GenomeNet

Database: Pfam
Entry: DUF1925
LinkDB: DUF1925
Original site: DUF1925 
#=GF ID   DUF1925
#=GF AC   PF09094.9
#=GF DE   Domain of unknown function (DUF1925)
#=GF AU   Sammut SJ
#=GF SE   pdb_1k1x
#=GF GA   21.10 21.10;
#=GF TC   21.20 26.70;
#=GF NC   21.00 20.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   12618437
#=GF RT   Crystal structures of 4-alpha-glucanotransferase from
#=GF RT   Thermococcus litoralis and its complex with an inhibitor. 
#=GF RA   Imamura H, Fushinobu S, Yamamoto M, Kumasaka T, Jeon BS, Wakagi
#=GF RA   T, Matsuzawa H; 
#=GF RL   J Biol Chem. 2003;278:19378-19386.
#=GF DR   INTERPRO; IPR015178;
#=GF DR   SCOP; 1k1x; fa;
#=GF CC   Members of this family, which are found in a set of prokaryotic
#=GF CC   transferases, adopt an immunoglobulin/albumin-binding
#=GF CC   domain-like fold, with a bundle of three alpha-helices. Their
#=GF CC   function is, as yet, unknown [1].
#=GF SQ   69
#=GS S6AM04_9PROT/312-391      AC S6AM04.1
#=GS I0IRH9_LEPFC/326-407      AC I0IRH9.1
#=GS B4U8M8_HYDS0/292-367      AC B4U8M8.1
#=GS E8QZ00_ISOPI/316-400      AC E8QZ00.1
#=GS D5U1B5_THEAM/279-355      AC D5U1B5.1
#=GS I2K7Y2_9PROT/312-387      AC I2K7Y2.1
#=GS B3DYE7_METI4/314-392      AC B3DYE7.1
#=GS J9ZG14_LEPFM/317-392      AC J9ZG14.1
#=GS E1QE88_DESB2/313-388      AC E1QE88.1
#=GS AMYA_PYRFU/312-385        AC P49067.2
#=GS E4TXL9_SULKY/311-386      AC E4TXL9.1
#=GS Q47IJ1_DECAR/312-389      AC Q47IJ1.1
#=GS B8D3J6_DESK1/284-361      AC B8D3J6.1
#=GS C6HZA5_9BACT/318-398      AC C6HZA5.1
#=GS A6Q9R7_SULNB/310-383      AC A6Q9R7.1
#=GS F8GJH9_NITSI/316-395      AC F8GJH9.1
#=GS F8ACG7_THEID/311-386      AC F8ACG7.1
#=GS W0SIZ3_9RHOO/310-389      AC W0SIZ3.1
#=GS F8F2N4_TRECH/270-347      AC F8F2N4.1
#=GS E6W2E9_DESIS/322-394      AC E6W2E9.1
#=GS Q7UWA6_RHOBA/314-397      AC Q7UWA6.1
#=GS A0A0G3WHX4_9BACT/313-394  AC A0A0G3WHX4.1
#=GS B5YA08_COPPD/304-384      AC B5YA08.1
#=GS F9ZT22_ACICS/309-388      AC F9ZT22.1
#=GS R5LI48_9SPIR/313-399      AC R5LI48.1
#=GS A6Q3J2_NITSB/301-369      AC A6Q3J2.1
#=GS W0JH97_DESAE/305-379      AC W0JH97.1
#=GS B3QX98_CHLT3/315-396      AC B3QX98.1
#=GS A0A0F7K8W4_9PROT/333-396  AC A0A0F7K8W4.1
#=GS D5MLP9_9BACT/323-399      AC D5MLP9.1
#=GS E4TFH8_CALNY/310-385      AC E4TFH8.1
#=GS E6X3H1_NITSE/303-375      AC E6X3H1.1
#=GS Q82T86_NITEU/332-395      AC Q82T86.1
#=GS C5A2X3_THEGJ/312-385      AC C5A2X3.1
#=GS C0GEN2_9FIRM/288-367      AC C0GEN2.1
