GenomeNet

Database: Pfam
Entry: DUF2016
LinkDB: DUF2016
Original site: DUF2016 
#=GF ID   DUF2016
#=GF AC   PF09436.5
#=GF DE   Domain of unknown function (DUF2016)
#=GF AU   Mistry J
#=GF SE   Iyer L
#=GF GA   19.80 19.80;
#=GF TC   20.00 22.90;
#=GF NC   19.10 19.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   16859499
#=GF RT   The prokaryotic antecedents of the ubiquitin-signaling system
#=GF RT   and the early evolution of ubiquitin-like beta-grasp domains. 
#=GF RA   Iyer LM, Burroughs AM, Aravind L; 
#=GF RL   Genome Biol. 2006;7:R60.
#=GF DR   INTERPRO; IPR018560;
#=GF CC   A predicted alpha+beta domain that is usually fused N-terminal
#=GF CC   to the JAB metallopeptidase. This protein in turn is found in
#=GF CC   conserved gene neighborhoods that include genes encoding the
#=GF CC   bacterial homologs of the ubiquitin modification system such as
#=GF CC   the E1, E2 and Ub proteins [1]. The domain is also known as the
#=GF CC   JAB-N domain.
#=GF SQ   40
#=GS B5S2X2_RALSL/53-126  AC B5S2X2.1
#=GS A1W6B4_ACISJ/8-79    AC A1W6B4.1
#=GS Q120V3_POLSJ/3-73    AC Q120V3.1
#=GS G2ZLL0_9RALS/53-126  AC G2ZLL0.1
#=GS F4G940_ALIDK/7-78    AC F4G940.1
#=GS G6EJV6_9SPHN/10-84   AC G6EJV6.1
#=GS D8NBM4_RALSL/53-126  AC D8NBM4.1
#=GS Q21Q53_RHOFD/9-78    AC Q21Q53.1
#=GS A0R7L0_PELPD/5-76    AC A0R7L0.1
#=GS Q5NUW4_RALME/1-71    AC Q5NUW4.1
#=GS Q7WX35_CUPNH/4-76    AC Q7WX35.1
#=GS Q11ZD2_POLSJ/1-71    AC Q11ZD2.1
#=GS C5T055_ACIDE/7-78    AC C5T055.1
#=GS A9ARU2_BURM1/4-76    AC A9ARU2.1
#=GS B3DAW9_BURM1/1-51    AC B3DAW9.1
#=GS A1VVA1_POLNA/3-75    AC A1VVA1.1
#=GS B1T0G3_9BURK/4-76    AC B1T0G3.1
#=GS D4Z234_SPHJU/10-81   AC D4Z234.1
#=GS F6AR87_DELSC/4-75    AC F6AR87.1
#=GS I0YG13_9BURK/9-81    AC I0YG13.1
#=GS D9SEQ3_GALCS/4-75    AC D9SEQ3.1
#=GS Q1L9T1_RALME/4-76    AC Q1L9T1.1
#=GS F8GZ26_CUPNN/4-76    AC F8GZ26.1
#=GS B1Z672_BURA4/4-76    AC B1Z672.1
#=GS A4JUM8_BURVG/4-76    AC A4JUM8.1
#=GS Q5NXB5_AROAE/4-75    AC Q5NXB5.1
#=GS B2UDC7_RALPJ/4-76    AC B2UDC7.1
#=GS C6BQW2_RALP1/4-76    AC C6BQW2.1
#=GS Q47D11_DECAR/5-75    AC Q47D11.1
#=GS F4GGG6_ALIDK/8-79    AC F4GGG6.1
#=GS D5WNV4_BURSC/4-76    AC D5WNV4.1
#=GS G2ZJ74_9RALS/53-126  AC G2ZJ74.1
#=GS A5VG87_SPHWW/8-81    AC A5VG87.1
#=GS Q8XYU8_RALSO/53-126  AC Q8XYU8.1
#=GS G3A6J3_9RALS/53-126  AC G3A6J3.1
#=GS C6BPY5_RALP1/4-76    AC C6BPY5.1
#=GS G4FY53_9GAMM/12-79   AC G4FY53.1
#=GS F2LSQ3_BURGS/4-76    AC F2LSQ3.1
#=GS E6QW91_9ZZZZ/4-75    AC E6QW91.1
#=GS F0B9Z3_9XANT/12-79   AC F0B9Z3.1
B5S2X2_RALSL/53-126             ........................LDAKLWDSAPTIAVPKFAE...FKQL..E..EVGHRFLATAEGLFVEVRRPWLHVIQPVApLNGQTVRPPYGTVKPKVELa......
