GenomeNet

Database: Pfam
Entry: DUF2115
LinkDB: DUF2115
Original site: DUF2115 
#=GF ID   DUF2115
#=GF AC   PF09888.8
#=GF DE   Uncharacterized protein conserved in archaea (DUF2115)
#=GF AU   COGs, Finn RD, Sammut SJ
#=GF SE   COGs (COG4066)
#=GF GA   25.00 25.00;
#=GF TC   44.50 43.90;
#=GF NC   24.20 21.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR019215;
#=GF CC   This domain, found in various hypothetical archaeal proteins,
#=GF CC   has no known function.
#=GF SQ   77
#=GS Y665_METMP/2-159         AC P60818.1
#=GS A0A166BBH1_9EURY/20-182  AC A0A166BBH1.1
#=GS Q0W0W4_METAR/17-189      AC Q0W0W4.1
#=GS A0A101ISX1_9EURY/34-111  AC A0A101ISX1.1
#=GS J1L5A7_9EURY/21-191      AC J1L5A7.1
#=GS F6D7G5_METPW/15-175      AC F6D7G5.1
#=GS I7L107_METBM/79-241      AC I7L107.1
#=GS Y646_METJA/2-160         AC Q58062.1
#=GS A0A162FK07_9EURY/15-177  AC A0A162FK07.1
#=GS F0T6P2_METLA/4-128       AC F0T6P2.1
#=GS Y812_METTH/2-160         AC O26903.2
#=GS Q12YF8_METBU/10-167      AC Q12YF8.1
#=GS A0A125RBM0_9EURY/20-180  AC A0A125RBM0.1
#=GS Q2FNU7_METHJ/30-191      AC Q2FNU7.1
#=GS A0A162FHE5_9EURY/15-177  AC A0A162FHE5.1
#=GS I7KZ45_METBM/22-182      AC I7KZ45.1
#=GS A2SQ90_METLZ/26-184      AC A2SQ90.1
#=GS F6D7G4_METPW/24-182      AC F6D7G4.1
#=GS D5EBF8_METMS/8-166       AC D5EBF8.1
#=GS E1RKK7_METP4/2-154       AC E1RKK7.1
#=GS E3GYV3_METFV/11-169      AC E3GYV3.1
#=GS R9SIV5_9EURY/3-149       AC R9SIV5.1
#=GS C8VWC1_DESAS/2-158       AC C8VWC1.1
#=GS A0A166BU60_9EURY/2-148   AC A0A166BU60.1
#=GS A3CUT9_METMJ/6-168       AC A3CUT9.1
#=GS E1RF46_METP4/21-182      AC E1RF46.1
#=GS U6EA65_9EURY/15-173      AC U6EA65.1
#=GS D1YZJ5_METPS/35-197      AC D1YZJ5.1
#=GS Q2NHX8_METST/2-152       AC Q2NHX8.1
#=GS A0A0N8W8N9_9EURY/33-204  AC A0A0N8W8N9.1
#=GS R9SKF2_9EURY/15-175      AC R9SKF2.1
#=GS A0A101DP15_9EURY/12-172  AC A0A101DP15.1
#=GS Q2FL19_METHJ/21-192      AC Q2FL19.1
#=GS K4LFF1_9FIRM/18-173      AC K4LFF1.1
#=GS A7I898_METB6/33-193      AC A7I898.1
#=GS F0TAZ0_METLA/15-175      AC F0TAZ0.1
#=GS F6D7G3_METPW/41-199      AC F6D7G3.1
#=GS A0A126R3V5_9EURY/2-160   AC A0A126R3V5.1
#=GS Y666_METKA/2-137         AC Q8TXK6.1
#=GS A0A101IWL6_9EURY/70-232  AC A0A101IWL6.1
#=GS A0A101J0M9_9EURY/29-197  AC A0A101J0M9.1
#=GS E1RH52_METP4/29-200      AC E1RH52.1
#=GS K4MED9_9EURY/2-160       AC K4MED9.1
#=GS D7E9K9_METEZ/2-160       AC D7E9K9.1
#=GS U6EC76_9EURY/13-172      AC U6EC76.1
#=GS A3CXE2_METMJ/58-229      AC A3CXE2.1
#=GS A5UJ91_METS3/3-149       AC A5UJ91.1
#=GS A6UW08_META3/2-163       AC A6UW08.1
#=GS R9SM74_9EURY/15-177      AC R9SM74.1
#=GS A0A166E6F3_9EURY/21-180  AC A0A166E6F3.1
#=GS A0A166ET54_9EURY/15-173  AC A0A166ET54.1
#=GS A0A126QYH6_9EURY/16-174  AC A0A126QYH6.1
#=GS B8GKS1_METPE/34-196      AC B8GKS1.1
#=GS A0A117LRJ2_9EURY/77-239  AC A0A117LRJ2.1
#=GS D3E3I4_METRM/20-177      AC D3E3I4.1
#=GS E1RKK9_METP4/41-212      AC E1RKK9.1
#=GS L0HI22_METFS/76-238      AC L0HI22.1
#=GS F0TAZ1_METLA/15-173      AC F0TAZ1.1
#=GS B8GKT1_METPE/36-208      AC B8GKT1.1
#=GS D7DU54_METV3/2-156       AC D7DU54.1