#=GS A3DPC3_STAMF/280-357      AC A3DPC3.1
#=GS C6XD94_METGS/313-392      AC C6XD94.1
#=GS H9UHZ7_SPIAZ/289-369      AC H9UHZ7.1
#=GS V5WGF6_9SPIO/288-368      AC V5WGF6.1
#=GS A3ZYX6_9PLAN/320-404      AC A3ZYX6.1
#=GS MALQ_THELN/311-384        AC O32462.1
#=GS MALQ_THELN/311-384        DR PDB; 1K1X B; 311-384;
#=GS MALQ_THELN/311-384        DR PDB; 1K1W A; 311-384;
#=GS MALQ_THELN/311-384        DR PDB; 1K1Y A; 311-384;
#=GS MALQ_THELN/311-384        DR PDB; 1K1X A; 311-384;
#=GS MALQ_THELN/311-384        DR PDB; 1K1Y B; 311-384;
#=GS Q1H1J9_METFK/317-396      AC Q1H1J9.1
#=GS B8E149_DICTD/314-393      AC B8E149.1
#=GS G0GFD9_SPITZ/284-364      AC G0GFD9.1
#=GS L0DPN2_SINAD/314-398      AC L0DPN2.1
#=GS C1DV50_SULAA/310-386      AC C1DV50.1
#=GS D5SYM1_PLAL2/314-400      AC D5SYM1.1
#=GS A0A0F8VWR0_9ARCH/326-419  AC A0A0F8VWR0.1
#=GS A0A0F0CUM9_9BACT/312-395  AC A0A0F0CUM9.1
#=GS D6TNV7_9CHLR/321-398      AC D6TNV7.1
#=GS H1XYW1_9BACT/313-395      AC H1XYW1.1
#=GS MALQ_THEKO/311-384        AC O32450.1
#=GS F2LVZ3_HIPMA/299-372      AC F2LVZ3.1
#=GS D4H3F1_DENA2/311-386      AC D4H3F1.1
#=GS A1RYB3_THEPD/234-310      AC A1RYB3.1
#=GS F5YM35_TREPZ/269-348      AC F5YM35.1
#=GS F0SLA9_RUBBR/314-399      AC F0SLA9.1
#=GS B7J933_ACIF2/313-392      AC B7J933.1
#=GS D2QX36_PIRSD/315-398      AC D2QX36.1
#=GS C0R0I6_BRAHW/313-394      AC C0R0I6.1
#=GS E1R6M3_SPISS/309-389      AC E1R6M3.1
#=GS F0LL12_THEBM/309-382      AC F0LL12.1
#=GS F2NMK1_MARHT/283-360      AC F2NMK1.1
#=GS S5ZED6_9CREN/279-355      AC S5ZED6.1
#=GS B2V9J4_SULSY/309-385      AC B2V9J4.1
#=GS AMYA_PYRAB/311-384        AC Q9V298.1
#=GS A6BZU9_9PLAN/314-400      AC A6BZU9.1
#=GS E0UP59_SULAO/303-377      AC E0UP59.1
#=GS I3TFI2_THEC1/278-355      AC I3TFI2.1
S6AM04_9PROT/312-391                 ......GMWKNFLTRYPEANWMHKRMLGLSERLDKL....PSNR..KKPA............MLDALYRAQANDAYWH.G.LFGGLYLPHLRRAVYHAIVELE---gsl.
I0IRH9_LEPFC/326-407                 ......GIFEQFLTKYPDSRRLYHRMLLAEQLFSSR....VAKDdpDRDR............VGHPLWVSQGNDVYWH.G.LFGGLYLSNLRHTAFNGIISMENL-l...
B4U8M8_HYDS0/292-367                 ......GIWKNFFTKYQESNYMHKRMLEVSKK----....SSKK..RKSS............KKDYILKAQCNDAYWH.G.IFGGIYFPHLRREVWNNIIKADFE-n...
E8QZ00_ISOPI/316-400                 ......GFWRNFRVKYPEADEMIARMMAVSNRLAQL....ESRP..DADPdy.......leaARLDLYRGQCNCPYWH.G.AFGGLYLPHLRNAIYEHLIAADL--al..
D5U1B5_THEAM/279-355                 ......GFFRNFLTRYRESNNMHKKILYVRSKLLKV....---E..APRE............VMLKYYLAQCNDAFWH.G.LFGGIYLTHLRQAIYENLIKVEKY-a...