A1W6B4_ACISJ/8-79               ........................RDQALLATCPVIAAPRFGT...LPDM..G..-NGQRIIVARNGWFVQTRLDWLDSIVALG.QGLPPMRLPYGEVAEHLRFs......
Q120V3_POLSJ/3-73               ........................LDSIIQGMFPTVIMPREGT...IAPA..T..KNGTRYVVAGDGLWREVVLPWVTVMHKIA.--NSDFMLPYGAAEEAVVIk......
G2ZLL0_9RALS/53-126             ........................LDAKLWDSAPTVAVPKFAE...FKQL..E..DVGHRFLATAEGLFVEVRRPWLHVIQPVApLNGQTVRPPYGTVKPKVDLa......
F4G940_ALIDK/7-78               ........................RDQALLAACPVIAAPRFGA...LPDM..G..-NGQRIIVARNGWFVQTRLDWLDSIVALG.HGSPSMRLPYGEVAEHLCFs......
G6EJV6_9SPHN/10-84              ......................aa---ALIAAAPCYPVPSTGRspaLDAL..RdgRAGHGLAVGKDGVMLILRRPWLALDAPLS.-PPFAAHIPYGSIGE----pkad...
D8NBM4_RALSL/53-126             ........................LDAKLWDSAPTVAVPKFAE...FKEL..E..KVGHRFLATAEGLFVEVRRPWLHVIQPVApLNGQTVRPPYGTVEPKVKLa......
Q21Q53_RHOFD/9-78               ........................IDRFLATDCPVITMPHDSE..vFEPL..K..TPGHRLIVAAGGLYKEIRRAWLHAIVHVA.----RAQTPFGELQTTLSMp......
A0R7L0_PELPD/5-76               ........................MDAILQEQFPTVMVPRYGD...FVPL..A..HNGRRFLSASDGLWLEEKNQWLHILWPLA.-LQNQVAMPYGSLQKKVDFl......
Q5NUW4_RALME/1-71               ........................--MALQQSFPSVMVPRHGA...LPAL..E..QVGERLLIAANGVFLEIVRPWLRVVRRLG.EFQHQTAIPYGDATEVTELr......
Q7WX35_CUPNH/4-76               .......................a-DAALQQSFPSVMVPRFGA...LAPM..E..RSGERLLIAANGVFLEIVRPWLSVVRHLG.AFQHRTAIPYGEAAETTDLr......
Q11ZD2_POLSJ/1-71               ........................MDAIIQSQFPTVLAPRFEA...LSPL..E..TTGDRFILTRHQVLMEVSRPWLHAIQAIS.-APFARQTPYGA-------gprlgik
C5T055_ACIDE/7-78               ........................RDQALLAACPVIAAPRFGA...LPDM..G..-NGQRVIVARNGWFVQTRLDWLDCIVALG.HGQPLMHLPYGEVAEHLRFs......
A9ARU2_BURM1/4-76               ........................VDTVLQQSFPSVMVPSREA...VVPM..T..RSGERLLITSDGVYLEVLRPWVRVVRRIA.HYAVSTAVPYGQVEETTAFs......
B3DAW9_BURM1/1-51               ........................-------------------...---M..T..RSGERLLITSDGVYLEVLRPWVRVVRRIA.HYAVSTAVPYGQVEETTAFs......
A1VVA1_POLNA/3-75               ........................LDQITMGVFPLLAASQTGV...LQDP..E..KHGVRYVAASDGMWRAIDTAWLKALTPVA.LSSKKAVIPYGRLTQSVEFl......
B1T0G3_9BURK/4-76               ........................LDTVLQQSFPSVMVPSREA...VVPM..A..RSGERLLIASDGVYLEISRPWVHVVRRIA.QYAVSTAVPYGNVEETTELl......
D4Z234_SPHJU/10-81              avlaavpchpvpplgkspaldalr-------------------...--S-..A..RSGHGLAVGSDGVMLILRRPWLALDVPVT.-PPIAAYLPYGSVG-----apka...
F6AR87_DELSC/4-75               ........................RDQALLAACPVVAAPRFGA...LPDM..A..-NGQRIIVARNGWFVQTRLDWLDSITALG.LEPPAMRLPYGEVREHLRFs......
I0YG13_9BURK/9-81               .......................a-DAALQRSFPTVMVPRREP...VAPM..Q..AAGERLLIGENGVFLEIDLRWLSVVRRIA.HYTVPTAIPYGKVAESTELr......
D9SEQ3_GALCS/4-75               ........................RDVALQSVMPTVMVPRYAE...LEEL..D..TPGNRILMAENGVWLEVCHAWLYARIPVS.-LPLRIPVPYGVIYEELRFg......