#=GS B8GII9_METPE/31-202      AC B8GII9.1
#=GS A0A125RC62_9EURY/22-179  AC A0A125RC62.1
#=GS H1YYU4_9EURY/19-191      AC H1YYU4.1
#=GS D3E0U5_METRM/2-158       AC D3E0U5.1
#=GS A0A166EXB2_9EURY/15-177  AC A0A166EXB2.1
#=GS A0A0Q1FDF7_9EURY/33-204  AC A0A0Q1FDF7.1
#=GS B8GG14_METPE/6-153       AC B8GG14.1
#=GS Y811_METTH/3-152         AC O26902.1
#=GS D5VU42_METIM/2-152       AC D5VU42.1
#=GS L0HGV6_METFS/29-200      AC L0HGV6.1
#=GS A5UK44_METS3/20-180      AC A5UK44.1
#=GS J0S9P9_9EURY/35-197      AC J0S9P9.1
#=GS A7IAC9_METB6/28-199      AC A7IAC9.1
#=GS A2STY9_METLZ/48-217      AC A2STY9.1
#=GS H1Z2H4_9EURY/18-178      AC H1Z2H4.1
#=GS A0A125RCQ9_9EURY/2-148   AC A0A125RCQ9.1
#=GS A3CTH3_METMJ/19-180      AC A3CTH3.1
Y665_METMP/2-159                    ......................k-SRKFFSKLKEESYDVSIFDLMNAKVYLEKDMTYLP..QDYKKGYIEDFFTFFPEVLKEIKN.-KTEEEIEDF--EIEDEEIKRVELRLCSMGSKQTG--........RESYEKLVKTVINYLIFINERPLHALTTRFPGG.KQIIEK....NG....NYYCPIKN..A..QSN-ELSICEFCICKD-l..........
A0A166BBH1_9EURY/20-182             ......................s-KKELITILKKYARNISPYDLMLATARMRKDGEYVQ..KQYREKFLKIYIENFLMRMKEVLD.----NDDELK-GNIDKNKFINSFPLLKTTFEKERSETyn....vdDDKFPLIYVITSLYTTFILNEPIHPVGSEFPGS.LKVENR....KG....TYYCPVKD..N..QKDNEHAICHLCLAEQT...........
Q0W0W4_METAR/17-189                 ......................l-KRELAQELADEINRFSVYDLQYVSARLEKDISDLP..SPYREKIRPYFMEQYFGRYNRIMTmRGSGELEKIEGEIKDPELFRDFCRMITARYPDRELQDepeeytqgSPFNSLFYYLISIFYMFVLDEPGHPAGMPFPGG.FTVREH....DG....VVYCPIRD..K..EKDVEYSICNFCPAKQD...........
A0A101ISX1_9EURY/34-111             ......................a-RAELADILYREVAGYSLFDLQAMRGRVEQDLRSVP..AGYRRRLYPRMMEMIFETHHTLIAtMRRSGL-------------------------------........---------------------------------.------....--....--------..-..-----------------evqdeplteef
J1L5A7_9EURY/21-191                 .......................TRGELGRAIAEEAGRFSLYDLQRIGGGIRREVEALP..EPYRSRVRPYFEEQIFGAYHRLMCsHRSGAFARMDDPIPDPEHFSAFVALIPRGCLDRKGSQtdi..gfsKPLHTLFYYLVTGYTIFVEGGPGHPVGTPFPGG.FAVERR....GN....EYYCPIRD..K..EEDVPFSICNVCPARQM...........
F6D7G5_METPW/15-175                 .......................KKTDLLVVLKEEVSNIHITDIMRASAFLKEDAKYVQ..ASYREGYRKAYVEGFILRITDLKN.----DKSQH-GGYVDLEEFKKALNLLGDQRAQLEIEGn......fDPCFSKLYVTMSLYTSFILEEPIHVVGTPFPGG.FEVKFQ....DG....EYLCPVKD..K..QKDNPGAVCGFCIAKQE...........
I7L107_METBM/79-241                 .......................TKGELLHIIAGEVGAFDLHDLEAMNAGFERKVASLP..EDYRDRLLASVREEIFGAHHRLVLlSRNGAAPSMDSP--PAPAHAAYWAMVAEACTEKAREK........DPRYLYLKYLLSGFAMFVLAEPAHPVGTPFPGG.QIVDEW....EG....AYLCPVRD..M..ADDVPFALCPYCPAAQS...........
Y646_METJA/2-160                    ......................k-ARELFEKLKKELNNFSIYDIMMIRSFIEKDAKYLP..PQYKNHYVEAMMKYLIETFNEIRK.-KSVDEIQD--EEIDEEKLNEMLNRIERFRKYYTPD-........EERFINLSKILCPYLAFIAKKPLHPEYLTFPGN.VKIIKK....GN....NYYCPVKN..K..QLN-EYSLCEFCVCKS-i..........
A0A162FK07_9EURY/15-177             ......................s-KNDVLKVLKKGAKDISIFDIMNSTNNFRQACKYVR..DEYKGYFDDIYIKNFYMKVKDISS.----DNNSYE-SYINKNKFLKSIDYFQKQDQDREEIDld....nsYEKQRLIYYLICIYTTYVLDEPIHAVGSVFPGH.TTVRQV....GD....LYYCPVKA..N..NSNNPKAVCRYCIAHQ-g..........