I2K7Y2_9PROT/312-387                 ......GIWKNFFVKYEESNRIHKRMMELAKVRQEV....----..KKSD............FDTALYKAQTNDALWH.G.VFGGLYLPNLRDNAYHYIIEAEN--ir..
B3DYE7_METI4/314-392                 ......GNWLSFLSKYPEANYIHKRMLQVSEKIRSL....-PGN..LRED............IYDSLLASQGHTVYWH.A.YKDGLFGNYIRDNAFYHILSTEK--ki..
J9ZG14_LEPFM/317-392                 ......GIFENFLVKYPDVARMYGRMLQVSDMVKSG....----..ESPE............ALEALMRAQGNDVYWH.G.LFGGIYLSNLRHEAYSNLLKAEDA-l...
E1QE88_DESB2/313-388                 ......GVWDNFLVKYRPSNIMHKRMLRISQKVAQS....----..GDPI............ARDHLYQAQCNCAYWH.G.MFGGLYLGHLRQAVHQQLIAAEA--ic..
AMYA_PYRFU/312-385                   ......GIWKNFFYKYPESNYMHKRMLMVSKLVRNN....----..--PE............ARKYLLRAQCNDAYWH.G.LFGGVYLPHLRRAIWNNLIKANSY-v...
E4TXL9_SULKY/311-386                 ......GIWKNFFVKYPESNRIHKRMLELSAQRPVI....----..NRSD............FDTALFKLQTNDPLWH.G.VFGGLYLPNLRDTAYRYLIECEN--ir..
Q47IJ1_DECAR/312-389                 ......GIWRNFLTRYPEANWMHKRMQGLSARLGEI....--AN..PPQA............LVDELYRAQANDAYWH.G.LFGGLYLPHLRRAVWNNIIALEAE-l...
B8D3J6_DESK1/284-361                 ......GFFRNFLVKYKEADNMHKKMLWVKKKLEKA....--GD..LPRE............LRVEYLLAQCNDAYWH.G.LFGGVYLAHLRQAIYEKLLKVER--wa..
C6HZA5_9BACT/318-398                 ......GIFENFLVKYPDVHRLYHRMLLTGHFIAEA...yPGTT..PPDA............VLLPYLRAQGNDVYWH.G.LFGGLYLSNLRHEAYRSLLESERA-l...
A6Q9R7_SULNB/310-383                 ....as--WKNFFVKYEESNRLHKRMIEVSKHQTD-....----..-NKK............YLDALYRLQTNDVFWH.G.IFGGLYLPNLRDNAYAYLCECEN--lr..
F8GJH9_NITSI/316-395                 ......GIWKNFFSRYPESNWMHKRMLGLSARLNAL....PEKH..RTDL............MQQKLYESQANDAYWH.G.LFGGLYLPHLRRAVYGALVELEAL-l...
F8ACG7_THEID/311-386                 ......GHWRNFFVKYPESNHLHKRMLQVSELSRRK....----..IDPE............ARLDLLASQCNDAYWH.G.IFGGLYLPHLRQAVWQKLLSAEG--kl..
W0SIZ3_9RHOO/310-389                 ......GIWRNFMSRYTEANWMHKRMLGASRRLAGL....PAEQ..RTSD............LQEFLHRAQANDAYWH.G.LFGGLYLPHLRRAIWNNLLQLEAA-l...
F8F2N4_TRECH/270-347                 ...rqs------LVKYPEANDIYGKMIYVHTLVNQL...rGDKA..RKKN............AREELWKAQGIDMFYM.D.SSRGIQNRMLRKAVYKSLLEAERI-t...
E6W2E9_DESIS/322-394                 .....s-IWKNFLVKYPESNNIHKKMLRLASLPLG-....----..--LE............AREALYQGQCNDVMWH.G.VFGGLYLPNLRFNAYEALNRCERL-a...
Q7UWA6_RHOBA/314-397                 ......GFWRNFKVKYEETNEMYARMMHVSDRLAKA...eASGH..DAGEl.........seIRDHLYRGQCNCPYWH.G.AFGGIYLPHLRNAIYEHLIQADTL-l...
A0A0G3WHX4_9BACT/313-394             ......GFWRNFLTKYEEANNMHKKMLRVSDKVGKYv..lSKKP..LAQK............ALDNLYAGQCNCAYWH.G.VFGGLYLPHLRKAVYASLLKAENL-y...
