GenomeNet

Database: Pfam
Entry: DUF16
LinkDB: DUF16
Original site: DUF16 
#=GF ID   DUF16
#=GF AC   PF01519.14
#=GF DE   Protein of unknown function DUF16
#=GF AU   Bateman A
#=GF SE   Pfam-B_764 (release 4.0)
#=GF GA   29.80 29.80;
#=GF TC   29.90 29.80;
#=GF NC   29.60 28.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   8948633
#=GF RT   Complete sequence analysis of the genome of the bacterium
#=GF RT   Mycoplasma pneumoniae. 
#=GF RA   Himmelreich R, Hilbert H, Plagens H, Pirkl E, Li BC, Herrmann R; 
#=GF RL   Nucleic Acids Res 1996;24:4420-4449.
#=GF RN   [2]
#=GF RM   16522803
#=GF RT   Crystal structure of the DUF16 domain of MPN010 from Mycoplasma
#=GF RT   pneumoniae. 
#=GF RA   Shin DH, Kim JS, Yokota H, Kim R, Kim SH; 
#=GF RL   Protein Sci. 2006;15:921-928.
#=GF DR   INTERPRO; IPR002862;
#=GF CC   The function of this protein is unknown.  It appears to only
#=GF CC   occur in Mycoplasma pneumoniae. The crystal structure revealed
#=GF CC   that this domain is composed of two separated homotrimeric
#=GF CC   coiled-coils [2].
#=GF SQ   29
#=GS Y104_MYCPN/3-103     AC P75565.1
#=GS Y501_MYCPN/39-113    AC P75286.1
#=GS Y524_MYCPN/40-125    AC P75254.1
#=GS Y130_MYCPN/39-139    AC P75345.1
#=GS Y013_MYCPN/179-256   AC P75100.1
#=GS Y410_MYCPN/39-146    AC P75374.1
#=GS Y138_MYCPN/39-157    AC P75260.1
#=GS G4EM32_MYCIO/58-169  AC G4EM32.1
#=GS Y100_MYCPN/110-181   AC P75592.1
#=GS Y655_MYCPN/97-195    AC P75136.1
#=GS Y287_MYCPN/2-116     AC P75490.1
#=GS Y344_MYCPN/86-194    AC P75434.1
#=GS Y100_MYCPN/39-114    AC P75592.1
#=GS Y010_MYCPN/37-130    AC P75103.1
#=GS Y010_MYCPN/37-130    DR PDB; 2BA2 C; 205-285;
#=GS Y010_MYCPN/37-130    DR PDB; 2BA2 A; 5-85;
#=GS Y010_MYCPN/37-130    DR PDB; 2BA2 B; 106-185;
#=GS Y139_MYCPN/39-154    AC P75259.1
#=GS Y484_MYCPN/2-102     AC P75301.1
#=GS Y204_MYCPN/39-146    AC P75572.1
#=GS Y151_MYCPN/2-110     AC P75035.1
#=GS Y094_MYCPN/39-139    AC P75598.1
#=GS Y368_MYCPN/39-157    AC P75413.1
#=GS Y504_MYCPN/39-125    AC P75282.1
#=GS Y501_MYCPN/110-167   AC P75286.1
#=GS Y127_MYCPN/77-166    AC P75348.1
#=GS Y038_MYCPN/29-115    AC P75076.1
#=GS Y137_MYCPN/43-170    AC P75261.1
#=GS Y013_MYCPN/108-216   AC P75100.1
#=GS Y283_MYCPN/40-115    AC P75494.1
#=GS Y145_MYCPN/37-164    AC P75141.1
#=GS K9TAB7_9CYAN/3-102   AC K9TAB7.1
Y104_MYCPN/3-103                .......eldgkf----..--------....---------------....---A..........TKADLKRVEDKVDvlfelqk....tqgeqikVQGKQIEQLTETVQKQGEQIKELQVQVKAQGEEIKeik.......veqkAQGQTLQLILKALEGINKRLDNLES............................
Y501_MYCPN/39-113               .............EFSG..KFNRQFKLnkpvIPVNTEYVTRKEFNE....YKNS..........NDQRLTKIETTLA..................AQGEQINKLTQTVEKQGEQINQLVQ----------..............-------------------------vv..........................
Y524_MYCPN/40-125               ......elrkykl----..------KP....-PVKVKYVTQEQFQE....YKDS..........NNQRLIKIETTLA..................AQGEQI-------RIQVEQIKELQIEQKAQGE---..............----TLKLILQTLQKMSDRLDKME-v...........................
