GenomeNet

Database: Pfam
Entry: DUF2121
LinkDB: DUF2121
Original site: DUF2121 
#=GF ID   DUF2121
#=GF AC   PF09894.4
#=GF DE   Uncharacterized protein conserved in archaea (DUF2121)
#=GF AU   COGs, Finn RD, Sammut SJ
#=GF SE   COGs (COG4079)
#=GF GA   26.20 26.20;
#=GF TC   141.40 141.20;
#=GF NC   26.10 26.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR016754;
#=GF CC   This domain, found in various hypothetical archaeal proteins,
#=GF CC   has no known function.
#=GF SQ   34
#=GS F8AM46_METOI/1-193  AC F8AM46.1
#=GS E3GZ98_METFV/1-199  AC E3GZ98.1
#=GS Q466H3_METBF/1-193  AC Q466H3.1
#=GS G7WN05_METH6/1-188  AC G7WN05.1
#=GS D3S7K4_METSF/1-195  AC D3S7K4.1
#=GS Q8TYL1_METKA/1-202  AC Q8TYL1.1
#=GS Q8TNH4_METAC/1-192  AC Q8TNH4.1
#=GS A0B8J8_METTP/1-187  AC A0B8J8.1
#=GS F6D487_METSW/1-202  AC F6D487.1
#=GS D3E4F2_METRM/1-199  AC D3E4F2.1
#=GS D2ZQJ0_METSM/1-199  AC D2ZQJ0.1
#=GS A9A8S0_METM6/1-193  AC A9A8S0.1
#=GS D9PWZ2_METTM/1-199  AC D9PWZ2.1
#=GS B9AE10_METSM/1-199  AC B9AE10.1
#=GS Q6M196_METMP/1-193  AC Q6M196.1
#=GS C7P7T0_METFA/1-195  AC C7P7T0.1
#=GS A3CUY9_METMJ/1-192  AC A3CUY9.1
#=GS G0H0U9_METMI/1-193  AC G0H0U9.1
#=GS F0T5U9_METSL/1-199  AC F0T5U9.1
#=GS A4G0H6_METM5/1-193  AC A4G0H6.1
#=GS A5UN99_METS3/1-199  AC A5UN99.1
#=GS Q8PT14_METMA/1-193  AC Q8PT14.1
#=GS A6VI09_METM7/1-193  AC A6VI09.1
#=GS F6BAJ8_METIK/1-194  AC F6BAJ8.1
#=GS Y548_METJA/1-195    AC Q57968.1
#=GS D7DVA7_METV3/1-192  AC D7DVA7.1
#=GS F4BV53_METCG/1-189  AC F4BV53.1
#=GS C9RGV7_METVM/1-195  AC C9RGV7.1
#=GS O26846_METTH/1-199  AC O26846.1
#=GS G6FGN3_9EURY/1-183  AC G6FGN3.1
#=GS A6UW86_META3/1-193  AC A6UW86.1
#=GS H1KXB3_9EURY/1-194  AC H1KXB3.1
#=GS D5VTH9_METIM/1-194  AC D5VTH9.1
#=GS A6URH6_METVS/1-193  AC A6URH6.1
F8AM46_METOI/1-193             MSIVIGYYGNNGAVVAGDRRNIMFRGNPEKRAELEKDLYCGKIKNEEELKNRAEELGVK...IFIEDERTKVKKIGD.VLVGEVKSI-GADSKRRKMYLTKGNCAIVDILNDTITNKSIKNGSSIIIFGNKYLKDIVQKELKKYMNnfGKMDILDVKNTIENALKKC--DGPTLSPELDILHTNKKVFNLEE......IIEKDLND..............
E3GZ98_METFV/1-199             MSLILAYVGKKGCVIAGDKRKIAYFGDKSSRKILEEKLYTGKIKTLDELFEEAKKLGVS...INITDNAKKVREKGH.VAIGEVGIKATHSAKRRRLYATTNCYEIIELEGSKIVKRKKGNSA-LIVFGNRITKKISNEILKKEFN..PKMSLQEIANLFKKIIKKASELTPTINKSCDIVIKNPILNKEMAekilemSISEDIK-n.............
