GenomeNet

Database: Pfam
Entry: DUF2121
LinkDB: DUF2121
Original site: DUF2121 
#=GF ID   DUF2121
#=GF AC   PF09894.7
#=GF DE   Uncharacterized protein conserved in archaea (DUF2121)
#=GF AU   COGs, Finn RD, Sammut SJ
#=GF SE   COGs (COG4079)
#=GF GA   26.80 26.80;
#=GF TC   197.70 197.70;
#=GF NC   26.70 26.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR016754;
#=GF CC   This domain, found in various hypothetical archaeal proteins,
#=GF CC   has no known function.
#=GF SQ   23
#=GS Q8TNH4_METAC/1-191      AC Q8TNH4.1
#=GS A0A0E3WRJ9_9EURY/1-192  AC A0A0E3WRJ9.1
#=GS R9SLQ2_9EURY/1-199      AC R9SLQ2.1
#=GS F0T5U9_METLA/1-198      AC F0T5U9.1
#=GS A5UN99_METS3/1-198      AC A5UN99.1
#=GS A0B8J8_METTP/1-186      AC A0B8J8.1
#=GS U6EDG2_9EURY/8-205      AC U6EDG2.1
#=GS Q8PT14_METMA/1-192      AC Q8PT14.1
#=GS O26846_METTH/1-198      AC O26846.1
#=GS D5VTH9_METIM/1-193      AC D5VTH9.1
#=GS A0A0E3NWI8_9EURY/1-192  AC A0A0E3NWI8.1
#=GS F6D487_METPW/1-198      AC F6D487.1
#=GS A3CUY9_METMJ/1-193      AC A3CUY9.1
#=GS F4BV53_METCG/1-188      AC F4BV53.1
#=GS E3GZ98_METFV/1-198      AC E3GZ98.1
#=GS Q466H3_METBF/1-192      AC Q466H3.1
#=GS G7WN05_METH6/1-187      AC G7WN05.1
#=GS Q8TYL1_METKA/1-201      AC Q8TYL1.1
#=GS D7DVA7_METV3/1-193      AC D7DVA7.1
#=GS D3E4F2_METRM/1-198      AC D3E4F2.1
#=GS A6UW86_META3/1-192      AC A6UW86.1
#=GS Y548_METJA/1-194        AC Q57968.1
#=GS Q6M196_METMP/1-192      AC Q6M196.1
Q8TNH4_METAC/1-191                 MTLVIAFIGKNGAVMAGDMREITFEGEKPDREKLEKELYNGAIVTDEELARKAEEAGVK...ITVTDCKNKVSER.NGILVGEVSSVERGIVKKRRLYASAGSYAIAELRDSELTLTSQGKGSnFIAFGNEFTKQVANKCFKDNWT..KKSKLQDAVKVLMLCMETAAKKTASVSKQFVIVQTSS.NVD----..-VLKLVEKD--g....
A0A0E3WRJ9_9EURY/1-192             MTLVIAFIGKNGAVMAGDLREITFDGEKPDMEKLEKELYSGTIVTDEELTKKAEEFGVK...IMVTDCKSKVSER.NGILVGEVSSVEGSAVKKRRLYASAGNYAIAELRDSELTMTSQGKGSnFIAFGNEFTKQIANKCFTDNWT..KKSKLQDAVKILMLCMETAARETASVSKQFVIMQTAS.NVD----..-VLKVVEKD--rk...
R9SLQ2_9EURY/1-199                 MSIIIAYIGRKGCVMASDKRRIAYFGDKDNREKLEEELYSGNIRNDEELYKEAAKLGID...LKISDDAKKIKSI.GNAVMGEVSSKTTREVRRRRIYGTTNGYQIIELIGSELKNKETGSSG.IIIFGNKIAKQMANSLIKQRWK..SSISLKYTGDIFEEIIKEIAEKTPSVGKNVDVIIGKDsKLTKTTAqkYLDETETRDI-k....
F0T5U9_METLA/1-198                 MSLIVTYIGSKGCIMAGDKRRIGFYGSPEARETLEDELYAGKIKTEEDLIKKAEEQGIN...LKISDDTTKIREM.DNVLVGEVISRATHETKRKRIYAISGAYSMVELTGSNIDTVKSGGRS.IIVYGNKYTQELAEKTIKKYWK..PKMKFVDVERIMELVMSEVSENTPSVSKSFDLMIKYN.SMDQKLAkeVIRTTVLEDV-k....
A5UN99_METS3/1-198                 MSLIIAYIGKKGCVMASDKRRIGYFGNKEQLNALESELYSGKIKTDEEFKKKADEYGIS...IKLTEDATKITTV.GNCVRGEVTTKKVFETYRKRIYGTTMGYQIVELSGSETVSREAGEKA.IIVFGNKFAKQEAEKLINKKWK..PSLSLKYMGDIFEEILTEISRKTPTIGNTFDVLIKQP.KFNKSEAqrHLNVSIDKDIK.....
