GenomeNet

Database: Pfam
Entry: DUF1938
LinkDB: DUF1938
Original site: DUF1938 
#=GF ID   DUF1938
#=GF AC   PF09153.9
#=GF DE   Domain of unknown function (DUF1938)
#=GF AU   Sammut SJ
#=GF SE   pdb_1mgt
#=GF GA   22.10 22.10;
#=GF TC   22.50 95.60;
#=GF NC   21.50 21.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   10497033
#=GF RT   Hyperthermostable protein structure maintained by intra and
#=GF RT   inter-helix ion-pairs in archaeal O6-methylguanine-DNA
#=GF RT   methyltransferase. 
#=GF RA   Hashimoto H, Inoue T, Nishioka M, Fujiwara S, Takagi M, Imanaka
#=GF RA   T, Kai Y; 
#=GF RL   J Mol Biol. 1999;292:707-716.
#=GF DR   INTERPRO; IPR015236;
#=GF DR   SCOP; 1mgt; fa;
#=GF CC   Members of this family, which are predominantly found in the
#=GF CC   archaeal protein O6-alkylguanine-DNA alkyltransferase, adopt a
#=GF CC   secondary structure consisting of a three stranded antiparallel
#=GF CC   beta-sheet and three alpha helices. Their exact function has
#=GF CC   not, as yet, been defined, though it has been postulated that
#=GF CC   they confer thermostability to the archaeal protein [1].
#=GF SQ   10
#=GS OGT_PYRFU/2-90         AC Q8TZV2.1
#=GS OGT_THEGJ/1-85         AC C5A3L5.1
#=GS F8AIH4_PYRYC/1-86      AC F8AIH4.1
#=GS B6YXZ4_THEON/1-86      AC B6YXZ4.1
#=GS OGT_THESM/1-86         AC C6A382.1
#=GS OGT_THEBM/1-86         AC F0LIT8.1
#=GS OGT_PYRAB/1-86         AC Q9V1N7.1
#=GS OGT_THEKO/1-85         AC O74023.1
#=GS OGT_THEKO/1-85         DR PDB; 1MGT A; 1-85;
#=GS H3ZKP7_THELN/1-86      AC H3ZKP7.1
#=GS A0A075LU92_9EURY/1-86  AC A0A075LU92.1
OGT_PYRFU/2-90                    ILEVRKFQVKNKAVYIGTLSEDKIFGIIFSIDEPEVIRHRIPTLINFLEKR-LNKKLEIKEgnSGFSDVVFKTLIGKISNEEAAEfiE--vs
OGT_THEGJ/1-85                    MLAVERFGVNGRDIWIGVIFHGRIQGISFAFTRGELLE-RIRNLAEFLRGRDVRVSLDVQP..SNYTELVYRVLIGELENEKALP..ELS..
F8AIH4_PYRYC/1-86                 MISIEAFSLANRKILIAVLWEEKIEGITFSLDGKEFLKERITRLREFLLRRGASISLRLET..SNYPELVFKILVGEVENREALK..ELS..
B6YXZ4_THEON/1-86                 MLSVERFDIARKEVWIAVIFDEKIQGITFSLDGEGFLRERIANMAFFLKKRGVNVELTLLE..SDYPRLVRDVILGKLENEELLP..EL-g.
OGT_THESM/1-86                    MISIKSFQIGEKEIVIAILFDKKIQGITFSFDGEQFLQERVNALVEHLTNRGVKVNLEERD..SELPALVYKILIGEIRNQDGLE..YLS..
OGT_THEBM/1-86                    MISIEKFEIFGREIWIAVFFEEKIDGVTFSLDGCEYLMERINSLKALLERRNVSVNLAEEK..SDYPKIVYNVLVGDIENQDALR..FLS..
OGT_PYRAB/1-86                    MLSCESFKIKGREIIICVIWEEGIQGIVYSLDGREFLEKQLSRLISMLNKRGVSLSLKERH..SKYPELVFNVLTGKISNEEGFE..ELS..
OGT_THEKO/1-85                    MLSVEKFRVGERVVWIGVIFSGRVQGIAFAFDRGTLMK-RIHDLAEHLGKRGVSISLDVQP..SDYPEKVFKVLIGELDNASFLR..ELS..
#=GR OGT_THEKO/1-85         SS    -EEEEEEEETTEEEEEEEEESSSEEEEEEESSHHHHHH-HHHHHHHHHHHTT------B--..-SHHHHHHHHHTTSS-GGGGGG..GB-..
H3ZKP7_THELN/1-86                 MIAIDSFKIGGREIQIAVIYEEKIQGIAFSLDGEEFLRERIRGLVKHLQKRGVNVDLREKE..SDFPQLVYRVLLGEIKNEEALE..YLS..
A0A075LU92_9EURY/1-86             MISVEQFKVENRSIWIGVIYGDKIQGVVYSLEGEGFLKERIEELTRFLRKRGADVRLEEEK..STYPQLVFDVLKGKLDNEEVLN..ILS..
#=GC SS_cons                      -EEEEEEEETTEEEEEEEEESSSEEEEEEESSHHHHHH-HHHHHHHHHHHTT------B--..-SHHHHHHHHHTTSS-GGGGGG..GB-..
#=GC seq_cons                     MlSlEpFclssR-IaIuVIa--KIQGIsFSLDGcEFL+ERIssLscaLpKRGVsVsLc.cc..ScYPcLVa+VLlG-l-NEEuLc..ELS..
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