Q466H3_METBF/1-193             MTLVIAFIGKNGAVMTGDLREITFEGEKPNREKLEKELYNGTIVTDDELAKKARAFGVG...ITVTDCKSKISEREG.ILIGEVSSIEGGVTKKRRLYASAGNYAIAELKDSKITLISHAKGSNLIILGNDFTKQVANKCFKDNWT..KKSTFQDAIKILMLCMETAARKTASVSKQFFLIQTTSNVDVLKI......-VEKDRN-n.............
G7WN05_METH6/1-188             MSLVVGFAGKKRAIVAGDKRSIAFFGR---AEELEEELYGGEIRSREDLQRRCEELGSK...VAIADGREKVWDRGG.VLAGEVTEISAERERRRRIYLVPGGYLLVEVDGKRAEISKRGAST-LIILGNRFTRDFAFKRLGSGRP..--PD----EASIRALFEEAGRATASVSPDYTVLTSSSIHRDPEAal..lrALREDCE-e.............
D3S7K4_METSF/1-195             MSLIICYYGKNGAVIGGDRRQIFFRGEEQKRKILEEKLYSGEITSEDELYNLARELNIK...IIIEDDREKVRKISDsVVVGEVRSL-GIDARRRRVYATKGKCAIIDILNDTVTNQMIKEGFGVVVLGNRFLKKKAEEELKRTAKlfPMMPLQQIEDAIKEIFEKL-KWHPTISKEYDIYSVNKYEKDFEE......VIKKDIE-s.............
Q8TYL1_METKA/1-202             MTLVLAYAGTDGALVAGDRRTLVARMDEEKMRKVEEKLYSGEIRTEEELESFLKDLDVEdgyFEFHDDRKKVWKVNDeVVAGEVGVRSAKGVRRRRVYATPGAHAIVELEGEKVLSKNFGGPA-LIVEGPKVVKELVIEFVNSELG..GKPDLESLRNALDDLFEYVSSGTILVSSEYDAYEVKGKADPLARar.lqkAIDEDIE-r.............
Q8TNH4_METAC/1-192             MTLVIAFIGKNGAVMAGDMREITFEGEKPDREKLEKELYNGAIVTDEELARKAEEAGVK...ITVTDCKNKVSERNG.ILVGEVSSVERGIVKKRRLYASAGSYAIAELRDSELTLTSQGKGSNFIAFGNEFTKQVANKCFKDNWT..KKSKLQDAVKVLMLCMETAAKKTASVSKQFVIVQTSSNVDVLKL......-VEKD---gg............
A0B8J8_METTP/1-187             MSLVIAFSGRE-AVIAGDRRSIAFAGD---CRLLEEELYSGRIHDDVELLRRAGELSAT...IYISDGREKVWRDGD.VLVGEVTEVSASSSKRRRVYVTSGAYLIVDVVDGNARISGRGGAS-LIILGNRHTRDAAGKALQGLG-..-----KISADAIARVMDEVSAGTATMSREHTLLKITAHHKDPASil..mqTFSRDCE-r.............
F6D487_METSW/1-202             MSLIITYIGSKGCVMIADKRRIGFFGEEKTREKLEEELYSGAIKTDEELLKKASSLGIT...LKITDDAEKIREIGD.IVVGEVRFKTPFETKRKRIYGTTGAYNVVELLGSEIKRIKTGESS-IVVFGNKVTKEIANKYIQNHWK..KKTNLKDIGEIFKAAMEEVAAKTPSVSQKYDLFIKHADIDKKEAkellrtTIITD---vkdlkk........
D3E4F2_METRM/1-199             MSLIIAYVGKKGCVMAADKRRIAYFGLKEQREILEQEIYSGEIHNDEELYARAEELDVN...LKVTDNACKVKSIEN.VAIGEVSSRGTMETKRKRIYGTSNGFKIIELSGSHVLNSKRGVSS-IIVFGNKVTKSLANKMIQERWK..PSFSLKYMGEIFGEILKDIAEITPSVGKDYDVIIEKNNLAKSQV......--------qdyidevaerdvkv
D2ZQJ0_METSM/1-199             MSLIIAYIGKKGCVMVSDKRRIGYFGNKEQLNALESELYSGKIKTDEEFKKKADEYGIS...IKLTEDATKITTVGN.CVRGEVTTKKVFETYRKRIYGTTMGYQIVELSGSETVSREAGEKA-IIVFGNKFAKQEAEKLINKKWK..PSLSLKYMGDIFEEILTEISRKTPTIGNTFDVLIKQPKFNKSEAqrhlnvSIDKDIK-v.............
