GenomeNet

Database: Pfam
Entry: DUF2121
LinkDB: DUF2121
Original site: DUF2121 
#=GF ID   DUF2121
#=GF AC   PF09894.8
#=GF DE   Uncharacterized protein conserved in archaea (DUF2121)
#=GF AU   COGs, Finn RD, Sammut SJ
#=GF SE   COGs (COG4079)
#=GF GA   26.80 26.80;
#=GF TC   184.00 183.80;
#=GF NC   26.70 26.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR016754;
#=GF CC   This domain, found in various hypothetical archaeal proteins,
#=GF CC   has no known function.
#=GF SQ   34
#=GS Q8TNH4_METAC/1-191      AC Q8TNH4.1
#=GS A0A162FH67_9EURY/1-198  AC A0A162FH67.1
#=GS R9SLQ2_9EURY/1-199      AC R9SLQ2.1
#=GS A0B8J8_METTP/1-186      AC A0B8J8.1
#=GS Q8PT14_METMA/1-192      AC Q8PT14.1
#=GS A0A166BLI8_9EURY/1-198  AC A0A166BLI8.1
#=GS A0A162FIP2_9EURY/1-198  AC A0A162FIP2.1
#=GS A0A0E3NWI8_9EURY/1-192  AC A0A0E3NWI8.1
#=GS I7L117_METBM/9-199      AC I7L117.1
#=GS E3GZ98_METFV/1-198      AC E3GZ98.1
#=GS A0A0Q1A6B0_9EURY/1-191  AC A0A0Q1A6B0.1
#=GS Q8TYL1_METKA/1-201      AC Q8TYL1.1
#=GS A0A101DR40_9EURY/1-198  AC A0A101DR40.1
#=GS A6UW86_META3/1-192      AC A6UW86.1
#=GS Q6M196_METMP/1-192      AC Q6M196.1
#=GS A0A0P8CBP7_9EURY/1-190  AC A0A0P8CBP7.1
#=GS A0A126R0N8_9EURY/1-198  AC A0A126R0N8.1
#=GS A0A120K008_9EURY/1-198  AC A0A120K008.1
#=GS F0T5U9_METLA/1-198      AC F0T5U9.1
#=GS A0A101ITY5_9EURY/1-177  AC A0A101ITY5.1
#=GS A5UN99_METS3/1-198      AC A5UN99.1
#=GS U6EDG2_9EURY/8-205      AC U6EDG2.1
#=GS A0A0Q0W869_9EURY/1-187  AC A0A0Q0W869.1
#=GS A0A0Q0WJU8_9EURY/7-196  AC A0A0Q0WJU8.1
#=GS O26846_METTH/1-198      AC O26846.1
#=GS D5VTH9_METIM/1-193      AC D5VTH9.1
#=GS F6D487_METPW/1-198      AC F6D487.1
#=GS A3CUY9_METMJ/1-193      AC A3CUY9.1
#=GS F4BV53_METCG/1-188      AC F4BV53.1
#=GS G7WN05_METH6/1-187      AC G7WN05.1
#=GS Q466H3_METBF/1-192      AC Q466H3.1
#=GS D3E4F2_METRM/1-198      AC D3E4F2.1
#=GS D7DVA7_METV3/1-193      AC D7DVA7.1
#=GS Y548_METJA/1-194        AC Q57968.1
Q8TNH4_METAC/1-191                 MTLVIAFIGKNGAVMAGDMREITFEGEKPDREKLEKELYNGAIVTDEELARKAEEAGVK...ITVTDCKNKVSER..NGILVGEVSSVERGIVKKRRLYASAGSYAIAELRDSELTLTSQGKGSnFIAFGNEFTKQVANKCFKDNWT..KKSKLQDAVKVLMLCMETAAKKTASVSKQFVIVQTSS.NVD----..-VLKLVEKD--g........
A0A162FH67_9EURY/1-198             MSLIIAYIGKKGCVMASDKRKIGYFGNKENLEILENELYNAVIRDDDEFLKRAEELGIS...IKITDDANKISIV..ENTIRGEVSTKGTFETKRKRIYGTTNGYQIVELLGSEVSSRQAGKSG.IIIFGNKFAKQKAETLINRYWK..SSQSLKYMGEIFGNILEEISKKTPSIGSQFDILVKSP.NFDEMKAqkHLDVTIDHDIK.........
