GenomeNet

Database: Pfam
Entry: DUF1925
LinkDB: DUF1925
Original site: DUF1925 
#=GF ID   DUF1925
#=GF AC   PF09094.10
#=GF DE   Domain of unknown function (DUF1925)
#=GF AU   Sammut SJ
#=GF SE   pdb_1k1x
#=GF GA   21.10 21.10;
#=GF TC   21.20 22.60;
#=GF NC   21.00 20.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   12618437
#=GF RT   Crystal structures of 4-alpha-glucanotransferase from
#=GF RT   Thermococcus litoralis and its complex with an inhibitor. 
#=GF RA   Imamura H, Fushinobu S, Yamamoto M, Kumasaka T, Jeon BS, Wakagi
#=GF RA   T, Matsuzawa H; 
#=GF RL   J Biol Chem. 2003;278:19378-19386.
#=GF DR   INTERPRO; IPR015178;
#=GF DR   SCOP; 1k1x; fa;
#=GF CC   Members of this family, which are found in a set of prokaryotic
#=GF CC   transferases, adopt an immunoglobulin/albumin-binding
#=GF CC   domain-like fold, with a bundle of three alpha-helices. Their
#=GF CC   function is, as yet, unknown [1].
#=GF SQ   117
#=GS S6AM04_9PROT/312-391      AC S6AM04.1
#=GS A0A0A0DPA7_9SPIO/314-394  AC A0A0A0DPA7.1
#=GS I0IRH9_LEPFC/326-407      AC I0IRH9.1
#=GS A0A0T6AFX4_9BACT/320-403  AC A0A0T6AFX4.1
#=GS A0A0D2GG25_9DELT/315-391  AC A0A0D2GG25.1
#=GS A0A060UPT2_9PROT/313-392  AC A0A060UPT2.1
#=GS B4U8M8_HYDS0/292-367      AC B4U8M8.1
#=GS A0A0C2ZNT2_9PROT/321-376  AC A0A0C2ZNT2.1
#=GS E8QZ00_ISOPI/316-400      AC E8QZ00.1
#=GS D5U1B5_THEAM/279-355      AC D5U1B5.1
#=GS A0A0S7WIK1_9BACT/317-403  AC A0A0S7WIK1.1
#=GS I2K7Y2_9PROT/312-387      AC I2K7Y2.1
#=GS B3DYE7_METI4/314-392      AC B3DYE7.1
#=GS A0A0S3QUK1_9AQUI/305-378  AC A0A0S3QUK1.1
#=GS J9ZG14_LEPFM/317-392      AC J9ZG14.1
#=GS E1QE88_DESB2/313-388      AC E1QE88.1
#=GS AMYA_PYRFU/312-385        AC P49067.2
#=GS C6A1M6_THESM/311-384      AC C6A1M6.1
#=GS Q47IJ1_DECAR/312-389      AC Q47IJ1.1
#=GS A0A0S8DUK7_9BACT/1-32     AC A0A0S8DUK7.1
#=GS B8D3J6_DESK1/284-361      AC B8D3J6.1
#=GS A0A0C5JL98_9RHOO/310-389  AC A0A0C5JL98.1
#=GS C6HZA5_9BACT/318-398      AC C6HZA5.1
#=GS A6Q9R7_SULNB/310-383      AC A6Q9R7.1
#=GS F8GJH9_NITSI/316-395      AC F8GJH9.1
#=GS F8ACG7_THEID/311-386      AC F8ACG7.1
#=GS A0A0S8IT62_9BACT/313-397  AC A0A0S8IT62.1
#=GS W0SIZ3_9RHOO/310-389      AC W0SIZ3.1
#=GS F8F2N4_TRECH/270-347      AC F8F2N4.1
#=GS A0A142Y4D5_9PLAN/314-397  AC A0A142Y4D5.1
#=GS E6W2E9_DESIS/322-394      AC E6W2E9.1
#=GS A0A136N384_9BACT/314-394  AC A0A136N384.1
#=GS Q0AGI7_NITEC/332-395      AC Q0AGI7.1
#=GS A0A0C2ZH04_9HELI/310-385  AC A0A0C2ZH04.1
#=GS Q7UWA6_RHOBA/314-397      AC Q7UWA6.1
#=GS A0A0G3WHX4_9BACT/313-394  AC A0A0G3WHX4.1
#=GS B5YA08_COPPD/304-384      AC B5YA08.1
#=GS F9ZT22_ACICS/309-388      AC F9ZT22.1
#=GS A0A0S8J408_9BACT/313-402  AC A0A0S8J408.1
#=GS A0A0T5ZHZ1_9CHLR/313-392  AC A0A0T5ZHZ1.1
#=GS R5LI48_9SPIR/313-399      AC R5LI48.1
#=GS A6Q3J2_NITSB/301-369      AC A6Q3J2.1
#=GS A0A163UTW2_9BACT/306-381  AC A0A163UTW2.1
#=GS W0JH97_DESAE/305-379      AC W0JH97.1
#=GS M5R797_9PLAN/314-397      AC M5R797.1
#=GS A0A0S7XS49_9BACT/267-356  AC A0A0S7XS49.1
#=GS A0A149W0A9_9PROT/313-392  AC A0A149W0A9.1
#=GS A0A135VDC0_9ARCH/308-386  AC A0A135VDC0.1
#=GS B3QX98_CHLT3/315-396      AC B3QX98.1
#=GS A0A0F7K8W4_9PROT/333-396  AC A0A0F7K8W4.1
#=GS D5MLP9_9BACT/323-399      AC D5MLP9.1
#=GS A0A0S8GZX5_9BACT/313-394  AC A0A0S8GZX5.1
#=GS E4TFH8_CALNY/310-385      AC E4TFH8.1
