#=GF ID   DUF2100
#=GF AC   PF09873.4
#=GF DE   Uncharacterized protein conserved in archaea (DUF2100)
#=GF AU   COGs, Finn RD, Sammut SJ
#=GF SE   COGs (COG4024)
#=GF GA   22.20 22.20;
#=GF TC   22.20 141.00;
#=GF NC   21.90 22.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR019210;
#=GF CC   This domain, found in various hypothetical archaeal proteins,
#=GF CC   has no known function.
#=GF SQ   22
#=GS A6VGF7_METM7/3-219  AC A6VGF7.1
#=GS G0H1F7_METMI/3-219  AC G0H1F7.1
#=GS Q8TYT1_METKA/3-218  AC Q8TYT1.1
#=GS A6UVA6_META3/3-222  AC A6UVA6.1
#=GS E3GY18_METFV/4-217  AC E3GY18.1
#=GS D9PY54_METTM/5-218  AC D9PY54.1
#=GS Y1481_METJA/2-212   AC Q58876.1
#=GS D3S497_METSF/2-212  AC D3S497.1
#=GS Q6LXX8_METMP/3-219  AC Q6LXX8.1
#=GS D5VT50_METIM/1-205  AC D5VT50.1
#=GS A4FWW0_METM5/3-219  AC A4FWW0.1
#=GS F6BAF4_METIK/5-216  AC F6BAF4.1
#=GS F8AMM9_METOI/3-225  AC F8AMM9.1
#=GS C7P9M9_METFA/2-214  AC C7P9M9.1
#=GS Y1195_METTH/5-218   AC O27263.1
#=GS F6D2W6_METSW/4-219  AC F6D2W6.1
#=GS C9RHR0_METVM/2-216  AC C9RHR0.1
#=GS H1KWQ6_9EURY/5-216  AC H1KWQ6.1
#=GS D7DRW1_METV3/4-247  AC D7DRW1.1
#=GS F0T8P0_METSL/4-220  AC F0T8P0.1
#=GS A6UPL7_METVS/3-220  AC A6UPL7.1
#=GS A9AA95_METM6/3-219  AC A9AA95.1
A6VGF7_METM7/3-219             ............ETQHSKELIKRAVETISKTKTV...STTQNl.............sqNNDKKT..FSDAKAGKIDTLEFKKAVHSLFEADEDLYKYAPNHDLDEEKAKEFSKLLFEAQKHINNVLSGFGF.DF....E-T.ISLDG...QALYIVSNKKVLKSL.KDI.NP............DLNIISTEGVLEIEDMKVVNPKIPEKALLGIEKKCKITKEQISKVISNISPSKVVVLVKDGDVADELIYIR....AKEL.YNAE........KLNADEIL.............
G0H1F7_METMI/3-219             ............ETQYSKELIKKAVETISKAKTV...SATQNf.............ekNENKKT..FSDAKSGKIDTIEFKKAVHSLFEADEYLYKYAPNHDLDEEKAREFSKLLFDAQKHINNVLGGFGF.DI....E-T.VALDG...QALYIVSNKKVLKSL.KDI.NP............DLNIISTEGVLEIEDMKVVNPKIPEKALLGIEKKCKITKEQISKVISNISPSKVVVLVKNGDVADELIYKR....AKEL.YNAE........KLNADEIL.............
Q8TYT1_METKA/3-218             ............RVERLEELLSHAVSQRSGRIRV...-----................------..VTDVDELRLDEEVVRRIVHRAAELDHALVESAPEHVLRGERAQEVARAL---DDILRSVLELVGV.EE....ETE.RDLDDlfkDSVLVVVRGRERKAL.REL.V-............DAPIVQTGGPLVPEDYRKVNPNLPEKLPEGLVKSVERARRELEEYIRKSGAKRIVLVREEDDRVGEVLEEElpevAEELgVDHEvivvpdftELSPSDLL.............
