GenomeNet

Database: Pfam
Entry: DUF1780
LinkDB: DUF1780
Original site: DUF1780 
#=GF ID   DUF1780
#=GF AC   PF08682.8
#=GF DE   Putative endonuclease, protein of unknown function (DUF1780)
#=GF AU   Mistry J
#=GF SE   pdb_1y0k
#=GF GA   19.70 19.70;
#=GF TC   20.80 60.90;
#=GF NC   18.70 19.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   22638584
#=GF RT   Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT   phosphodiesterase superfamily.
#=GF RA   Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA   K;
#=GF RL   Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR   INTERPRO; IPR014796;
#=GF CC   This is a family of uncharacterised proteins.  The structure of
#=GF CC   a hypothetical protein from Pseudomonas aeruginosa has shown it
#=GF CC   to adopt an alpha/beta fold, placing it in the Endonuclease
#=GF CC   superfamily/clan of restriction endonucleases.
#=GF SQ   21
#=GS Q4K5W6_PSEF5/2-209      AC Q4K5W6.1
#=GS Q88Q68_PSEPK/2-209      AC Q88Q68.1
#=GS A0A077F3I4_9PSED/2-209  AC A0A077F3I4.1
#=GS C3KE89_PSEFS/2-209      AC C3KE89.1
#=GS S6ARN7_PSERE/2-208      AC S6ARN7.1
#=GS Q888U6_PSESM/2-209      AC Q888U6.1
#=GS G8QCT6_PSEFL/2-208      AC G8QCT6.1
#=GS A0A024HN75_PSEKB/2-209  AC A0A024HN75.1
#=GS I4N134_9PSED/2-209      AC I4N134.1
#=GS M4WS05_PSEDE/2-209      AC M4WS05.1
#=GS A0A077LBE3_9PSED/2-209  AC A0A077LBE3.1
#=GS M1P9G0_DESSD/2-201      AC M1P9G0.1
#=GS G8QKI8_DECSP/9-206      AC G8QKI8.1
#=GS A0A0K1QGL0_PSEFL/2-208  AC A0A0K1QGL0.1
#=GS A0A089WM00_9PSED/2-209  AC A0A089WM00.1
#=GS D7HVN8_PSESS/2-209      AC D7HVN8.1
#=GS A0A089YSX3_9PSED/2-209  AC A0A089YSX3.1
#=GS Q9HVP2_PSEAE/2-209      AC Q9HVP2.1
#=GS Q9HVP2_PSEAE/2-209      DR PDB; 1Y0K A; 2-209;
#=GS W0HF32_PSECI/2-209      AC W0HF32.1
#=GS A0A0N0E222_9PSED/2-209  AC A0A0N0E222.1
#=GS A4XQC0_PSEMY/2-209      AC A4XQC0.1
Q4K5W6_PSEF5/2-209                 ..............DDSDFLRLLTIQAEQANAFLSNARKWERERWVCQRLLQGLNIPYRNDEFTAAGQE.PPDVLFREASFEVFFVLDEGRRLNDEWRDELQRRRSAFSLSQLVRREAKPKRIPASELLLRLAPTLRKKAHNYQERGMNLGELDIIAFAALKREVLDLNSHFPPPTEYLRQGWRSLSLVGPTFARVLFAHPDAPEFLRSNLGRSILFDVGISL.....
Q88Q68_PSEPK/2-209                 ..............DDSDYLRLLTIQAEQANAFLSNARKWERERWVCQRLLQGLNIPYRSEDFTPAGQE.PPDVLFRDAAFEVFFVLDEGRRLNDEWREELQRRRSAFSLAQLVRREARPRRISATELLGRLAPTLRKKAHNYRERGLELNELDIIAFSSLKREVLDLNTHFPPPTEYLRQGWRSLSLVGPTFARVLFAHPDAPDFLRGNLGRSIVFDVGISL.....