#=GS M5TS05_9PLAN/314-397      AC M5TS05.1
#=GS V2Q2K2_9BACT/310-386      AC V2Q2K2.1
#=GS U2KNK6_TRELE/290-369      AC U2KNK6.1
#=GS E6X3H1_NITSE/303-375      AC E6X3H1.1
#=GS A0A178AMT9_9PLEO/195-247  AC A0A178AMT9.1
#=GS A0A075M0A3_9EURY/311-384  AC A0A075M0A3.1
#=GS C5A2X3_THEGJ/312-385      AC C5A2X3.1
#=GS Q82T86_NITEU/332-395      AC Q82T86.1
#=GS A0A142WRY2_9PLAN/314-398  AC A0A142WRY2.1
#=GS M5SZ05_9PLAN/314-397      AC M5SZ05.1
#=GS A0A0S8K851_9BACT/314-397  AC A0A0S8K851.1
#=GS C0GEN2_9FIRM/288-367      AC C0GEN2.1
#=GS A0A0F7CL61_9CREN/278-354  AC A0A0F7CL61.1
#=GS A0A091AKS4_9HELI/304-379  AC A0A091AKS4.1
#=GS A3DPC3_STAMF/280-357      AC A3DPC3.1
#=GS H9UHZ7_SPIAZ/289-369      AC H9UHZ7.1
#=GS C6XD94_METGS/313-392      AC C6XD94.1
#=GS A0A0S7WSJ0_9BACT/314-400  AC A0A0S7WSJ0.1
#=GS A0A0S8J6M8_9BACT/314-400  AC A0A0S8J6M8.1
#=GS V5WGF6_9SPIO/288-368      AC V5WGF6.1
#=GS A3ZYX6_9PLAN/320-404      AC A3ZYX6.1
#=GS A0A098QS88_9SPIO/302-382  AC A0A098QS88.1
#=GS MALQ_THELN/311-384        AC O32462.1
#=GS MALQ_THELN/311-384        DR PDB; 1K1X B; 311-384;
#=GS MALQ_THELN/311-384        DR PDB; 1K1W A; 311-384;
#=GS MALQ_THELN/311-384        DR PDB; 1K1Y A; 311-384;
#=GS MALQ_THELN/311-384        DR PDB; 1K1X A; 311-384;
#=GS MALQ_THELN/311-384        DR PDB; 1K1Y B; 311-384;
#=GS B6YUX8_THEON/309-382      AC B6YUX8.1
#=GS Q1H1J9_METFK/317-396      AC Q1H1J9.1
#=GS B8E149_DICTD/314-393      AC B8E149.1
#=GS L0DPN2_SINAD/314-398      AC L0DPN2.1
#=GS G0GFD9_SPITZ/284-364      AC G0GFD9.1
#=GS A0A0S8E2U2_9BACT/285-360  AC A0A0S8E2U2.1
#=GS C1DV50_SULAA/310-386      AC C1DV50.1
#=GS D5SYM1_PLAL2/314-400      AC D5SYM1.1
#=GS A0A0F8VWR0_9ARCH/326-419  AC A0A0F8VWR0.1
#=GS A0A0F0CUM9_9BACT/312-395  AC A0A0F0CUM9.1
#=GS A0A0T6AB87_9DELT/320-399  AC A0A0T6AB87.1
#=GS D6TNV7_9CHLR/321-398      AC D6TNV7.1
#=GS M1YXJ0_NITG3/314-394      AC M1YXJ0.1
#=GS A0A0Q1AQE1_9DELT/317-391  AC A0A0Q1AQE1.1
#=GS F2LVZ3_HIPMA/299-372      AC F2LVZ3.1
#=GS H1XYW1_9BACT/313-395      AC H1XYW1.1
#=GS MALQ_THEKO/311-384        AC O32450.1
#=GS E8T250_THEA1/303-376      AC E8T250.1
#=GS D4H3F1_DENA2/311-386      AC D4H3F1.1
#=GS S3JZP9_TREMA/290-369      AC S3JZP9.1
#=GS A1RYB3_THEPD/234-310      AC A1RYB3.1
#=GS F5YM35_TREPZ/269-348      AC F5YM35.1
#=GS F0SLA9_RUBBR/314-399      AC F0SLA9.1
#=GS A0A0R2XG72_9BACT/308-387  AC A0A0R2XG72.1
#=GS A0A0S8HI64_9DELT/205-291  AC A0A0S8HI64.1
#=GS D2QX36_PIRSD/315-398      AC D2QX36.1
#=GS B7J933_ACIF2/313-392      AC B7J933.1
#=GS F9ZJ13_9PROT/334-395      AC F9ZJ13.1
#=GS F0LL12_THEBM/309-382      AC F0LL12.1
#=GS E1R6M3_SPISS/309-389      AC E1R6M3.1
#=GS C0R0I6_BRAHW/313-394      AC C0R0I6.1
#=GS F2NMK1_MARHT/283-360      AC F2NMK1.1
#=GS AMYA_PYRAB/311-384        AC Q9V298.1
#=GS B2V9J4_SULSY/309-385      AC B2V9J4.1
#=GS A0A142YLC1_9PLAN/314-398  AC A0A142YLC1.1
#=GS F8AFR2_PYRYC/311-383      AC F8AFR2.1
#=GS E0UP59_SULAO/303-377      AC E0UP59.1
#=GS A0A162HH58_9DELT/314-396  AC A0A162HH58.1
#=GS A6BZU9_9PLAN/314-400      AC A6BZU9.1
#=GS I3TFI2_THEC1/278-355      AC I3TFI2.1
#=GS A0A0S8GIV0_9BACT/304-376  AC A0A0S8GIV0.1
S6AM04_9PROT/312-391                 ..........GMWKNFLTRYPEANWMHKRMLGLSERLDKL....PS.......NR..KK...PA............MLDALYRAQANDAYWH.G.LFG.GLYLPHLRRAVYHAIVELE---gsl......