A0B8J8_METTP/1-186                 MSLVIAFSGRE-AVIAGDRRSIAFAGDCRL---LEEELYSGRIHDDVELLRRAGELSAT...IYISDGREKVWRD.GDVLVGEVTEVSASSSKRRRVYVTSGAYLIVDVVDGNARISGRGGAS.LIILGNRHTRDAAGKALQGLGK..------ISADAIARVMDEVSAGTATMSREHTLLKITA.HHKDPAS..ILMQTFSRDCE.....
U6EDG2_9EURY/8-205                 MSLIITYVGSKGCVMAGDKRSIGFLGDKEQREVLEEEMYSGKIKTTEELLQRAEQLDIN...LKITDDVEKVRKI.GDVLVGEVKLRTTTETKRKRIYGTSGGYHEVELSGSQIKNAKSGQSS.IVVFGNKFTKEIANKHLQKYWK..SQTSIKEIAKIFQRIMEDVAQSTPSVSPQFDIYTVHP.QLNHKQAmeILRTTIVKDVK.....
Q8PT14_METMA/1-192                 MTLVIAFIGKNGAVMAGDMREITFEGEKPDREKLEKELYSGSIVTDEEMQKKAEEFGVK...ITVADCKEKVSER.NGVLVGEVSSAEGGVVKKRRLYASAGNFAIAELINTEMTLTSQGKGSnFIAFGNEFTKQVANKCFKDNWT..KKSNLQDAVKILILCMETVARKTASVSKQFMIVQTAS.NAD----..-VLKVVEKD--rn...
O26846_METTH/1-198                 MSLIITYISSKGCVIAGDKRRIAYFGDKSSREVLEEELYTGKIKSDEELQRRASELGVN...IKVTDDTCKVRSL.GDVVVGEISQKTPFETRRRRIYATTGAYQIIELTGSRITSMEKGDTA.IIVFGNKIAKEITNRFLKKRWK..TKTSLKDVADLFRELMDHVSSQTPSVGSEYDLFIKSP.SLDKKSAhrLLSDTIVRDV-r....
D5VTH9_METIM/1-193                 MSLILCYFGNNGAIILGDRREMFFRGNEEKRKELEELLYSGEIKSEEELRKKAEELGVK...IIIEDKRRKVWKI.KNVVVGEVRSLGL-DAKRRRVYATKRKAKILEILNDQIIGEKNLEGFsIIIFSNKFIKEEINKYLKEYYRvlPMKRIDEVGEIFKEIYKKVS-WHPTLSEEFDVEKTDK.EEE----..DFEEVIEEDVK.....
A0A0E3NWI8_9EURY/1-192             MSLVIAFIGKNGAVMAGDMREITFEGEKENREKLEKDLYSGAIVSDAELEKKAEELGVK...ITVRDDKNKLEER.DGVLVGEVSSVEGGVVRKRRLYVSAGNYAIAEIEGSEIRVTAQGKGSnFIAFGNDTTKAIANKCFKDNWK..-KGNLQLAVKIIMLAMETAARKTASVSKKYMLLQTAS.NVD----..-VSGVVEKD--lse..
F6D487_METPW/1-198                 MSLIITYIGSKGCVMIADKRRIGFFGEEKTREKLEEELYSGAIKTDEELLKKASSLGIT...LKITDDAEKIREI.GDIVVGEVRFKTPFETKRKRIYGTTGAYNVVELLGSEIKRIKTGESS.IVVFGNKVTKEIANKYIQNHWK..KKTNLKDIGEIFKAAMEEVAAKTPSVSQKYDLFIKHA.DIDKKEAkeLLRTTIITDVK.....
A3CUY9_METMJ/1-193                 MTLVIAFIGKQGAVMAGDMREIAFGGDDSSIEDLERELYGGSIASDSDLAKRADEIGVT...IQLRDDKTKVSQR.DGVLVGEVTETEGAKTSRKRLYATKGSYVIAEIVDSRLRVMQKGQASnFVVLGNDTTKEVANQCIQGMWE..-GGTIQDALRLIMLTMQIAASVTASVSRTFVLVHTDI.AADV---..--PAAIAN---dsrke
F4BV53_METCG/1-188                 MSLVVALTKSKEAVIGGDRRSITFLGSWPE---LEEELYCGRISDDEALLAKAMEIGAI...LQVTDGRDKVWRR.GDLLVGEVTEITPQLERRRRIYLAPGSQLQVDITGKEVRIRDRGAMG.CIIYGNRFTQQIAVSIV-----..VQADGRVDEALIRKIFQEAAERTASVSQEHVILKSER.MLSNPQK..ALEKALEEDC-q....