A0A077F3I4_9PSED/2-209             ..............DDSDYLRLLTIQAEQANAFLSNARKWERERWVCQRLLQGLNIPYRSEDFTPAGQE.PPDVLFRDAAFEVFFVLDEGRRLNDEWREELQRRRSAFSLSQLVRREARPRRISAQELLQRLAPTLRKKSHNYQERGLDLSELDIIAFASLKREVLDLNSHFPPPTEYLRQGWRSLSLVGPTFARVLFAHPDAPDFLRGNLGRSIVFDVGISL.....
C3KE89_PSEFS/2-209                 ..............DDSDYLRLLTVAAEQANAFLSNARKWERERWVCQRLLQGLNVPYRAEEFHAAGQE.PPDVLFRDASFEVFFVLDEGRRLNDEWRDELLRRRSAFSLSQLVRREAKPRRIPAHEFLLRLAPTLRKKAHNYKERGMDLGELDIVAFTSLKREVLDLNSHFPPPTEYLRQGWRSLSLVGPTFARVLFAHPDAPDFLRNNLGRSIVFDVGISL.....
S6ARN7_PSERE/2-208                 ..............NESDYLRLLTRQAEQANDFLSNARKWERERWVCQRLLQALNLPSRLDDF-STGQE.PPDVQFREANFEVFFVLDEGRRLNEEWRAELERRRSAFSLAQLVRRESRPKRIPAAELQARLAPTLRKKAHNYRERGLDLGELDLLAFVNLKRATPDFNSPFPPPTEYLLQGWRSLTLLGPNFARVLFAHNDAPDFLRSNLGRTILFDVGIGL.....
Q888U6_PSESM/2-209                 ..............DDSDYLRLLTIQAEQANAFLSNARKWERERWVCQRLLQGLNIAHRNEDFTPASQE.PPDVLFRDGRFEVFFVLDEGRRLNDEWREELARRRSAFSLSQLVRREAKPKRIPASELLHRLAPTLRKKSTNYRERGIDLSGLDIIAFASLKREVLDLNSHFPPPTEYLRQGWRSLSLVGPTFARVLFAHPGAPDFLRTNLGRSVVFDVGISL.....
G8QCT6_PSEFL/2-208                 ..............DDSDYLRLLTIAAEQANAFLSNARKWERERWVCQRLLQGLNVPYRADEF-APAGE.PPDVLFRDANFEVFFVLDEGRRLNDEWRDELQRRRSAFSLSQLVRREAKPRRIPANEFLMRLAPTLRKKAHNYTERGMDLGDLDIIAFASLKREVLDLNSHFPPPTEYLRQGWRSLSLVGPTFARVLFAHPDAPDFLRSNLGRSIVFDVGISL.....
A0A024HN75_PSEKB/2-209             ..............NETDYLYLLRRQAELANDFLSNARKWERECWICQRLLQTLQVDYHQDEFVEPEQQ.PPDVLFRDACFEVFLVLDEGRRLNEEWRDELQRRRLAQSLRQLIRREQKPQRINCSELQRRLAPTLRKKAQNYGERGIDPGELDLLAFVSLKRDTPDFNTPFPPPTEYLRQGWRSLSLVGPNFARVIFANRNAPEFLRDNLGRVILLDNGVGI.....
I4N134_9PSED/2-209                 ..............DDSDYLRLLTIQAEQANAFLSNARKWERERWVCQRLLQGLNIPYRNEEFNPANQE.PPDVLFREASFEVFFVLDEGRRLNDEWREELQRRRSAFSLAQLVRREARPKRIGAPELLQRLAPTLRKKSHNYKERGLDLGELDIIAFASLKREVLDLNSHFPPPTEYLRQGWRSLSLVGPTFARVLFAHPDAPDFLRSNLGRSIVFDVGISL.....