A9A8S0_METM6/1-193             MSVIIGYYGKNGAVIAGDRRNLLFNGIESNRKKLEELLYSGKIRTDEELMKKASEFDVN...VYINDSEEKVRSLGT.LLCGEVKSI-GKDSKRRRMYLSREKCAVIDIENDRITNKSVKTGSGIVVFGNKYIKNLVESEIKKYIKniLKMSAEEIKNLFVKILENT--KNATLSGNFEYHFVETYENNFEK......VIEDDLN-e.............
D9PWZ2_METTM/1-199             MSLIITYISTRGCVIAGDKRRIAYFGDKSKREKLEEELYSGKIKSDDELHRRASELGVS...IKVTDDTAKVRSLGD.VVVGEISQKTPFETKRRRIYATTGAYQIIDLTGSRITSMEKGETA-IIVFGNKVAKELTNRFLKKRWK..TKTTLKEVENLFRELMDYVSSRTPSVGSKYDIFMKSPSLDKRSAhkllsdTIVRDV--rl............
B9AE10_METSM/1-199             MSLIIAYIGKKGCVMASDKRRIGYFGNKEQLNALESELYSGKIKTDEEFKKKADEYGIS...IKLTEDATKITTVGN.CVRGEVTTKKVFETYRKRIYGTTMGYQIVELSGSETVSREAGEKA-IIVFGNKFAKQEAEKLINKKWK..PSLSLKYMGDIFEEILTEISRKTPTIGNTFDVLIKQPKFNKSEAqrhlnvSIDKDIK-v.............
Q6M196_METMP/1-193             MSVVIGYYGKNGAVIAGDKRNLLFNGIESNRAKLEEVLYSGEIKNDEELFKKASEFEVT...VHINDTREKVKSLGN.LLSGEVVSI-GKDSKRRRMYLTKEKCAIIDIENDQITNKSVKTGSGIVVFGNRYVKHFVESEIKKHVQklLKMSAREIRDLFEKILKNI--ENATLSDTFEYYVVEAGEPEFEK......AVNKDLD-d.............
C7P7T0_METFA/1-195             MSLIICYYGKNGAVIGGDKRQIFFRGNEEKRKILEEKLYNGEIKSEEELYKLADELNIK...IIIEDNREKVRKISDsVVVGEVRSL-GIEAKRRRVYATKGKCAIVDILNDTVTNEVIKEGFGIVVLGNRFLKKKAEEELKSSAKlfPMMPLEQIENVIRDIFEKL-NWNPTISKEYDIYSVDKYEKNFEE......VVRKDIE-s.............
A3CUY9_METMJ/1-192             MTLVIAFIGKQGAVMAGDMREIAFGGDDSSIEDLERELYGGSIASDSDLAKRADEIGVT...IQLRDDKTKVSQRDG.VLVGEVTETEGAKTSRKRLYATKGSYVIAEIVDSRLRVMQKGQASNFVVLGNDTTKEVANQCIQGMW-..EGGTIQDALRLIMLTMQIAASVTASVSRTFVLVHTDIAADVPAA......-IANDSR-k.............
G0H0U9_METMI/1-193             MSVVIGYYGKNGAVIAGDKRNLLFNGIESNRAKLEKVLYSGEIKTDEELFKKASEFDVT...VHINDTREKVKSLGN.LLSGEVVSI-GKDSKRRRMYLTKEKCAIIDIENDQITNKSVKTGSGIVVFGNRYIKHFVESEIKKHVQklLKMSAREIRDLFEKILKNI--ENATLSDNFEYYVVEAGEPEFEK......AVNKDLD-d.............