A0A0A0DPA7_9SPIO/314-394             ........as--YREFLAKYRESGLLYAKMMYVNVLSNQL...kGD.......KY..RK...KN............AKEELWRGQEHHAYWH.G.PNG.GICNSRLRHSTYSTLIEAEKA-t........
I0IRH9_LEPFC/326-407                 ..........GIFEQFLTKYPDSRRLYHRMLLAEQLFSSR....VA.......KDdpDR...DR............VGHPLWVSQGNDVYWH.G.LFG.GLYLSNLRHTAFNGIISMENL-l........
A0A0T6AFX4_9BACT/320-403             ..........GFWRNFLVKYPEVNDLHWAMLRLSRALHDAlarrPR.......DP..RL...LE............ARRHLWRGQGNDAYWH.G.IFG.GCYLPHLRRGARQALLEAERV-l........
A0A0D2GG25_9DELT/315-391             ..........GIWDNFLVKYRESNLMHKRMLFVSQKLANM....--.......-D..AP...EL............ALDHLYQSQCNCAYWH.G.LFG.GLYLAHLRAAVHEHLIKADTL-a........
A0A060UPT2_9PROT/313-392             ..........GIWKNFLTRYPESNWMHKRMLRLSQRFHAL....PK.......RQ..QS...KT............MRADLHEAQANDAYWH.G.LFG.GIYLPHLRRAVFNAIVRLEAQ-l........
B4U8M8_HYDS0/292-367                 ..........GIWKNFFTKYQESNYMHKRMLEVSKK----....SS.......KK..RK...SS............KKDYILKAQCNDAYWH.G.IFG.GIYFPHLRREVWNNIIKADFE-n........
A0A0C2ZNT2_9PROT/321-376             rslelskeri------------------------------....--.......--..KG...KK............YKKALFKTQCNDVLWH.G.VFG.GIYLPNLRDNAYRYIIECENL-k........
E8QZ00_ISOPI/316-400                 ..........GFWRNFRVKYPEADEMIARMMAVSNRLAQL....ES.......RP..DA...DPdy.......leaARLDLYRGQCNCPYWH.G.AFG.GLYLPHLRNAIYEHLIAADL--al.......
D5U1B5_THEAM/279-355                 ..........GFFRNFLTRYRESNNMHKKILYVRSKLLKV....--.......-E..AP...RE............VMLKYYLAQCNDAFWH.G.LFG.GIYLTHLRQAIYENLIKVEKY-a........
A0A0S7WIK1_9BACT/317-403             ..........GFWRNFLAKYPESNNMHKKMLWVGEKSNRI....AK.......ET..LS...IEeqe.....llieIEREKYRGQCNCAYWH.G.VFG.GLYLPHLRGAIYKHLINAERL-i........
I2K7Y2_9PROT/312-387                 ..........GIWKNFFVKYEESNRIHKRMMELAKVRQEV....--.......--..KK...SD............FDTALYKAQTNDALWH.G.VFG.GLYLPNLRDNAYHYIIEAEN--ir.......
B3DYE7_METI4/314-392                 ..........GNWLSFLSKYPEANYIHKRMLQVSEKIRSL....-P.......GN..LR...ED............IYDSLLASQGHTVYWH.A.YKD.GLFGNYIRDNAFYHILSTEK--ki.......
A0A0S3QUK1_9AQUI/305-378             ..........GIWKNFFVKYPESNYMHKRMLDLTSYSC--....--.......--..RK...KA............FLEELSKAQCNDAFWH.G.IFG.GLYLPNLRDNFWRFLISANE--ia.......
J9ZG14_LEPFM/317-392                 ..........GIFENFLVKYPDVARMYGRMLQVSDMVKSG....--.......--..ES...PE............ALEALMRAQGNDVYWH.G.LFG.GIYLSNLRHEAYSNLLKAEDA-l........
E1QE88_DESB2/313-388                 ..........GVWDNFLVKYRPSNIMHKRMLRISQKVAQS....--.......--..GD...PI............ARDHLYQAQCNCAYWH.G.MFG.GLYLGHLRQAVHQQLIAAEA--ic.......
AMYA_PYRFU/312-385                   ..........GIWKNFFYKYPESNYMHKRMLMVSKLVRNN....--.......--..--...PE............ARKYLLRAQCNDAYWH.G.LFG.GVYLPHLRRAIWNNLIKANSY-v........
C6A1M6_THESM/311-384                 ..........GIWKNFFFKYPESNFMHKRMLMISKAVREN....--.......--..--...PE............ARHYILKAQCNDAYWH.G.VFG.GVYLPHLRRTVWENIIKAQSY-l........
Q47IJ1_DECAR/312-389                 ..........GIWRNFLTRYPEANWMHKRMQGLSARLGEI....--.......AN..PP...QA............LVDELYRAQANDAYWH.G.LFG.GLYLPHLRRAVWNNIIALEAE-l........