R9SLQ2_9EURY/1-199                 MSIIIAYIGRKGCVMASDKRRIAYFGDKDNREKLEEELYSGNIRNDEELYKEAAKLGID...LKISDDAKKIKSI..GNAVMGEVSSKTTREVRRRRIYGTTNGYQIIELIGSELKNKETGSSG.IIIFGNKIAKQMANSLIKQRWK..SSISLKYTGDIFEEIIKEIAEKTPSVGKNVDVIIGKDsKLTKTTAqkYLDETETRDI-k........
A0B8J8_METTP/1-186                 MSLVIAFSGRE-AVIAGDRRSIAFAGDCRL---LEEELYSGRIHDDVELLRRAGELSAT...IYISDGREKVWRD..GDVLVGEVTEVSASSSKRRRVYVTSGAYLIVDVVDGNARISGRGGAS.LIILGNRHTRDAAGKALQGLGK..------ISADAIARVMDEVSAGTATMSREHTLLKITA.HHKDPAS..ILMQTFSRDCE.........
Q8PT14_METMA/1-192                 MTLVIAFIGKNGAVMAGDMREITFEGEKPDREKLEKELYSGSIVTDEEMQKKAEEFGVK...ITVADCKEKVSER..NGVLVGEVSSAEGGVVKKRRLYASAGNFAIAELINTEMTLTSQGKGSnFIAFGNEFTKQVANKCFKDNWT..KKSNLQDAVKILILCMETVARKTASVSKQFMIVQTAS.NAD----..-VLKVVEKD--rn.......
A0A166BLI8_9EURY/1-198             MSLIIAYVGKKGCVIASDKRKIAYFGDKENIDKLEKELYNGNIKGDDDLYDTASKLDVS...LKISEDGIKLRSF..DKINVGEVSSKSTTETNRKRIYGTTNGYQIVELSGSKIVHTEKGNNA.LIIFGNKRTKTLANDLISKKWK..SNFSLKYMGDIFLRILEEISAKTPSIGKAYDLNIINH.KFTKEEAneYLDYFIEKDI-q........
A0A162FIP2_9EURY/1-198             MSLIIAYVGKKGCVMVADKRRISYFGDKEDIESLEDKLYSGDLENDEELKKTANLLNVS...LKISDKESKIRSL..ESSLVAEVSTKSTHKAMRKRIYATTNAYQIIELEGSNISNLDKGDSS.IIIFGNKITKSLANDFLSKEFK..ADVSLKYMGDIFTRILSKIHLKTPSIGNEFDVLVKTP.KFSKEEAqkYLDDLVKVDIK.........
A0A0E3NWI8_9EURY/1-192             MSLVIAFIGKNGAVMAGDMREITFEGEKENREKLEKDLYSGAIVSDAELEKKAEELGVK...ITVRDDKNKLEER..DGVLVGEVSSVEGGVVRKRRLYVSAGNYAIAEIEGSEIRVTAQGKGSnFIAFGNDTTKAIANKCFKDNWK..-KGNLQLAVKIIMLAMETAARKTASVSKKYMLLQTAS.NVD----..-VSGVVEKD--lse......
I7L117_METBM/9-199                 MTLVIAFIGKQGAVMAGDMREIAFFGDDSCIEELERELYNGLIASDDELKGRASEIGVT...IRVRDDKAKVSQR..DGVLIGEVTETDGSAVAKKRLYATRGSYTIAEVIDSRLRVTRRGSASnFVVLGNNITKQIANQCIQGAWE..-GGTISDAIRLIMLTMQIAASVTASVSRTFILVHTDL.AAN----..-LGSAIEQD--sr.......
E3GZ98_METFV/1-198                 MSLILAYVGKKGCVIAGDKRKIAYFGDKSSRKILEEKLYTGKIKTLDELFEEAKKLGVS...INITDNAKKVREK..GHVAIGEVGIKATHSAKRRRLYATTNCYEIIELEGSKIVKRKKGNSA.LIVFGNRITKKISNEILKKEFN..PKMSLQEIANLFKKIIKKASELTPTINKSCDIVIKNP.ILNKEMAekILEMSISEDIK.........