M4WS05_PSEDE/2-209                 ..............NESDYLRLLTRQAEQANDLLSNARKWERECWACQRLLQALKVPYRQEDFIEPTQQ.PPDVLFRDASFEVFFVLDQGRRLNEEWREELLRRRMAQSLNQLIRREQRPRRIPCADLQARLAPTLRKKAHNYSERGIDLSDLDLLAFVSLKRETADFNTPFPPPTEYLRQGWRSLSIVGPTFARVLFAHTDAPDFLRGSLGRTVLFDMGMGL.....
A0A077LBE3_9PSED/2-209             ..............DDSDYLRLLTSQAEQANAFLSNARKWERERWVCQRLLQGLNIPYRHEDFLPAEQE.PPDVLFFDARFEVFFVLDEGRRLNDEWREELQRRRSAFSLSQLVRRETKPKRVPAPALLRRLAPTLLKKASNYQERGLDLGALDIIAFASLKREALDLNSHFPPPTEYLRQGWRSLSLVGPNFARVLFAHPGAPDFLRTNLGRTVVFDVGISL.....
M1P9G0_DESSD/2-201                 ...........eeh---EILQNIKDAAQDALYFYSNRGKEERERWVVKELLKFLGIPHENSEIISHEQNsKTDVEFRKCSFQIKEIPDPCILRSKYYKDQYNAIKSARKLEDIELPATVAQDTPEITRMYDLVLLESQKLSESDVYLTTKNELDLVFYVTRTRASLVSNEEIN-AKDFVNLGWRSISCLNAKQAVVLFASKKAPAFFKTN-------------erqif
G8QKI8_DECSP/9-206                 dkgfledcrnalre---------------SVEYFSAKKKPERERWVCHEFIQNLGLTYGEQEVATPSDE.PPDVVFRDCRFEIKELLDPGRRRHQDYKASLQKALEATDPQDLL-KEFSPKDITPQQIGDRIHNALETLQKHYAPS--SRRHLDILFYVNLQEHFLKV-GPMPSPHFFAPYGWRSVSAIIDRGALVFFAGPDAPRALVSSVGKLVL-------rk...
A0A0K1QGL0_PSEFL/2-208             ..............DDSDYLRLLTIAAEQANAFLSNARKWERERWVCQRLLQGLNIPYRVDEF-APAGE.PPDVLFRDANFEVFFVLDEGRRLNDEWRDELQRRRSAFSLSSLVRREAKPRRIPANEFLLRLAPTLRKKAHNYKERGMDLGELDIIAFASLKREVLDLNSHFPPPTEYLRQGWRSLSLVGPTFARVLFAHPDAPDFLRSNLGRSIVFDVGISL.....
A0A089WM00_9PSED/2-209             ..............DDSDYLRLLTIQAEQANAFLSNARKWERERWVCQRLLQGLNVPYRNEDFTPAGQE.PPDVLFGDAAFEVFFVLDEGRRLNDEWREELQRRRSAFSLSQLVRREARPRRISAQELLGRLAPTLRKKAHNYVERGLDLNELDIIAFTSLKREVLDLNSHFPPPTEYLRQGWRSLSLVGPTFARVLFAHPDAPDFLRSNLGRSIVFDVGISL.....
D7HVN8_PSESS/2-209                 ..............DDSDYLRLLTIQAEQANAFLSNARKWERERWVCQRLLQGLNIAHRNEDFTPATEE.PPDVLFRDGRFEVFFVLDEGRRLNDEWREELARRRSAFSLSQLVRREAKPKRIPASELLHRLAPTLRKKSTNYRERGIDLGGLDIIAFASLKREVLDLNSHFPPPTEYLRQGWRSLSLVGPTFARVLFAHPGAPDFLRTNLGRSVVFDVGISL.....
A0A089YSX3_9PSED/2-209             ..............DDSDYLRLLTSQAEQANAFLSNARKWERERWVCERLLQGLNITYRDDEFTPAGQE.PPDVLFREASFEVFFVLDEGRRLNDEWREELQRRRSAFSLSQLVRREARPKRIRAPELLQRLAPTLRKKAHNYRERGLDLGELDIIAFASLKRETLDLNSHFPPPTEFLRQGWRSLSLVGPTFARVLFAHPDAPDFLRNNLGRSIVFDVGISL.....