E3GZ98_METFV/1-198                 MSLILAYVGKKGCVIAGDKRKIAYFGDKSSRKILEEKLYTGKIKTLDELFEEAKKLGVS...INITDNAKKVREK.GHVAIGEVGIKATHSAKRRRLYATTNCYEIIELEGSKIVKRKKGNSA.LIVFGNRITKKISNEILKKEFN..PKMSLQEIANLFKKIIKKASELTPTINKSCDIVIKNP.ILNKEMAekILEMSISEDIK.....
Q466H3_METBF/1-192                 MTLVIAFIGKNGAVMTGDLREITFEGEKPNREKLEKELYNGTIVTDDELAKKARAFGVG...ITVTDCKSKISER.EGILIGEVSSIEGGVTKKRRLYASAGNYAIAELKDSKITLISHAKGSnLIILGNDFTKQVANKCFKDNWT..KKSTFQDAIKILMLCMETAARKTASVSKQFFLIQTTS.NVD----..-VLKIVEKD--rn...
G7WN05_METH6/1-187                 MSLVVGFAGKKRAIVAGDKRSIAFFGRAEE---LEEELYGGEIRSREDLQRRCEELGSK...VAIADGREKVWDR.GGVLAGEVTEISAERERRRRIYLVPGGYLLVEVDGKRAEISKRGAST.LIILGNRFTRDFAFKRLGSGRP..------PDEASIRALFEEAGRATASVSPDYTVLTSSS.IHRDPEA..ALLRALREDCE.....
Q8TYL1_METKA/1-201                 MTLVLAYAGTDGALVAGDRRTLVARMDEEKMRKVEEKLYSGEIRTEEELESFLKDLDVEdgyFEFHDDRKKVWKVnDEVVAGEVGVRSAKGVRRRRVYATPGAHAIVELEGEKVLSKNFGGPA.LIVEGPKVVKELVIEFVNSELG..GKPDLESLRNALDDLFEYVSSGTILVSSEYDAYEVKG.KAD-PLAraRLQKAIDEDIE.....
D7DVA7_METV3/1-193                 MSVIIGYYGNNGSAIAGDKRNILFRGSEANREKLESLLYNGKLKNDKELKEKAEEYDVK...VHITDSQDKIKKL.DGCLMGEVKTISN-QSKRKRMYLSKNNCALVEIIDDDMTKKEIKKGSgIIIFGNKHLKQLVQAELQKNVNivKSGDILKIEKLFKDILSNID--TPSSSNDVDSYSNFK.YEN----..-LEKVISQE--lsnl.
D3E4F2_METRM/1-198                 MSLIIAYVGKKGCVMAADKRRIAYFGLKEQREILEQEIYSGEIHNDEELYARAEELDVN...LKVTDNACKVKSI.ENVAIGEVSSRGTMETKRKRIYGTSNGFKIIELSGSHVLNSKRGVSS.IIVFGNKVTKSLANKMIQERWK..PSFSLKYMGEIFGEILKDIAEITPSVGKDYDVIIEKN.NLAKSQVqdYIDEVAERDV-k....
A6UW86_META3/1-192                 MSIIVGYYGANGAVVGGDKRNIIFRGNAEQREELEKLLYSGNIKTDEEFKKIADEYGIK...VYIEDKQLKVREV.NGVLVGEVKSIGT-DSQRRRMYLSTGNCAIIDILNDTITKKSSNVGHgLILFGNRYLKEIVHNELKKDAPnfKNMPIEKVKNIIENAIKRCD--GPTVSEEIILLHTKD.KHN----..NFKELIKKDI-n....
Y548_METJA/1-194                   MSLIICYYGKNGAVIGGDRRQIFFRGSEENRKILEEKLYSGEIKSEEELYKLAEKLNIK...IIIEDDREKVRKIsDSVVCGEVRSLGI-DAKRRRVYATKGKCAIVDILNDTVTNQTIKEGFgIVVLGNRFLKKKAEEELKRTAKlfPMMPIQQIEDAIKEIFEKLK-WHPTVSKEYDIYSVNK.YEK----..NFEEVIKKDIE.....
Q6M196_METMP/1-192                 MSVVIGYYGKNGAVIAGDKRNLLFNGIESNRAKLEEVLYSGEIKNDEELFKKASEFEVT...VHINDTREKVKSL.GNLLSGEVVSIGK-DSKRRRMYLTKEKCAIIDIENDQITNKSVKTGSgIVVFGNRYVKHFVESEIKKHVQklLKMSAREIRDLFEKILKNIE--NATLSDTFEYYVVEA.GEP----..EFEKAVNKDL-d....
#=GC seq_cons                      MSLlIuYlG+pGAVhAGD+RcIsFhGccpsREpLEcELYSGcI+oDEELh++A-ElGlp...lploDsppKVpch.ssVLlGEVsohsstpsKRRRlYuosGsYtIlElpsoclptpppGpuo.lIlFGN+aTKplAs+tlpcpap...phslpcstclhcplhccluptTsSVScpaslhpsps.phc.......lpcslp+Dh......
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