A0A0S8DUK7_9BACT/1-32                ..........------------------------------....--.......--..--...--............----------NCGYWH.G.IFG.GLYLNHLRSAVYSNLIEAEKA-l........
B8D3J6_DESK1/284-361                 ..........GFFRNFLVKYKEADNMHKKMLWVKKKLEKA....--.......GD..LP...RE............LRVEYLLAQCNDAYWH.G.LFG.GVYLAHLRQAIYEKLLKVER--wa.......
A0A0C5JL98_9RHOO/310-389             ..........GIWRNFMSRYPEANWMHKRMLDISQRLARL....PA.......AQ..RT...AG............MQEHLHRAQANDAYWH.G.LFG.GLYLPHLRRAVWHNLLALEAA-l........
C6HZA5_9BACT/318-398                 ..........GIFENFLVKYPDVHRLYHRMLLTGHFIAEA...yPG.......TT..PP...DA............VLLPYLRAQGNDVYWH.G.LFG.GLYLSNLRHEAYRSLLESERA-l........
A6Q9R7_SULNB/310-383                 ........as--WKNFFVKYEESNRLHKRMIEVSKHQTD-....--.......--..-N...KK............YLDALYRLQTNDVFWH.G.IFG.GLYLPNLRDNAYAYLCECEN--lr.......
F8GJH9_NITSI/316-395                 ..........GIWKNFFSRYPESNWMHKRMLGLSARLNAL....PE.......KH..RT...DL............MQQKLYESQANDAYWH.G.LFG.GLYLPHLRRAVYGALVELEAL-l........
F8ACG7_THEID/311-386                 ..........GHWRNFFVKYPESNHLHKRMLQVSELSRRK....--.......--..ID...PE............ARLDLLASQCNDAYWH.G.IFG.GLYLPHLRQAVWQKLLSAEG--kl.......
A0A0S8IT62_9BACT/313-397             ..........GFWRNFLAKYPEANNMHKKMLKLSQKISEI....EN.......QK..RR...SKtk.......lnkAKDLLWKGQCNCPYWH.G.VFG.GLYLPHLRSAVYQNLIQAEKL-v........
W0SIZ3_9RHOO/310-389                 ..........GIWRNFMSRYTEANWMHKRMLGASRRLAGL....PA.......EQ..RT...SD............LQEFLHRAQANDAYWH.G.LFG.GLYLPHLRRAIWNNLLQLEAA-l........
F8F2N4_TRECH/270-347                 .......rqs------LVKYPEANDIYGKMIYVHTLVNQL...rGD.......KA..RK...KN............AREELWKAQGIDMFYM.D.SSR.GIQNRMLRKAVYKSLLEAERI-t........
A0A142Y4D5_9PLAN/314-397             ..........GFWRNFRVKYSEANEMYCRMLDVSRKLEFA...rRS.......NQ..DKgllSE............AEDHLYRAQCNCPYWH.G.AFG.GIYLPHLRNATYKELIAADNI-l........
E6W2E9_DESIS/322-394                 .........s-IWKNFLVKYPESNNIHKKMLRLASLPLG-....--.......--..--...LE............AREALYQGQCNDVMWH.G.VFG.GLYLPNLRFNAYEALNRCERL-a........
A0A136N384_9BACT/314-394             ..........GFWRSFFVKYRETQQMHRKMLSVSEKVHQI....PD......lSD..IK...AE............ALRHLWAGQCNCGYWH.G.IFG.GIYLNHIRAENYHNLIEAEKY-a........
Q0AGI7_NITEC/332-395                 ..........----------------HKRMLGLSARYASL....PA.......RQ..RT...SA............MQRCLYASQANDAYWH.G.LFG.GLYLPHLRRTVYNNLIELEAQ-l........
A0A0C2ZH04_9HELI/310-385             ..........GVWKNFLVKYSESNRIHKRMLELSHARLG-....--.......-V..NK...PA............FDEALYKLQTNDALWH.G.VFG.GLYLPNLRDNAYAFLIEAET--ir.......
Q7UWA6_RHOBA/314-397                 ..........GFWRNFKVKYEETNEMYARMMHVSDRLAKA...eAS.......GH..DA...GEl.........seIRDHLYRGQCNCPYWH.G.AFG.GIYLPHLRNAIYEHLIQADTL-l........
A0A0G3WHX4_9BACT/313-394             ..........GFWRNFLTKYEEANNMHKKMLRVSDKVGKYv..lSK.......KP..LA...QK............ALDNLYAGQCNCAYWH.G.VFG.GLYLPHLRKAVYASLLKAENL-y........
B5YA08_COPPD/304-384                 ..........GFWRRFLKSHPESRWMYGRVVSLSRYLNNL....AP.......RH.pRK...NK............ALMELYRAEANDVFWH.G.VFG.GLYLSHLRRNLYHRLIRA----itta.....
F9ZT22_ACICS/309-388                 ..........GIWKNFLSRYPEGNWMHKRMLQLSARFHAL....PR.......RR..QS...PV............MRAALHAAQANDAYWH.G.LFG.GIYLPHLRRAVYHALLTLESA-l........
A0A0S8J408_9BACT/313-402             ..........GLWRNFLAKYPEANNMHKKMLRISEKIRNT....KS.......TQ..KG...KIkkane..lvlsqAKDELWKGQCNCSYWH.G.VFG.GLYLPHLRSAIYKHLIGAEKV-v........
