVALQKKGIYVETSATGLYSLK..NF.TPRGFTEIISHTGTTLSPGEILIRGRYT.....SVCRLAE.TGEGLVTAAIKTFPSFLYKELQEALAHLDPSIFSGLIFHGG..LIPPS.YRISSKDrNKGYMVIYGGA..NLFSPLIEKGIATNLSIASSLYDVEQMT-d.................................................
A5UN44_METS3/83-311                 ........VDFIYSKFEEMIYLTSFNYMNRAGNVVVNTSTI-.......--YDEEAFNIIKDVFKS..GLCVSPYINLKEGNSK....------EEIQIKTICGTTIDGILLNEGIPTIPLYGGLVKIR..DY.VPTKFTELISYKKTSVTPLDAFVAPGMT.....SVLDVIN.TGTGTIPANLRLIPSVGRERALNIINKLEKIGIGGVMAVSE..EGKNM.LGVPVPE.GMVGIAVSGGV..TPFCAAQELGYDIDIKIAEEIEGFETLS-p.................................................
Q0W777_METAR/8-247                  ......mm--FTDARIDSIMYQVTFNPKTREGDIIANLSLVD.......KKDLDETLEIFRQVMYS..GLSVCSYVKLFDEGDIf..sGLTIPAGKAGITTVCSITIDGVLLKSGIPAKPIFGGIVQVK..DR.VPVRFTDSIRYECTTIDPLEVLMSQDLT.....SVREMMR.TGSGKILANLREVPMAAKDDVDRTINRLLTAGFYGILEVGE..PNSPV.LGADVSR.DHMGIIITGGT..NPMCAAQEAGIPIITKAIKGVLDFHEMKK..................................................
D3E025_METRM/333-560                .......p--FILTKSLNRVNQVDYDIETGHGNIVSNISYLQ.......KEDLDDAISIMKKTYKAlpKY-MNSHFSIVDHPDD....-----KSKVGIATVCSLSIDGILIKNGIMSTPQYGGLLELG..--.KPPLFVEMISYNGSSIDPHKIFIFKDLT.....QIAK--R.KNPKKILASIKEVPYIARPETEEILEKISKEGFS-IFKVGK..PRELV.YNAKVDN.YNFGIVTGSGL..NLIAAIKEKGINIEAKAVETVLPIEDMS-l.................................................
F6D855_METPW/333-563                ........VKFLLSKAWNLIYNVDFNLETQKGKVIANVSYVK.......NEDLEDALQIFDRVMASkpNYCTNKFFKIIPDVEP....------GKTGIATICSLTIDGILTKNGIPAIPQYGGILETE..GK.EP-RFIELTAYSGSSLDPHEVYISKNMT.....SVLDSL-.NGKGRILASLREIPYIARPRAIEVLEDVKEAGFS-ILKVGK..PSELV.YNAKVEL.YRAGIVAPGGL..NPIAAIREAGIHVEPKAVETLMNISDME-e.................................................
O27611_METTH/332-560                ........VRFLLSKAWNLINRVDLNPEDLSGRVIANISLIS.......RDDLDYALEVIGQVLSErpEFSTLPMIGVTDEGGM....--------AGIATVCSLTLDGVLIKSGIMSTPKYGGLLEVG..GR.AP-RFVELTAYSGSSLDPHEIYVSKNMT.....AVLEAL-.NGQGRVLASLREVPYLARDHAEGLIEELSEAGFS-VLKIGV..PGEIL.YNARVEK.YHAGIVTPGGL..NPLAAVREAGVEIRMKAIERLMDLREFR-y.................................................
B8E0N2_DICTD/84-325                 ........LGFIISKIENLAYQVTLDRSTGKGKVILNLSIIP.......KKDLQKSLNIMKDILKK..GYGISEKIIIFDKKEEeiipGVIVPEKSVILGTVCSVTIHGVLIKNGIPVNAKFAGVLEVK..DH.EPTRFLEAITYNGSTLDPLEIFIKSKMT.....SISSVVK.KKEGRVLATFREIPNSAREDAQNIIEELKEIDIKGKIYLGK..PNQEL.FGVPVTQ.GTSALVIVGGL..NPIAGIIEADIEAENKAMSILYNYEDLK-p.................................................