B5YA08_COPPD/304-384                 ......GFWRRFLKSHPESRWMYGRVVSLSRYLNNL....APRH.pRKNK............ALMELYRAEANDVFWH.G.VFGGLYLSHLRRNLYHRLIRA----itta
F9ZT22_ACICS/309-388                 ......GIWKNFLSRYPEGNWMHKRMLQLSARFHAL....PRRR..QSPV............MRAALHAAQANDAYWH.G.LFGGIYLPHLRRAVYHALLTLESA-l...
R5LI48_9SPIR/313-399                 ......GFWRNYFSKYSESNRMNKRMIYASNIFDRF....KFKR..NKDKike.....dkeiALDYLLQGQCNCPYWH.G.TFGGLYLNNLRHATYSNLIKST---sis.
A6Q3J2_NITSB/301-369                 ......GIWRNFFVKYEESNRLHKRMLDLSKKQK--....----..----............-SEYLYKLQTNDVFWH.G.IFGGLYLPNLRDNAYRFVAECEK--sl..
W0JH97_DESAE/305-379                 ......GTWRNFLAKYDEANNMHKRVLFAKQFLDSK....----..-NKQ............KTEQFFDAQCNDAYWH.G.IFGGLYMPHLRNAVYENIISAA---nfe.
B3QX98_CHLT3/315-396                 ......GFWRNFMVKYPESNQMHKRMLEISTRARDLq..eKGKK..VKPE............TIDKIWEAQCNCPYWH.G.VFGGTYLPNLRHPIFTALIEADV--al..
A0A0F7K8W4_9PROT/333-396             ......----------------HKRMLSLSARFAAL....PVTQ..CSDA............MRQKLYAAQANDAYWH.G.LFGGLYLPHLRRAIYNNVVELESL-l...
D5MLP9_9BACT/323-399                 ......GHWKHFLVRYPEANRAHKKGLALSRLLPGG....---H..GATQ............ARLELFAAQCNDSYWH.G.IFGGLYLPHLRHEIWRHLARAEA--fi..
E4TFH8_CALNY/310-385                 .....a-HWKNFFVKYPESNHIHKRILKISEKAKEL....----..KNDY............LDDLLFRAECNDVLWH.G.IFGGIYLPNLRDNAFRYIIKAEKE-i...
E6X3H1_NITSE/303-375                 ......GIWKNFFVKYEESNRLHKRMLQMNRLLLPE....----..---E............NREDLYRLQCNDVYWH.G.VFGGLYLPNLRDNAYRYLARCEKL-l...
Q82T86_NITEU/332-395                 ......----------------HKRMLGLSARYARL....PASQ..RTDA............MQQCLYASQANDAYWH.G.LFGGLYLPHLRRAVYNNLIELEAL-l...
C5A2X3_THEGJ/312-385                 ......GIWKNFFFKYPESNYMHKRMLMVSKLVRDN....----..--PE............ARRFLLRAQCNDAYWH.G.VFGGIYLPHLRRAVWENIIRANS--fv..
C0GEN2_9FIRM/288-367                 ......GFWRNFFVRYPESNQIHKKMLHVRDKLSRV....PAGP..QKSE............AEEYLWAGQCNCAYWH.G.VFGGLYLNFLRSALYSRLIAAETL-t...
A3DPC3_STAMF/280-357                 ......GFFRNFLIKYRESNNMHKKMLWVRRKLKNA....--PE..VAEE............AWRYYHLAQCNDAYWH.G.LFGGIYLSHLRQAIYEYYLKAERL-a...
C6XD94_METGS/313-392                 ......GIWRNFFMRYPESNWMHKRMLALSERFNQL....PDNK..KTAD............MRQALYESQANDAYWH.G.LFGGLYLPHLRRAVYNAMLKLESL-l...
H9UHZ7_SPIAZ/289-369                 ......GFFRNFLIRYPEVSRLYAKMQYTHILVNQI...rGDKQ..RKQA............AREELWRGQHHSAYWH.G.RSAGVYNRTTRSELYRSLIQAEKM-a...
V5WGF6_9SPIO/288-368                 .....s-IFRQNLGRYSEVNLMYAKMQFVQSLTAQI...rGDKY..RKQA............AREELWHGQTHMPLWH.G.ERGGVYFNNYRKEIYSSLIRSE---lmt.