A6UVA6_META3/3-222             ............ELNNSKILLKKAVGTISKIEKS...KPITTa.............tpQLINEK.sWKDAEPGVINSGELKKMMYSAIEADDYLGKTAPTHKLNKEQAEEFCKILFQTKKHIDKILKEFGF.EI...tEGA.PKLNE...NSLYIVGNKKTLKNL.KNI.EP............NLNIISTEGVLEPEDMKIINPKINDKALIGIEKKCNIVKNQINDLINKVNPSTVVVVVDKNNNADELIYNS....AKKH.WNAI........KIDIETIL.............
E3GY18_METFV/4-217             ..........ir-IKQCERLIKKASK-------S...KPKIK................SKDKIT..INKVKEGQIDIETLNDAINKLLESETFIYKTLPSRKIKGKDAQEFCNNLMFVKKKIEKILSDFDV.IK....TVE.EEIPK...EILIVTQNTRIKKRL.QDIgVD............PRQIIVAGVPLALEDMKEINPNIPEHALKNIEKRIKVIKNEISRKIKHF--EKILVVVQ-KDKSGKLLAKR....AKEL.YNAE........VM------fcedpkdidlhkl
D9PY54_METTM/5-218             ............RLEQAEELIRKSCTNIRRESR-...-----................------..FRDPHDGVIDTRKFQEALMELIEAEDHIYASLPSHELTGEDAYDFCRRLMASREAIDGMLADFGViER...eDPS.ERIKEaskGKLILVNNSSVKKLLvKAG.VE............PGNILVAGAPLSVDDMKKINPRIPDAALKGIEKKIEHLKNDIER---KLEDLGEILVIGEPDKSTGLLASR....AEEL.YGAGvrlnenirDLTPEEIL.............
Y1481_METJA/2-212              ............RVEYSKDLIRKGISTISQLKKA...KIRVE................KDDKKI.sYKDAKPGKIDVNEFKKAIYLLIEADDFLYKKAPKHELNEEEAKEFCKLIIKCQEHLNKILANFGF.EF....E-E.KEIDE...GALYIVSNKKLFKKL.KNK.NP............NLKVVCTEGMLDIEDMRAIG--VPEKALEGLKKKVEIARKNVERFIEKYKPEKIFVVVE--DDKDELLYLR....AKNL.YNAE........KLDADEIL.............
D3S497_METSF/2-212             ............RTEYSKDLIRKGISTISQLKKA...KVKVE................KADKKI.sYKDAKPGKIDVGEFKKAVYLLIEADDFLYKKAPKHELNEEEAKEFCKLIIKCQEHLNKVLSNFGF.EF....E-E.KEISE...DALYIVSNKKLFRKL.KNK.NP............NLKVVCTEGMLDIEDMKAIG--VPEKALEGLKKKVEIARKNVERFIEKYKPDKIFVVVE--DDKDELLYLR....AKNL.YNAE........KLDADEIL.............
Q6LXX8_METMP/3-219             ............ETQYSKELIKKAVETISKAKTV...SATQNf.............ekNENKKT..FSDAKSGKIDTIEFKKAVHSLFEADEYLYKYAPNHDLDEEKARAFSKLLFDAQKHINNVLGGFGF.DI....E-T.VALDG...QALYIVSNKKVLKSL.KDI.NP............DLNIISTEGVLEIEDMKVVNPKIPEKALLGIEKKCKITKEQISKVISNISPSKVVVLVKNGDVADELIYKR....AKEL.YNAE........KLNADEIL.............
D5VT50_METIM/1-205             ..........mr----EKSLIKKGIETITLLSRR...---KV................TEERRS..YNEARAGTINTEEFKKAIHYLIEADSYLYKKSPKFYLNDEEAKEFCKLIFKAKDSLDKVLSNFGF.SF....YKE.EELDE...SSLYIVSNRKLFKKL.KSK.NK............NLKVVCTEGLLDIEDFKKIG--VPESALKSLEKKVEMAKKNIERFIEKYKPNKIYVVVE--DEKDNLLFER....AKKL.YNAE........KVEIDEL-.............