F0T5U9_METSL/1-199             MSLIVTYIGSKGCIMAGDKRRIGFYGSPEARETLEDELYAGKIKTEEDLIKKAEEQGIN...LKISDDTTKIREMDN.VLVGEVISRATHETKRKRIYAISGAYSMVELTGSNIDTVKSGGRS-IIVYGNKYTQELAEKTIKKYWK..PKMKFVDVERIMELVMSEVSENTPSVSKSFDLMIKYNSMDQKLA......--------kevirttvledvkn
A4G0H6_METM5/1-193             MSVIIGYYGKNGAVIAGDSRNLLFKGIKSNREKLEELLYSGKIRTDEELMKKASEFDVN...VYINDSEEKVRILGN.LLCGEIKSI-GKDSKRRRMYLSKEKCAVLDIENDQITNKSVKTGSGIVVFGNKYIKSLVESEIKKYIKdiLKMSVKEIKNLFEKILEKT--ENATLSGKFEYYFVETYENNFEM......AVEDDLN-e.............
A5UN99_METS3/1-199             MSLIIAYIGKKGCVMASDKRRIGYFGNKEQLNALESELYSGKIKTDEEFKKKADEYGIS...IKLTEDATKITTVGN.CVRGEVTTKKVFETYRKRIYGTTMGYQIVELSGSETVSREAGEKA-IIVFGNKFAKQEAEKLINKKWK..PSLSLKYMGDIFEEILTEISRKTPTIGNTFDVLIKQPKFNKSEAqrhlnvSIDKDIK-v.............
Q8PT14_METMA/1-193             MTLVIAFIGKNGAVMAGDMREITFEGEKPDREKLEKELYSGSIVTDEEMQKKAEEFGVK...ITVADCKEKVSERNG.VLVGEVSSAEGGVVKKRRLYASAGNFAIAELINTEMTLTSQGKGSNFIAFGNEFTKQVANKCFKDNWT..KKSNLQDAVKILILCMETVARKTASVSKQFMIVQTASNADVLKV......-VEKDRN-c.............
A6VI09_METM7/1-193             MSVVIGYYGKNGAVIAGDKRNLLFNGIESNREKLEEIMYSGQLRTDEELLKKASEFDVK...IHINDTREKVKKFGN.VLSGEVLSI-GRESKRRRMYLTKEKCVILDIENDQITNKSVKNGSGIVVFGNRYIKNLVESEIKKHVQkiLKMSAKEISALFEKILKNI--ENATLSNEFEYYFVETYENNLEK......VIENDLND..............
F6BAJ8_METIK/1-194             MSLIIGYYGRNGAVLGGDKRNIMFRGDIEKRKKLEEMLYNGEIKDDEELLKKAEEFGIK...LHIEDNRKKVRKIGDdVLVGEVKSI-GIDSERRRVYLTKGKCIIVDVFNDEIRNKWTKTGSGVVVFGNRYVKKIAEEEFRKAGYrlTMMSLEEIRDLIENIFKKC--NTPSVSKGYDIIYTTKECKNLEE......VVKKDLD-a.............
Y548_METJA/1-195               MSLIICYYGKNGAVIGGDRRQIFFRGSEENRKILEEKLYSGEIKSEEELYKLAEKLNIK...IIIEDDREKVRKISDsVVCGEVRSL-GIDAKRRRVYATKGKCAIVDILNDTVTNQTIKEGFGIVVLGNRFLKKKAEEELKRTAKlfPMMPIQQIEDAIKEIFEKL-KWHPTVSKEYDIYSVNKYEKNFEE......VIKKDIE-s.............
D7DVA7_METV3/1-192             MSVIIGYYGNNGSAIAGDKRNILFRGSEANREKLESLLYNGKLKNDKELKEKAEEYDVK...VHITDSQDKIKKLDG.CLMGEVKTI-SNQSKRKRMYLSKNNCALVEIIDDDMTKKEIKKGSGIIIFGNKHLKQLVQAELQKNVNivKSGDILKIEKLFKDILSNI--DTPSSSNDVDSYSNFKYE-NLEK......VISQE---lsn...........
F4BV53_METCG/1-189             MSLVVALTKSKEAVIGGDRRSITFLGS---WPELEEELYCGRISDDEALLAKAMEIGAI...LQVTDGRDKVWRRGD.LLVGEVTEITPQLERRRRIYLAPGSQLQVDITGKEVRIRDRGAM-GCIIYGNRFTQQIAVSIVVQAD-..----GRVDEALIRKIFQEAAERTASVSQEHVILKSERMLSNPQK......ALEKALE-edcqe.........