A0A0Q1A6B0_9EURY/1-191             MTLVMAFVGKNGAAVAGDMREILFRGDEARRRELESELYDGRIVTDADLEKRAAEIGVR...ISVRDDKSKVIRR.dDGILTGEVSKFERGTVSRRRIYAVAGQYAIADFEGGRMVIVQKKEGSaFVVLGNDITKKIANEIIRKNWK..-NGGFEDAVRVIVLAMEEAGRRTASVSRAFSIEQTDI.NVN----..-----------isaivdsea
Q8TYL1_METKA/1-201                 MTLVLAYAGTDGALVAGDRRTLVARMDEEKMRKVEEKLYSGEIRTEEELESFLKDLDVEdgyFEFHDDRKKVWKV.nDEVVAGEVGVRSAKGVRRRRVYATPGAHAIVELEGEKVLSKNFGGPA.LIVEGPKVVKELVIEFVNSELG..GKPDLESLRNALDDLFEYVSSGTILVSSEYDAYEVKG.KAD-PLAraRLQKAIDEDIE.........
A0A101DR40_9EURY/1-198             MSLIITYISSKGCVIIGDKRKIAYLGSAQNRRELERELYNGNIKTEEELRSRAEQLGIT...LNITDDAKKVRSI..GDVVVGEVSLKTPFEAKRRRIYATTGAYQIIELIGSNITKFEKGESS.IVIFGNKITKKLASKLLKKHWK..KKTSLEGISKLLKKILEDVATKTPTISREYDMYIKTP.RLDKRKAhkLLRETILRDVK.........
A6UW86_META3/1-192                 MSIIVGYYGANGAVVGGDKRNIIFRGNAEQREELEKLLYSGNIKTDEEFKKIADEYGIK...VYIEDKQLKVREV..NGVLVGEVKSIGT-DSQRRRMYLSTGNCAIIDILNDTITKKSSNVGHgLILFGNRYLKEIVHNELKKDAPnfKNMPIEKVKNIIENAIKRCD--GPTVSEEIILLHTKD.KHN----..NFKELIKKDI-n........
Q6M196_METMP/1-192                 MSVVIGYYGKNGAVIAGDKRNLLFNGIESNRAKLEEVLYSGEIKNDEELFKKASEFEVT...VHINDTREKVKSL..GNLLSGEVVSIGK-DSKRRRMYLTKEKCAIIDIENDQITNKSVKTGSgIVVFGNRYVKHFVESEIKKHVQklLKMSAREIRDLFEKILKNIE--NATLSDTFEYYVVEA.GEP----..EFEKAVNKDL-d........
A0A0P8CBP7_9EURY/1-190             MSLIIAFVGGTEAAIVADMREITFQGDKVLRERLERKLYRGAIATDIELEKMAEEIGVK...IKIRDNKIKVMQR..YGALVGEVVSVEDGFVRKRRLYATAGSYMIAETRDSEVKVTNKGGSA.FIVLGNNITKEIANKCIRENWK..-NGGFHEAIKVLILSMEAAAKVSASVSKKFIIIQTSS.NVN----..-LSEVIEQD--ki.......
A0A126R0N8_9EURY/1-198             MSLIIAYVGNKGCVMVGDKRRIAYFGSKEERELLEQEIYSGDISSDEDLYARAEELEIS...LKISDDACKVKSL..ENVAVGEVSSRGAMETKRKRIYGTTNGFQIVELTGSEIVNVKRGESS.IIVFGNKITKSLANDMLKNKWK..PSFSLKYMGEIFGQIIEDISTKTPSLGTKYDVVIQQN.NLSKTKVqdYLDEVIERDI-n........
A0A120K008_9EURY/1-198             MSLIIAYIGKKGCVMASDKRKIGYFGDKQNLKTLEEELYSGAIDNDEDFLNRASELGIS...IKITDDANKLKVV..GNTIRGEVSTKGTFETRRRRIYGTTNGYQIIELLGSETESRKAGEKG.IVIFGNVYAKQLAEPLIKRKVK..ASQSLRYMGEVFESILAEVASKTPTVGDKFDVLMQQP.VFSVSEAqkHLNITIDNDIK.........