A4FWW0_METM5/3-219             ............ETQYSKELIKKAVETISKTKAV...ATTQNp.............sqNNDKKT..FTDAKAGKIDSSEFKKAVHSLIEADEYLYKYAPNHDLDEEKAKEFSKLLFEAQKHINNVLGGFGF.EF....E-T.VSLDG...QALYIVSNKKVLKSL.KEI.NP............DLNIISTEGVLEIEDMKVVNPKIPEKALLGIEKKCKITKEQISKVISNISPSKVVVLVKDGDVADELIYKR....AKEL.YNAE........KLNADEIL.............
F6BAF4_METIK/5-216             ............RVEDSKNLIIKAISTISEIERM...-GKPS................ADSKTI.sYKDAKAGKINVDEFKKAIYALIEADEFLYKKAPLHELNEEEAKEFCRLILKAERHLNNVLKDFGF.EF....E-E.KEIDK...NALYIVSNKKLFRKL.KDK.NP............DLNVICTEGMLDIEDMKTINPNIPEKALEGIKKKIEITKNNIAKRIEKTKPSKVVVVVE--DKADELIYNR....AKEL.YNAD........KIDVNELL.............
F8AMM9_METOI/3-225             ............RLNDSKILIKKAVNTIDKLDYE...LKLKNntk.........tktiSESKSI.sYKDAKSGTINVDEFKKAVYAIIEADDYLYKKAPLHNLNDDEAKMFCKLVFQTQKHLNNVLKAFGF.EF....EEG.AQLDE...SALYIVSNKKLLKNL.KNK.MP............NLNIISTEGILEAEDMKVINPNMPEGALKGIEKKCNITKEQITKLINKLNPSKVIVIVDDSNKADELIYIR....AKEL.YGAE........KISIDDI-d............
C7P9M9_METFA/2-214             ............RVEYSKELIRKGISTISQLKKA...KVKVEk..............tEGKKKI.sYRDAKPGKIDINEFKKAVYLLIEADDFLYKKAPKHELNEEEAKEFCKLIIKCQEHLNRLLANFGF.EF....E-E.KEISE...NALYIVSNKKLFKKL.KNK.NP............NLKVVCTEGMLDIEDMKAIG--IPEKALEGLKKKVEIARKNVERFINKYNPEKIFVVVE--DDKDELLYLR....AKQL.YNAE........KLNADEIL.............
Y1195_METTH/5-218              ............RFEQAEKLIRKSCINLKREQG-...-----................------..FRDASDGVIDTGKLQEAMMELIDAEEYLYTSLPTHELGGEDASEFCRKLIAAREAIDHILADFGVlER...qDPS.ERIREaarGKLIIVNNSSVKKLLvKAG.VE............AQNILVAGAPLSVDDMREINPKIPESALRGIEKKIEHLRNDIER---KLDALEDVLVVGEPDKSTVLLAAR....AEEL.YGADsrlmenikDLNSEDIL.............
F6D2W6_METSW/4-219             frlkqtqsllke----------------------...-AEKS................KNTAEK..LKTPKEGKIDVDLFVEILNDMIEAEEFIYSSRPSQKLDDNNAKLFCNSIINIRHKLDEILADFGViEKesveEEI.KKLSE...NFLILTTKSSFKKALnKLG.VE............PQRIIVAGVPLEVEDMKLINPKIPESAFGAIKKKIDHVKHDISRKKDQFNPTDILVVVE-HDKSGEILGSR....AHEL.YNAH........IIVTD---nlkditaeef...
