#=GF ID DUF2016
#=GF AC PF09436.5
#=GF DE Domain of unknown function (DUF2016)
#=GF AU Mistry J
#=GF SE Iyer L
#=GF GA 19.80 19.80;
#=GF TC 20.00 22.90;
#=GF NC 19.10 19.30;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF WK Domain_of_unknown_function
#=GF RN [1]
#=GF RM 16859499
#=GF RT The prokaryotic antecedents of the ubiquitin-signaling system
#=GF RT and the early evolution of ubiquitin-like beta-grasp domains.
#=GF RA Iyer LM, Burroughs AM, Aravind L;
#=GF RL Genome Biol. 2006;7:R60.
#=GF DR INTERPRO; IPR018560;
#=GF CC A predicted alpha+beta domain that is usually fused N-terminal
#=GF CC to the JAB metallopeptidase. This protein in turn is found in
#=GF CC conserved gene neighborhoods that include genes encoding the
#=GF CC bacterial homologs of the ubiquitin modification system such as
#=GF CC the E1, E2 and Ub proteins [1]. The domain is also known as the
#=GF CC JAB-N domain.
#=GF SQ 40
#=GS B5S2X2_RALSL/53-126 AC B5S2X2.1
#=GS A1W6B4_ACISJ/8-79 AC A1W6B4.1
#=GS Q120V3_POLSJ/3-73 AC Q120V3.1
#=GS G2ZLL0_9RALS/53-126 AC G2ZLL0.1
#=GS F4G940_ALIDK/7-78 AC F4G940.1
#=GS G6EJV6_9SPHN/10-84 AC G6EJV6.1
#=GS D8NBM4_RALSL/53-126 AC D8NBM4.1
#=GS Q21Q53_RHOFD/9-78 AC Q21Q53.1
#=GS A0R7L0_PELPD/5-76 AC A0R7L0.1
#=GS Q5NUW4_RALME/1-71 AC Q5NUW4.1
#=GS Q7WX35_CUPNH/4-76 AC Q7WX35.1
#=GS Q11ZD2_POLSJ/1-71 AC Q11ZD2.1
#=GS C5T055_ACIDE/7-78 AC C5T055.1
#=GS A9ARU2_BURM1/4-76 AC A9ARU2.1
#=GS B3DAW9_BURM1/1-51 AC B3DAW9.1
#=GS A1VVA1_POLNA/3-75 AC A1VVA1.1
#=GS B1T0G3_9BURK/4-76 AC B1T0G3.1
#=GS D4Z234_SPHJU/10-81 AC D4Z234.1
#=GS F6AR87_DELSC/4-75 AC F6AR87.1
#=GS I0YG13_9BURK/9-81 AC I0YG13.1
#=GS D9SEQ3_GALCS/4-75 AC D9SEQ3.1
#=GS Q1L9T1_RALME/4-76 AC Q1L9T1.1
#=GS F8GZ26_CUPNN/4-76 AC F8GZ26.1
#=GS B1Z672_BURA4/4-76 AC B1Z672.1
#=GS A4JUM8_BURVG/4-76 AC A4JUM8.1
#=GS Q5NXB5_AROAE/4-75 AC Q5NXB5.1
#=GS B2UDC7_RALPJ/4-76 AC B2UDC7.1
#=GS C6BQW2_RALP1/4-76 AC C6BQW2.1
#=GS Q47D11_DECAR/5-75 AC Q47D11.1
#=GS F4GGG6_ALIDK/8-79 AC F4GGG6.1
#=GS D5WNV4_BURSC/4-76 AC D5WNV4.1
#=GS G2ZJ74_9RALS/53-126 AC G2ZJ74.1
#=GS A5VG87_SPHWW/8-81 AC A5VG87.1
#=GS Q8XYU8_RALSO/53-126 AC Q8XYU8.1
#=GS G3A6J3_9RALS/53-126 AC G3A6J3.1
#=GS C6BPY5_RALP1/4-76 AC C6BPY5.1
#=GS G4FY53_9GAMM/12-79 AC G4FY53.1
#=GS F2LSQ3_BURGS/4-76 AC F2LSQ3.1
#=GS E6QW91_9ZZZZ/4-75 AC E6QW91.1
#=GS F0B9Z3_9XANT/12-79 AC F0B9Z3.1
B5S2X2_RALSL/53-126 ........................LDAKLWDSAPTIAVPKFAE...FKQL..E..EVGHRFLATAEGLFVEVRRPWLHVIQPVApLNGQTVRPPYGTVKPKVELa......