A0A0T5ZHZ1_9CHLR/313-392             ..........GFWRNFQARYREIDDLHKQMLRTSSKVADM....AD.......GP..TK...AR............AIDHLQRGQSNDCYWH.G.LFG.GIYLVHMRLATLSHLIAAEDL-a........
R5LI48_9SPIR/313-399                 ..........GFWRNYFSKYSESNRMNKRMIYASNIFDRF....KF.......KR..NK...DKike.....dkeiALDYLLQGQCNCPYWH.G.TFG.GLYLNNLRHATYSNLIKST---sis......
A6Q3J2_NITSB/301-369                 ..........GIWRNFFVKYEESNRLHKRMLDLSKKQK--....--.......--..--...--............-SEYLYKLQTNDVFWH.G.IFG.GLYLPNLRDNAYRFVAECEK--sl.......
A0A163UTW2_9BACT/306-381             ..........GFWRNFLTRYAEANDLHKRVLHAEKAVRDS....--.......--..GS...RE............ALRHLWRSQCNCSYWH.G.VFG.GIYLPHLRDAVWVELAEAERT-a........
W0JH97_DESAE/305-379                 ..........GTWRNFLAKYDEANNMHKRVLFAKQFLDSK....--.......--..-N...KQ............KTEQFFDAQCNDAYWH.G.IFG.GLYMPHLRNAVYENIISAA---nfe......
M5R797_9PLAN/314-397                 ..........GFWRNFKTKYDETNEMYARMMHVSRQLAEI...eATg....igAS..EI...SQ............IRDDLYRGQCNCPYWH.G.AFG.GIYLPHLRNAVFQHLIAADNE-l........
A0A0S7XS49_9BACT/267-356             ..........GDFRQALMKYPEANHMHKKMLLVSNRLQTL....SRgkalfggER..KR...EEl.........qkAKLELYKGQCGCAYGQ.G.VSG.GIYLNYLRHAVYSHLIRSEI--el.......
A0A149W0A9_9PROT/313-392             ..........GIWRNFMMRYPEANHLHKRMLGLSTRFHAL....PA.......LQ..QT...AE............RRRLLYETQANDAYWH.G.LFG.GLYLPHLRRALYRALLQLE---gdl......
A0A135VDC0_9ARCH/308-386             ..........GYFRNFLAKYPEANRAHKKMIYVSRKVHKM....-R.......EK..GK...AR............AKRELWRGQENCVYWH.Q.DSG.GIYLPDLRDTVYAHLISAEV--ia.......
B3QX98_CHLT3/315-396                 ..........GFWRNFMVKYPESNQMHKRMLEISTRARDLq..eKG.......KK..VK...PE............TIDKIWEAQCNCPYWH.G.VFG.GTYLPNLRHPIFTALIEADV--al.......
A0A0F7K8W4_9PROT/333-396             ..........----------------HKRMLSLSARFAAL....PV.......TQ..CS...DA............MRQKLYAAQANDAYWH.G.LFG.GLYLPHLRRAIYNNVVELESL-l........
D5MLP9_9BACT/323-399                 ..........GHWKHFLVRYPEANRAHKKGLALSRLLPGG....--.......-H..GA...TQ............ARLELFAAQCNDSYWH.G.IFG.GLYLPHLRHEIWRHLARAEA--fi.......
A0A0S8GZX5_9BACT/313-394             ..........GLWRNFLAKYPEANNMHKKMLQISEKIRNVk..sPK.......KD..EI...EK............AKDELWKGQCNCPFWH.G.VFG.GLYLPHLRSAIYKHLIEAEKI-i........
E4TFH8_CALNY/310-385                 .........a-HWKNFFVKYPESNHIHKRILKISEKAKEL....--.......--..KN...DY............LDDLLFRAECNDVLWH.G.IFG.GIYLPNLRDNAFRYIIKAEKE-i........
M5TS05_9PLAN/314-397                 ..........GFWRNFKTKYEETNEMYARMMHVSERLKKA...eEA.......GL..DAgvlAE............ARDHLYRGQCNCPYWH.G.AFG.GIYLPHLRNAIYEHLIAADTI-l........
V2Q2K2_9BACT/310-386                 .........s-VWKNFLVKYPESNRLHKRTVDLSIRGRKY....--.......-K..NN...SE............FKDLLYRSQCNDSLWH.G.VFG.GLYLPNLRNNAWAPLIQAEAM-y........
U2KNK6_TRELE/290-369                 ........tv---KDFLTVYPESNRLYSRMMYVSMLINQC...rGD.......KA..RK...KA............AKEELWAAQNFAAYIY.T.GKG.GISDKVLRGKTYRHLLQAEKL-a........
E6X3H1_NITSE/303-375                 ..........GIWKNFFVKYEESNRLHKRMLQMNRLLLPE....--.......--..--...-E............NREDLYRLQCNDVYWH.G.VFG.GLYLPNLRDNAYRYLARCEKL-l........
A0A178AMT9_9PLEO/195-247             ........ia------------------RQMQVAQRNQAL....QA.......QR..QA...AE............SRESLYQAQASIAQHH.G.VFGsG---------------------lqtppmsrs
A0A075M0A3_9EURY/311-384             ..........GIWKNFFFKYPESNFMHKRMLYVSRLAREH....--.......--..--...EE............ARNYILKAQCNDAYWH.G.VFG.GVYLPHLRRAIWENIIKAQSY-f........
C5A2X3_THEGJ/312-385                 ..........GIWKNFFFKYPESNYMHKRMLMVSKLVRDN....--.......--..--...PE............ARRFLLRAQCNDAYWH.G.VFG.GIYLPHLRRAVWENIIRANS--fv.......