F0T6P2_METLA/4-128                  ................pktdidd------------------------------------..-----ELQGAMSSYNAENFRRLTE.---THFSGE-DEEINTKELTALEESIDHYFELYAPD-........NIEFREFIKIVSVYLTFIEKRPLHPPGIIFSGG.DTVYEN....KG....IYYCTGKK..Q..FKNDDHSLCNFCVCHE-i..........
Y812_METTH/2-160                    ......................t-EMQLLEMLKKEASSVHIKDIMSASVYLREDARYLP..PREQKEFIERFTRAFFNRIRDIKN.----DKNIYQ-GHVDTAGLKEFIDFLDQQLSQAKTEN........ERCFQKIARIITIYVTFVRKEPVHPVGTRFPGG.FTVRRE....GN....VFYCPVKD..R..QINTPGALCRFCVSIQD...........
Q12YF8_METBU/10-167                 ......................d-TKELLASLEKDARRISNNDIMKARSFMLNYVKFLP..EKYKKAYSTELFSYYYETFMEIKG.LRSNPVIE----EIDIETYNELVKNYSQQFNEDPL--........ESYFQRFMSVVTPYLIFITKKPLHPVGMILPGG.MTIMEP....NG....EYYCPIKN..K..QTEVDIALCKYCICKD-n..........
A0A125RBM0_9EURY/20-180             .......................TRKELMEILKKYARIISVYDLMMATAYMRKDGEYVH..ENYREKYLEIYIKYFIMRMKEVLE.-----NDSYEDGVIDKNAYDESFPMLERTFEKERLSNn......dDDKFPLIYVITALYTTFILEEPIHPVGSEFPGH.LKVEER....NG....TFLCPVKD..N..QKDNVNAICHLCLAEQT...........
Q2FNU7_METHJ/30-191                 ......................m-RGDLGLAIADIVLTYSPNDLKQMKVNFSGKIDSLS..PDYKKELEETIAVFLDGTYQNIRLmNQQGSFATIQEPVSDQA--KEYWMMVADRCSTGDIP-........GNRLRFLKFLLSGFCMFVQEIPGHPVGMPFPGG.DKVDFI....DG....KYYCPVRT..K..SHDVDAALCPFCPAEQT...........
A0A162FHE5_9EURY/15-177             ......................y-KNDLLDALKKYAKNISIFDIMSSTSNFRDACKYVR..DEYKGHFDDIYIKNFYMKVAEIGI.----DDKEYN-EKIHKKKYLKAIDFFSNQDENREEEDpe....neFKKQRQIYYLICIYTTFILEEPIHAVGSIFPGH.TKVRED....NG....KFYCPVKA..N..NTTNPKAVCRFCLAHQ-g..........
I7KZ45_METBM/22-182                 ......................t-RAELAEVLYREVSGYSLFDLQALRGRVERDLRSLP..AGYRQRLYPRVMEQLFDTHHALIStARRGDLDALDEP--LTGQFQEFCGMVEKTCLTLES--........DPRLSLLYYLLAAFNLFVLDRPGHPVGTPFPGG.FEVEVR....NG....EYVCPVRE..K..ADDVENALCPYCPAKQS...........
A2SQ90_METLZ/26-184                 ......................r-KGALLALLKEKGQLYSPEDLELMLNRYAKKLENVP..KEYGDSLMQYARIQIVDGYHRMMT.---DELTPIHAAVLLPPSWKAFTADARRAASKGTP--........GDRLRSLKYLIAAYSVYIKDEPVHPVGMPFPGG.FSVEQY....DG....EYYCPVRA..V..WNDIDDAFCKYCPAIQ-s..........
F6D7G4_METPW/24-182                 .......................KKEELVEILKNDADDISIRDLMEIYTNMLKEGRYVQ..KSYHEDYIRFYIKSFSKYLKGLKT.----DETPYN-SYVDMEKLRGTVEHLQKMFEESERDS........SPGSKKILYLTSIYSTFVLEEPIHIVGSQFPGG.LKVKKN....GE....TYLCPVKD..K..QKESPNALCKFCIAEQE...........
D5EBF8_METMS/8-166                  .....................ng--QELITNLKNKANRFTPSDFMKIRSRILQSTENLP..SKYRQMYGEELFRHLYETIDEIRK.----YKATPQLPTFDRKDCLELIQRIDLMREEDNEK-........NKLFTDMVKLTSIYLIFVAGKPLHPLNMEFPGG.RKIAKK....DN....AYYCPVKN..K..QKDVEIALCKFCICKDM...........
E1RKK7_METP4/2-154                  ......................k-ASELFEAIKDDLSTISEY------ISLMKCIHETN..SKDSATQSSILVEYDYAAYREIMN.----EACPNPDIVIESDRVEEFREALNRYFDEYAPG-........ETDLRCYVTNISLYLVFIAKKPLHPPGIDVPDL.KVIKGE....DG....HYYCSRKG..K..IFDGEPTLCRYCVCR--pi.........
E3GYV3_METFV/11-169                 ......................s-KRKLLHILKKASRKVSVNDLMNASVFLNEEIKYMH..KQEKKEYIRRFMHAFFMRLNELKN.----DKKRYE-GSVDIKKLKELVDFMENKIKNSKSEK........ERSFYKIAAIVSIYATFVKEVPIHPLSTKFPGN.LKIRYR....KG....KYLCPVKD..K..QKESPEALCKFCVAVQD...........