Q1L9T1_RALME/4-76               ........................ADMALQQSFPSVMVPRHGA...LPAL..E..QVGERLLIAANGVFLEIVRPWLRVVRRLG.EFQHQTAIPYGDATEVTELr......
F8GZ26_CUPNN/4-76               ........................MDITLQQSFPSVMVPRFGE...LAPL..E..ATGERLLIAANGVFLEVSRPWLRLVRRVG.QFDVKTAVPYGTAAEATDLr......
B1Z672_BURA4/4-76               ........................LDTVLQQSFPSVMVPSREP...VAPM..T..RSGERLLIASDGVYLEVLRPWVRVVRRIA.QYAVSTAVPYGKVDETTALl......
A4JUM8_BURVG/4-76               ........................LDTVLQQSFPAVMVPSRET...VVPM..T..RSGERLLIASDGVYLEVLRPWVRVVRRIA.QYAVSIAVPYGKVEETTALl......
Q5NXB5_AROAE/4-75               ........................RDMALQALTPTVMVPRFGC...FEPL..S..QPGHRFLVGQNGEWLEVRRAWMYARVQLT.-QPSPVVKPYGVVTACLEWl......
B2UDC7_RALPJ/4-76               ........................MDMTLQASFPTIMVPKFGS...LTPL..S..GSGERLLVGTNGVFLEVVRPWLRVVRKIA.SYEVETAVPYGTVNEETELp......
C6BQW2_RALP1/4-76               ........................MDMTLQASFPTIMVPKFGS...LTPL..S..GSGERLLVGTNGVFLEVVRPWLRVVRKIA.SYEVETAVPYGTVNEETELp......
Q47D11_DECAR/5-75               ........................RDLALQAVCPVIAAPRFGP...LPDM..A..-NGQRIILAANGVFVQVKLDWLDCIQRLS.-PALPITLPYGGIEERLAFt......
F4GGG6_ALIDK/8-79               ........................RDQALLAACPVVAAPRFGA...LPDM..A..-NGQRIVVARNGWFVQTRLDWLDSITALG.LEPPAMRLPYGEVEERLRFs......
D5WNV4_BURSC/4-76               .......................p-DLMLQRSFPTVMVPRNET...VAEM..L..TAGERLLVAENGVFLEVRRPWLSLVRQVA.EFNVRTAIPYGRVTPSTRLl......
G2ZJ74_9RALS/53-126             ........................LDSKLWDSAPTVAVPKFAE...FQEL..Q..EVGHRFLATAEGLFVEVRRPWLHLIQPVApLNGQTVRPPYGTVKPKVKLa......
A5VG87_SPHWW/8-81               ......................aa---ALLAVVPCYPVPSSGGspaLDALrgS..RAGHGLAVGKDGVMLILRRPWLALDAPVT.-PPIAAYLPYGSIG-----spka...
Q8XYU8_RALSO/53-126             ........................LDAKLWDSAPTVAVPKFAE...FKQL..E..DVGHRFLATAEGLFVEVRRPWLHVIQPVApLNGQTVRPPYGTVKQKVDLa......
G3A6J3_9RALS/53-126             ........................LDAKLWDSAPTVAVPKFAE...FKQL..E..DVGHRFLATAEGLFVEVRRPWLHVIQPVApLNGQTVRPPYGTVKPKVELa......
C6BPY5_RALP1/4-76               ........................RDTYLQSQFPTLPAPKFAP...LERL..E..SVGHRFLVGSNGLALEVRRPWLY-MRKLAlKNEGGLALPYGEVSEAFDLl......
G4FY53_9GAMM/12-79              ........................LDMAVLAAMPLAAVPLDGR...FVAL..E..-TGRRLLAARDGFYIEAANASLYVRWRIA.----ACVTPWGPVTDAIRLr......
F2LSQ3_BURGS/4-76               ........................IDTVLQMSFPTVMVPRREP...VHSM..E..RPGERLLIAANGVFLEVLRPWVRVVRRIA.MYHEKTPIPYGAVDEVTELr......
E6QW91_9ZZZZ/4-75               ........................RDVALQSVMPSVMVPRYSE...LDEL..D..TPGNRILMASNGVWLEVCRAWLYARVPIA.-ASLSIPTPYGAVSEALRFg......
F0B9Z3_9XANT/12-79              .....................qql---AIMLACPLVCVPPGET...MTLL..S..EPGRRWVVASNGTYLEHRSLALHVCFRVS.----KLDTTFGT-------arqfita
#=GC seq_cons                   ........................hDtsL.suhPoVhVP+aus...lssh..p..psGcRlLluusGlalElpRPWLcllptlu...s.sstlPYGsVpEphchs......
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