J1L096_9EURY/85-317                 ........IGFIISKLERLAVRTTFDPATGTGDVAYNLSYAP.......YDEVDRVQKAFDEVIAA..ECGFFNGYRIVDNDPR....---VPDDHAGFITLCSVTMDGVMQRQGIPVEMKYGGRLAVD..AAlEKSRFLDLVAYRGSSIDPLQLFISAGLT.....SIHTYVT.GGAGTVLANVRQVPLPAKEKVFEIASAMRASGFRFPITTGE..---QV.FNLTKEP.YRLSIVSLSGM..NLIGHAVEVGCQIKTEIGAGNIPFSR---vls...............................................
G7WN74_METH6/89-328                 ........VGFVNARIEEYMYRSSFDPGSENNRVVVNTSLLD.......KRDSERALAAMKAVFDA..GFAVSRRVLIQDEGEEm..gGAAVPRGFLGISTVCSITVDGMLLRGGIPVNTTFAGVVDVR..EG.SLYQFTDLLAYAGSSLDPIRVLMSRKAA.....RITGAVK.TGNGGLLANLREIPVAAIGQARELLEMAKGAGIDGVMRISE..PGEPN.MGCPVGA.GKVGIALCAGV..NAVLAAEELGAEIRTTPISSIQEYGRMK-e.................................................
L0HK37_METFS/83-314                 ........IGFIISKLERLAYRSTFDPAAGTGDVAYNLSMVP.......NEHAEKVTTAFDEVIRA..GCGFFNSYRIIDHDPR....---IPHGYTGFITICSISMDGVFQRQGIPVRMAYGGRLEIE..NG.SPREFKDLIAYRGTTIDPLELFISAHLT.....SISSFAR.SKSGITLANVREIPCAARSRAEETIRQLNSCGFVFPVTMGN..---HV.FNLPPNP.YRLSIVAFSGL..NYIGNTVEHGIPIKTEIGAGNIRFSKI--le................................................
D7DT16_METV3/81-310                 ........IGSISGNIYDKLTKGNY-----PETVIVNRGTFNlkensesKEELKKLKELILLSFKH..GYSTGNYLKMEQLDKK....---DNNLRLNVETLCNINFDNYLIKNGIMSMPKHGGIVKYE..DN.KPVNFKGVIEFKKTSVDPLIAFIMQKKT.....EVLSTIE.NGEGYIPANFRVIPKSKLDEFKQL---LKKDNLKSVICYGE..--NNV.LGINLND.EEIGVALIGGL..TPLCIPVELGYSLDINSTTKI--------eanpni............................................
A0A0A7GEH1_9EURY/80-314             .......l-GEFSEKIEFNVYNCTFNLLEMRGTVPTDIAVID.......KKWYENTREIILKMAEA..PFLISNLIVLRDEGETl..gEYEVPEGNFALVVISNTLFDVIMRNAGINLYPEFAGLLYWK..DG.-SRGVSEIISYRGTTLSPGWLFLRAGMT.....RVWDAL-.DGEGYLIVAIRSFSKHAVDIARMEIEMAESKDIRGVVELSE..---DK.NGFPFFG.MKASMTILAGL..NYLAPLFENGIPGELMVNDILVDIREFA-d.................................................
Q2FTS7_METHJ/83-315                 ........IGFVISKLERLAFRSTFDPATSTGDVAYNLTIVP.......DEILEPVSQMFDKVRDA..GCSFFSGYSVIDRDPR....---VPSGHTGILTVCSITMDGVFQHNGIPVKVAYGGTIQIE..DK.KPVRFMNIIGYQGSTVDSLQLFLGAGLT.....SINQYIN.TGSGILLANVRQIPGAAEERSQTLIQEMQACGFRFPLMMGK..--GRI.FNLLTDP.HRISLVSYSGM..NSIGGAVEAGYKLKTEIGAGTIPFSRV--vd................................................
F8F2H0_TRECH/85-324                 ........VGYMSARIDQMTYTMDFDLPRRKGTVVINLAIIK.......QEEFLRYLPQVELVFEK..GYAMGTLVSFLHEGERl..gSYTIPTGHIGFCTVCSVTLNGVFLKYGIPTRSLFSGLLQLE..QG.QARRFVELISYDGTSIDPLQLFIRGKMT.....DYMGAIR.DGNGRIGAGFREIPGESYQLAQDLARQLQDIGLGAFLKIGR..PSRDL.LNVPVHE.GCCGLIVIGGL..NPVAVFEESGISVSYNALAGYMEYNQL--fh................................................