Q82T86_NITEU/332-395                 ..........----------------HKRMLGLSARYARL....PA.......SQ..RT...DA............MQQCLYASQANDAYWH.G.LFG.GLYLPHLRRAVYNNLIELEAL-l........
A0A142WRY2_9PLAN/314-398             ..........GFWRNFLVKYPESNEMYCRMREVSDRIARA....GT.......DG..TA...RPdl.......laqAQTELFRGQCNCPYWH.G.AFG.GLYLPHLRNAIYRHLIAADTL-l........
M5SZ05_9PLAN/314-397                 ..........GFWRNFKTKYEETNEMYARMMYVSDRLAKA...eEA.......GL..DAgvlAE............ARDHLYRGQCNCPYWH.G.AFG.GIYLPHLRNAIYEHLIAADTI-l........
A0A0S8K851_9BACT/314-397             ..........GFWRNFLAKYPESNNMHKKMLAVSQKVGLL....TE.......EK..GA...SVlv........rrAQDELFQGQCNDAYWH.G.VFG.GLYLNHLRSAIYGHLLEAEKI-a........
C0GEN2_9FIRM/288-367                 ..........GFWRNFFVRYPESNQIHKKMLHVRDKLSRV....PA.......GP..QK...SE............AEEYLWAGQCNCAYWH.G.VFG.GLYLNFLRSALYSRLIAAETL-t........
A0A0F7CL61_9CREN/278-354             ..........GYFPNFLRKYPEANNMHKKLLRVREKLVRL....--.......-K..AP...PH............AWENYYLAQCNDAYWH.G.LFG.GTYLPILRQAIYEHLIKAER--is.......
A0A091AKS4_9HELI/304-379             ..........GIWKNFLVKYPEANHIHKRMLRLSKHIGAI....--.......--..RD...ET............YREWVYKAQTNDVFWH.G.VFG.GIYLPNLRDNAYRYIIEAQS--il.......
A3DPC3_STAMF/280-357                 ..........GFFRNFLIKYRESNNMHKKMLWVRRKLKNA....--.......PE..VA...EE............AWRYYHLAQCNDAYWH.G.LFG.GIYLSHLRQAIYEYYLKAERL-a........
H9UHZ7_SPIAZ/289-369                 ..........GFFRNFLIRYPEVSRLYAKMQYTHILVNQI...rGD.......KQ..RK...QA............AREELWRGQHHSAYWH.G.RSA.GVYNRTTRSELYRSLIQAEKM-a........
C6XD94_METGS/313-392                 ..........GIWRNFFMRYPESNWMHKRMLALSERFNQL....PD.......NK..KT...AD............MRQALYESQANDAYWH.G.LFG.GLYLPHLRRAVYNAMLKLESL-l........
A0A0S7WSJ0_9BACT/314-400             ..........GFWRSFRAKYPEANEMYSKMMLVSEKVSRLgespVS.......GQ..T-...-Ngr.......yeaARDELYQGQCNCSYWH.G.IFG.GLYLPHLRYAVYNHLIAAENI-a........
A0A0S8J6M8_9BACT/314-400             ..........GFWRSFRAKYPEANEMYSKMMLVSEKVSRLgespVS.......GQ..T-...-Ngr.......yeaARDELYQGQCNCSYWH.G.IFG.GLYLPHLRYAVYNHLIAAENI-a........
V5WGF6_9SPIO/288-368                 .........s-IFRQNLGRYSEVNLMYAKMQFVQSLTAQI...rGD.......KY..RK...QA............AREELWHGQTHMPLWH.G.ERG.GVYFNNYRKEIYSSLIRSE---lmt......
A3ZYX6_9PLAN/320-404                 ..........GYWRNFKVRYPETDEMYSRMMAVSQRLDAA....RR.......QS..DV...DQaq.......ldlAQTELYRGQCNCSYWH.G.AFG.GVYLPHLRNAVYTALIAADNL-i........
A0A098QS88_9SPIO/302-382             ..........GMFRQALARYQEGNLLYGKMQFIHSLVNQV...rGD.......RY..RK...QA............AKEELWKGQSNVPFWF.G.PSG.GIYNPSYRKPSYAALISAEL--lt.......
MALQ_THELN/311-384                   ..........GIWKNFFFKYPESNFMHKRMLMVSKAVRDN....--.......--..--...PE............ARKYILKAQCNDAYWH.G.VFG.GIYLPHLRRTVWENIIKAQRY-l........
#=GR MALQ_THELN/311-384        SS    ..........--GGGHHHH-HHHHHHHHHHHHHHHHHTT-....--.......--..--...HH............HHHHHHHTTBGGGG--.S.SS-.GGG-HHHHHHHHHHHHHHHTT-S........
B6YUX8_THEON/309-382                 ..........GIWKNFFFKYPESNYMHKRMLMVSGLVRDN....--.......--..--...PE............ARHFILKAQCNDAYWH.G.IFG.GVYLPHLRRTIWENIIKANSY-v........
Q1H1J9_METFK/317-396                 ..........GIWRNFLMRYPESNWMHKRMLGLSQRYHSL....PP.......DL..QN...AQ............MLKALYEAQANDAYWH.G.LFG.GLYLPHLRRAVYHALIKLEAL-l........
B8E149_DICTD/314-393                 ..........GFWRNFLAKYDESNHMQKKMLYVWSKVQNY....PD.......GE..IK...DK............AEEEVFQGQANDAYWH.G.IFG.GLYLPHLRTAIYEHLIKAENY-i........