R9SIV5_9EURY/3-149                  .........tmntkelfdeiyey--------------------------MINYDHARVP..HGYSTDAISLLTRYNYYTYKEIIN.RKHSGSLKV---EVDDNKVNDFKDRVDYYFEENSPG-........DYEYRDFIKYISLYLTFIVRKSLHPVGIKSKD-.MTVTKD....NN....KFYCTGKK..R..FIKDRNSLCKYCVSR--sk.........
C8VWC1_DESAS/2-158                  ......................n-NRKLLDLIKKKAEYFSTEEIIQRSAPGEQEPQHTD..R--LKYVSRLVARYNLETFLEIKS.---RDRIDI-LEDIDSDTLNDFTFRIEKYMDENAPG-........LADLKTYILIVSTYLAFIVKKPLHPPGMLFVGG.QKIVEK....DN....KFYCPMKN..K..QLRTAFSLCKYCASRD-i..........
A0A166BU60_9EURY/2-148              ..................kaskl-----L--------KIIQEDLKKYPINYLK-NKVTD..ERYIDPLIKKLAEYNSNIYYEIYE.----CEIEDD-YEISNDVVKNIRNDIGYYFDKYAPT-........EFDEKKLTTNLTLYLALIAKKPLHPFSED--KN.DDVFFF....NG....TYYCKGKI..K..YIKDYRSLCRYCSCK--tl.........
A3CUT9_METMJ/6-168                  .......................TKGDLLRIIADETAAYDLRDLEAMNARFERKVAHLP..EDYRDRLLSSVREEIFGAHHRLVLlSRNSGGRELDG--PPAPALSAYCSMVAEACTAKAREK........DPKYLYLKYLLSAFTIFVVEEPAHPVGTPFPGG.QIVDEW....EG....TYLCPVRD..L..ADDVPFALCPYCPAVQS...........
E1RF46_METP4/21-182                 .......................TRGDLGKAIAEAVSGYSPGDLKKIQWNFSGRIRNIN..PLYRSKLERTVNGHLSETWEKIRImNQQGSFSPMKEPL--PEDAKQFWNIAAAECSSGEPE-........KDRIRFLKYLLAGFCIFVMNVPPHPVGMPFPGG.DKVQLI....DG....IYYCPVRE..K..SGDVDSALCPFCPARQT...........
U6EA65_9EURY/15-173                 ......................s-KDELLKILKKEARSIHITEIMKASNFLREDASYMP..PKERDDYIARFTKAFFTRIKDIKD.----DQSNYK-GMVNPEKLSEFLKVQEELSQKSINND........EKCFHRIACVVSTYTAFVKEESIHPVGTRFPGG.FTLKLV....NS....VYLCPVKD..K..QIDTPSALCRFCVSVQD...........
D1YZJ5_METPS/35-197                 ......................k-KCELGEALAFELGRLSILDLQAMSAFLEYEINKLP..SPYRESIHPYFTEQLFGSYFKLMRmHGDGSLKKIPGEIEDQKTFLEYCAMITGGEDGHLE--........ESYYGGYYHLVSCFTIFVMDEPGHPVGMPFPGG.FRVERR....PE....GFYCPIRD..K..EKDVLFSICNFCPAKQS...........
Q2NHX8_METST/2-152                  .....................ky--NTLKEILKEKIREVTLQELYDLSFEFNEDTKYLP..REYKKKYIESVLNVIINRFNSLKN.---------TQENFEGEVTKKEASEINKILTKT----........NNRLTDALNVIVVYATYLKREPIHLPGTEFPGM.QSIYTD....GE....NYYCPIKR..Y..HIDNDKALCRYCVAKET...........
A0A0N8W8N9_9EURY/33-204             .......................TRGELAETIAEEISTYSLYELQVIGGTVKNEIDRLP..SPYRERIRPYFDKQFFGMYHRLLSmHRSGKFFNLGEPISDEETFARFLAAVPAGCFENSGASgte.fsfgEPVRSLFYYLLSAFAMFVLEEPGHPVGTPFPGG.FTVEKR....GE....DYFCPIRD..K..EEDIPFSICNFCPAKQM...........
R9SKF2_9EURY/15-175                 ......................s-KNDILNIIKDEARHLTIYDEMAASSYLQEEGKYIQ..KSYRDEYLDVTIKYFLKRLHRIKN.----DNRDYP-ETVDKKRLKGSLRILKNQYLQQKGNLp......eSNKTPLMYGIISIYTTFILEESIHPLNTPFPAG.EKIILK....DG....TYYCPVKH..N..QSKNPDALCRLCIAKE-m..........
A0A101DP15_9EURY/12-172             .......................TKRDLLKILKKEASRISIRDIMDVTIYLREETKYMS..AREREEFIKRFTKAFFNRMRDVKN.--EKDRKEYN-RPIDTKRLSEFIEFLDEQLKNAKNKP........EKCFQKIARIITIYATFIKEEPIHPVGTRFPGG.LMVKKR....KN....VYYCPVKE..K..QMDTPGALCKFCVSVQD...........