F0T5U9_METLA/1-198                 MSLIVTYIGSKGCIMAGDKRRIGFYGSPEARETLEDELYAGKIKTEEDLIKKAEEQGIN...LKISDDTTKIREM..DNVLVGEVISRATHETKRKRIYAISGAYSMVELTGSNIDTVKSGGRS.IIVYGNKYTQELAEKTIKKYWK..PKMKFVDVERIMELVMSEVSENTPSVSKSFDLMIKYN.SMDQKLAkeVIRTTVLEDV-k........
A0A101ITY5_9EURY/1-177             --------------MAGDMREIAFEGDDPCIEELERELYSGSITSDTELAERADEIGVT...IRVRDDKAKVSQQ..GGVLIGEVTETEGPVTRRKRLYATAGSYAIAEAIDSRLRVTQRGRASnFVVLGNEVTKRIANQCIQGMWE..-GGTIQDAMRLLMLTMQITASVTASVSRTFILVHTDL.AAN----..-LVDAINQD--sr.......
A5UN99_METS3/1-198                 MSLIIAYIGKKGCVMASDKRRIGYFGNKEQLNALESELYSGKIKTDEEFKKKADEYGIS...IKLTEDATKITTV..GNCVRGEVTTKKVFETYRKRIYGTTMGYQIVELSGSETVSREAGEKA.IIVFGNKFAKQEAEKLINKKWK..PSLSLKYMGDIFEEILTEISRKTPTIGNTFDVLIKQP.KFNKSEAqrHLNVSIDKDIK.........
U6EDG2_9EURY/8-205                 MSLIITYVGSKGCVMAGDKRSIGFLGDKEQREVLEEEMYSGKIKTTEELLQRAEQLDIN...LKITDDVEKVRKI..GDVLVGEVKLRTTTETKRKRIYGTSGGYHEVELSGSQIKNAKSGQSS.IVVFGNKFTKEIANKHLQKYWK..SQTSIKEIAKIFQRIMEDVAQSTPSVSPQFDIYTVHP.QLNHKQAmeILRTTIVKDVK.........
A0A0Q0W869_9EURY/1-187             MSLVICFSGKKGAIIAGDTREILFGGDDDAVSALEEELYSGAITTEGDLQERARSLGVT...IVIRDGREKVSRR..GDILIGEVGERERDRVRKRRVYATAGSYALAEVHNSRIISAERRAGAgFVVLGNEMTKRIANQCIRDYWK..-AGTLDDAVRVIVMAMETASRVTPTVSKQYSLLQTRG.-------..-----------rgdllalle
A0A0Q0WJU8_9EURY/7-196             LSLVVGFAGKKRAILGGDRRSIVFFGGAEA---LEEELYDGKIRTDEELKKRAEELGSV...IQIANGREKVWKRndGKVLVGEVTELSASSQRRRRVYLTPGGYILVEISGKRAEVSKKGKST.LIILGNKFTRELAYRRLGSAGK..-PPEISSM----KALFEEARRATATISPDYTLLSSDE.ICSNPEA..VLLQALREDCE.........
O26846_METTH/1-198                 MSLIITYISSKGCVIAGDKRRIAYFGDKSSREVLEEELYTGKIKSDEELQRRASELGVN...IKVTDDTCKVRSL..GDVVVGEISQKTPFETRRRRIYATTGAYQIIELTGSRITSMEKGDTA.IIVFGNKIAKEITNRFLKKRWK..TKTSLKDVADLFRELMDHVSSQTPSVGSEYDLFIKSP.SLDKKSAhrLLSDTIVRDV-r........
D5VTH9_METIM/1-193                 MSLILCYFGNNGAIILGDRREMFFRGNEEKRKELEELLYSGEIKSEEELRKKAEELGVK...IIIEDKRRKVWKI..KNVVVGEVRSLGL-DAKRRRVYATKRKAKILEILNDQIIGEKNLEGFsIIIFSNKFIKEEINKYLKEYYRvlPMKRIDEVGEIFKEIYKKVS-WHPTLSEEFDVEKTDK.EEE----..DFEEVIEEDVK.........
F6D487_METPW/1-198                 MSLIITYIGSKGCVMIADKRRIGFFGEEKTREKLEEELYSGAIKTDEELLKKASSLGIT...LKITDDAEKIREI..GDIVVGEVRFKTPFETKRKRIYGTTGAYNVVELLGSEIKRIKTGESS.IVVFGNKVTKEIANKYIQNHWK..KKTNLKDIGEIFKAAMEEVAAKTPSVSQKYDLFIKHA.DIDKKEAkeLLRTTIITDVK.........