L0DPN2_SINAD/314-398                 ..........GYWRNFKARYSESDEMYARMLELSRRVALA...eAN.......PA..VD...PDyl........daARQDLYRGQCNCPYWH.G.AFG.GLYLPHLRNAIYRSLIASH---nal......
G0GFD9_SPITZ/284-364                 ....yvrqev-------SRIEEPHLLYAKMQYVQSLVRQL...rGD.......RS..RK...KT............AREDLYRGQTGAAYSIvS.GDG.GVACPWLRHAAYRALIQAEK--nt.......
A0A0S8E2U2_9BACT/285-360             ..........GYFKNFLVKYPEANNMQKKMLYVSERVAAT....--.......--..DS...KK............ALHHLYKGQCNCAYWH.G.IFG.GLYLNHLRSAVYSNLIEAEKA-m........
C1DV50_SULAA/310-386                 .........n-IWHNFLVKYPESNRIHKRVLDLSTTGRPY....--.......-K..KN...KE............FLENLLKSQCNDVLWH.G.IFG.GLYLPNLRNNTYKYIIKADKE-l........
D5SYM1_PLAL2/314-400                 ..........GFWRNFLVKYPETNEMYTRMLGVSQRLAEYe.elYG.......DK..EH...VAdl........raARADLYRAQCNCPYWH.G.AFG.GLYLPHLRNAVYSHLIAADHK-l........
A0A0F8VWR0_9ARCH/326-419             ..........GFWRSFLVKYPESNNMHKKMLYVRNKLMYTe..eTL.......IK..VE...DEnlisvilskineAWDEIYKSQCNDCYWH.G.MFG.GIYLQFLRFSVYTHLINAEKI-i........
A0A0F0CUM9_9BACT/312-395             ..........GFWRNFLTKYPESNHMNKKMIYVSKKIEALnnihVR.......QD..KL...SE............IKRYLFRGQCNCAYWH.G.VFG.GLYLFHLRSAIYHNLIKSEAY-i........
A0A0T6AB87_9DELT/320-399             ..........GHFRGFLRKYEEANQLHKRMLWVSGRVQEA....AE.......LG..GG...AE............ARDFLYRAQCNDVYWH.G.IFG.GIYLNHLREATYANLLRAEEA-s........
D6TNV7_9CHLR/321-398                 ..........GFWRNFLVRYPEINNQHKKMQHIHHKVYKA....--.......GA..TD...EH............GLHHLWKAQANDTYWH.G.LFG.GIYMTHVRSAIYHHLIKAENA-a........
M1YXJ0_NITG3/314-394                 ..........GQWDNFLTKYEESNLMHKKMLYVSRKVHRL....TP.......DQ..QK...ES...........gALRELYRGQCNCAQWH.G.LFG.GLYLNYLRHALYNHLIAAENI-a........
A0A0Q1AQE1_9DELT/317-391             ..........GYWRNYFSKYPESNYMSKRVNFLSSDLMKI....--.......--..-D...QS............ASVHILKAQCNCGYWH.G.IFG.GIYLPHLREAIFSNLLNAEQE-y........
F2LVZ3_HIPMA/299-372                 ..........GLWKNFFVKYEESNRLHKRMLELSKH--RL....--.......--..YS...RV............YLDNLYRLQTNDVFWH.G.IFG.GLYLPNLRDNAYRYLINCENL-r........
H1XYW1_9BACT/313-395                 ..........GFWRNFMSKYPEVNVMHKKMLRISQMVHQQn.feSA.......DK..EK...NR............ALDHLWAAQCNCPYWH.G.VFG.GLYLSHLRFAIFNNLIEAEKI-l........
MALQ_THEKO/311-384                   ..........GIWKNFFFKYPESNYMHKRMLMVSKAVRNN....--.......--..--...PE............AREFILRAQCNDAYWH.G.VFG.GVYLPHLRRAVWENIIKAQS--hv.......
E8T250_THEA1/303-376                 ..........GIWKSFFVKYPESNYMHKRMLKLCSLG---....--.......-V..KS...GR............FTENLLKSQCNDVFWH.G.VFG.GIYLPVLRDNFWRYTVEATK--ea.......
D4H3F1_DENA2/311-386                 ..........GIWKNFLVKYPESNRIHKRTVSLSKKANES....--.......--..GD...LQ............LLDALYKAQCNDVLWH.G.IFG.GLYLPNLRNNAYRFIIEAEKR-l........
S3JZP9_TREMA/290-369                 ........tv---KDFFTVYPEAHRLYSRMMYVSMLINQC...rGD.......KV..RK...KA............AKEQLYAAQNFAPYMY.T.GSG.GVSDKALRSKTYRRLITAEKL-v........
A1RYB3_THEPD/234-310                 ..........GYFPNFLRKYRETNNMHKKMLYVRGKLSLL....--.......-K..AS...RE............AWEEYLKAQCNDAYWH.G.LFG.GVYIPFLRQAVFEHLVRAERL-a........
F5YM35_TREPZ/269-348                 .........e---RKFLIAFPEANGIYVKMIFTHSQINQL...rGD.......KS..RK...QS............AREELWKAQGYSLFCD.AdTHG.GIRRSSFRKAAYKSILAAEK--ic.......
F0SLA9_RUBBR/314-399                 ..........GFWRNFLVKYPESHEMYCRMREISDRLQELr..kDP.......EL..AA...TAmf........rsAEDHLYRGQCNCPYWH.G.AFG.GLYLPHLRNAIYYHLITADSL-i........