Q2FL19_METHJ/21-192                 .......................NKGELGTIVAEEIQKYSVFELQVIGGRLHLEIERLP..AHYRHKIRSYFKDQIFGAHHILLSrYRSGYFRKCTDQIRDPELFLSYCRMIPDGCMAWDEGMwkn.peiwSPRHRLFYYLIAAYTMFVEDLPGHPVGMPFPGG.QVVEKR....GN....EYYCPIRD..K..EKDVFFSICNFCPARQT...........
K4LFF1_9FIRM/18-173                 ......................n-TQDLFIIIKNEAESLHIENFLNLNKSTNQVFEPGS..IEY---ISNLMSNYNLSNYFEIIR.----KENVNNPEDINPHLIEDFSNRIEIYMDENAPG-........QIDLKQYIRIISTYLAFISKKPLHPLGMIMQGT.EKIIKQ....ND....KYYCPMRR..A..QIKGKLSLCIYCVCRD-i..........
A7I898_METB6/33-193                 .......................TRGDLGKKIAALVLEYSPRDIRQMMTNFGNTIQDIS..MEYRAELEASVTLHLLGTYQDIRLaEQQGSFARMKEQVTAHE--RSYWGMVEGQCRNGPG--........DLRLRFLKFLLAGFAMIVRQEPGHPVGMRFPGG.DRVERI....DG....VYYCPVRE..K..ANDVDAALCPFCPAQQT...........
F0TAZ0_METLA/15-175                 ......................t-RVELLEKLKKEAKNIHIKDIMNACNFLFEEGKYVQ..PSYREKFHNAYLKGFILRIKEVKD.----DKCTIQ-QLVDMDELKKSLKLLEEQEIDLLRNHp......hDPNFSKIYQIISIYTTFVLEEPIHVVGSEFPGG.FKVKFE....NK....TYYCPVKD..K..QKDNPGAVCGFCIAEQD...........
F6D7G3_METPW/41-199                 ......................s-KNELLSVLKKEAYCIHIIDIMMADTFLRADARYVP..ARYRDELLKISTKAFFTRIKDIKD.----DKKHYK-GNVDVNKLKEFLNALKKQRDDAKVNM........ELCFLKIARIISVYTTFIREESIHPVGTPFPGG.FKVRYD....DG....NYLCPVKE..V..QKKNPNALCRFCISKQD...........
A0A126R3V5_9EURY/2-160              ......................k-TRDLLEEIKENIKDYDIK-------VLEEKVKKVD..I---NPISKQVSAYNIENYKEIIS.LNIDEESEEN-IEISDKKIYSIKKEIAKFFDGCSPES........EEIFKKFIESICLYLSLIARKPLHPVGMDFSNG.KTVFKE....EKnnkiNYYCDIKEelK..MRSNEYYTCKYCICKE-v..........
Y666_METKA/2-137                    ..........lrrdawrqarfvh-----------------------------------P..RSYREKILRSLFFALTARINQMRR.---LDPEEYPE--DPIEGYDRFLEIVREYAEDPDYD-........SPLLLLYESLSAAYAIFLRGEPVHPPGTEFPGV.GKVRRT....DD....CYYCPIKE..R..REDQPGSFCTLCPAEQD...........
A0A101IWL6_9EURY/70-232             .......................TKGDLIRLLGTEVKRFSLRDLEMMYTRFEEKTRNLP..RQYRNLLLPKVNEQIFSAQHRLLLlARSGAGDED--ETTLPKAAVSYFGMIEAAAREKAKTN........DPTFLYLKYLLAGFTIFVMEEPAHPVGTPFPGG.QIVDEW....EG....EYLCPVRD..R..ADGVPFALCPFCPARQS...........
A0A101J0M9_9EURY/29-197             ......................t-RSHLARLIADEICRYTSHDLMQIAAGLRHELQNLP..PLYRKAYQQSAHEQIFGTHHRILLmKREGRIDTLPGEIPDPALFTTFCRMVEEACLVPDRSGdv....hmTPMGRLLYYLLSCFLIFVMQESAHPIGTPFPGG.MKVELK....GG....VVCCPVRE..K..EEDVPYALCRFCPAEQS...........
E1RH52_METP4/29-200                 .......................TKGELAEAIASEIIKYSLYELQVIGGKVRQEIDKLP..SPYREKVRPFFQQQLFDVYNRLMSmQRSGGFSRMKGKIDDPALFAEFLDAVPAGCLKDPEHSgtd.fnfgDPIKSLFYYLLCCFTMFVMDEPGHPVGTPFPGG.FIVEKR....AD....GYYCPIRD..K..EEEVPFSICNFCPAKQM...........
K4MED9_9EURY/2-160                  ......................d-STDLLNSLQKEARKISNEDICLARAAVVDSVQDLP..GKYRKAYSSDYFTYLYEAFQELRT.CK----TSDKAEPVDDEEHRDLLTRISQQKDKSNPR-........QRAFLRFVAVVTPYLVFVAKRTIHPPGMIFPGG.LMITSQ....GG....EYYCPVKS..K..QSGVELALCDFCKCRD-s..........
D7E9K9_METEZ/2-160                  ......................d-TSQLFQCLKKNALKISIHDLMKAKAYIEYNNRNLP..EKYQKDYTQNLFEYIFNTLIEIKN.----KNSVDSVEHIDENVFKDLVEKINRLNENYSPE-........QKIFNRLIKIVSLYLVFIAKKPIHPEGMIFPGG.FKITKE....SG....VYYCPVKN..K..QSGIEFALCDFCVCRD-k..........