F4BX01_METCG/4-233                  ......lv--FTLARIENLMHQVSFDPAGMKGKIITNTTTVR.......KEALDETLAVFYDTINS..GLAVSPMIKVIEGKGR....--------IKIKTACSLTLCAVMLKHGIPVHPKGGGLVEVV..ER.EPTRFTDMLMYWATTVDPIDVLTAQGLM.....NITGMMR.TGNGRILGNLHEAPMLARDKIEDVLEALAQAGFAGVLELGQ..PNMNV.LGVSVER.DHVGLALVGGT..NLMAAAKECQIDVMHESISDLTDISELKH..................................................
F6BCA0_METIK/320-536                ........IKSVLSKMFNNMAKVTYDINKEDGNVIVNVGYVE.......KKYYDDVVEILKEAYKK..GLGISDRFGIKEEDGL....--------IKISTICASTLDGILSNYGIPIIPCYGGVLEIG..EE.-KERFIDIISYEGSSLDPHEVFFNK---.....------V.DCETSILAGFREVPMCAREDLIDLVKVL---GWNGIKEIGR..PNNEV.YGVSVEK.NMCGVVTIGGM..NPLAMIKEHEIPIEIKALHEIVKFSELV-k.................................................
A5UN44_METS3/331-558                .......p--FLLSKSWNLIQKVNFDVETRKGDIIVNVSYIN.......KDSLDKAIYIMKETYES.nPKYINPYYQLVEHPTD....-----YTKIGIATICSLSIDGLLINNGIMSNPKYGGLLELN..ES.--PLFIDLISYNGSSVDPHKIFIAKNMT.....SITRNI-.-GSNKILASLKEIPYISRDYAVHLLNILKNIGFS-IYKIGK..PRELT.YNAKVDN.YNFGVVAGSGL..NLIAALKEKGIDVEVKAIAKLMKFEKME-r.................................................
D5E812_METMS/8-247                  ........VQFTSSKIEDLMFRTTLDLKSMQGDIIVNLSIAD.......ADDFVDVLEFLKLTFNS..GLSVSPFLKILESGDVi..gDLTIPEGKVGIATMCSMTIDGVLLKSGIMTNPKFGGVVQIR..NG.LPVRFTDVLTYASTTIDPLEVLMSQDIT.....SVTRMLQ.TGSGKILANLREVHLAKRDEINSVLSGMMDIGINGILEVGD..PNSRV.LDVPVER.DHLGVVVIGGT..NPMAIMKEQGINIRTNAMSTLMDINSMN-k.................................................
Q12VW5_METBU/8-247                  ........VQFTSSRIEDLMYRTTFDPVNMTGELIVNQSLVK.......EKDLEAVLEVYNLVIRS..GLSVSPFLKIIKSGETi..gDLKIAQGDVGIATVCSITIDGVLLKGGVMINPRFGGVVQIK..NG.QPVRFTDVVTYASTTIDPLEVLMSQDIT.....SVTKMLR.TGSGKILANLREAPLVARDDIDHILSDLMEAGLSGIMEVGE..PNTRV.LDVPVER.DHLGVVVIGGT..NPMAMAKEQGFEISTSAMSALIGIDSMKH..................................................
U6E9K2_9EURY/84-315                 ........VDFIFAKFEDMMYQTTLDPTTGLGKVVVNSSTFS.......--NNEEIMDIITNVFSK..GIAVSPYVKIIPSSES....----DESKITMETICGTTIDGMLLKAGIPVVPRYGGLVEIK..NY.IPQTFTELIAYKKTSMTPLEAFTDQEMT.....SVLEVIE.SGSGNIPANFRLIPATAREKALKLFTNLQKIGVSGLLKIGK..PGESV.LGIPIDK.DMVGITITGGI..SPLCAAKEAGYDVNIKMAENTVEFSEME-s.................................................
A3CSY8_METMJ/86-317                 ........LGFIISRLEQLAFRSTFDPATATGSVAYNLSFVR.......EEDLPGVTAAFDEVAAA..GYGFLNAYRIVDSDPR....---IPDGHAGIMTACSVTLDGVLQKMGIPTRLEYAGRIAVD..EN.GSAGFLDLIGYRGTSVDPLHLFISAGLT.....SINRLVT.TRAGVALANVRAVPAAARYRVEVTVGLMEKCGFTFPAGGGI..---GE.FNLPKHP.YRLSVVALSGM..NMVGNAIEKGYAIKTEIGAGTVPFEKI--ad................................................