Q9HVP2_PSEAE/2-209                 ..............NEADYLRLLTRQAEQANDFLSNARKWDRERWVCQRFLEALNVPYRQEDFAAPGEQ.PPDVLFKGAGFEVFFVLDEGRRLNEEWREELTRRRQAVSLRQLIRREERPQRIAAAELQARLAPTLRKKAHNYSERGIDHGELDLLAFVNLKRAVPDFNTPFPPPTEYLRQGWRSLSMVGPTFARVLFAHSGAPEFLRANLGRSILFDAGVGL.....
#=GR Q9HVP2_PSEAE/2-209      SS    ..............-HHHHHHHHHHHHHHHHHHHHHS-HHHHHHHHHHHHHHHTT----GGGEE--SSS.S-SEEETTEEEEEEEEE---------------------------------EEEEHHHHHHTTHHHHHHHHHHHHHHT--GGG-EEEEEEE-SSEEEETTS-----HHHHHTT-SEEEEE-SSEEEEEEE-TTS-HHHHTTTT--EE--TTT--.....
W0HF32_PSECI/2-209                 ..............DDSDYLRLLTSQAEQANAFLSNARKWERERWVCERLLQGLNIPHRHEDFLPAGQE.PPDVLFRDACFEVFFVLDEGRRLNDEWREELERRRSAFSLSQLVRREAKPKRIPASELLRRLAPTLSKKASNYRERGLNLGELDIIAFASLKREVLDLNSHFPPPTEYLRQGWRSLSLVGPTFARVLFAHPDAPDFLRTNLGRSVVFDVGISL.....
A0A0N0E222_9PSED/2-209             ..............DDSDFLRLLTIQAEQANTFLSNARKWERERWVCQRLLQGLNVPYRNEDFHPAGQE.PPDVLFRDARFEVFFVLDEGRRLNDEWREELQRRRSAFSLSQLVRREAKPRRIPASELLLRLAPTLRKKSHNYKERGLDLSELDIIAFASLKREVLDLNSHFPPPTEYLRQGWRSLSLVGPTFARVLFAHPDAPDFLRGNLGRSIVFDVGISL.....
A4XQC0_PSEMY/2-209                 ..............DDSDYLRLLTHQAEQANAFLSNAKKWERERWVCQRLLQALNVRHQTEDFTPGAQE.PPDVLFRDANFEVFFVLDEGRRLNDEWRAELERRRSAFSLSQLVRREARPKRIPASELQARLAPTLRKKAHNYRERGLDLSELDLIAFVSLKRAVLDCNSHFPPPTEYLRQGWRSLSLVGPRFARVLFAHPDAPDFLRQNLGRSLLFDIGIGL.....
#=GC SS_cons                       ..............-HHHHHHHHHHHHHHHHHHHHHS-HHHHHHHHHHHHHHHTT----GGGEE--SSS.S-SEEETTEEEEEEEEE---------------------------------EEEEHHHHHHTTHHHHHHHHHHHHHHT--GGG-EEEEEEE-SSEEEETTS-----HHHHHTT-SEEEEE-SSEEEEEEE-TTS-HHHHTTTT--EE--TTT--.....
#=GC seq_cons                      ..............DDSDYLRLLThQAEQANAFLSNARKWERERWVCQRLLQGLNlPYRsE-FtsuuQE.PPDVLFRDAsFEVFFVLDEGRRLNDEWR-ELpRRRSAFSLSQLVRREA+P+RIPAsELLtRLAPTLRKKAHNYpERGlDLuELDIIAFsSLKREVLDLNSHFPPPTEYLRQGWRSLSLVGPTFARVLFAHPDAPDFLRsNLGRSIVFDVGISL.....
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