A3CUY9_METMJ/1-193                 MTLVIAFIGKQGAVMAGDMREIAFGGDDSSIEDLERELYGGSIASDSDLAKRADEIGVT...IQLRDDKTKVSQR..DGVLVGEVTETEGAKTSRKRLYATKGSYVIAEIVDSRLRVMQKGQASnFVVLGNDTTKEVANQCIQGMWE..-GGTIQDALRLIMLTMQIAASVTASVSRTFVLVHTDI.AADV---..--PAAIAN---dsrke....
F4BV53_METCG/1-188                 MSLVVALTKSKEAVIGGDRRSITFLGSWPE---LEEELYCGRISDDEALLAKAMEIGAI...LQVTDGRDKVWRR..GDLLVGEVTEITPQLERRRRIYLAPGSQLQVDITGKEVRIRDRGAMG.CIIYGNRFTQQIAVSIV-----..VQADGRVDEALIRKIFQEAAERTASVSQEHVILKSER.MLSNPQK..ALEKALEEDC-q........
G7WN05_METH6/1-187                 MSLVVGFAGKKRAIVAGDKRSIAFFGRAEE---LEEELYGGEIRSREDLQRRCEELGSK...VAIADGREKVWDR..GGVLAGEVTEISAERERRRRIYLVPGGYLLVEVDGKRAEISKRGAST.LIILGNRFTRDFAFKRLGSGRP..------PDEASIRALFEEAGRATASVSPDYTVLTSSS.IHRDPEA..ALLRALREDCE.........
Q466H3_METBF/1-192                 MTLVIAFIGKNGAVMTGDLREITFEGEKPNREKLEKELYNGTIVTDDELAKKARAFGVG...ITVTDCKSKISER..EGILIGEVSSIEGGVTKKRRLYASAGNYAIAELKDSKITLISHAKGSnLIILGNDFTKQVANKCFKDNWT..KKSTFQDAIKILMLCMETAARKTASVSKQFFLIQTTS.NVD----..-VLKIVEKD--rn.......
D3E4F2_METRM/1-198                 MSLIIAYVGKKGCVMAADKRRIAYFGLKEQREILEQEIYSGEIHNDEELYARAEELDVN...LKVTDNACKVKSI..ENVAIGEVSSRGTMETKRKRIYGTSNGFKIIELSGSHVLNSKRGVSS.IIVFGNKVTKSLANKMIQERWK..PSFSLKYMGEIFGEILKDIAEITPSVGKDYDVIIEKN.NLAKSQVqdYIDEVAERDV-k........
D7DVA7_METV3/1-193                 MSVIIGYYGNNGSAIAGDKRNILFRGSEANREKLESLLYNGKLKNDKELKEKAEEYDVK...VHITDSQDKIKKL..DGCLMGEVKTISN-QSKRKRMYLSKNNCALVEIIDDDMTKKEIKKGSgIIIFGNKHLKQLVQAELQKNVNivKSGDILKIEKLFKDILSNID--TPSSSNDVDSYSNFK.YEN----..-LEKVISQE--lsnl.....
Y548_METJA/1-194                   MSLIICYYGKNGAVIGGDRRQIFFRGSEENRKILEEKLYSGEIKSEEELYKLAEKLNIK...IIIEDDREKVRKI.sDSVVCGEVRSLGI-DAKRRRVYATKGKCAIVDILNDTVTNQTIKEGFgIVVLGNRFLKKKAEEELKRTAKlfPMMPIQQIEDAIKEIFEKLK-WHPTVSKEYDIYSVNK.YEK----..NFEEVIKKDIE.........
#=GC seq_cons                      MSLlIualG+pGsVhAGD+RcIsFhGccpshcpLEcELYuGpIcoDEELh++AcElGls...lpIsDcppKVpph..sslllGEVophsshps+RRRlYuTsGuYtIlElhsSclpspppGpuu.lIlaGN+hTKplAschlpcpW+...phslpphtclhttlhccsuptTsSVScpasllhsps.phs.......LppslpcDh..........
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