A0A0R2XG72_9BACT/308-387             ..........GSWGSFRVRYEELNLIYRKNLMLGRKLKGK....SQ.......FP..GA...RA............VTERLWRAQCSTAQWH.G.TQG.GLHSPHLRGAIWRELLSAEAE-m........
A0A0S8HI64_9DELT/205-291             ..........GIWENFLVKYPEANQLHKKMLRVSQKVHRA....MQ.......SRfiST...KEfp.......pppALQALWRGQDSCAYWH.G.LFG.GLHLNYLRHATYQNLIGAERL-a........
D2QX36_PIRSD/315-398                 ..........GFWRNFKVKYPETNEMYARMMMASKRVAQAerdgVT.......GD..TF...RH............ARQALYRGQCNCPYWH.G.AFG.GIYLPHLRNAIFNQLIACDNL-l........
B7J933_ACIF2/313-392                 ..........GIWKNFLTRYPESNWMHKRMLQLSRRFHAL....PG.......RQ..QS...KT............LRADLHEAQANDAYWH.G.LFG.GIYLPHLRRAVFNAIVRLEA--gl.......
F9ZJ13_9PROT/334-395                 ..........------------------RMLGLSARLAEL....PA.......QQ..RT...SE............MQQKLYESQANDAYWH.G.MFG.GLYLPHLRRAVYNAMVELEAL-l........
F0LL12_THEBM/309-382                 ..........GIWKNFFYKYPESNFMHKRMLYVSKLVRNI....--.......--..--...PE............ARRYILKAQCNDAYWH.G.VFG.GVYLPHLRRAVWENIIRAQSY-v........
E1R6M3_SPISS/309-389                 ..........GYFRQFLTRYPESNLLYARMMYTYLLVNQV...qRD.......RA..RK...KS............AREESWRGQCNAPYWH.G.RYN.GVYDNHLRKAAYRSFITAEKT-t........
C0R0I6_BRAHW/313-394                 ..........GFWRNYFSKYSESNRMNKRMIFTSNMIGEIt..eSN.......YK..EK...EE............ALSYLLKGQCNCPYWH.G.TFG.GLYLNNLRHATYANLIKATS--is.......
F2NMK1_MARHT/283-360                 ........ap--FHNFLSRYPQALDLWAKMRYVSEKVEET....--.......KR..PP...EE............AYRALYRAQAADAFWP.A.ASG.GVYRPEIRIAAWRALIEAEN--ac.......
AMYA_PYRAB/311-384                   ..........GIWKNFFYKYPEANYMHKRMLMLSRLLRDN....--.......--..--...PS............ARRFVLRAQCNDAYWH.G.VFG.GIYLPHLRRAIWSNLIKAHS--hl.......
B2V9J4_SULSY/309-385                 .........n-IWHNFLVKYPESNRIHKRFLDLSISYRDY....--.......-K..KN...QT............FLDNLLKSQCNDVLWH.G.IFG.GLYLPNLRNNAYRFIIKAEKE-i........
A0A142YLC1_9PLAN/314-398             ..........GFWRNFKARYPESDEMYARMLGLSKRLAAL....AA.......RP..DV...DPdy.......leaARRELHRGQCNCPYWH.G.AFG.GLYLPHLRGAIYQALIACH---dal......
F8AFR2_PYRYC/311-383                 ..........GIWKNFFFKYPEGNYMHKRMLMISKLARDK....--.......--..--...PE............ARRFILRAQCNDAYWH.G.VFG.GIYLPHLRRAIWENIIRAH---vp.......
E0UP59_SULAO/303-377                 ..........GIWKNFFIKYHESNYLHKRMLYLSLQQKDF....--.......--..-D...KY............SLDALYRLQTNDAFWH.G.VFG.GFYLPSLRDNAYKYLLEIQQ--qr.......
A0A162HH58_9DELT/314-396             ..........GTWRNFLAKYPEANWIHKRMLMVSRELKAR....AA.......GK..KD...GSq.........akGERHLYQAQCNDAYWH.G.VFG.GLYLPHLRTAVYENLILAEN--ia.......
A6BZU9_9PLAN/314-400                 ..........GFWRNFRVKYAELNEMYTRMLHVSNRLQSL...eET.......GV..DA...EDlpa......lheARTELYRAQCNCPYWH.G.AFG.GLYLPHLRNAIYKHLISADTL-l........
I3TFI2_THEC1/278-355                 ..........GFFRNFIVKYAEVNNMHKKMLWVRRKLERA....--.......GG..GL...EE............AWRSYLLAQCNDAYWH.G.LFG.GVYLSHLRQAIYENYIKAERA-a........
A0A0S8GIV0_9BACT/304-376             ..........GYFRNFLSKYPEANIMHKRMLHVSKSLRNS....--.......--..--...ES............AKRSLWRGQCSCAYWH.G.IFG.GLYLPHLRDAIYRNLIDAEQ--p........
#=GC SS_cons                         ..........--GGGHHHH-HHHHHHHHHHHHHHHHHTT-....--.......--..--...HH............HHHHHHHTTBGGGG--.S.SS-.GGG-HHHHHHHHHHHHHHHTT-S........
#=GC seq_cons                        ..........GhW+NFhsKYPEuNthHKRMLhlSpclpph.................tt...pp............upcpLa+uQCNssYWH.G.lFG.GlYLPHLRpAlYppLIpAEp..h........
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