U6EC76_9EURY/13-172                 ......................s-KNDLLDALKDEANQLHINDFMKTCSFLKKSMKYVH..PHYQEEYIKMYTEGYLKGYRDVKN.----DKNSYE-GKLNCEELFEAVKLLEGQEELMKKEF.......gEDRSFKPYMILSLYTTFILEEPVHPVGTPFPGG.LKVREE....ES....IYYCPVKD..N..NQNNPLAVCGFCIAHQE...........
A3CXE2_METMJ/58-229                 .......................TKGDLGLLLAEEVSRYSLMDLQIIGGRLHAEIIRLP..EPYRKQVHPFITEQLFGAHHQLLAmHRSGRFRSMTEPITDRATFVEFCNMIPDGCFRRDESPeri.pfrnTPRHRAFYYLVSAFTIFVLDRPGHPVGMPFPGG.FRVEEH....NG....SFYCLIRD..R..EKDVPFSICNFCPALQT...........
A5UJ91_METS3/3-149                  .askllneirenlkdypidylkn--------------------------------KVTD..DRYKDPLTKSLAKYNSGVYDEIYE.----KELEND-FKINDGVVQKIKGDINFYFDKYAPN-........DNETKEFTKYISLYLALIVKKPLHPYGND-PKK.DEVYMK....NN....SYYCKGRA..K..FIKDQKSLCRYCICKN-p..........
A6UW08_META3/2-163                  .......................NKMELLDILKKLSNNFGVYELMNVRIFLEKDMAHVP..KEYRTHYINSYIGYYSKLLNNMKTiIPKNNNIGDKDCPIDEEKYNKLMDRIEQLKPEDSK--........GSSFIKLSKIVVPYLVFIEGIPLHPVGMKFPGG.NRVIKK....NN....NYYCPVKN..K..QDN-KYSLCEFCICKD-y..........
R9SM74_9EURY/15-177                 ......................f-KQDLVEILKDKSKTISVFDQMNCTNELWEGLKFVQ..GKHKKDFFETYCKYFILRINDIKD.----DKNDYDSETFDFDEFVKFVVMLENNYYEIGDKDv.....mrSEAFRSIYAIISLYTTFVLEEPIHPVGTKFPGE.LEVEYD....DG....VYYCPVKE..N..NVDNPKAICQFCIAEQ-l..........
A0A166E6F3_9EURY/21-180             .....................ea--MDLFEILKEESKKVSINTIMGMSTFLREDFKYIQ..NQYKEHYTESILSQLL-RINEIKN.----DNSYY-LNTIDKKKFNIAIKSIMNFLNCDNLYD.......gEEKFNIISILVTFYSVFLIQKPIHPVGTTFPGEnLKIKEI....ND....EYFCPVKS..K..QIKNPNSLCSFCICKS-d..........
A0A166ET54_9EURY/15-173             ......................s-KNTLRDILKNIGKTISIMDLMLATTILREEGKYVQ..KGYREEYLEIYVKFFIMRVKDINE.----DKTDYK-DNIDKKELLESIELLKNQNQENDDRL........NTKFPIIYTIISLYTTYILEEPIHPVGTPFPGN.LKVTAE....DN....TYYCPVKE..N..NKNNPSAVCKFCIAEQS...........
A0A126QYH6_9EURY/16-174             ......................s-KKSLLKVLKEHAGTISVFDLMSVSAEMTEDTKYVQ..EEYREKTNEVYVKYFLGRIKDIRD.----DENNYE-GHIDKKEFIDSIATLKSYQKEESISS........KTKFPLIYAIVSLYTTYILEEPIHPVGTPFPGS.LKVEEK....DG....VFYCPVKE..A..NLESPNAVCRMCLAEQ-l..........
B8GKS1_METPE/34-196                 .......................TRGELGTALAAIVLLYTPADIRQMQRNFKTKIRDID..EDYREPLYLKVTEHLLGTYQQIRLlSQQGAFSRMDIPVSPEN--SRYWAMVAAACSARAEEK........GPRLAFLNYLLAGFCIFVLDEPAHPVGTPFPGG.DTVECE....DG....IYYCPVRE..K..SSEIDAGFCGFCPALQT...........
A0A117LRJ2_9EURY/77-239             .......................TKGDLLRIIAGEVAAFDLHDLEAMNARFERKVSHLP..EGYRDRLLESVREEIFSAHHRLLLlSRNGGGQRMDE-PPDPA-LDAYCSMVAEACTAKAREK........DPRDLYLKYLLSAFTIFVQEEPAHPVGTPFPGG.QIVDEW....EG....AYLCPARD..M..ADDVPYALCPYCPAAQS...........
D3E3I4_METRM/20-177                 ....................skl----FLEVLKEHSGTISVYDLMSVTAELREDTKYVQ..DKYREETNAVYVKYFLGRIKNIRD.----DNNQYD-GSIDKDDFIESVATLKSYQEGESKTS........KTKFPLIYAIVSLYTTYILEEPIHPVGTPFPGS.LKVTQK....NG....VFYCPVKE..A..NLESPNAVCKMCIAEQ-l..........