Y130_MYCPN/39-139               .............EFSG..NFNRQFKLnkpvIPVNTEYVTRKEFNE....YKDS..........NDQRLIKIETTLA..................AQGEQ-------IRIQGEQIKELQIEQKAQSE---..............----TLKLILQTLQKMSDRLDKMD-vrldkles....................
Y013_MYCPN/179-256              ...........kq----..--------....---------------....----..........----IEQLTETVK..................VQGEQIRAQGEQIKAQSEEIKEIKVEQKAQGEQIKelq.......veqkAQGKTLQLILKTLEKMNERLEKLES............................
Y410_MYCPN/39-146               .............EFSG..SFNRQFKLnkpiIPVNTEYVTRKEFNE....YKDS..........NDQRLIKIETTLT..................AQGEQINKLTQTVEKQGEQIRELQVEQKAQGEQIK..............AQGETLKLILQTLQKMSDRLDKID-p...........................
Y138_MYCPN/39-157               .............EFSG..NFNRQFKLnkpvIPVNTEYVTRKEFNE....YKDS..........NDQRLTKIENKVD..................KLEVKVDKLEEKVDKLEAKVDKLEEKVDKLEAKVDkleek...vdkleaKVDSGFEMLAKILAAINKRLDSIEG............................
G4EM32_MYCIO/58-169             nysidmhgkdgik----..--------....--TVEKYVLKTEFDP....FKKEmle...fkenTNNRLDKIEQLLY..................QNTKQINQLSSKVDKLSEEISNVNLRIDKEMKMIN.............dRIDKEMKNINNRLDK----------emrninlkldk.................
Y100_MYCPN/110-181              ..........vqv----..--------....---------------....----..........-----------VL..................LHGEQINKLTQTVEKQGEQIKELQVEQKAQGEQIKaqg.......kqikAQGKTLKSILQALGGINKRLDKID-p...........................
Y655_MYCPN/97-195               ..........qpg---GpdNPNAGNKK....MPTPEEYVTRKEFNE....FKDS..........NNQRLTKIENKVD..................KLEVKVDKLAEIVQTQGEEIKELKVEQKAQSE---..............----TLQLILKTLQKMNDRLDRMET............................
Y287_MYCPN/2-116                ............g-FSD..NLNHMEKR....---KSGYVTQKQFSE....FKDA..........NNQRLIKIETTLA..................TQGEQLNQLIKVVILQGEQIKELQVEQKAQGEQIKakgeqikaqseqikTQGETLKLILQALGGINKRLDKVD-p...........................
Y344_MYCPN/86-194               .......qpggpd----..DPNSGNKK....MPKPDEFVTHRQLQE....FKKDllvelheifpTKPELKRVEEKVD..................VLFELQKAQGEQIRIQGEQIKELKVEQKAQGE---..............----TLQLILQTLQKMNDRLDKIEG............................
Y100_MYCPN/39-114               .............EFSG..SFNRQFKLnkpvIPVNTEYVTRKEFNE....YKVS..........NDQRLTKIETTLA..................AQGEQINKLTQTVEKQGEQINQLVQ----------..............-------------------------vvl.........................
Y010_MYCPN/37-130               ............w-LKG..VFEEIVKT....-P-GTRYVTHKQLDE...kLKNF.........vTKTEFKEFQTVVM..................---ESFAVQNQNIDAQGEQIKELQVEQKAQGK---..............----TLQLILEALQGINKRLDNLES............................
#=GR Y010_MYCPN/37-130    SS    ............X-XXX..XXXXXXXX....-X-XTTB-BHHHHHH...HHTTB.........-BHHHHHHHHHHHH..................---HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---..............----HHHHHHHHHHHHHHHHHHHC-............................
Y139_MYCPN/39-154               .............EFSG..SFNRQFKLnkpvIPVNTEYVTRKEFNE....YKDS..........NDQRLTKIETELK..................SQGQRIQVVEDKVDRLTEVVMVQSQQIKTQGEAMNarmd......rfesLVLKSLESIGNTLTDFGKRLDVIET............................
Y484_MYCPN/2-102                ............g-FYG..NLNHMEKR....---KSGYVTQKQFND....FKNS..........NNQRLIKIENTLV..................SQGEQISQLIKVSILQGEQINKLTETVEKQGEQIQ..............TQGETLKLILETLQVINKRLDRLES............................