A3ZYX6_9PLAN/320-404                 ......GYWRNFKVRYPETDEMYSRMMAVSQRLDAA....RRQS..DVDQaq.......ldlAQTELYRGQCNCSYWH.G.AFGGVYLPHLRNAVYTALIAADNL-i...
MALQ_THELN/311-384                   ......GIWKNFFFKYPESNFMHKRMLMVSKAVRDN....----..--PE............ARKYILKAQCNDAYWH.G.VFGGIYLPHLRRTVWENIIKAQRY-l...
#=GR MALQ_THELN/311-384        SS    ......--GGGHHHH-HHHHHHHHHHHHHHHHHTT-....----..--HH............HHHHHHHTTBGGGG--.S.SS-GGG-HHHHHHHHHHHHHHHTT-S...
Q1H1J9_METFK/317-396                 ......GIWRNFLMRYPESNWMHKRMLGLSQRYHSL....PPDL..QNAQ............MLKALYEAQANDAYWH.G.LFGGLYLPHLRRAVYHALIKLEAL-l...
B8E149_DICTD/314-393                 ......GFWRNFLAKYDESNHMQKKMLYVWSKVQNY....PDGE..IKDK............AEEEVFQGQANDAYWH.G.IFGGLYLPHLRTAIYEHLIKAENY-i...
G0GFD9_SPITZ/284-364                 yvrqev-------SRIEEPHLLYAKMQYVQSLVRQL...rGDRS..RKKT............AREDLYRGQTGAAYSIvS.GDGGVACPWLRHAAYRALIQAEK--nt..
L0DPN2_SINAD/314-398                 ......GYWRNFKARYSESDEMYARMLELSRRVALA...eANPA..VDPDyl........daARQDLYRGQCNCPYWH.G.AFGGLYLPHLRNAIYRSLIASH---nal.
C1DV50_SULAA/310-386                 .....n-IWHNFLVKYPESNRIHKRVLDLSTTGRPY....---K..KNKE............FLENLLKSQCNDVLWH.G.IFGGLYLPNLRNNTYKYIIKADKE-l...
D5SYM1_PLAL2/314-400                 ......GFWRNFLVKYPETNEMYTRMLGVSQRLAEYe.elYGDK..EHVAdl........raARADLYRAQCNCPYWH.G.AFGGLYLPHLRNAVYSHLIAADHK-l...
A0A0F8VWR0_9ARCH/326-419             ......GFWRSFLVKYPESNNMHKKMLYVRNKLMYTe..eTLIK..VEDEnlisvilskineAWDEIYKSQCNDCYWH.G.MFGGIYLQFLRFSVYTHLINAEKI-i...
A0A0F0CUM9_9BACT/312-395             ......GFWRNFLTKYPESNHMNKKMIYVSKKIEALnnihVRQD..KLSE............IKRYLFRGQCNCAYWH.G.VFGGLYLFHLRSAIYHNLIKSEAY-i...
D6TNV7_9CHLR/321-398                 ......GFWRNFLVRYPEINNQHKKMQHIHHKVYKA....--GA..TDEH............GLHHLWKAQANDTYWH.G.LFGGIYMTHVRSAIYHHLIKAENA-a...
H1XYW1_9BACT/313-395                 ......GFWRNFMSKYPEVNVMHKKMLRISQMVHQQn.feSADK..EKNR............ALDHLWAAQCNCPYWH.G.VFGGLYLSHLRFAIFNNLIEAEKI-l...
MALQ_THEKO/311-384                   ......GIWKNFFFKYPESNYMHKRMLMVSKAVRNN....----..--PE............AREFILRAQCNDAYWH.G.VFGGVYLPHLRRAVWENIIKAQS--hv..
F2LVZ3_HIPMA/299-372                 ......GLWKNFFVKYEESNRLHKRMLELSKH--RL....----..YSRV............YLDNLYRLQTNDVFWH.G.IFGGLYLPNLRDNAYRYLINCENL-r...
D4H3F1_DENA2/311-386                 ......GIWKNFLVKYPESNRIHKRTVSLSKKANES....----..GDLQ............LLDALYKAQCNDVLWH.G.IFGGLYLPNLRNNAYRFIIEAEKR-l...