C9RGV7_METVM/1-195             MTLVICYYGKNGAVIGGDRRQIFFRGNEEKRKLLEEKLYSGEIKTEEELYKLAEELGVK...IIIEDDREKVRKISDtVVCGEVRSL-GVDAKRRRVYATKGKCAIIDILNDTITKEIIKEGFGLVIFGNKFLKNRAEEELRNKAKlfPMMPIQQIESEIREIFEKL-KWHPTVSKEYDIYSVNKYEKNFEE......VIKKDI--gd............
O26846_METTH/1-199             MSLIITYISSKGCVIAGDKRRIAYFGDKSSREVLEEELYTGKIKSDEELQRRASELGVN...IKVTDDTCKVRSLGD.VVVGEISQKTPFETRRRRIYATTGAYQIIELTGSRITSMEKGDTA-IIVFGNKIAKEITNRFLKKRWK..TKTSLKDVADLFRELMDHVSSQTPSVGSEYDLFIKSPSLDKKSAhrllsdTIVRDV--rl............
G6FGN3_9EURY/1-183             MSLVIAFCGRDRSFMAGDRREIVFRGDDLRTRTLEDELYSGRIRSRDALHERARELGID...LWIHDDRCKAWEEDG.ILIGQVNERDGLSTRSRRLCVSCGNYVITEVLEGIKREVTRGCASRFIVLGNKTTQEIAHRCIRSHWS.dTGGTPADALRIIILAMEEAASLTPSVSGTYTLVQTTAK------......--------tv............
A6UW86_META3/1-193             MSIIVGYYGANGAVVGGDKRNIIFRGNAEQREELEKLLYSGNIKTDEEFKKIADEYGIK...VYIEDKQLKVREVNG.VLVGEVKSI-GTDSQRRRMYLSTGNCAIIDILNDTITKKSSNVGHGLILFGNRYLKEIVHNELKKDAPnfKNMPIEKVKNIIENAIKRC--DGPTVSEEIILLHTKDKHNNFKE......LIKKDIND..............
H1KXB3_9EURY/1-194             MSVIIGYYGKNGAVLGGDKRRIMFRGDVEKRKMLEKLLYNGEIKNDEELLKKAEELGIK...LHIEDGKKKVRKIGNdVLVGEVKTI-GIDSKRRRVYLTKGKCMIVDVFNDEIKNKLIKTGSGVVVFGNKYVKKIAEDEFKKIGHrlTMMSLEEIKDIIENIFKKY--DTPSVSKEYIVVYTTKECKNLEE......VVKKDLD-e.............
D5VTH9_METIM/1-194             MSLILCYFGNNGAIILGDRREMFFRGNEEKRKELEELLYSGEIKSEEELRKKAEELGVK...IIIEDKRRKVWKIKN.VVVGEVRSL-GLDAKRRRVYATKRKAKILEILNDQIIGEKNLEGFSIIIFSNKFIKEEINKYLKEYYRvlPMKRIDEVGEIFKEIYKKV-SWHPTLSEEFDVEKTDKEEEDFEE......VIEEDVK-k.............
A6URH6_METVS/1-193             MSVIIGYYGKNGVVIAGDKRTILFNGEEKKREMLEELLYSGKIKNDDDLSEKSAEFSVK...VHILDDQKKIKQLEN.TLIGEVRTI-GKDSKRKKMYLSKDICVILDIENDNIVKKSVKTGTGIVVFGNKYVKKIVELELKKYLSeiSKMDVLKIRTIFEKILVGI--ENPTLSKGYDFLYCQNAEKDIES......IIKKDLND..............
#=GC seq_cons                  MSLlIuYhGKsGAVlAGD+RpIhFpGscppRcpLE-cLYSGcI+oDEELh++AcEhGlp...lpIsDsccKV+clus.lllGEVpol.uh-oKRRRlYsTpGshsIl-lhssplsspphtpuusllVFGN+asKclupcpl+cphp...phslpcltclhcclhccl.ppTPolSppa-lhhspsthsshct......slc+Dlp.p.............
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