C9RHR0_METVM/2-216             ...........r-EEQSKELIRKGISTITRLKRSgqeKIKVE................KSDKKTisYKDAKPGKIDINEFKKAVYLLLEADDYLYKKAPKHELDEKESKEFCKLIIKCQNHLNKILSNFGF.EI....E-E.KDIDE...DALYIVSNKKLFKKL.KNK.NP............NLKVVCTEGMLDIEDMKKIG--VPENALVGLKKKIELARKNIERFIEKYKPEKILVVIE--DKKDELLYIR....AKEL.YNAE........KIDVDELL.............
H1KWQ6_9EURY/5-216             ............RMEDSKNLIIKAISTISEIERR...EKPPV................DAKKVS..YKDAKPGKIDTNELKKAIYVLIEADEFLYKKAPLHELNEEEAKDFCKLILKAEKHLNNVLKNFGF.EF....E-E.KEIDK...DALYIVSNKKLFRKL.KDK.NP............DLNVICTEGMLDIEDMKAINPNIPEKALGGIKKKIEITKNNIAKRIEKTKPSKILVVVE--DKADELIYKR....AKDL.YNAD........KINAEELL.............
D7DRW1_METV3/4-247             ...........q-LKNSQELLKKSIESISKLEQE...KLIEIkkqdmgnmsentqetaKKNEKT..YKDAEAGIIDIAELKKAAYDLIDADEYVYKKAPNHELTKEEAEEFTKIILGAQKSLSTVLEAFGF.EQ....EKNiINLDS...DALYLVSNKKLIKIL.NEI.NEeankamgitlktNLNIISTDGVLKPEDMLIINPKMPEKALKGIEKKCAITKENIQKIIANKKPSKVYVVVKEGDKADELILKR....AEAL.YGAK........KLPLEEL-q............
F0T8P0_METSL/4-220             frikqaenllks----------------------...-AAKN................KTKNKE..LKNAKPGFINVDIYESVINNLLEAEEFIYSSRPIHKLDSEDATKFISKILASRKDIDVILSDFGViDK...tAPE.EDVKEnfkDYLILTTKNNFKKTIsKFG.ID............TQKIVVAGVPLVPEDMQILNPKMPESALGPIAKKIQHVKNDIERKMEQFQLENMVVLVE-SDKSGELLSKR....AKEM.YNAKiv...vveN-------lkditveefi...
A6UPL7_METVS/3-220             ............ETKVSKELIVKAIETISKTKKE...FEIVSd.............piKAEKKI..YSDAISGKINGNEFKRAVQSLFEADEYLYKTAPNHELNSEQAKEFSKLLFDVQKHINKILSEFGF.NL....EDK.ISIDR...KALYIVSNKKLLKSL.KEI.DS............DLNILSTEGVLEIEDMKIVSPEIPEKALLGIEKKCKIIKEQISKVILNINPSKIYVVVKSGDTADELIFKR....AKEL.YGAE........KLNSEELL.............
A9AA95_METM6/3-219             ............ETQYSKELIKKAVETISKTKTV...STTQNl.............sqNSDKKT..FTDAKAGKIDSSEFKKAVHSLIDADEYLYKYAPNHDLDEENAKEFSRLLFEAQKHINNVLSEFGF.DF....E-T.ISLDG...QALYIVSNKKILKSL.KEI.NP............DLNIISTEGVLEIEDMKVVNPKIPEKALLGIEKKCKITKEQISKVISNISPSKVVVLVKDGDVADELIYKR....AKEL.YNAE........KLNADEIL.............
#=GC seq_cons                  ............chp.SKcLI+KulpTISchcp.....hh.p................pppKch..apDAKsG+IDssEFKKAlapLIEAD-aLYKpAPpH-Ls-EcA+EFsKLlhpsp+HlsplLusFGF.Eh....E.p.tclDc...sALYIVSNKKlhKpL.Ksh.ss............sLsIlsTEGsL-lEDMKhINPpIPEKALtGIcKKscIsKcpIp+hIpphpPsKllVVVc..DcuDELlapR....AKEL.YNAE........Klss-ElL.............
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