A1RYB3_THEPD/234-310                 ......GYFPNFLRKYRETNNMHKKMLYVRGKLSLL....---K..ASRE............AWEEYLKAQCNDAYWH.G.LFGGVYIPFLRQAVFEHLVRAERL-a...
F5YM35_TREPZ/269-348                 .....e---RKFLIAFPEANGIYVKMIFTHSQINQL...rGDKS..RKQS............AREELWKAQGYSLFCD.AdTHGGIRRSSFRKAAYKSILAAEK--ic..
F0SLA9_RUBBR/314-399                 ......GFWRNFLVKYPESHEMYCRMREISDRLQELr..kDPEL..AATAmf........rsAEDHLYRGQCNCPYWH.G.AFGGLYLPHLRNAIYYHLITADSL-i...
B7J933_ACIF2/313-392                 ......GIWKNFLTRYPESNWMHKRMLQLSRRFHAL....PGRQ..QSKT............LRADLHEAQANDAYWH.G.LFGGIYLPHLRRAVFNAIVRLEA--gl..
D2QX36_PIRSD/315-398                 ......GFWRNFKVKYPETNEMYARMMMASKRVAQAerdgVTGD..TFRH............ARQALYRGQCNCPYWH.G.AFGGIYLPHLRNAIFNQLIACDNL-l...
C0R0I6_BRAHW/313-394                 ......GFWRNYFSKYSESNRMNKRMIFTSNMIGEIt..eSNYK..EKEE............ALSYLLKGQCNCPYWH.G.TFGGLYLNNLRHATYANLIKATS--is..
E1R6M3_SPISS/309-389                 ......GYFRQFLTRYPESNLLYARMMYTYLLVNQV...qRDRA..RKKS............AREESWRGQCNAPYWH.G.RYNGVYDNHLRKAAYRSFITAEKT-t...
F0LL12_THEBM/309-382                 ......GIWKNFFYKYPESNFMHKRMLYVSKLVRNI....----..--PE............ARRYILKAQCNDAYWH.G.VFGGVYLPHLRRAVWENIIRAQSY-v...
F2NMK1_MARHT/283-360                 ....ap--FHNFLSRYPQALDLWAKMRYVSEKVEET....--KR..PPEE............AYRALYRAQAADAFWP.A.ASGGVYRPEIRIAAWRALIEAEN--ac..
S5ZED6_9CREN/279-355                 ......GYFPNFLRKYREVNNMHKKMLYVREKLASL....---G..ASES............AWREYMLGQCNDAYWH.G.LFGGVYIPLLRQEVYSHLIRAERI-a...
B2V9J4_SULSY/309-385                 .....n-IWHNFLVKYPESNRIHKRFLDLSISYRDY....---K..KNQT............FLDNLLKSQCNDVLWH.G.IFGGLYLPNLRNNAYRFIIKAEKE-i...
AMYA_PYRAB/311-384                   ......GIWKNFFYKYPEANYMHKRMLMLSRLLRDN....----..--PS............ARRFVLRAQCNDAYWH.G.VFGGIYLPHLRRAIWSNLIKAHS--hl..
A6BZU9_9PLAN/314-400                 ......GFWRNFRVKYAELNEMYTRMLHVSNRLQSL...eETGV..DAEDlpa......lheARTELYRAQCNCPYWH.G.AFGGLYLPHLRNAIYKHLISADTL-l...
E0UP59_SULAO/303-377                 ......GIWKNFFIKYHESNYLHKRMLYLSLQQKDF....----..-DKY............SLDALYRLQTNDAFWH.G.VFGGFYLPSLRDNAYKYLLEIQQ--qr..
I3TFI2_THEC1/278-355                 ......GFFRNFIVKYAEVNNMHKKMLWVRRKLERA....--GG..GLEE............AWRSYLLAQCNDAYWH.G.LFGGVYLSHLRQAIYENYIKAERA-a...
#=GC SS_cons                         ......--GGGHHHH-HHHHHHHHHHHHHHHHHTT-....----..--HH............HHHHHHHTTBGGGG--.S.SS-GGG-HHHHHHHHHHHHHHHTT-S...
#=GC seq_cons                        ......GhW+NFhsKYPEoNpMHKRMLhlSpplpph.......t..tppp............spctLa+uQsNDsYWH.G.lFGGlYLPaLRpAlYppLIcAEp..h...
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