A1W6B4_ACISJ/8-79 ........................RDQALLATCPVIAAPRFGT...LPDM..G..-NGQRIIVARNGWFVQTRLDWLDSIVALG.QGLPPMRLPYGEVAEHLRFs......
Q120V3_POLSJ/3-73 ........................LDSIIQGMFPTVIMPREGT...IAPA..T..KNGTRYVVAGDGLWREVVLPWVTVMHKIA.--NSDFMLPYGAAEEAVVIk......
G2ZLL0_9RALS/53-126 ........................LDAKLWDSAPTVAVPKFAE...FKQL..E..DVGHRFLATAEGLFVEVRRPWLHVIQPVApLNGQTVRPPYGTVKPKVDLa......
F4G940_ALIDK/7-78 ........................RDQALLAACPVIAAPRFGA...LPDM..G..-NGQRIIVARNGWFVQTRLDWLDSIVALG.HGSPSMRLPYGEVAEHLCFs......
G6EJV6_9SPHN/10-84 ......................aa---ALIAAAPCYPVPSTGRspaLDAL..RdgRAGHGLAVGKDGVMLILRRPWLALDAPLS.-PPFAAHIPYGSIGE----pkad...
D8NBM4_RALSL/53-126 ........................LDAKLWDSAPTVAVPKFAE...FKEL..E..KVGHRFLATAEGLFVEVRRPWLHVIQPVApLNGQTVRPPYGTVEPKVKLa......
Q21Q53_RHOFD/9-78 ........................IDRFLATDCPVITMPHDSE..vFEPL..K..TPGHRLIVAAGGLYKEIRRAWLHAIVHVA.----RAQTPFGELQTTLSMp......
A0R7L0_PELPD/5-76 ........................MDAILQEQFPTVMVPRYGD...FVPL..A..HNGRRFLSASDGLWLEEKNQWLHILWPLA.-LQNQVAMPYGSLQKKVDFl......
Q5NUW4_RALME/1-71 ........................--MALQQSFPSVMVPRHGA...LPAL..E..QVGERLLIAANGVFLEIVRPWLRVVRRLG.EFQHQTAIPYGDATEVTELr......
Q7WX35_CUPNH/4-76 .......................a-DAALQQSFPSVMVPRFGA...LAPM..E..RSGERLLIAANGVFLEIVRPWLSVVRHLG.AFQHRTAIPYGEAAETTDLr......
Q11ZD2_POLSJ/1-71 ........................MDAIIQSQFPTVLAPRFEA...LSPL..E..TTGDRFILTRHQVLMEVSRPWLHAIQAIS.-APFARQTPYGA-------gprlgik
C5T055_ACIDE/7-78 ........................RDQALLAACPVIAAPRFGA...LPDM..G..-NGQRVIVARNGWFVQTRLDWLDCIVALG.HGQPLMHLPYGEVAEHLRFs......
A9ARU2_BURM1/4-76 ........................VDTVLQQSFPSVMVPSREA...VVPM..T..RSGERLLITSDGVYLEVLRPWVRVVRRIA.HYAVSTAVPYGQVEETTAFs......
B3DAW9_BURM1/1-51 ........................-------------------...---M..T..RSGERLLITSDGVYLEVLRPWVRVVRRIA.HYAVSTAVPYGQVEETTAFs......
A1VVA1_POLNA/3-75 ........................LDQITMGVFPLLAASQTGV...LQDP..E..KHGVRYVAASDGMWRAIDTAWLKALTPVA.LSSKKAVIPYGRLTQSVEFl......
B1T0G3_9BURK/4-76 ........................LDTVLQQSFPSVMVPSREA...VVPM..A..RSGERLLIASDGVYLEISRPWVHVVRRIA.QYAVSTAVPYGNVEETTELl......
D4Z234_SPHJU/10-81 avlaavpchpvpplgkspaldalr-------------------...--S-..A..RSGHGLAVGSDGVMLILRRPWLALDVPVT.-PPIAAYLPYGSVG-----apka...
F6AR87_DELSC/4-75 ........................RDQALLAACPVVAAPRFGA...LPDM..A..-NGQRIIVARNGWFVQTRLDWLDSITALG.LEPPAMRLPYGEVREHLRFs......
I0YG13_9BURK/9-81 .......................a-DAALQRSFPTVMVPRREP...VAPM..Q..AAGERLLIGENGVFLEIDLRWLSVVRRIA.HYTVPTAIPYGKVAESTELr......
D9SEQ3_GALCS/4-75 ........................RDVALQSVMPTVMVPRYAE...LEEL..D..TPGNRILMAENGVWLEVCHAWLYARIPVS.-LPLRIPVPYGVIYEELRFg......