D3SUV1_NATMM/83-191                 ......le--QIRARIAALTSRVSYDPLEDTGALVTSAAYLD.......EDAVDEALDLVASLESL..PLGPIP-IALEDSAES....----EPGDVRLLVPSSITLDGVLLAHGVNADLATAGLLEYE..--.----------------------------.....-------.-----------------------------------------..-----.-------.-----------..-----------------------------pvavse............................................
D3SUV6_NATMM/199-332                ...aahgg----------------------------------.......-----------------..----------------....-----------------------------------------..--.AIRRFTDVIGDERATVDMVSLLIEARRT.....TVGSALA.GEPGLLVADNREFPLAKYDRAHEL-AVATRRQLGGVIDVRR..PREPGpFPWDEPG.WAFASLTCVGLseCLIARCVEEGIATEWETLARVHD------radlq.............................................
N0BK59_9EURY/87-323                 .......l-GEFSETLEYNMLHSTFNIYTMEGTVPTSVAILD.......KDQADRALEVLSEVLNS..RLATSRYAVLLDEGEIa..gKTEIEEGKIGIGTISSTVMDIIMLNIGVILSVEYAGLLKYE..NG.LPVGVTELINYSGTTISPGLLFIRGGYT.....SVYDVVV.RGSGYAVIAIRNFSPYAIEEVEKEVQLASARGLGKVLTITM..--DRF.FGIPAQ-.KRAMLVFQAGI..NQLAPLYELGFKPVLEINSSLIEFRKF--ge................................................
O27611_METTH/88-313                 ........VDFIFSKFESMIYNTSFNPDTLEGKVVVNTSRIS.......----PRSIETLKHVMRN..GLCLSPRVKLERDGDG....--------CIISTICGTTVDGILLASGIPVIPQFGGLVRFE..DH.QPVNFTELIAYKKTSMTPLEAFTSENMT.....SVLSVIE.EGDGLVPANLRLVPGTGREDAVKILRKLEGIGISGVLKVGE..PGEDV.LGVPVAD.GMVGVAIIGGI..TPLCAIQEAGYRAEIKLAENLIEFQSLK-p.................................................
D3RXS6_FERPA/85-322                 ........IGSFIELREEYAYNANFDPFKRKGLVSLNIGIIR.......KRDLEKSLELIKACMDA..KLAVSRFVKIYEREAG....NTKIPKGKVGIGLVSTSVVDAALIGSRISSFPTFAGILQYS..DW.KPLRFVHAISYYGSTLDPIDLFIRSGFC.....SVKDAVE.RGNGNVPADVREIPLVLRKRAVEIIEQLEKIGINGAVYVSG..AENDA.LGIPVNN.YKAGVVVIAGS..TPLVYLKEKGIDVEIKILAAFERIENLE-e.................................................
A3CSS1_METMJ/5-244                  ........LKFTNHRIEEYALKVTYRPEDDTGKIIYNLSLIE.......SRDLEFALSIMKEAHKR..GITISDRLLVAGPGGQv..aGYTVPDGRHAVCTMCSITLDALLLQRGIPASPIGGGIVEVD..GR.VAQRFTSMILYRDTTLDPLEVLISQEAT.....SILDVMR.HGKGNILANIRECHMEAEQLLGTVLDELSAIGFSGILDVGA..PNVPL.LGVPVSP.QYIGVAMVGGT..NAMAAVREAGKPVVTRALKGLIDIREMD-y.................................................
#=GC SS_cons                        ........HHHHCC---BTTTTB-EEEEEEEEEEGGGHHHHH.......HTT-SSSSEEEEEE-SS..EEEEE-CHHHHHHHHC....--------EEE-SS-EEEEEEEESTT-SS-HHHHCGGG--S..EE.-EEEEEETTTHHHHHHHHHHHT-TT---.....-------.-TTEEEEEEE-TTHHHHHHHHTT---EE---EEEEEGGGSE..XXXXX.XXXXXXX.XXXXXXXHHHH..HHHCCXXXBTTTTBXEEEEEEEEEEGGG-H.................................................
#=GC seq_cons                       ........ltFlho+l-phhapssaD.pptpGpVlsNlShls.......ccch-cslplhcpshcu..GhulSshlplhccspp..........splulsTlCSlTlDGlLl+pGIPlpPpaGGllclc..st.tPhRFs-lIsYpuTolDPlclFlspphT.....SVhphlc.sGsGplLANlRplPhsAc-cspcllpplpcsGhsGllplGc..ssppl.hslsVpp.schGlshhGGh..NsluslpEtGlslchpshpslhchpchp.t.................................................
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