Y204_MYCPN/39-146               .............EFSG..KFNRQFKLnkpvITVNTEYVTRKELNE....YKDS..........NDQRLTKIETTLA..................AQGEQINKLTQTVEKQGEQIRELQVEQKAQGEQIK..............AQGETLKLILQTLQKMSDRLDKID-p...........................
Y151_MYCPN/2-110                .............EFNG..NLNHMEKR....---KSGYVTQKQFNE....YKDS..........NDQRLIKIETTLA..................AQGEQISQLVQIVFLQGKQIKELQAEQKAQRVEFNarmd......rfesLVLKSLESIGNTLTDFGKRFDSMET............................
Y094_MYCPN/39-139               .............EFSG..NFNRQFKLnkpvIPVNTEYVTRKEFNE....YKDS..........NDQRLTKIETTLA..................AQGEQ-------IRIQGEQIKELQIEQKAQGETLK..............LILQTLQKMSDRLNKMDVRLDKLE-s...........................
Y368_MYCPN/39-157               .............EFSG..SFNRQFKLnkpvIPVNTEYVTRKEFNE....YKDS..........NDQRLTKIENKVD..................KLEIKVDKLEKKVDKLEVKVDKLVETVNAQGEDLNnfkve...vrgtlqSQGETLQLILQTLQGMSKRLDSVEG............................
Y504_MYCPN/39-125               .....yelrkykl----..------KP....-PVKVKYVTQEQFQE....YKDS..........NNQRLIKIENKVD..................-------KLVEIVQIHGEQI-------KAQGE---..............----TLQLILQTLQKMSDRLDKME-kridkles....................
Y501_MYCPN/110-167              ..........vqv----..--------....---------------....----..........-----------VL..................LHGEQINKLTQTVEKQGEQIKELQIEQKAQGE---..............----TLKLILQTLQKMSDRLDKME-v...........................
Y127_MYCPN/77-166               ............g-FNG..NFNHMEKR....---KSGYVTQKQFSE....FKDA..........NNQRLIKIETTLA..................IQGEQINKLTQTVEKQGEQINQLVQVVLLQGA---..............-------------------------sklenfkwskkhkdksl...........
Y038_MYCPN/29-115               ............g-FHG..NLNHMEKG....---KSGYVTHKQLDKklevFKQ-..........---DL-----LVE..................-LSEKF-VTKEEFRAQGKQIKELQIEQKAQGK---..............----TLQLILEALQGINKRLDKLES............................
Y137_MYCPN/43-170               ............s-FNG..DFEVVTKK....-P-STKYVTHKQLDQklkeFKQDlmvelhdtfaTKADLRDSEARINqklea.......lvqvvlLHGEQINKLTQIVEKQGEQIRELQVEQKAQRQEFN.............aRMDRLENLLVESIESTNKRFDSIEG............................
Y013_MYCPN/108-216              .....pggpddps----..---EGKQK....VSKPDKYVTHRELDE...kLK-Df........aTKADFKRVEDKVDvlf...........elqkTQGEQIKVQGEQIKAQGKQIEQLTETVKVQGEQIR..............AQGEQIKAQSEEIKEI---------kveq........................
Y283_MYCPN/40-115               ......elrkykl----..------KP....-PVKVKYVTQEEFGE....FKDA..........TNQRLTKIENALV..................AQGEQIRAQGEQLSQLIKVVLLQGEQIKSQGEQIK..............-------------------------s...........................
Y145_MYCPN/37-164               ............s-LNG..VFEEIVKT....-PGKTRYVTHKQLDQklkdFKQDlmvelhdtfaTKTDLKESEARINqklealiqivmvqgeqikVHGEQINKLTQAVEKQGEKI-------EAQGQQIQ..............KVNETLNFVVESLGSIHKRLDSMEG............................
K9TAB7_9CYAN/3-102              .........ltie----..--------....----------QDLKE....YLDR..........FEQKLDKLEQKIDkt..............deKFEQKLDKLEQKIDKVDEKVDKLSIDMATVKTKIDgld........krmE------------------------nqeflsrgvliglivailggfaklfgli
#=GC SS_cons                    ............X-XXX..XXXXXXXX....-X-XTTB-BHHHHHH...HHTTB.........-BHHHHHHHHHHHH..................---HHHHHHHHHHHHHHHHHHHHHHHHHHHHH---..............----HHHHHHHHHHHHHHHHHHHC-............................
#=GC seq_cons                   ................s....pp..Kh.....s.pscYVTpKphsE....aKsu..........ssQRLpKIEspls..................tpGEQIspLsppVctQGEQIccLphc.KAQGE.hp..................TLphIlpsLpthscRLDph-.............................
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