Q1L9T1_RALME/4-76 ........................ADMALQQSFPSVMVPRHGA...LPAL..E..QVGERLLIAANGVFLEIVRPWLRVVRRLG.EFQHQTAIPYGDATEVTELr......
F8GZ26_CUPNN/4-76 ........................MDITLQQSFPSVMVPRFGE...LAPL..E..ATGERLLIAANGVFLEVSRPWLRLVRRVG.QFDVKTAVPYGTAAEATDLr......
B1Z672_BURA4/4-76 ........................LDTVLQQSFPSVMVPSREP...VAPM..T..RSGERLLIASDGVYLEVLRPWVRVVRRIA.QYAVSTAVPYGKVDETTALl......
A4JUM8_BURVG/4-76 ........................LDTVLQQSFPAVMVPSRET...VVPM..T..RSGERLLIASDGVYLEVLRPWVRVVRRIA.QYAVSIAVPYGKVEETTALl......
Q5NXB5_AROAE/4-75 ........................RDMALQALTPTVMVPRFGC...FEPL..S..QPGHRFLVGQNGEWLEVRRAWMYARVQLT.-QPSPVVKPYGVVTACLEWl......
B2UDC7_RALPJ/4-76 ........................MDMTLQASFPTIMVPKFGS...LTPL..S..GSGERLLVGTNGVFLEVVRPWLRVVRKIA.SYEVETAVPYGTVNEETELp......
C6BQW2_RALP1/4-76 ........................MDMTLQASFPTIMVPKFGS...LTPL..S..GSGERLLVGTNGVFLEVVRPWLRVVRKIA.SYEVETAVPYGTVNEETELp......
Q47D11_DECAR/5-75 ........................RDLALQAVCPVIAAPRFGP...LPDM..A..-NGQRIILAANGVFVQVKLDWLDCIQRLS.-PALPITLPYGGIEERLAFt......
F4GGG6_ALIDK/8-79 ........................RDQALLAACPVVAAPRFGA...LPDM..A..-NGQRIVVARNGWFVQTRLDWLDSITALG.LEPPAMRLPYGEVEERLRFs......
D5WNV4_BURSC/4-76 .......................p-DLMLQRSFPTVMVPRNET...VAEM..L..TAGERLLVAENGVFLEVRRPWLSLVRQVA.EFNVRTAIPYGRVTPSTRLl......
G2ZJ74_9RALS/53-126 ........................LDSKLWDSAPTVAVPKFAE...FQEL..Q..EVGHRFLATAEGLFVEVRRPWLHLIQPVApLNGQTVRPPYGTVKPKVKLa......
A5VG87_SPHWW/8-81 ......................aa---ALLAVVPCYPVPSSGGspaLDALrgS..RAGHGLAVGKDGVMLILRRPWLALDAPVT.-PPIAAYLPYGSIG-----spka...
Q8XYU8_RALSO/53-126 ........................LDAKLWDSAPTVAVPKFAE...FKQL..E..DVGHRFLATAEGLFVEVRRPWLHVIQPVApLNGQTVRPPYGTVKQKVDLa......
G3A6J3_9RALS/53-126 ........................LDAKLWDSAPTVAVPKFAE...FKQL..E..DVGHRFLATAEGLFVEVRRPWLHVIQPVApLNGQTVRPPYGTVKPKVELa......
C6BPY5_RALP1/4-76 ........................RDTYLQSQFPTLPAPKFAP...LERL..E..SVGHRFLVGSNGLALEVRRPWLY-MRKLAlKNEGGLALPYGEVSEAFDLl......
G4FY53_9GAMM/12-79 ........................LDMAVLAAMPLAAVPLDGR...FVAL..E..-TGRRLLAARDGFYIEAANASLYVRWRIA.----ACVTPWGPVTDAIRLr......
F2LSQ3_BURGS/4-76 ........................IDTVLQMSFPTVMVPRREP...VHSM..E..RPGERLLIAANGVFLEVLRPWVRVVRRIA.MYHEKTPIPYGAVDEVTELr......
E6QW91_9ZZZZ/4-75 ........................RDVALQSVMPSVMVPRYSE...LDEL..D..TPGNRILMASNGVWLEVCRAWLYARVPIA.-ASLSIPTPYGAVSEALRFg......
F0B9Z3_9XANT/12-79 .....................qql---AIMLACPLVCVPPGET...MTLL..S..EPGRRWVVASNGTYLEHRSLALHVCFRVS.----KLDTTFGT-------arqfita
#=GC seq_cons ........................hDtsL.suhPoVhVP+aus...lssh..p..psGcRlLluusGlalElpRPWLcllptlu...s.sstlPYGsVpEphchs......
//