E1RKK9_METP4/41-212                 .......................TKGELGSILAAELADYNNTDLQVIGGWLYAEICRLP..SPYREQVSPYLKDWLFGAYHKLLLyQRTARFSTMSESIRDRETFLAFCRMLPEGCLQRDESTqkl.pfryTLKHRCFYYIVSAFTIFVLDNPGHPVGMPFPGG.FKVEER....DG....RFLCPIRD..H..EKDLPFSICNFCPAIQN...........
L0HI22_METFS/76-238                 .......................TRGELGERIAGLVLLYSPSDIQQMKRNFETKVRDLD..PAYRERLTAKITEYLLGTCQRIRLdNQQGVYKTLKQPVLPAQ--KNYWEMVARQCGDEEGGD........LPVIRFLKYLLAGYSMLVLEEPGHAVGTPFPGG.DEVEYT....GG....VYYCPVRE..K..ASDVDAALCPFCPAKQT...........
F0TAZ1_METLA/15-173                 ......................s-RNELKDVVKSEAGNIHIKDIMLAASFLRDDAQYMP..KSYRDDYIERFSKSFFSRVKEIKD.----DKKNYP-GDVNRKDLVEFLELLDEQSKNARTQQ........EKCFVKIARIISTYTTFVCQEPIHPVGTKFPGG.FVLHIE....NG....NYMCPVKQ..R..QMKNPSALCKFCVSVQD...........
B8GKT1_METPE/36-208                 .......................TRGELGALIAEVALSYSVFELQVIGGHLRREVAALP..SPYREAIDPYFTAQIFGAHHHLLLmHRSGAFLRMQTPIADPTLFADFLAMIPASCLRSDDERpgvsghlrTPRHRLFYYLMTGFMIFVLGRPGHPVGMPFPGG.FFVKEE....GR....RFLCPIRD..K..EKDLPFSICNFCPAEQ-i..........
D7DU54_METV3/2-156                  .....................di--KTLLTDLKDLSFEISIYDFINAKSELEKELKYLP..EEYKQCYIDDFFTFFPKIIKEIKS.---LDLNSIETFEINDEDLKKLIDRLEVLSNK-----........ERKSYKIYRIVIPYLVFFAKKPLHALTTKFPGK.KSIVSK....KG....VYYCPIKE..A..QKN-DLSICEFCICKD-i..........
B8GII9_METPE/31-202                 .......................TKGELGVILGEEISRYSMQDLQVIGGRFVADMAGLP..KEFHNELRPRLAEGLFGAHHQIVTlYRSGKFLSMAAPIAHPETFRRFCRMIPYGCLHWDEHVeqt.pfpyTERHRLFYYLISAFSMFVMDRPGHPVGTPFPGG.SHVEEQ....NG....TLYCPVRD..R..EKEVSFSLCNYCPALQT...........
A0A125RC62_9EURY/22-179             ....................cds----VLEILKKYSSTISVFDLMAVNAEMIEESKYVQ..DSYKMKSHGVYAKYFLGRIKDISS.----DETHYD-SDIDKEEFIDAVATLKSYQDNESIKS........KSKFPLIYGIVSIYTTFILNEPIHPVGTPFPGS.LYVEEH....DG....VYYCPVKD..A..NLESPNAVCKMCIAEQ-l..........
H1YYU4_9EURY/19-191                 ......................m-RGALAEYLAVELLKFSMYDLQMIGARVRYDIEILP..EIYRKKLRPYAEEWFFGRYHQLITkYRDGDFSKYSGPVHDIDTYRNFCMMIPEGCFKSDVNLpsfipddrYPSFSLFYYLLNAYAMFVLEEPGHPVGTPFPGG.AVVRKT....AG....KYYCPIRE..K..EEEIPNSICNFCPALQD...........
D3E0U5_METRM/2-158                  ............kssvlleeike--------------NIQNYDIDHIKENL-------K..KEDINPISKQVSEFNLKNYDEIME.---TKISEEDDFEISDEMIYSMKNEIDLFFKGCSPES........EDSFKKFIESICLYLSLIAKKPLHPVGMDFKNG.NTVHEEiedgNT....VYYCDLKE..YfgKQEKDYYTCKFCVCK--tv.........
A0A166EXB2_9EURY/15-177             ......................y-RNDILKILKKWAKKISIFDIMESTYRFREACKYVR..DEYKGHFDDIYVKNFYMRVKDIIN.----DNNGYD-GFVNKKKFLKSIDFFQDQNKERTGEDie....ekYNNQRLIYYLICIYTTYVLNEPIHHEGSVFPGH.TKVRYD....NG....VYYCPVKS..N..NSNNPKAVCRYCIAVQ-g..........
A0A0Q1FDF7_9EURY/33-204             ......................t-QAALGEAIAAEIIRYSMYDLQVIGGNMKRETDRLP..SPYREKVRPYFEKQLFGTYHRLLSmHRSGALARRTAPITDRETFLGYLRMVPEGCFGDTDSSgtd.fyfgDPVRSLFYYLLAGFAMFVLDEPGHPVGTPFPGG.FVVEKR....GR....EYLCPIRD..K..EEEVPFSICNFCPAKQM...........
B8GG14_METPE/6-153                  ................lllriqs-------------------DLEEISGYTSRIAVEIPlrSEEPSTIISRLAVYNYQTYLEIRS.-LSGIAP---DFEIDEKRLGQMYSVLAHYLDRYAPG-........NEDLHCYVTAISIYLTFIAHKPLHPPG-SFSEE.IQIVRR....GS....LYYCSGRR..K..FIRDNPSLCRFCVCQ--pa.........
Y811_METTH/3-152                    .....................gs--DALIMALRNMAATLGVYDLMEVRVFLERSCRFVQ..ERYRAIYVDAYMSMVVDSVLDLKA.----GFSGTPEMDDARYSLRDALKRLD----------........EINAPTIVGLTVLYRTYVKGEPLHPPGTPFPGG.FEVEKK....DG....VHYCPVKD..K..QSDNPEALCDICIARQS...........
D5VU42_METIM/2-152                  ......................k-ATELLKKLKEEAKNFSIYDIAKVRAFLERDAKYLP..KNYREKYVNKMLEHFLKSLKEVKE.----YKLKED-YEIDEKKLKALLDRIENSGYD-----........-ETFIRLSKIVCPFLVFIAKKPIHPLDLEFPGG.LKIIKK....GD....KYYCPVKE..K..QKN-QFSLCPFCICQ--p..........
L0HGV6_METFS/29-200                 .......................TRGELGEILASEAGKYSLFDLQIIGGRLNAEIEKLP..SPYREAVAPYFRDQLFSAHHRLLSmYRSGAFCRLTGPIRDRERFEAFCTMLPSGLYAWNDAGern.pyfqNPKNRFFYYLVAAFTMFVLEEPGHPVGMPFPGG.FTVEQR....GS....DYYCLIRD..K..EKDVFYSICNFCPARQ-a..........
A5UK44_METS3/20-180                 .......................TKNELLKLLKKYCKIISPYDLMLATARMREEGKYVQ..ANYREKYLEVYVKYFIMRVKEILD.-----NNNYLDEAIDKESFDESFNLLKYQFEKERNYSi......eEDKFPLIYIITALYTTFILEEPIHPVGTEFPGS.LKVEEK....NG....EFYCPVKD..K..QKDNENAICNLCLAEQT...........
J0S9P9_9EURY/35-197                 ......................t-KLELLGAISDAAARFSVTDLEAMMKNFEEKTRDLD..PAYRRLLLPRIHASIFGSYHALMLlCTDDPALEDG-P--VRPSLGAYAAMVQEACRRRAQAE.......nPLELYFLKYLLAAFTMYVLEEPAHPVGTPFPGG.LAVYRE....GD....SYYCPVRD..K..SDDIPFSLCPFCPARQD...........
A7IAC9_METB6/28-199                 .......................TKQDLGVHLARAAGEYTLADLQVIGGRLFAEVDALP..EPYRSRVRPYFHEQIFGAHHRLLLmYRSGVFRQDQDPIRDRETFDKFCAMIPDGCFTWDEQAert.pfrySPRHRLFYYLMAAFTMFVLDRPGHPVGMPFPGG.FTVEER....NG....NCYCLIRD..R..EKEVFFSICNFCPAKQN...........
A2STY9_METLZ/48-217                 ..................snqaa-----AEIIGRALSAYTVFDLQYIGGYLKCEAERLP..DPYRRLYRPYCMD-LFDQYHAFMQdFRPGIVC--HGPLPDLDLWKKYWTGVPEYCFQDAVSSqsprpvqnHPLSKFFYRLVFAYVMFVKGGCGHPVGMPFPGG.FRIRQA....GD....IVYCPIRD..R..EKDLPQALCNYCPAKQD...........
H1Z2H4_9EURY/18-178                 .......................TRGELGRAIAAIVNGYSTLDLRRMQWNFSGSVKGIE..PSYKKKLEKMITGHLHETWENIRLmNQQGSFSQMKD--LLPENNREFWEMVALKCSDKDG--........STRIRFLKFLLAGFCIFVKKIPPHPVGMPFPGG.DSVQFI....EG....IYYCPVRE..K..ANDVDSALCPFCPALQT...........
A0A125RCQ9_9EURY/2-148              kaskllkiirenlkdypieylrn--------------------------------KVTD..ERYRDPLTKQLAKYNSSVYDDIYS.----VEISED-FEINDDIIRNIRSDIGFYFDRYSGG-........DDENKRFTENISLYLALIAKRPLHPYSED--KK.DDVYYF....NG....DYYCKGRM..K..YIHDKKSLCRYCVCK--tv.........
A3CTH3_METMJ/19-180                 .......................TQRELAKILYHAVSGYSLFDLQEMRGRVERDLRSVP..AGYRRRLYPSVMEQIFETHHTLIVaGRRGD--PGDGERLLPGEFQDFCDMVEKTCLREDEG-........ERHLELLYFLLAAFNIFVLDRPAHPVGTPFPGG.FEVEVR....NG....EYLCPVRE..K..ADDVENALCPYCPAKQS...........
#=GC seq_cons                       ........................+t-LhphltctstphSlhDl.thpshhcpchchls..ppYRcchhphhhchhhtph+clhs.....shpphp...h-pcphpchhshlppttppts.p.........psphphhhhlluhYshFlhccPlHPVGpsFPGG.hpVcpc....su....pYYCPl+-..+..pp-sshulCpaCsAcQ............
//
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